TOMM40

Summary

Gene Symbol: TOMM40
Description: translocase of outer mitochondrial membrane 40 homolog (yeast)
Alias: C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40, mitochondrial import receptor subunit TOM40 homolog, mitochondrial outer membrane protein, p38.5, protein Haymaker, translocase of outer membrane 40 kDa subunit homolog
Species: human

Top Publications

  1. pmc The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death
    Syed Mohammad Moin
    Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India
    J Biol Chem 282:21124-33. 2007
  2. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
  3. doi Genetic variation in APOE cluster region and Alzheimer's disease risk
    Sebastian Cervantes
    Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Neurobiol Aging 32:2107.e7-17. 2011
  4. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
  5. pmc Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA
    PLoS ONE 4:e6501. 2009
  6. pmc Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort
    S Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street, R2 E124, Indianapolis, IN 46202, USA
    Neurology 76:69-79. 2011
  7. pmc A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
    A D Roses
    Department of Medicine, Duke University, Durham, NC 27708 0120, USA
    Pharmacogenomics J 10:375-84. 2010
  8. pmc Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease
    Carlos Cruchaga
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Neurol 68:1013-9. 2011
  9. pmc Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 12:123. 2011
  10. pmc The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype
    Sterling C Johnson
    Wisconsin Alzheimer s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Alzheimers Dement 7:456-65. 2011

Scientific Experts

Detail Information

Publications134 found, 100 shown here

  1. pmc The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death
    Syed Mohammad Moin
    Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India
    J Biol Chem 282:21124-33. 2007
    ..VDAC is a critical mitochondrial outer membrane protein, and its overexpression results in apoptosis...
  2. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
    ..APOE epsilon4 genotype does not predict CSF apoE levels. Three SNPs within the TOMM40 gene, one APOE promoter SNP and two SNPs within distal APOE enhancer elements (ME1 and BCR) predict CSF apoE ..
  3. doi Genetic variation in APOE cluster region and Alzheimer's disease risk
    Sebastian Cervantes
    Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Neurobiol Aging 32:2107.e7-17. 2011
    ..results of promoter and regulatory regions of APOE cluster genes (APOE, APOC1, APOC4, APOC2, and TOMM40) in Alzheimer's disease (AD) risk as well as in the progression from mild cognitive impairment (MCI) to AD...
  4. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  5. pmc Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA
    PLoS ONE 4:e6501. 2009
    ..With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown...
  6. pmc Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort
    S Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street, R2 E124, Indianapolis, IN 46202, USA
    Neurology 76:69-79. 2011
    ..We report a genome-wide association study (GWAS) of CSF biomarkers (Aβ1-42, t-tau, p-tau181p, p-tau181p/Aβ1-42, and t-tau/Aβ1-42)...
  7. pmc A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
    A D Roses
    Department of Medicine, Duke University, Durham, NC 27708 0120, USA
    Pharmacogenomics J 10:375-84. 2010
    ..a polymorphic poly-T variant, rs10524523, in the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene that provides greatly increased precision in the estimation of age of LOAD onset for APOE ɛ3 carriers...
  8. pmc Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease
    Carlos Cruchaga
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Neurol 68:1013-9. 2011
    ..The linkage disequilibrium pattern around the APOE gene has made it difficult to determine whether all the association signal is derived from APOE or whether there is an independent signal from a nearby gene...
  9. pmc Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 12:123. 2011
    ....
  10. pmc The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype
    Sterling C Johnson
    Wisconsin Alzheimer s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Alzheimers Dement 7:456-65. 2011
    ..poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier ..
  11. pmc Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
    ..Here, we report single-locus and epistasis SNP effects on TC and HDL-C using the Framingham Heart Study (FHS) data...
  12. pmc Genome-wide scan of copy number variation in late-onset Alzheimer's disease
    Erin L Heinzen
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA
    J Alzheimers Dis 19:69-77. 2010
    ..In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation...
  13. pmc TOMM40 poly-T repeat lengths, age of onset and psychosis risk in Alzheimer disease
    Su Hee Chu
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA
    Neurobiol Aging 32:2328.e1-9. 2011
    ..region in a small sample of LOAD subjects identified a variable length poly-T repeat sequence in the nearby gene, TOMM40, which may affect age of onset...
  14. ncbi Dissection of the mitochondrial import and assembly pathway for human Tom40
    Adam D Humphries
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    J Biol Chem 280:11535-43. 2005
    b>Tom40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM complex), essential for protein import into mitochondria...
  15. doi Examination of the current top candidate genes for AD in a genome-wide association study
    T M Feulner
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TUM, Munich, Germany
    Mol Psychiatry 15:756-66. 2010
    ..Finally, our data confirm that GWAS, regardless of the platform, are valuable for the identification of genetic variants associated with AD...
  16. pmc Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    Alexander P Reiner
    University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
    Am J Hum Genet 82:1193-201. 2008
    ....
