Gene Symbol: TNPO1
Description: transportin 1
Alias: IPO2, KPNB2, MIP, MIP1, TRN, transportin-1, M9 region interaction protein, importin 2, importin beta 2, karyopherin (importin) beta 2, karyopherin beta-2
Species: human
Products:     TNPO1

Top Publications

  1. Pollard V, Michael W, Nakielny S, Siomi M, Wang F, Dreyfuss G. A novel receptor-mediated nuclear protein import pathway. Cell. 1996;86:985-94 pubmed
    ..Furthermore, as hnRNP A1 likely participates in mRNA export, it raises the possibility that transportin is a mediator of this process as well. ..
  2. Bukrinsky M, Sharova N, Dempsey M, Stanwick T, Bukrinskaya A, Haggerty S, et al. Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Proc Natl Acad Sci U S A. 1992;89:6580-4 pubmed
  3. Moroianu J, Hijikata M, Blobel G, Radu A. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proc Natl Acad Sci U S A. 1995;92:6532-6 pubmed
    ..In an overlay assay with SDS/PAGE-resolved and nitrocellulose-transferred proteins of the nuclear envelope, 35S-labeled karyopherin beta bound to at least four peptide repeat-containing nucleoporins--Nup358, Nup214, Nup153, and Nup98. ..
  4. Fridell R, Truant R, Thorne L, Benson R, Cullen B. Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta. J Cell Sci. 1997;110 ( Pt 11):1325-31 pubmed
    ..Here, we report the identification of a novel human protein, termed MIP, that binds M9 specifically both in vivo and in vitro yet fails to interact with non-functional M9 point mutants...
  5. Bukrinsky M, Haffar O. HIV-1 nuclear import: in search of a leader. Front Biosci. 1997;2:d578-87 pubmed
    ..We also describe a class of novel anti-HIV compounds which target the NLSs of HIV-1 and effectively block viral replication in T cells and macrophages. ..
  6. Vodicka M, Koepp D, Silver P, Emerman M. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes Dev. 1998;12:175-85 pubmed
    ..Our data suggest Vpr functionally resembles importin-beta in nuclear import of the HIV-1 pre-integration complex and this function is essential for the role of Vpr in macrophage infection, but not G2 arrest. ..
  7. Popov S, Rexach M, Zybarth G, Reiling N, Lee M, Ratner L, et al. Viral protein R regulates nuclear import of the HIV-1 pre-integration complex. EMBO J. 1998;17:909-17 pubmed
    ..These results identify the biochemical mechanism of Vpr function in transport of the viral pre-integration complex to, and across, the nuclear membrane. ..
  8. Fouchier R, Meyer B, Simon J, Fischer U, Albright A, Gonzalez Scarano F, et al. Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex. J Virol. 1998;72:6004-13 pubmed
    ..These findings not only demonstrate that Vpr harbors a bona fide NLS but also raise the possibility that one (or more) of Vpr's functions may take place at the NPC. ..
  9. Jenkins Y, McEntee M, Weis K, Greene W. Characterization of HIV-1 vpr nuclear import: analysis of signals and pathways. J Cell Biol. 1998;143:875-85 pubmed
    ..Rather, this viral protein appears to directly access the NPC, a property that may help to ensure the capacity of HIV to replicate in nondividing cellular hosts. ..

More Information

Publications113 found, 100 shown here

  1. Bachi A, Braun I, Rodrigues J, Pante N, Ribbeck K, von Kobbe C, et al. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA. 2000;6:136-58 pubmed
  2. Rebane A, Aab A, Steitz J. Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. RNA. 2004;10:590-9 pubmed
    ..Previously, Transportin 1 (Trn1) was identified as a mediator of hnRNP A1 import, whereas the closely related protein Transportin 2 (..
  3. Cansizoglu A, Lee B, Zhang Z, Fontoura B, Chook Y. Structure-based design of a pathway-specific nuclear import inhibitor. Nat Struct Mol Biol. 2007;14:452-4 pubmed
    ..On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M. ..
  4. Imasaki T, Shimizu T, Hashimoto H, Hidaka Y, Kose S, Imamoto N, et al. Structural basis for substrate recognition and dissociation by human transportin 1. Mol Cell. 2007;28:57-67 pubmed
    b>Transportin 1 (Trn1) is a transport receptor that transports substrates from the cytoplasm to the nucleus through nuclear pore complexes by recognizing nuclear localization signals (NLSs)...
  5. Van Dusen C, Yee L, McNally L, McNally M. A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1. Mol Cell Biol. 2010;30:2552-62 pubmed publisher
    ..S-transferase (GST) pulldown assays demonstrated that the hnRNP H NLS interacts with the import receptor transportin 1. Finally, we show that hnRNP H/F are transcription-dependent shuttling proteins...
  6. Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, et al. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J. 2010;29:2841-57 pubmed publisher
    ..We propose that two pathological hits, namely nuclear import defects and cellular stress, are involved in the pathogenesis of FUS-opathies. ..
