Tom20

Summary

Gene Symbol: Tom20
Description: translocase of outer mitochondrial membrane 20
Alias: MAS20, MOM19, TOM20, mitochondrial import receptor subunit TOM20 homolog, mitochondrial 20 kDa outer membrane protein, outer mitochondrial membrane receptor Tom20, translocase of outer mitochondrial membrane 20 homolog type II
Species: human
Products:     Tom20

Top Publications

  1. Yano M, Hoogenraad N, Terada K, Mori M. Identification and functional analysis of human Tom22 for protein import into mitochondria. Mol Cell Biol. 2000;20:7205-13 pubmed
    ..Tom22 forms a complex with Tom20, and its cytosolic domain functions as an import receptor as in fungi...
  2. Yano M, Kanazawa M, Terada K, Takeya M, Hoogenraad N, Mori M. Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria. J Biol Chem. 1998;273:26844-51 pubmed
    The mitochondrial import receptor translocase of the outer membrane of mitochondria (Tom20) consists of five segments, an N-terminal membrane-anchor segment, a linker segment rich in charged amino acids, a tetratricopeptide repeat motif, ..
  3. Goping I, Millar D, Shore G. Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast. FEBS Lett. 1995;373:45-50 pubmed
    The human homolog of the S. cerevisiaelN. crassa mitochondrial protein import receptor, Mas20p/MOM19, has been identified and characterized...
  4. Lazarou M, Jin S, Kane L, Youle R. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell. 2012;22:320-33 pubmed publisher
    ..We propose that the association of PINK1 with the TOM complex allows rapid reimport of PINK1 to rescue repolarized mitochondria from mitophagy, and discount mitochondrial-specific factors for Parkin translocation and activation. ..
  5. Jin H, Zhu Y, Li Y, Ding X, Ma W, Han X, et al. BDNF-mediated mitophagy alleviates high-glucose-induced brain microvascular endothelial cell injury. Apoptosis. 2019;: pubmed publisher
    ..In addition, BDNF-induced mitophagy played a protective role against BMEC damage under hyperglycemia. Thus, the results of this study suggest that BDNF/TrkB/HIF-1α/BNIP3-mediated mitophagy protects BMECs from hyperglycemia. ..
  6. Gadir N, Haim Vilmovsky L, Kraut Cohen J, Gerst J. Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiae. RNA. 2011;17:1551-65 pubmed publisher
    ..of ATP2 and OXA1 mRNA localization and found a mutual dependency on the 3' UTR, Puf3, Tom7, and Tom70, but not Tom20, for localization...
  7. Khatami F, Payab M, Sarvari M, Gilany K, Larijani B, Arjmand B, et al. Oncometabolites as biomarkers in thyroid cancer: a systematic review. Cancer Manag Res. 2019;11:1829-1841 pubmed publisher
    ..Citrate was suggested as the first most significant biomarker and lactate as the second one. Further research is needed to confirm these biomarkers as the TC diagnostic oncometabolite. ..
  8. Zhang N, Liu X, Xie L, Shen X, Wu J. Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis. Lab Invest. 2019;: pubmed publisher
    ..The new insights into inflammasome activation through mitophagy advance our understanding of how fatty acids elicit lipotoxicity through oxidant stress and autophagy in mitochondria. ..
  9. Monzio Compagnoni G, Kleiner G, Bordoni A, Fortunato F, Ronchi D, Salani S, et al. Mitochondrial dysfunction in fibroblasts of Multiple System Atrophy. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3588-3597 pubmed publisher
    ..Furthermore, these findings will hopefully contribute to identify novel therapeutic targets for this still incurable disorder. ..

More Information

Publications105 found, 100 shown here

  1. Franco Iborra S, Cuadros T, Parent A, Romero Gimenez J, Vila M, Perier C. Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease. Cell Death Dis. 2018;9:1122 pubmed publisher
    ..was associated with a downregulation of two key components of the system: translocase of the outer membrane 20 (TOM20) and translocase of the inner membrane 23 (TIM23), both in vitro and in vivo...
  2. Yang X, Yan X, Yang D, Zhou J, Song J, Yang D. Rapamycin attenuates mitochondrial injury and renal tubular cell apoptosis in experimental contrast-induced acute kidney injury in rats. Biosci Rep. 2018;38: pubmed publisher
    ..Rapamycin exerts renoprotective effects against CI-AKI by attenuating mitochondrial injury and oxidative stress, which might be associated with increasing mitophagy. ..
