TP53BP1

Summary

Gene Symbol: TP53BP1
Description: tumor protein p53 binding protein 1
Alias: 53BP1, TDRD30, TP53, p202, p53BP1, TP53-binding protein 1, p53-binding protein 1, tumor protein 53-binding protein, 1, tumor suppressor p53-binding protein 1
Species: human
Products:     TP53BP1

Top Publications

  1. Celeste A, Fernandez Capetillo O, Kruhlak M, Pilch D, Staudt D, Lee A, et al. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol. 2003;5:675-9 pubmed
    ..Despite their initial recruitment to DSBs, numerous factors, including Nbs1, 53BP1 and Brca1, subsequently fail to form IRIF...
  2. Kao G, McKenna W, Guenther M, Muschel R, Lazar M, Yen T. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. J Cell Biol. 2003;160:1017-27 pubmed
    Anumber of proteins are recruited to nuclear foci upon exposure to double-strand DNA damage, including 53BP1 and Rad51, but the precise role of these DNA damage-induced foci remain unclear...
  3. Lai T, Chow K, Lin T, Chiang I, Fang H, Chen C, et al. Expression of 53BP1 as a cisplatin-resistant marker in patients with lung adenocarcinomas. Oncol Rep. 2010;24:321-8 pubmed
    ..b>53BP1 is a mediator that relays signals from DNA damage sensors and activates various effectors for the DNA repair and ..
  4. Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, et al. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature. 2011;470:124-8 pubmed publisher
    p53-binding protein 1 (53BP1) is known to be an important mediator of the DNA damage response, with dimethylation of histone H4 lysine 20 (H4K20me2) critical to the recruitment of 53BP1 to double-strand breaks (DSBs)...
  5. Harrigan J, Belotserkovskaya R, Coates J, Dimitrova D, Polo S, Bradshaw C, et al. Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol. 2011;193:97-108 pubmed publisher
    ..Here, we show that in G1 cells, large nuclear bodies arise that contain p53 binding protein 1 (53BP1), phosphorylated H2AX (?H2AX), and mediator of DNA damage checkpoint 1 (MDC1), as well as ..
  6. Fernandez Capetillo O, Chen H, Celeste A, Ward I, Romanienko P, Morales J, et al. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol. 2002;4:993-7 pubmed
    ..Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in signalling the ..
  7. van Vugt M, Gardino A, Linding R, Ostheimer G, Reinhardt H, Ong S, et al. A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol. 2010;8:e1000287 pubmed publisher
    ..We demonstrate that the non-enzymatic checkpoint adaptor protein 53BP1 is an in vivo target of the cell cycle kinases Cyclin-dependent kinase-1 and Polo-like kinase-1 (Plk1)...
  8. Jung S, Malovannaya A, Wei J, O Malley B, Qin J. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol. 2005;19:2451-65 pubmed
    ..We hope that the electronic availability of these data to the general scientific community will facilitate generation and testing of new hypotheses to further our understanding of nuclear receptor signaling and coactivator functions. ..
  9. Ward I, Kim J, Minn K, Chini C, Mer G, Chen J. The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem. 2006;281:38472-7 pubmed
    b>53BP1 plays an important role in cellular response to DNA damage. It is thought to be the mammalian homologue of budding yeast Rad9 and/or fission yeast Crb2...

More Information

Publications65

  1. Bartkova J, Horejsi Z, Sehested M, Nesland J, Rajpert De Meyts E, Skakkebaek N, et al. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene. 2007;26:7414-22 pubmed
    MDC1 and 53BP1 are critical components of the DNA damage response (DDR) machinery that protects genome integrity and guards against cancer, yet the tissue expression patterns and involvement of these two DDR adaptors/mediators in human ..
  2. Nakashima M, Suzuki K, Meirmanov S, Naruke Y, Matsuu Matsuyama M, Shichijo K, et al. Foci formation of P53-binding protein 1 in thyroid tumors: activation of genomic instability during thyroid carcinogenesis. Int J Cancer. 2008;122:1082-8 pubmed
    ..P53-binding protein 1 (53BP1) belongs to a family of evolutionarily conserved DDR proteins...
