Gene Symbol: TPM1
Description: tropomyosin 1
Alias: C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA, tropomyosin alpha-1 chain, alpha-tropomyosin, cardiomyopathy, hypertrophic 3, epididymis secretory protein Li 265, sarcomeric tropomyosin kappa, tropomyosin 1 (alpha)
Species: human
Products:     TPM1

Top Publications

  1. Balvay L, Fiszman M. [Analysis of the diversity of tropomyosin isoforms]. C R Seances Soc Biol Fil. 1994;188:527-40 pubmed
    ..In both cases, alternative splicing involves a combination of negative regulation, on exon 2b in smooth muscle and on exon 6b in non muscle tissues, and of competition in the alternative situation. ..
  2. Thierfelder L, Watkins H, MacRae C, Lamas R, McKenna W, Vosberg H, et al. Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell. 1994;77:701-12 pubmed
    ..Further, because the splice site mutation is predicted to function as a null allele, we suggest that abnormal stoichiometry of sarcomeric proteins can cause cardiac hypertrophy. ..
  3. Brown J, Kim K, Jun G, Greenfield N, Dominguez R, Volkmann N, et al. Deciphering the design of the tropomyosin molecule. Proc Natl Acad Sci U S A. 2001;98:8496-501 pubmed
    ..The seven alanine clusters in the core of the complete molecule (which spans seven monomers of the actin helix) promote the semiflexible winding of the tropomyosin filament necessary for its regulatory role in muscle contraction. ..
  4. Perry S. Vertebrate tropomyosin: distribution, properties and function. J Muscle Res Cell Motil. 2001;22:5-49 pubmed
    ..These isoforms which are expressed by alternative promoters and alternative RNA processing of four genes, TPM1, 2, 3 and 4, all conform to a general pattern of structure...
  5. Zheng Q, Safina A, Bakin A. Role of high-molecular weight tropomyosins in TGF-beta-mediated control of cell motility. Int J Cancer. 2008;122:78-90 pubmed
    ..Thus, these results suggest that HMW-tropomyosins are important for TGF-beta-mediated control of cell motility and acquisition of the metastatic potential. ..
  6. Mathur M, Chase P, Chalovich J. Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin. Biochem Biophys Res Commun. 2011;406:74-8 pubmed publisher
    ..These results suggest that the E180G and D175N mutations reduce the affinity of tropomyosin for actin and also destabilize troponin binding to the actin thin filaments. ..
  7. Bai F, Weis A, Takeda A, Chase P, Kawai M. Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations. Biophys J. 2011;100:1014-23 pubmed publisher
    ..Decreased contractility (T(act)) in V95A and D175N may further contribute to the severity of myocyte hypertrophy and related prognosis of the disease. ..
  8. Jääskeläinen P, Soranta M, Miettinen R, Saarinen L, Pihlajamaki J, Silvennoinen K, et al. The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population. J Am Coll Cardiol. 1998;32:1709-16 pubmed
    ..Our results indicate that the beta-MHC gene is not the predominant gene for HCM in the Finnish population, whereas HCM caused by the Aspl75Asn mutation of the a-TM gene is more common than previously reported. ..
  9. Karibe A, Tobacman L, Strand J, Butters C, Back N, Bachinski L, et al. Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis. Circulation. 2001;103:65-71 pubmed
    We report hypertrophic cardiomyopathy (HCM) in a Spanish-American family caused by a novel alpha-tropomyosin (TPM1) mutation and examine the pathogenesis of the clinical disease by characterizing functional defects in the purified mutant ..

More Information

Publications190 found, 100 shown here

  1. Michele D, Gomez C, Hong K, Westfall M, Metzger J. Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade. Circ Res. 2002;91:255-62 pubmed
    ..In addition, because diastolic dysfunction in E180G Tm mice is dependent on inotropic status, cardiovascular stress may play an important role in FHC pathogenesis. ..
  2. Wernicke D, Thiel C, Duja Isac C, Essin K, Spindler M, Nunez D, et al. alpha-Tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways. Am J Physiol Regul Integr Comp Physiol. 2004;287:R685-95 pubmed
  3. Varga A, Stourman N, Zheng Q, Safina A, Quan L, Li X, et al. Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta. Oncogene. 2005;24:5043-52 pubmed
    ..TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes...
  4. Wang F, Brunet N, Grubich J, Bienkiewicz E, Asbury T, Compton L, et al. Facilitated cross-bridge interactions with thin filaments by familial hypertrophic cardiomyopathy mutations in ?-tropomyosin. J Biomed Biotechnol. 2011;2011:435271 pubmed publisher
    ..When HMM density was reduced, thin filaments with D175N required fewer motors to initiate sliding or achieve maximum sliding speed. ..
  5. Chevray P, Nathans D. Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc Natl Acad Sci U S A. 1992;89:5789-93 pubmed
    ..Our results illustrate the range of protein interaction cloning for discovering proteins that bind to a given target polypeptide. ..
