TP53BP2

Summary

Gene Symbol: TP53BP2
Description: tumor protein p53 binding protein 2
Alias: 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, apoptosis-stimulating of p53 protein 2, BCL2-binding protein, apoptosis-stimulating protein of p53, 2, renal carcinoma antigen NY-REN-51, tumor suppressor p53-binding protein 2
Species: human
Products:     TP53BP2

Top Publications

  1. Benyamini H, Leonov H, Rotem S, Katz C, Arkin I, Friedler A. A model for the interaction between NF-kappa-B and ASPP2 suggests an I-kappa-B-like binding mechanism. Proteins. 2009;77:602-11 pubmed publisher
    ..key proteins in apoptosis regulation: the transcription factor NF-kappa-B (NFkappaB) and the proapoptotic protein ASPP2. The C-terminus of ASPP2 contains ankyrin repeats and SH3 domains (ASPP2(ANK-SH3)) that mediate interactions with ..
  2. Uhlmann Schiffler H, Kiermayer S, Stahl H. The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. Oncogene. 2009;28:2065-73 pubmed publisher
    ..We found that in human cells Ddx42p physically interacts with ASPP2, a major apoptosis inducer known to enhance p53 transactivation of proapoptotic genes...
  3. Lopez C, Ao Y, Rohde L, Perez T, O Connor D, Lu X, et al. Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53. Mol Cell Biol. 2000;20:8018-25 pubmed
    ..b>53BP2, a p53-interacting protein, enhances p53 transactivation, impedes cell cycle progression, and promotes apoptosis ..
  4. Liu Z, Lu X, Zhang Y, Zhong S, Gu S, Zhang X, et al. Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53. FEBS Lett. 2005;579:1587-90 pubmed
    The p53 protein is one of the best-known tumour suppressors. Recently discovered ASPP1 and ASPP2 are specific activators of p53...
  5. Zhu Z, Ramos J, Kampa K, Adimoolam S, Sirisawad M, Yu Z, et al. Control of ASPP2/(53BP2L) protein levels by proteasomal degradation modulates p53 apoptotic function. J Biol Chem. 2005;280:34473-80 pubmed
    The p53 pathway is a central mediator of the apoptotic response. ASPP2/(53BP2L) (apoptosis-stimulating protein of p53 2, also known as 53BP2L) enhances apoptosis through selective stimulation of p53 transactivation of proapoptotic target ..
  6. Hershko T, Chaussepied M, Oren M, Ginsberg D. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Cell Death Differ. 2005;12:377-83 pubmed
    ..We show that E2F1 upregulates the expression of four proapoptotic cofactors of p53--ASPP1, ASPP2, JMY and TP53INP1--through a direct transcriptional mechanism...
  7. Takahashi N, Kobayashi S, Kajino S, Imai K, Tomoda K, Shimizu S, et al. Inhibition of the 53BP2S-mediated apoptosis by nuclear factor kappaB and Bcl-2 family proteins. Genes Cells. 2005;10:803-11 pubmed
    The p53 binding protein 2 (53BP2) has been identified independently as the interacting protein to p53, Bcl-2, and p65 subunit of nuclear factor kappaB (NF-kappaB)...
  8. Wang Z, Liu Y, Takahashi M, Van Hook K, Kampa Schittenhelm K, Sheppard B, et al. N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence. Proc Natl Acad Sci U S A. 2013;110:312-7 pubmed publisher
    The ASPP2 (also known as 53BP2L) tumor suppressor is a proapoptotic member of a family of p53 binding proteins that functions in part by enhancing p53-dependent apoptosis via its C-terminal p53-binding domain...
  9. Tidow H, Andreeva A, Rutherford T, Fersht A. Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold. J Mol Biol. 2007;371:948-58 pubmed
    Proteins of the ASPP family bind to p53 and regulate p53-mediated apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic functions while iASPP shows anti-apoptotic responses...

More Information

Publications90

  1. Samuels Lev Y, O Connor D, Bergamaschi D, Trigiante G, Hsieh J, Zhong S, et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell. 2001;8:781-94 pubmed
    We identified a family of proteins termed ASPP. ASPP1 is a protein homologous to 53BP2, the C-terminal half of ASPP2. ASPP proteins interact with p53 and specifically enhance p53-induced apoptosis but not cell cycle arrest...
  2. Espanel X, Sudol M. Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. J Biol Chem. 2001;276:14514-23 pubmed
    ..p53BP-2 complex. ..
