TNNT2

Summary

Gene Symbol: TNNT2
Description: troponin T2, cardiac type
Alias: CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT, troponin T, cardiac muscle, cardiomyopathy, dilated 1D (autosomal dominant), cardiomyopathy, hypertrophic 2, troponin T type 2 (cardiac), truncated cardiac troponin T
Species: human
Products:     TNNT2

Top Publications

  1. Meune C, Balmelli C, Twerenbold R, Reiter M, Reichlin T, Ziller R, et al. Utility of 14 novel biomarkers in patients with acute chest pain and undetectable levels of conventional cardiac troponin. Int J Cardiol. 2013;167:1164-9 pubmed publisher
    ..We enrolled 1247 consecutive patients with suspected AMI. Of these, 325 had undetectable levels of cTnT (Roche, 4th generation assay) at presentation and at 6h...
  2. Song L, Zou Y, Wang J, Wang Z, Zhen Y, Lou K, et al. Mutations profile in Chinese patients with hypertrophic cardiomyopathy. Clin Chim Acta. 2005;351:209-16 pubmed
    ..patients with HCM (proband 51, sporadic 49) by sequencing the three most frequent HCM-causing genes (MYH7, MYBPC3, TNNT2)...
  3. Watkins H, McKenna W, Thierfelder L, Suk H, Anan R, O Donoghue A, et al. Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy. N Engl J Med. 1995;332:1058-64 pubmed
    ..These mutations are characterized by relatively mild and sometimes subclinical hypertrophy but a high incidence of sudden death. Genetic testing may therefore be especially important in this group. ..
  4. Erdmann J, Daehmlow S, Wischke S, Senyuva M, Werner U, Raible J, et al. Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy. Clin Genet. 2003;64:339-49 pubmed
    ..HCM patients for mutations in six sarcomeric genes: myosin-binding protein C3 (MYBPC3), MYH7, cardiac troponin T (TNNT2), alpha-tropomyosin (TPM1), cardiac troponin I (TNNI3), and cardiac troponin C (TNNC1)...
  5. Hershberger R, Pinto J, Parks S, Kushner J, Li D, Ludwigsen S, et al. Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy. Circ Cardiovasc Genet. 2009;2:306-13 pubmed publisher
    ..We recently undertook bidirectional resequencing of TNNT2, the cardiac troponin T gene, in 313 probands with DCM...
  6. Luedde M, Ehlermann P, Weichenhan D, Will R, Zeller R, Rupp S, et al. Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation. Cardiovasc Res. 2010;86:452-60 pubmed publisher
    ..Here, we describe a family with LVNC due to a novel missense mutation, pE96K, in the cardiac troponin T gene (TNNT2)...
  7. Li D, Czernuszewicz G, Gonzalez O, Tapscott T, Karibe A, Durand J, et al. Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy. Circulation. 2001;104:2188-93 pubmed
    ..Because several mutations in troponin T have already been recognized to be responsible for FHCM, it appears that the phenotype, whether it be hypertrophy or dilatation, is determined by the specific mutation rather than the gene. ..
  8. Wu A, Ford L. Release of cardiac troponin in acute coronary syndromes: ischemia or necrosis?. Clin Chim Acta. 1999;284:161-74 pubmed
    ..Jeopardized myocardial tissue can recover with acute recanalization. Support for this model comes from clinical observations and animal studies. ..
  9. Anan R, Shono H, Kisanuki A, Arima S, Nakao S, Tanaka H. Patients with familial hypertrophic cardiomyopathy caused by a Phe110Ile missense mutation in the cardiac troponin T gene have variable cardiac morphologies and a favorable prognosis. Circulation. 1998;98:391-7 pubmed
    ..Patients with mutations in the cardiac troponin T (cTnT) gene have particularly poor prognosis but only mild hypertrophy...