  3. Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller K, Jackson S. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature. 2009;462:935-9 pubmed publisher
    ..H2AX (also known as H2AFX) phosphorylation and the accumulation of proteins such as MDC1, 53BP1 (also known as TP53BP1), BRCA1, CtIP (also known as RBBP8), RNF8 and RNF168/RIDDLIN into ionizing radiation-induced foci (IRIF) that ..
  4. Bouwman P, Aly A, Escandell J, Pieterse M, Bartkova J, van der Gulden H, et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol. 2010;17:688-95 pubmed publisher
    ..Here we identify p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced by Brca1 deletion...
  5. Xia Z, Morales J, Dunphy W, Carpenter P. Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1. J Biol Chem. 2001;276:2708-18 pubmed
    In a screen designed to discover suppressors of mitotic catastrophe, we identified the Xenopus ortholog of 53BP1 (X53BP1), a BRCT protein previously identified in humans through its ability to bind the p53 tumor suppressor...
  6. Chapman J, Sossick A, Boulton S, Jackson S. BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair. J Cell Sci. 2012;125:3529-34 pubmed
    ..Here, we use super-resolution microscopy to examine the spatial distribution of BRCA1 and 53BP1 proteins within single IRIF at subdiffraction-limit resolution, yielding an unprecedented increase in detail that ..
  7. Noon A, Shibata A, Rief N, Lobrich M, Stewart G, Jeggo P, et al. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat Cell Biol. 2010;12:177-84 pubmed publisher
    ..b>53BP1 (p53-binding protein 1) facilitates ATM-dependent DSB repair but is largely dispensable for ATM activation or ..
  8. Pan S, Cheng L, White J, Lu W, Utleg A, Yan X, et al. Quantitative proteomics analysis integrated with microarray data reveals that extracellular matrix proteins, catenins, and p53 binding protein 1 are important for chemotherapy response in ovarian cancers. OMICS. 2009;13:345-54 pubmed publisher
    ..These include P53 binding protein 1, catenin delta 1 and plakoglobin, EGF-containing fibulin-like extracellular matrix protein 1 and voltage-..
  9. Lukas C, Savic V, Bekker Jensen S, Doil C, Neumann B, Pedersen R, et al. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol. 2011;13:243-53 pubmed publisher
    ..Throughout G1, these lesions are sequestered in nuclear compartments marked by p53-binding protein 1 (53BP1) and other chromatin-associated genome caretakers...
  10. Takeyama K, Monti S, Manis J, Dal Cin P, Getz G, Beroukhim R, et al. Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas. Oncogene. 2008;27:318-22 pubmed
    p53-Binding protein 1 (53BP1) encodes a critical checkpoint protein that localizes to sites of DNA double-strand breaks (DSBs) and participates in DSB repair...
  11. Fradet Turcotte A, Canny M, Escribano Diaz C, Orthwein A, Leung C, Huang H, et al. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature. 2013;499:50-4 pubmed publisher
    53BP1 (also called TP53BP1) is a chromatin-associated factor that promotes immunoglobulin class switching and DNA double-strand-break (DSB) repair by non-homologous end joining...
  12. Wang B, Matsuoka S, Carpenter P, Elledge S. 53BP1, a mediator of the DNA damage checkpoint. Science. 2002;298:1435-8 pubmed
    b>53BP1 binds to the tumor suppressor protein p53 and has a potential role in DNA damage responses...
  13. Peng A, Chen P. NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. J Biol Chem. 2003;278:8873-6 pubmed
    ..NFBD1 associates with nuclear foci within minutes following IR, a property similar to histone H2AX, 53BP1, and Chk2, which are all early participants in the DNA damage signaling cascade...
  14. Mochan T, Venere M, DiTullio R, Halazonetis T. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res. 2003;63:8586-91 pubmed
    b>53BP1 and NFBD1/MDC1 are recruited rapidly to sites of DNA double-strand breaks (DSBs), where they are hypothesized to function downstream of the ataxia-telangiectasia mutated (ATM) checkpoint kinase as "mediators" of DNA DSB ..
  15. Rauch T, Zhong X, Pfeifer G, Xu X. 53BP1 is a positive regulator of the BRCA1 promoter. Cell Cycle. 2005;4:1078-83 pubmed
    ..In this report we have identified an imperfect palindrome sequence for binding of the 53BP1-containing complex, -40TTCCGTGG CAACGGAA-25, within the BRCA1 minimal promoter...
