TOLLIP

Summary

Gene Symbol: TOLLIP
Description: toll interacting protein
Alias: IL-1RAcPIP, toll-interacting protein, adapter protein
Species: human
Products:     TOLLIP

Top Publications

  1. Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol. 2000;2:346-51 pubmed
    ..and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip. Here we show that, before IL-1beta treatment, Tollip is present in a complex with IRAK, and that recruitment of ..
  2. Bulut Y, Faure E, Thomas L, Equils O, Arditi M. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like recepto. J Immunol. 2001;167:987-94 pubmed
    ..Moreover, we show that Toll-interacting protein (Tollip) coimmunoprecipitates with TLR2 and TLR4 using HEK 293 cells, and overexpression of Tollip inhibits NF-kappaB ..
  3. Yamakami M, Yoshimori T, Yokosawa H. Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin. J Biol Chem. 2003;278:52865-72 pubmed
    ..In this study, we found that Tom1 binds directly with ubiquitin chains and Tollip, which was initially isolated as a mediator of interleukin-1 signaling and has a capacity to bind ubiquitin chains...
  4. Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K. Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. J Biol Chem. 2004;279:24435-43 pubmed
    ..In this study, we show that the GAT domains of Tom1 and Tom1L1 interact with ubiquitin and Tollip (Toll-interacting protein)...
  5. Shah J, Vary J, Chau T, Bang N, Yen N, Farrar J, et al. Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis. J Immunol. 2012;189:1737-46 pubmed publisher
    ..We hypothesized that TOLLIP and its common variants negatively regulate TLR signaling in human monocytes and are associated with ..
  6. Zhang G, Ghosh S. Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem. 2002;277:7059-65 pubmed
    ..The adaptor protein Tollip was identified initially as an intermediate in interleukin (IL)-1 signaling...
  7. Brissoni B, Agostini L, Kropf M, Martinon F, Swoboda V, Lippens S, et al. Intracellular trafficking of interleukin-1 receptor I requires Tollip. Curr Biol. 2006;16:2265-70 pubmed
    ..of IL-1RI and that via these attached ubiquitin groups, IL-1RI interacts with the ubiquitin-binding protein Tollip. By using an assay to follow trafficking of IL-1RI from the cell surface to late endosomes and lysosomes, we ..
  8. Schimming T, Parwez Q, Petrasch Parwez E, Nothnagel M, Epplen J, Hoffjan S. Association of toll-interacting protein gene polymorphisms with atopic dermatitis. BMC Dermatol. 2007;7:3 pubmed
    ..Toll-interacting protein (TOLLIP) is an inhibitory adaptor protein within the toll-like receptor (TLR) pathway, a part of the innate immune system ..
  9. Lee J, Lee H, Lee E, Jang S, Kim H, Yoon J, et al. Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling. Biochim Biophys Acta. 2009;1790:1673-80 pubmed publisher
    ..receptor (IL-1R)-mediated signaling by analyzing interaction between DSCR1-1S and the IL-1R pathway components Tollip, IRAK-1, and TRAF6...

More Information

Publications128 found, 100 shown here

  1. Huang H, Zeng Z, Wang K, Zhang H, Wang S, Zhou W, et al. Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. World J Gastroenterol. 2015;21:2937-48 pubmed publisher
    ..HO-1 protects liver against I/R injury by inhibiting TLR2/TLR4-triggered MyD88- and TRIF-dependent signaling pathways and increasing expression of negative regulators of TLR signaling in rats. ..
  2. Kulkarni R, Rasheed M, Bhaumik S, Ranjan P, Cao W, Davis C, et al. Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity. J Virol. 2014;88:13990-4001 pubmed publisher
    ..The effects induced by 5'ppp-dsRNA were significantly dependent on type I IFN and IPS-1 (an adapter protein downstream of the RIG-I pathway) signaling but were independent of the MyD88- and TLR3-mediated pathways...
  3. Zhou S, Li M, Yang N, Liu S, Yuan X, Tao Z, et al. First description and expression analysis of tumor necrosis factor receptor-associated factor 6 (TRAF6) from the swimming crab, Portunus trituberculatus. Fish Shellfish Immunol. 2015;45:205-10 pubmed publisher
    Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a cytoplasmic adapter protein that mediates signals induced by the tumor necrosis factor receptor (TNFR) superfamily and the interleukin-1 receptor (IL-1R)...
  4. Murphy M, Pattabiraman G, Manavalan T, Medvedev A. Deficiency in IRAK4 activity attenuates manifestations of murine Lupus. Eur J Immunol. 2017;47:880-891 pubmed publisher
    ..Thus, IRAK4 kinase activity contributes to murine lupus and could represent a new therapeutic target. ..
