TPI1

Summary

Gene Symbol: TPI1
Description: triosephosphate isomerase 1
Alias: HEL-S-49, TIM, TPI, TPID, triosephosphate isomerase, epididymis secretory protein Li 49, triose-phosphate isomerase
Species: human
Products:     TPI1

Top Publications

  1. Olah J, Orosz F, Keseru G, Kovári Z, Kovacs J, Hollan S, et al. Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease. Biochem Soc Trans. 2002;30:30-8 pubmed
    ..Of the several well-established glycolytic enzyme deficiencies, triosephosphate isomerase (TPI) deficiency is the only one in which haemolytic anaemia is coupled with progressive, severe ..
  2. Daar I, Artymiuk P, Phillips D, Maquat L. Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme. Proc Natl Acad Sci U S A. 1986;83:7903-7 pubmed
    Triose-phosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketol-isomerase, EC 5.3.1.1) deficiency is a recessive disorder that results in hemolytic anemia and neuromuscular dysfunction...
  3. Brown J, Daar I, Krug J, Maquat L. Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. Mol Cell Biol. 1985;5:1694-706 pubmed
    The functional gene and three intronless pseudogenes for human triosephosphate isomerase were isolated from a recombinant DNA library and characterized in detail. The functional gene spans 3.5 kilobase pairs and is split into seven exons...
  4. Chang M, Artymiuk P, Wu X, Hollan S, Lammi A, Maquat L. Human triosephosphate isomerase deficiency resulting from mutation of Phe-240. Am J Hum Genet. 1993;52:1260-9 pubmed
    b>Triosephosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketolisomerase [E.C.5.3.1.1]) deficiency is an autosomal recessive disorder that typically results in chronic, nonspherocytic hemolytic anemia and in neuromuscular impairment...
  5. Watanabe M, Zingg B, Mohrenweiser H. Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus. Am J Hum Genet. 1996;58:308-16 pubmed
    Individuals with 50% of expected triosephosphate isomerase (TPI) enzyme activity have been previously identified in families during the screening of approximately 2,000 newborn children for quantitative variation in activity of 12 ..
  6. Arya R, Lalloz M, Bellingham A, Layton D. Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency. Hum Mutat. 1997;10:290-4 pubmed
    b>Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disorder of glycolysis characterized by multisystem disease and lethality in early childhood...
  7. Orosz F, Olah J, Alvarez M, Keseru G, Szabo B, Wagner G, et al. Distinct behavior of mutant triosephosphate isomerase in hemolysate and in isolated form: molecular basis of enzyme deficiency. Blood. 2001;98:3106-12 pubmed
    In a Hungarian family with severe decrease in triosephosphate isomerase (TPI) activity, 2 germ line-identical but phenotypically differing compound heterozygote brothers inherited 2 independent (Phe240Leu and Glu145stop codon) mutations...
  8. Jung J, Yoon T, Choi E, Lee K. Interaction of cofilin with triose-phosphate isomerase contributes glycolytic fuel for Na,K-ATPase via Rho-mediated signaling pathway. J Biol Chem. 2002;277:48931-7 pubmed
    ..by the p160 Rho-associated kinase inhibitor Y-27632, suggesting that the phosphorylated form of cofilin bound to TPI interacts with Na,K-ATPase...
  9. Ralser M, Nebel A, Kleindorp R, Krobitsch S, Lehrach H, Schreiber S, et al. Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans. BMC Genet. 2008;9:38 pubmed publisher
    b>Triosephosphate isomerase (TPI) is a central and conserved glycolytic enzyme. In humans, TPI is encoded by a single gene on 12p13, and associated with a rare genetic disorder, TPI deficiency...

More Information

Publications119 found, 100 shown here

  1. Perry B, Mohrenweiser H. Human triosephosphate isomerase: substitution of Arg for Gly at position 122 in a thermolabile electromorph variant, TPI-Manchester. Hum Genet. 1992;88:634-8 pubmed
    ..transition causing a replacement of Gly 122 with Arg in an electrophoretic mobility variant of human triosephosphate isomerase, TPI-Manchester...
  2. Orosz F, Wagner G, Liliom K, Kovacs J, Baróti K, Horanyi M, et al. Enhanced association of mutant triosephosphate isomerase to red cell membranes and to brain microtubules. Proc Natl Acad Sci U S A. 2000;97:1026-31 pubmed
    In a Hungarian family with triosephosphate isomerase (TPI; D-glyceraldehyde-3-phosphate keto-isomerase, EC 5.3.1...
  3. Olah J, Orosz F, Puskas L, Hackler L, Horanyi M, Polgar L, et al. Triosephosphate isomerase deficiency: consequences of an inherited mutation at mRNA, protein and metabolic levels. Biochem J. 2005;392:675-83 pubmed
    b>Triosephosphate isomerase (TPI) deficiency is a unique glycolytic enzymopathy coupled with neurodegeneration...
  4. Ralser M, Heeren G, Breitenbach M, Lehrach H, Krobitsch S. Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes. PLoS ONE. 2006;1:e30 pubmed
    b>Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disorder caused by various mutations in the gene encoding the key glycolytic enzyme TPI...