  3. Rotem S, Katz C, Benyamini H, Lebendiker M, Veprintsev D, Rudiger S, et al. The structure and interactions of the proline-rich domain of ASPP2. J Biol Chem. 2008;283:18990-9 pubmed publisher
    b>ASPP2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response...
  4. Yang J, Hori M, Takahashi N, Kawabe T, Kato H, Okamoto T. NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2. Oncogene. 1999;18:5177-86 pubmed
    ..Here we report that 53BP2, a protein previously identified by interaction with wild type p53 and Bcl-2, also binds to p65 in a yeast two-..
  5. Katz C, Benyamini H, Rotem S, Lebendiker M, Danieli T, Iosub A, et al. Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. Proc Natl Acad Sci U S A. 2008;105:12277-82 pubmed publisher
    We have characterized the molecular basis of the interaction between ASPP2 and Bcl-2, which are key proteins in the apoptotic pathway...
  6. Naumovski L, Cleary M. The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M. Mol Cell Biol. 1996;16:3884-92 pubmed
    ..Bbp is identical to 53BP2, a partial clone of which was previously isolated in a two-hybrid screen for proteins that interact with p53...
  7. Helps N, Barker H, Elledge S, Cohen P. Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. FEBS Lett. 1995;377:295-300 pubmed
    The p53 binding protein, termed p53BP2, was identified as a protein interacting with protein phosphatase 1 (PP1) in the yeast two hybrid system...
  8. Li S, Shi G, Yuan H, Zhou T, Zhang Q, Zhu H, et al. Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP. Oncol Rep. 2012;28:133-40 pubmed publisher
    The p53 protein is one of the best-known tumor suppressors. Recently discovered ASPP1 and ASPP2 are specific activators and iASPP is an inhibitor of p53...
  9. Liu C, Lv X, Li T, Xu Y, Zhou X, Zhao S, et al. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem. 2011;286:5558-66 pubmed publisher
    ..Furthermore, ASPP2 facilitates the interaction between TAZ and PP1 to promote TAZ dephosphorylation...
  10. Chen D, Padiernos E, Ding F, Lossos I, Lopez C. Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene. Cell Death Differ. 2005;12:358-68 pubmed
    ..However, the mechanisms coupling the p53 and Rb/E2F pathways remain incompletely understood. We report that ASPP2/53BP2L, a p53/p73-binding protein that promotes p53/p73-dependent apoptosis, is an E2F target gene...
  11. Wang Y, Godin Heymann N, Dan Wang X, Bergamaschi D, Llanos S, Lu X. ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells. Cell Death Differ. 2013;20:525-34 pubmed publisher
    ..Additionally, ASPP2 colocalises with and contributes to RAS cellular membrane localisation and potentiates RAS signalling...
  12. Rotem Bamberger S, Katz C, Friedler A. Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism. PLoS ONE. 2013;8:e58470 pubmed publisher
    b>ASPP2 is a key protein in regulating apoptosis both in p53-dependent and-independent pathways...
  13. Gorina S, Pavletich N. Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science. 1996;274:1001-5 pubmed
    ..The core domain contains the sequence-specific DNA binding activity and the in vitro 53BP2 protein binding activity of p53...
  14. Fogal V, Kartasheva N, Trigiante G, Llanos S, Yap D, Vousden K, et al. ASPP1 and ASPP2 are new transcriptional targets of E2F. Cell Death Differ. 2005;12:369-76 pubmed
    ..We show here that E2F-1 binds in vivo the promoters of ASPP1 and ASPP2 genes, two activators of p53-mediated apoptosis, E2F-1, E2F-2 and E2F-3 all activate the isolated ASPP1 and ASPP2 ..
  15. Skene Arnold T, Luu H, Uhrig R, De Wever V, Nimick M, Maynes J, et al. Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins. Biochem J. 2013;449:649-59 pubmed publisher
    ..Human ASPPs (apoptosis-stimulating proteins of p53) comprise three family members: ASPP1, ASPP2 and iASPP (inhibitory ASPP), which is uniquely overexpressed in many cancers...
  16. Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X. ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol. 2004;24:1341-50 pubmed
    We recently showed that ASPP1 and ASPP2 stimulate the apoptotic function of p53. We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53...
  17. Robinson R, Lu X, Jones E, Siebold C. Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73. Structure. 2008;16:259-68 pubmed publisher
    ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53...
