TPMT

Summary

Gene Symbol: TPMT
Description: thiopurine S-methyltransferase
Alias: TPMTD, thiopurine S-methyltransferase, S-adenosyl-L-methionine:thiopurine S-methyltransferase
Species: human

Top Publications

  1. pmc Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population
    Samar I Hamdy
    Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan, and Faculty of Pharmacy, Cairo University, Egypt
    Br J Clin Pharmacol 55:560-9. 2003
  2. ncbi Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms
    E Y Krynetski
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pharmacogenetics 6:279-90. 1996
  3. ncbi Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance
    C R Yates
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Ann Intern Med 126:608-14. 1997
  4. pmc Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity
    H L Tai
    St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38101, USA
    Proc Natl Acad Sci U S A 94:6444-9. 1997
  5. ncbi Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms
    D Otterness
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, MN 55905, USA
    Clin Pharmacol Ther 62:60-73. 1997
  6. ncbi Thiopurine methyltransferase alleles in British and Ghanaian populations
    M M Ameyaw
    University of Aberdeen, Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Hum Mol Genet 8:367-70. 1999
  7. ncbi The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations
    E S Collie-Duguid
    The University of Aberdeen, Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, UK
    Pharmacogenetics 9:37-42. 1999
  8. ncbi Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population
    M Hiratsuka
    Department of Pharmaceutical Sciences, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai, Japan
    Mutat Res 448:91-5. 2000
  9. ncbi Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations
    Jan Gowth Chang
    Department of Laboratory Medicine, China Medical College Hospital, Taichung, Taiwan
    Pharmacogenetics 12:191-5. 2002
  10. ncbi Thiopurine methyltransferase polymorphisms in a multiracial asian population and children with acute lymphoblastic leukemia
    S K Y Kham
    Department of Pediatrics, National University of Singapore, Singapore
    J Pediatr Hematol Oncol 24:353-9. 2002

Research Grants

Detail Information

Publications202 found, 100 shown here

  1. pmc Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population
    Samar I Hamdy
    Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan, and Faculty of Pharmacy, Cairo University, Egypt
    Br J Clin Pharmacol 55:560-9. 2003
    The goal of this study was to determine the frequencies of important allelic variants in the TPMT, NAT2, GST, SULT1A1 and MDR-1 genes in the Egyptian population and compare them with the frequencies in other ethnic populations.
  2. ncbi Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms
    E Y Krynetski
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pharmacogenetics 6:279-90. 1996
    Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurines such as mercaptopurine and thioguanine...
  3. ncbi Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance
    C R Yates
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Ann Intern Med 126:608-14. 1997
    Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (that is, inactivation) of mercaptopurine, azathioprine, and thioguanine and exhibits genetic polymorphism...
  4. pmc Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity
    H L Tai
    St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38101, USA
    Proc Natl Acad Sci U S A 94:6444-9. 1997
    b>TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including medications such as mercaptopurine and thioguanine...
  5. ncbi Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms
    D Otterness
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, MN 55905, USA
    Clin Pharmacol Ther 62:60-73. 1997
    Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT activity is regulated by a common genetic polymorphism that is associated with large individual variations in thiopurine toxicity and efficacy...
  6. ncbi Thiopurine methyltransferase alleles in British and Ghanaian populations
    M M Ameyaw
    University of Aberdeen, Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Hum Mol Genet 8:367-70. 1999
    Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercapto-purine, 6-thioguanine and azathioprine...
  7. ncbi The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations
    E S Collie-Duguid
    The University of Aberdeen, Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, UK
    Pharmacogenetics 9:37-42. 1999
    ..The wild-type allele is defined as TPMT*1 and the mutant alleles are TPMT*2 (G238C), TPMT*3A (G460A and A719G), TPMT*3B (G460A) and TPMT*3B (A719G)...
  8. ncbi Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population
    M Hiratsuka
    Department of Pharmaceutical Sciences, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai, Japan
    Mutat Res 448:91-5. 2000
    Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathiopurine...
  9. ncbi Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations
    Jan Gowth Chang
    Department of Laboratory Medicine, China Medical College Hospital, Taichung, Taiwan
    Pharmacogenetics 12:191-5. 2002
    Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. In Caucasians, four variant TPMT alleles have been detected in over 80% of individuals with low or intermediate TPMT activity...
  10. ncbi Thiopurine methyltransferase polymorphisms in a multiracial asian population and children with acute lymphoblastic leukemia
    S K Y Kham
    Department of Pediatrics, National University of Singapore, Singapore
    J Pediatr Hematol Oncol 24:353-9. 2002
    The purpose of this study was to determine the frequency of thiopurine methyltransferase (TPMT) polymorphisms in a multiracial Asian population and to assess its relevance in the management of childhood acute lymphoblastic leukemia (ALL)...
  11. ncbi Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism
    Matthias Schwab
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Pharmacogenetics 12:429-36. 2002
    ..Whereas azathioprine-related pancytopenia has been clearly linked to thiopurine S-methyltransferase (TPMT) polymorphism limited data are available to explain gastrointestinal side effects...