  3. Gehrke S, Wu Z, Klinkenberg M, Sun Y, Auburger G, Guo S, et al. PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane. Cell Metab. 2015;21:95-108 pubmed publisher
    ..Translationally repressed nRCC mRNAs are localized in a PINK1/Tom20-dependent manner to mitochondrial outer membrane, where they are derepressed and activated by PINK1/Parkin through ..
  4. Feng R, Cai M, Wang X, Zhang J, Tian Z. Early Aerobic Exercise Combined with Hydrogen-Rich Saline as Preconditioning Protects Myocardial Injury Induced by Acute Myocardial Infarction in Rats. Appl Biochem Biotechnol. 2019;187:663-676 pubmed publisher
    ..damage in the MI model of rats and detected the effects of eAE-HRS on the expressions of cardiac OGG1 and Tom40, Tom20, and Tim23...
  5. Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, et al. Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. Cell Death Differ. 2018;25:873-884 pubmed publisher
    ..increases LC3 maturation as well as optineurin and NDP52 autophagy receptors expression and down-regulates TIM23, TOM20 and HSP60 mitophagy markers. Importantly, this phenotype is mimicked by TP53 invalidation in mice brain...
  6. Mani J, Desy S, Niemann M, Chanfon A, Oeljeklaus S, Pusnik M, et al. Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances. Nat Commun. 2015;6:6646 pubmed publisher
    ..that have a unique topology and unique protein domains and thus evolved independently of the prototype receptors Tom20 and Tom70...
  7. Zhou B, Zhang J, Liu X, Chen H, Ai Y, Cheng K, et al. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res. 2018;28:1171-1185 pubmed publisher
    ..Here, we demonstrate that iron-activated ROS can induce pyroptosis via a Tom20-Bax-caspase-GSDME pathway...
  8. Hwang H, Dornbos P, Steidemann M, Dunivin T, Rizzo M, LaPres J. Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol. 2016;304:121-32 pubmed publisher
    ..Collectively, these studies suggest that mitoAHR is localized to the IMS and AHR-dependent TCDD-induced toxicity, including metabolic dysfunction, wasting syndrome, and hepatic steatosis, involves mitochondrial dysfunction. ..
  9. Tahrir F, Knezevic T, Gupta M, Gordon J, Cheung J, Feldman A, et al. Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes. J Cell Physiol. 2017;232:797-805 pubmed publisher
    ..Suppression of BAG3 in NRVCs significantly reduces autophagy flux and eliminates clearance of Tom20, an essential import receptor for mitochondria proteins, after induction of mitophagy...
  10. Ota K, Obayashi M, Ozaki K, Ichinose S, Kakita A, Tada M, et al. Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy. Acta Neuropathol Commun. 2014;2:136 pubmed publisher
    ..4%). In contrast, TPPP accumulated in the perinuclear cytoplasm where mitochondrial membrane (TOM20 and cytochrome C) and fission (DRP1) proteins were often immunoreactive...
  11. Bauckman K, Haller E, Taran N, Rockfield S, Ruiz Rivera A, Nanjundan M. Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells. Biochem J. 2015;466:401-13 pubmed publisher
    ..damage (via TEM) and reduced expression of outer mitochondrial membrane proteins (translocase of outer membrane: TOM20 and TOM70) in cell lines sensitive to iron...
  12. Frank D, Dengjel J, Wilfling F, Kozjak Pavlovic V, Hacker G, Weber A. The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM). PLoS ONE. 2015;10:e0123341 pubmed publisher
    ..We found an interaction of Bim with Tom70, Tom20 and more weakly with Tom40, all components of the Translocase of the Outer Membrane (TOM)...
  13. Park S, Choi S, Yoo S, Nah J, Jeong E, Kim H, et al. Pyruvate stimulates mitophagy via PINK1 stabilization. Cell Signal. 2015;27:1824-30 pubmed publisher
    ..Rather, pyruvate was required for the interaction between PINK1 and TOMM20 under CCCP condition. These results suggest that pyruvate is required for CCCP-induced PINK1/PARK2-mediated mitophagy. ..