  18. Mori T, Okamoto H, Takahashi N, Ueda R, Okamoto T. Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines. FEBS Lett. 2000;465:124-8 pubmed
    The p53-binding protein 2 (53BP2) was identified as a binding protein to a tumor suppressor p53. We examined the genetic aberrations of 53BP2 gene in various human cancer cell lines...
  19. Wang Y, Bu F, Royer C, Serres S, Larkin J, Soto M, et al. ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1. Nat Cell Biol. 2014;16:1092-104 pubmed publisher
    ..Here we identify ASPP2, a haploinsufficient tumour suppressor, p53 activator and PAR3 binding partner, as a molecular switch of MET and ..
  20. Llanos S, Royer C, Lu M, Bergamaschi D, Lee W, Lu X. Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif. J Biol Chem. 2011;286:43039-44 pubmed publisher
    ..b>ASPP2 interacts with PP1 through an RVXF PP1 binding motif, whereas the inhibitory member of the ASPP family (iASPP) ..
  21. Zhao J, Wu G, Bu F, Lu B, Liang A, Cao L, et al. Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma. Hepatology. 2010;51:142-53 pubmed publisher
    ..This study evaluated the epigenetic regulation of ASPP1 and ASPP2 in hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC) and explores the effects of down-regulation of ..
  22. Yang X, Qian S, Yao K, Wang L, Liu Y, Dong F, et al. Multiresistant ST59-SCCmec IV-t437 clone with strong biofilm-forming capacity was identified predominantly in MRSA isolated from Chinese children. BMC Infect Dis. 2017;17:733 pubmed publisher
    ..0%), icaD (97.3%), fnbpA (100.0%), fnbpB (0), clfA (100%), clfB (100%), cna (2.7%), bbp (0), ebpS (88.5%), sdrC (78.4%), sdrD (5.4%), and sdrE (94.5%)...
  23. Querobino S, Ribeiro C, Alberto Silva C. Bradykinin-potentiating PEPTIDE-10C, an argininosuccinate synthetase activator, protects against H2O2-induced oxidative stress in SH-SY5Y neuroblastoma cells. Peptides. 2018;103:90-97 pubmed publisher
    ..b>BBP-10c increased AsS expression and was not neuroprotective in the presence of MDLA, a specific inhibitor of AsS...
  24. Zhang X, Wu M, Zhuo W, Gu J, Zhang S, Ge J, et al. Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen α. Protein Cell. 2015;6:757-66 pubmed publisher
    Bone sialoprotein-binding protein (Bbp), a MSCRAMMs (Microbial Surface Components Recognizing Adhesive Matrix Molecules) family protein expressed on the surface of Staphylococcus aureus (S...
  25. Russo M, Avino P, Notardonato I. Fast analysis of phthalates in freeze-dried baby foods by ultrasound-vortex-assisted liquid-liquid microextraction coupled with gas chromatography-ion trap/mass spectrometry. J Chromatogr A. 2016;1474:1-7 pubmed publisher
    ..Particularly, the whole procedure allows the determination of six phthalates such as DMP, DEP, DBP, iBcEP, BBP and DEHP. After dissolution of 0...
  26. Jeddi M, Rastkari N, Ahmadkhaniha R, Yunesian M. Endocrine disruptor phthalates in bottled water: daily exposure and health risk assessment in pregnant and lactating women. Environ Monit Assess. 2016;188:534 pubmed publisher
    ..phthalates including bis-(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and benzyl butyl phthalate (BBP), in bottled water and its corresponding health risks in pregnant and lactating women...
  27. Takahashi N, Kobayashi S, Jiang X, Kitagori K, Imai K, Hibi Y, et al. Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing. Biochem Biophys Res Commun. 2004;315:434-8 pubmed
    ..We have previously found that the TP53BP2 gene encoding 53BP2 protein is a single copy gene and has been mapped to the long arm of chromosome 1 at q42.1...
  28. Otero P, Saha S, Moane S, Barron J, Clancy G, Murray P. Improved method for rapid detection of phthalates in bottled water by gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;997:229-35 pubmed publisher
    ..for bis (2-n-butoxyethyl) phthalate (DBEP), bis (2-n-ethylhexyl) phthalate (DEHP), butyl benzyl phthalate (BBP), di-butyl phthalate (DBP), diethyl phthalate (DEP), dihexyl phthalate (DHP), dimethyl phthalate (DMP), di-n-octyl ..