  12. ncbi Thiopurine methyltransferase polymorphisms in a Brazilian population
    W L Boson
    Departamento de Farmacologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Pharmacogenomics J 3:178-82. 2003
    Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Low-activity phenotypes are correlated with several mutations in the TPMT gene...
  13. ncbi Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants
    Elke Schaeffeler
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Pharmacogenetics 14:407-17. 2004
    The thiopurine S-methyltransferase (TPMT) genetic polymorphism has a significant clinical impact on the toxicity of thiopurine drugs...
  14. ncbi Molecular analysis of the thiopurine S-methyltransferase alleles in Bolivians and Tibetans
    H F Lu
    Department of Molecular Medicine, China Medical University Hospital, Taichung, China
    J Clin Pharm Ther 30:491-6. 2005
    Thiopurine drugs are used as immunosuppressant or cytotoxic drugs. Thiopurine S-methyltransferase (TPMT) methylates and thereby modulates the therapeutic and toxic effects of these drugs...
  15. ncbi Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy
    Thierry Dervieux
    Prometheus Laboratories, San Diego, CA 92121, USA
    Clin Chem 51:2074-84. 2005
    Polymorphic thiopurine S-methyltransferase (TPMT) is a major determinant of thiopurine toxicity.
  16. ncbi TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease
    G Stocco
    Department of Biomedical Sciences, University of Trieste, via L Giorgieri 7, 9, Italy
    Dig Liver Dis 37:940-5. 2005
    ..They are metabolised via methylation by thiopurine-S-methyltransferase (TPMT), which displays a genetically determined polymorphic activity...
  17. ncbi Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression
    Zuzana Zelinkova
    Laboratory of Experimental Internal Medicine, Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Gastroenterol Hepatol 4:44-9. 2006
    ..Mutations in the thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genes have been associated with the occurrence of AZA-related ..
  18. ncbi Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease
    Gabriele Stocco
    Department of Biomedical Sciences, University of Trieste, Trieste, Italy
    Inflamm Bowel Dis 13:57-64. 2007
    ..occur in 15%-38% of patients and the majority are not explained by thiopurine-S-methyltransferase (TPMT) deficiency...
  19. doi Thiopurine S-methyltransferase activity in three major Asian populations: a population-based study in Singapore
    Shirley Kow Yin Kham
    Department of Paediatrics, National University of Singapore, and Department of Haematology Oncology, National University Hospital, Singapore City, Republic of Singapore
    Eur J Clin Pharmacol 64:373-9. 2008
    The distribution of thiopurine methyltransferase (TPMT) activity in Asian populations has not been well documented...
  20. doi Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease
    A Ansari
    Department of Gastroenterology, St Thomas Hospitals Foundation, NHS Trust, London, UK
    Aliment Pharmacol Ther 28:973-83. 2008
    ..To investigate whether pharmacogenetic loci or metabolite concentrations explain clinical response or side effects to AZA...
  21. doi Duplex pyrosequencing of the TPMT*3C and TPMT*6 alleles in Korean and Vietnamese populations
    Sang Seop Lee
    Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, 633 165 Gaegum Dong, Jin gu, Busan 614 735, Republic of Korea
    Clin Chim Acta 398:82-5. 2008
    Thiopurine S-methyltransferase (TPMT) genetic polymorphisms have been studied intensively in relation to thiopurine toxicity...
  22. doi Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data
    Marcilene Rezende Silva
    Department of Paediatrics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Ther Drug Monit 30:700-4. 2008
    The frequency of allele variants of gene TPMT*2, *3A, *3B, and *3C was estimated in a population of 116 Brazilian children with acute lymphoblastic leukemia...
  23. doi Thiopurine S-methyltransferase genotype-phenotype concordance: used as a quality assurance tool to help control the phenotype assay
    Loretta Ford
    Department of Clinical Biochemistry, City Hospital, Birmingham, UK
    Ann Clin Biochem 46:152-4. 2009
    As part of the quality control system for our TPMT phenotyping service we monitor the genotype-phenotype concordance for patient samples with deficient and low TPMT activity...
  24. doi Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment
    Kan Uchiyama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine Kashiwa Hospital, 163 1 Kashiwa shita, Kashiwa, Chiba, 277 8567, Japan
    J Gastroenterol 44:197-203. 2009
    ..adverse reactions is a reduction in the activities of the metabolizing enzymes thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase (ITPA)...
  25. doi [Thiopurine S-methyltransferase gene polymorphism in Chilean blood donors]
    Luis Alvarez L
    Sección de Gastroenterología, Departamento de Medicina Interna, Hospital Clinico Universidad de Chile
    Rev Med Chil 137:185-92. 2009
    Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the S-methylation of 6-mercaptopurine and azathioprine. Low-activity phenotypes are correlated with polymorphism in the TPMT gene...
  26. doi Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease
    Noritaka Takatsu
    Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan
    J Gastroenterol Hepatol 24:1258-64. 2009
    ..We examined polymorphism of the thiopurine S-methyltransferase (TPMT) gene to determine whether the TPMT genotype would be a predictive marker for the development of adverse reactions ..