More Information

Publications76

  1. Moolman J, Corfield V, Posen B, Ngumbela K, Seidman C, Brink P, et al. Sudden death due to troponin T mutations. J Am Coll Cardiol. 1997;29:549-55 pubmed
    ..Because this is one of poor prognosis, despite deceptively mild or undetectable hypertrophy, genotyping at this locus may be particularly informative in patient management and counselling. ..
  2. Forissier J, Carrier L, Farza H, Bonne G, Bercovici J, Richard P, et al. Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy. Circulation. 1996;94:3069-73 pubmed
    ..In some families, the disease is linked to the CMH2 locus on chromosome 1q3, in which the cardiac troponin T gene (TNNT2) has been identified as the disease gene...
  3. Scherr J, Braun S, Schuster T, Hartmann C, Moehlenkamp S, Wolfarth B, et al. 72-h kinetics of high-sensitive troponin T and inflammatory markers after marathon. Med Sci Sports Exerc. 2011;43:1819-27 pubmed publisher
    ..Therefore, we investigated cardiac biomarkers (high-sensitive cardiac troponin T (hs-cTnT), N-terminal pro-brain natriuretic peptide (NT-proBNP), heart-type fatty acid-binding protein (h-FABP)), ..
  4. Millat G, Bouvagnet P, Chevalier P, Dauphin C, Jouk P, Da Costa A, et al. Prevalence and spectrum of mutations in a cohort of 192 unrelated patients with hypertrophic cardiomyopathy. Eur J Med Genet. 2010;53:261-7 pubmed publisher
    ..HCM patients using denaturing high-performance liquid chromatography/sequencing analysis of the MYBPC3, MYH7, TNNT2 and TNNI3 genes...
  5. Ingles J, Doolan A, Chiu C, Seidman J, Seidman C, Semsarian C. Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. J Med Genet. 2005;42:e59 pubmed
    ..Genetic screening of seven HCM genes (beta-MHC, MyBP-C, cTnT, cTnI, ACTC, MYL2, and MYL3) was undertaken in 80 unrelated probands...
  6. Marsiglia J, Credidio F, de Oliveira T, Reis R, Antunes M, de Araujo A, et al. Screening of MYH7, MYBPC3, and TNNT2 genes in Brazilian patients with hypertrophic cardiomyopathy. Am Heart J. 2013;166:775-82 pubmed publisher
    ..We amplified the coding sequencing of MYH7, MYBPC3, and TNNT2 genes and sequenced them with an automatic sequencer. We identified causal mutations in 131 patients (48.8%)...
  7. Revera M, van der Merwe L, Heradien M, Goosen A, Corfield V, Brink P, et al. Troponin T and beta-myosin mutations have distinct cardiac functional effects in hypertrophic cardiomyopathy patients without hypertrophy. Cardiovasc Res. 2008;77:687-94 pubmed
    ..Individuals aged 20-65 belonging to 21 R92W(TNNT2), R403W(MYH7), or A797T(MYH7) mutation-bearing families were investigated with 2D, M-mode, and Doppler ..
  8. Rani D, Nallari P, Dhandapany P, Tamilarasi S, Shah A, Archana V, et al. Cardiac Troponin T (TNNT2) mutations are less prevalent in Indian hypertrophic cardiomyopathy patients. DNA Cell Biol. 2012;31:616-24 pubmed publisher
    We sought to determine the frequency of the genetic variations in the Troponin T (TNNT2) gene and its association in Indian cardiomyopathy patients...
  9. Satyan S, Light R, Agarwal R. Relationships of N-terminal pro-B-natriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients. Am J Kidney Dis. 2007;50:1009-19 pubmed
    Although the cardiac biomarker troponin T (cTnT) is related strongly to mortality in patients with end-stage renal disease, the independent association of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and cTnT levels in ..
  10. Liu B, Tikunova S, Kline K, Siddiqui J, Davis J. Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. PLoS ONE. 2012;7:e38259 pubmed publisher
    ..Troponin C may act as a hub, sensing physiological and pathological stimuli to modulate the Ca(2+)-binding properties of the thin filament and influence the contractile performance of the heart. ..