  5. Scorza A, Lappin M. Prevalence of Selected Zoonotic and Vector-Borne Agents in Dogs and Cats on the Pine Ridge Reservation. Vet Sci. 2017;4: pubmed publisher
    ..PCR was performed on Giardia [beta-giardin (bg), triose phosphate isomerase (tpi), glutamate dehydrogenase genes (gdh)] and Cryptosporidium [heat shock protein-70 gene (hsp)]..
  6. Koehler A, Rashid M, Zhang Y, Vaughan J, Gasser R, Jabbar A. First cross-sectional, molecular epidemiological survey of Cryptosporidium, Giardia and Enterocytozoon in alpaca (Vicugna pacos) in Australia. Parasit Vectors. 2018;11:498 pubmed publisher
    ..ribosomal RNA (SSU) and 60-kilodalton glycoprotein (gp60) genes for Cryptosporidium, triose-phosphate isomerase (tpi) gene for Giardia duodenalis and the internal transcribed spacer region (ITS) for Enterocytozoon bieneusi...
  7. Kostopoulou D, Casaert S, Tzanidakis N, van Doorn D, Demeler J, von Samson Himmelstjerna G, et al. The occurrence and genetic characterization of Cryptosporidium and Giardia species in foals in Belgium, The Netherlands, Germany and Greece. Vet Parasitol. 2015;211:170-4 pubmed publisher
    ..gene and the heat shock protein (HSP70) gene for Cryptosporidium and on the β-giardin gene and the triose phosphate isomerase (TPI) gene for Giardia...
  8. Youneszadeh Fashalami M, Salati A, Keyvanshokooh S. Comparison of proteomic profiles in the ovary of Sterlet sturgeon (Acipenser ruthenus) during vitellogenic stages. Comp Biochem Physiol Part D Genomics Proteomics. 2018;27:23-29 pubmed publisher
    ..constitutive photomorphogenesis 9 and Ybx2), 20% in metabolism and energy production (triose-phosphate isomerase (TPI)) and 10% in transport (glycolipid transfer protein)...
  9. Squire S, Yang R, Robertson I, Ayi I, Ryan U. Molecular characterization of Cryptosporidium and Giardia in farmers and their ruminant livestock from the Coastal Savannah zone of Ghana. Infect Genet Evol. 2017;55:236-243 pubmed publisher
    ..Giardia positives were typed at the triose phosphate isomerase (tpi), beta-giardin (bg) and gdh loci. The prevalence of Cryptosporidium and Giardia by qPCR was 8...
  10. Wang T, Fan Y, Koehler A, Ma G, Li T, Hu M, et al. First survey of Cryptosporidium, Giardia and Enterocytozoon in diarrhoeic children from Wuhan, China. Infect Genet Evol. 2017;51:127-131 pubmed publisher
    ..the 60kDa glycoprotein (gp60), the internal transcribed spacer of nuclear ribosomal DNA (ITS) and/or the triose phosphate isomerase (tpi) genes as markers. Cryptosporidium meleagridis subtype IIIb (10/500, 2...
  11. Wegayehu T, Karim M, Li J, Adamu H, Erko B, Zhang L, et al. Multilocus genotyping of Giardia duodenalis isolates from children in Oromia Special Zone, central Ethiopia. BMC Microbiol. 2016;16:89 pubmed publisher
    ..Fifteen of them were new genotypes: 5 at the triose phosphate isomerase (tpi), 2 at the ?-giardin (bg), and 8 at the glutamate dehydrogenase (gdh) genes...
  12. Semkiv M, Dmytruk K, Abbas C, Sibirny A. Metabolic engineering for high glycerol production by the anaerobic cultures of Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2017;101:4403-4416 pubmed publisher
    ..glycerol production and accumulation from glucose, we lowered the expression of TPI1 gene coding for triose phosphate isomerase; overexpressed the fused gene consisting the GPD1 and GPP2 parts coding for glycerol-3-phosphate ..
  13. Qi M, Yu F, Li S, Wang H, Luo N, Huang J, et al. Multilocus genotyping of potentially zoonotic Giardia duodenalis in pet chinchillas (Chinchilla lanigera) in China. Vet Parasitol. 2015;208:113-7 pubmed publisher
    ..Genotyping at the subtype level using multiple genes (glutamate dehydrogenase (gdh), triose phosphate isomerase (tpi) and β-giardin (bg) genes) determined that the majority of assemblage A isolate sequences were ..
  14. Hipkiss A. Glycotoxins: Dietary and Metabolic Origins; Possible Amelioration of Neurotoxicity by Carnosine, with Special Reference to Parkinson's Disease. Neurotox Res. 2018;34:164-172 pubmed publisher
    ..to activity-induced deamidation of certain asparagine residues in the glycolytic enzyme triose-phosphate isomerase (TPI)...
  15. Nooshadokht M, Kalantari Khandani B, Sharifi I, Kamyabi H, Liyanage N, Lagenaur L, et al. Stool antigen immunodetection for diagnosis of Giardia duodenalis infection in human subjects with HIV and cancer. J Microbiol Methods. 2017;141:35-41 pubmed publisher
    ..Further multilocus molecular analyses using glutamate dehydrogenase (gdh) and triose phosphate isomerase (tpi) loci demonstrated that the AI genotype of G...
  16. Lee M, Auer H, Lindo J, Walochnik J. Multilocus sequence analysis of Giardia spp. isolated from patients with diarrhea in Austria. Parasitol Res. 2017;116:477-481 pubmed publisher
    ..were subjected to DNA isolation and nested PCR targeting fragments of the glutamate dehydrogenase (gdh), triose phosphate isomerase (tpi), and beta-gardin (bg) genes...
