TPI1

Summary

Gene Symbol: TPI1
Description: triosephosphate isomerase 1
Alias: HEL-S-49, TIM, TPI, TPID, triosephosphate isomerase, epididymis secretory protein Li 49, triose-phosphate isomerase
Species: human
Products:     TPI1

Top Publications

  1. Olah J, Orosz F, Keseru G, Kovári Z, Kovacs J, Hollan S, et al. Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease. Biochem Soc Trans. 2002;30:30-8 pubmed
    ..Of the several well-established glycolytic enzyme deficiencies, triosephosphate isomerase (TPI) deficiency is the only one in which haemolytic anaemia is coupled with progressive, severe ..
  2. Jung J, Yoon T, Choi E, Lee K. Interaction of cofilin with triose-phosphate isomerase contributes glycolytic fuel for Na,K-ATPase via Rho-mediated signaling pathway. J Biol Chem. 2002;277:48931-7 pubmed
    ..by the p160 Rho-associated kinase inhibitor Y-27632, suggesting that the phosphorylated form of cofilin bound to TPI interacts with Na,K-ATPase...
  3. Daar I, Artymiuk P, Phillips D, Maquat L. Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme. Proc Natl Acad Sci U S A. 1986;83:7903-7 pubmed
    Triose-phosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketol-isomerase, EC 5.3.1.1) deficiency is a recessive disorder that results in hemolytic anemia and neuromuscular dysfunction...
  4. Brown J, Daar I, Krug J, Maquat L. Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. Mol Cell Biol. 1985;5:1694-706 pubmed
    The functional gene and three intronless pseudogenes for human triosephosphate isomerase were isolated from a recombinant DNA library and characterized in detail. The functional gene spans 3.5 kilobase pairs and is split into seven exons...
  5. Orosz F, Olah J, Alvarez M, Keseru G, Szabo B, Wagner G, et al. Distinct behavior of mutant triosephosphate isomerase in hemolysate and in isolated form: molecular basis of enzyme deficiency. Blood. 2001;98:3106-12 pubmed
    In a Hungarian family with severe decrease in triosephosphate isomerase (TPI) activity, 2 germ line-identical but phenotypically differing compound heterozygote brothers inherited 2 independent (Phe240Leu and Glu145stop codon) mutations...
  6. Chang M, Artymiuk P, Wu X, Hollan S, Lammi A, Maquat L. Human triosephosphate isomerase deficiency resulting from mutation of Phe-240. Am J Hum Genet. 1993;52:1260-9 pubmed
    b>Triosephosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketolisomerase [E.C.5.3.1.1]) deficiency is an autosomal recessive disorder that typically results in chronic, nonspherocytic hemolytic anemia and in neuromuscular impairment...
  7. Watanabe M, Zingg B, Mohrenweiser H. Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus. Am J Hum Genet. 1996;58:308-16 pubmed
    Individuals with 50% of expected triosephosphate isomerase (TPI) enzyme activity have been previously identified in families during the screening of approximately 2,000 newborn children for quantitative variation in activity of 12 ..
  8. Arya R, Lalloz M, Bellingham A, Layton D. Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency. Hum Mutat. 1997;10:290-4 pubmed
    b>Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disorder of glycolysis characterized by multisystem disease and lethality in early childhood...
  9. Ralser M, Nebel A, Kleindorp R, Krobitsch S, Lehrach H, Schreiber S, et al. Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans. BMC Genet. 2008;9:38 pubmed publisher
    b>Triosephosphate isomerase (TPI) is a central and conserved glycolytic enzyme. In humans, TPI is encoded by a single gene on 12p13, and associated with a rare genetic disorder, TPI deficiency...
  10. Perry B, Mohrenweiser H. Human triosephosphate isomerase: substitution of Arg for Gly at position 122 in a thermolabile electromorph variant, TPI-Manchester. Hum Genet. 1992;88:634-8 pubmed
    ..transition causing a replacement of Gly 122 with Arg in an electrophoretic mobility variant of human triosephosphate isomerase, TPI-Manchester...