  5. Benz P, Laban H, Zink J, Günther L, Walter U, Gambaryan S, et al. Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets. Cell Commun Signal. 2016;14:21 pubmed publisher
    ..how VASP regulated Rap1b, we investigated association between VASP and the Crk-like protein (Crkl), an adapter protein which activates the Rap1b guanine nucleotide exchange factor C3G...
  6. Li Y, Zhu H, Zhang D, Li H, Ma P, Huang L. Novel endogenous negative modulators of platelet function as potential anti-thrombotic targets. Eur Rev Med Pharmacol Sci. 2017;21:3146-3158 pubmed
    ..II (PrxII), T-cell ubiquitin ligand-2 (TULA-2); (4) extracellular modulators released from platelet granules: adapter protein disabled-2 (DAB2) and diadenosine 5,5-P1, P2-diphosphate (Ap2A)...
  7. Xu Y, Huang Y, Cai S. Characterization and function analysis of interleukin-1 receptor-associated kinase-1 (IRAK-1) from Fenneropenaeus penicillatus. Fish Shellfish Immunol. 2017;61:111-119 pubmed publisher
    The interleukin-1 receptor-associated kinase-1 (IRAK-1) is an important adapter protein which links downstream of MyD88, and involved in the complex composed of MyD88 and TRAF6 to activate TLRs signaling pathway...
  8. Schmitz G, Schambeck C. Molecular defects in the ABCA1 pathway affect platelet function. Pathophysiol Haemost Thromb. 2006;35:166-74 pubmed
    ..protein (pallidin) whose deficiency leads to impaired platelet granule release from the dense granule Adapter Protein-3 (AP-3)-related pathway...
  9. Li C, Shen K, Chien L, Huang C, Wu T, He H. Proteomic Identification of the Galectin-1-Involved Molecular Pathways in Urinary Bladder Urothelial Carcinoma. Int J Mol Sci. 2018;19: pubmed publisher
    ..of glutamine synthetase, alcohol dehydrogenase (NADP?), fatty acid binding protein 4, and toll interacting protein in clinical specimens were all significantly associated with galectin-1 up-regulation...
  10. Huang Y, Chen Y, Wang Z, Wang W, Ren Q. Novel myeloid differentiation factor 88, EsMyD88, exhibits EsTube-binding activity in Chinese mitten crab Eriocheir sinensis. Dev Comp Immunol. 2014;47:298-308 pubmed publisher
    Myeloid differentiation factor 88 (MyD88) is a universal and essential adapter protein that participates in the activation of the Toll-like receptor/interleukin-1 receptor-mediated signaling pathway...
  11. Harun Or Rashid M, Inman D. Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma. J Neuroinflammation. 2018;15:313 pubmed publisher
    ..We also detected increased levels of Arrestin β-2 protein, an adapter protein required for HCAR1 signaling...
  12. Meng D, Zhu W, Ganguli K, Shi H, Walker W. Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors. Am J Physiol Gastrointest Liver Physiol. 2016;311:G744-G753 pubmed publisher
    ..TLR-4, downregulates the mRNA expression of interleukin-1 receptor-associated kinase 2 (IRAK-2), a common adapter protein shared by IL-1? and TLR-4 signaling...
  13. Blok D, Kager L, Hoogendijk A, Lede I, Rahman W, Afroz R, et al. Expression of inhibitory regulators of innate immunity in patients with active tuberculosis. BMC Infect Dis. 2015;15:98 pubmed publisher
    ..These results show enhanced expression of distinct negative regulators of innate immunity in PBMCs of patients with TB and identify plasma soluble ST2 as a potential novel biomarker for TB disease activity. ..
  14. Dutta D, Chakraborty B, Sarkar A, Chowdhury C, Das P. A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells. BMC Cancer. 2016;16:23 pubmed publisher
    ..levels of different autophagic proteins like Beclin-1, Atg 5, Atg 7, Atg 5-Atg 12, LC3B and autophagic adapter protein, p62...
  15. Caswell P, Dickens M. JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells. Mol Cell Biochem. 2018;444:1-13 pubmed publisher
    ..JIP3 also associates with microtubule motor proteins such as kinesin and dynein and is likely an adapter protein involved in the tethering of vesicular cargoes to the motors involved in axonal transport in neurons...
  16. Bishop G. TRAF3 as a powerful and multitalented regulator of lymphocyte functions. J Leukoc Biol. 2016;100:919-926 pubmed
    This review summarizes the current state of knowledge regarding the roles of the signaling adapter protein tumor necrosis factor receptor (TNFR)-associated factor 3 in regulating the functions of B and T lymphocytes...