  6. Gooding C, Edge C, Lorenz M, Coelho M, Winters M, Kaminski C, et al. MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3. Nucleic Acids Res. 2013;41:4765-82 pubmed publisher
    Exon 3 of the rat α-tropomyosin (Tpm1) gene is repressed in smooth muscle cells, allowing inclusion of the mutually exclusive partner exon 2...
  7. Bainbridge M, Davis E, Choi W, Dickson A, Martinez H, Wang M, et al. Loss of Function Mutations in NNT Are Associated With Left Ventricular Noncompaction. Circ Cardiovasc Genet. 2015;8:544-52 pubmed publisher
    ..In 4 of 5 families, the candidate causative mutation segregates with disease in known LVNC genes MYH7 and TPM1. Subsequent sequencing of MYH7 in a larger LVNC cohort identified 7 novel likely disease causing variants...
  8. Zhang T, Lin Y, Liu J, Zhang Z, Fu W, Guo L, et al. Rbm24 Regulates Alternative Splicing Switch in Embryonic Stem Cell Cardiac Lineage Differentiation. Stem Cells. 2016;34:1776-89 pubmed publisher
    ..Among the Rbm24-regulated events, Tpm1, an actin filament family gene, was identified to possess ESC/tissue specific isoforms...
  9. Mak A, Smillie L, Barany M. Specific phosphorylation at serine-283 of alpha tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle. Proc Natl Acad Sci U S A. 1978;75:3588-92 pubmed
    ..A single phosphorylation site was located at serine-283 (pentultimate at the COOH-terminal end) of the frog alpha tropomyosin. The same phosphorylated peptide was recovered in low yields from both rabbit skeletal alpha and cardiac ..
  10. Jha P, Leavis P, Sarkar S. Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system. Biochemistry. 1996;35:16573-80 pubmed
    ..Overall, our results also imply that residues 159-201 constitute the smallest region of TnT which contributes to the Ca2+ sensitivity of actoS1 ATPase in a reconstituted regulatory system. ..
  11. Scala E, Alessandri C, Palazzo P, Pomponi D, Liso M, Bernardi M, et al. IgE recognition patterns of profilin, PR-10, and tropomyosin panallergens tested in 3,113 allergic patients by allergen microarray-based technology. PLoS ONE. 2011;6:e24912 pubmed publisher
    ..Allergen microarray IgE testing increases our knowledge of the IgE immune response and related epidemiological features within and between homologous molecules better describing the patients' immunological phenotypes. ..
  12. Shinde V, Brungs S, Henry M, Wegener L, Nemade H, Rotshteyn T, et al. Simulated Microgravity Modulates Differentiation Processes of Embryonic Stem Cells. Cell Physiol Biochem. 2016;38:1483-99 pubmed publisher
    ..Notably, simulated microgravity deregulated genes Cyr61, Thbs1, Parva, Dhrs3, Jun, Tpm1, Fzd2 and Dll1 are involved in heart morphogenesis as an acute response on day 3...
  13. Farman G, Rynkiewicz M, Orzechowski M, Lehman W, Moore J. HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Arch Biochem Biophys. 2018;647:84-92 pubmed publisher
    ..Comparison of wild-type and mutant human α-tropomyosin (Tpm1.1) behavior was carried out using in vitro motility assays and molecular dynamics simulations...
  14. Borovikov Y, Karpicheva O, Chudakova G, Robinson P, Redwood C. Dilated cardiomyopathy mutations in alpha-tropomyosin inhibit its movement during the ATPase cycle. Biochem Biophys Res Commun. 2009;381:403-6 pubmed publisher
    ..The correlation of these structural changes with the observed function effects is discussed. ..
  15. Prunotto M, Bruschi M, Gunning P, Gabbiani G, Weibel F, Ghiggeri G, et al. Stable incorporation of α-smooth muscle actin into stress fibers is dependent on specific tropomyosin isoforms. Cytoskeleton (Hoboken). 2015;72:257-67 pubmed publisher
    ..We find that after TGFβ1 treatment elevated levels of the Tpm1.6/7 isoforms, and to a lesser extent Tpm2.1, precede the increase in α-SMA...
  16. Lynn M, Tal Grinspan L, Holeman T, Jimenez J, Strom J, Tardiff J. The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy. J Mol Cell Cardiol. 2017;108:127-137 pubmed publisher
    ..families identified a novel dilated cardiomyopathy (DCM)-linked mutation in the gene coding for alpha-tropomyosin (TPM1) resulting in the substitution of an aspartic acid for an asparagine (at residue 230)...
  17. Li Y, Ji Y, Zhou X, Li H, Zhang H, Zhang Y, et al. Significance of sarcomere gene mutation in patients with dilated cardiomyopathy. Genet Mol Res. 2015;14:11200-10 pubmed publisher
    ..and polymerase chain reaction amplification was carried out on subject DNA for three candidate genes tropomyosin (TPM1), cardiac troponin T type-2 (TNNT2), and nuclear lamina protein A/C...