  17. Pipiková J, Papajová I, Majlathova V, Soltys J, Bystrianska J, Schusterová I, et al. First report on Giardia duodenalis assemblage F in Slovakian children living in poor environmental conditions. J Microbiol Immunol Infect. 2018;: pubmed publisher
    ..Molecular characterization of G. duodenalis was performed by sequence analysis of triose phosphate isomerase gene (tpi) and glutamate dehydrogenase gene (gdh). G. duodenalis DNA was detected in 21 samples (6...
  18. Kim G, Seo J, Yum H, Jeong J, Yang H. Protein markers for discrimination of meat species in raw beef, pork and poultry and their mixtures. Food Chem. 2017;217:163-170 pubmed publisher
    ..We confirmed that troponin I (TnI), enolase 3, l-lactate dehydrogenase (LDH) and triose-phosphate isomerase (TPI) could be useful markers for discrimination of mammals from poultry due to their different electrophoretic mobility...
  19. Zhao G, Du S, Wang H, Hu X, Deng M, Yu S, et al. First report of zoonotic Cryptosporidium spp., Giardia intestinalis and Enterocytozoon bieneusi in golden takins (Budorcas taxicolor bedfordi). Infect Genet Evol. 2015;34:394-401 pubmed publisher
    ..Intra-variations were observed at triose phosphate isomerase (tpi), beta giardin (bg) and glutamate dehydrogenase (gdh) loci within the assemblage E, showing seven, ..
  20. Mbae C, Mulinge E, Guleid F, Wainaina J, Waruru A, Njiru Z, et al. Molecular Characterization of Giardia duodenalis in Children in Kenya. BMC Infect Dis. 2016;16:135 pubmed publisher
    ..were identified as Giardia positive samples and were genotyped using glutamate dehydrogenase (gdh), triose phosphate isomerase (tpi) and ?-giardin loci. The three markers successfully genotyped 72 isolates and grouped 2 (1...
  21. Aguiar J, Silva S, Santos V, Rossa G, Taniwaki S, Gregori F, et al. Multilocus amplification of genomic DNA from single cysts of Giardia duodenalis separated using micromanipulation technique. Exp Parasitol. 2015;157:84-7 pubmed publisher
    ..The following loci were detected: beta giardin (bg), GLORF-C4 (orfC4), triose phosphate isomerase (tpi) and glutamate dehydrogenase (gdh)...
  22. Inpankaew T, Schär F, Odermatt P, Dalsgaard A, Chimnoi W, Khieu V, et al. Low risk for transmission of zoonotic Giardia duodenalis from dogs to humans in rural Cambodia. Parasit Vectors. 2014;7:412 pubmed publisher
    ..Molecular characterisation of the small subunit of ribosomal RNA (SSU rRNA) gene, triose phosphate isomerase (TPI) gene and sub-assemblage characterisation of the glutamate dehydrogenase (gdh) gene placed 27...
  23. Qi M, Dong H, Wang R, Li J, Zhao J, Zhang L, et al. Infection rate and genetic diversity of Giardia duodenalis in pet and stray dogs in Henan Province, China. Parasitol Int. 2016;65:159-62 pubmed publisher
    ..All G. duodenalis-positive isolates were characterized at the triose phosphate isomerase (tpi), glutamate dehydrogenase (gdh), and β-giardin (bg) loci, and 37, 51, and 48 sequences were ..
  24. Hinge V, Patil H, Nadaf A. Aroma volatile analyses and 2AP characterization at various developmental stages in Basmati and Non-Basmati scented rice (Oryza sativa L.) cultivars. Rice (N Y). 2016;9:38 pubmed publisher
    ..dehydrogenase 2 (badh2) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and elevated level of triose phosphate isomerase (TPI) and ?1-Pyrolline-5-carboxylic acid synthetase (P5CS) transcript enhances 2AP accumulation...
  25. Cui Y, Wu Q, Yang M, Cui F. Three-dimensional excitation-emission matrix fluorescence spectroscopy and fractions of dissolved organic matter change in landfill leachate by biological treatment. Environ Sci Pollut Res Int. 2016;23:793-9 pubmed publisher
    ..The EEM of leachate and SBR effluent showed that HPO-A and TPI-A were appeared in the peak C, while the HPI, HPO-N, and TPI-N could not be found due to dilution...
  26. Bautista M, Bonatti T, Fiuza V, Terashima A, Canales Ramos M, José J, et al. Occurrence and molecular characterization of Giardia duodenalis cysts and Cryptosporidium oocysts in raw water samples from the Rímac River, Peru. Environ Sci Pollut Res Int. 2018;25:11454-11467 pubmed publisher
    ..For molecular characterization, tpi and bg gene fragments and 18S rRNA were amplified by nested PCR for Giardia and Cryptosporidium, respectively, ..
  27. Ankarklev J, Lebbad M, Einarsson E, Franzén O, Ahola H, Troell K, et al. A novel high-resolution multilocus sequence typing of Giardia intestinalis Assemblage A isolates reveals zoonotic transmission, clonal outbreaks and recombination. Infect Genet Evol. 2018;60:7-16 pubmed publisher
    ..in a Swedish day-care center, showed full complementarity at nine genetic loci (the six new and the standard BG, TPI and GDH loci), strongly suggesting one source of infection...