  29. Kiani A, Ahmadloo M, Shariatifar N, Moazzen M, Baghani A, Khaniki G, et al. Method development for determination of migrated phthalate acid esters from polyethylene terephthalate (PET) packaging into traditional Iranian drinking beverage (Doogh) samples: a novel approach of MSPE-GC/MS technique. Environ Sci Pollut Res Int. 2018;25:12728-12738 pubmed publisher
    ..extractable migrated phthalate esters (dibutyl phthalate (DBP), dimethyl phthalate (DMP), butyl benzyl phthalate (BBP), diethyl phthalate (DEP), di-N-octyl phthalate (DNOP), and bis (2-ethylhexyl) phthalate (DEHP)) from polyethylene ..
  30. Mak V, Lee L, Siu M, Wong O, Lu X, Ngan H, et al. Downregulation of ASPP2 in choriocarcinoma contributes to increased migratory potential through Src signaling pathway activation. Carcinogenesis. 2013;34:2170-7 pubmed publisher
    ..Apoptosis-stimulating protein of p53-2 (ASPP2) is a member of ASPP family that transactivates p53 and thereby functions as a tumor suppressor...
  31. Nakagomi M, Suzuki E, Saito Y, Nagao T. Endocrine disrupting chemicals, 4-nonylphenol, bisphenol A and butyl benzyl phthalate, impair metabolism of estradiol in male and female rats as assessed by levels of 15?-hydroxyestrogens and catechol estrogens in urine. J Appl Toxicol. 2017;: pubmed publisher
    Bisphenol A (BPA), 4-nonylphenol (NP) and butyl benzyl phthalate (BBP), termed endocrine-disrupting chemicals, are known to mimic estrogen activity...
  32. Godin Heymann N, Wang Y, Slee E, Lu X. Phosphorylation of ASPP2 by RAS/MAPK pathway is critical for its full pro-apoptotic function. PLoS ONE. 2013;8:e82022 pubmed publisher
    ..However, the detailed mechanism remains unknown. Here we show that ASPP2 is a novel substrate of mitogen-activated protein kinase (MAPK)...
  33. Goble D, Khan E, Baweja H, O Connor S. A point of application study to determine the accuracy, precision and reliability of a low-cost balance plate for center of pressure measurement. J Biomech. 2018;71:277-280 pubmed publisher
    ..of ∼155 N of force was applied five times to each of 21 points on five different BTrackS Balance Plate (BBP) devices with a hex-nose plunger. Results showed excellent agreement (ICC > 0...
  34. Chen R, Wang H, Liang B, Liu G, Tang M, Jia R, et al. Downregulation of ASPP2 improves hepatocellular carcinoma cells survival via promoting BECN1-dependent autophagy initiation. Cell Death Dis. 2016;7:e2512 pubmed publisher
    ..we identify the ankyrin-repeat-containing, SH3-domain-containing, and proline-rich region-containing protein 2 (ASPP2), a haploinsufficient tumor suppressor, as a molecular regulator of starvation-induced autophagy in hepatocellular ..
  35. Iwabuchi K, Bartel P, Li B, Marraccino R, Fields S. Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci U S A. 1994;91:6098-102 pubmed
    ..the yeast two-hybrid system, we identified two previously uncharacterized human proteins, designated 53BP1 and 53BP2, that bind to p53...
  36. Liu X, Wang S, Guo X, Wei F, Yin J, Zang Y, et al. Exogenous p53 and ASPP2 expression enhances rAdV-TK/ GCV-induced death in hepatocellular carcinoma cells lacking functional p53. Oncotarget. 2016;7:18896-905 pubmed publisher
    ..Using recombinant adenoviral vectors (rAdV), TK, p53, and ASPP2 were overexpressed individually and in combination in Hep3B (p53 null) and HepG2 (p53 wild-type) cell lines and in ..
  37. Belghith Fendri L, Chaari F, Kallel F, Zouari Ellouzi S, Ghorbel R, Besbes S, et al. Pea and Broad Bean Pods as a Natural Source of Dietary Fiber: The Impact on Texture and Sensory Properties of Cake. J Food Sci. 2016;81:C2360-C2366 pubmed publisher
    ..mediterranean (Tunisian), has been studied for its high dietary fiber content (PP: 43.87 g/100 g; BBP: 53.01 g/100 g). Protein content was also a considerable component for both by-products...