  7. Bukrinsky M, Haggerty S, Dempsey M, Sharova N, Adzhubel A, Spitz L, et al. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature. 1993;365:666-9 pubmed
  8. Michael W, Choi M, Dreyfuss G. A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell. 1995;83:415-22 pubmed
    ..These findings demonstrate that there is a signal-dependent, temperature-sensitive nuclear export pathway and strengthen the suggestion that A1 and other shuttling hnRNPs function as carriers for RNA during export to the cytoplasm. ..
  9. Nakielny S, Siomi M, Siomi H, Michael W, Pollard V, Dreyfuss G. Transportin: nuclear transport receptor of a novel nuclear protein import pathway. Exp Cell Res. 1996;229:261-6 pubmed
    ..Transportin relatives from Saccharomyces cerevisiae which likely serve as additional nuclear transport receptors are described. ..
  10. Gallay P, Hope T, Chin D, Trono D. HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. Proc Natl Acad Sci U S A. 1997;94:9825-30 pubmed
    ..This novel function of integrase reflects the recognition of an atypical bipartite nuclear localization signal by the importin/karyopherin pathway. ..
  11. Siomi M, Eder P, Kataoka N, Wan L, Liu Q, Dreyfuss G. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol. 1997;138:1181-92 pubmed
    ..Thus, it is likely that after nuclear import, A1 dissociates from transportin1 by RanGTP and becomes incorporated into hnRNP complexes, where A1 functions in pre-mRNA processing. ..
  12. Popov S, Rexach M, Ratner L, Blobel G, Bukrinsky M. Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex. J Biol Chem. 1998;273:13347-52 pubmed
    ..Vpr stabilized docking by preventing nucleoporin-stimulated dissociation of the import complex. These results suggest a biochemical mechanism for Vpr function in transport of the HIV-1 genome across the nuclear pore complex. ..
  13. Chook Y, Blobel G. Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. Nature. 1999;399:230-7 pubmed
  14. Jans D, Jans P, Jülich T, Briggs L, Xiao C, Piller S. Intranuclear binding by the HIV-1 regulatory protein VPR is dependent on cytosolic factors. Biochem Biophys Res Commun. 2000;270:1055-62 pubmed
  15. Mazzio E, Li N, Bauer D, Mendonça P, Taka E, Darb M, et al. Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis. BMC Complement Altern Med. 2016;16:467 pubmed
    ..The data show that activated BV-2 microglia cells (+ LPS 1?g/ml) release >10-fold greater IL-6, MIP1/2, RANTES and nitric oxide (NO2-), where RAW 264...
  16. Mazzio E, Bauer D, Mendonça P, Taka E, Soliman K. Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells. J Neuroimmunol. 2017;302:10-19 pubmed publisher the following, IL-13, TNF-a, fracktaline, leptin, LIX, GM-CSF, ICAM1, L-Selectin, activin A, agrin, IL-1α, MIP-3a, B72/CD86, NGF, IL-1b, MMP-8, IL-1 R6, PDGF-AA, IL-2, IL-4, prolactin R, RAGE, IL-6, Thymus Chemokine-1, CNTF,IL-..
  17. Tao G, Pan L, Jing R, Lin F, Dai H, Ge W. [Study on Rac1/MAPK/ERK pathway mediated mechanism and role in rats with ventilator induced lung injury]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:249-254 pubmed publisher
    ..IL-1β, IL-6), tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) and macrophage inflammatory protein-2 (MIP-2) in serum and BALF were determined by enzyme linked immunosorbent assay (ELISA)...
  18. Kiang J, Smith J, Anderson M, Elliott T, Gupta P, Balakathiresan N, et al. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE. 2017;12:e0184393 pubmed publisher
    ..increase of IL-1, IL-2, IL-3, IL-5, IL-6, IL-12, IL-13, IL-15, IL-17A, IL-18, G-CSF, CM-CSF, eotaxin, IFN-?, MCP-1, MIP, RANTES, and TNF-?, which were all increased by hemorrhage alone, except IL-9, IL-17A, and MCP-1...
  19. Tong F, Zhang H. Pulmonary Exposure to Particulate Matter (PM2.5) Affects the Sensitivity to Myocardial Ischemia/Reperfusion Injury Through Farnesoid-X-Receptor-Induced Autophagy. Cell Physiol Biochem. 2018;46:1493-1507 pubmed publisher
    ..autophagosomes, microtubule-associated protein 1 light chain 3 (LC-I and II), macrophage inflammatory protein-2 (MIP-2) and farnesoid-X-receptor (FXR) were determined in myocardial tissues via biochemical analysis, ..
  20. Liu Y, Li L, Fu J, Kao K, Huang C, Chien Y, et al. Induced pluripotent stem cell therapy ameliorates hyperoxia-augmented ventilator-induced lung injury through suppressing the Src pathway. PLoS ONE. 2014;9:e109953 pubmed publisher the increases in microvascular permeability, neutrophil infiltration, macrophage inflammatory protein-2 (MIP-2) and plasminogen activator inhibitor-1 (PAI-1) production, Src activation, nicotinamide adenine dinucleotide ..
  21. Sun B, Li X, Zheng G, Dong T, Li Y, Li H, et al. [Blockade of programmed death-ligand 1 attenuates indirect acute lung injury in mice through targeting endothelial cells but not epithelial cells]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019;31:37-43 pubmed publisher
    ..levels such as interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2) and tumor necrosis factor-α (TNF-α) in lung tissue or plasma were significantly reduced following PD-L1 ..