  28. Rodríguez Almazán C, Arreola R, Rodriguez Larrea D, Aguirre López B, de Gomez Puyou M, Perez Montfort R, et al. Structural basis of human triosephosphate isomerase deficiency: mutation E104D is related to alterations of a conserved water network at the dimer interface. J Biol Chem. 2008;283:23254-63 pubmed publisher
    Human triosephosphate isomerase deficiency is a rare autosomal disease that causes premature death of homozygous individuals...
  29. Tajes M, Guivernau B, Ramos Fernández E, Bosch Morató M, Palomer E, Guix F, et al. The pathophysiology of triose phosphate isomerase dysfunction in Alzheimer's disease. Histol Histopathol. 2013;28:43-51 pubmed publisher
    ..One of the most nitrotyrosinated proteins in AD is the enzyme triosephosphate isomerase (TPI) that isomerises trioses, regulating glucose consumption by both phosphate pentose and glycolytic ..
  30. Tajes M, Eraso Pichot A, Rubio Moscardo F, Guivernau B, Ramos Fernández E, Bosch Morató M, et al. Methylglyoxal produced by amyloid-? peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease. J Alzheimers Dis. 2014;41:273-88 pubmed publisher
    ..One of the most strongly nitrotyrosinated proteins in AD is the triosephosphate isomerase (TPI) enzyme which regulates glycolytic flow, and its efficiency decreased when it is nitrotyrosinated...
  31. Lin H, Dong Y, Shen Y, Zeitler J. Quantifying Pharmaceutical Film Coating with Optical Coherence Tomography and Terahertz Pulsed Imaging: An Evaluation. J Pharm Sci. 2015;104:3377-85 pubmed publisher
    ..paper evaluates tablets with a range of film coating thickness measured using OCT and terahertz pulsed imaging (TPI) in an off-line setting...
  32. Oor J, Ãœnlü Ã, Hazebroek E. A systematic review of the treatment for abdominal cutaneous nerve entrapment syndrome. Am J Surg. 2016;212:165-74 pubmed publisher
    ..Seven studies were included; describing trigger point injection (TPI) or anterior neurectomy as stand-alone procedure, TPI followed by anterior neurectomy as stepwise regimen, and ..
  33. Roland B, Zeccola A, Larsen S, Amrich C, Talsma A, Stuchul K, et al. Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics. PLoS Genet. 2016;12:e1005941 pubmed publisher
    b>Triosephosphate isomerase (TPI) deficiency is a poorly understood disease characterized by hemolytic anemia, cardiomyopathy, neurologic dysfunction, and early death...
  34. Avizcuri J, Sáenz Navajas M, Echávarri J, Ferreira V, Fernández Zurbano P. Evaluation of the impact of initial red wine composition on changes in color and anthocyanin content during bottle storage. Food Chem. 2016;213:123-134 pubmed publisher
    Sixteen commercial red wines, selected to cover a different range of color and total polyphenols index (TPI), were stored at 25°C during 6months under controlled and different oxygen additions (0, 1.1, 3.1, 10.6 and 30...
  35. Chen T, Huang Z, Tian Y, Lin B, He R, Wang H, et al. Clinical significance and prognostic value of Triosephosphate isomerase expression in gastric cancer. Medicine (Baltimore). 2017;96:e6865 pubmed publisher
    b>Triosephosphate isomerase (TPI) is highly expressed in many human cancers and is involved in migration and invasion of cancer cells...
  36. Nunes B, Calegar D, Pavan M, Jaeger L, Monteiro K, Dos Reis E, et al. Genetic diversity of Giardia duodenalis circulating in three Brazilian biomes. Infect Genet Evol. 2018;59:107-112 pubmed publisher
    ..giardin (βG, N = 71), glutamate dehydrogenase (GDH, N = 42), and triosephosphate isomerase (TPI, N = 27). Overall detection rates of assemblage A in G...
  37. Song Y, Li W, Liu H, Zhong Z, Luo Y, Wei Y, et al. First report of Giardia duodenalis and Enterocytozoon bieneusi in forest musk deer (Moschus berezovskii) in China. Parasit Vectors. 2018;11:204 pubmed publisher
    ..One sample each was found to be positive based on the glutamate dehydrogenase (gdh) and triosephosphate isomerase (tpi) gene, respectively. Thirty-eight (17.04%) faecal samples were found to be E...
  38. Rajpal A, Dube S, Carvalho F, Simoes A, Figueiredo A, Basu A, et al. Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes. Am J Physiol Endocrinol Metab. 2013;305:E465-74 pubmed publisher
    ..0 and not different at baseline and clamp, indicating equivalent TA. To determine whether incomplete triose phosphate isomerase (TPI) exchange contributed to asymmetric ¹³C3/¹³C4, [U-¹³C]glycerol was infused in lieu of [1-¹³..
  39. Takahashi K, Kohno H. Different Polar Metabolites and Protein Profiles between High- and Low-Quality Japanese Ginjo Sake. PLoS ONE. 2016;11:e0150524 pubmed publisher
    ..Furthermore, protein analysis displayed that a diversity of protein components and yeast protein (triosephosphate isomerase, TPI) leakage was linked to the overall metabolite intensity in ginjo sake...