  27. doi Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia
    Gauri Kapoor
    Department of Pediatric Hematology and Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi 110085, India gauri
    Leuk Res 34:1023-6. 2010
    The prevalence of thiopurine S-methyltransferase (TPMT) polymorphism and its association with clinical and hematological toxicities was retrospectively analyzed in 71 Indian children with acute lymphoblastic leukemia (ALL)...
  28. doi Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study
    Jae Hak Kim
    Department of Internal Medicine, Dongguk University College of Medicine, Goyang si, Korea
    J Clin Gastroenterol 44:e242-8. 2010
    ..The purpose of this study was to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in ..
  29. pmc Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease
    Xian Wen Dong
    Department of Gastroenterology, Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, School of Medicine, Shanghai 200001, China
    World J Gastroenterol 16:3187-95. 2010
    To evaluate the relationship between thiopurine S-methyltransferase (TPMT) polymorphisms and thiopurine-induced adverse drug reactions (ADRs) in inflammatory bowel disease (IBD).
  30. pmc Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia
    Lynne Lennard
    Clinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, UK
    Br J Clin Pharmacol 76:125-36. 2013
    ..marrow activity can influence red blood cell (RBC) kinetics, the surrogate tissue for thiopurine methyltransferase (TPMT) measurements...
  31. pmc Thiopurine-methyltransferase variants in inflammatory bowel disease: prevalence and toxicity in Brazilian patients
    Ana Teresa P Carvalho
    Ana Teresa P Carvalho, Barbara C Esberard, Renata S B Fróes, Ana B Grinman, Disciplina de Gastroenterologia e Endoscopia Digestiva, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ 20551 900, Brazil
    World J Gastroenterol 20:3327-34. 2014
    To analyze the prevalence of thiopurine-methyltransferase (TPMT) genotypes and their association with drug toxicity in inflammatory bowel disease (IBD) patients from southeastern Brazil.
  32. pmc Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
    H L Tai
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Am J Hum Genet 58:694-702. 1996
    The autosomal recessive trait of thiopurine S-methytransferase (TPMT) deficiency is associated with severe hematopoietic toxicity when patients are treated with standard doses of mercaptopurine, azathioprine, or thioguanine...
  33. pmc Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus
    T Kubota
    Research Testing Department, SRL, Inc, Hachioji shi, Tokyo, Japan
    Br J Clin Pharmacol 51:475-7. 2001
    To determine the frequencies of four thiopurine S-methyltransferase (TPMT) mutant alleles, TPMT*2, *3A, *3B and *3C in a normal Japanese population.
  34. ncbi Thiopurine S-methyltransferase polymorphisms and the relationship between the mutant alleles and the adverse effects in systemic lupus erythematosus patients taking azathioprine
    J B Jun
    The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea
    Clin Exp Rheumatol 23:873-6. 2005
    The present study sought to elucidate the genetic basis of thiopurine methyltransferase (TPMT) polymorphism and subsequently to investigate the relationship between mutant TPMT and an adverse response observed in Korean patients with ..
  35. ncbi Pharmacokinetics of 6-thioguanine in patients with inflammatory bowel disease
    Luc J J Derijks
    Department of Clinical Pharmacy, Maxima Medical Center, Veldhoven, The Netherlands
    Ther Drug Monit 28:45-50. 2006
    ..measures included mean 6-TGN concentrations (+/-95% confidence interval [CI95%]) and their associations with TPMT genotype, 6-TG dose, and hematological, hepatic, pancreatic, and efficacy parameters during the 8 week period...
  36. doi Thiopurine methyltransferase gene polymorphisms in Chinese patients with inflammatory bowel disease
    Qian Cao
    Department of Gastroenterology, Sir Run Run Shaw Institute of Clinical Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Digestion 79:58-63. 2009
    ..variability exists in the efficacy and toxicity of the drugs, and this results from thiopurine methyltransferase (TPMT) gene polymorphisms...
  37. doi Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications?
    Jenny E Higgs
    Central Manchester and Manchester Children s University Hospitals NHS Trust, Manchester Royal Infirmary, Manchester, UK
    Pharmacogenomics 11:177-88. 2010
    Thiopurine S-methyltransferase (TPMT) metabolizes thiopurine medications, including azathioprine and 6-mercaptopurine. Absent TPMT activity (i.e...
  38. doi The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease
    Hiromistu Ban
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Gastroenterol 45:1014-21. 2010
    ..In this study, we investigated the association between MRP4 G2269A polymorphism and thiopurine sensitivity in Japanese IBD patients...
  39. ncbi Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
    Anthony M Marinaki
    Purine Research Laboratory, Department of Chemical Pathology and Department of Gastroenterology, Guy s and St Thomas Hospital, London, UK
    Pharmacogenetics 14:181-7. 2004
    ..6-MP), occur in 15% to 28% of patients and the majority are not explained by thiopurine methyltransferase (TPMT) deficiency...
  40. ncbi 5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine
    Scott Hande
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Inflamm Bowel Dis 12:251-7. 2006
    ..azathioprine (AZA) or 6-mercaptopurine (6-MP), presumably through the inhibition of thiopurine methyltransferase (TPMT)...
