Gene Symbol: TOB2
Description: transducer of ERBB2, 2
Alias: APRO5, TOB4, TOBL, TROB2, protein Tob2, protein Tob4, transducer of erbB-2 2
Species: human
Products:     TOB2

Top Publications

  1. Yu B, Peng X, Zhao F, Liu X, Lu J, Wang L, et al. MicroRNA-378 functions as an onco-miR in nasopharyngeal carcinoma by repressing TOB2 expression. Int J Oncol. 2014;44:1215-22 pubmed publisher
    ..investigations revealed that miR-378 overexpression was able to downregulate the expression of transducer of ERBB2 (TOB2), a potential tumor suppressor, and miR-378 silencing enhanced TOB2 expression...
  2. Chen Y, Wang C, Wu J, Li L. BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation. Biochem Biophys Res Commun. 2015;462:208-14 pubmed publisher
    ..ability, and there are six members including BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. Among them, Tob subfamily members, specifically Tob1/Tob and Tob2, have the most extensive C-terminal regions...
  3. Ge Y, Li J, Hao Y, Hu Y, Chen D, Wu B, et al. MicroRNA-543 functions as an osteogenesis promoter in human periodontal ligament-derived stem cells by inhibiting transducer of ERBB2, 2. J Periodontal Res. 2018;53:832-841 pubmed publisher
    ..The transducer of ERBB2, 2 (TOB2) was identified as a target gene of miR-543 and luciferase report revealed that miR-543 interacts directly with the ..
  4. Tanaka W, Toriba T, Hirano H. Three TOB1-related YABBY genes are required to maintain proper function of the spikelet and branch meristems in rice. New Phytol. 2017;215:825-839 pubmed publisher
    ..We focused on three rice (Oryza sativa) YABBY genes, TONGARI-BOUSHI (TOB1, TOB2, TOB3), which are closely related to Arabidopsis (Arabidopsis thaliana) FILAMENTOUS FLOWER (FIL)...
  5. Wang H, Cui Y, Luan J, Zhou X, Li C, Li H, et al. MiR-5100 promotes osteogenic differentiation by targeting Tob2. J Bone Miner Metab. 2017;35:608-615 pubmed publisher
    ..Target prediction analysis and experimental validation demonstrated that Tob2, which acts as a negative regulator of osteogenesis, was negatively regulated by miR-5100...
  6. Shen H, Li W, Tian Y, Xu P, Wang H, Zhang J, et al. Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma. J Cell Biochem. 2015;116:1563-73 pubmed publisher
    ..growth and its expression inhibition had opposing effects that were associated with regulation of its direct target-Tob2 in HCC cells...
  7. Li C, Wang Y, Lin Z, Yang L, Gao S, Liu T, et al. MiR-5100 targets TOB2 to drive epithelial-mesenchymal transition associated with activating smad2/3 in lung epithelial cells. Am J Transl Res. 2017;9:4694-4706 pubmed
    ..Using target prediction software and luciferase reporter assays, we identified TOB2 as a specific target of miR-5100 and miR-5100 can decrease the accumulation of endogenous TOB2 in A549 and Beas-2B ..
  8. Mirza Z, Rajeh N. Identification Of Electrophysiological Changes In Alzheimer's Disease: A Microarray Based Transcriptomics And Molecular Pathway Analysis Study. CNS Neurol Disord Drug Targets. 2017;: pubmed publisher
    ..05 and 2 fold change. Transducer of ERBB2, 2 (TOB2); lactotransferrin (LFT) and RAS-like, family 12 (RASL12) were most up-regulated genes, while neurofilament light ..
  9. Ikematsu N, Yoshida Y, Kawamura Tsuzuku J, Ohsugi M, Onda M, Hirai M, et al. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. Oncogene. 1999;18:7432-41 pubmed
    ..The putative protein product termed Tob2 consisted of 344 amino acids with high similarity to the Tob protein. The tob2 mRNA was 4...