Detail Information

Publications62

  1. Olah J, Orosz F, Keseru G, Kovári Z, Kovacs J, Hollan S, et al. Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease. Biochem Soc Trans. 2002;30:30-8 pubmed
    ..Of the several well-established glycolytic enzyme deficiencies, triosephosphate isomerase (TPI) deficiency is the only one in which haemolytic anaemia is coupled with progressive, severe ..
  2. Jung J, Yoon T, Choi E, Lee K. Interaction of cofilin with triose-phosphate isomerase contributes glycolytic fuel for Na,K-ATPase via Rho-mediated signaling pathway. J Biol Chem. 2002;277:48931-7 pubmed
    ..by the p160 Rho-associated kinase inhibitor Y-27632, suggesting that the phosphorylated form of cofilin bound to TPI interacts with Na,K-ATPase...
  3. Daar I, Artymiuk P, Phillips D, Maquat L. Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme. Proc Natl Acad Sci U S A. 1986;83:7903-7 pubmed
    Triose-phosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketol-isomerase, EC 5.3.1.1) deficiency is a recessive disorder that results in hemolytic anemia and neuromuscular dysfunction...
  4. Brown J, Daar I, Krug J, Maquat L. Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. Mol Cell Biol. 1985;5:1694-706 pubmed
    The functional gene and three intronless pseudogenes for human triosephosphate isomerase were isolated from a recombinant DNA library and characterized in detail. The functional gene spans 3.5 kilobase pairs and is split into seven exons...
  5. Orosz F, Olah J, Alvarez M, Keseru G, Szabo B, Wagner G, et al. Distinct behavior of mutant triosephosphate isomerase in hemolysate and in isolated form: molecular basis of enzyme deficiency. Blood. 2001;98:3106-12 pubmed
    In a Hungarian family with severe decrease in triosephosphate isomerase (TPI) activity, 2 germ line-identical but phenotypically differing compound heterozygote brothers inherited 2 independent (Phe240Leu and Glu145stop codon) mutations...
  6. Chang M, Artymiuk P, Wu X, Hollan S, Lammi A, Maquat L. Human triosephosphate isomerase deficiency resulting from mutation of Phe-240. Am J Hum Genet. 1993;52:1260-9 pubmed
    b>Triosephosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketolisomerase [E.C.5.3.1.1]) deficiency is an autosomal recessive disorder that typically results in chronic, nonspherocytic hemolytic anemia and in neuromuscular impairment...
  7. Watanabe M, Zingg B, Mohrenweiser H. Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus. Am J Hum Genet. 1996;58:308-16 pubmed
    Individuals with 50% of expected triosephosphate isomerase (TPI) enzyme activity have been previously identified in families during the screening of approximately 2,000 newborn children for quantitative variation in activity of 12 ..
  8. Arya R, Lalloz M, Bellingham A, Layton D. Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency. Hum Mutat. 1997;10:290-4 pubmed
    b>Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disorder of glycolysis characterized by multisystem disease and lethality in early childhood...
  9. Ralser M, Nebel A, Kleindorp R, Krobitsch S, Lehrach H, Schreiber S, et al. Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans. BMC Genet. 2008;9:38 pubmed publisher
    b>Triosephosphate isomerase (TPI) is a central and conserved glycolytic enzyme. In humans, TPI is encoded by a single gene on 12p13, and associated with a rare genetic disorder, TPI deficiency...
  10. Perry B, Mohrenweiser H. Human triosephosphate isomerase: substitution of Arg for Gly at position 122 in a thermolabile electromorph variant, TPI-Manchester. Hum Genet. 1992;88:634-8 pubmed
    ..transition causing a replacement of Gly 122 with Arg in an electrophoretic mobility variant of human triosephosphate isomerase, TPI-Manchester...
  11. Olah J, Orosz F, Puskas L, Hackler L, Horanyi M, Polgar L, et al. Triosephosphate isomerase deficiency: consequences of an inherited mutation at mRNA, protein and metabolic levels. Biochem J. 2005;392:675-83 pubmed
    b>Triosephosphate isomerase (TPI) deficiency is a unique glycolytic enzymopathy coupled with neurodegeneration...