  22. Dicks M, Betancor G, Jiménez Guardeño J, Pessel Vivares L, Apolonia L, Goujon C, et al. Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction. PLoS Pathog. 2018;14:e1007408 pubmed publisher
    ..FG) repeat containing cytoplasmic filament nucleoporin NUP214, and transport receptor transportin-1 (TNPO1) were consistently required for full MX2, and interferon-mediated, anti-viral function...
  23. Lee M, Jang M, Choi J, Chang B, Kim D, Kim S, et al. Korean Red Ginseng and Ginsenoside-Rb1/-Rg1 Alleviate Experimental Autoimmune Encephalomyelitis by Suppressing Th1 and Th17 Cells and Upregulating Regulatory T Cells. Mol Neurobiol. 2016;53:1977-2002 pubmed publisher
    ..IL]-1β), chemokines (RANTES, monocyte chemotactic protein-1 [MCP-1], and macrophage inflammatory protein-1α [MIP-1α]), adhesion molecules (intercellular adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1],..
  24. Leonhardt I, Spielberg S, Weber M, Albrecht Eckardt D, Bläss M, Claus R, et al. The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. MBio. 2015;6:e00143 pubmed publisher
    ..of proinflammatory cytokines (tumor necrosis factor alpha [TNF-α] and macrophage inflammatory protein 1 alpha [MIP-1α]). However, this activation did not result in enhanced fungal uptake or killing...
  25. Zhang Y, Guo H, Cheng B, Su T, Fu X, Li T, et al. Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells. Drug Des Devel Ther. 2018;12:2731-2748 pubmed publisher
    ..chemoattractant protein-1 [MCP-1], chemokine [C-C motif] ligand 5 [CCL-5], and macrophage inflammatory protein [MIP]-1α) were suppressed by DCEO treatment...
  26. Tsirkone V, Blokken J, De Wit F, Breemans J, De Houwer S, Debyser Z, et al. N-terminal half of transportin SR2 interacts with HIV integrase. J Biol Chem. 2017;292:9699-9710 pubmed publisher
    The karyopherin transportin SR2 (TRN-SR2, TNPO3) is responsible for shuttling specific cargoes such as serine/arginine-rich splicing factors from the cytoplasm to the nucleus...
  27. Pell C, Straus L, Andrew E, Meñaca A, Pool R. Social and cultural factors affecting uptake of interventions for malaria in pregnancy in Africa: a systematic review of the qualitative research. PLoS ONE. 2011;6:e22452 pubmed publisher
    Malaria during pregnancy (MiP) results in adverse birth outcomes and poor maternal health...
  28. Dietsch G, Randall T, Gottardo R, Northfelt D, Ramanathan R, Cohen P, et al. Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337). Clin Cancer Res. 2015;21:5445-52 pubmed publisher
    ..In late-stage cancer patients, plasma levels of multiple biomarkers, including IL6, G-CSF, MCP-1, and MIP1-β, increased with increasing motolimod dose...
  29. Nguyen Hoai T, Pham Duc M, Gries M, Dorken B, Pezzutto A, Westermann J. CCL4 as an adjuvant for DNA vaccination in a Her2/neu mouse tumor model. Cancer Gene Ther. 2016;23:162-7 pubmed publisher
    ..Chemokines are key regulators of both innate and adaptive immune responses. CCL4 (macrophage inflammatory protein-1?, MIP-1?) is a CC chemokine that has a broad spectrum of target cells including immature dendritic cells, which express ..
  30. de Almeida S, Rotta I, Jiang Y, Li X, Raboni S, Ribeiro C, et al. Biomarkers of chemotaxis and inflammation in cerebrospinal fluid and serum in individuals with HIV-1 subtype C versus B. J Neurovirol. 2016;22:715-724 pubmed
    ..None had opportunistic infections. Chemokines (MCP-1, MIP-1α, MIP-1β, RANTES, IP-10) and cytokines (TNF-α, IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10) were ..
  31. Giribaldi G, Valente E, Khadjavi A, Polimeni M, Prato M. Macrophage inflammatory protein-1alpha mediates matrix metalloproteinase-9 enhancement in human adherent monocytes fed with malarial pigment. Asian Pac J Trop Med. 2011;4:925-30 pubmed publisher
    To investigate the role of macrophage inflammatory protein-1alpha (MIP-1alpha) in the detrimental enhancement of matrix metalloproteinase-9 (MMP-9) expression, release and activity induced by phagocytosis of malarial pigment (haemozoin, ..
  32. Takeuchi A, Eto M, Tatsugami K, Shiota M, Yamada H, Kamiryo Y, et al. Antitumor activity of recombinant Bacille Calmette-Guérin secreting interleukin-15-Ag85B fusion protein against bladder cancer. Int Immunopharmacol. 2016;35:327-331 pubmed publisher
    ..of neutrophils was significantly elevated in BCGB-IL-15 treated mice accompanied by increased chemokines (MIP-2 and MIP-1?) in the bladder. Thus, BCG-IL-15 exerted additive effect on Infiltration of neutrophils in the bladder...