  18. Gateva G, Kremneva E, Reindl T, Kotila T, Kogan K, Gressin L, et al. Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro. Curr Biol. 2017;27:705-713 pubmed publisher
    ..this hypothesis, we analyzed the properties of actin filaments decorated by stress-fiber-associated tropomyosins (Tpm1.6, Tpm1.7, Tpm2.1, Tpm3.1, Tpm3.2, and Tpm4.2)...
  19. Jalanko M, Helio T, Mustonen P, Kokkonen J, Huhtala H, Laine M, et al. Novel electrocardiographic features in carriers of hypertrophic cardiomyopathy causing sarcomeric mutations. J Electrocardiol. 2018;51:983-989 pubmed publisher
    ..We studied 140 carriers (G+) of the TPM1-Asp175Asn or MYBPC3-Gln1061X pathogenic variants for HCM: The G+/LVH+ group (n = 98) consisted of mutation ..
  20. Møller D, Andersen P, Hedley P, Ersbøll M, Bundgaard H, Moolman Smook J, et al. The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy. Eur J Hum Genet. 2009;17:1241-9 pubmed publisher
    ..polymorphism and subsequently by bidirectional DNA sequencing of conformers in the coding regions of MYH7, MYBPC3, TPM1, ACTC, MYL2, MYL3, TNNT2, CSRP3 and TNNI3. Eight probands carried disease-associated genetic variants (26%)...
  21. Chang B, Nishizawa T, Furutani M, Fujiki A, Tani M, Kawaguchi M, et al. Identification of a novel TPM1 mutation in a family with left ventricular noncompaction and sudden death. Mol Genet Metab. 2011;102:200-6 pubmed publisher
    ..We screened 4 genes (TAZ, LDB3, DTNA and TPM1) in 51 patients with LVNC for mutations by polymerase chain reaction and direct DNA sequencing...
  22. Subirats X, Rosés M, Bosch E. High-throughput logPo/w determination from UHPLC measurements: Revisiting the chromatographic hydrophobicity index. J Pharm Biomed Anal. 2016;127:26-31 pubmed publisher
    ..Abraham's hydrogen-bond acidity (A) and excess molar refraction (E) from ACD/Labs, and hydrogen-bond acidity HDCA-1/TMSA and HOMO-LUMO polarizability descriptors from CODESSA software...
  23. Cho Y, Liu J, Hitchcock DeGregori S. The amino terminus of muscle tropomyosin is a major determinant for function. J Biol Chem. 1990;265:538-45 pubmed
    ..We suggest that the structure of the amino-terminal region and acetylation of the initial methionine are crucial for tropomyosin function. ..
  24. Harris R, Yang A, Stein R, Lucy K, Brusten L, Herath A, et al. Cluster analysis of an extensive human breast cancer cell line protein expression map database. Proteomics. 2002;2:212-23 pubmed
    ..Mass spectrometry was used to identify the proteins. The possible role of these proteins in cancer is discussed. ..
  25. Morita H, Rehm H, Menesses A, McDonough B, Roberts A, Kucherlapati R, et al. Shared genetic causes of cardiac hypertrophy in children and adults. N Engl J Med. 2008;358:1899-908 pubmed publisher
    ..99+/-6.12 years). We sequenced eight genes: MYH7, MYBPC3, TNNT2, TNNI3, TPM1, MYL3, MYL2, and ACTC. These genes encode sarcomere proteins that, when mutated, cause adult-onset cardiomyopathies...
  26. Kubo E, Hasanova N, Fatma N, Sasaki H, Singh D. Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells. J Cell Mol Med. 2013;17:212-21 pubmed publisher vivo rodent PCO and human cataractous LECs, we demonstrated that the aberrant expression of rat Tpm and human Tpm1?/2? suggested their association in remodelling of the actin cytoskeleton during EMT of LECs...
  27. Bongini C, Ferrantini C, Girolami F, Coppini R, Arretini A, Targetti M, et al. Impact of Genotype on the Occurrence of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy. Am J Cardiol. 2016;117:1151-9 pubmed publisher
    ..3 genetic subgroups: (1) MYBPC3 (58%), (2) MYH7 (28%), and (3) "other genotypes" (14%; comprising TNNT2, TNNI3, TPM1, MYL2, complex genotypes, Z-line, and E-C coupling genes). Left atrial size was similar in the 3 subsets...
  28. Jaafar N, Gomez J, Kammoun I, Zairi I, Amara W, Kachboura S, et al. Spectrum of Mutations in Hypertrophic Cardiomyopathy Genes Among Tunisian Patients. Genet Test Mol Biomarkers. 2016;20:674-679 pubmed generation sequencing of the nine main sarcomeric genes (MYH7, MYBPC3, TNNT2, TNNI3, ACTC1, TNNC1, MYL2, MYL3, TPM1) as well as the recently identified as an HCM gene, FLNC, in 45 Tunisian HCM patients...