  17. ncbi Inactivation of the Neurospora crassa mitochondrial outer membrane protein TOM70 by repeat-induced point mutation (RIP) causes defects in mitochondrial protein import and morphology
    L I Grad
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Curr Genet 36:137-46. 1999
    ..The presence of tetratricopeptide repeats (TPRs) in the TOM70 sequence and the enlarged shape of mitochondria lacking TOM70 raise the possibility that the protein also plays a role in the maintenance of mitochondrial morphology...
  18. ncbi Protein sorting between the outer and inner mitochondrial membranes: submitochondrial localization of cytochrome c1 whose presequence is replaced by the amino-terminal region of a 70 kDa outer membrane protein
    M Nakai
    Department of Biology, Faculty of Science, Osaka University
    J Biochem 106:181-7. 1989
    The amino-terminal region of a 70 kDa mitochondrial outer membrane protein of yeast and the presequence of cytochrome c1, an inner membrane protein exposed to the intermembrane space, are thought to be responsible for localizing the ..
  19. pmc Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus
    Vilius Stribinskis
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Mol Cell Biol 25:6546-58. 2005
    ..The ability of RPM2 alleles to suppress tom40-3, a temperature-sensitive mutant of a component of the mitochondrial import apparatus, correlates with their ..
  20. pmc The essentials of protein import in the degenerate mitochondrion of Entamoeba histolytica
    Pavel Dolezal
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, Victoria, Australia
    PLoS Pathog 6:e1000812. 2010
    ..membrane-located components of the protein import machinery that includes the outer membrane translocation channel Tom40 and membrane assembly protein Sam50. Using in vitro and in vivo systems we show that E...
  21. ncbi Import and assembly of Neurospora crassa Tom40 into mitochondria of Trypanosoma brucei in vivo
    Minu Chaudhuri
    Department of Microbiology, Meharry Medical College, Nashville, TN 37208, USA
    Curr Genet 44:85-94. 2003
    The TOM complex (translocase of the mitochondrial outer membrane) is a dynamic, multisubunit protein complex. Tom40 is the major component of the complex and forms the preprotein conducting pore...
  22. pmc Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity
    Helena Castro
    IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
    PLoS ONE 5:e12607. 2010
    ..subcellular localization and membrane topology, which revealed that LiTXN3 is a tail-anchored (TA) mitochondrial outer membrane protein presenting, as characteristic of TA proteins, its N-terminal end (containing the redox-active ..
  23. doi N-terminal region of Mannheimia haemolytica leukotoxin serves as a mitochondrial targeting signal in mammalian cells
    Dagmara I Kisiela
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Cell Microbiol 12:976-87. 2010
    ..By immunoprecipitation we demonstrate that LktA interacts with the Tom22 and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin ..
  24. doi Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane
    Thomas Becker
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, 79104 Freiburg, Germany
    J Mol Biol 405:113-24. 2011
    ..of the outer mitochondrial membrane (TOM complex) involves the assembly of the central β-barrel forming protein Tom40 with six different subunits that are embedded in the membrane via α-helical transmembrane segments...
  25. ncbi Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10
    Chris Meisinger
    Institut für Biochemie und Molekularbiologie and the Fakultät für Biologie, Universitat Freiburg, 79104 Freiburg
    J Biol Chem 281:22819-26. 2006
    ..proteins, Mdm10 and the SAM(holo) complex play a selective role in beta-barrel biogenesis by promoting assembly of Tom40 but not of porin...
  26. pmc Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip
    Philippa J Talmud
    Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
    Am J Hum Genet 85:628-42. 2009
    ..associated with LDL cholesterol and apolipoprotein B were located in LDLR, PCSK9, APOB, CELSR2, HMGCR, CETP, the TOMM40-APOE-C1-C2-C4 cluster, and the APOA5-A4-C3-A1 cluster; SNPs associated with HDL cholesterol and apolipoprotein AI ..
  27. ncbi Relationship between the peptide-sensitive channel and the mitochondrial outer membrane protein translocation machinery
    P Juin
    Service de Neurobiologie Physico Chimique, Centre National de la Recherche Scientifique, , Institut de Biologie Physico Chimique, 13 rue P et M Curie, 75005 Paris, France
    J Biol Chem 272:6044-50. 1997
    ..Taken together, the present data reinforce the hypothesis that the PSC is the pore responsible for the translocation of protein through the outer membrane...
  28. pmc In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death
    Heftsi Azoulay-Zohar
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochem J 377:347-55. 2004
    ..Our studies relying on the purified mitochondrial outer membrane protein VDAC (voltage-dependent anion channel), isolated mitochondria or cells in culture suggested that ..
  29. doi Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of alpha-helical outer membrane proteins
    Nicolas Thornton
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, D 79104 Freiburg, Germany
    J Mol Biol 396:540-9. 2010
    ..complex is required for the assembly of precursors of the TOM complex, including not only the beta-barrel protein Tom40 but also a subset of alpha-helical subunits...
  30. pmc Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa
    Jeremy G Wideman
    Department of Biological Sciences, University of Alberta, Alberta, Canada
    Mol Biol Cell 21:1725-36. 2010
    ..functions including mitochondrial distribution and morphology, assembly of beta-barrel proteins such as Tom40 and porin, association of mitochondria and endoplasmic reticulum, and maintaining lipid composition of ..
