TNNT1

Summary

Gene Symbol: TNNT1
Description: troponin T1, slow skeletal type
Alias: ANM, NEM5, STNT, TNT, TNTS, troponin T, slow skeletal muscle, slow skeletal muscle troponin T, troponin T type 1 (skeletal, slow), troponin-T1, skeletal, slow
Species: human
Products:     TNNT1

Top Publications

  1. Moreno V, Hernandez Romero D, Vilchez J, García Honrubia A, Cambronero F, Casas T, et al. Serum levels of high-sensitivity troponin T: a novel marker for cardiac remodeling in hypertrophic cardiomyopathy. J Card Fail. 2010;16:950-6 pubmed publisher
    ..High-sensitivity troponin T (hs-TnT) could be a reliable indicator of myocardial remodeling, a proposed prognostic marker in HCM...
  2. Sun Y, Wang G, Ji Z, Chao T, Liu Z, Wang X, et al. Three slow skeletal muscle troponin genes in small-tailed Han sheep (Ovis aries): molecular cloning, characterization and expression analysis. Mol Biol Rep. 2016;43:999-1010 pubmed publisher
    ..profile of the three slow skeletal muscle troponin genes TNNC1 (Troponin C type 1), TNNI1 (troponin I type 1) and TNNT1 (troponin T type 1). Three purebred Dorper sheep and another three purebred small-tailed Han sheep were selected...
  3. Wang K, Chen L, Liu L, Cui Y, Zhang X, Jiang J. The effects of atorvastatin on interventional therapy in patients with acute myocardial infarction. Minerva Med. 2019;110:101-106 pubmed publisher
    ..cholesterol [HDL-C] and low-density lipoprotein cholesterol [LDL-C]) and myocardial enzyme indexes (troponin T [TnT] and creatine kinase-MB [CK-MB]) at different time points were detected...
  4. Chen X, Ren S, Dong J, Qiu C, Chen Y, Tao H. Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway. Drug Des Devel Ther. 2019;13:647-655 pubmed publisher
    ..Meanwhile, the levels of creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), troponin T (TnT), TNF-α, IL-6, IL-1β, superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) were ..
  5. Yi M, Yao G, Guo X. [Value of pulse indicator continuous cardiac output monitoring of cardiac function in septic shock patients: a prospective study]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015;27:22-7 pubmed publisher
    ..GEF ), rate of left ventricular pressure increase ( dp/dt max ), echocardiography, and blood troponin T ( TNT ) and B-type natriuretic peptide ( BNP )...
  6. Safdar B, Ong P, Camici P. Identifying Myocardial Ischemia due to Coronary Microvascular Dysfunction in the Emergency Department: Introducing a New Paradigm in Acute Chest Pain Evaluation. Clin Ther. 2018;40:1920-1930 pubmed publisher
    ..Notably, the recently introduced high-sensitivity troponin T (hs-TnT) assay is helping to identify ischemia in patients previously undiagnosed by conventional testing...
  7. Wang Z, Li H, Yao G, Zhu X. [Impacts of sepsis-induced myocardial dysfunction on hemodynamics, organ function and prognosis in patients with septic shock]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015;27:180-4 pubmed publisher
    ..The plasma levels of the biomarkers of myocardial damage, troponin T (TnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured, and the parameters representing organ ..
  8. Arsenault B, Barter P, DeMicco D, Bao W, Preston G, LaRosa J, et al. Prediction of cardiovascular events in statin-treated stable coronary patients of the treating to new targets randomized controlled trial by lipid and non-lipid biomarkers. PLoS ONE. 2014;9:e114519 pubmed publisher
    ..We conducted a substudy of the TNT (Treating to New Targets) study, which was a randomized trial that compared the efficacy of high (80 mg) versus low ..
  9. Cichocka Radwan A, Lelonek M. Annual prognostic factors in chronic heart failure in patients over 80 years old. Kardiol Pol. 2017;75:164-173 pubmed publisher
    ..tests, and selected biomarkers, including N-terminal pro-B-type natriuretic peptide, high-sensitive troponin T (hs-TnT), and high-sensitive C-reactive protein. Participants remained in a prospective follow-up for 12 months...