  11. Pasquale F, Syrris P, Kaski J, Mogensen J, McKenna W, Elliott P. Long-term outcomes in hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene. Circ Cardiovasc Genet. 2012;5:10-7 pubmed publisher
    Hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene (TNNT2) has been associated with a high risk of sudden cardiac death (SCD) and mild left ventricular hypertrophy...
  12. Pinto J, Parvatiyar M, Jones M, Liang J, Potter J. A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin. J Biol Chem. 2008;283:2156-66 pubmed
    ..We are reporting the functional effects of the first cardiac troponin T (CTnT) mutation linked to infantile RCM resulting from a de novo deletion mutation of glutamic acid 96...
  13. Brekke P, Omland T, Holmedal S, Smith P, Søyseth V. Troponin T elevation and long-term mortality after chronic obstructive pulmonary disease exacerbation. Eur Respir J. 2008;31:563-70 pubmed
    ..Median observation time was 1.9 yrs. In 396 patients, measurements of cardiac-specific troponin T (cTnT) were available. Levels of cTnT >/=0.04 mug.L(-1) were considered elevated...
  14. Breidthardt T, Burton J, Odudu A, Eldehni M, Jefferies H, McIntyre C. Troponin T for the detection of dialysis-induced myocardial stunning in hemodialysis patients. Clin J Am Soc Nephrol. 2012;7:1285-92 pubmed publisher
    ..03 ng/ml at baseline versus 0.05 ng/ml at year 1). Troponin T levels in HD patients are associated with the presence and severity of HD-induced myocardial stunning. ..
  15. Menon S, Michels V, Pellikka P, Ballew J, Karst M, Herron K, et al. Cardiac troponin T mutation in familial cardiomyopathy with variable remodeling and restrictive physiology. Clin Genet. 2008;74:445-54 pubmed publisher
    ..Linkage to eight genes was excluded, but a cardiac troponin T (TNNT2) marker cosegregated with the disease phenotype...
  16. Ackerman M, VanDriest S, Ommen S, Will M, Nishimura R, Tajik A, et al. Prevalence and age-dependence of malignant mutations in the beta-myosin heavy chain and troponin T genes in hypertrophic cardiomyopathy: a comprehensive outpatient perspective. J Am Coll Cardiol. 2002;39:2042-8 pubmed
    ..In the cardiac troponin T gene (TNNT2), a specific mutation (R92W) has been associated with high risk of sudden death...
  17. Redwood C, Lohmann K, Bing W, Esposito G, Elliott K, Abdulrazzak H, et al. Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein. Circ Res. 2000;86:1146-52 pubmed
    ..Further, these findings underscore the importance of studying mixed mutant:wild-type preparations to faithfully model this autosomal-dominant disease. ..
  18. Mogensen J, Murphy R, Shaw T, Bahl A, Redwood C, Watkins H, et al. Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 2004;44:2033-40 pubmed
    We performed genetic investigations of cardiac troponin T (TNNT2) and troponin C (TNNC1) in 235 consecutive patients with idiopathic dilated cardiomyopathy (DCM) to evaluate prevalence of mutations and associated disease expression in ..
  19. Garcia Castro M, Reguero J, Batalla A, Diaz Molina B, Gonzalez P, Alvarez V, et al. Hypertrophic cardiomyopathy: low frequency of mutations in the beta-myosin heavy chain (MYH7) and cardiac troponin T (TNNT2) genes among Spanish patients. Clin Chem. 2003;49:1279-85 pubmed
    Mutations in the cardiac beta-myosin heavy chain (MYH7) and cardiac troponin T (TNNT2) genes are reportedly responsible for up to 40% of familial cases with hypertrophic cardiomyopathy (HC)...