  31. doi Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A
    Romain Cartoni
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Brain 133:1460-9. 2010
    ..Mitofusin 2 encodes a mitochondrial outer membrane protein that participates in mitochondrial fusion in mammalian cells...
  32. pmc Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis
    Sabine Weller
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 76:987-1007. 2005
    ..we made a chimeric protein (PEX26-Mito) with PEX26 as its N-terminus and the targeting segment of a mitochondrial outer membrane protein (OMP25) at its C-terminus...
  33. pmc Functional cooperation of mitochondrial protein import receptors in yeast
    L Ramage
    Biocenter, University of Basel, Switzerland
    EMBO J 12:4115-23. 1993
    We have identified a 20 kDa yeast mitochondrial outer membrane protein (termed MAS20) which appears to function as a protein import receptor...
  34. pmc Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation
    Marie Anne Robin
    Department of Animal Biology, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 277:40583-93. 2002
    ..S129A mutation resulted in lower affinity for binding to cytoplasmic Hsp70, mitochondrial translocases (TOM40 and TIM44) and reduced mitochondrial import...
  35. pmc Kingdoms Protozoa and Chromista and the eozoan root of the eukaryotic tree
    Thomas Cavalier-Smith
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Biol Lett 6:342-5. 2010
    ..The bacteria-like absence of mitochondrial outer-membrane channel Tom40 and DNA replication origin-recognition complexes from trypanosomatid Euglenozoa roots the eukaryotic tree between ..
  36. ncbi Identification and characterization of Xenopus OMP25
    Masafumi Inui
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8654, Japan
    Dev Growth Differ 46:405-12. 2004
    This study describes the isolation of mitochondrial outer membrane protein 25 (OMP25) from Xenopus laevis and an analysis of its role in early development. X...
  37. pmc ABA, porphyrins and plant TSPO-related protein
    Damien Guillaumot
    Institut des Sciences de la Vie, Molecular Physiology Group FYMO, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    Plant Signal Behav 4:1087-90. 2009
    ..of mammalian 18-kDa translocator protein (at least for the mostly studied isoform, 18-kDa TSPO), a mitochondrial outer membrane protein (reviewed in ref. 2)...
  38. ncbi Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane
    K Saeki
    Institute of Life Science, Kurume University, 2432 3, Aikawa machi, Kurume 839 0861, Japan
    J Biol Chem 275:31996-2002. 2000
    A mitochondrial outer membrane protein of approximately 22 kDa (1C9-2) was purified from Vero cells assessing immunoreactivity with a monoclonal antibody, and the cDNA was cloned based on the partial amino acid sequence of the trypsin-..
  39. pmc Genetic variation at a single locus and age of onset for Alzheimer's disease
    Michael W Lutz
    Deane Drug Discovery Institute, Duke University, Durham, NC, USA
    Alzheimers Dement 6:125-31. 2010
    ..finding discussed here is that a variable-length, deoxythymidine homopolymer (poly-T) within intron 6 of the TOMM40 gene is associated with the age of onset of LOAD [Roses AD, Lutz MW, Amrine-Madsen H, Saunders AM, Crenshaw DG, ..
  40. pmc Ian4 is required for mitochondrial integrity and T cell survival
    Malini Pandarpurkar
    Department of Medicine and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 218, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 100:10382-7. 2003
    ..These proteins localize to the outer mitochondrial membrane. Ian4, a mitochondrial outer membrane protein with GTP-binding activity, is normally present in thymocytes, T cells, and B cells...
  41. pmc Structural requirements of Tom40 for assembly into preexisting TOM complexes of mitochondria
    D Rapaport
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Mol Biol Cell 12:1189-98. 2001
    b>Tom40 is the major subunit of the translocase of the outer mitochondrial membrane (the TOM complex)...
  42. pmc Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex
    Thomas Becker
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, Freiburg, Germany
    Mol Biol Cell 21:3106-13. 2010
    The preprotein translocase of the outer mitochondrial membrane (TOM) consists of a central β-barrel channel, Tom40, and six proteins with α-helical transmembrane segments...
  43. ncbi Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors
    Thomas Becker
    Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universitat Freiburg, D 79104 Freiburg, Germany
    J Biol Chem 283:120-7. 2008
    ..The channel-forming beta-barrel protein Tom40 is targeted to mitochondria via Tom receptors and inserted into the outer membrane by the sorting and assembly ..
  44. ncbi Preprotein translocase of the outer mitochondrial membrane: reconstituted Tom40 forms a characteristic TOM pore
    Lars Becker
    Biophysik, Universitat Osnabruck, FB Biologie Chemie, D 49034 Osnabrück, Germany
    J Mol Biol 353:1011-20. 2005
    b>Tom40 is the central pore-forming component of the translocase of the outer mitochondrial membrane (TOM complex)...