  38. Schittenhelm M, Illing B, Ahmut F, Rasp K, Blumenstock G, Dohner K, et al. Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure. PLoS ONE. 2013;8:e80193 pubmed publisher
    ..The Apoptosis Stimulating Protein of p53-2 (ASPP2) is a damage-inducible p53-binding protein that enhances apoptosis at least in part through a p53-mediated pathway...
  39. Snezhkina A, Lukyanova E, Kalinin D, Pokrovsky A, Dmitriev A, Koroban N, et al. Exome analysis of carotid body tumor. BMC Med Genomics. 2018;11:17 pubmed publisher
    ..BRAF, BRCA1, BRCA2, CDKN2A, CSDE1, FGFR3, IDH1, KIF1B, KMT2D, MEN1, RET, SDHA, SDHB, SDHC, SDHD, SETD2, TP53BP1, TP53BP2, and TP53I13. In many samples, more than one PDM was identified...
  40. Ozer E, Osman B, Yazıcı T. Dummy molecularly imprinted microbeads as solid-phase extraction material for selective determination of phthalate esters in water. J Chromatogr A. 2017;1500:53-60 pubmed publisher
    ..of dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), benzylbutyl phthalate (BBP), di-(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DnOP) in aqueous media by using the PEMATrp DMIMs as ..
  41. Hakuno F, Kurihara S, Watson R, Pessin J, Takahashi S. 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling. J Biol Chem. 2007;282:37747-58 pubmed
    ..Out of 109 cDNA-positive clones identified from a human placental cDNA library, two clones encoded 53BP2, p53-binding protein 2 (53BP2S), a short form splicing variant of the apoptosis-stimulating protein of p53 that ..
  42. Zick A, Kadouri L, Cohen S, Frohlinger M, Hamburger T, Zvi N, et al. Recurrent TP53 missense mutation in cancer patients of Arab descent. Fam Cancer. 2017;16:295-301 pubmed publisher
    ..The R181C variant is expected to disrupt p53 at the ASPP2 binding domain but not the DNA binding domain and is defined by Clinvar as likely pathogenic and in HGMD as ..
  43. Beltifa A, Feriani A, Macherki M, Ghorbel A, Ghazouani L, Di Bella G, et al. Persistent plasticizers and bisphenol in the cheese of Tunisian markets induced biochemical and histopathological alterations in male BALB/c mice. Environ Sci Pollut Res Int. 2018;25:6545-6557 pubmed publisher
    ..an inner surface plastic-covered film in order to identify the dibutyl phthalate (DBP); benzyl butyl phthalate (BBP); bis(2-ethylhexyl) phthalate (DEHP); diisodecyl phthalate (DiDP); diisononyl phthalate (DiNP); and 1,2-cyclohexane ..
  44. Herrero Ã, Planelló R, Morcillo G. The ribosome biogenesis pathway as an early target of benzyl butyl phthalate (BBP) toxicity in Chironomus riparius larvae. Chemosphere. 2016;144:1874-84 pubmed publisher
    Butyl benzyl phthalate (BBP) is a ubiquitous contaminant whose presence in the environment is expected for decades, since it has been extensively used worldwide as a plasticizer in the polyvinyl chloride (PVC) industry and the ..
  45. Czernych R, Chraniuk M, Zagożdżon P, Wolska L. Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES/YAS in vitro assay. Environ Toxicol Pharmacol. 2017;53:95-104 pubmed publisher
    ..Investigation of estrogenic and androgenic activities of phthalates (DEP, DBP, BBP, DEHP and DINP) showed no significant effect of tested substances either on hER? or hAR receptors...
  46. Xu R, Gao H, Zhu F, Cao W, Yan Y, Zhou X, et al. SPE-UPLC-MS/MS for the determination of phthalate monoesters in rats urine and its application to study the effects of food emulsifier on the bioavailability of priority controlling PAEs. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1012-1013:97-105 pubmed publisher
    ..05 except for butyl benzyl phthalates (BBP) (P=0.07). The bioavailability of all PAEs ranged from 5.03% to 109...
  47. Park Y, Choi M, Rehman S, Gye M, Yoo H. Simultaneous GC-MS determination of seven phthalates in total and migrated portions of paper cups. Environ Sci Pollut Res Int. 2016;23:10270-5 pubmed publisher
    ..In this study, the content of seven phthalates, dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), di-(2-ethylhexyl) adipate (DEHA), di-2-ethylhexyl phthalate (DEHP), di-n-octyl phthalate (DNOP), di-isononyl ..