  33. Hassanzadeh M, Ghaemy M, Ahmadi S. Extending Time Profile of Morphine-Induced Analgesia Using a Chitosan-Based Molecular Imprinted Polymer Nanogel. Macromol Biosci. 2016;16:1515-1523 pubmed publisher
    Chitosan-based molecular imprinted polymer (CS-MIP) nanogel is prepared in the presence of morphine template, fully characterized and used as a new vehicle to extend duration of morphine analgesic effect in Naval Medical Research ..
  34. Shamsher M, Ploski J, Radu A. Karyopherin beta 2B participates in mRNA export from the nucleus. Proc Natl Acad Sci U S A. 2002;99:14195-9 pubmed
    ..The data support the conclusion that Kap beta2B participates directly in the export of a large proportion of cellular mRNAs, and TAP connects Kap beta2B to the mRNAs to be exported. ..
  35. Edsfeldt A, Grufman H, Asciutto G, Nitulescu M, Persson A, Nilsson M, et al. Circulating cytokines reflect the expression of pro-inflammatory cytokines in atherosclerotic plaques. Atherosclerosis. 2015;241:443-9 pubmed publisher
    ..Plasma levels of macrophage inflammatory protein-1β (MIP-1β), tumor necrosis factor- α (TNF-α) and fractalkine correlated significantly, not only with plaque ..
  36. van Lelyveld S, Drylewicz J, Krikke M, Veel E, Otto S, Richter C, et al. Maraviroc Intensification of cART in Patients with Suboptimal Immunological Recovery: A 48-Week, Placebo-Controlled Randomized Trial. PLoS ONE. 2015;10:e0132430 pubmed publisher
    ..did increase the percentage of CCR5 expressing CD4+ and CD8+ T-cells, and the plasma levels of the CCR5 ligand MIP-1β. In contrast, the percentage of ex-vivo apoptotic CD8+ and CD4+ T-cells decreased in the maraviroc arm...
  37. Pouwels S, Buise M, Smeenk F, Teijink J, Nienhuijs S. Comparative analysis of respiratory muscle strength before and after bariatric surgery using 5 different predictive equations. J Clin Anesth. 2016;32:172-80 pubmed publisher
    ..Patients scheduled for elective bariatric surgery. Bariatric surgery. The maximal inspiratory pressure (MIP) was measured at screening and 3, 6, and 9 months postoperative...
  38. Munoz J, Martin R, Alonso C, Gutierrez B, Nieto M. Relation between serum levels of chemotaxis-related factors and the presence of coronary artery calcification as expression of subclinical atherosclerosis. Clin Biochem. 2017;: pubmed publisher
    ..Chemotaxis-related proteins, including netrin-1, gremlin-1 and macrophage inflammatory protein-1? (MIP-1?), regulate immune cell migration...
  39. Gao L, Han W, Li X, Wang J, Yan Y, Li C, et al. Detection of λ-cyhalothrin by a core-shell spherical SiO2-based surface thin fluorescent molecularly imprinted polymer film. Anal Bioanal Chem. 2015;407:9177-84 pubmed publisher
    ..Therefore this study demonstrated the potential of MIP for the recognition and detection of LC in food.
  40. Seo K, Choi J, Kim D, Han D, Noh S, Jung H. Aminophylline Effect on Renal Ischemia-Reperfusion Injury in Mice. Transplant Proc. 2017;49:358-365 pubmed publisher
    ..tumor necrosis factor-? (TNF-?), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), and intercellular adhesion molecule-1 (ICAM-1) mRNA were significantly increased in group C (P < .001)...
  41. Yu Y, Li X, Qiu L, Guo J, Yang D, Guo Y. [Effects of lipopolysaccharides from Porphyromonas endodontalis on the expression of MIP-1α in mouse osteoblasts]. Shanghai Kou Qiang Yi Xue. 2017;26:263-267 pubmed
    ..e) on the expression of macrophageinflammatoryprotein-1α (MIP-1α) mRNA and protein levels in MC3T3-E1 cells and the influence of curcumin in the process...
  42. Singh B, Saqib M, Gupta A, Kumar P, Bhaskar S. Autophagy induction by Mycobacterium indicus pranii promotes Mycobacterium tuberculosis clearance from RAW 264.7 macrophages. PLoS ONE. 2017;12:e0189606 pubmed publisher
    Mycobacterium indicus pranii (MIP) is a potent vaccine candidate against tuberculosis (TB) as it has demonstrated significant protection in animal models of tuberculosis as well as in clinical trials...
  43. Chegou N, Sutherland J, Namuganga A, Corstjens P, Geluk A, Gebremichael G, et al. Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis. Sci Rep. 2018;8:2675 pubmed publisher
    ..5%) had ORD and 61(11.5%) had an uncertain diagnosis. A biosignature comprising unstimulated IFN-γ, MIP-1β, TGF-α and antigen-specific levels of TGF-α and VEGF, identified on a training sample set (n =â..