  45. pmc Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors
    C Meisinger
    , , Germany
    Mol Cell Biol 21:2337-48. 2001
    ..400-kDa (400 K) general import pore (GIP) complex that includes the central receptor Tom22, the channel Tom40, and the three small Tom proteins Tom7, Tom6, and Tom5...
  46. pmc Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex
    P J Dekker
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, D 79104 Freiburg, Germany
    Mol Cell Biol 18:6515-24. 1998
    ..We have analyzed the molecular architecture of the Tom machinery. The receptor Tom22 stably associates with Tom40, the main component of the GIP, in a complex with a molecular weight of approximately 400,000 ( approximately 400K)..
  47. doi Biogenesis of the mitochondrial Tom40 channel in skeletal muscle from aged animals and its adaptability to chronic contractile activity
    Anna Maria Joseph
    School of Kinesiology and Health Science, York Univesity, Toronto, ON, Canada
    Am J Physiol Cell Physiol 298:C1308-14. 2010
    ..b>Tom40 assembly into the translocases of the outer membrane (TOM complex) was measured in subsarcolemmal mitochondria ..
  48. pmc Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40
    Koji Yamano
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 285:41222-31. 2010
    barrel membrane proteins in the mitochondrial outer membrane use the TOM40 complex to enter mitochondria and then the TOB/SAM complex to be assembled into the outer membrane...
  49. ncbi Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase
    Jun Ya Kinoshita
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biochem 141:897-906. 2007
    Newly synthesized precursors are transported into mitochondria through an outer membrane translocase, TOM. Tom40, a central pore-forming component, interacts directly with precursors to help them translocate across the outer membrane...
  50. doi Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population
    Ardeshir Omoumi
    Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Neurobiol Aging 35:936.e5-936.e12. 2014
    ..no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3865444 (CD33) with late-onset AD that were robust to adjustment with age and ..
  51. doi The single mitochondrial porin of Trypanosoma brucei is the main metabolite transporter in the outer mitochondrial membrane
    Mascha Pusnik
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Mol Biol Evol 26:671-80. 2009
    ..conserved metabolite transporter VDAC (voltage dependent anion channel) and the conserved protein import channel Tom40. Bioinformatic searches of the Trypanosoma brucei genome for either VDAC or Tom40 identified a single open reading ..
  52. pmc Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40
    Anton Kuzmenko
    University of Tartu, Institute of Technology, Tartu, Estonia
    Sci Rep 1:195. 2011
    b>Tom40 is an integral protein of the mitochondrial outer membrane, which as the central component of the Translocase of the Outer Membrane (TOM) complex forms a channel for protein import...
  53. pmc In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work
    Takuya Shiota
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 108:15179-83. 2011
    ..Here we analyze the interactions of Tom22, a multifunctional subunit of the outer membrane translocator TOM40 complex, with other translocator subunits such as Tom20, Tom40, and Tim50 and with substrate precursor proteins at ..
  54. ncbi Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery
    Nils Wiedemann
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, Hermann Herder Strasse 7, Germany
    J Mol Biol 327:465-74. 2003
    ..When the general import pore (GIP)-protein Tom40 is blocked, the import of cytochrome c is moderately affected...
  55. ncbi N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, A 1030, Austria
    J Mol Biol 317:541-57. 2002
    ..4, kinase interacting proteins KIP1/KIP2, protozoan flagellar proteins, homologues of mitochondrial translocase TOM40, of the neuronal calcium sensor NCS-1 and of the cytochrome c-type heme lyase CCHL...
  56. pmc An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease
    Allen D Roses
    Department of Neurobiology and Neurology and the Deane Drug Discovery Institute, Duke University, Durham, North Carolina 27708, USA
    Arch Neurol 67:536-41. 2010
    I coauthored a recently published research article describing a variable length, poly-T polymorphism in the TOMM40 gene, adjacent to apolipoprotein E (APOE) on chromosome 19, that accounts for the age at onset distribution for a complex ..
  57. pmc Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities
    Adam C Naj
    Dr John T Macdonald Foundation Department of Human Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS Genet 6:e1001130. 2010
    ..This finding is noteworthy, as MTHFD1L may play a role in the generation of methionine from homocysteine and influence homocysteine-related pathways and as levels of homocysteine are a significant risk factor for LOAD development...
  58. pmc Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to β-barrel protein assembly and maintenance of mitochondrial morphology
    Jeremy G Wideman
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e71837. 2013
    ..Dimer formation is required for efficient assembly of Tom40 into the TOM complex. However, no effects are seen on porin assembly or mitochondrial morphology...
  59. pmc The voltage-dependent anion channel, a major component of the tRNA import machinery in plant mitochondria
    Thalia Salinas
    Institut de Biologie Moleculaire des Plantes, Unité Propre de Recherche 2357, Conventionné avec l Université Louis Pasteur Strasbourg1, Centre National de la Recherche Scientifique, 67084 Strasbourg Cedex, France
    Proc Natl Acad Sci U S A 103:18362-7. 2006
    ..two major components from the TOM (translocase of the outer mitochondrial membrane) complex, namely TOM20 and TOM40, are important for tRNA binding at the surface of mitochondria, suggesting that they are also involved in tRNA ..