  41. ncbi Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing
    Alexander Teml
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Clin Pharmacokinet 46:187-208. 2007
    ..The catabolic enzyme thiopurine S-methyltransferase (TPMT) is polymorphically expressed, and currently 23 genetic variants have been described...
  42. doi Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease
    L Y Kwan
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Dig Liver Dis 40:425-32. 2008
    ..Our aim was to determine if thiopurine methyltransferase enzyme activity and 6-thioguanine nucleotide level monitoring would predict response to therapy with thiopurines in patients with inflammatory bowel disease...
  43. doi State-of-the-art: Immunosuppression and biologic therapy
    William J Sandborn
    Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Dig Dis 28:536-42. 2010
    ..Clinical practice should change such that combination therapy with an anti-TNF agent and azathioprine replace azathioprine in patients failing first line therapy with mesalamine and/or steroids...
  44. ncbi Analytic aspects of monitoring therapy with thiopurine medications
    Victor W Armstrong
    Department of Clinical Chemistry, George August University, D 37075 Goettingen, Germany
    Ther Drug Monit 26:220-6. 2004
    ..One person in 300 in white populations has low or undetectable TPMT activity and is at risk for accumulating 6-TGN with the consequence of severe, life-threatening myelosuppression...
  45. ncbi [Thiopurine methyltransferase activity and myelosuppression in inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine]
    Javier P Gisbert
    Servicio de Aparato Digestivo Hospital Universitario de la Princesa Universidad Autónoma Madrid Spain
    Med Clin (Barc) 121:1-5. 2003
    We aimed at assessing whether there exists a relationship between thiopurine methyltransferase (TPMT) activity and the incidence of adverse events, especially myelotoxicity, in patients with inflammatory bowel disease treated with ..
  46. ncbi Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
    W E Evans
    St Jude Children s Research Hospital and University of Tennessee, Memphis 38101 0318, USA
    J Clin Oncol 19:2293-301. 2001
    To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), and to evaluate their clinical management.
  47. ncbi Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
    J F Colombel
    Service d Hepato Gastroenterologie, Hopital Huriez, CHRU Lille, France
    Gastroenterology 118:1025-30. 2000
    ..disease (CD) treated with azathioprine has been attributed to low activity of thiopurine S-methyltransferase (TPMT). Allelic variants of the TPMT gene responsible for changes in the enzyme activity have been characterized...
  48. doi Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status
    Gabriele Stocco
    St Jude Children s Research Hospital, Department of Pharmaceutical Sciences, 262 Danny Thomas Place MS 272, Memphis, TN 38105, USA
    Expert Opin Drug Saf 9:23-37. 2010
    Although genetic polymorphisms in the gene encoding human thiopurine methyltransferase (TPMT) are known to have a marked effect on mercaptopurine metabolism and toxicity, there are many patients with wild-type TPMT who develop toxicity...
  49. ncbi 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial
    Max Reinshagen
    Department of Medicine I, Klinikum Braunschweig, Braunschweig, Germany
    Clin Chem 53:1306-14. 2007
    ..A prospective randomized trial in patients with Crohn disease studied whether 6-thioguanine nucleotide (6-TGN) concentration-adapted azathioprine (AZA) therapy is clinically superior to a standard dose of 2.5 mg/kg/day AZA...
  50. doi Thiopurine S- methyltransferase [corrected] testing in idiopathic pulmonary fibrosis: a pharmacogenetic cost-effectiveness analysis
    Jared T Hagaman
    Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, 231 Albert Sabin Way ML 0564, Cincinnati, OH 45267, USA
    Lung 188:125-32. 2010
    ..A genotypic assay, thiopurine S-methyltransferase (TPMT), has been developed that can potentially identify those at risk for developing leukopenia with azathioprine, and ..
  51. ncbi Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial
    Simon J Meggitt
    School of Clinical and Laboratory Sciences Dermatological Sciences, University of Newcastle upon Tyne, UK
    Lancet 367:839-46. 2006
    ..for moderate-to-severe atopic eczema, and the therapeutic importance of the thiopurine methyltransferase (TPMT) polymorphism (a key determinant of azathioprine-induced myelotoxicity) by using TPMT enzyme activity to establish ..
  52. ncbi Impact of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations in patients with chronic inflammatory diseases
    Jörg Schedel
    Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Hospital of Regensburg, D 93042 Regensburg, Germany
    Ann N Y Acad Sci 1069:477-91. 2006
    ..chronic inflammatory diseases, the effect of the azathioprine metabolizing enzyme thiopurine methyltransferase (TPMT) activity on incidence of adverse events (AE) was examined...
  53. ncbi Pharmacological monitoring of azathioprine therapy
    L O Reuther
    Dept of Clinical Pharmacology, Gentofte University Hospital, Hellerup, Denmark
    Scand J Gastroenterol 38:972-7. 2003
    ..Thiopurine methyltransferase (TPMT) is responsible for the formation of methylated metabolites and lower E-TGN levels, and TPMT genotyping has been ..