  17. Hosmane S, Tegenge M, Rajbhandari L, Uapinyoying P, Ganesh Kumar N, Thakor N, et al. Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons. J Neurosci. 2012;32:7745-57 pubmed publisher
    ..Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF), a Toll-like receptor adapter protein, blocks induction of the interferon response and inhibits microglial phagocytosis of axon debris in vitro...
  18. Lin S, May E, Chang J, Hu R, Wang L, Chan H. PGRMC1 contributes to doxorubicin-induced chemoresistance in MES-SA uterine sarcoma. Cell Mol Life Sci. 2015;72:2395-409 pubmed publisher
    ..Progesterone receptor membrane component 1 (PGRMC1) is an adapter protein mediating cholesterol synthesis, steroid signaling, and cytochrome p450 activation...
  19. Stone M, Sharma A, Mas V, Gehrau R, Mulloy D, Zhao Y, et al. Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death. Transplantation. 2015;99:2494-503 pubmed publisher
    ..ATL1223 including the downregulation of genes involved in IL-1 signaling, such as ADCY9, ECSIT, IRAK1, MAPK12, and TOLLIP. Ex vivo lung perfusion modulates proinflammatory genes and reduces pulmonary dysfunction, edema, and inflammation ..
  20. Agrawal V, Jaiswal M, Ilievski V, Beaman K, Jilling T, Hirsch E. Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. Biol Reprod. 2014;91:119 pubmed publisher
    ..primary response gene 88 (MyD88), but not an alternative adaptor, Toll/IL-1 receptor domain-containing adapter protein-inducing interferon-beta (TRIF)...
  21. Ryan J, Wu Q, Shoemaker R. Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin. BMC Med Genomics. 2015;8:15 pubmed publisher
    ..CD9, CD36, vWF and Factor XIII), adaptive immunity (HLA-DQB1, DQB2, IL18R1 and IL5RA) and innate immunity (GZMK, TOLLIP, SIGIRR and VIPR2), overlapping several areas shown to be disrupted in a mouse model of acute exposure to ..
  22. Bonaventura R, Zito F, Chiaramonte M, Costa C, Russo R. Nickel toxicity in P. lividus embryos: Dose dependent effects and gene expression analysis. Mar Environ Res. 2018;139:113-121 pubmed publisher
    ..DNA repair, Pl-XPB/ERCC3; a mitogen-activated protein kinase (MAPK), Pl-p38; an ER stress gene, Pl-grp78; an adapter protein, Pl-14-3-3ε; two markers of pigment cells, Pl-PKS1 and Pl-gcm...
  23. Che L, Hu L, Liu Y, Yan C, Peng X, Xu Q, et al. Dietary Nucleotides Supplementation Improves the Intestinal Development and Immune Function of Neonates with Intra-Uterine Growth Restriction in a Pig Model. PLoS ONE. 2016;11:e0157314 pubmed publisher
    ..05). Meanwhile, the down-regulation of innate immunity-related genes such as TOLLIP (P<0.05), TLR-9 (P = 0.08) and TLR-2 (P = 0.07) was observed in the ileum of IUGR relative to NBW piglets...
  24. Osman I, Poulose N, Ganapathy V, Segar L. High fructose-mediated attenuation of insulin receptor signaling does not affect PDGF-induced proliferative signaling in vascular smooth muscle cells. Eur J Pharmacol. 2016;791:703-710 pubmed publisher
    ..studies with high fructose (5-25mM) showed marked increases in IRS-1 serine phosphorylation, a key adapter protein in insulin receptor signaling...
  25. Schick J, Etschel P, Bailo R, Ott L, Bhatt A, Lepenies B, et al. Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids. Infect Immun. 2017;85: pubmed publisher
    ..strains directly bound to recombinant Mincle in vitro Macrophages deficient in Mincle or its adapter protein Fc receptor gamma chain (FcRγ) produced severely reduced amounts of granulocyte colony-stimulating factor (G-..
  26. Rahimifard M, Maqbool F, Moeini Nodeh S, Niaz K, Abdollahi M, Braidy N, et al. Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation. Ageing Res Rev. 2017;36:11-19 pubmed publisher
    ..b>Toll interacting protein expression could be modulated by epigallocatechin-3-gallate...
  27. Shah J, Berrington W, Vary J, Wells R, Peterson G, Kunwar C, et al. Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist. J Infect Dis. 2016;213:1189-97 pubmed publisher
    ..Toll-interacting protein (TOLLIP) regulates Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling against mycobacteria...
  28. Williams K, McCann E, Fifita J, Zhang K, Duncan E, Leo P, et al. Novel TBK1 truncating mutation in a familial amyotrophic lateral sclerosis patient of Chinese origin. Neurobiol Aging. 2015;36:3334.e1-3334.e5 pubmed publisher
    ..L399fs) likely results in a truncated protein that lacks functional domains required for adapter protein binding, as well as protein activation and structural integrity...