  60. ncbi Crystallization and preliminary crystallographic analysis of rat monoamine oxidase A complexed with clorgyline
    Jichun Ma
    Institute for Protein Research, Osaka University, Japan
    Acta Crystallogr D Biol Crystallogr 60:317-9. 2004
    ..Diffraction data were collected to 3.2 A resolution. The crystal belongs to the space group P4(3)2(1)2, with unit-cell parameters a = b = 158.2, c = 258.4 A...
  61. ncbi Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway
    Nils Wiedemann
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, D 79104 Freiburg, Germany
    J Biol Chem 279:18188-94. 2004
    b>Tom40 forms the central channel of the preprotein translocase of the mitochondrial outer membrane (TOM complex)...
  62. ncbi Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability
    Dusanka Milenkovic
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, D 79104 Freiburg, Germany
    J Biol Chem 279:22781-5. 2004
    ..Here we report the identification of Sam35, the first peripheral mitochondrial outer membrane protein that is essential for cell viability...
  63. doi TOMM40 poly-T variants and cerebrospinal fluid amyloid beta levels in the elderly
    Nunzio Pomara
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Bldg 35, Orangeburg, NY 10962, USA
    Neurochem Res 36:1124-8. 2011
    A variable poly-T polymorphism in the TOMM40 gene, which is in linkage disequilibrium with APOE, was recently implicated with increased risk and earlier onset age for late-onset Alzheimer's disease in APOE ε3 carriers...
  64. pmc Casein kinase 2 is essential for mitophagy
    Tomotake Kanki
    Laboratory of Biosignaling, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510
    EMBO Rep 14:788-94. 2013
    ..When mitophagy is induced in yeast, the mitochondrial outer membrane protein Atg32 is phosphorylated, interacts with the adaptor protein Atg11 and is recruited into the vacuole ..
  65. pmc Estradiol and tamoxifen regulate NRF-1 and mitochondrial function in mouse mammary gland and uterus
    Margarita M Ivanova
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, Texas 77204, USA
    J Mol Endocrinol 51:233-46. 2013
    ..E2 increased mt outer membrane Tomm40 protein levels in MG and uterus whereas 4-OHT increased Tomm40 only in uterus...
  66. ncbi Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest
    Steven J Greco
    Neurotez, Inc 991 Highway 22, Suite 200A Bridgewater, New Jersey 08807, USA
    Curr Alzheimer Res 9:1168-73. 2012
    Recent studies have shown that the translocase of outer mitochondrial membrane 40 homolog (TOMM40) contains a polymorphic poly-T variant, the long variant of which is associated with an increase in AD incidence among APOE 3 carriers...
  67. pmc Association study of candidate gene polymorphisms with amnestic mild cognitive impairment in a Chinese population
    Xiaoyan Liu
    School of Clinical Medicine, Southeast University, Nanjing, China
    PLoS ONE 7:e41198. 2012
    ..The distributions of SNPs relating to the amyloid cascade hypothesis (TOMM40 rs157581 G and TOMM40 rs2075650 G), to the cholesterol metabolism hypothesis (ApoE rs429358 C, LDLR rs11668477 G ..
  68. pmc Genome-wide association study of Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Transl Psychiatry 2:e117. 2012
    ..43. This is a potential candidate gene for AD as this is expressed in the brain and is involved in lipid metabolism. These findings need to be confirmed in additional samples...
  69. pmc An essential novel component of the noncanonical mitochondrial outer membrane protein import system of trypanosomatids
    Mascha Pusnik
    Department of Chemistry and Biochemistry, University of Bern, CH 3012 Bern, Switzerland
    Mol Biol Cell 23:3420-8. 2012
    The mitochondrial outer membrane protein Tom40 is the general entry gate for imported proteins in essentially all eukaryotes...
  70. ncbi Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls
    Tih Shih Lee
    Department of Psychiatry and Behavioral Science, Duke University Medical School, DUMC Box 3950, Durham, NC 27710, USA Duke NUS Graduate Medical School, Singapore
    J Psychiatr Res 46:828-30. 2012
    Translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene has been reported in several GWAS to be associated with Alzheimer disease (AD)...
  71. pmc Genome-wide association analysis of age-at-onset in Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Psychiatry 17:1340-6. 2012
    ..These findings need to be confirmed in additional well-powered samples...
  72. ncbi Membrane-embedded C-terminal segment of rat mitochondrial TOM40 constitutes protein-conducting pore with enriched beta-structure
    Hiroyuki Suzuki
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 279:50619-29. 2004
    b>TOM40 is the central component of the preprotein translocase of the mitochondrial outer membrane (TOM complex)...
  73. doi The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast
    Thibaud T Renault
    CNRS, IBGC, UMR5095, F 33000 Bordeaux, France
    FEBS Lett 586:116-21. 2012
    ..These data suggest that the interaction with the cytosolic domain of Tom22 helps Bax to acquire a conformation able to interact with the outer mitochondrial membrane...