  44. Choi H, Roh D, Yoon S, Kwon S, Choi S, Kang S, et al. The role of spinal interleukin-1? and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model. Exp Neurol. 2016;: pubmed publisher
    ..IL)-1?, which inhibits spinal astrocyte activation and results in the delayed development of Mirror-Image Pain (MIP), little is known regarding the mechanisms that underlie how spinal IL-1? inhibits the astrocyte activation...
  45. Pena Philippides J, Caballero Garrido E, Lordkipanidze T, Roitbak T. In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response. J Neuroinflammation. 2016;13:287 pubmed
    ..and CXCL3 cytokine expression at 7 days and significantly increased levels of major cytokines IL-10, IL-4, IL-6, MIP-1α, IL-5, and IL-17 at 14 days after dMCAO...
  46. Wang X, Wu X, Liu G, Lin H, Wang X. The assembly of thiophene-based bis-pyridyl-bis-amide CoII coordination polymers and their polypyrrole-functionalized hybrid materials for boosting their photocatalytic performances. Dalton Trans. 2016;45:19341-19350 pubmed
    ..ligand and different polycarboxylates, namely, [Co(3-bptpa)(1,3-BDC)]·2H2O (CP1), [Co(3-bptpa)(5-MIP)]·2H2O (CP2), [Co(3-bptpa)(1,3,5-HBTC)] (CP3), [Co(3-bptpa)(5-NIP)]·2H2O (CP4) and [Co(3-..
  47. Huang W, Huang C, Chang C, Kor C, Chen T, Wu H. Associations of Self-Reported Sleep Quality with Circulating Interferon Gamma-Inducible Protein 10, Interleukin 6, and High-Sensitivity C-Reactive Protein in Healthy Menopausal Women. PLoS ONE. 2017;12:e0169216 pubmed publisher
    ..with interferon gamma-inducible protein-10 (IP10), interleukin 6 (IL6), and macrophage inflammatory protein-1beta (MIP-1?) levels...
  48. Ohya T, Hagiwara M, Chino K, Suzuki Y. Maximal inspiratory mouth pressure in Japanese elite female athletes. Respir Physiol Neurobiol. 2017;238:55-58 pubmed publisher
    Maximal inspiratory mouth pressure (MIP) is a common measurement of inspiratory muscle strength, which is often used in a variety of exercises to evaluate the effects of inspiratory muscle training...
  49. Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, et al. Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. Exp Dermatol. 2017;26:868-874 pubmed publisher
    ..tissues and serum and in the mRNA levels of HDC, a histamine-producing enzyme, macrophage inflammatory protein-2 (MIP-2), a chemoattractant for neutrophils, and monocyte chemoattractant protein-1 (MCP-1), a chemoattractant for ..
  50. Purohit S, Sharma A, Hopkins D, Steed L, Bode B, Anderson S, et al. Large-Scale Discovery and Validation Studies Demonstrate Significant Reductions in Circulating Levels of IL8, IL-1Ra, MCP-1, and MIP-1β in Patients With Type 1 Diabetes. J Clin Endocrinol Metab. 2015;100:E1179-87 pubmed publisher
    ..40; P = 5.7 × 10(-19); IL-1Ra: OR = 0.42; P = 1.1 × 10(-13); MCP-1: OR = 0.60; P = 6.7 × 10(-9); and MIP-1β: OR = 0.63; P = 4.2 × 10(-7))...
  51. Raymond G, Pasquali M, Polgreen L, Dickson P, Miller W, Orchard P, et al. Elevated cerebral spinal fluid biomarkers in children with mucopolysaccharidosis I-H. Sci Rep. 2016;6:38305 pubmed publisher CSF of children with MPS-IH showed significantly elevated inflammatory markers including: MCP-1 SDF-1a, IL-Ra, MIP-1b, IL-8, and VEGF in comparison to unaffected children...
  52. Chen H, Singh R, Lu X, Huo L, Yao H, Aldape K, et al. Genome-wide copy number aberrations and HER2 and FGFR1 alterations in primary breast cancer by molecular inversion probe microarray. Oncotarget. 2017;8:10845-10857 pubmed publisher
    ..To identify novel prognostic biomarkers in breast cancer, we used molecular inversion probe (MIP) microarray to explore genome-wide copy number aberrations (CNA) and breast cancer-related gene alterations in DNA ..
  53. Idica A, Sevrioukov E, Zisoulis D, Hamdorf M, Daugaard I, Kadandale P, et al. MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1. J Biol Chem. 2017;292:20494-20508 pubmed publisher
    ..We found that miR-128 targets the 3' UTR of nuclear import factor transportin 1 (TNPO1) mRNA...
  54. Rodrigues G, Gurgel J, Gonçalves T, da Silva Soares P. Inspiratory muscle training improves physical performance and cardiac autonomic modulation in older women. Eur J Appl Physiol. 2018;118:1143-1152 pubmed publisher
    ..One group underwent IMT set at 50% of maximum inspiratory pressure (MIP), every day for 4 weeks (IMT-group)...
  55. Ahmed A, Koma M. Interleukin-33 Triggers B1 Cell Expansion and Its Release of Monocyte/Macrophage Chemoattractants and Growth Factors. Scand J Immunol. 2015;82:118-24 pubmed publisher also mediates monocyte/macrophage and granulocyte recruitment via B1 cell release of chemokines (MCP-1 and MIP-1 alpha)...