  29. Gupta S, Termini J, Issac B, Guirado E, Stone G. Constitutively Active MAVS Inhibits HIV-1 Replication via Type I Interferon Secretion and Induction of HIV-1 Restriction Factors. PLoS ONE. 2016;11:e0148929 pubmed publisher
    ..understand interferon-mediated HIV-1 restriction, we constructed a constitutively active form of the RIG-I adapter protein MAVS...
  30. Hu L, Peng X, Chen H, Yan C, Liu Y, Xu Q, et al. Effects of intrauterine growth retardation and Bacillus subtilis PB6 supplementation on growth performance, intestinal development and immune function of piglets during the suckling period. Eur J Nutr. 2017;56:1753-1765 pubmed publisher
    ..The results of this study indicate that IUGR delayed growth, intestinal development and immune function of piglets, while FORM-BsPB6 improved digestive capability and intestinal barrier function. ..
  31. Mahakur S, Saikia B, Minz M, Minz R, Nada R, Anand S, et al. Allo-specific immune response profiles indicative of acute rejection in kidney allografts using an in vitro lymphocyte culture-based model. Clin Exp Nephrol. 2018;22:465-473 pubmed publisher
    ..On linear discriminant analysis and multivariate analysis of variance, a gene set comprising C3, CCL3, IL1B, TOLLIP, IL10, CXCL5, ABCF1, CCR3, IL10RB, CXCL1, and IL1R1 differentiated the ACR-AMR from the SA group...
  32. Bier D, Mittal S, Bravo Rodriguez K, Sowislok A, Guillory X, Briels J, et al. The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J Am Chem Soc. 2017;139:16256-16263 pubmed publisher
    ..Janus" ligand can bind simultaneously to a flexible peptidic PPI recognition motif and to a well-structured adapter protein. This binding fills a gap in the protein-protein interface, "freezes" one of the conformational states of the ..
  33. Liu Y, Chen M, Cheng L, Zhang Z, Yu Z, Jiang Q, et al. microRNA-200a downregulation in human glioma leads to Gαi1 over-expression, Akt activation, and cell proliferation. Oncogene. 2018;37:2890-2902 pubmed publisher
    ..cells and tissues, show that Gαi1 forms a complex with multiple RTKs (EGFR, PDGFRα, and FGFR) and the adapter protein Gab1...
  34. Fan P, McDaniel R, Kim H, Clagett D, Haddad B, Jordan V. Modulating therapeutic effects of the c-Src inhibitor via oestrogen receptor and human epidermal growth factor receptor 2 in breast cancer cell lines. Eur J Cancer. 2012;48:3488-98 pubmed publisher
    c-Src is an important adapter protein with oestrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2), which validates it as an attractive target for the treatment of breast cancer...
  35. Kim S, Park M, Yu H. Toll-Like Receptor Gene Expression during Trichinella spiralis Infection. Korean J Parasitol. 2015;53:431-8 pubmed publisher
    ..88 (MyD88)/TIR-associated proteins (TIRAP) and Toll receptor-associated activator of interferons (TRIF) adapter protein deficient and wild type (WT) mice...
  36. Ji H, Li B, Zhang S, He Z, Zhou Y, Ouyang L. Crk-like adapter protein is overexpressed in cervical carcinoma, facilitates proliferation, invasion and chemoresistance, and regulates Src and Akt signaling. Oncol Lett. 2016;12:3811-3817 pubmed
    Overexpression of Crk-like (CrkL) adapter protein has been implicated in a number of types of human cancer. However, its involvement in human cervical carcinoma remains unclear...
  37. Olivos D, Alvarez M, Cheng Y, Hooker R, Ciovacco W, Bethel M, et al. Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype. J Cell Biochem. 2017;118:2231-2240 pubmed publisher
    The Lnk adapter protein negatively regulates the signaling of thrombopoietin (TPO), the main megakaryocyte (MK) growth factor. Lnk-deficient (-/-) mice have increased TPO signaling and increased MK number...
  38. Argyris P, Gopalakrishnan R, Hu Y, REICHENBERGER E, Koutlas I. Clinicopathologic and Molecular Characteristics of Familial Cherubism with Associated Odontogenic Tumorous Proliferations. Head Neck Pathol. 2018;12:136-144 pubmed publisher
    ..a rare autosomal dominant condition affecting the jaws and caused by mutations in the gene encoding for the adapter protein SH3BP2 that maps to chromosome 4p16.3...