  14. Nyindodo Ogari L, Schwartzbach S, Estraño C. Giardia mitosomal protein import machinery differentially recognizes mitochondrial targeting signals. Infect Disord Drug Targets. 2014;14:23-9 pubmed
    ..These recombinant proteins include Tom20 and Tom22; two components of the mitochondrial protein import machinery...
  15. Aguileta M, Korać J, Durcan T, Trempe J, Haber M, Gehring K, et al. The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13. J Biol Chem. 2015;290:7492-505 pubmed publisher
    ..However, it did delay the clearance of mitochondrial proteins (TIM23, TIM44, and TOM20) and enhance parkin autoubiquitination...
  16. Fan Z, Yu H, Cui N, Kong X, Liu X, Chang Y, et al. ABT737 enhances cholangiocarcinoma sensitivity to cisplatin through regulation of mitochondrial dynamics. Exp Cell Res. 2015;335:68-81 pubmed publisher
    ..Mitophagy was induced by the combined treatment. Knockdown p62 decreased the Drp1 ratio, increased Tom20, and increased cell viability...
  17. Federighi G, Traina G, Bernardi R, Baldi E, Bucherelli C, Scuri R. Contextual fear conditioning modulates the gene expression over time. Arch Ital Biol. 2018;156:40-47 pubmed publisher
    ..Interestingly, 20 days after CFC, the genes Stmn1 and Tiprl again became significantly more expressed in CFC rats compared with naïve, SO and explor rats. ..
  18. Saleem A, Iqbal S, Zhang Y, Hood D. Effect of p53 on mitochondrial morphology, import, and assembly in skeletal muscle. Am J Physiol Cell Physiol. 2015;308:C319-29 pubmed publisher
    ..mitochondria was unaffected in the absence of p53, despite mitochondrial subfraction-specific reductions in Tom20, Tim23, mtHsp70, and mtHsp60 in the knockout (KO) mitochondria...
  19. Chen G, Cheng X, Zhao M, Lin S, Lu J, Kang J, et al. RIP1-dependent Bid cleavage mediates TNFα-induced but Caspase-3-independent cell death in L929 fibroblastoma cells. Apoptosis. 2015;20:92-109 pubmed publisher
    ..In addition, the mitochondrial outer membrane protein Tom20 was also reduced, indicating that the reduced mitochondria proteins may be induced by the reduced mitochondria ..
  20. Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, et al. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy. 2015;11:547-59 pubmed publisher
    ..Reduced PARK2 expression levels in COPD lung suggest that insufficient mitophagy is a part of the pathogenic sequence of COPD. ..
  21. Nanao T, Koike M, Yamaguchi J, Sasaki M, Uchiyama Y. Cellular localization and tissue distribution of endogenous DFCP1 protein. Biomed Res. 2015;36:121-33 pubmed publisher
    ..In HeLa cells under normal conditions, immunoreactivity for DFCP1 was found dotted or tubular along Tom20-positive filamentous mitochondria and was only partially co-localized in the ER or Golgi apparatus...
  22. Große L, Wurm C, Brüser C, Neumann D, Jans D, Jakobs S. Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis. EMBO J. 2016;35:402-13 pubmed publisher
    ..indicates that the area enclosed by a Bax ring is devoid of mitochondrial outer membrane proteins such as Tom20, Tom22, and Sam50...
  23. Morgan R, Hernández Ramírez L, Trivellin G, Zhou L, Roe S, Korbonits M, et al. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. PLoS ONE. 2012;7:e53339 pubmed publisher
    ..We have also identified a molecular switch in the AIP TPR-domain that allows recognition of both the conserved HSP90 motif, MEEVD, and the equivalent sequence (EDDVE) of TOMM20. ..
  24. Zhang W, Zhang S, Li B, Sun M, Zhang J. Paravertebral dexmedetomidine as an adjuvant to ropivacaine protects against independent lung injury during one-lung ventilation: a preliminary randomized clinical trial. BMC Anesthesiol. 2018;18:67 pubmed publisher
    ..TNF-α, IL-6, miRNA-210, HIF-1α, Tom20 and ISCU2 were also detected...
  25. Li Q, Vande Velde C, Israelson A, Xie J, Bailey A, Dong M, et al. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc Natl Acad Sci U S A. 2010;107:21146-51 pubmed publisher
    ..in protein import only in spinal cord mitochondria, despite an increase in the mitochondrial import components TOM20, TOM22, and TOM40...