  74. pmc Functions of the small proteins in the TOM complex of Neurospora crasssa
    E Laura Sherman
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Mol Biol Cell 16:4172-82. 2005
    ..Newly imported Tom40 was readily assembled into the TOM complex in mitochondria lacking any of the small Tom proteins.
  75. ncbi Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
    Latha Devi
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:9057-68. 2006
    ..APP formed stable approximately 480 kDa complexes with the translocase of the outer mitochondrial membrane 40 (TOM40) import channel and a super complex of approximately 620 kDa with both mitochondrial TOM40 and the translocase of ..
  76. doi Cu,Zn-superoxide dismutase is necessary for proper function of VDAC in Saccharomyces cerevisiae cells
    Andonis Karachitos
    Laboratory of Bioenergetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Umultowska 89, 61 614 Poznan, Poland
    FEBS Lett 583:449-55. 2009
    ..in VDAC levels as well as in levels of protein crucial for VDAC import into mitochondria, namely Tob55/Sam50 and Tom40. The observed alterations may result in mitochondriopathy and subsequently in the shortening of the replicative ..
  77. pmc Biogenesis of Tom40, core component of the TOM complex of mitochondria
    D Rapaport
    Institut fur Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München, 80336 Munchen, Germany
    J Cell Biol 146:321-31. 1999
    b>Tom40 is an essential component of the preprotein translocase of the mitochondrial outer membrane (TOM complex) in which it constitutes the core element of the protein conducting pore. We have investigated the biogenesis of Tom40...
  78. ncbi Effect of mutations in Tom40 on stability of the translocase of the outer mitochondrial membrane (TOM) complex, assembly of Tom40, and import of mitochondrial preproteins
    E Laura Sherman
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    J Biol Chem 281:22554-65. 2006
    ..b>Tom40 is the major component of the complex and is essential for cell viability...
  79. doi Functional refolding and characterization of two Tom40 isoforms from human mitochondria
    Frauke Mager
    Biophysics Department, Institute of Biology, University of Stuttgart, Germany
    J Membr Biol 242:11-21. 2011
    b>Tom40 proteins represent an essential class of molecules which facilitate translocation of unfolded proteins from the cytosol into the mitochondrial intermembrane space...
  80. pmc NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL
    Thomas J Malia
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 46:514-25. 2007
    ..Our characterization of the VDAC/Bcl-xL complex offers initial structural insight into the role of antiapoptotic Bcl-xL in regulating apoptotic events in the mitochondrial outer membrane...
  81. doi LILBID-mass spectrometry of the mitochondrial preprotein translocase TOM
    Frauke Mager
    Biophysics Department, Institute of Biology, University of Stuttgart, Pfaffenwaldring 57, D 70550 Stuttgart, Germany
    J Phys Condens Matter 22:454132. 2010
    ..purified at high pH, we demonstrate that a TOM core complex of Neurospora crassa is composed of at least two Tom40 and Tom22 molecules, respectively, and more than five small Tom subunits between 5.5 and 6.4 kDa...
  82. pmc Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria
    Noriaki Kitamura
    Cancer Medicine and Biophysics Division, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 6:e16060. 2011
    ..Reactive oxygen species (ROS) scavengers completely inhibited MALM. A mitochondrial outer membrane protein NIX interacted with Mieap in a ROS-dependent manner via the BH3 domain of NIX and the coiled-coil ..
  83. pmc Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage
    Ulziibat Shirendeb
    Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Hum Mol Genet 20:1438-55. 2011
    ..dynamin-related protein 1), Fis1 (fission 1), Mfn1 (mitofusin 1), Mfn2 (mitofusin 2), Opa1 (optric atrophy 1), Tomm40 (translocase of outermembrane 40) and CypD (cyclophilin D) in grade III and grade IV HD patients and controls...
  84. pmc A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans
    Brian P Head
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Mol Biol Cell 22:831-41. 2011
    ..One of these is the novel mitochondrial outer membrane protein MOMA-1...
  85. ncbi Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase
    S van Wilpe
    Institute for Molecular Cell Biology, BioCentrum Amsterdam, The Netherlands
    Nature 401:485-9. 1999
    ..both its cytosolic domain and its intermembrane space domain and is stably associated with the channel protein Tom40 (refs 11-13)...
  86. ncbi Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1
    E M Freitas
    Centre for Molecular Immunology and Instrumentation, University of Westem Australia, Nedlands
    DNA Seq 9:89-100. 1998
    Through the sequencing of a 42kb cosmid clone we describe a new gene, designated PEREC1, located approximately 1.5kb centromeric of the human apolipoprotein (APO) E-C2 cluster...
  87. ncbi Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae
    D Rapaport
    Institut fur Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München, Goethestrabetae 33, 80336 Munchen, Germany
    J Biol Chem 273:20150-5. 1998
    ..It is imported into the outer membrane in a receptor-dependent manner. Fzo1p is part of a larger protein complex of 800 kDa, and presumably is the first identified component of the yeast mitochondrial fusion machinery...