  29. Wu Y, Lou Q, Ge F, Xiong Q. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Sci Rep. 2017;7:4022 pubmed publisher
    ..The results showed that genes encoding tropomyosin 1 (tpm1) and poly(rC) binding protein 2 (pcbp2) are direct miR-21 targets...
  30. Colpan M, Ly T, Grover S, Tolkatchev D, Kostyukova A. The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics. Arch Biochem Biophys. 2017;630:18-26 pubmed publisher
    ..The K15N mutation in the TPM1 gene is associated with familial dilated cardiomyopathy (DCM) but the effect of this mutation on Tpm's function is ..
  31. Jääskeläinen P, Miettinen R, Kärkkäinen P, Toivonen L, Laakso M, Kuusisto J. Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes. Ann Med. 2004;36:23-32 pubmed
    ..A previously described alpha-tropomyosin (TPM1) mutation (Asp175Asn) was found in 11% of cases...
  32. Ojala M, Prajapati C, Pölönen R, Rajala K, Pekkanen Mattila M, Rasku J, et al. Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy. Stem Cells Int. 2016;2016:1684792 pubmed publisher
    ..founder mutations for HCM in Finland are located in myosin-binding protein C (MYBPC3-Gln1061X) and α-tropomyosin (TPM1-Asp175Asn) genes...
  33. Chen C, Hsia C, Ho C, Liang C, Chen C, Huang K, et al. Hypoxia and hyperoxia differentially control proliferation of rat neural crest stem cells via distinct regulatory pathways of the HIF1?-CXCR4 and TP53-TPM1 proteins. Dev Dyn. 2017;246:162-185 pubmed publisher
    ..dramatically increased, associated with increased nuclear expression of TP53, decreased cytoplasmic expression of TPM1 (tropomyosin-1), and increased nuclear-to-cytoplasmic translocation of S100A2...
  34. Colote S, Widada J, Ferraz C, Bonhomme F, Marti J, Liautard J. Evolution of tropomyosin functional domains: differential splicing and genomic constraints. J Mol Evol. 1988;27:228-35 pubmed
    ..G + C content is characteristic of a gene and does not change significantly during evolution.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  35. Tuunanen H, Kuusisto J, Toikka J, Jääskeläinen P, Marjamaki P, Peuhkurinen K, et al. Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study. J Nucl Cardiol. 2007;14:354-65 pubmed
    ..Increased metabolism and efficiency characterize patients with mild myocardial hypertrophy. These hypermetabolic alterations regress with advanced hypertrophy. ..
  36. Jääskeläinen P, Helio T, Aalto Setala K, Kaartinen M, Ilveskoski E, Hämäläinen L, et al. Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population. Ann Med. 2013;45:85-90 pubmed publisher
    ..However, two prevalent founder mutations for HCM in the alpha-tropomyosin (TPM1-D175N) and myosin-binding protein C (MYBPC3-Q1061X) genes have previously been identified in eastern Finland...
  37. Da Costa G, Gomig T, Kaviski R, Santos Sousa K, Kukolj C, de Lima R, et al. Comparative Proteomics of Tumor and Paired Normal Breast Tissue Highlights Potential Biomarkers in Breast Cancer. Cancer Genomics Proteomics. 2015;12:251-61 pubmed
    ..spots were common to at least two samples, and the ten proteins with the highest-fold changes were CASPE, ENOG, TPM1, CAPG, VIME, TPM3, TRFE, PDIA6, WDR61 and PDIA3...
  38. Pinheiro V, Carvalho N, Carmo E, Schneider C, Feldberg E, Gross M. Karyoevolution in Potamorhina (Cope, 1878) (Ostariophysi, Curimatidae): Using Repetitive DNA for the Elucidation of Genome Organization. Zebrafish. 2016;13:118-31 pubmed publisher
    ..5S and 18S ribosomal DNA (rDNA), retroelement of Xiphophorus 1 (Rex1), Rex3, telomeres, and tropomyosin 1 (TPM1), we attempted to understand the evolutionary mechanisms involved in the differentiation of the Potamorhina species...
  39. Prajapati C, Ojala M, Aalto Setala K. Divergent effects of adrenaline in human induced pluripotent stem cell-derived cardiomyocytes obtained from hypertrophic cardiomyopathy. Dis Model Mech. 2018;11: pubmed publisher
    ..stem cell-derived cardiomyocytes (hiPSC-CMs) from HCM patients carrying either the MYBPC3-Gln1061X or TPM1-Asp175Asn mutation...
  40. Zou L, Zhang J, Han J, Li W, Su F, Xu X, et al. cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction. Respir Res. 2018;19:201 pubmed publisher
    ..cGMP interacted with tropomyosin. Isoform 4 of TPM1 gene was identified as the only isoform expressed in the human pulmonary artery smooth muscle cells (HPASMCs)...
  41. Olson T, Kishimoto N, Whitby F, Michels V. Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy. J Mol Cell Cardiol. 2001;33:723-32 pubmed
    ..Therefore, substitution of different amino acid residues in the same thin filament proteins is associated with the distinct phenotypes of cardiac hypertrophy or congestive heart failure. ..