  26. Martella G, Madeo G, Maltese M, Vanni V, Puglisi F, Ferraro E, et al. Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice. Neurobiol Dis. 2016;91:21-36 pubmed publisher
    ..8mg/kg) treatment did not induce mislocalization of the mitochondrial membrane protein Tom20 and release of cytochrome c in PINK1(+/-) striata...
  27. Zeng R, Fang Y, Zhang Y, Bai S. p62 is linked to mitophagy in oleic acid-induced adipogenesis in human adipose-derived stromal cells. Lipids Health Dis. 2018;17:133 pubmed publisher
    ..Moreover, the copy number of mtDNA (the ND1 gene) and the protein level of TOM20, a mitochondrial membrane protein, were increased following OA treatment, which was related to the stability of ..
  28. Asmarinah A, Paradowska Dogan A, Kodariah R, Tanuhardja B, Waliszewski P, Mochtar C, et al. Expression of the Bcl-2 family genes and complexes involved in the mitochondrial transport in prostate cancer cells. Int J Oncol. 2014;45:1489-96 pubmed
    ..The pro-apoptotic Bax protein was downtranslated significantly in secretory cells of prostate cancer as compared to normal prostate. We suggest that this protein is a good candidate as biomarker for prostate cancer. ..
  29. Liang J, Martinez A, Lane J, Mayor U, Clague M, Urbé S. USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death. EMBO Rep. 2015;16:618-27 pubmed publisher
    ..The unique mitochondrial deubiquitylase, USP30, opposes Parkin-dependent ubiquitylation of TOM20, and its depletion enhances depolarization-induced cell death in Parkin-overexpressing cells...
  30. Fabbri A, Travaglione S, Maroccia Z, Guidotti M, Pierri C, Primiano G, et al. The Bacterial Protein CNF1 as a Potential Therapeutic Strategy against Mitochondrial Diseases: A Pilot Study. Int J Mol Sci. 2018;19: pubmed publisher
    ..able to trigger a significant increase in cellular content of ATP and of the mitochondrial outer membrane marker Tom20. These results were accompanied by a profound F-actin reorganization in MERRF fibroblasts, which is a typical CNF1-..
  31. Noble S, Godoy R, Affaticati P, Ekker M. Transgenic Zebrafish Expressing mCherry in the Mitochondria of Dopaminergic Neurons. Zebrafish. 2015;12:349-56 pubmed publisher
    ..dat) gene to target a reporter, mCherry, after fusion with the mitochondrial localizing signal (MLS) of Tom20. Immunoblot analysis of mitochondrial and cytosolic fractions from Tg(dat:tom20 MLS-mCherry) larvae shows that ..
  32. Ornelas A, McCullough C, Lu Z, Zacharias N, Kelderhouse L, Gray J, et al. Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models. BMC Cancer. 2016;16:824 pubmed
    ..resulted in a reduction in mitochondrial respiration, decreased mitochondrial membrane potential, and decreased Tom20 staining suggesting an ARHI-dependent loss of mitochondrial function...
  33. Urvalek A, Osei Sarfo K, Tang X, Zhang T, Scognamiglio T, Gudas L. Identification of Ethanol and 4-Nitroquinoline-1-Oxide Induced Epigenetic and Oxidative Stress Markers During Oral Cavity Carcinogenesis. Alcohol Clin Exp Res. 2015;39:1360-72 pubmed publisher
    ..4-NQO/EtOH treatment also caused increases in markers of oxidative stress, including 4-HNE, MCT4/SLC16a3, and TOM20, as measured by immunohistochemistry...
  34. Demarest T, Waite E, Kristian T, Puche A, Waddell J, McKenna M, et al. Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia-ischemia. Neuroscience. 2016;335:103-13 pubmed publisher
    ..Autophagosome formation, lysosome size, and TOM20/LAMP2 co-localization were increased in the contralateral hemisphere following HI in female, but not male brain...
  35. Wei F, Xiao H, Hu Z, Zhang H, Wang C, Dai H, et al. [Subcellular localization of ataxin-3 and its effect on the morphology of cytoplasmic organoids]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015;32:353-7 pubmed publisher
    ..No co-localization was observed for ataxin-3 protein and mitochondrial marker TOM20, but the percentage of cells with mitochondrial fragmentation has increased in cells expressing mutant ataxin-3 (P&..