  20. Hernandez O, Szczesna Cordary D, Knollmann B, Miller T, Bell M, Zhao J, et al. F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers. J Biol Chem. 2005;280:37183-94 pubmed
    ..The combination of increased Ca(2+) sensitivity and energy cost in the F110I hearts may be responsible for the greater severity of this phenotype compared with the R278C mutation. ..
  21. Van Driest S, Ackerman M, Ommen S, Shakur R, Will M, Nishimura R, et al. Prevalence and severity of "benign" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy. Circulation. 2002;106:3085-90 pubmed
    ..survival: N232S, G256E, F513C, V606M, R719Q, and L908V of beta-myosin heavy chain (MYH7); S179F of troponin T (TNNT2); and D175N of alpha-tropomyosin (TPM1)...
  22. Townsend P, Farza H, MacGeoch C, Spurr N, Wade R, Gahlmann R, et al. Human cardiac troponin T: identification of fetal isoforms and assignment of the TNNT2 locus to chromosome 1q. Genomics. 1994;21:311-6 pubmed
    ..Hybridization of the cloned cDNAs to genomic DNA identifies a single-copy gene, and using somatic cell hybrid analysis, we have mapped the corresponding gene locus (designated TNNT2) to the long arm of chromosome 1 (1cen-qter).
  23. Saunders J, Nambi V, de Lemos J, Chambless L, Virani S, Boerwinkle E, et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation. 2011;123:1367-76 pubmed publisher
    We evaluated whether cardiac troponin T (cTnT) measured with a new highly sensitive assay was associated with incident coronary heart disease (CHD), mortality, and hospitalization for heart failure (HF) in a general population of ..
  24. Gomes A, Barnes J, Harada K, Potter J. Role of troponin T in disease. Mol Cell Biochem. 2004;263:115-29 pubmed publisher
    ..To date 30 mutations have been identified in the cardiac TnT (CTnT) gene that results in familial HCM (FHC)...
  25. Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, et al. The role of a common TNNT2 polymorphism in cardiac hypertrophy. J Hum Genet. 2004;49:129-33 pubmed
    We found a five-basepair insertion/deletion polymorphism in intron 3 of TNNT2, one of the genes responsible for hypertrophic cardiomyopathy...
  26. Richard P, Charron P, Carrier L, Ledeuil C, Cheav T, Pichereau C, et al. Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. Circulation. 2003;107:2227-32 pubmed
    ..The entire coding sequences of 9 genes (MYH7, MYBPC3, TNNI3, TNNT2, MYL2, MYL3, TPM1, ACTC, andTNNC1) were analyzed in 197 unrelated index cases with familial or sporadic ..
  27. Mirza M, Marston S, Willott R, Ashley C, Mogensen J, McKenna W, et al. Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype. J Biol Chem. 2005;280:28498-506 pubmed
  28. Haaf P, Drexler B, Reichlin T, Twerenbold R, Reiter M, Meissner J, et al. High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease. Circulation. 2012;126:31-40 pubmed publisher
    ..In a prospective, international multicenter study, hs-cTn was measured with 3 assays (hs-cTnT, Roche Diagnostics; hs-cTnI, Beckman-Coulter; hs-cTnI Siemens) in a blinded fashion at presentation and serially ..
  29. Nakajima Taniguchi C, Matsui H, Fujio Y, Nagata S, Kishimoto T, Yamauchi Takihara K. Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy. J Mol Cell Cardiol. 1997;29:839-43 pubmed
    ..for HCM in HCM families have been identified as beta-myosin heavy chain, alpha-tropomyosin, cardiac troponin T (cTnT) and myosin binding protein-C genes...
  30. Ho C, Lever H, DeSanctis R, Farver C, Seidman J, Seidman C. Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy. Circulation. 2000;102:1950-5 pubmed
    Mutations in the gene that encode cardiac troponin T (cTnT) account for approximately 15% of cases of familial hypertrophic cardiomyopathy (HCM)...