  39. Lányi Ã, Baráth M, Péterfi Z, Bogel G, Orient A, Simon T, et al. The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading. PLoS ONE. 2011;6:e23653 pubmed publisher
    ..of these sub-cellular structures is complex and relatively poorly understood, we evaluated the role of the adapter protein SH3PXD2B [HOFI, fad49, Tks4], which plays a role in the development of the eye, skeleton and adipose tissue...
  40. Mukherjee S, Biswas T. Activation of TOLLIP by porin prevents TLR2-associated IFN-γ and TNF-α-induced apoptosis of intestinal epithelial cells. Cell Signal. 2014;26:2674-82 pubmed publisher
    ..TLR2 expression is central for checking apoptosis which is achieved by elevated level of toll-interacting protein (TOLLIP) in presence of porin...
  41. Xiao S, Brannon M, Zhao X, Fread K, Ellena J, Bushweller J, et al. Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism. Structure. 2015;23:1910-1920 pubmed publisher
    Early endosomes represent the first sorting station for vesicular ubiquitylated cargo. Tollip, through its C2 domain, associates with endosomal phosphatidylinositol 3-phosphate (PtdIns(3)P) and binds ubiquitylated cargo in these ..
  42. Abdul Cader M, Amarasinghe A, Abdul Careem M. Activation of toll-like receptor signaling pathways leading to nitric oxide-mediated antiviral responses. Arch Virol. 2016;161:2075-86 pubmed publisher
    ..various TLR pathways can promote iNOS production via the myeloid differentiation primary response-88 (MyD-88) adapter protein. Subsequently, iNOS facilitates production of nitric oxide (NO), a highly reactive and potent antiviral ..
  43. Chang C, Bijian K, Qiu D, Su J, Saad A, Dahabieh M, et al. Endosomal sorting and c-Cbl targeting of paxillin to autophagosomes regulate cell-matrix adhesion turnover in human breast cancer cells. Oncotarget. 2017;8:31199-31214 pubmed publisher
    ..In this study, we uncovered an essential role of Y118 site-specific tyrosine phosphorylation of paxillin, an adapter protein of focal adhesion complexes, in paxillin recruitment to autophagosomes to trigger turnover of peripheral ..
  44. Li A, Guo X, Liu Y, Yang Y, Xu T, An S. [Structure and function of the adapter protein Gab and its role in the development of tumor, inflammation and cardiovascular diseases]. Sheng Li Xue Bao. 2016;68:57-64 pubmed
    ..In this review, we provide an overview of the structure and function of the scaffolding adapter, Gab, with a special focus on its role in tumor, inflammation and cardiovascular diseases. ..
  45. Byun E, Jang B, Kim H, Yang M, Sung N, Byun E. Gamma irradiation enhanced Tollip-mediated anti-inflammatory action through structural modification of quercetin in lipopolysaccharide-stimulated macrophages. Int Immunopharmacol. 2017;42:157-167 pubmed publisher
    ..and gamma-irradiated quercetin on the production of IL-6 and TNF-? was not observed in the down-regulation of Tollip. Therefore, these findings represent new insights into the understanding of the changes in molecular structure and ..
  46. Haas T, Heidegger S, Wintges A, Bscheider M, Bek S, Fischer J, et al. Card9 controls Dectin-1-induced T-cell cytotoxicity and tumor growth in mice. Eur J Immunol. 2017;47:872-879 pubmed publisher
    ..CTL cross-priming in mice does not require inflammasome activation but strictly depends on the adapter protein Card9 in vitro...
  47. Swindell W, Beamer M, Sarkar M, Loftus S, Fullmer J, Xing X, et al. RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature. Front Immunol. 2018;9:80 pubmed publisher
    ..Inactivation of MyD88 adapter protein using CRISPR/Cas9 completely abolished expression responses of such DEGs to IL-1B and IL-36G stimulation...
  48. Dai C, Sun L, Yu L, Zhu G, Wu S, Bao W. Effects of porcine MyD88 knockdown on the expression of TLR4 pathway-related genes and proinflammatory cytokines. Biosci Rep. 2016;36: pubmed publisher
    As a critical adapter protein in Toll-like receptor (TLR)/Interleukin (IL)-1R signalling pathway, myeloid differentiation protein 88 (MyD88) plays an important role in immune responses and host defence against pathogens...
  49. Backer M, Backer J. A "Dock and Lock" Approach to Preparation of Targeted Liposomes. Methods Mol Biol. 2017;1522:83-92 pubmed
    We developed a strategy for covalent coupling of targeting proteins to liposomes decorated with a standard adapter protein. This strategy is based on "dock and lock" interactions between two mutated fragments of human RNase I, a 1-15 aa ..