  16. Joo W, Jeffrey P, Cantor S, Finnin M, Livingston D, Pavletich N. Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev. 2002;16:583-93 pubmed
    ..The DNA-damage response protein 53BP1 has two BRCT domains that bind to the DNA-binding domain of p53...
  17. Kiyohara C, Horiuchi T, Miyake Y, Takayama K, Nakanishi Y. Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population. Oncol Rep. 2010;23:1361-8 pubmed
    ..Tumor protein 53-binding protein 1 (TP53BP1) binds to TP53 and has a potential role in DNA damage responses...
  18. Iwabuchi K, Li B, Massa H, Trask B, Date T, Fields S. Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J Biol Chem. 1998;273:26061-8 pubmed
    ..In a previous study, we identified two proteins, 53BP1 and 53BP2, that are able to bind to wild type but not to mutant p53 via the DNA-binding domain of p53...
  19. Nakada S, Yonamine R, Matsuo K. RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1. Cancer Res. 2012;72:4974-83 pubmed publisher
    ..of the pivotal homologous recombination regulator RAD51 can occur independently of BRCA1 in the absence of 53BP1, another DNA damage response protein...
  20. Escribano D az C, Orthwein A, Fradet Turcotte A, Xing M, Young J, Tk J, et al. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell. 2013;49:872-83 pubmed publisher
    DNA double-strand break (DSB) repair pathway choice is governed by the opposing activities of 53BP1 and BRCA1. 53BP1 stimulates nonhomologous end joining (NHEJ), whereas BRCA1 promotes end resection and homologous recombination (HR)...
  21. Sengupta S, Robles A, Linke S, Sinogeeva N, Zhang R, Pedeux R, et al. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol. 2004;166:801-13 pubmed
    ..BLM colocalized and physically interacted with the DNA damage response proteins 53BP1 and H2AX...
  22. Pryde F, Khalili S, Robertson K, Selfridge J, Ritchie A, Melton D, et al. 53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin. J Cell Sci. 2005;118:2043-55 pubmed
    b>53BP1 protein is re-localized to the sites of DNA damage after ionizing radiation (IR) and is involved in DNA-damage-checkpoint signal transduction. We examined the dynamics of GFP-53BP1 in living cells...
  23. Huyen Y, Zgheib O, DiTullio R, Gorgoulis V, Zacharatos P, Petty T, et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature. 2004;432:406-11 pubmed
    ..b>53BP1 is a conserved checkpoint protein with properties of a DNA DSB sensor...
  24. Dimitrova N, Chen Y, Spector D, de Lange T. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature. 2008;456:524-8 pubmed publisher
    ..The functional significance of the resulting DNA damage foci is poorly understood. Here we show that 53BP1 (also known as TRP53BP1), a component of DNA damage foci, changes the dynamic behaviour of chromatin to promote ..
  25. Stewart G, Wang B, Bignell C, Taylor A, Elledge S. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003;421:961-6 pubmed
    ..cells lacking MDC1 are sensitive to ionizing radiation, and that MDC1 controls the formation of damage-induced 53BP1, BRCA1 and MRN foci, in part by promoting efficient H2AX phosphorylation...
  26. Lowndes N. The interplay between BRCA1 and 53BP1 influences death, aging, senescence and cancer. DNA Repair (Amst). 2010;9:1112-6 pubmed publisher
    ..The related 53BP1 gene is known to positively regulate repair of DSBs outside of S phase, but via the NHEJ pathway...
  27. Iwabuchi K, Basu B, Kysela B, Kurihara T, Shibata M, Guan D, et al. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J Biol Chem. 2003;278:36487-95 pubmed
    Upon DNA damage, p53-binding protein 1 (53BP1) relocalizes to sites of DNA double-strand breaks and forms discrete nuclear foci, suggesting its role in DNA damage responses...
  28. Zhang D, Zaugg K, Mak T, Elledge S. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell. 2006;126:529-42 pubmed
    ..Through analysis of 53BP1 complexes we have discovered a new ubiquitin protease, USP28, which regulates this pathway...
  29. Lottersberger F, Bothmer A, Robbiani D, Nussenzweig M, de Lange T. Role of 53BP1 oligomerization in regulating double-strand break repair. Proc Natl Acad Sci U S A. 2013;110:2146-51 pubmed publisher
    Tumor suppressor p53-binding protein 1 (53BP1) regulates the repair of dysfunctional telomeres lacking the shelterin protein TRF2 by promoting their mobility, their nonhomologous end-joining (NHEJ), and, as we show here, by blocking 5' ..