More Information

Publications151 found, 100 shown here

  1. Kohno T, Kataoka M, Kawakami T, Fukuoka R, Tamura Y, Kimura M, et al. Moderate-to-severe obstructive sleep apnea is associated with subclinical myocardial injury and impaired hemodynamics in pulmonary hypertension patients. Sleep Med. 2017;30:121-127 pubmed publisher
    ..However, high-sensitivity troponin T (hs-TnT) level was significantly higher in moderate-to-severe OSA patients (13 [8-18] vs 6 [4-10] ng/L, p <0.001)...
  2. Ma L, Zhao S. Risk factors for mortality in patients undergoing hemodialysis: A systematic review and meta-analysis. Int J Cardiol. 2017;238:151-158 pubmed publisher
    ..ApoA3, high-density lipoprotein (HDL), total cholesterol, hemoglobin A1c (HbA1c), serum phosphate, troponin T (TnT), and B-type natriuretic peptide (BNP). Relative risks with 95% confidence intervals were derived...
  3. Katti P, Thimmaya D, Madan A, Nongthomba U. Overexpression of miRNA-9 Generates Muscle Hypercontraction Through Translational Repression of Troponin-T in Drosophila melanogaster Indirect Flight Muscles. G3 (Bethesda). 2017;7:3521-3531 pubmed publisher
    ..Troponin-T (TnT) was identified as major structural gene target of miR-9a...
  4. Cheng L, Xing H, Mao X, Li L, Li X, Li Q. Lipocalin-2 promotes m1 macrophages polarization in a mouse cardiac ischaemia-reperfusion injury model. Scand J Immunol. 2015;81:31-8 pubmed publisher
    ..We found that Lcn2 neutralization decreased the recruitment of neutrophils and macrophages. Troponin T (TnT) production, 24 h after myocardial IR injury, was reduced through anti-Lcn2 antibody administration...
  5. Cai J, Wang L. [Looking back 2018--focused on colorectal cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2019;22:9-16 pubmed
    ..Although several studies have confirmed that total neoadjuvant therapy (TNT) can improve pathological complete response (pCR) rate and DFS of patients with colorectal cancer, we do not ..
  6. Johnson D, Angus C, Chalovich J. Stepwise C-Terminal Truncation of Cardiac Troponin T Alters Function at Low and Saturating Ca2. Biophys J. 2018;115:702-712 pubmed publisher
    ..It now appears that the C-terminal 14 amino acids of cardiac troponin T (TnT) control the level of activity at both low and high Ca2+...
  7. Shao A, Qi X, Li Q, Jia W, Wei L, Hou W, et al. [Dynamic changes of complement level in patients with acute coronary syndrome and its relationships with myocardial injury]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:515-519 pubmed publisher
    ..2) The levels of troponin T (TnT), creatine kinase-MB (CK-MB), solution intercellular adhesion molecule-1 (sICAM-1), global registry of acute ..
  8. Okuda S, Sufu Shimizu Y, Kato T, Fukuda M, Nishimura S, Oda T, et al. CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy. Biochem Biophys Res Commun. 2018;496:1250-1256 pubmed publisher
    Cardiac Troponin T (TnT) mutation-linked familial hypertrophic cardiomyopathy (FHC) is known to cause sudden cardiac death at a young age...
  9. Alonso N, Lupón J, Barallat J, de Antonio M, Domingo M, Zamora E, et al. Impact of diabetes on the predictive value of heart failure biomarkers. Cardiovasc Diabetol. 2016;15:151 pubmed
    ..serum concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), ST2, galectin-3, high-sensitivity C reactive protein (hs-CRP), cystatin-C, soluble transferrin receptor (sTfR), ..
  10. Toyota N, Fujitsuka C, Ishibashi G, S Yoshida L, Takano Ohmuro H. Morphological Modifications in Myofibrils by Suppressing Tropomyosin 4? in Chicken Cardiac Myocytes. Cell Struct Funct. 2016;41:45-54 pubmed publisher
    Tropomyosin (TPM) localizes along F-actin and, together with troponin T (TnT) and other components, controls calcium-sensitive muscle contraction...