  54. doi A 6-thioguanine nucleotide threshold level of 400 pmol/8 x 10(8) erythrocytes predicts azathioprine refractoriness in patients with inflammatory bowel disease and normal TPMT activity
    Xavier Roblin
    Department of Gastroenterology, CHU Grenoble, Grenoble, France
    Am J Gastroenterol 103:3115-22. 2008
    ..We investigated the threshold value of 6-TGN that may be predictive of AZA refractoriness and its impact on safety profile...
  55. ncbi Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine
    Karin Dilger
    Dr Falk Pharma GmbH, Freiburg, Germany
    Ther Drug Monit 29:1-5. 2007
    Thiopurine methyltransferase (TPMT) activity determines biotransformation of azathioprine and, thereby, drug efficacy and safety...
  56. pmc Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease
    U Hindorf
    Department of Clinical Sciences, Division of Gastroenterology, Faculty of Medicine, Lund University, 22185 Lund, Sweden
    Gut 55:1423-31. 2006
    Firm recommendations about the way thiopurine drugs are introduced and the use of thiopurine methyltransferase (TPMT) and metabolite measurements during treatment in inflammatory bowel disease (IBD) are lacking.
  57. ncbi Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription
    E A Fargher
    North West Genetics Knowledge Park Nowgen, Manchester, UK
    J Clin Pharm Ther 32:187-95. 2007
    ..Thiopurine methyltransferase (TPMT) is a genetically moderated key enzyme involved in the metabolism of AZA that can be used to stratify individuals ..
  58. ncbi High 6-thioguanine nucleotide levels and low thiopurine methyltransferase activity in patients with lupus erythematosus treated with azathioprine
    G Decaux
    General Internal Medicine Department, University Hospital Erasme, Brussels, Belgium
    Am J Ther 8:147-50. 2001
    ..The 6-TGN levels are known to be affected by the activity of the key enzyme, thiopurine methyltransferase (TPMT), which is under genetic dependence...
  59. ncbi [Thiopurine methyltransferase activity in patients with autoimmune hepatitis]
    Javier P Gisbert
    Servicio de Gastroenterología y Hepatología Hospital Universitario de la Princesa Universidad Autónoma Madrid Spain
    Med Clin (Barc) 121:481-4. 2003
    The measurement of the activity of thiopurine methyltransferase (TPMT) is useful to monitor, on an individual basis, the dose of azathioprine in order to identify patients at risk of myelotoxicity...
  60. pmc TPMT*26 (208F-->L), a novel mutation detected in a Chinese
    Shirley Kow Yin Kham
    Department of Paediatrics, Division of Haematology and Oncology, Yong Loo Lin School of Medicine, National University Health System, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    Br J Clin Pharmacol 68:120-3. 2009
    ..These manifestations may be attributed to polymorphisms or mutations in the thiopurine methyltransferase (TPMT) gene that might result in low TPMT enzyme activity...
  61. pmc IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations
    Sofie Haglund
    Research and Development in Laboratory Medicine, Laboratory Medicine, Ryhov Hospital, Linkoping, Sweden
    Br J Clin Pharmacol 65:69-77. 2008
    ..The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is of importance for thiopurine metabolism and occurrence of adverse events...
  62. ncbi Long-term results of TPMT activity monitoring in azathioprine-treated renal allograft recipients
    E Thervet
    Service de Nephrologie, Hopital Saint Louis, Paris, France
    J Am Soc Nephrol 12:170-6. 2001
    Thiopurine methyltransferase (TPMT) is implicated in the metabolism of azathioprine. The consequences of differential TPMT activity induction by azathioprine on the long-term results after renal transplantation were investigated...
  63. ncbi Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease
    L P L Gilissen
    Department of Gastroenterology and Hepatology, University Hospital Maastricht azM, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Dig Liver Dis 39:182-6. 2007
    ..Genotyping showed a wildtype thiopurine S-methyltransferase TPMT(H/H) (*1/*1) genotype and a wildtype inosine triphosphate pyrophosphatase gene...
  64. doi An audit of thiopurine methyltransferase genotyping and phenotyping before intended azathioprine treatment for dermatological conditions
    T Vestergaard
    Department of Dermatology, Odense University Hospital, Odense, Denmark
    Clin Exp Dermatol 35:140-4. 2010
    Determining thiopurine methyltransferase (TPMT) genotype and phenotype before azathioprine treatment predicts which patients are most likely to develop myelosuppression.
  65. doi Should azathioprine and 5-aminosalicylates be coprescribed in inflammatory bowel disease?: an audit of adverse events and outcome
    Jayshri A Shah
    Bristol Royal Infirmary, Bristol, UK
    Eur J Gastroenterol Hepatol 20:169-73. 2008
    ..An interaction between azathioprine and 5-aminosalicylates may exist, but the mechanism remains unclear...
  66. ncbi Erythrocyte thiopurine methyl transferase assessment prior to azathioprine use in the UK
    S A Holme
    Department of Dermatology, Royal Gwent Hospital, Newport, Purine Research Laboratory and Department of Gastroenterology, Guy s and St Thomas Hospitals Trust, London, UK
    QJM 95:439-44. 2002
    Individuals with low activity of a key metabolic enzyme, thiopurine methyl transferase (TPMT), are more susceptible to azathioprine-induced myelosuppression.
