Gene Symbol: TOM1L1
Description: target of myb1 like 1 membrane trafficking protein
Alias: SRCASM, TOM1-like protein 1, src-activating and signaling molecule protein, target of Myb-like protein 1
Species: human
Products:     TOM1L1

Top Publications

  1. Liu N, Loo L, Loh E, Seet L, Hong W. Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor. EMBO J. 2009;28:3485-99 pubmed publisher
    ..We show here that EGF stimulates transient tyrosine phosphorylation of Tom1L1 by the Src family kinases, resulting in transient interaction of Tom1L1 with the activated EGFR bridged by Grb2 ..
  2. Seroussi E, Kedra D, Kost Alimova M, Sandberg Nordqvist A, Fransson I, Jacobs J, et al. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. Genomics. 1999;57:380-8 pubmed
    ..Using a genomic PAC clone, we demonstrate that the mouse Tom1 and Hmox1 genes are part of an as yet undescribed syntenic group between mouse chromosome 8C1 and human chromosome 22q13.1. ..
  3. Seykora J, Mei L, Dotto G, Stein P. 'Srcasm: a novel Src activating and signaling molecule. J Biol Chem. 2002;277:2812-22 pubmed
    ..A novel adaptor-like molecule was isolated and termed Srcasm for Src activating and signaling molecule. Murine Srcasm is a 52...
  4. Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K. Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. J Biol Chem. 2004;279:24435-43 pubmed
    Tom1 (target of Myb1) is a protein of unknown function. Tom1 and its relative Tom1L1 have an N-terminal VHS (Vps27p/Hrs/Stam) domain followed by a GAT (GGA and Tom1) domain, both of which are also found in the GGA (Golgi-localizing, gamma-..
  5. Puertollano R. Interactions of TOM1L1 with the multivesicular body sorting machinery. J Biol Chem. 2005;280:9258-64 pubmed
    b>Tom1L1 (Tom1-like1) and related proteins Tom1 (Target of Myb1) and Tom1L2 (Tom1-like2) constitute a new protein family characterized by the presence of a VHS (Vps27p/Hrs/Stam) domain in the N-terminal portion followed by a GAT (GGA and ..
  6. Katoh Y, Imakagura H, Futatsumori M, Nakayama K. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Biochem Biophys Res Commun. 2006;341:143-9 pubmed
    Tom1 (target of Myb 1) and its related proteins (Tom1L1/Srcasm and Tom1L2) constitute a protein family and share an N-terminal VHS (Vps27p/Hrs/Stam) domain and a following GAT (GGA and Tom1) domain, both of which are also conserved in the ..
  7. Franco M, Furstoss O, Simon V, Benistant C, Hong W, Roche S. The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Mol Cell Biol. 2006;26:1932-47 pubmed antiphosphotyrosine antibody to screen tyrosine-phosphorylated cDNA expression library, we have identified Tom1L1, an adaptor protein of the Tom1 family and a novel substrate and activator of the SFK...
  8. Collin G, Franco M, Simon V, Benistant C, Roche S. The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities. Mol Cell Biol. 2007;27:7631-40 pubmed
    ..How this Src subcellular localization is regulated is largely unknown. Here we show that the Tom1L1-clathrin heavy chain (CHC) complex negatively regulates the level of SFK in caveolae needed for the induction of ..
  9. Lee V, Yang X, Prouty S, Denchev T, Marshall C, Maeno H, et al. Srcasm Regulates Tyrosine Kinases in Skin Cancer: Implications for Precision Medicine. J Investig Dermatol Symp Proc. 2018;19:S103-S105 pubmed publisher
    ..With projected higher incidence of patients with cSCCs in the future, there is a strong need to elucidate the molecular pathways that regulate formation of cSCCs. ..