  40. Moghieb A, Bramlett H, Das J, Yang Z, Selig T, Yost R, et al. Differential Neuroproteomic and Systems Biology Analysis of Spinal Cord Injury. Mol Cell Proteomics. 2016;15:2379-95 pubmed publisher
    ..PEA15 (Phosphoprotein enriched in astrocytes 15), GOT2 (Glutamic-oxaloacetic transaminase 2), and TPI-1 (Triosephosphate isomerase 1), data are available via ProteomeXchange with identifier PXD003473...
  41. Mota J, Fonseca L, Braghiroli M, Hoff P. Review on TAS-102 development and its use for metastatic colorectal cancer. Crit Rev Oncol Hematol. 2016;104:91-7 pubmed publisher
    TAS-102 is the combination of trifluridine (TFT) with tipiracil (TPI) in a 1:0.5 molar ratio. TFT is a fluoropyrimidine that retains cytotoxic activity in 5-fluorouracil resistant cell lines...
  42. Medina Plaza C, de Saja J, Fernández Escudero J, Barajas E, Medrano G, Rodriguez Mendez M. Array of biosensors for discrimination of grapes according to grape variety, vintage and ripeness. Anal Chim Acta. 2016;947:16-22 pubmed publisher
    ..provided by the array of biosensors and classical parameters directly related to phenols (total polyphenol index, TPI) and sugar concentration (degree Brix) measured by chemical methods with correlation coefficients close to 1 and ..
  43. Markl D, Yassin S, Wilson D, Goodwin D, Anderson A, Zeitler J. Mathematical modelling of liquid transport in swelling pharmaceutical immediate release tablets. Int J Pharm. 2017;526:1-10 pubmed publisher
    ..Here we compare liquid ingress and swelling data obtained using terahertz pulsed imaging (TPI) to a set of mathematical models...
  44. Korasa K, Vrecer F. Overview of PAT process analysers applicable in monitoring of film coating unit operations for manufacturing of solid oral dosage forms. Eur J Pharm Sci. 2018;111:278-292 pubmed publisher
    ..techniques, which have made a significant breakthrough in recent years, are discussed (terahertz pulsed imaging (TPI), chord length distribution (CLD) analysis, and image analysis)...
  45. Novikova A, Markl D, Zeitler J, Rades T, Leopold C. A non-destructive method for quality control of the pellet distribution within a MUPS tablet by terahertz pulsed imaging. Eur J Pharm Sci. 2018;111:549-555 pubmed publisher
    Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets...
  46. Ganguly S, Mahanty A, Mitra T, Mohanty S, Das B, Mohanty B. Nutrigenomic studies on hilsa to evaluate flesh quality attributes and genes associated with fatty acid metabolism from the rivers Hooghly and Padma. Food Res Int. 2018;103:21-29 pubmed publisher
    ..Comparative gene expression profiling of flesh quality genes (actin, GAPDH, LDH, TPI) showed similar levels of expression in hilsa from both the rivers (P<0.05)...
  47. Li F, Wang H, Zhang Z, Li J, Wang C, Zhao J, et al. Prevalence and molecular characterization of Cryptosporidium spp. and Giardia duodenalis in dairy cattle in Beijing, China. Vet Parasitol. 2016;219:61-5 pubmed publisher
    ..Nine G. duodenalis isolates were analyzed by sequencing the triosephosphate isomerase (tpi) gene, and only G. duodenalis assemblage E was identified. Therefore, the predominance of C...
  48. Babaei Z, Malihi N, Zia Ali N, Sharifi I, Mohammadi M, Kagnoff M, et al. Adaptive immune response in symptomatic and asymptomatic enteric protozoal infection: evidence for a determining role of parasite genetic heterogeneity in host immunity to human giardiasis. Microbes Infect. 2016;18:687-695 pubmed publisher
    ..Using a semi-nested PCR method, clinical isolates were genetically characterized based on the gdh and tpi loci, and the phylogenetic trees were constructed...
  49. Applebaum M, Jha A, Kao C, Hernandez K, DeWane G, Salwen H, et al. Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients. Oncotarget. 2016;7:76816-76826 pubmed publisher
    ..and neuroblastoma derived cell lines, we identified nine genes (SLCO4A1, ENO1, HK2, PGK1, MTFP1, HILPDA, VKORC1, TPI1, and HIST1H1C) that are up-regulated in hypoxia and whose expression levels are correlated with poor patient ..
  50. Jin K, Li L, Sun X, Xu Q, Song S, Shen Y, et al. Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway. Appl Microbiol Biotechnol. 2017;101:4201-4213 pubmed publisher
    ..Our proteomic data showed that triosephosphate isomerase (TPI) and 6-phosphogluconolactonase (PGLS), which participate in glycolysis and the PPP, respectively, ..
  51. Novikova A, Carstensen J, Zeitler J, Rades T, Leopold C. Multispectral UV Imaging for Determination of the Tablet Coating Thickness. J Pharm Sci. 2017;106:1560-1569 pubmed publisher
    ..tablet and the corresponding coating thickness and its distribution measured by terahertz pulsed imaging (TPI). Three different tablet formulations were investigated, 2 of which contained UV-active tablet cores...
  52. Ramo A, del Cacho E, Sanchez Acedo C, Quilez J. Occurrence and genetic diversity of Cryptosporidium and Giardia in urban wastewater treatment plants in north-eastern Spain. Sci Total Environ. 2017;598:628-638 pubmed publisher
    ..molecular characterization of Cryptosporidium oocysts and Giardia cysts were attempted at the SSU rRNA/GP60 and bg/tpi loci, respectively. G...