  67. pmc TPMT in the treatment of Crohn's disease with azathioprine
    L Lennard
    Academic Unit of Molecular and Clinical Pharmacology, School of Medicine, University of Sheffield, UK
    Gut 51:143-6. 2002
    Azathioprine induced profound myelosuppression linked to TPMT deficiency has now been documented in many patient groups, including those with Crohn's disease...
  68. ncbi Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency
    Lesley Ann Murphy
    St Johns Institute of Dermatology, London, United Kingdom
    Pediatr Dermatol 20:531-4. 2003
    Azathioprine is a valuable agent in the treatment of severe childhood atopic eczema. Thiopurine methyl transferase (TPMT) exhibits autosomal codominant polymorphism and plays an important role in the metabolism of azathioprine...
  69. ncbi Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease
    J Winter
    Gastroenterology Unit, Gartnavel General Hospital, Glasgow, Scotland
    Aliment Pharmacol Ther 20:593-9. 2004
    ..Its use is limited by its side-effect profile. Marrow toxicity occurs in approximately 3.2% of patients and is known to be associated with diminished thiopurine methyltransferase enzyme activity resulting from genetic polymorphisms...
  70. ncbi Azathioprine for atopic dermatitis
    S J Meggitt
    Department of Dermatology, University of Newcastle, Newcastle upon Tyne, UK
    Clin Exp Dermatol 26:369-75. 2001
    ..now known to be related to the activity of a key enzyme in azathioprine metabolism, thiopurinemethyltransferase (TPMT)...
  71. doi S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts
    Miha Milek
    University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
    Biochem Pharmacol 77:1845-53. 2009
    ..Side-effects of thiopurine therapy have been correlated with thiopurine methyltransferase (TPMT) activity...
  72. ncbi Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
    M V Relling
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Natl Cancer Inst 91:2001-8. 1999
    ..are often treated with 6-mercaptopurine, and those with homozygous deficiency in thiopurine S-methyltransferase (TPMT) enzyme activity have an extreme sensitivity to this drug as a result of the accumulation of higher cellular ..
  73. ncbi Increased concentrations of methylated 6-mercaptopurine metabolites and 6-thioguanine nucleotides in human leukemic cells in vitro by methotrexate
    T Giverhaug
    Department of Pharmacology, Institute of Medical Biology, University of Tromsø, Norway
    Biochem Pharmacol 55:1641-6. 1998
    ..CCRF-CEM, WI-L2, TBJ, and HL-60 all expressed thiopurine methyltransferase (TPMT) activity...
  74. ncbi The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase
    A G Hall
    Leukaemia Research Fund Laboratory, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Biochem Biophys Methods 47:65-71. 2001
    The level of expression of the enzyme thiopurine methyltransferase (TPMT) is an important determinant of the metabolism of drugs used both in the treatment of acute leukaemia (6-mercaptopurine and 6-thioguanine) and as an ..
  75. ncbi Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia
    Kjeld Schmiegelow
    Department of Pediatrics, The University Hospital and The University of Copenhagen, Denmark
    J Clin Oncol 21:1332-9. 2003
    ..Methylated MP metabolites (formed by thiopurine methyltransferase [TPMT]) and methotrexate (MTX) polyglutamates can inhibit de novo purine synthesis...
  76. ncbi The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients
    L P L Gilissen
    Department of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands
    Aliment Pharmacol Ther 22:605-11. 2005
    ..studies suggest interactions between mesalazine (mesalamine) and thiopurines by thiopurine S-methyltransferase (TPMT) inhibition, influencing the balance of hepatotoxic 6-methylmercaptopurine ribonucleotide and immunosuppressive ..
  77. doi The effect of thiopurine drugs on DNA methylation in relation to TPMT expression
    L A Hogarth
    Leukaemia Research Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Biochem Pharmacol 76:1024-35. 2008
    ..Thiopurine methyltransferase (TPMT) metabolises thiopurine drugs and influences their cytotoxic activity...
  78. ncbi 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease
    Marla C Dubinsky
    Division of Gastroenterology and Genetics, Department of Medicine and Pediatrics, Cedars Sinai Medical Center, UCLA, Los Angeles, California 90048, USA
    Gastroenterology 122:904-15. 2002
    ..An inverse correlation between 6-TGN and thiopurine methyltransferase (TPMT) has been described...
  79. ncbi Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice
    R B Gearry
    Department of Medicine, Christchurch School of Medicine and Health Sciences, New Zealand
    Intern Med J 35:580-5. 2005
    ..Assessing thiopurine methyltransferase (TPMT) status has been recommended to reduce the risk of serious toxicity...
  80. ncbi The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia
    Lynne Lennard
    Academic Unit of Clinical Pharmacology, University of Sheffield, Sheffield, United Kingdom
    Clin Pharmacol Ther 80:375-83. 2006
    ..This trial compared the efficacy and toxicity of thioguanine (INN, thioguanine) versus mercaptopurine...