  42. Bos J, Theis J, Tajik A, Gersh B, Ommen S, Ackerman M. Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. Am Heart J. 2008;155:1128-34 pubmed publisher
    ..Whereas mutations within the sarcomere appear to dominate the disease process, in their absence, sex has a significant modifying effect, specifically noted in cases of sigmoidal HCM. ..
  43. Kubo E, Shibata S, Shibata T, Kiyokawa E, Sasaki H, Singh D. FGF2 antagonizes aberrant TGF? regulation of tropomyosin: role for posterior capsule opacity. J Cell Mol Med. 2017;21:916-928 pubmed publisher
    ..Stress fibre formation and up-regulation of ?-smooth muscle actin (?SMA) induced by TGF?2 could be reversed by Tpm1/2 knock-down by siRNA. Expression of Tpm1/2 and stress fibre formation induced by TGF?2 could be reversed by FGF2...
  44. Nijak A, Alaerts M, Kuiperi C, Corveleyn A, Suys B, Paelinck B, et al. Left ventricular non-compaction with Ebstein anomaly attributed to a TPM1 mutation. Eur J Med Genet. 2018;61:8-10 pubmed publisher
    ..WES revealed a missense variant (p.Leu113Val) in TPM1 segregating with the LVN(C) phenotype...
  45. Kubo E, Shibata T, Singh D, Sasaki H. Roles of TGF β and FGF Signals in the Lens: Tropomyosin Regulation for Posterior Capsule Opacity. Int J Mol Sci. 2018;19: pubmed publisher
    ..Mouse and rat PCO are accompanied by elevated expression of Tpm2. Further, the expression of Tpm1/2 is induced by TGF β2 in LECs...
  46. Rajan S, Ahmed R, Jagatheesan G, Petrashevskaya N, Boivin G, Urboniene D, et al. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res. 2007;101:205-14 pubmed
    ..As such, this is the first mouse model in which a mutation in a sarcomeric thin filament protein, specifically TM, leads to DCM. ..
  47. Du H, Wang Y, Jiang Y, Wang C, Zhou T, Liu H, et al. Silencing of the TPM1 gene induces radioresistance of glioma U251 cells. Oncol Rep. 2015;33:2807-14 pubmed publisher
    The present study was designed to investigate the relationship between tropomyosin 1 (TPM1) and radioresistance in human U251 cells. Radioresistant U251 (RR-U251) cells were established by repeated small irradiating injury...
  48. Bharadwaj S, Prasad G. Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells. Cancer Lett. 2002;183:205-13 pubmed
    ..These data, for the first time, show that hypermethylation of TM1 gene and chromatin remodeling are the predominant mechanisms by which TM1 expression is downregulated in breast cancer cells. ..
  49. Croft T, James Theoga Raj C, Salemi M, Phinney B, Lin S. A functional link between NAD+ homeostasis and N-terminal protein acetylation in Saccharomyces cerevisiae. J Biol Chem. 2018;293:2927-2938 pubmed publisher
    ..NA/NAM release in NatB mutants was abolished by deleting the autophagy protein ATG14 We next examined Tpm1 (tropomyosin), whose function is regulated by NatB-mediated acetylation, and Tpm1 overexpression (TPM1-oe) ..
  50. Kis Bicskei N, Bécsi B, Erdodi F, Robinson R, Bugyi B, Huber T, et al. Tropomyosins Regulate the Severing Activity of Gelsolin in Isoform-Dependent and Independent Manners. Biophys J. 2018;114:777-787 pubmed publisher
    ..We show that the three investigated tropomyosin isoforms (Tpm1.1, Tpm1.12, and Tpm3.1) bind to gelsolin with micromolar or submicromolar affinities...
  51. Brown H, Schachat F. Renaturation of skeletal muscle tropomyosin: implications for in vivo assembly. Proc Natl Acad Sci U S A. 1985;82:2359-63 pubmed
    ..Based on the density of sequence substitutions between the alpha and beta subunits, that region probably includes residues 36-64. ..
  52. Rynkiewicz M, Fischer S, Lehman W. The propensity for tropomyosin twisting in the presence and absence of F-actin. Arch Biochem Biophys. 2016;609:51-58 pubmed publisher
    A canonical model of muscle ?-tropomyosin (Tpm1.1), based on molecular-mechanics and electron microscopy of different contractile states, shows that the two-stranded coiled-coiled is pre-bent to present a specific molecular-face to the F-..
  53. Houle F, Rousseau S, Morrice N, Luc M, Mongrain S, Turner C, et al. Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing. Mol Biol Cell. 2003;14:1418-32 pubmed
  54. Janco M, Bonello T, Byun A, Coster A, Lebhar H, Dedova I, et al. The impact of tropomyosins on actin filament assembly is isoform specific. Bioarchitecture. 2016;6:61-75 pubmed publisher
    ..Therefore, we purified and characterized a comprehensive set of 8 Tpm isoforms (Tpm1.1, Tpm1.12, Tpm1.6, Tpm1.7, Tpm1.8, Tpm2.1, Tpm3.1, and Tpm4...