  36. Gao H, Chen Z, Fu Y, Yang X, Weng R, Wang R, et al. Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress. Sci Rep. 2016;6:34403 pubmed publisher
    ..caused Nur77 translocation from the nucleus to cytosol and Endoplasm reticulum (ER) and induced co-localization of Tom20/Nur77 and Protein Disulfide Isomerase (PDI)/Nur77...
  37. Yilmaz E, Watkins S, Gold M. Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca2+ in putative nociceptive glabrous skin neurons from the rat. Cell Calcium. 2017;62:16-28 pubmed publisher
    ..transient duration in putative nociceptive glabrous skin neurons, as well as increases in mitotracker and Tom20 staining which reflected an increase in mitochondrial volume...
  38. Wu M, Liu X, Chi X, Zhang L, Xiong W, Chiang S, et al. Mitophagy in Refractory Temporal Lobe Epilepsy Patients with Hippocampal Sclerosis. Cell Mol Neurobiol. 2018;38:479-486 pubmed publisher
    ..Aberrant accumulation of damaged mitochondria, especially in the hippocampus, can be attributed to defects in mitophagy, which may participate in epileptogenesis. ..
  39. Grillon E, Farion R, Reuveni M, Glidle A, Rémy C, Coles J. Spatial profiles of markers of glycolysis, mitochondria, and proton pumps in a rat glioma suggest coordinated programming for proliferation. BMC Res Notes. 2015;8:207 pubmed publisher
    ..Over distances up to 2.5 mm into the glioma, expression of a marker of the TCA cycle, Tom20, a pre-protein receptor on the translocation complex of the mitochondrial outer membrane, was also upregulated...
  40. Kawalec M, Boratyńska Jasińska A, Beręsewicz M, Dymkowska D, Zabłocki K, Zabłocka B. Mitofusin 2 Deficiency Affects Energy Metabolism and Mitochondrial Biogenesis in MEF Cells. PLoS ONE. 2015;10:e0134162 pubmed publisher
    ..This effect was correlated with increased level of mitochondrial markers (TOM20 and NAO) as well as mitochondrial transcription factor A (TFAM) and peroxisome proliferator-activated receptor ..
  41. Huang S, Noble S, Godoy R, Ekker M, Chan H. Delayed effects of methylmercury on the mitochondria of dopaminergic neurons and developmental toxicity in zebrafish larvae (Danio rerio). Aquat Toxicol. 2016;175:73-80 pubmed publisher
    ..lines: Tg(dat:eGFP) expressing enhanced green fluorescent protein (eGFP) in DA neuron clusters and Tg(dat:tom20 MLS-mCherry) expressing red fluorescence (mCherry) targeted to mitochondria of DA neurons were used to evaluate ..
  42. Backes S, Hess S, Boos F, Woellhaf M, Gödel S, Jung M, et al. Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences. J Cell Biol. 2018;217:1369-1382 pubmed publisher
    ..N-terminal matrix-targeting signals (MTSs) direct preproteins to the surface receptors Tom20, Tom22, and Tom70...
  43. Wojtkowska M, Buczek D, Stobienia O, Karachitos A, Antoniewicz M, Slocinska M, et al. The TOM Complex of Amoebozoans: the Cases of the Amoeba Acanthamoeba castellanii and the Slime Mold Dictyostelium discoideum. Protist. 2015;166:349-62 pubmed publisher
    ..castellanii and D. discoideum TOM complex, while the presence of Tom22 and Tom20 is less supported...
  44. Li M, Qu Y, Mu D. [Role of mitophagy in neonatal rats with hypoxic-ischemic brain damage]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:242-249 pubmed
    ..05), and a significant reduction in the expression of the mitochondrial outer membrane protein Tom20 and the mitochondrial inner membrane protein Tim23 (P<0.05)...
  45. Han G, Liu K, Li L, Li X, Zhao P. The effects of hyperbaric oxygen therapy on neuropathic pain via mitophagy in microglia. Mol Pain. 2017;13:1744806917710862 pubmed publisher
    ..Immunofluorescence changes in neuron protein (NESTIN) and mitochondria inner or outer layer proteins (TIM23, TOM20) were examined...