  56. Yamakawa M, Ouhara K, Kajiya M, Munenaga S, Kittaka M, Yamasaki S, et al. Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice. Clin Exp Immunol. 2016;186:177-189 pubmed publisher
    ..ACPA, MMP-3, interleukin (IL)-2, IL-6, CXCL1 and macrophage inflammatory protein (MIP)-1? levels from the Pg/LA group were the highest. The osteoclastogenesis of BMCs was enhanced in the Pg/LA group...
  57. Chen C, Chen J, Chen H, Chai J, Chen P, Chen C. Patterns of cerebrospinal fluid (CSF) distribution in patients with spontaneous intracranial hypotension: Assessed with magnetic resonance myelography. J Chin Med Assoc. 2017;80:109-116 pubmed publisher of CSF distribution were used to evaluate the three-dimensional maximum intensity projection (3D MIP) and the thin-slice axial multiplanar reconstruction (MPR) images, respectively...
  58. Athale S, Banchereau R, Thompson Snipes L, Wang Y, Palucka K, Pascual V, et al. Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets. Sci Transl Med. 2017;9: pubmed publisher
    ..factor, and the chemokines IFN-γ-inducible protein 10 (IP-10) and macrophage inflammatory protein-1β (MIP-1β). Conversely, MIV-09 did not induce the production of type I IFNs in moDCs and blood cDCs...
  59. Trivedi M, Mondal S, Gangwar M, Jana S. Immunomodulatory potential of nanocurcumin-based formulation. Inflammopharmacology. 2017;25:609-619 pubmed publisher
    ..The proinflammatory cytokines (TNF-?, IL-1?, and MIP-1?) and NK cells' activity were measured in cell supernatants using ELISA assay; however, phagocytosis activity was ..
  60. Ao J, Gu J, Yuan T, Li D, Ma Y, Shen Z. Applying molecular modelling and experimental studies to develop molecularly imprinted polymer for domoic acid enrichment from both seawater and shellfish. Chemosphere. 2018;199:98-106 pubmed publisher
    A highly selective sample cleanup method using molecularly imprinted polymers (MIP) was developed for the enrichment of domoic acid (DA, an amnesic shellfish toxin) from both seawater and shellfish samples...
  61. Fronz K, Güttinger S, Burkert K, Kuhn U, Stöhr N, Schierhorn A, et al. Arginine methylation of the nuclear poly(a) binding protein weakens the interaction with its nuclear import receptor, transportin. J Biol Chem. 2011;286:32986-94 pubmed publisher
    ..In the nucleus, arginine methylation may favor the transition of PABPN1 to the competing ligand RNA and serve to reduce the risk of the protein being reexported to the cytoplasm by transportin. ..
  62. Bushehri A, Czarnota G, Zhang L, Hynynen K, Huang Y, Chan M, et al. Urinary cytokines/chemokines after magnetic resonance-guided high intensity focused ultrasound for palliative treatment of painful bone metastases. Ann Palliat Med. 2017;6:36-54 pubmed publisher
    ..Nine urinary cytokines significantly decreased post MRgHIFU, namely, eotaxin, GRO, IL-8, IL-13, IP-10, MCP-1, MIP-1?, RANTES, and sIL-2R?...
  63. Byrne D, Sugrue G, Stanley E, Walsh J, Murphy S, Kavanagh E, et al. Improved Detection of Anterior Circulation Occlusions: The "Delayed Vessel Sign" on Multiphase CT Angiography. AJNR Am J Neuroradiol. 2017;38:1911-1916 pubmed publisher
    ..001) with multiphase CTA compared with single-phase CTA. Readers preferred MIP images compared with source images in >90% of cases...
  64. Gu X, Chen W, You J, Koretsky A, Volkow N, Pan Y, et al. Long-term optical imaging of neurovascular coupling in mouse cortex using GCaMP6f and intrinsic hemodynamic signals. Neuroimage. 2018;165:251-264 pubmed publisher
    ..calcium indicator with optical techniques, we develop a longitudinal multimodal optical imaging platform (MIP) that enabled time-lapse tracking of NVC over a relatively large field of view in the mouse somatosensory cortex at ..
  65. Kluijfhout W, Vorselaars W, Vriens M, Borel Rinkes I, Valk G, de Keizer B. Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT-CT, ultrasound and first results of (18)F-fluorocholine PET-CT. Eur J Radiol. 2015;84:1745-51 pubmed publisher order to create a more efficient diagnostic pathway and enable minimal invasive parathyroidectomy (MIP) in patients with biochemical proven non-familial primary hyperparathyroidism (pHPT)...
  66. Liu J, Tang K, Qiu Q, Pan D, Lei Z, Xing F. Experimental Investigation on Pore Structure Characterization of Concrete Exposed to Water and Chlorides. Materials (Basel). 2014;7:6646-6659 pubmed publisher
    ..of concrete exposed to deionised water and 5% NaCl solution was evaluated using mercury intrusion porosity (MIP), scanning electron microscopy (SEM) and X-ray diffraction (XRD)...