  11. Batlle M, Campos B, Farrero M, Cardona M, Gonzalez B, Castel M, et al. Use of serum levels of high sensitivity troponin T, galectin-3 and C-terminal propeptide of type I procollagen at long term follow-up in heart failure patients with reduced ejection fraction: Comparison with soluble AXL and BNP. Int J Cardiol. 2016;225:113-119 pubmed publisher
    ..Here we evaluate 3 biomarkers, high sensitivity troponin T (hs-TnT), galectin-3 (Gal-3) and C-terminal propeptide of type I procollagen (CICP), compare them with a recently described ..
  12. Schilder R, Raynor M. Molecular plasticity and functional enhancements of leg muscles in response to hypergravity in the fruit fly Drosophila melanogaster. J Exp Biol. 2017;220:3508-3518 pubmed publisher
    ..splicing of the sarcomere gene troponin T (Dmel\up; Fbgn0004169, herein referred to by its synonym TnT), a process that was previously demonstrated to precisely correlate with quantitative variation in body weight ..
  13. Gu H, Xie M, Xu L, Zheng X, Yang Y, Lv X. The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury. Transpl Int. 2015;28:1436-44 pubmed publisher
    ..Furthermore, the decreased infiltration of mononuclear cells and production of troponin T (TnT) induced by IL-18BP treatment were both abrogated by additional administration of recombinant mouse IL-17 (rmIL-17)...
  14. Kimura M, Kohno T, Kawakami T, Kataoka M, Tsugu T, Akita K, et al. Midterm Effect of Balloon Pulmonary Angioplasty on Hemodynamics and Subclinical Myocardial Damage in Chronic Thromboembolic Pulmonary Hypertension. Can J Cardiol. 2017;33:463-470 pubmed publisher
    ..output (CO) and subclinical myocardial damage, we examined hemodynamics and serum high-sensitivity troponin T (hs-TnT) levels before, 1 week after, and 6 months after BPA...
  15. Messer A, Bayliss C, El Mezgueldi M, Redwood C, Ward D, Leung M, et al. Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation. Arch Biochem Biophys. 2016;601:113-20 pubmed publisher
    We investigated the effect of 7 Hypertrophic Cardiomyopathy (HCM)-causing mutations in troponin T (TnT) on troponin function in thin filaments reconstituted with actin and human cardiac tropomyosin...
  16. Sinclair K, Yerkovich S, Hopkins P, Chambers D. Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung. Stem Cell Res Ther. 2016;7:91 pubmed publisher
    ..Molecular inhibitors were used to determine the contribution of microtubules/tunnelling nanotubes (TNTs, cytochalasin D), gap junctions (carbenoxolone), connexin-43 (gap26) and microvesicles (dynasore)...
  17. Jiang D, Gao F, Zhang Y, Wong D, Li Q, Tse H, et al. Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage. Cell Death Dis. 2016;7:e2467 pubmed publisher
    ..The efficient mitochondrial transfer was associated with increased formation of tunneling nanotubes (TNTs) between MSCs and CECs, tubular connections that allowed direct intercellular communication...
  18. Boekhout A, Gietema J, Milojkovic Kerklaan B, van Werkhoven E, Altena R, Honkoop A, et al. Angiotensin II-Receptor Inhibition With Candesartan to Prevent Trastuzumab-Related Cardiotoxic Effects in Patients With Early Breast Cancer: A Randomized Clinical Trial. JAMA Oncol. 2016;2:1030-7 pubmed publisher
    ..whether the N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-TnT) can be used as surrogate markers and whether genetic variability in germline ERBB2 (formerly HER2 or HER2/neu) ..
  19. Vyatchin I, Shevchenko U, Lazarev S, Matusovsky O, Shelud ko N. Troponin-like regulation in muscle thin filaments of the mussel Crenomytilus grayanus (Bivalvia: Mytiloida). Biochim Biophys Acta. 2015;1854:1444-50 pubmed publisher
    ..proteins appeared to correspond to the troponin components from the skeletal muscles of vertebrates (TnC, TnI and TnT). The reconstituted mussel troponin complex confers to actomyosin-tropomyosin more than 80% Ca2+-sensitivity...