  12. Orosz F, Wagner G, Liliom K, Kovacs J, Baróti K, Horanyi M, et al. Enhanced association of mutant triosephosphate isomerase to red cell membranes and to brain microtubules. Proc Natl Acad Sci U S A. 2000;97:1026-31 pubmed
    In a Hungarian family with triosephosphate isomerase (TPI; D-glyceraldehyde-3-phosphate keto-isomerase, EC 5.3.1...
  13. Ralser M, Heeren G, Breitenbach M, Lehrach H, Krobitsch S. Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes. PLoS ONE. 2006;1:e30 pubmed
    b>Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disorder caused by various mutations in the gene encoding the key glycolytic enzyme TPI...
  14. Manco L, Machado P, Lopes D, Nogueira F, Do Rosario V, Alonso P, et al. Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples. Am J Hum Biol. 2009;21:118-20 pubmed publisher
    Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5A-->G, -8G-->A and -24T-->G...
  15. Davison E, Pennington K, Hung C, Peng J, Rafiq R, Ostareck Lederer A, et al. Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function. Proteomics. 2009;9:4284-97 pubmed publisher
    ..MS revealed the identity of these proteins to be ACAT2, HNRNPK, HSPD1, PGK1, PRDX6, VCL, VIM, TPI1, and IMPDH2. The first seven of these were reduced in expression...
  16. Sasajima T, Watanabe H, Sato S, Sato Y, Ohira H. Anti-triosephosphate isomerase antibodies in cerebrospinal fluid are associated with neuropsychiatric lupus. J Neuroimmunol. 2006;181:150-6 pubmed
    We detected anti-triosephosphate isomerase antibodies (anti-TPI) in cerebrospinal fluid (CSF) in 5 of 12 neuropsychiatric lupus patients (41.6%) by Western blotting...
  17. Markl D, Zeitler J, Rasch C, Michaelsen M, Mullertz A, Rantanen J, et al. Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging. Pharm Res. 2017;34:1037-1052 pubmed publisher
    ..of 3D printed solid dosage forms using X-ray computed microtomography (X?CT) and terahertz pulsed imaging (TPI). Printing was performed with either polyvinyl alcohol (PVA) or polylactic acid (PLA)...
  18. Mondal P, Das G, Khan J, Pradhan K, Ghosh S. Crafting of Neuroprotective Octapeptide from Taxol-binding Pocket of ?-Tubulin. ACS Chem Neurosci. 2017;: pubmed publisher
    ..However, other microtubule-targeting agents such as epothilone D (BMS-241027) and TPI-287 (abeotaxane) and NAP peptide (davunetide) have entered in AD clinical programme...
  19. Jiang H, Ma N, Shang Y, Zhou W, Chen T, Guan D, et al. Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2017;482:1048-1053 pubmed publisher
    Metabolic dysregulation is one of the most common and recognizable features of cancer. Triosephosphate isomerase 1 (TPI1), which catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde-3-phosphate (G3P) ..
  20. Naryzhny S, Lee H. Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer. FEBS Lett. 2010;584:4292-8 pubmed publisher
    ..Surprisingly, PCNA is also associated with six glycolytic enzymes that are involved in the regulation of steps 4-9 in the glycolysis pathway. ..
  21. Hong J, Park J, Jeon D, Yoon W, Park J. Extracorporeal Shock Wave Therapy Versus Trigger Point Injection in the Treatment of Myofascial Pain Syndrome in the Quadratus Lumborum. Ann Rehabil Med. 2017;41:582-588 pubmed publisher
    To compare the effectiveness of extracorporeal shock wave therapy (ESWT) and trigger point injection (TPI) for the treatment of myofascial pain syndrome in the quadratus lumborum.