  46. De Paoli S, Tegegn T, Elhelu O, Strader M, Patel M, Diduch L, et al. Dissecting the biochemical architecture and morphological release pathways of the human platelet extracellular vesiculome. Cell Mol Life Sci. 2018;75:3781-3801 pubmed publisher
    ..Interestingly, a flow cytometry showed a population of TOM20+LC3+ PEVs, likely products of platelet mitophagy...
  47. Filadi R, Leal N, Schreiner B, Rossi A, Dentoni G, Pinho C, et al. TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer. Curr Biol. 2018;28:369-382.e6 pubmed publisher
    ..Among its subunits, TOM70 and TOM20 are only transiently associated with the core complex, suggesting their possible additional roles within the outer ..
  48. Sumi Akamaru H, Beck G, Shinzawa K, Kato S, Riku Y, Yoshida M, et al. High expression of ?-synuclein in damaged mitochondria with PLA2G6 dysfunction. Acta Neuropathol Commun. 2016;4:27 pubmed publisher
    ..The granules were mitochondrial outer membrane protein (TOM20)-positive...
  49. Yu S, Zheng S, Leng J, Wang S, Zhao T, Liu J. Inhibition of mitochondrial calcium uniporter protects neurocytes from ischemia/reperfusion injury via the inhibition of excessive mitophagy. Neurosci Lett. 2016;628:24-9 pubmed publisher
    ..significantly reduced OGD/RP induced mitophagy as evidenced by the decrease in Beclin-1 and the increase in Tom20 and P62 expression...
  50. Aparicio I, Espino J, Bejarano I, Gallardo Soler A, Campo M, Salido G, et al. Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility. Sci Rep. 2016;6:33647 pubmed publisher
    ..Autophagy activation induced a significant increase in motility and a decrease in PINK1, TOM20 expression and caspase 3/7 activation...
  51. Nardin A, Schrepfer E, Ziviani E. Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease. Curr Neuropharmacol. 2016;14:250-9 pubmed
    ..Mitochondrial outer membrane proteins Mitofusin (MFN), VDAC, Fis1 and TOM20 were found to be targets for Parkin mediated ubiquitination [9-11]...
  52. Fan J, Li X, Issop L, Culty M, Papadopoulos V. ACBD2/ECI2-Mediated Peroxisome-Mitochondria Interactions in Leydig Cell Steroid Biosynthesis. Mol Endocrinol. 2016;30:763-82 pubmed publisher
    ..Considering the widespread occurrence of the ACBD2/ECI2 protein, we propose that this protein might serve as a tool to assist in understanding the contact between peroxisomes and mitochondria. ..
  53. Mukhopadhyay A, Avramova L, Weiner H. Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins. Arch Biochem Biophys. 2002;400:97-104 pubmed
    b>Tom20 and Tom34 are mammalian liver proteins previously identified by others to be components of the mitochondrial import translocation apparatus...
  54. Yano M, Terada K, Mori M. AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins. J Cell Biol. 2003;163:45-56 pubmed
    ..arylhydrocarbon receptor-interacting protein (AIP), an FK506-binding protein homologue, interacting with Tom20. The extreme COOH-terminal acidic segment of Tom20 was required for interaction with tetratricopeptide repeats of ..
  55. Humphries A, Streimann I, Stojanovski D, Johnston A, Yano M, Hoogenraad N, et al. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005;280:11535-43 pubmed
    ..Nevertheless, we show that Tom40 assembly is reduced in mitochondria depleted of human Sam50. These findings are discussed in context with current models from fungal studies. ..
  56. Balaker A, Ishiyama P, Lopez I, Ishiyama G, Ishiyama A. Immunocytochemical localization of the translocase of the outer mitochondrial membrane (Tom20) in the human cochlea. Anat Rec (Hoboken). 2013;296:326-32 pubmed publisher
    ..In this study, we determined the immunolocalization of Tom20, a major mitochondrial protein import receptor, in microdissected human cochlea frozen sections obtained from ..
  57. Melin J, Kilisch M, Neumann P, Lytovchenko O, Gomkale R, Schendzielorz A, et al. A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria. Biochim Biophys Acta. 2015;1853:1850-9 pubmed publisher
    ..Aside from the well-characterized presequence receptors Tom20 and Tom22 a third TOM receptor, Tom70, binds proteins of the carrier family containing multiple transmembrane ..