More Information


  1. Jin Y, Birlea S, Fain P, Ferrara T, Ben S, Riccardi S, et al. Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. Nat Genet. 2012;44:676-80 pubmed publisher
    ..56 × 10(-8)), CD44 (P = 1.78 × 10(-9)), IKZF4 (P = 2.75 × 10(-14)), SH2B3 (P = 3.54 × 10(-18)) and TOB2 (P = 6.81 × 10(-10))...
  2. Rivas M, Tkach M, Beguelin W, Proietti C, Rosemblit C, Charreau E, et al. Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation. Breast Cancer Res Treat. 2010;122:111-24 pubmed publisher
    ..As TNFalpha has been shown to be present in the tumor microenvironment of a significant proportion of human infiltrating breast cancers, our findings would have clinical implication in ErbB-2-positive breast cancer treatment. ..
  3. Ezzeddine N, Chang T, Zhu W, Yamashita A, Chen C, Zhong Z, et al. Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation. Mol Cell Biol. 2007;27:7791-801 pubmed
    ..Our findings reveal a new mechanism by which the fate of mammalian mRNA is modulated at the deadenylation step by a protein that recruits poly(A) nuclease(s) to the 3' poly(A) tail-PABP complex. ..
  4. Yoshida Y, Hosoda E, Nakamura T, Yamamoto T. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. Jpn J Cancer Res. 2001;92:592-6 pubmed
    A 35-kDa protein, ANA, belongs to an emerging family of antiproliferative proteins consisting of Tob, Tob2, ANA / BTG3, PC3B, PC3 / TIS21 / BTG2, and BTG1...
  5. Suzuki T, Matsuda S, Tsuzuku J, Yoshida Y, Yamamoto T. A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob. Genes Cells. 2001;6:131-8 pubmed
    ..Because p90rsk1 is activated downstream of receptor tyrosine kinases, we propose that Tob function is at least in part under the control of growth factor-stimulated tyrosine kinases through its phosphorylation by p90rsk1. ..
  6. An Q, Burke G, Dainton M, Harrison C, Kempski H, Konn Z, et al. Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy. Leukemia. 2010;24:649-52 pubmed publisher
  7. Chen C, Zheng D, Xia Z, Shyu A. Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps. Nat Struct Mol Biol. 2009;16:1160-6 pubmed publisher
    ..These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs. ..
  8. Huang Y, Zheng J, Tan T, Song L, Huang S, Zhang Y, et al. BTG1 low expression in pancreatic ductal adenocarcinoma is associated with a poorer prognosis. Int J Biol Markers. 2017;: pubmed publisher
    BTG1 is a member of the TOB/BTG protein family, which is a transducer of ErbB-2 and TOB2. It is known to inhibit tumor genesis, but its role in pancreatic ductal adenocarcinoma (PDAC) is still unknown...
  9. Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. DNA Res. 2001;8:1-9 pubmed
    ..In conclusion, the mapping of ESTs derived from long cDNAs followed by sequencing of the entire cDNAs provided indispensable information for the precise annotation of genes on the genome together with ESTs derived from short cDNAs. ..
  10. Feng M, Li Z, Aau M, Wong C, Yang X, Yu Q. Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation. Oncogene. 2011;30:2242-51 pubmed publisher
    ..this oncogenic effect, at least in part, by targeting and inhibiting the anti-proliferative BTG family member, TOB2, which is further elucidated as a candidate tumor suppressor to transcriptionally repress proto-oncogene cyclin D1...
  11. Huang K, Chadee A, Chen C, Zhang Y, Shyu A. Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate. RNA. 2013;19:295-305 pubmed publisher
    ..The results indicate that changing the extent of phosphorylation of three PAM2-containing proteins (Tob2, Pan3, and Tnrc6c) alters their ability to interact with PABPC1...
  12. Sasajima H, Nakagawa K, Yokosawa H. Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. Eur J Biochem. 2002;269:3596-604 pubmed
    ..Here, we report that BTG1, Tob, and Tob2 proteins, as well as BTG2 protein, are degraded by the ubiquitin-proteasome system; the degradation of Tob protein ..
  13. Juszczak G, Stankiewicz A. Glucocorticoids, genes and brain function. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:136-168 pubmed publisher
    ..Cxxc5, Litaf, Tle4, Jun, Sox4, Sox2, Sox9, Irf1, Sall2, Nfkbia and Id1) and the selective degradation of mRNA (Tob2)...
  14. Su H, Meng S, Lu Y, Trombly M, Chen J, Lin C, et al. Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing. Mol Cell. 2011;43:97-109 pubmed publisher
    ..Among the PABC-interactors, DDX6 and Tob1/2 are both required and sufficient for silencing mRNA targets. Taken together, these data demonstrate a critical function for EDD in miRNA silencing. ..
  15. Ezzeddine N, Chen C, Shyu A. Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities. Mol Cell Biol. 2012;32:1089-98 pubmed publisher
    The mammalian TOB1 and TOB2 proteins have emerged as key players in repressing cell proliferation. Accumulating evidence indicates that TOBs regulate mRNA deadenylation...