  53. Faria C, Zanini G, Dias G, da Silva S, Sousa M. New multilocus genotypes of Giardia lamblia human isolates. Infect Genet Evol. 2017;54:128-137 pubmed publisher
    ..assemblages and subtypes were determined via multilocus sequence typing (MLST) using β-giardin, triose phosphate isomerase and glutamate dehydrogenase gene loci...
  54. van Klaveren D, Steyerberg E, Serruys P, Kent D. The proposed 'concordance-statistic for benefit' provided a useful metric when modeling heterogeneous treatment effects. J Clin Epidemiol. 2018;94:59-68 pubmed publisher
    ..725 vs. 0.719). However, for the simplified stroke-thrombolytic predictive instrument (TPI) vs. the original stroke-TPI, the c-for-benefit (0.584 vs. 0.578) was similar...
  55. Zumbar C, Usubalieva A, King P, Li X, Mifsud C, Dalton H, et al. The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells. J Neurooncol. 2018;137:481-492 pubmed publisher
    ..Unlike current clinically used taxane drugs, the novel taxane TPI 287 penetrates the CNS...
  56. Grüning N, Du D, Keller M, Luisi B, Ralser M. Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis. Open Biol. 2014;4:130232 pubmed publisher
    The inhibition of triosephosphate isomerase (TPI) in glycolysis by the pyruvate kinase (PK) substrate phosphoenolpyruvate (PEP) results in a newly discovered feedback loop that counters oxidative stress in cancer and actively respiring ..
  57. Wegayehu T, Karim M, Erko B, Zhang L, Tilahun G. Multilocus genotyping of Giardia duodenalis isolates from calves in Oromia Special Zone, Central Ethiopia. Infect Genet Evol. 2016;43:281-8 pubmed publisher
    ..samples were collected and screened using microscopy and PCR targeting the small-subunit (ssu) rRNA, triose phosphate isomerase (tpi), ?-giardin (bg) and glutamate dehydrogenase (gdh) genes...
  58. Zhou H, Lian L, Yan S, Song W. Insights into the photo-induced formation of reactive intermediates from effluent organic matter: The role of chemical constituents. Water Res. 2017;112:120-128 pubmed publisher
    ..EfOM was separated into hydrophobic (HPO), transphilic (TPI), and hydrophilic (HPI) components...
  59. Wang Y, Qiu D, Li M, Liu Y, Chen H, Li H. A new "on-off-on" fluorescent probe containing triarylimidazole chromophore to sequentially detect copper and sulfide ions. Spectrochim Acta A Mol Biomol Spectrosc. 2017;185:256-262 pubmed publisher
    A novel compound TPI-H containing triphenylimidazole chromophore is synthesized and employed as fluorescent probe for sequential detection of Cu2+ and S2-...
  60. Prudhon J, Caton J, Aslanian T, Verdier R. How is patella height modified after total knee arthroplasty?. Int Orthop. 2018;42:311-316 pubmed publisher
    ..In TKA, patella assessment in sagittal plane is as important as frontal or horizontal planes. True patella infera (TPI) is mostly due to patella tendon shortening measured by oCD...
  61. O Sullivan C, Davarpanah N, Abraham J, Bates S. Current challenges in the management of breast cancer brain metastases. Semin Oncol. 2017;44:85-100 pubmed publisher
    ..cyclin-dependent kinase 4/6 (CDK4/6) inhibitors (palbociclib, abemaciclib), and taxane derivatives (eg, ANG1005 and TPI-287)...
  62. Baba T, Kokuryo T, Yamaguchi J, Yokoyama Y, Uehara K, Ebata T, et al. Pre-exposure to Fluorouracil Increased Trifluridine Incorporation and Enhanced its Anti-tumor Effect for Colorectal Cancer. Anticancer Res. 2018;38:1427-1434 pubmed
    Trifluridine/tipiracil (FTD/TPI) is used for metastatic colorectal cancer, that is refractory to 5-fluorouracil (5-FU)-based therapies...
  63. Sasajima T, Watanabe H, Sato S, Sato Y, Ohira H. Anti-triosephosphate isomerase antibodies in cerebrospinal fluid are associated with neuropsychiatric lupus. J Neuroimmunol. 2006;181:150-6 pubmed
    We detected anti-triosephosphate isomerase antibodies (anti-TPI) in cerebrospinal fluid (CSF) in 5 of 12 neuropsychiatric lupus patients (41.6%) by Western blotting...
  64. Manco L, Machado P, Lopes D, Nogueira F, Do Rosario V, Alonso P, et al. Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples. Am J Hum Biol. 2009;21:118-20 pubmed publisher
    Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5A-->G, -8G-->A and -24T-->G...
  65. Davison E, Pennington K, Hung C, Peng J, Rafiq R, Ostareck Lederer A, et al. Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function. Proteomics. 2009;9:4284-97 pubmed publisher
    ..MS revealed the identity of these proteins to be ACAT2, HNRNPK, HSPD1, PGK1, PRDX6, VCL, VIM, TPI1, and IMPDH2. The first seven of these were reduced in expression...