  67. Kim H, Kim H, Kim K, German M, Kim H. Ectopic serotonin production in β-cell specific transgenic mice. Biochem Biophys Res Commun. 2018;495:1986-1991 pubmed publisher
    ..Here, we showed the ectopic serotonin (5-HT) production in β-cells of RIP-CreMgn, MIP-GFP, and MIP-Cre/ERT mice...
  68. Kogan M, Rappaport J. HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention. Retrovirology. 2011;8:25 pubmed publisher
    ..In view of the pivotal functions of Vpr in virus infection, replication, and persistence of infection, this protein represents an attractive target for therapeutic intervention. ..
  69. Ørning P, Hoem K, Coron A, Skjåk Bræk G, Mollnes T, Brekke O, et al. Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation. J Control Release. 2016;229:58-69 pubmed publisher
    ..induction of the proinflammatory cytokines interleukin (IL-1)β, TNF, IL-6, the chemokines IL-8 (CXCL8), and MIP-1α (CCL3) and MCP-1(CCL2)...
  70. Conroy M, Galvin K, Kavanagh M, Mongan A, Doyle S, Gilmartin N, et al. CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer. Immunol Cell Biol. 2016;94:531-7 pubmed publisher
    ..The CCR5 ligand and inflammatory chemokine MIP-1? is also secreted at significantly higher concentrations in the omentum and liver of our OAC patient cohort ..
  71. Vincent M, Court Fortune I, Brun C, Camdessanche J, Verges S, Costes F. Determination of normal values for an isocapnic hyperpnea endurance test in healthy individuals. Respir Physiol Neurobiol. 2016;230:5-10 pubmed publisher
    ..We measured vital capacity (VC) and maximal respiratory pressure (MIP, MEP)...
  72. Himes J, Ho C, Nguyen Q, Amos J, Xu H, Chan C, et al. Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys. J Virol. 2016;90:8795-808 pubmed publisher
    ..We also assessed the cytokine milieu in SIV-infected AGM milk and compared it to that of SIV-infected RMs. MIP-1?, granulocyte colony-stimulating factor (G-CSF), interleukin-12/23 (IL-12/23), and IL-13 trended significantly ..
  73. Seufert F, Kuhn M, Hein M, Weiwad M, Vivoli M, Norville I, et al. Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei. Bioorg Med Chem. 2016;24:5134-5147 pubmed publisher
    ..As a virulence factor, the macrophage infectivity potentiator (Mip) protein constitutes an attractive target. The Mip proteins of B. pseudomallei and L...
  74. Li W, Chang N, Tian L, Yang J, Ji X, Xie J, et al. miR-27b-3p, miR-181a-1-3p, and miR-326-5p are involved in the inhibition of macrophage activation in chronic liver injury. J Mol Med (Berl). 2017;95:1091-1105 pubmed publisher
    ..15d-PGJ2 reduced activated BMM population in injured livers. Inflammatory cytokine expressions (MIP-1β, TNF-α, NOS2) were depressed by 15d-PGJ2 in macrophages isolated from treated livers...
  75. Warren M, Subramani K, Schwartz R, Raju R. Mitochondrial dysfunction in rat splenocytes following hemorrhagic shock. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2526-2533 pubmed publisher
    ..An increased inflammatory response was demonstrated by significantly increased expression of IL-6, IFN-β, Mip-1α, IL-10 and NFκbp65...
  76. Song H, Wang Y, Zhang L, Tian L, Luo J, Zhao N, et al. An ultrasensitive and selective electrochemical sensor for determination of estrone 3-sulfate sodium salt based on molecularly imprinted polymer modified carbon paste electrode. Anal Bioanal Chem. 2017;409:6509-6519 pubmed publisher
    ..Cyclic voltammetry was performed to the study preparation process and binding behavior of the MIP-modified CPE (MIP/CPE) toward ESS...
  77. Boland M, Miele E, Delude K. Relationship between Physiological Off-Ice Testing, On-Ice Skating, and Game Performance in Division I Women's Ice Hockey Players. J Strength Cond Res. 2017;: pubmed publisher
    ..lower body explosive power, anaerobic power, countermovement vertical jump (CMJ), maximum inspiratory pressure (MIP), and on-ice repeated skate sprint (RSS) performance. The on-ice RSS test included 6 timed 85...
  78. Silva C, Borges K, do Nascimento C. Rational design of a molecularly imprinted polymer for dinotefuran: theoretical and experimental studies aimed at the development of an efficient adsorbent for microextraction by packed sorbent. Analyst. 2017;143:141-149 pubmed publisher
    In this work, we studied theoretically the formation process of a molecularly imprinted polymer (MIP) for dinotefuran (DNF), testing distinct functional monomers (FM) in various solvents through density functional theory calculations...
  79. Shin N, Li Y, Mei S, Wang K, Hall L, Katiyar K, et al. INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies. J Pharmacol Exp Ther. 2018;364:120-130 pubmed publisher
    ..INCB040093 inhibits the production of macrophage-inflammatory protein-1β (MIP-1beta) and tumor necrosis factor-β (TNF-beta) from a B cell line, suggesting a potential effect on the ..