  30. Huen M, Grant R, Manke I, Minn K, Yu X, Yaffe M, et al. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 2007;131:901-14 pubmed
    ..35 A. We have shown that RNF8 facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 to the damaged chromatin, on one hand through the phospho-dependent FHA domain-mediated binding of RNF8 to MDC1, ..
  31. DiTullio R, Mochan T, Venere M, Bartkova J, Sehested M, Bartek J, et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol. 2002;4:998-1002 pubmed
    b>53BP1 is a conserved nuclear protein that is implicated in the DNA damage response. After irradiation, 53BP1 localizes rapidly to nuclear foci, which represent sites of DNA double strand breaks, but its precise function is unclear...
  32. Manke I, Lowery D, Nguyen A, Yaffe M. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science. 2003;302:636-9 pubmed
    ..PTIP tandem BRCT domains are responsible for phosphorylation-dependent protein localization into 53BP1- and phospho-H2AX (gamma-H2AX)-containing nuclear foci, a marker of DNA damage...
  33. Tang J, Cho N, Cui G, Manion E, Shanbhag N, Botuyan M, et al. Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol. 2013;20:317-25 pubmed publisher
    The pathogenic sequelae of BRCA1 mutation in human and mouse cells are mitigated by concomitant deletion of 53BP1, which binds histone H4 dimethylated at Lys20 (H4K20me2) to promote nonhomologous end joining, suggesting that a balance ..
  34. Naidu R, Har Y, Taib N. Genetic polymorphisms of TP53-binding protein 1 (TP53BP1) gene and association with breast cancer risk. APMIS. 2011;119:460-7 pubmed publisher
    In the present study, we evaluated the association between the TP53BP1 Glu353Asp and T-885G polymorphisms and breast cancer risk as well as with the clinicopathological characteristics of the patients...
  35. Mallette F, Mattiroli F, Cui G, Young L, Hendzel M, Mer G, et al. RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J. 2012;31:1865-78 pubmed publisher
    ..The recruitment of 53BP1 to damaged sites requires the activation of the ubiquitination cascade controlled by the E3 ubiquitin ligases RNF8 ..
  36. Haffty B, Goyal S, Kulkarni D, Green C, Vazquez A, Schiff D, et al. Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT). Int J Radiat Oncol Biol Phys. 2011;80:385-91 pubmed publisher
    b>TP53BP1 is a key component of radiation-induced deoxyribonucleic acid damage repair...
  37. Adams M, Wang B, Xia Z, Morales J, Lu X, Donehower L, et al. 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle. 2005;4:1854-61 pubmed
    b>p53 binding protein 1 (53BP1) participates in the repair of DNA double stranded breaks (DSBs) where it is recruited to or near sites of DNA damage...
  38. Bakkenist C, Kastan M. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 2003;421:499-506 pubmed
  39. Ma H, Hu Z, Zhai X, Wang S, Wang X, Qin J, et al. Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population. Carcinogenesis. 2006;27:766-71 pubmed
    p53-binding protein 1 (P53BP1), a central transducer of DNA-damage signals to p53, is required for both intra-S-phase and G2-M checkpoints, suggesting that these two proteins may work together in the p53-mediated transcriptional ..
  40. Truong T, Sauter W, McKay J, Hosgood H, Gallagher C, Amos C, et al. International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. Carcinogenesis. 2010;31:625-33 pubmed publisher
    ..metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3)...
  41. Tripathi V, Nagarjuna T, Sengupta S. BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. J Cell Biol. 2007;178:9-14 pubmed
    ..We demonstrate that BLM, signal transducer 53BP1, and RAD51 interact during stalled replication...
  42. Botuyan M, Lee J, Ward I, Kim J, Thompson J, Chen J, et al. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 2006;127:1361-73 pubmed
    Histone lysine methylation has been linked to the recruitment of mammalian DNA repair factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs), but how histone recognition is achieved has not been ..
  43. Mailand N, Bekker Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, et al. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell. 2007;131:887-900 pubmed
    ..This is accompanied by an increase in DSB-associated ubiquitylations and followed by accumulation of 53BP1 and BRCA1 repair proteins...