  50. Kumazoe M, Yamashita M, Nakamura Y, Takamatsu K, Bae J, Yamashita S, et al. Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression. J Immunol. 2017;199:3261-3269 pubmed publisher
    ..show that the green tea polyphenol epigallocatechin-3-O-gallate (EGCG) increases the expression of Toll interacting protein, a strong inhibitor of TLR4 signaling, by suppressing the expression of E74-like ETS transcription factor ..
  51. Sarvestani S, McAuley J. The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infection. Antiviral Res. 2017;148:32-42 pubmed publisher
    ..protein such as the nucleotide-binding oligomerization domain (NOD) like receptor proteins (NLRP), and an adapter protein, ASC, which critically activates pro-caspase-1...
  52. Yagasaki Y, Sudo T, Osada H. Exip, a splicing variant of p38alpha, participates in interleukin-1 receptor proximal complex and downregulates NF-kappaB pathway. FEBS Lett. 2004;575:136-40 pubmed
    ..Here we report that Exip, but not p38alpha, binds to Toll interacting protein which is involved in interleukin-1 (IL-1) signaling pathway as a component of the receptor proximal ..
  53. Lee H, Chung K. PINK1 positively regulates IL-1?-mediated signaling through Tollip and IRAK1 modulation. J Neuroinflammation. 2012;9:271 pubmed publisher
    ..PINK1 specifically binds two components of the IL-1-mediated signaling cascade, Toll-interacting protein (Tollip) and IL-1 receptor-associated kinase 1 (IRAK1)...
  54. Lin J, Hu G, Yu C, Li S, Liu Q, Zhang S. Molecular cloning and expression studies of the adapter molecule myeloid differentiation factor 88 (MyD88) in turbot (Scophthalmus maximus). Dev Comp Immunol. 2015;52:166-71 pubmed publisher
    Myeloid differentiation factor 88 (MyD88) is an adapter protein involved in the interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR)-mediated activation of nuclear factor-kappaB (NF-κB)...
  55. Makioka K, Yamazaki T, Takatama M, Ikeda M, Murayama S, Okamoto K, et al. Immunolocalization of Tom1 in relation to protein degradation systems in Alzheimer's disease. J Neurol Sci. 2016;365:101-7 pubmed publisher
    ..Moreover, in DNs, Tom1 colocalized with ubiquitin, lysosomal proteins, and Tom1-related proteins (Tollip and myosin VI), which act in both protein-degradation systems via Tom1...
  56. Gao S, Wang J, Zhang T, Liu G, Jin L, Ji D, et al. Low Expression of CAPON in Glioma Contributes to Cell Proliferation via the Akt Signaling Pathway. Int J Mol Sci. 2016;17: pubmed
    CAPON is an adapter protein for nitric oxide synthase 1 (NOS1). CAPON has two isoforms in the human brain: CAPON-L (long form of CAPON) and CAPON-S (short form of CAPON)...
  57. Wang J, Hanada K, Staus D, Makara M, Dahal G, Chen Q, et al. Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. Nat Commun. 2017;8:1706 pubmed publisher
    ..binding not only initiates G protein-mediated signaling but also signaling through the multifunctional adapter protein β-arrestin...
  58. Bai X, Yang X, Li J, Ye Li -, Jia X, Xiong Z, et al. Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-?B/Sp1 loop. Oncotarget. 2017;8:103985-103995 pubmed publisher
    ..Specifically, the organization and functions of caveolae are mediated by structure protein (caveolin-1) and adapter protein (cavin-1)...
  59. Carrasco K, Boufenzer A, Jolly L, Le Cordier H, Wang G, Heck A, et al. TREM-1 multimerization is essential for its activation on monocytes and neutrophils. Cell Mol Immunol. 2019;16:460-472 pubmed publisher
    ..We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization...
  60. Cianfanelli V, De Zio D, Di Bartolomeo S, Nazio F, Strappazzon F, Cecconi F. Ambra1 at a glance. J Cell Sci. 2015;128:2003-8 pubmed publisher
    ..also known as autophagy/Beclin-1 regulator 1, is a highly intrinsically disordered and vertebrate-conserved adapter protein that is part of the autophagy signaling network...
  61. Zhao Y, Ma C, Wu L, Iwai K, Ashwell J, Oltz E, et al. CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis. J Biol Chem. 2015;290:22076-84 pubmed publisher
    ..Therefore, our data demonstrate an unexpected non-catalytic function for CYLD as an adapter protein between TRAF2 and the NEMO zinc finger that is important for TNF-induced NF-κB signaling during ..