  31. Kamisago M, Sharma S, DePalma S, Solomon S, Sharma P, McDonough B, et al. Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N Engl J Med. 2000;343:1688-96 pubmed
    ..Because distinct mutations in sarcomere proteins cause either dilated or hypertrophic cardiomyopathy, the effects of mutant sarcomere proteins on muscle mechanics must trigger two different series of events that remodel the heart. ..
  32. Girolami F, Ho C, Semsarian C, Baldi M, Will M, Baldini K, et al. Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. J Am Coll Cardiol. 2010;55:1444-53 pubmed publisher
    ..C (MYBPC3), beta-myosin heavy chain (MYH7), regulatory and essential light chains (MYL2, MYL3), troponin-T (TNNT2), troponin-I (TNNI3), alpha-tropomyosin (TPM1), and actin (ACTC). Of the 488 index patients, 4 (0...
  33. Laufer E, Mingels A, Winkens M, Joosen I, Schellings M, Leiner T, et al. The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T. Arterioscler Thromb Vasc Biol. 2010;30:1269-75 pubmed publisher
    ..circulating levels of troponin measured with a recently introduced high sensitive cardiac troponin T (hs-cTnT) assay...
  34. Venkatraman G, Harada K, Gomes A, Kerrick W, Potter J. Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J Biol Chem. 2003;278:41670-6 pubmed
    ..These results suggest that a rightward shift in Ca2+ sensitivity is not the only determinant for the phenotype of DCM. ..
  35. Biener M, Mueller M, Vafaie M, Keller T, Blankenberg S, White H, et al. Comparison of a 3-hour versus a 6-hour sampling-protocol using high-sensitivity cardiac troponin T for rule-out and rule-in of non-STEMI in an unselected emergency department population. Int J Cardiol. 2013;167:1134-40 pubmed publisher
    ..459 patients with either an NSTE-ACS or elevated hs-cTnT not due to MI and hs-cTnT measurements at 0, 3 and 6h were enrolled...
  36. Liu W, Liu W, Hu D, Zhu T, Ma Z, Yang J, et al. Mutation spectrum in a large cohort of unrelated Chinese patients with hypertrophic cardiomyopathy. Am J Cardiol. 2013;112:585-9 pubmed publisher
    ..Direct gene sequencing of ?-myosin heavy chain (MYH7), myosin binding protein-C (MYBPC3), and cardiac troponin T (TNNT2) was performed in 136 unrelated Chinese HC patients. Clinical evaluations were conducted...
  37. Robinson P, Mirza M, Knott A, Abdulrazzak H, Willott R, Marston S, et al. Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy. J Biol Chem. 2002;277:40710-6 pubmed
    ..The functional consequences of this DCM mutation are qualitatively different from the R92Q or any other studied HCM troponin T mutation, suggesting that DCM and HCM may be triggered by distinct primary stimuli. ..
  38. Harada K, Potter J. Familial hypertrophic cardiomyopathy mutations from different functional regions of troponin T result in different effects on the pH and Ca2+ sensitivity of cardiac muscle contraction. J Biol Chem. 2004;279:14488-95 pubmed
    ..These results suggest that different regions of TnT may contribute to the pathogenesis of TnT-linked FHC through different mechanisms. ..
  39. Thierfelder L, Watkins H, MacRae C, Lamas R, McKenna W, Vosberg H, et al. Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell. 1994;77:701-12 pubmed
    ..Further, because the splice site mutation is predicted to function as a null allele, we suggest that abnormal stoichiometry of sarcomeric proteins can cause cardiac hypertrophy. ..
  40. Watt K, Coss E, Pedersen R, Dierkhising R, Heimbach J, Charlton M. Pretransplant serum troponin levels are highly predictive of patient and graft survival following liver transplantation. Liver Transpl. 2010;16:990-8 pubmed publisher
    ..In summary, elevated pretransplant serum TN levels are strongly predictive of mortality and graft loss after liver transplantation and may be helpful in risk stratification of potential liver transplant recipients. ..