  48. Goudarzi M, Seyedjavadi S, Nasiri M, Goudarzi H, Sajadi Nia R, Dabiri H. Molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from patients with bacteremia based on MLST, SCCmec, spa, and agr locus types analysis. Microb Pathog. 2017;104:328-335 pubmed publisher
    ..Conventional PCR was performed for the detection of adhesion (can, bbp, ebp, fnbB, fnbA, clfB, clfA) and toxin (etb, eta, pvl, tst) encoding genes, determining the agr type, SCCmec, MLST ..
  49. Song X, Du J, Zhu W, Jin P, Ma F. Identification and characterization of an apoptosis-stimulating protein of p53 (ASPP) gene from Branchiostoma belcheri: Insights into evolution of ASPP gene family. Fish Shellfish Immunol. 2016;49:268-74 pubmed publisher
    ..that amphioxus ASPP protein could interact with REL protein by conserved binding sites compared with human ASPP2 protein, which seemed to further suggest that the amphioxus ASPP protein involve in innate immunity through NF-к..
  50. Yao Q, Sandhurst E, Liu Y, Sun H. BBP-Functionalized Biomimetic Nanofibrous Scaffold Can Capture BMP2 and Promote Osteogenic Differentiation. J Mater Chem B Mater Biol Med. 2017;5:5196-5205 pubmed publisher
    ..separation together with a porogen leaching technique (TIPS&P) and functionalized by a BMP-binding peptide (BBP) through cross-linking...
  51. Zaki G, Shoeib T. Concentrations of several phthalates contaminants in Egyptian bottled water: Effects of storage conditions and estimate of human exposure. Sci Total Environ. 2018;618:142-150 pubmed publisher
    ..were dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), n-butyl benzyl phthalate (BBP), diethyl hexyl phthalate (DEHP), and Di-n-octyl phthalate (D-n-OP)...
  52. Li T, Santockyte R, Shen R, Tekle E, Wang G, Yang D, et al. A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. Arch Biochem Biophys. 2006;453:70-4 pubmed
    ..Most of the E1-like activating enzymes, E2-like conjugating enzymes and the majorities of the known target as well as some previously unreported proteins for SUMO-2, SUMO-3, and NEDD8 pathways were identified. ..
  53. Liu Z, Lu X, Zhong S. ASPP--Apoptotic specific regulator of p53. Biochim Biophys Acta. 2005;1756:77-80 pubmed
    ..The discovery of ASPP family may answer such questions as "how cells choose to die". Understanding the ASPP status in human cancer will allow us to develop better strategies to treat cancer. ..
  54. Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer H, et al. Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). J Cell Sci. 2013;126:2629-40 pubmed publisher
    ..In addition, ASPP2 was shown to be important for the regulation of cell polarity through interaction with partitioning defective 3 ..
  55. Lu M, Zak J, Chen S, Sanchez Pulido L, Severson D, Endicott J, et al. A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. Cell. 2014;157:1130-45 pubmed publisher
    ..The RaDAR (RanGDP/AR) pathway represents a general importin-independent nuclear import pathway and is frequently used by AR-containing transcriptional regulators, especially those regulating NF-?B/p53. ..
  56. Bush C, Schmid K, Rupp M, Watanabe Galloway S, Wolford B, Sandkovsky U. Bloodborne pathogen exposures: Difference in reporting rates and individual predictors among health care personnel. Am J Infect Control. 2017;45:372-376 pubmed publisher
    Employees in health care settings are at varying risk for bloodborne pathogen (BBP) exposures...
  57. Van Hook K, Wang Z, Chen D, Nold C, Zhu Z, Anur P, et al. ?N-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival. Biochem Biophys Res Commun. 2017;482:1271-1277 pubmed publisher
    b>ASPP2 is a tumor suppressor that works, at least in part, through enhancing p53-dependent apoptosis...
  58. Xie F, Jia L, Lin M, Shi Y, Yin J, Liu Y, et al. ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease. J Cell Mol Med. 2015;19:155-64 pubmed publisher
    b>ASPP2 is a pro-apoptotic member of the p53 binding protein family. ASPP2 has been shown to inhibit autophagy, which maintains energy balance in nutritional deprivation...
