TOMM7

Summary

Gene Symbol: TOMM7
Description: translocase of outer mitochondrial membrane 7
Alias: TOM7, mitochondrial import receptor subunit TOM7 homolog, 6.2 kd protein, translocase of outer membrane 7 kDa subunit homolog, translocase of outer mitochondrial membrane 7 homolog
Species: human
Products:     TOMM7

Top Publications

  1. Lee J. Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted human glioma M059J cells. DNA Seq. 1999;10:195-8 pubmed
    ..5 times). Therefore, this result suggests that DNA-PK may negatively regulate the transcriptional level of this gene in M059K cells upon UV damage (50 J/m2), associated with cell toxicity. ..
  2. Gadir N, Haim Vilmovsky L, Kraut Cohen J, Gerst J. Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiae. RNA. 2011;17:1551-65 pubmed publisher
    ..the specific determinants of ATP2 and OXA1 mRNA localization and found a mutual dependency on the 3' UTR, Puf3, Tom7, and Tom70, but not Tom20, for localization...
  3. Sekine S, Wang C, Sideris D, Bunker E, Zhang Z, Youle R. Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1. Mol Cell. 2019;73:1028-1043.e5 pubmed publisher
    ..at the outer mitochondrial membrane, either by mutagenesis of this negatively charged motif or by deletion of Tom7, is imported into depolarized mitochondria and cleaved by the OMA1 protease...
  4. Ning J, Junyi T, Chang M, Yueting W, Jingyan Z, Jin Z, et al. TOM7 silencing exacerbates focal cerebral ischemia injury in rat by targeting PINK1/Beclin1-mediated autophagy. Behav Brain Res. 2019;360:113-119 pubmed publisher
    ..b>TOM7, which is a component of the protein translocase of the outer mitochondrial membrane (TOM) complex, may modulate ..
  5. Wojtkowska M, Buczek D, Stobienia O, Karachitos A, Antoniewicz M, Slocinska M, et al. The TOM Complex of Amoebozoans: the Cases of the Amoeba Acanthamoeba castellanii and the Slime Mold Dictyostelium discoideum. Protist. 2015;166:349-62 pubmed publisher
    ..Our results confirm the presence of Tom70, Tom40 and Tom7 in the A. castellanii and D. discoideum TOM complex, while the presence of Tom22 and Tom20 is less supported...
  6. Wang R, Li J, Zhao Y, Li Y, Yin L. Investigating the therapeutic potential and mechanism of curcumin in breast cancer based on RNA sequencing and bioinformatics analysis. Breast Cancer. 2018;25:206-212 pubmed publisher
    ..PPI network was constructed, and the top DEGs were FOS, VIM, FGF2, MAPK1, SPARC, TOMM7, PSMB10, TCEB2, SOCS1, COL4A1, UQCR11, SERPINE1, and ISG15...
  7. Mani J, Meisinger C, Schneider A. Peeping at TOMs-Diverse Entry Gates to Mitochondria Provide Insights into the Evolution of Eukaryotes. Mol Biol Evol. 2016;33:337-51 pubmed publisher
    ..b>Tom7 is found in representatives of all supergroups except the Excavates...
  8. Humphries A, Streimann I, Stojanovski D, Johnston A, Yano M, Hoogenraad N, et al. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005;280:11535-43 pubmed
    ..Nevertheless, we show that Tom40 assembly is reduced in mitochondria depleted of human Sam50. These findings are discussed in context with current models from fungal studies. ..
  9. Kato H, Mihara K. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Biochem Biophys Res Commun. 2008;369:958-63 pubmed publisher
    ..comprises import receptors Tom70, Tom20, and Tom22, import channel Tom40, and small Tom proteins Tom5, Tom6, and Tom7, which regulate TOM complex assembly...

More Information

Publications12

  1. van Dooren G, Yeoh L, Striepen B, McFadden G. The Import of Proteins into the Mitochondrion of Toxoplasma gondii. J Biol Chem. 2016;291:19335-50 pubmed publisher
    ..We also identify and characterize a T. gondii homologue of Tom7 (TgTom7) that is important for parasite survival and mitochondrial protein import...
  2. Johnston A, Hoogenraad J, Dougan D, Truscott K, Yano M, Mori M, et al. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. J Biol Chem. 2002;277:42197-204 pubmed
    b>Tom7 is a component of the translocase of the outer mitochondrial membrane (TOM) and assembles into a general import pore complex that translocates preproteins into mitochondria...
  3. Bausewein T, Mills D, Langer J, Nitschke B, Nussberger S, Kuhlbrandt W. Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell. 2017;170:693-700.e7 pubmed publisher
    ..Each Tom40 pore is surrounded by the transmembrane segments of the ?-helical subunits Tom5, Tom6, and Tom7. Tom22, the central preprotein receptor, connects the two Tom40 pores at the dimer interface...