  81. ncbi Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics
    Christine Hartford
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, University of Tennessee, Memphis, Tennessee, USA
    Cancer Res 67:4965-72. 2007
    The recessive deficiency in thiopurine methyltransferase (TPMT), caused by germ-line polymorphisms in TPMT, can cause severe toxicity after mercaptopurine...
  82. ncbi Determination of thiopurine methyltransferase phenotype in isolated human erythrocytes using a new simple nonradioactive HPLC method
    Dessislava Indjova
    Department of Clinical Laboratory, Medical University Sofia, Sofia, Bulgaria
    Ther Drug Monit 25:637-44. 2003
    Genetic polymorphism of the S-methylation pathway catalyzed by thiopurine methyltransferase (TPMT) is responsible for variation in the metabolism, toxicity, and therapeutic efficacy of thiopurine drugs...
  83. ncbi Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity
    Ulrikka Nygaard
    The Pediatric Clinic II, The University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Clin Pharmacol Ther 75:274-81. 2004
    ....
  84. ncbi [Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease]
    Javier P Gisbert
    Servicio de Aparato Digestivo Hospital Universitario de La Princesa Universidad Autónoma Madrid España
    Gastroenterol Hepatol 29:568-83. 2006
    Determination of the activity of thiopurine methyltransferase (TPMT) and of thiopurine metabolites (6-thioguanine and 6-methylmercaptopurine nucleotides) could be useful for individualized monitoring of azathioprine (AZA) and 6-..
  85. ncbi Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel disease
    Ahmed Morales
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Inflamm Bowel Dis 13:380-5. 2007
    ..However, many physicians prescribe AZA/6MP using milligrams per kilogram (mg/kg) dosing regimens without measuring 6-TGN levels. The aim of this study was to examine the association between 6MP dose and 6-TGN levels...
  86. ncbi Methotrexate increases red blood cell concentrations of 6-methylmercaptopurine ribonucleotide in rats in vivo
    T Giverhaug
    Department of Pharmacology, University of Tromsø, Norway
    Cancer Chemother Pharmacol 40:367-70. 1997
    ..To elucidate the effect of methotrexate (MTX) on 6-mercaptopurine (6-MP) metabolism in rats...
  87. ncbi Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia
    H L McLeod
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen
    Br J Haematol 105:696-700. 1999
    ..efficacy of 6MP is significantly influenced by inactivation by the polymorphic enzyme thiopurine methyltransferase (TPMT). In the general population 89-94% have high TPMT activity, 6-11% have intermediate activity, and approximately 0...
  88. ncbi Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1
    D Lee
    Department of Pharmacology, Mayo Medical School, Rochester, MN 55905 0001, USA
    Drug Metab Dispos 23:398-405. 1995
    Thiopurine methyltransferase (TPMT) is a genetically polymorphic enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine...
  89. pmc A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
    E Y Krynetski
    Pharmaceutical Department, St Jude Children s Research Hospital, Memphis, TN 38105
    Proc Natl Acad Sci U S A 92:949-53. 1995
    Thiopurine S-methyltransferase (TPMT; S-adenosyl-L-methionine:thiopurine S-methyltransferase, EC 2.1.1.67) activity exhibits genetic polymorphism, with approximately 0...
  90. pmc Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?
    L Lennard
    University of Sheffield Department of Medicine, Royal Hallamshire Hospital, UK
    Br J Cancer 68:186-90. 1993
    The cytotoxic activity of 6-mercaptopurine (6-MP) is affected by thiopurine methyltransferase (TPMT), a genetically regulated and variable intracellular enzyme...
  91. ncbi Human thiopurine methyltransferase: no evidence of activation by its substrates
    I Stupans
    Centre for Pharmaceutical Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide
    Life Sci 62:343-50. 1998
    ..The effects of 6-thioguanine on 6-mercaptopurine metabolism were determined. 6-Thioguanine was found to be a mixed inhibitor of 6-mercaptopurine methylation...
  92. ncbi Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia
    Thomas C Wood
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    Drug Metab Dispos 30:1123-8. 2002
    ..S-methylation catalyzed by the genetically polymorphic drug-metabolizing enzyme thiopurine S-methyltransferase (TPMT). Initially, we tested recombinant human TPMT as a "reagent" to S-methylate MTD...
  93. ncbi Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease
    R B Gearry
    Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand
    Aliment Pharmacol Ther 18:395-400. 2003
    ..The likelihood and type of adverse effect may relate to thiopurine methyltransferase (TPMT) enzyme activity and genotype.
  94. ncbi Thiopurine methyltransferase deficiency and azathioprine intolerance in autoimmune hepatitis
    Albert J Czaja
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Dig Dis Sci 51:968-75. 2006
    ..We conclude that routine screening of blood thiopurine methyltransferase levels has a low yield for identifying individual patients at risk for azathioprine toxicity during conventional low dose therapy for autoimmune hepatitis...
  95. ncbi Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase
    Richard M Weinshilboum
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cell Mol Neurobiol 26:539-61. 2006
    ..2. The thiopurine S-methyltransferase (TPMT) genetic polymorphism represents one of the best characterized and most clinically relevant examples of ..