  55. Sckolnick M, Krementsova E, Warshaw D, Trybus K. Tropomyosin isoforms bias actin track selection by vertebrate myosin Va. Mol Biol Cell. 2016;27:2889-97 pubmed publisher
    ..Actin-Tpm3.1 and actin-Tpm1.8 were equal or better tracks compared to bare actin for myoVa-HMM based on event frequency, run length, and speed...
  56. Viana P, Ezaz T, Marajó L, Ferreira M, Zuanon J, Cioffi M, et al. Genomic Organization of Repetitive DNAs and Differentiation of an XX/XY Sex Chromosome System in the Amazonian Puffer Fish, Colomesus asellus (Tetraodontiformes). Cytogenet Genome Res. 2017;: pubmed publisher
    ..FISH with telomeric and tropomyosin (tpm1) sequences, respectively, revealed terminal signals in all chromosomes...
  57. Li J, Huang H, Sun L, Yang M, Pan C, Chen W, et al. MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. Clin Cancer Res. 2009;15:3998-4008 pubmed publisher
    ..We aim to examine miR-21 expression in tongue squamous cell carcinomas (TSCC) and correlate it with patient clinical status, and to investigate its contribution to TSCC cell growth, apoptosis, and tumorigenesis...
  58. Geeves M, Hitchcock Degregori S, Gunning P. A systematic nomenclature for mammalian tropomyosin isoforms. J Muscle Res Cell Motil. 2015;36:147-53 pubmed publisher
    ..The National Center for Biotechnology Information (NCBI) website has been amended to include the nomenclature for the human, mouse and rat genes. ..
  59. Zhao Y, Cao H, Song Y, Feng Y, Ding X, Pang M, et al. Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system. Int J Mol Med. 2016;37:1511-20 pubmed publisher
    ..troponin T type 2 (cardiac) (TNNT2); actin, ?, cardiac muscle 1 (ACTC1); tropomyosin 1 (?) (TPM1); sodium channel, voltage gated, type V alpha subunit (SCN5A); myosin, light chain 2, regulatory, cardiac, slow ..
  60. Patchell V, Gallon C, Evans J, Gao Y, Perry S, Levine B. The regulatory effects of tropomyosin and troponin-I on the interaction of myosin loop regions with F-actin. J Biol Chem. 2005;280:14469-75 pubmed
    ..We suggest that the role of tropomyosin is to facilitate the transmission of structural changes along the F-actin filament so that the monomers within a structural unit are able to interact with myosin. ..
  61. Watakabe A, Kobayashi R, Helfman D. N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin. J Cell Sci. 1996;109 ( Pt 9):2299-310 pubmed
    ..The neuron-specific expression of N-tropomodulin strongly suggests specialized roles of this TM-binding protein in neurons. ..
  62. Alioto S, Garabedian M, Bellavance D, Goode B. Tropomyosin and Profilin Cooperate to Promote Formin-Mediated Actin Nucleation and Drive Yeast Actin Cable Assembly. Curr Biol. 2016;26:3230-3237 pubmed publisher
    ..We addressed this question in S. cerevisiae, where tropomyosins (Tpm1 and Tpm2), profilin (Pfy1), and formins (Bni1 and Bnr1) are required for the assembly of an array of actin cables ..
  63. Novy R, Lin J, Lin C, Lin J. Human fibroblast tropomyosin isoforms: characterization of cDNA clones and analysis of tropomyosin isoform expression in human tissues and in normal and transformed cells. Cell Motil Cytoskeleton. 1993;25:267-81 pubmed
    ..However, there was no detectable expression of this exon in stomach and skeletal muscle. The difference in tissue-specific expression suggests that different isoforms may perform distinct functions in different tissues. ..
  64. Pawlak G, McGarvey T, Nguyen T, Tomaszewski J, Puthiyaveettil R, Malkowicz S, et al. Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder. Int J Cancer. 2004;110:368-73 pubmed
    ..We conclude that alterations in TM isoform expression may provide further insight into malignant transformation in transitional cell carcinomas of the bladder and may be a useful target for early detection strategies. ..
  65. Yang J, Zhu M, Wang Y, Hou X, Wu H, Wang D, et al. Whole-exome sequencing identify a new mutation of MYH7 in a Chinese family with left ventricular noncompaction. Gene. 2015;558:138-42 pubmed publisher
    ..Previous reports show that defects in TAZ, SCN5A, TPM1, YWHAE, MYH7, ACTC1 and TNNT2 are associated with LVNC...
  66. Wang J, Guan J, Lu Z, Jin J, Cai Y, Wang C, et al. Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma. Oncol Rep. 2015;33:1326-34 pubmed publisher
    ..One of its isoforms, tropomyosin-1 (TPM1) has been reported as a novel tumor-suppressor gene and is downregulated in many solid tumors...