  62. He M, Ichinose T, Song Y, Yoshida Y, Kobayashi F, Maki T, et al. The Role of Toll-Like Receptors and Myeloid Differentiation Factor 88 in Bjerkandera adusta-Induced Lung Inflammation. Int Arch Allergy Immunol. 2015;168:96-106 pubmed publisher
    ..These results suggest that TLR2 and the adapter protein MyD88 may play an important role in the induction of eosinophils by B. adusta...
  63. Vaez H, Rameshrad M, Najafi M, Barar J, Barzegari A, Garjani A. Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like receptor 4 (TLR4) in heart. Eur J Pharmacol. 2016;772:115-23 pubmed publisher
    ..001) in the metformin group while the content of TLRs adapter protein of MyD88 was reduced by 45% (P<0.05)...
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    b>Tollip is a ubiquitously expressed protein, originally described as a modulator of the IL-1R/TLR-NF-κB signaling pathways...
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    ..These findings indicate that TRAF proteins may function as signal transducers for distinct receptor families and that TRAF6 participates in IL-1 signalling. ..
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    ..in IBD is currently unknown, and therefore we investigated the expression of TLR-8 and its natural antagonist, Tollip, in normal and inflamed human gut, and examined whether the receptor is functionally active...
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    ..We report here that Tollip, an adaptor protein that contains both ubiquitin-associated domains and endosome-targeting domain, plays an ..
  71. Peljto A, Selman M, Kim D, Murphy E, Tucker L, Pardo A, et al. The MUC5B promoter polymorphism is associated with idiopathic pulmonary fibrosis in a Mexican cohort but is rare among Asian ancestries. Chest. 2015;147:460-464 pubmed publisher
    Polymorphisms in the MUC5B promoter, TOLLIP, and nine additional genetic loci have been associated with idiopathic pulmonary fibrosis (IPF) within non-Hispanic white populations...
  72. Espada J, Martin Perez J. An Update on Src Family of Nonreceptor Tyrosine Kinases Biology. Int Rev Cell Mol Biol. 2017;331:83-122 pubmed publisher
    ..Through their common modular kinase an adapter protein domains, SFKs critically contribute to diversify different signal inputs, weaving a complex and dynamic ..
  73. Spolverini A, Fuchs G, Bublik D, Oren M. let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery. Oncogene. 2017;36:5819-5828 pubmed publisher
    ..let-7c bind directly and inhibit the mRNAs encoding the DUBs USP42 and USP44, and also the mRNA encoding the adapter protein ATXN7L3, which is part of the DUB module of the SAGA complex...
  74. Honda A, Usui H, Sakimura K, Igarashi M. Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity. J Biol Chem. 2017;292:20936-20946 pubmed publisher
    RUN and FYVE domain-containing 3 (Rufy3) is an adapter protein for small GTPase proteins and is bound to activated Rap2, a Ras family protein in the developing neuron...
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    ..We have previously shown that the GAT domain of Tom1 interacts with Tollip (Toll-interacting protein), which is associated with endosomes, to which it recruits Tom1...
  76. Li M, Feng B, Wang L, Guo S, Zhang P, Gong J, et al. Tollip is a critical mediator of cerebral ischaemia-reperfusion injury. J Pathol. 2015;237:249-62 pubmed publisher
    ..Toll-interacting protein (Tollip) is an endogenous negative modulator of TLR signalling that is involved in several inflammatory diseases...
  77. de Araujo F, da Silva L, Mesquita T, Pinheiro S, Vital W, Chrusciak Talhari A, et al. Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil. PLoS Negl Trop Dis. 2015;9:e0003875 pubmed publisher
    ..The Toll-interacting protein (TOLLIP) regulates human Toll-like receptors signaling pathways by down regulating the proinflammatory cytokines ..
  78. Stokes A, Shimoda L, Koblan Huberson M, Adra C, Turner H. A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. J Exp Med. 2004;200:137-47 pubmed
    ..we describe a novel protein kinase A (PKA)-dependent signaling module, containing PKA and a putative A kinase adapter protein, Acyl CoA binding domain protein (ACBD)3, that interacts with TRPV2 in mast cells...
  79. Cheerathodi M, Avci N, Guerrero P, Tang L, Popp J, Morales J, et al. The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma. Mol Cancer Res. 2016;14:1277-1287 pubmed
    ..Tumor cell invasion is a major clinical obstacle in glioblastoma and this study identifies a new signaling pathway regulated by Spinophilin in invasive glioblastoma. Mol Cancer Res; 14(12); 1277-87. ©2016 AACR. ..
  80. Franklin B, Latz E, Schmidt F. The intra- and extracellular functions of ASC specks. Immunol Rev. 2018;281:74-87 pubmed publisher
    ..On the molecular level, this is accomplished by the sensor-nucleated recruitment and oligomerization of the adapter protein ASC...