  88. pmc Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability
    A E Hobbs
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 152:401-10. 2001
    ..We propose that Mmm1p is part of a connection between the mitochondrial outer and inner membranes, anchoring mitochondrial DNA nucleoids in the matrix...
  89. pmc Improving the resistance of a eukaryotic β-barrel protein to thermal and chemical perturbations
    Dennis Gessmann
    Biophysics Department, Institute of Biology, University of Stuttgart, Pfaffenwaldring 57, 70550 Stuttgart, Germany
    J Mol Biol 413:150-61. 2011
    ..Our results show that the use of empirical energy functions to model the apparent stability of β-barrel membrane proteins may be a useful tool in the field of nanopore bioengineering...
  90. ncbi Proteomic analysis of isolated membrane fractions from superinvasive cancer cells
    Paul Dowling
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Biochim Biophys Acta 1774:93-101. 2007
    ..anion channel 1, voltage dependent anion channel 2, ER-60 protein, MHC class II antigen DR52, Beta actin, TOMM40 protein, Enolase 1, Prohibitin, Guanine nucleotide-binding protein, Annexin II, Heat shock 70 kDa protein, ..
  91. pmc Conserved roles of Sam50 and metaxins in VDAC biogenesis
    Vera Kozjak-Pavlovic
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Chariteplatz 1, D 10117, Berlin, Germany
    EMBO Rep 8:576-82. 2007
    ..2-depleted mitochondria had reduced levels of metaxin 1 and were deficient in import and assembly of VDAC and Tom40, but not of three matrix-targeted precursors...
  92. ncbi Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization
    Fatou Nsoure Obame
    INSERM U841, Equipe 3, Facultéde Médecine de Paris XII, 8 rue du General Sarrail, F 94010, Creteil, France
    J Pharmacol Exp Ther 323:336-45. 2007
    ..ischemia-reperfusion injury and several ligands of the peripheral benzodiazepine receptor (PBR), a mitochondrial outer membrane protein possibly associated with PTP, have been demonstrated as potent cardioprotective agents...
  93. pmc HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis
    Goang Won Cho
    Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, Seoul 137 040, Korea
    BMC Cell Biol 8:50. 2007
    ..The Human cervical cancer oncogene (HCCR-1) has been isolated as a human oncoprotein, and has shown strong tumorigenic features. Its potential role in tumorigenesis may result from a negative regulation of the p53 tumor suppressor gene...
  94. ncbi Intramitochondrial protein sorting. Isolation and characterization of the yeast MSP1 gene which belongs to a novel family of putative ATPases
    M Nakai
    Department of Chemistry, Faculty of Science, Nagoya University, Japan
    J Biol Chem 268:24262-9. 1993
    ..of the presequence of yeast cytochrome c1 by the amino-terminal 61 residues of MAS70, a yeast mitochondrial outer membrane protein, resulted in exclusive localization of the fusion protein (termed the 61-mC1 protein) to the outer ..
  95. doi Mutation of a mitochondrial outer membrane protein affects chloroplast lipid biosynthesis
    Changcheng Xu
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    Plant J 54:163-75. 2008
    ..These results likely implicate the production of reactive oxygen in the regulation of the alternative galactoglycerolipid pathway in plants...
  96. pmc Genetic and biochemical characterization of ISP6, a small mitochondrial outer membrane protein associated with the protein translocation complex
    C K Kassenbrock
    Department of Biochemistry and Biophysics, University of North Carolina, School of Medicine, Chapel Hill 27599 7260
    EMBO J 12:3023-34. 1993
    ..Immunoprecipitation of the gene product, ISP42p, from mitochondria solubilized under mild conditions reveals a multi-protein complex containing ISP6p and ISP42p...
  97. pmc Dynamics of the preprotein translocation channel of the outer membrane of mitochondria
    Melissa Poynor
    Abteilung Biophysik, Biologisches Institut, Universitat Stuttgart, Stuttgart, Germany
    Biophys J 95:1511-22. 2008
    ..We have purified TOM core complex and Tom40, the main pore forming subunit, from mitochondria of the filamentous fungus Neurospora crassa and incorporated ..
  98. pmc Origin of mitochondria by intracellular enslavement of a photosynthetic purple bacterium
    Thomas Cavalier-Smith
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Proc Biol Sci 273:1943-52. 2006
    ..the periplasmic space via pre-existing beta-barrel proteins in the bacterial outer membrane that later became Tom40, and inserted into the inner membrane probably helped by a pre-existing inner membrane protein, thereby ..
  99. pmc Role of the negative charges in the cytosolic domain of TOM22 in the import of precursor proteins into mitochondria
    F E Nargang
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Mol Cell Biol 18:3173-81. 1998
    TOM22 is an essential mitochondrial outer membrane protein required for the import of precursor proteins into the organelles...

Research Grants72

  1. Plasma and CSF Abeta peptides in late-onset major depression
    Nunzio Pomara; Fiscal Year: 2007
    ..If these hypotheses are confirmed, then the determination of plasma A/?42 might become an easily obtainable marker to identify those individuals with late-onset LLMD who may have prodromal AD. ..