  67. Nan C, Dube S, Matoq A, Mikesell L, Abbott L, Alshiekh Nasany R, et al. Expression of sarcomeric tropomyosin in striated muscles in axolotl treated with shz-1, a small cardiogenic molecule. Cardiovasc Toxicol. 2015;15:29-40 pubmed publisher
    ..Shz-1 augments the expression of transcripts of the total sarcomeric TPM1 (both TPM1? & TPM1?) and sarcomeric TPM4?...
  68. Xia Y, Wang T, Sun H, Liang J, Kuang H. Gas chromatography-mass spectrometry-based trimethylsilyl-alditol derivatives for quantitation and fingerprint analysis of Anemarrhena asphodeloides Bunge polysaccharides. Carbohydr Polym. 2018;198:155-163 pubmed publisher
    Here we report a novel approach using gas chromatography mass spectrometry (GCMS)-based trimethylsilyl-alditol (TMSA) derivatives for simultaneous baseline separation and detection of 8 neutral saccharides and 2 uronic acids within 25 ..
  69. Shoeman R, Sachse C, Höner B, Mothes E, Kaufmann M, Traub P. Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin. Am J Pathol. 1993;142:221-30 pubmed
    ..Nonmuscle myosin heavy chains were also cleaved by this enzyme in vitro. These data demonstrate that this protease can cause alterations in muscle cell ultrastructure in vitro that may be of clinical relevance in infected individuals. ..
  70. Li Q, Dai Y, Guo L, Liu Y, Hao C, Wu G, et al. Polycystin-2 associates with tropomyosin-1, an actin microfilament component. J Mol Biol. 2003;325:949-62 pubmed
  71. Kaski J, Syrris P, Esteban M, Jenkins S, Pantazis A, Deanfield J, et al. Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy. Circ Cardiovasc Genet. 2009;2:436-41 pubmed publisher
    ..The protein-coding sequences of 9 sarcomere protein genes (MYH7, MYBPC3, TNNI3, TNNT2, TPM1, MYL2, MYL3, ACTC, and TNNC1), the genes encoding desmin (DES), and the gamma-2 subunit of AMP kinase (PRKAG2) were ..
  72. Li X, Suphamungmee W, Janco M, Geeves M, Marston S, Fischer S, et al. The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy. Biochem Biophys Res Commun. 2012;424:493-6 pubmed publisher
  73. Valderrama García B, Rodríguez Alba E, Morales Espinoza E, Moineau Chane Ching K, Rivera E. Synthesis and Characterization of Novel Polythiophenes Containing Pyrene Chromophores: Thermal, Optical and Electrochemical Properties. Molecules. 2016;21:172 pubmed publisher
    A novel series of pyrene containing thiophene monomers TPM1-5 were synthesized and fully characterized by FTIR, MS, ¹H- and (13)C-NMR spectroscopy; their thermal properties were determined by TGA and DSC...
  74. Brayford S, Bryce N, Schevzov G, Haynes E, Bear J, Hardeman E, et al. Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge. Curr Biol. 2016;26:1312-8 pubmed publisher
    ..RNAi-mediated silencing of Tpm1.8/9 led to an increase of Arp2/3 accumulation at the cell periphery and a decrease in the persistence of ..
  75. Raval G, Bharadwaj S, Levine E, Willingham M, Geary R, Kute T, et al. Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors. Oncogene. 2003;22:6194-203 pubmed
    ..Downregulation of TM1 in breast tumors may destabilize microfilament architecture and confer resistance to anoikis, which facilitates survival of neoplastic cells outside the normal microenvironment and promote malignant growth. ..
  76. Andersen P, Havndrup O, Hougs L, Sørensen K, Jensen M, Larsen L, et al. Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in Danish hypertrophic cardiomyopathy patients and relatives. Hum Mutat. 2009;30:363-70 pubmed publisher
    ..patients were screened for mutations in all coding regions of 10 sarcomere genes (MYH7, MYL3, MYBPC3, TNNI3, TNNT2, TPM1, ACTC, CSRP3, TCAP, and TNNC1) and five exons of TTN...
  77. Li J, Li H, Tian Y, Yang Y, Chen G, Guo W, et al. Cytoskeletal binding proteins distinguish cultured dental follicle cells and periodontal ligament cells. Exp Cell Res. 2016;345:6-16 pubmed publisher
    ..Upon validation by real-time PCR, western blotting, and immunofluorescence staining. Tropomyosin 1 (TPM1) and caldesmon 1 (CALD1) were expressed higher in PDLCs than in DFCs...
  78. Lees Miller J, Helfman D. The molecular basis for tropomyosin isoform diversity. Bioessays. 1991;13:429-37 pubmed
    ..In multicellular animals, they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its possible significance to cellular function...
  79. Núñez L, Gimeno Blanes J, Rodriguez Garcia M, Monserrat L, Zorio E, Coats C, et al. Somatic MYH7, MYBPC3, TPM1, TNNT2 and TNNI3 mutations in sporadic hypertrophic cardiomyopathy. Circ J. 2013;77:2358-65 pubmed
    ..basis of HCM lead to the identification of several genes encoding sarcomeric proteins, such as MYH7, MYBPC3, TPM1, TNNT2, and TNNI3...