  66. Jiang H, Ma N, Shang Y, Zhou W, Chen T, Guan D, et al. Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2017;482:1048-1053 pubmed publisher
    Metabolic dysregulation is one of the most common and recognizable features of cancer. Triosephosphate isomerase 1 (TPI1), which catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde-3-phosphate (G3P) ..
  67. Markl D, Zeitler J, Rasch C, Michaelsen M, Mullertz A, Rantanen J, et al. Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging. Pharm Res. 2017;34:1037-1052 pubmed publisher
    ..of 3D printed solid dosage forms using X-ray computed microtomography (X?CT) and terahertz pulsed imaging (TPI). Printing was performed with either polyvinyl alcohol (PVA) or polylactic acid (PLA)...
  68. Mondal P, Das G, Khan J, Pradhan K, Ghosh S. Crafting of Neuroprotective Octapeptide from Taxol-binding Pocket of ?-Tubulin. ACS Chem Neurosci. 2017;: pubmed publisher
    ..However, other microtubule-targeting agents such as epothilone D (BMS-241027) and TPI-287 (abeotaxane) and NAP peptide (davunetide) have entered in AD clinical programme...
  69. Mande S, Mainfroid V, Kalk K, Goraj K, Martial J, Hol W. Crystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme. Protein Sci. 1994;3:810-21 pubmed
    The crystal structure of recombinant human triosephosphate isomerase (hTIM) has been determined complexed with the transition-state analogue 2-phosphoglycolate at a resolution of 2.8 A. After refinement, the R-factor is 16...
  70. Ansari Lari M, Muzny D, Lu J, Lu F, Lilley C, Spanos S, et al. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res. 1996;6:314-26 pubmed
    ..Six genes, including CD4, triosephosphate isomerase, B3 subunit of G proteins (GNB3), and ubiquitin isopeptidase T (ISOT), with known functions, and two new ..
  71. Ationu A, Humphries A. The feasibility of replacement therapy for inherited disorder of glycolysis: triosephosphate isomerase deficiency (review). Int J Mol Med. 1998;2:701-4 pubmed
    b>Triosephosphate isomerase (TPI, EC 5.3.1.1) is an ubiquitously expressed enzyme that catalyses the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate in the energy-generating glycolytic pathway...
  72. Xiang Y, Sekine T, Nakamura H, Imajoh Ohmi S, Fukuda H, Nishioka K, et al. Proteomic surveillance of autoimmunity in osteoarthritis: identification of triosephosphate isomerase as an autoantigen in patients with osteoarthritis. Arthritis Rheum. 2004;50:1511-21 pubmed
    ..One of these proteins was identified as triosephosphate isomerase (TPI). IgG-type anti-TPI autoantibodies were detected in 24.7% of the serum samples and 24...
  73. Watanabe H, Seino T, Sato Y. Antibodies to triosephosphate isomerase in patients with neuropsychiatric lupus. Biochem Biophys Res Commun. 2004;321:949-53 pubmed
    ..A 29-kDa protein band detected in NP lupus sera was identified as triosephosphate isomerase (TPI)...
  74. Naryzhny S, Lee H. Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer. FEBS Lett. 2010;584:4292-8 pubmed publisher
    ..Surprisingly, PCNA is also associated with six glycolytic enzymes that are involved in the regulation of steps 4-9 in the glycolysis pathway. ..
  75. De Moor W, van Marwijk J, Wilhelmi B, Whiteley C. Interaction of Silver Nanoparticles with Triosephosphate Isomerase from Human and Malarial Parasite (Plasmodium falciparum): A Comparative Study. J Biomed Nanotechnol. 2015;11:1071-9 pubmed
    Recombinant triosephosphate isomerase from Plasmodium falciparum (PfTIM) and humans (hTIM) were expressed, purified and characterised. High specific activity (1207 U x mg(-1)) with a fold purification of -1...
  76. Hong J, Park J, Jeon D, Yoon W, Park J. Extracorporeal Shock Wave Therapy Versus Trigger Point Injection in the Treatment of Myofascial Pain Syndrome in the Quadratus Lumborum. Ann Rehabil Med. 2017;41:582-588 pubmed publisher
    To compare the effectiveness of extracorporeal shock wave therapy (ESWT) and trigger point injection (TPI) for the treatment of myofascial pain syndrome in the quadratus lumborum.
  77. Sarmento F, Tanaka H, Cordeiro E, Suzuki K. Effectiveness of Biofield Therapy for Patients Diagnosed With Fibromyalgia. Altern Ther Health Med. 2017;: pubmed
    ..included the Beck depression inventory (BDI), the fibromyalgia impact questionnaire (FIQ), the tender point index (TPI), and changes in the dosage of prescribed medication...
  78. Kaise A, Ohta K, Shirata C, Endo Y. Design and synthesis of p-carborane-containing sulfamates as multitarget anti-breast cancer agents. Bioorg Med Chem. 2017;25:6417-6426 pubmed publisher
    ..8??M), and tubulin-polymerization-inhibitory (TPI) activity...
  79. Lu H, Yuan P, Gracy R. Primary structure of human triosephosphate isomerase. J Biol Chem. 1984;259:11958-68 pubmed
    Human placental triosephosphate isomerase was isolated by an improved procedure and recovered with the highest specific activity ever reported...