  22. De Moor W, van Marwijk J, Wilhelmi B, Whiteley C. Interaction of Silver Nanoparticles with Triosephosphate Isomerase from Human and Malarial Parasite (Plasmodium falciparum): A Comparative Study. J Biomed Nanotechnol. 2015;11:1071-9 pubmed
    Recombinant triosephosphate isomerase from Plasmodium falciparum (PfTIM) and humans (hTIM) were expressed, purified and characterised. High specific activity (1207 U x mg(-1)) with a fold purification of -1...
  23. Xiang Y, Sekine T, Nakamura H, Imajoh Ohmi S, Fukuda H, Nishioka K, et al. Proteomic surveillance of autoimmunity in osteoarthritis: identification of triosephosphate isomerase as an autoantigen in patients with osteoarthritis. Arthritis Rheum. 2004;50:1511-21 pubmed
    ..One of these proteins was identified as triosephosphate isomerase (TPI). IgG-type anti-TPI autoantibodies were detected in 24.7% of the serum samples and 24...
  24. Mande S, Mainfroid V, Kalk K, Goraj K, Martial J, Hol W. Crystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme. Protein Sci. 1994;3:810-21 pubmed
    The crystal structure of recombinant human triosephosphate isomerase (hTIM) has been determined complexed with the transition-state analogue 2-phosphoglycolate at a resolution of 2.8 A. After refinement, the R-factor is 16...
  25. Ansari Lari M, Muzny D, Lu J, Lu F, Lilley C, Spanos S, et al. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res. 1996;6:314-26 pubmed
    ..Six genes, including CD4, triosephosphate isomerase, B3 subunit of G proteins (GNB3), and ubiquitin isopeptidase T (ISOT), with known functions, and two new ..
  26. Kaise A, Ohta K, Shirata C, Endo Y. Design and synthesis of p-carborane-containing sulfamates as multitarget anti-breast cancer agents. Bioorg Med Chem. 2017;25:6417-6426 pubmed publisher
    ..8??M), and tubulin-polymerization-inhibitory (TPI) activity...
  27. Ationu A, Humphries A. The feasibility of replacement therapy for inherited disorder of glycolysis: triosephosphate isomerase deficiency (review). Int J Mol Med. 1998;2:701-4 pubmed
    b>Triosephosphate isomerase (TPI, EC 5.3.1.1) is an ubiquitously expressed enzyme that catalyses the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate in the energy-generating glycolytic pathway...
  28. Sarmento F, Tanaka H, Cordeiro E, Suzuki K. Effectiveness of Biofield Therapy for Patients Diagnosed With Fibromyalgia. Altern Ther Health Med. 2017;: pubmed
    ..included the Beck depression inventory (BDI), the fibromyalgia impact questionnaire (FIQ), the tender point index (TPI), and changes in the dosage of prescribed medication...
  29. Watanabe H, Seino T, Sato Y. Antibodies to triosephosphate isomerase in patients with neuropsychiatric lupus. Biochem Biophys Res Commun. 2004;321:949-53 pubmed
    ..A 29-kDa protein band detected in NP lupus sera was identified as triosephosphate isomerase (TPI)...
  30. Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Dadduzio V, et al. Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer. Eur J Cancer. 2017;86:197-206 pubmed publisher
    ..cytotoxic component of the metastatic colorectal cancer (mCRC) drug TAS-102, and thymidine phosphorylase inhibitor (TPI) inhibits the rapid degradation of FTD...
  31. Wang X, Lu Y, Yang J, Shi Y, Lan M, Liu Z, et al. Identification of triosephosphate isomerase as an anti-drug resistance agent in human gastric cancer cells using functional proteomic analysis. J Cancer Res Clin Oncol. 2008;134:995-1003 pubmed publisher
    ..b>Triosephosphate isomerase (TPI), a glycolytic pathway enzyme, was identified as a downregulated protein in SGC7901/VCR cells...
  32. Yassin S, Goodwin D, Anderson A, Sibik J, Ian Wilson D, Gladden L, et al. The Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1: Influence of Temperature, Porosity and Superdisintegrants. J Pharm Sci. 2015;104:3440-3450 pubmed publisher
    ..of pure microcrystalline cellulose (MCC) and in mixture with croscarmellose sodium using terahertz pulsed imaging (TPI)...