  41. Meune C, Zuily S, Wahbi K, Claessens Y, Weber S, Chenevier Gobeaux C. Combination of copeptin and high-sensitivity cardiac troponin T assay in unstable angina and non-ST-segment elevation myocardial infarction: a pilot study. Arch Cardiovasc Dis. 2011;104:4-10 pubmed publisher
    ..We designed a prospective cohort study to compare the performance of high-sensitivity cardiac troponin T (hs-cTnT) measured at admission in combination with copeptin, and the performance of hs-cTnT alone, measured at admission, 3 ..
  42. Fischer D, Remberg F, Bose D, Lichtenberg M, Kümpers P, Lebiedz P, et al. How rapid is rapid? Exemplary results of real-life rapid rule-out troponin timing in troponin-positive acute coronary syndromes without persistent ST-segment elevation in two contrasting German chest pain unit facilities. Eur J Med Res. 2016;21:11 pubmed publisher
  43. Hoeller R, Rubini Gimenez M, Reichlin T, Twerenbold R, Zellweger C, Moehring B, et al. Normal presenting levels of high-sensitivity troponin and myocardial infarction. Heart. 2013;99:1567-72 pubmed publisher
    ..Prospective, multicentre study. We measured hs-cTn using four different methods (hs-cTnT Roche, hs-cTnI Siemens, hs-cTnI Beckman Coulter and hs-cTnI Abbott) in consecutive patients presenting to the ..
  44. Chen B, Rao L, Zhou B, Liu X, Hang P, Wu Y, et al. [Association of TNNT2 gene mutations with idiopathic dilated cardiomyopathy in a Chengdu population]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39:969-72 pubmed
    To determine whether cardiac troponin T gene (TNNT2, AY044273) is the virulence gene of idiopathic dilated cardiomyopathy (IDCM) in a Chengdu population...
  45. Linnemann B, Sutter T, Sixt S, Rastan A, Schwarzwaelder U, Noory E, et al. Elevated cardiac troponin T contributes to prediction of worse in-hospital outcomes after endovascular therapy for acute limb ischemia. J Vasc Surg. 2012;55:721-9 pubmed publisher
    The present study evaluated whether elevated cardiac troponin T (cTnT) was predictive of an increased risk for death or amputation in patients with acute lower limb ischemia (ALI)...
  46. Yamamoto M, Komiyama N, Koizumi T, Nameki M, Yamamoto Y, Toyoda T, et al. Usefulness of rapid quantitative measurement of myoglobin and troponin T in early diagnosis of acute myocardial infarction. Circ J. 2004;68:639-44 pubmed
    ..The rapid quantitative test of T and M is useful for early diagnosis of AMI and as an indicator of its severity, which can be evaluated from the myoglobin concentration in the hyper-acute phase. ..
  47. Bana N, Sanooghi D, Soleimani M, Hayati Roodbari N, Alavi Moghaddam S, Joghataei M, et al. A Comparative Study to Evaluate Myogenic Differentiation Potential of Human Chorion versus Umbilical Cord Blood-derived Mesenchymal Stem Cells. Tissue Cell. 2017;49:495-502 pubmed publisher
    ..Immunocytochemical staining revealed the expression of Desmin, cTnT and α-MHC. Results showed that these cells are potent to differentiate into myoblast- like cells...
  48. Hao P, Fu K, Wang S, Ma C, Xu Z, Cao F, et al. Expression of profilin-1 in endothelial cells of rats with acute myocardial infarction. Eur Rev Med Pharmacol Sci. 2017;21:1318-1322 pubmed
    ..of endothelial microparticles (EMPs) and nitric oxide (NO)], indexes of myocardial injury [cardiac troponin T (cTnT) and creatine kinase-MB (CK-MB)], and mRNA levels of myocardial apoptotic factors (P53, Fas, Bax, and Bcl-2) in ..