  58. Johnson J, Lai S, Cotzia P, Cognetti D, Luginbuhl A, Pribitkin E, et al. Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer. Semin Oncol. 2015;42:915-22 pubmed publisher
    ..PTC has low expression of MCT1 and non-cancerous thyroid tissue has low expression of both MCT1 and TOMM20. This work suggests that MCT1 blockade may specifically target ATC cells presenting an opportunity for a new drug target. ..
  59. Zhang B, Xu D, She L, Wang Z, Yang N, Sun R, et al. Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease. FASEB J. 2018;32:757-767 pubmed publisher
    ..In addition, silybin inhibited the approach of calreticulin and translocase of outer membrane 20 (Tom20), prevented assembly of the NLRP3 inflammasome complex, and suppressed the accumulation of acetylated α-tubulin ..
  60. Suresh S, Abdurehman L, Osmani A, Osmani S. Tools for retargeting proteins within Aspergillus nidulans. PLoS ONE. 2017;12:e0189077 pubmed publisher
    ..Using these base cassettes, fusion PCR, and gene targeting approaches, we generated strains with SPA10-GBP and Tom20-GBP gene replacements...
  61. Murata H, Sakaguchi M, Kataoka K, Huh N. SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria. Mol Biol Cell. 2013;24:2772-84 pubmed publisher
    ..Some pathogenic mutations of PINK1 reduce the complex formation and ubiquitination. These results indicate that association of PINK1 with SARM1 and TRAF6 is an important step for mitophagy. ..
  62. Roberts B, Haupt A, Tucker A, Grancharova T, Arakaki J, Fuqua M, et al. Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization. Mol Biol Cell. 2017;28:2854-2874 pubmed publisher
    ..nuclear lamin B1, nonmuscle myosin heavy chain IIB, paxillin, Sec61 beta, tight junction protein ZO1, and Tom20. Our genome-editing methodology using Cas9/crRNA ribonuclear protein and donor plasmid coelectroporation, followed ..
  63. Gersch M, Gladkova C, Schubert A, Michel M, Maslen S, Komander D. Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat Struct Mol Biol. 2017;24:920-930 pubmed publisher
    ..numerous mitochondrial substrates for this modification, and we show that USP30 regulates Lys6-polyubiquitinated TOM20. Our work provides insights into the architecture, activity and regulation of USP30, which will aid drug design ..
  64. Abdul K, Terada K, Yano M, Ryan M, Streimann I, Hoogenraad N, et al. Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex. Biochem Biophys Res Commun. 2000;276:1028-34 pubmed
    ..showed that distribution of metaxin mRNA in human tissues differs from that of mRNA for the translocase component Tom20. Effect of overexpression of human metaxin on mitochondrial preprotein import and processing in COS-7 cells was ..
  65. Mamada N, Tanokashira D, Ishii K, Tamaoka A, Araki W. Mitochondria are devoid of amyloid ?-protein (A?)-producing secretases: Evidence for unlikely occurrence within mitochondria of A? generation from amyloid precursor protein. Biochem Biophys Res Commun. 2017;486:321-328 pubmed publisher
    ..Additionally, immunocytochemical analysis showed very little co-localization between presenilin 1 and Tom20, a marker protein of mitochondria...
  66. Chandra G, Kundu M, Rangasamy S, Dasarathy S, Ghosh S, Watson R, et al. Increase in Mitochondrial Biogenesis in Neuronal Cells by RNS60, a Physically-Modified Saline, via Phosphatidylinositol 3-Kinase-Mediated Upregulation of PGC1α. J Neuroimmune Pharmacol. 2018;13:143-162 pubmed publisher
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    ..identified a human protein of 16 kDa with significant overall homology to the fungal mitochondrial import receptor Mom19, including the three typical characteristics: a hydrophobic N-terminal segment, a tetratrico peptide motif in the ..
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    ..Taken together, these results indicate that OM38 is a structural and functional homolog of fungal Tom40 and functions as a component of the preprotein import machinery of the rat mitochondrial outer membrane. ..
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    ..We now report that certain posttranslationally modified species of ?-synuclein bind with high affinity to the TOM20 (translocase of the outer membrane 20) presequence receptor of the mitochondrial protein import machinery...
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    ..In addition, double deletion of STI1 with the mitochondrial import factors, MIM1 or TOM20, showed a synthetic growth phenotype indicating a genetic interaction of STI1 with these genes...
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