  33. Lu H, Yuan P, Gracy R. Primary structure of human triosephosphate isomerase. J Biol Chem. 1984;259:11958-68 pubmed
    Human placental triosephosphate isomerase was isolated by an improved procedure and recovered with the highest specific activity ever reported...
  34. Dillon F, Daniela Tejedor M, Ilina N, Chludil H, Mithofer A, Pagano E, et al. Solar UV-B radiation and ethylene play a key role in modulating effective defenses against Anticarsia gemmatalis larvae in field-grown soybean. Plant Cell Environ. 2017;: pubmed publisher
    ..in plants grown under solar UV-B radiation and was positively correlated with malonyl genistin concentration, TPI activity and expression of IFS2 and the pathogenesis protein PR2, while was negatively correlated with leaf ..
  35. De la Mora De la Mora I, Torres Larios A, Mendoza Hernandez G, Enriquez Flores S, Castillo Villanueva A, Méndez S, et al. The E104D mutation increases the susceptibility of human triosephosphate isomerase to proteolysis. Asymmetric cleavage of the two monomers of the homodimeric enzyme. Biochim Biophys Acta. 2013;1834:2702-11 pubmed publisher
    The deficiency of human triosephosphate isomerase (HsTIM) generates neurological alterations, cardiomyopathy and premature death. The mutation E104D is the most frequent cause of the disease...
  36. Ayodele B, Mirams M, Pagel C, Mackie E. The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation. Bone Rep. 2017;7:98-107 pubmed publisher
    ..i>DDX5, GNB1, PIP4K2A, RAP1B, RPS7, SRSF3, SUB1, TMSB4, TPI1 and WSB2) were found to be more highly expressed in the zone of hypertrophic chondrocytes than in the ..
  37. Nooshadokht M, Kalantari Khandani B, Sharifi I, Kamyabi H, Liyanage N, Lagenaur L, et al. Stool antigen immunodetection for diagnosis of Giardia duodenalis infection in human subjects with HIV and cancer. J Microbiol Methods. 2017;141:35-41 pubmed publisher
    ..Further multilocus molecular analyses using glutamate dehydrogenase (gdh) and triose phosphate isomerase (tpi) loci demonstrated that the AI genotype of G...
  38. Delgado González M, Sánchez Guillén M, García Moreno M, Rodríguez Dodero M, García Barroso C, Guillén Sánchez D. Study of a laboratory-scaled new method for the accelerated continuous ageing of wine spirits by applying ultrasound energy. Ultrason Sonochem. 2017;36:226-235 pubmed publisher
    ..large pulses is related with the improvement of two important ageing markers: the intensity of the colour and the TPI. As a last experiment, we applied this ageing method to five varietal spirits...
  39. Lin H, Dong Y, Markl D, Williams B, Zheng Y, Shen Y, et al. Measurement of the Intertablet Coating Uniformity of a Pharmaceutical Pan Coating Process With Combined Terahertz and Optical Coherence Tomography In-Line Sensing. J Pharm Sci. 2017;106:1075-1084 pubmed publisher
    ..thickness measurements acquired simultaneously using 2 independent sensing modalities: terahertz pulsed imaging (TPI) and optical coherence tomography (OCT)...
  40. Zhao S, Li K, Jin Y, Lin J. Synthesis and biological evaluation of novel 1-(aryl-aldehyde-oxime)uracil derivatives as a new class of thymidine phosphorylase inhibitors. Eur J Med Chem. 2017;144:41-51 pubmed publisher
    ..7 to 39.9 ?M) showed a good thymidine phosphorylase inhibition when compared to the standard 7DX and TPI. The most biologically active compound 8l was demonstrated to be a competition mode of enzyme inhibition...
  41. Tompkins V, Hagen J, Zediak V, Quelle D. Identification of novel ARF binding proteins by two-hybrid screening. Cell Cycle. 2006;5:641-6 pubmed
    ..The potential physiological roles of these novel ARF binding proteins in regulating ARF signaling are discussed. ..