  59. Chow N, Korenberg J, Chen X, Neve R. APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein. J Biol Chem. 1996;271:11339-46 pubmed
  60. Yang J, Ono T, Sonta S, Kawabe T, Okamoto T. Assignment of p53 binding protein (TP53BP2) to human chromosome band 1q42.1 by in situ hybridization. Cytogenet Cell Genet. 1997;78:61-2 pubmed
  61. Buti L, Spooner E, van der Veen A, Rappuoli R, Covacci A, Ploegh H. Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proc Natl Acad Sci U S A. 2011;108:9238-43 pubmed publisher
    ..Here, we show that CagA subverts the tumor suppressor function of apoptosis-stimulating protein of p53 (ASPP2). Delivery of CagA inside the host results in its association with ASPP2...
  62. Zak J, Vives V, Szumska D, Vernet A, Schneider J, Miller P, et al. ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome. Cell Death Differ. 2016;23:1973-1984 pubmed publisher
    ..Here, our detailed analysis of the genetic abnormalities of 1q41q42 microdeletion cases identified TP53BP2, which encodes apoptosis-stimulating protein of p53 2 (ASPP2), as a candidate gene for brain abnormalities...
  63. González Sálamo J, Socas Rodríguez B, Hernandez Borges J, Rodriguez Delgado M. Determination of phthalic acid esters in water samples using core-shell poly(dopamine) magnetic nanoparticles and gas chromatography tandem mass spectrometry. J Chromatogr A. 2017;: pubmed publisher
    ..dibutyl phthalate (DBP), bis-isopentyl phthalate (DIPP), bis-n-pentyl phthalate (DNPP), benzylbutyl phthalate (BBP), dicyclohexyl phthalate (DCHP), di-(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), diisononyl ..
  64. Romano N, Ricciardi S, Gallo P, Ceci M. Upregulation of eIF6 inhibits cardiac hypertrophy induced by phenylephrine. Biochem Biophys Res Commun. 2018;495:601-606 pubmed publisher
    ..Here we report the effect of a translational modulator, eIF6/p27BBP in the hypertrophy of neonatal rat CMCs...
  65. O Connor S, Baweja H, Goble D. Validating the BTrackS Balance Plate as a low cost alternative for the measurement of sway-induced center of pressure. J Biomech. 2016;49:4142-4145 pubmed publisher
    The BTrackS Balance Plate (BBP) is a low-cost force plate that provides objective balance assessment and true portability for the user...
  66. Yan Z, He M, Chen B, Gui B, Wang C, Hu B. Magnetic covalent triazine framework for rapid extraction of phthalate esters in plastic packaging materials followed by gas chromatography-flame ionization detection. J Chromatogr A. 2017;1525:32-41 pubmed publisher
    ..including dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), benzyl butyl phthalate (BBP), di-2-ethylhexl phthalate (DEHP), and di-n-octyl phthalate (DNOP) in plastic packaging materials...
  67. Buñay J, Larriba E, Patiño Garcia D, Cruz Fernandes L, Castañeda Zegarra S, Rodriguez Fernandez M, et al. Differential Effects of Exposure to Single versus a Mixture of Endocrine-Disrupting Chemicals on Steroidogenesis Pathway in Mouse Testes. Toxicol Sci. 2017;: pubmed publisher
    ..Pregnant mice were exposed through drinking water to: 0.3?mg/Kg-body weight (BW)/day of each phthalate (DEHP, DBP, BBP), 0.05?mg/Kg-BW/day of each alkylphenol (NP, OP), or their mixture, covering from 0...
  68. Sun G, Liu K. Developmental toxicity and cardiac effects of butyl benzyl phthalate in zebrafish embryos. Aquat Toxicol. 2017;192:165-170 pubmed publisher
    ..However, relatively little is known about the phthalates effects on the heart. Butyl benzyl phthalate (BBP), a member of PAEs, is classified by the US Environmental Protection Agency as a priority environmental pollutant...
  69. Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, et al. ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer. Cancer Lett. 2017;398:52-61 pubmed publisher
    b>ASPP2 regulates cell polarity and cell-cell adhesion by binding to, and co-localizing with PAR3 at tight junctions. Here we show a novel role of ASPP2 in suppressing gastric cancer (GC) invasiveness...
  70. Liu K, Lin D, Ouyang Y, Pang L, Guo X, Wang S, et al. Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression-induced apoptosis in hepatoma cells. Tumour Biol. 2017;39:1010428317695026 pubmed publisher
    Overexpression of apoptosis-stimulating protein 2 of p53 (ASPP2) induces apoptotic cell death in hepatoma cells (e.g...