  80. Wang X, Lu Y, Yang J, Shi Y, Lan M, Liu Z, et al. Identification of triosephosphate isomerase as an anti-drug resistance agent in human gastric cancer cells using functional proteomic analysis. J Cancer Res Clin Oncol. 2008;134:995-1003 pubmed publisher
    ..b>Triosephosphate isomerase (TPI), a glycolytic pathway enzyme, was identified as a downregulated protein in SGC7901/VCR cells...
  81. De la Mora De la Mora I, Torres Larios A, Mendoza Hernandez G, Enriquez Flores S, Castillo Villanueva A, Méndez S, et al. The E104D mutation increases the susceptibility of human triosephosphate isomerase to proteolysis. Asymmetric cleavage of the two monomers of the homodimeric enzyme. Biochim Biophys Acta. 2013;1834:2702-11 pubmed publisher
    The deficiency of human triosephosphate isomerase (HsTIM) generates neurological alterations, cardiomyopathy and premature death. The mutation E104D is the most frequent cause of the disease...
  82. Yassin S, Goodwin D, Anderson A, Sibik J, Ian Wilson D, Gladden L, et al. The Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1: Influence of Temperature, Porosity and Superdisintegrants. J Pharm Sci. 2015;104:3440-3450 pubmed publisher
    ..of pure microcrystalline cellulose (MCC) and in mixture with croscarmellose sodium using terahertz pulsed imaging (TPI)...
  83. Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Dadduzio V, et al. Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer. Eur J Cancer. 2017;86:197-206 pubmed publisher
    ..cytotoxic component of the metastatic colorectal cancer (mCRC) drug TAS-102, and thymidine phosphorylase inhibitor (TPI) inhibits the rapid degradation of FTD...
  84. Dillon F, Daniela Tejedor M, Ilina N, Chludil H, Mithofer A, Pagano E, et al. Solar UV-B radiation and ethylene play a key role in modulating effective defenses against Anticarsia gemmatalis larvae in field-grown soybean. Plant Cell Environ. 2017;: pubmed publisher
    ..in plants grown under solar UV-B radiation and was positively correlated with malonyl genistin concentration, TPI activity and expression of IFS2 and the pathogenesis protein PR2, while was negatively correlated with leaf ..
  85. Boyer T, Maquat L. Minimal sequence and factor requirements for the initiation of transcription from an atypical, TATATAA box-containing housekeeping promoter. J Biol Chem. 1990;265:20524-32 pubmed
    ..Utilizing a transient cotransfection protocol, we have found that efficient transactivation of triosephosphate isomerase (TPI) gene transcription by the immediate early proteins of adenovirus and pseudorabies virus is ..
  86. Humphries A, Ationu A, Wild B, Layton D. The consequence of nucleotide substitutions in the triosephosphate isomerase (TPI) gene promoter. Blood Cells Mol Dis. 1999;25:210-7 pubmed
    ..5A-->G, -8-->GA within the cap proximal element (CPE), and -24T-->G within the TATA box of the triosephosphate isomerase (TPI) gene promoter have been identified in populations with a wide geographical distribution...
  87. Tompkins V, Hagen J, Zediak V, Quelle D. Identification of novel ARF binding proteins by two-hybrid screening. Cell Cycle. 2006;5:641-6 pubmed
    ..The potential physiological roles of these novel ARF binding proteins in regulating ARF signaling are discussed. ..
  88. Lin H, Dong Y, Markl D, Williams B, Zheng Y, Shen Y, et al. Measurement of the Intertablet Coating Uniformity of a Pharmaceutical Pan Coating Process With Combined Terahertz and Optical Coherence Tomography In-Line Sensing. J Pharm Sci. 2017;106:1075-1084 pubmed publisher
    ..thickness measurements acquired simultaneously using 2 independent sensing modalities: terahertz pulsed imaging (TPI) and optical coherence tomography (OCT)...
  89. Delgado González M, Sánchez Guillén M, García Moreno M, Rodríguez Dodero M, García Barroso C, Guillén Sánchez D. Study of a laboratory-scaled new method for the accelerated continuous ageing of wine spirits by applying ultrasound energy. Ultrason Sonochem. 2017;36:226-235 pubmed publisher
    ..large pulses is related with the improvement of two important ageing markers: the intensity of the colour and the TPI. As a last experiment, we applied this ageing method to five varietal spirits...
  90. Ayodele B, Mirams M, Pagel C, Mackie E. The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation. Bone Rep. 2017;7:98-107 pubmed publisher
    ..i>DDX5, GNB1, PIP4K2A, RAP1B, RPS7, SRSF3, SUB1, TMSB4, TPI1 and WSB2) were found to be more highly expressed in the zone of hypertrophic chondrocytes than in the ..
  91. Zhao S, Li K, Jin Y, Lin J. Synthesis and biological evaluation of novel 1-(aryl-aldehyde-oxime)uracil derivatives as a new class of thymidine phosphorylase inhibitors. Eur J Med Chem. 2018;144:41-51 pubmed publisher
    ..7 to 39.9 μM) showed a good thymidine phosphorylase inhibition when compared to the standard 7DX and TPI. The most biologically active compound 8l was demonstrated to be a competition mode of enzyme inhibition...
  92. Ansari Lari M, Shen Y, Muzny D, Lee W, Gibbs R. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. Genome Res. 1997;7:268-80 pubmed
    ..The high number of genes with diverse functions and complex transcriptional patterns make this region ideal for addressing challenges of gene discovery and genomic characterization amenable to large-scale sequence analysis. ..