  42. Boyer T, Maquat L. Minimal sequence and factor requirements for the initiation of transcription from an atypical, TATATAA box-containing housekeeping promoter. J Biol Chem. 1990;265:20524-32 pubmed
    ..Utilizing a transient cotransfection protocol, we have found that efficient transactivation of triosephosphate isomerase (TPI) gene transcription by the immediate early proteins of adenovirus and pseudorabies virus is ..
  43. Humphries A, Ationu A, Wild B, Layton D. The consequence of nucleotide substitutions in the triosephosphate isomerase (TPI) gene promoter. Blood Cells Mol Dis. 1999;25:210-7 pubmed
    ..5A-->G, -8-->GA within the cap proximal element (CPE), and -24T-->G within the TATA box of the triosephosphate isomerase (TPI) gene promoter have been identified in populations with a wide geographical distribution...
  44. Olivares Illana V, Riveros Rosas H, Cabrera N, Tuena de Gomez Puyou M, Perez Montfort R, Costas M, et al. A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease. Proteins. 2017;85:1190-1211 pubmed publisher
    b>Triosephosphate isomerase (TIM) is a ubiquitous enzyme, which appeared early in evolution...
  45. Hipkiss A. Energy metabolism and ageing regulation: metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction. Ageing Res Rev. 2011;10:498-502 pubmed publisher
    ..out up to 3 decades ago by Gracy and co-workers revealed that the activity of the glycolytic enzyme triosephosphate isomerase (TPI), which converts dihydroxyacetone phosphate (DHAP) to glyceraldehyde-3-phosphate (G3P), gradually ..
  46. Li R, Wang Z, Han P, He Y, Zhang X, Wang Y. Refreshing Rubbers as Customized Photothermal Conversion Materials through Post-Darkening Modeling Production. Chemistry. 2017;: pubmed publisher
    ..concept of post-darkening modeling production (p-DMP) by which the thermoplastic non-conjugated trans-polyisoprene (TPI) is refreshed into a photo-thermal conversion material with high light use efficiency...
  47. Ansari Lari M, Shen Y, Muzny D, Lee W, Gibbs R. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. Genome Res. 1997;7:268-80 pubmed
    ..The high number of genes with diverse functions and complex transcriptional patterns make this region ideal for addressing challenges of gene discovery and genomic characterization amenable to large-scale sequence analysis. ..
  48. Ji H, Reid G, Moritz R, Eddes J, Burgess A, Simpson R. A two-dimensional gel database of human colon carcinoma proteins. Electrophoresis. 1997;18:605-13 pubmed
    ..These data, and descriptions of the micro-techniques employed in this laboratory for identifying 2-DE resolved proteins can be accessed via the internet URL: http:(/)/www.ludwig.edu.au. ..
  49. Lai H, Huang C, Cai J, Ye J, She J, Zheng Y, et al. Simultaneous detection and characterization of toxigenic Clostridium difficile directly from clinical stool specimens. Front Med. 2017;: pubmed publisher
    ..PCR) coupled with capillary electrophoresis (mPCR-CE) targeting six Clostridium difficile genes, including tpi, tcdA, tcdB, cdtA, cdtB, and a deletion in tcdC for simultaneous detection and characterization of toxigenic C...
  50. Hollan S, Vecsei L, Magyar K. Adverse effects of dopamine potentiation by long-term treatment with selegiline. Mov Disord. 2004;19:107-9 pubmed
    A patient with triosephosphate isomerase (TPI) deficiency exhibited worsening of abnormal involuntary movements of the dystonic type and developed psychiatric symptoms while on selegiline...
  51. Lin H, Dong Y, Shen Y, Axel Zeitler J. Quantifying Pharmaceutical Film Coating with Optical Coherence Tomography and Terahertz Pulsed Imaging: An Evaluation. J Pharm Sci. 2015;104:3377-3385 pubmed publisher
    ..paper evaluates tablets with a range of film coating thickness measured using OCT and terahertz pulsed imaging (TPI) in an off-line setting...