More Information


  1. Pini T, Rickard J, Leahy T, Crossett B, Druart X, De Graaf S. Cryopreservation and egg yolk medium alter the proteome of ram spermatozoa. J Proteomics. 2018;181:73-82 pubmed publisher
    ..Overall, 27 proteins increased (e.g. SERPINB1, FER) and 24 proteins decreased (e.g. CCT subunits, CSNK1G2, TOM1L1) in frozen thawed ram spermatozoa, compared to fresh spermatozoa...
  2. Lim W, Song G. Novel genes and hormonal regulation for gonadal development during embryogenesis in chickens. Gen Comp Endocrinol. 2015;211:20-7 pubmed publisher
    ..Therefore, we focused on three genes (TOM1L1, TTR, and ZEB1) that are related to cellular proliferation and embryonic development based on previous study ..
  3. Emaduddin M, Edelmann M, Kessler B, Feller S. Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells. Cell Commun Signal. 2008;6:7 pubmed publisher
    ..pY proteins subsequently identified several proteins readily known as SFK kinase substrates, including cortactin, Tom1L1 (SRCASM), GIT1, vimentin and AFAP1L2 (XB130)...
  4. Sirvent A, Vigy O, Orsetti B, Urbach S, Roche S. Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. Mol Cell Proteomics. 2012;11:1937-50 pubmed publisher confirmed this notion experimentally with the example of the vesicular trafficking protein and SRC substrate TOM1L1. We found that whereas TOM1L1 depletion only slightly affected SRC-induced proliferation of CRC cells in vitro, it ..
  5. Yanagida Ishizaki Y, Takei T, Ishizaki R, Imakagura H, Takahashi S, Shin H, et al. Recruitment of Tom1L1/Srcasm to endosomes and the midbody by Tsg101. Cell Struct Funct. 2008;33:91-100 pubmed
    Tom1 (target of Myb 1) and its related proteins (Tom1L1/Srcasm and Tom1L2) constitute a protein family, which share an N-terminal VHS (Vps27, Hrs and STAM) domain and a following GAT (GGA and Tom1) domain...
  6. Zhang J, Suzuki K, Hitomi T, Siraganian R. TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells. J Biol Chem. 2007;282:37669-77 pubmed
    ..A potential substrate of Lyn identified was the molecule TOM1L1, which has several domains thought to be important for membrane trafficking and protein-protein interactions...
  7. Chevalier C, Collin G, Descamps S, Touaitahuata H, Simon V, Reymond N, et al. TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion. Nat Commun. 2016;7:10765 pubmed publisher
    ..Here we report that TOM1L1 is co-amplified with ERBB2 and defines a subgroup of HER2(+)/ER(+) tumours with early metastatic relapse...
  8. Li W, Marshall C, Mei L, Dzubow L, Schmults C, Dans M, et al. Srcasm modulates EGF and Src-kinase signaling in keratinocytes. J Biol Chem. 2005;280:6036-46 pubmed
    The Src-activating and signaling molecule (Srcasm) is a recently described activator and substrate of Src-family tyrosine kinases (SFKs)...
  9. . Non-aligned movement support for South-South collaboration in the field of population and family planning. Integration. 1994;:37-42 pubmed
    ..The paper also discusses financial resources to support collaboration and offers a proposal of NAM arrangements to strengthen, support, and sustain South-South collaboration. ..
  10. Thalappilly S, Suliman M, Gayet O, Soubeyran P, Hermant A, Lecine P, et al. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. Proteomics. 2008;8:3071-81 pubmed publisher
    ..several molecules that modulate cell proliferation and survival (CIZ1, BIRC6, RBBP6), signaling (LTBP4, Notch2, TOM1L1, STK24) and membrane dynamics (PLSCR1, DDEF2, VCP)...
  11. Meulener M, Ayli E, Elenitsas R, Seykora J. Decreased Srcasm expression in hyperproliferative cutaneous lesions. J Cutan Pathol. 2009;36:291-5 pubmed publisher
    ..Src-activating and signaling molecule (Srcasm) is a recently identified molecule that downregulates SFK activity and promotes keratinocyte differentiation...
  12. Ren X, Hurley J. VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. EMBO J. 2010;29:1045-54 pubmed publisher
    ..Mutational analysis of all the five ubiquitin-binding sites in yeast ESCRT-0 shows that cooperation between them is required for the sorting of the Lys63-linked polyubiquitinated cargo Cps1 to the vacuole. ..
  13. Elmarghani A, Abuabaid H, Kjellen P. TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation. Mediators Inflamm. 2009;2009:416298 pubmed publisher
    ..Based on our results, we here propose that TOM1L is involved in a novel signaling pathway that is important for the IL-2 production in T cells. ..
  14. Qi Y, Li X, Zhao L, Seykora J. Decreased Srcasm expression in esophageal squamous cell carcinoma in a Chinese population. Anticancer Res. 2010;30:3535-9 pubmed
    ..Src-activating and signaling molecule (Srcasm) is a novel molecule that down-regulates SFK activity and promotes cell differentiation...