  49. Fang X, Poulsen R, Wang Hu J, Shi O, Calvo N, Simmons C, et al. Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytes. FASEB J. 2016;30:3238-55 pubmed publisher
    ..Moreover, decreased methylation levels were found in the promoters of Myh7, Myh7b, Tnni3, and Tnnt2, consistent with the up-regulation of these genes by DNMT3a siRNA...
  50. Eggers K, Jernberg T, Lindahl B. Prognostic Importance of Sex-Specific Cardiac Troponin T 99(th) Percentiles in Suspected Acute Coronary Syndrome. Am J Med. 2016;129:880.e1-880.e12 pubmed publisher
    ..We assessed whether sex-specific cardiac troponin T (cTnT) 99(th) percentiles would improve risk prediction in patients admitted to Swedish coronary care units due to ..
  51. Mochmann H, Scheitz J, Petzold G, Haeusler K, Audebert H, Laufs U, et al. Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study. Circulation. 2016;133:1264-71 pubmed publisher
    ..Further studies are needed to clinically identify the minority of patients with AIS and angiographic evidence of a culprit lesion. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01263964. ..
  52. Chuang A, Hancock D, Horsfall M, Alhammad N, Zhou J, Cullen L, et al. The predictive value of high sensitivity-troponin velocity within the first 6h of presentation for cardiac outcomes regardless of acute coronary syndrome diagnosis. Int J Cardiol. 2016;204:106-11 pubmed publisher
    ..These results may help guide future clinical trials aimed at assessing the utility of cardiac-targeted interventions in this challenging patient population. ..
  53. Aakre K, Kleiven Ã, Skadberg Ã, Bjørkavoll Bergseth M, Melberg T, Strand H, et al. The copeptin response after physical activity is not associated with cardiac biomarkers or asymptomatic coronary artery disease: The North Sea Race Endurance Exercise Study (NEEDED) 2013. Clin Biochem. 2018;52:8-12 pubmed publisher
    ..There was no correlation between changes in copeptin and changes in cardiac biomarkers (hs-cTnI, hs-cTnT and BNP). Copeptin concentrations were normal in the subjects with asymptomatic CAD...
  54. Sharafkhaneh A, Katigbak J, Hirshkowitz M, Sharafkhaneh H, Sharafkhaneh S, Ballantyne C, et al. Severity of hypoxia modulates effect of CPAP on myocardial stress as measured by highly sensitive troponin T. Respir Res. 2015;16:126 pubmed publisher
  55. Perugu S, Rehan V, Chow S, Baylen B. Plasma biomarkers and echocardiographic indices of left ventricular function in very low birth weight infants. J Neonatal Perinatal Med. 2014;7:213-22 pubmed publisher
    ..plasma markers of myocardial function and ischemia [B-type natriuretic peptide] (BNP) and cardiac troponin T (cTnT)] in relationship to echocardiographic indices of left ventricular (LV) function and severity of illness score (..
  56. Cobbaert C, Bootsma M, Boden H, Ahmed T, Hoogslag G, Romijn F, et al. Confounding factors in the relation between high sensitivity cardiac troponin T levels in serum and infarct size of patients with first ST-elevation myocardial infarction. Int J Cardiol. 2014;172:e3-5 pubmed publisher
  57. Garcia Castro M, Reguero J, Moris C, Alonso Montes C, Berrazueta J, Sainz R, et al. Prevalence and spectrum of mutations in the sarcomeric troponin T and I genes in a cohort of Spanish cardiac hypertrophy patients. Int J Cardiol. 2007;121:115-6 pubmed
    We sequenced the coding exons of the cardiac troponins T (TNNT2) and I (TNNI3) genes in 115 Spanish HCM-patients (32% with a family history of the disease). Only two (2%) had mutations in the TNNT2 (Arg278>Cys and Arg92>Lys)...
  58. Sato Y, Kuwabara Y, Taniguchi R, Nishio Y, Miyamoto T, Fujiwara H, et al. Malignant link between chronic heart failure and acute cardiac decompensation in patients with persistently increased serum concentrations of cardiac troponin. Int J Cardiol. 2008;126:171-6 pubmed
    ..Clinical trials that limit myocyte injury during acutely decompensated as well as during chronic compensated HF are warranted. ..