  80. Siomi M, Fromont M, Rain J, Wan L, Wang F, Legrain P, et al. Functional conservation of the transportin nuclear import pathway in divergent organisms. Mol Cell Biol. 1998;18:4141-8 pubmed
    ..We also report on additional substrates for TRN as well as sequences of Drosophila melanogaster, Xenopus laevis, and Schizosaccharomyces pombe TRNs...
  81. Nakielny S, Shaikh S, Burke B, Dreyfuss G. Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J. 1999;18:1982-95 pubmed
    We employed a phage display system to search for proteins that interact with transportin 1 (TRN1), the import receptor for shuttling hnRNP proteins with an M9 nuclear localization sequence (NLS), and identified a short region within the ..
  82. Bukrinsky M, Haffar O. HIV-1 nuclear import: in search of a leader. Front Biosci. 1999;4:D772-81 pubmed
    ..We also describe a class of novel anti-HIV compounds that target the NLSs of HIV-1 and effectively block viral replication in T cells and macrophages. ..
  83. Putker M, Madl T, Vos H, de Ruiter H, Visscher M, van den Berg M, et al. Redox-dependent control of FOXO/DAF-16 by transportin-1. Mol Cell. 2013;49:730-42 pubmed publisher
    ..This molecular mechanism for nuclear shuttling is conserved in C. elegans and directly connects redox signaling to the longevity protein FOXO/DAF-16...
  84. Wang F, Yang L, Shi L, Li Q, Zhang G, Wu J, et al. Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells. Oncotarget. 2015;6:21468-78 pubmed
    ..These findings demonstrated for the first time the molecular mechanisms for FGF2's nuclear import, which promotes GBM cell proliferation and survival, providing novel insights to the development of GBM treatments. ..
  85. Oderda M, Calleris G, Allasia M, Dalmasso E, Falcone M, Catti M, et al. Robot-assisted laparoscopic pyeloplasty in a pediatric patient with horseshoe kidney: surgical technique and review of the literature. Urologia. 2017;84:55-60 pubmed publisher
    ..HSK) through the report of our recent case, and to outline the state of the art of minimally invasive pyeloplasty (MIP) with a systematic review of the literature...
  86. Bucher K, Schmitt F, Mothes B, Blumendeller C, Schall D, Piekorz R, et al. Deficiency of PI3-Kinase catalytic isoforms p110? and p110? in mice enhances the IL-17/G-CSF axis and induces neutrophilia. Cell Commun Signal. 2017;15:28 pubmed publisher
    ..IL-17, of the neutrophilic growth factor G-CSF, and of the neutrophil mobilizing CXC chemokines CXCL1/KC and CXCL2/MIP-2 were measured by Bio-Plex assay...
  87. Stepanova M, Kinziabulatova L, Nikitina A, Korzhikova Vlakh E, Tennikova T. Cholesterol-imprinted macroporous monoliths: Preparation and characterization. Electrophoresis. 2017;38:2965-2974 pubmed publisher
    ..the maximum binding capacity, the number of theoretical plates and the height equivalent to a theoretical palate of MIP monoliths at different mobile phase flow rates were determined...
  88. Perin C, Meroni R, Rega V, Braghetto G, Cerri C. Parameters Influencing Tracheostomy Decannulation in Patients Undergoing Rehabilitation after severe Acquired Brain Injury (sABI). Int Arch Otorhinolaryngol. 2017;21:382-389 pubmed publisher
    ..cap, fenestration), SpO2, presentation and quantification of pulmonary secretion, maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP), respiratory frequency and pattern, cardiac frequency, presence of ..
  89. David J, Nandakumar A, Muniroh M, Akiba S, Yamamoto M, Koriyama C. Suppression of methylmercury-induced MIP-2 expression by N-acetyl-L-cysteine in murine RAW264.7 macrophage cell line. Eur J Med Res. 2017;22:45 pubmed publisher
    ..We focused on murine macrophage inflammatory protein-2 (MIP-2), keratinocyte chemoattractant (KC), and monocyte chemoattractant protein-5 (MCP-5)...
  90. Kourghi M, Pei J, De Ieso M, Nourmohammadi S, Chow P, Yool A. Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life. Clin Exp Pharmacol Physiol. 2017;: pubmed publisher
    Aquaporin (AQP) channels in the Major Intrinsic Protein (MIP) family are known to facilitate transmembrane water fluxes in prokaryotes and eukaryotes...
  91. Mercieca S, Belderbos J, De Jaeger K, Schinagl D, van der Voort Van Zijp N, Pomp J, et al. Interobserver variability in the delineation of the primary lung cancer and lymph nodes on different four-dimensional computed tomography reconstructions. Radiother Oncol. 2018;126:325-332 pubmed publisher
    ..GTVp) and lymph nodes (GTVln) between three different 4DCT reconstruction types; Maximum Intensity Projection (MIP), Mid-Ventilation (Mid-V) and Mid-Position (Mid-P)...
  92. Desai J, Sartor R, Lawas L, Jagadish S, Doherty C. Improving Gene Regulatory Network Inference by Incorporating Rates of Transcriptional Changes. Sci Rep. 2017;7:17244 pubmed publisher
    ..We have developed ExRANGES, an approach that improves the ability to computationally infer TRN from time series expression data...