  52. Fermo E, Bianchi P, Vercellati C, Rees D, Marcello A, Barcellini W, et al. Triose phosphate isomerase deficiency associated with two novel mutations in TPI gene. Eur J Haematol. 2010;85:170-3 pubmed publisher
    We report the clinical, haematological and molecular characteristics of two triose phosphate isomerase deficient patients affected by haemolytic anaemia and neuromuscular impairment...
  53. Jian X, Li N, Chen Q, Hua Q. Model-guided identification of novel gene amplification targets for improving succinate production in Escherichia coli NZN111. Integr Biol (Camb). 2017;9:830-835 pubmed publisher
    ..expression analysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), triosephosphate isomerase (TPI), and phosphoenolpyruvate carboxylase (PPC), encoded by gapA, pgk, tpiA, and ppc, respectively, ..
  54. Zhang Z, Jin W, Beckett J, Otto T, Moed B. A proteomic approach for identification and localization of the pericellular components of chondrocytes. Histochem Cell Biol. 2011;136:153-62 pubmed publisher
    ..Other identified PCM proteins included triosephosphate isomerase, transforming growth factor-? induced protein, peroxiredoxin-4, ADAM (A disintegrin and ..
  55. Serdaroglu G, Aydinok Y, Yilmaz S, Manco L, Ozer E. Triosephosphate isomerase deficiency: a patient with Val231Met mutation. Pediatr Neurol. 2011;44:139-42 pubmed publisher
    b>Triosephosphate isomerase deficiency constitutes a rare autosomal recessive disorder, characterized by hemolytic anemia, neurodegeneration, and recurrent bacterial infections...
  56. Gnerer J, Kreber R, Ganetzky B. wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death. Proc Natl Acad Sci U S A. 2006;103:14987-93 pubmed
    ..We demonstrate that the affected gene encodes the glycolytic enzyme, triosephosphate isomerase (Tpi)...
  57. Boyer T, Krug J, Maquat L. Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase. J Biol Chem. 1989;264:5177-87 pubmed
    To examine the functional organization of the human triosephosphate isomerase (TPI) promoter, deletion, insertion, and linker scanning mutations were introduced into the TPI promoter of hybrid TPI/beta-globin genes...
  58. Gozgor G. Does trade matter for carbon emissions in OECD countries? Evidence from a new trade openness measure. Environ Sci Pollut Res Int. 2017;: pubmed publisher
    ..trade openness, the paper uses a different trade openness measure, so called as the "trade potential index" (TPI)...
  59. da Silva M, de Oliveira Silva R, Ferreira Neto J, Benko Iseppon A, Kido E. Genotype-dependent regulation of drought-responsive genes in tolerant and sensitive sugarcane cultivars. Gene. 2017;633:17-27 pubmed publisher
    ..TRX); fatty acid synthesis (ACC); amino acid transport (AAT), and carbohydrate metabolism [glycolysis (PFK, TPI, FBA); TCA cycle (LDP, MDH); pentose phosphate pathway (TKT)]...
  60. Qian X, Shi Q, Pang B, Wu R, Yu L, Li S, et al. [Identification and expression of two new secretory proteins associated with prostate cancer]. Yi Chuan. 2010;32:235-41 pubmed
    ..Two overexpressed molecules-triosephosphate isomerase 1 (TPI1) and syndecan bind-ing protein, syntenin (ST1)-in extra-cellular proteinogram of C4-2 were ..
  61. Soriano P, Bhattarai M, Vogler C, Hudali T. A Case of Trigger-Point Injection-Induced Hypokalemic Paralysis. Am J Case Rep. 2017;18:454-457 pubmed
    BACKGROUND Trigger-point injection (TPI) therapy is an effective modality for symptomatic treatment of myofascial pain. Serious adverse effects are rarely observed...
  62. Maquat L, Chilcote R, Ryan P. Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man. J Biol Chem. 1985;260:3748-53 pubmed
    ..From this small patient sampling, it can be concluded that the genetic basis for TP isomerase deficiency is heterogeneous. ..