  59. Hoo Z, Candlish J, Teare D. What is an ROC curve?. Emerg Med J. 2017;34:357-359 pubmed publisher
    ..has been developed (Troponin-only Manchester Acute Coronary Syndromes, T-MACS), which include a single biomarker hs-cTnT. In this issue, the authors show how they derive a revised decision aid and describe its performance in a number of ..
  60. Jagodzinski A, Neumann J, Ojeda F, Sörensen N, Wild P, Munzel T, et al. Cardiovascular Biomarkers in Hypertensive Patients with Medical Treatment-Results from the Randomized TEAMSTA Protect I Trial. Clin Chem. 2017;: pubmed publisher
    ..We measured BP, high-sensitivity troponin I (hs-cTnI), high-sensitivity troponin T (hs-cTnT), B-type natriuretic peptide (BNP), and N-terminal-pro-BNP (NT-proBNP) before randomization and after 6 months...
  61. Roberts M, Hare D, MacMillan N, Ratnaike S, Sikaris K, Ierino F. Serial increased cardiac troponin T predicts mortality in asymptomatic patients treated with chronic haemodialysis. Ann Clin Biochem. 2009;46:291-5 pubmed publisher
    ..Serial cardiac troponin T (cTnT) was assayed five times over 12 months in a prospective cohort study of patients with end-stage kidney disease ..
  62. Sumandea M, Pyle W, Kobayashi T, de Tombe P, Solaro R. Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T. J Biol Chem. 2003;278:35135-44 pubmed
    Cardiac Troponin T (cTnT) is one prominent substrate through which protein kinase C (PKC) exerts its effect on cardiomyocyte function...
  63. Soilemezi E, Koco E, Tsimpos C, Tsagourias M, Savvidou S, Matamis D. Effects of continuous positive airway pressure on diaphragmatic kinetics and breathing pattern in healthy individuals. Respirology. 2016;21:1262-9 pubmed publisher
    ..study, we investigate the changes in diaphragmatic kinetics, breathing pattern and work of breathing induced by 10?cmH2 O of continuous positive airway pressure (CPAP)...
  64. Haegeli L, Kotschet E, Byrne J, Adam D, Lockwood E, Leather R, et al. Cardiac injury after percutaneous catheter ablation for atrial fibrillation. Europace. 2008;10:273-5 pubmed publisher
    ..Therefore, troponin T would not be specific for ischaemia in the setting of chest pain post-catheter ablation for AF. ..
  65. Pickering J, Than M, Cullen L, Aldous S, ter Avest E, Body R, et al. Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis. Ann Intern Med. 2017;166:715-724 pubmed publisher
    High-sensitivity assays for cardiac troponin T (hs-cTnT) are sometimes used to rapidly rule out acute myocardial infarction (AMI).
  66. Mauermann E, Bolliger D, Fassl J, Grapow M, Seeberger E, Seeberger M, et al. Postoperative High-Sensitivity Troponin and Its Association With 30-Day and 12-Month, All-Cause Mortality in Patients Undergoing On-Pump Cardiac Surgery. Anesth Analg. 2017;125:1110-1117 pubmed publisher
    ..This analysis suggests that, similar to previous assays, higher postoperative concentrations of hsTnT are independently associated with all-cause mortality in patients undergoing on-pump cardiac surgery. ..
  67. Morita H, Rehm H, Menesses A, McDonough B, Roberts A, Kucherlapati R, et al. Shared genetic causes of cardiac hypertrophy in children and adults. N Engl J Med. 2008;358:1899-908 pubmed publisher
    ..99+/-6.12 years). We sequenced eight genes: MYH7, MYBPC3, TNNT2, TNNI3, TPM1, MYL3, MYL2, and ACTC...