  44. Stewart G, Stankovic T, Byrd P, Wechsler T, Miller E, Huissoon A, et al. RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A. 2007;104:16910-5 pubmed
    ..Sequencing of TP53BP1 and other genes known to regulate ionizing radiation-induced 53BP1 foci formation in this patient failed to ..
  45. Nagelkerke A, van Kuijk S, Sweep F, Nagtegaal I, Hoogerbrugge N, Martens J, et al. Constitutive expression of ?-H2AX has prognostic relevance in triple negative breast cancer. Radiother Oncol. 2011;101:39-45 pubmed publisher
    ..Here, we quantified expression of endogenous ?-H2AX and its downstream factor 53BP1 in a large number of breast cancer cell lines (n=54) and a node-negative breast cancer cohort that had not ..
  46. Fink L, Roell M, Caiazza E, Lerner C, STAMATO T, Hrelia S, et al. 53BP1 contributes to a robust genomic stability in human fibroblasts. Aging (Albany NY). 2011;3:836-45 pubmed
    ..We predicted that 53BP1, a key transducer of the DNA damage response and cell cycle checkpoint control, is highly involved in maintaining ..
  47. Iwabuchi K, Bartel P, Li B, Marraccino R, Fields S. Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci U S A. 1994;91:6098-102 pubmed
    ..Using the yeast two-hybrid system, we identified two previously uncharacterized human proteins, designated 53BP1 and 53BP2, that bind to p53...
  48. Oda H, Hübner M, Beck D, Vermeulen M, Hurwitz J, Spector D, et al. Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol Cell. 2010;40:364-76 pubmed publisher
    ..PR-Set7 is transiently recruited to laser-induced DNA damage sites through its interaction with PCNA, after which 53BP1 is recruited dependent on PR-Set7 catalytic activity...
  49. Lee J, Goodarzi A, Jeggo P, Paull T. 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J. 2010;29:574-85 pubmed publisher
    ..for efficient signalling through MRN and ATM, including the tumour suppressor proteins p53-binding protein 1 (53BP1) and BRCA1...
  50. Wilson K, Stern D. NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway. Cell Cycle. 2008;7:3584-94 pubmed
    NFBD1/MDC1, 53BP1 and BRCA1 are DNA damage checkpoint proteins with twin BRCT domains...
  51. Naruke Y, Nakashima M, Suzuki K, Matsuu Matsuyama M, Shichijo K, Kondo H, et al. Alteration of p53-binding protein 1 expression during skin carcinogenesis: association with genomic instability. Cancer Sci. 2008;99:946-51 pubmed publisher
    ..P53-binding protein 1 (53BP1) belongs to a family of evolutionarily conserved DDR proteins...
  52. Chen K, Hu Z, Wang L, Zhang W, El Naggar A, Sturgis E, et al. Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck. Clin Cancer Res. 2007;13:4300-5 pubmed
    Tumor protein 53-binding protein 1 (TP53BP1) and TP53 interact during TP53-mediated transcriptional activation and during checkpoint activation in response to DNA damage...
  53. Riballo E, Kühne M, Rief N, Doherty A, Smith G, Recio M, et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell. 2004;16:715-24 pubmed
    ..in patients with RS-SCID, function in a common double-strand break (DSB) repair pathway that also requires H2AX, 53BP1, Nbs1, Mre11, and DNA-PK. We show that radiation-induced Artemis hyperphosphorylation is ATM dependent...
  54. Ward I, Minn K, Jorda K, Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem. 2003;278:19579-82 pubmed
    b>53BP1 participates in the cellular response to DNA damage...
  55. Zgheib O, Pataky K, Brugger J, Halazonetis T. An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol Cell Biol. 2009;29:1050-8 pubmed publisher
    b>53BP1, the vertebrate ortholog of the budding yeast Rad9 and fission yeast Crb2/Rhp9 checkpoint proteins, is recruited rapidly to sites of DNA double-strand breaks (DSBs)...
  56. Iwabuchi K, Matsui T, Hashimoto M, Matsumoto Y, Kurihara T, Date T. Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1. Biochem Biophys Res Commun. 2008;376:509-13 pubmed publisher
    b>53BP1 plays important roles in checkpoint signaling and repair for DNA double-strand breaks...