  81. Rao N, Nguyen S, Ngo K, Fung Leung W. A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol Cell Biol. 2005;25:6521-32 pubmed
    ..However, IRAK1c retains the ability to strongly interact with IRAK2, MyD88, Tollip, and TRAF6...
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    ..The Toll-like receptor 2 (TLR2) and Toll-interacting protein (TOLLIP) are important in recognition and regulation of human innate immunity response to S. aureus...
  83. Cai T, Sun D, Duan Y, Qiu Y, Dai C, Yang J, et al. FHL2 promotes tubular epithelial-to-mesenchymal transition through modulating ?-catenin signalling. J Cell Mol Med. 2017;: pubmed publisher
    ..As an adapter protein, four and a half LIM domain protein 2 (FHL2) acts as a coregulator of ?-catenin in several other cell types...
  84. Huang Z, Yi X, Chen Y, Hou X, Wang X, Zhu P, et al. Pretreatment of Pam3CSK4 attenuates inflammatory responses caused by systemic infection of methicillin-resistant Staphylococcus aureus in mice. Biomed Pharmacother. 2017;95:1684-1692 pubmed publisher
    ..the TLR2 expression was down-regulated, IRAK1 phosphorylation was inhibited, and the expression of IRAK-M and Tollip, two negative regulators of NF-?B pathway, was up-regulated...
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    Toll-interacting protein (Tollip) is an endogenous inhibitor of toll-like receptors, a superfamily that plays a pivotal role in various pathological conditions, including myocardial infarction (MI)...
  86. Yang F, Kuang W, Li C, Sun W, Qu D, Wang J. Toll-Interacting Protein Suppresses HIV-1 Long-Terminal-Repeat-Driven Gene Expression and Silences the Post-Integrational Transcription of Viral Proviral DNA. PLoS ONE. 2015;10:e0125563 pubmed publisher
    Toll-interacting protein (Tollip) is a host adaptor protein for negatively regulating Toll-like receptor 2-, 4-, and IL-1R (interleukin-1 receptor)-mediated signaling...
  87. Fakhri D, Djauzi S, Murni T, Rachmat J, Harahap A, Rahayuningsih S, et al. Genetic polymorphism in postoperative sepsis after open heart surgery in infants. Asian Cardiovasc Thorac Ann. 2016;24:326-31 pubmed publisher
    ..504), while toll-interacting protein rs5743867 polymorphism tends to decrease the risk of sepsis (odds ratio?=?0.496; 95% confidence interval: 0.19-1.27; p?=?0.139) in infants <1-year old undergoing complex open heart surgery. ..
  88. Goloviznina N, Verghese S, Yoon Y, Taratula O, Marks D, Kurre P. Mesenchymal Stromal Cell-derived Extracellular Vesicles Promote Myeloid-biased Multipotent Hematopoietic Progenitor Expansion via Toll-Like Receptor Engagement. J Biol Chem. 2016;291:24607-24617 pubmed
    ..Our studies reveal that HSPC expansion by MSC EVs is mediated via the MyD88 adapter protein and is partially blocked by treatment with a TLR4 inhibitor...
  89. Xu M, Liu B, Wang C, Wang G, Tian Y, Wang S, et al. Epigallocatechin-3-gallate inhibits TLR4 signaling through the 67-kDa laminin receptor and effectively alleviates acute lung injury induced by H9N2 swine influenza virus. Int Immunopharmacol. 2017;52:24-33 pubmed publisher
    ..Lung physiopathology, inflammation, oxidative stress, viral replication, and TLR4/NF-?B/Toll-interacting protein (Tollip) pathway in lung tissue and/or PMVECs were investigated...
  90. Jamalpour M, Li X, Cavelier L, Gustafsson K, Mostoslavsky G, Höglund M, et al. Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia. Tumour Biol. 2017;39:1010428317720643 pubmed publisher
    The mouse Shb gene coding for the Src Homology 2-domain containing adapter protein B has recently been placed in context of BCRABL1-induced myeloid leukemia in mice and the current study was performed in order to relate SHB to human ..
  91. Oldham J, Noth I, Martinez F. Pharmacogenetics and interstitial lung disease. Curr Opin Pulm Med. 2016;22:456-65 pubmed publisher
    ..A recent pharmacogenetic analysis of patients enrolled in an IPF clinical trial identified a variant within TOLLIP to be associated with differential response to N-acetylcysteine therapy...
  92. Ankem G, Mitra S, Sun F, Moreno A, Chutvirasakul B, Azurmendi H, et al. The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides. Biochem J. 2011;435:597-608 pubmed publisher
    ..b>Tollip (Toll-interacting protein) modulates IRAK function in the TLR signalling pathway...