  2. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2010
    ..to ATP, a NOS agonist, and postnatal oxygen tension stimulate the association of eNOS with the mitochondrial outer membrane protein, porin in normal fetal lamb pulmonary artery endothelial cells (PAEC)...
  3. MITOCHONDRIAL PROTEIN IMPORT IN AFRICAN TRYPANOSOMES
    Minu Chaudhuri; Fiscal Year: 2002
    ..expressed during the parasite life cycle; 2) to clone and characterize components of the TOM complex (TOM70, TOM40, TOM22, and TOM20) from T...
  4. Genetic control of mitochondrial aggregation in Drosophila spermatogenesis
    KAREN HALES; Fiscal Year: 2007
    ..cerevisiae mitochondrial outer membrane protein of unknown function...
  5. Novel intervention strategy for mitochondrial ROS toxicity
    Yisang Yoon; Fiscal Year: 2006
    ..Conversely, inhibition of mitochondrial fission prevents apoptotic progression. The mitochondrial outer membrane protein hFis1 recruits the membrane severing protein DLP1 to mediate mitochondrial fission...
  6. Proteomic and Functional Studies of Mitochondria in ALS
    Haining Zhu; Fiscal Year: 2007
    ..Our preliminary results have shown a mitochondrial outer membrane protein named "voltage dependent anion channel 2 (VDAC2)" as a promising target and this protein will be ..
  7. Molecular Epidemiology of MI and Stroke in Older Adults
    Alexander Reiner; Fiscal Year: 2006
    ....
  8. Thrombosis Genetics, MI and Stroke in Older Adults
    Alexander P Reiner; Fiscal Year: 2010
    ....
  9. Genetic Dissection of Sickle Cell Anemia Phenotypes
    Paola Sebastiani; Fiscal Year: 2006
    ..abstract_text> ..
  10. Analysis of Apolipoprotein H in Lupus
    M Kamboh; Fiscal Year: 2006
    ..Aim 5) perform in vitro mutagenesis and expression studies to express different apoH allelic-isoforms to evaluate isoform-specific inhibition of LDL oxidation. ..
  11. EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROME
    Nicole Schupf; Fiscal Year: 2009
    ..The proposed studies will clarify biological mechanisms relating variations in estrogen to the development of AD. ..
  12. Genetic Determinants of HDL-Cholesterol
    M Ilyas Kamboh; Fiscal Year: 2010
    ..As a result of these analyses, we should be able to definitively determine both rare and common variants that contribute to high and low HDL-C levels. ..
  13. ABETA TOXICITY, ROS AND MITOCHONDRIAL DYSFUNCTION IN AGING/ALZHEIMER'S DISEASE
    P Hemachandra Reddy; Fiscal Year: 2010
    ..Aim 3 will provide a mechanistic test of the hypothesis by characterizing neuroprotective mechanisms of mitochondrial oxidative damage, and will take us closer to identifying novel therapies of AD. ..
  14. Exploring the consequences of the TNFRSF1A susceptibility allele for MS
    Philip L De Jager; Fiscal Year: 2010
    ....
  15. Vascular Risk Factors in Alzheimer's Disease
    Gail Li; Fiscal Year: 2006
    ..abstract_text> ..
  16. Genetic Determinants of HDL-Cholesterol
    M Kamboh; Fiscal Year: 2009
    ..As a result of these analyses, we should be able to definitively determine both rare and common variants that contribute to high and low HDL-C levels. ..
  17. Prothrombin Gene Variation and the Risk of SLE and CHD
    M Ilyas Kamboh; Fiscal Year: 2010
    ....
  18. Plasma and CSF Abeta peptides in late-onset major depression
    Nunzio Pomara; Fiscal Year: 2010
    ..If these hypotheses are confirmed, then the determination of plasma A/?42 might become an easily obtainable marker to identify those individuals with late-onset LLMD who may have prodromal AD. ..
  19. PET IMAGING & MAPPING
    Steven Potkin; Fiscal Year: 2002
    ..3. Retrospect ively evaluate the fMRI structural and neuropsychological data, comparing the performance of those who did and did not show cognitive declines beyond normal age-associated memory impairment (AAMI). ..
  20. APOE Gene-Based Haplotype Study in Alzeheimer's Disease
    Chang En Yu; Fiscal Year: 2005
    ..2. Analyze the association between APOE haplotypes and AD. 3. Establish association between APOE expression level and haplotypes. 4. Identify critical SNPs from candidate haplotypes that affect APOE expression. ..
  21. Function BIRN
    Steven Potkin; Fiscal Year: 2007
    ..When completed, researchers in different fields and physical locations will be able to draw on a common set of tools and database systems not possible at a single site. ..
  22. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..These goals could not be achieved without a unifying Center focused on a single integrative theme. The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. ..
  23. LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGED
    Nunzio Pomara; Fiscal Year: 2005
    ..index of brain white matter organization) contribute most strongly to the acute effects of lorazepam on cognitive/motor performance or postural sway in elderly individuals receiving long-term lorazepam treatment for GAD? ..