  96. doi Pharmacogenomics of drug-metabolizing enzymes and drug transporters in chemotherapy
    Tessa M Bosch
    Clinical Pharmacy and Toxicology, Medical Center Rijnmond Zuid, Rotterdam, The Netherlands
    Methods Mol Biol 448:63-76. 2008
    ..examples to demonstrate the influence of pharmacogenomics on anticancer therapy are thiopurine methyltransferase (TPMT), UGT (uridine diphosphate glucuronosyltransferase) 1A1*28, and DPD (dihydropyrimidine dehydrogenase) *2A, ..
  97. doi Thiopurine S-methyltransferase genotypic analysis in autoimmune bullous diseases
    Maud Bezier
    Department of Dermatology, Hopital Robert Debre, Centre Hospitalier de Reims, avenue du Général Koenig, 51092 Reims Cedex, France
    Eur J Dermatol 18:512-7. 2008
    Thiopurine S-methyltransferase (TPMT) activity is inversely related to the risk of developing severe hematopoietic toxicity in patients treated with azathioprine...
  98. pmc Molecular dynamics simulation of a human thiopurine S-methyltransferase complexed with 6-mercaptopurine model
    Wanwimon Mokmak
    National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phahonyothin Road, Klong 1, Klongluang, Pathumthani 12120, Thailand
    Bioinformation 4:59-62. 2009
    Human thiopurine S-methyltransferase (TPMT) is an essential protein in 6-mercaptopurine (6MP) drug metabolism...
  99. doi Functional analysis of the role of the TPMT gene promoter VNTR polymorphism in TPMT gene transcription
    Branka Zukic
    Institute for Molecular Genetics and Genetic Engineering, Laboratory of Molecular Hematology, Vojvode Stepe 444a, 11010 Belgrade, Serbia
    Pharmacogenomics 11:547-57. 2010
    Thiopurine S-methyltransferase (TPMT) activity is polymorphic, and a trimodal distribution has been demonstrated in Caucasians (low, intermediate and high methylator groups)...
  100. doi Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis
    Thi Mai Hoang Nguyen
    Universite de Lyon, Département de Pharmacie Clinique, de Pharmacocinétique et d Evaluation du Médicament, Lyon, France
    Ther Drug Monit 32:433-7. 2010
    ..6-Thioguanine nucleotides (6-TGN) and 6-methyl mercaptopurine nucleotides (6-MeMPN) concentrations and TPMT activity were determined by high-performance liquid chromatography...
  101. doi Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene
    Malin Lindqvist Appell
    Department of Medical and Health Sciences, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pharmacogenet Genomics 20:700-7. 2010
    The activity of the human enzyme thiopurine methyltransferase (TPMT) varies greatly between individuals because of genetic polymorphism...

Research Grants10

  1. Multi-site Trial of Azathioprine Dosing in Crohn Disease
    Stephen Hanauer; Fiscal Year: 2003
    ..In a competing enzymatic pathway, thiopurine methyltransferase (TPMT) catalyzes formation of 6-methyl-mercaptopurine ribonucleotides (6-MMPR), metabolites that are therapeutically ..
  2. Multi-site Trial of Azathioprine Dosing in Crohn Disease
    Stephen Hanauer; Fiscal Year: 2004
    ..In a competing enzymatic pathway, thiopurine methyltransferase (TPMT) catalyzes formation of 6-methyl-mercaptopurine ribonucleotides (6-MMPR), metabolites that are therapeutically ..
  3. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..We will control for polymorphisms in TPMT, and other genetic polymorphisms (in transporters, repair enzymes, HPRT, etc...
  4. LC-ELECTROSPRAY QUADRUPOLE ION TRAP MASS SPECTROMETER
    Dominic Desiderio; Fiscal Year: 2000
    ..wild-type and mutant forms of thiopurine methyltransferase (for the investigation of the genetic polymorphism of TPMT); and (lii) mismatch repair proteins (in the study of their involvement in the determination of thiopurine ..
  5. Drug Metabolism, DNA Repair & Second Cancers
    Debra Friedman; Fiscal Year: 2003
    ..The findings of this research can be applied to the development of preventive strategies of second malignant neoplasms and other adverse long-term health-related outcomes for cancer survivors. ..
  6. SULFATE CONJUGATION AND DRUG METABOLISM
    Richard Weinshilboum; Fiscal Year: 2007
    ....
  7. Anticancer Agent Pharmacodynamics in Acute Leukemia
    Mary Relling; Fiscal Year: 2006
    ..We have also identified a clinical genetic host factor, low thiopurine methyltransferase (TPMT) activity, that predisposed patients treated with thiopurines and etoposide to development of topoisomerase II ..
  8. The Natural History of Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..abstract_text> ..
  9. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  10. Metabolism and Pharmacogenetics in MDMA-Induced Toxicity
    Rafael de la Torre; Fiscal Year: 2009
    ..A study will compare MDMA toxicity when co-adminsitered with the MRP1 inhibitor probenecid. ..