  71. Wang X, Yu M, Zhao K, He M, Ge W, Sun Y, et al. Upregulation of MiR-205 under hypoxia promotes epithelial-mesenchymal transition by targeting ASPP2. Cell Death Dis. 2016;7:e2517 pubmed publisher
    ..Here, we identified that apoptosis-stimulating protein of p53-2 (ASPP2) is a novel target of MiR-205 in various cancers...
  72. Zhang J, Cheng M, Ji D, Liu Z, Hu B, Sun Y, et al. Characterization of submicron particles during biomass burning and coal combustion periods in Beijing, China. Sci Total Environ. 2016;562:812-821 pubmed publisher
    ..matter with a vacuum aerodynamic diameter of ≤1μm) during the biomass burning period (October 1 to 27; BBP) and the coal combustion period (December 10 to 31; CCP) in Beijing in 2014...
  73. Royer C, Koch S, Qin X, Zak J, Buti L, Dudziec E, et al. ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells. PLoS ONE. 2014;9:e111384 pubmed publisher
    ..Here we report that the tumour suppressor ASPP2 forms an apical-lateral polarity complex at the level of tight junctions in polarised epithelial cells, acting as ..
  74. Meng W, Chu R, Wang B, Wang L, Ma L, Wang L. Helicobacter pylori infection and expressions of apoptosis-related proteins p53, ASPP2 and iASPP in gastric cancer and precancerous lesions. Pathol Biol (Paris). 2013;61:199-202 pubmed publisher
    ..Expression of apoptosis-related proteins P53, ASPP2 and iASPP in the gastric tissues were determined by immunohistochemistry. The concentrations of H...
  75. Nakagawa H, Koyama K, Murata Y, Morito M, Akiyama T, Nakamura Y. APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. Cancer Res. 2000;60:101-5 pubmed
    ..human fetal-brain cDNA library as candidates for interaction with APCL, 32 encoded parts of p53-binding protein 2 (53BP2), a molecule that interacts with p53 and Bcl2...
  76. Sun W, Hsieh P, Chiang M, Wang M, Wang F. p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation. Biochem Biophys Res Commun. 2008;376:395-8 pubmed publisher
    ..underlying DDA3 action, we searched for its interacting proteins by yeast two-hybrid screening, and identified ASPP2, a p53 binding protein, as its binding partner...
  77. Cheraghi S, Pourgholi L, Shafaati M, Fesharaki S, Jalali A, Nosrati R, et al. Analysis of virulence genes and accessory gene regulator (agr) types among methicillin-resistant Staphylococcus aureus strains in Iran. J Glob Antimicrob Resist. 2017;10:315-320 pubmed publisher
    ..Furthermore, the most frequent adhesin genes were clfA, spa, cna, map/eap and bbp, found in 281 (94.9%), 275 (92.9%), 267 (90.2%), 265 (89.5%) and 264 (89.2%) isolates, respectively...
  78. Lin M, Chang Y, Xie F, Shi Y, Pang L, Chen D. ASPP2 Inhibits the Profibrotic Effects of Transforming Growth Factor-?1 in Hepatic Stellate Cells by Reducing Autophagy. Dig Dis Sci. 2018;63:146-154 pubmed publisher
    Apoptosis-stimulating protein of p53-2 (ASPP2) is a damage-inducible P53-binding protein that enhances damage-induced apoptosis...
  79. Jiang B, Wang Y, Feng Z, Xu L, Tan L, Zhao S, et al. Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus aureus Osteomyelitis. Front Microbiol. 2017;8:2355 pubmed publisher
    ..We found that some sequence types were specific to OM infection. The pvl, bbp, and ebps genes were associated with S. aureus OM prevalence...
  80. Gao K, An J, Zhang Y, Jin X, Ma J, Peng J, et al. The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability. FEBS Lett. 2015;589:94-101 pubmed publisher
    b>ASPP2 is an important tumor suppressor protein promoting p53-dependent and-independent apoptosis. However, it has been unclear how ASPP2 protein is regulated. Here, we identified Itch as the E3 ubiquitin ligase for ASPP2...
  81. Nesic D, Buti L, Lu X, Stebbins C. Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2. Proc Natl Acad Sci U S A. 2014;111:1562-7 pubmed publisher
    ..have demonstrated an association of CagA with the human tumor suppressor Apoptosis-stimulating Protein of p53-2 (ASPP2). We present here a genetic, biochemical, and structural analysis of CagA with ASPP2...