  80. Ma J, Liu F, Du X, Ma D, Xiong L. Changes in lncRNAs and related genes in ?-thalassemia minor and ?-thalassemia major. Front Med. 2017;11:74-86 pubmed publisher
    ..selected five lncRNAs that displayed altered expressions (DQ583499, X-inactive specific transcript (Xist), lincRNA-TPM1, MRFS16P, and lincRNA-RUNX2-2) and confirmed their expression levels in all samples using real-time polymerase ..
  81. Girolami F, Ho C, Semsarian C, Baldi M, Will M, Baldini K, et al. Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. J Am Coll Cardiol. 2010;55:1444-53 pubmed publisher
    ..regulatory and essential light chains (MYL2, MYL3), troponin-T (TNNT2), troponin-I (TNNI3), alpha-tropomyosin (TPM1), and actin (ACTC). Of the 488 index patients, 4 (0...
  82. Borovikov Y, Avrova S, Karpicheva O, Robinson P, Redwood C. The effect of the dilated cardiomyopathy-causing Glu40Lys TPM1 mutation on actin-myosin interactions during the ATPase cycle. Biochem Biophys Res Commun. 2011;411:496-500 pubmed publisher
    ..These structural changes are likely to underlie the contractile deficit observed in human dilated cardiomyopathy. ..
  83. Kieffer Kwon P, Happel C, Uldrick T, Ramalingam D, Ziegelbauer J. KSHV MicroRNAs Repress Tropomyosin 1 and Increase Anchorage-Independent Growth and Endothelial Tube Formation. PLoS ONE. 2015;10:e0135560 pubmed publisher
    ..and proteomic studies predicted that multiple splice variants of the tumor suppressor protein tropomyosin 1 (TPM1) were targets of KSHV microRNAs...
  84. Tanokura M, Ohtsuki I. Interactions among chymotryptic troponin T subfragments, tropomyosin, troponin I and troponin C. J Biochem. 1984;95:1417-21 pubmed
    ..0 M NaCl, in the presence and absence of Ca2+ ion. On the basis of these findings, the interactions among troponin components and tropomyosin are discussed. ..
  85. Møller D, Pham T, Gustafsson F, Hedley P, Ersbøll M, Bundgaard H, et al. The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy. Eur J Heart Fail. 2009;11:1031-5 pubmed publisher
  86. Wang M, Li W, Chang G, Ye C, Ou J, Li X, et al. MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities. Arterioscler Thromb Vasc Biol. 2011;31:2044-53 pubmed publisher
    ..The hypoxia inducible factor-1 ?/miR-21/tropomyosin 1 pathway may play a critical role in the pathogenesis of ASO. These findings might provide a new therapeutic target for human ASO. ..
  87. Marttila M, Hanif M, Lemola E, Nowak K, Laitila J, Grönholm M, et al. Nebulin interactions with actin and tropomyosin are altered by disease-causing mutations. Skelet Muscle. 2014;4:15 pubmed publisher
    ..We demonstrate for the first time the existence of direct tropomyosin-nebulin interactions in vitro, and show that nebulin interactions with actin and tropomyosin are altered by disease-causing mutations in nebulin and tropomyosin. ..
  88. Gupte T, Haque F, Gangadharan B, Sunitha M, Mukherjee S, Anandhan S, et al. Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies. J Biol Chem. 2015;290:7003-15 pubmed publisher
    ..Among those are 30 single-residue mutations in TPM1, the gene encoding α-tropomyosin...
  89. Borovikov Y, Rysev N, Karpicheva O, Redwood C. Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle. Biochem Biophys Res Commun. 2011;407:197-201 pubmed publisher
    ..These structural changes to the thin filament are likely to underlie the observed increased Ca(2+)-sensitivity caused by these mutations which initiates the disease remodeling. ..
  90. Ponzio G, Rezzonico R, Bourget I, Allan R, Nottet N, Popa A, et al. A new long noncoding RNA (lncRNA) is induced in cutaneous squamous cell carcinoma and down-regulates several anticancer and cell differentiation genes in mouse. J Biol Chem. 2017;292:12483-12495 pubmed publisher
    ..i>Cgref1, Brsk1, Basp1, Dusp5, Btg2, Anpep, Dhrs9, Stfa2, Tpm1, SerpinB2, Cpa4, Crct1, Cryab, Il24, Csf2, and Rgs16 ..
  91. Pearlstone J, Smillie L. Effects of troponin-I plus-C on the binding of troponin-T and its fragments to alpha-tropomyosin. Ca2+ sensitivity and cooperativity. J Biol Chem. 1983;258:2534-42 pubmed
    ..These results suggest that cooperativity exists between the two sites, presumably induced by the binding of troponin-I to tropomyosin and mediated by a conformational change in the latter. ..