  20. Al Rifai M, DeFilippis A, McEvoy J, Hall M, Acien A, Jones M, et al. The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2017;258:119-130 pubmed publisher
    ..necrosis factor alpha (TNF-?)], thrombosis (fibrinogen, D-dimer, homocysteine), myocardial injury (troponin T; TnT), endothelial damage (albumin: creatinine ratio), and vascular function [aortic & carotid distensibility, flow-..
  21. Sun J, Axelsson J, Machowska A, Heimburger O, Barany P, Lindholm B, et al. Biomarkers of Cardiovascular Disease and Mortality Risk in Patients with Advanced CKD. Clin J Am Soc Nephrol. 2016;11:1163-72 pubmed publisher
    ..levels of albumin, ferritin, high-sensitivity C-reactive protein (hsCRP), IGF-1, IL-6, orosomucoid, troponin T (TnT), TNF, soluble intracellular adhesion molecule, soluble vascular cellular adhesion molecule 1 (sVCAM-1), and ..
  22. Nakanishi K, Fukuda S, Yamashita H, Hasegawa T, Kosaka M, Shirai N, et al. High-sensitive cardiac troponin T as a novel predictor for recurrence of atrial fibrillation after radiofrequency catheter ablation. Europace. 2017;: pubmed publisher
    We aimed to determine whether elevated serum high-sensitive cardiac troponin T (hs-TnT) levels predict atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI)...
  23. Gordon A, Homsher E, Regnier M. Regulation of contraction in striated muscle. Physiol Rev. 2000;80:853-924 pubmed
    ..Adjacent Tm are coupled in their overlap regions where Tm movement is also controlled by interactions with TnT. TnT also interacts with TnC-TnI in a Ca(2+)-dependent manner...
  24. Sahoo P, Jena S, Samanta L. Tunneling nanotubes: A versatile target for cancer therapy. Curr Cancer Drug Targets. 2017;: pubmed publisher
    ..According to the results of this study, it can be concluded that an effective targeting of AML and ALL cells can be performed by anti-CD45Ra and anti-CD123 monoclonal antibodies through their effector functions and apoptosis induction...
  25. Roca G, Redline S, Claggett B, Bello N, Ballantyne C, Solomon S, et al. Sex-Specific Association of Sleep Apnea Severity With Subclinical Myocardial Injury, Ventricular Hypertrophy, and Heart Failure Risk in a Community-Dwelling Cohort: The Atherosclerosis Risk in Communities-Sleep Heart Health Study. Circulation. 2015;132:1329-37 pubmed publisher
    ..We hypothesize that the relationship between OSA and high-sensitivity troponin T (hs-TnT), cardiac structure, and CV outcomes differs by sex...
  26. Marlinge M, Deharo P, Joulia F, Coulange M, Vairo D, Gaudry M, et al. Troponins in scuba divers with immersion pulmonary edema. Biosci Rep. 2018;38: pubmed publisher
    ..of cardiac markers (creatine phosphokinase (CPK), brain natriuretic peptide (BNP), highly sensitive troponin T (TnT-hs) and ultrasensitive troponin I (TnI-us) of divers with IPE...
  27. Pareek M, Bhatt D, Vaduganathan M, Biering Sørensen T, Qamar A, Diederichsen A, et al. Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event. Eur J Prev Cardiol. 2017;24:1648-1659 pubmed publisher
    ..including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), ..
  28. Michael J, Gollapudi S, Chandra M. Interplay between the effects of a Protein Kinase C phosphomimic (T204E) and a dilated cardiomyopathy mutation (K211Δ or R206W) in rat cardiac troponin T blunts the magnitude of muscle length-mediated crossbridge recruitment against the β-myosin heav. J Muscle Res Cell Motil. 2016;37:83-93 pubmed publisher
    ..Recently, we demonstrated that the functional effects of T204E, a PKC phosphomimic of cardiac troponin T (TnT), were differently modulated by α- and β-myosin heavy chain (MHC) isoforms...
  29. Panasiuk M, Rychłowski M, Derewońko N, Bienkowska Szewczyk K. Tunneling Nanotubes as a Novel Route of Cell-to-Cell Spread of Herpesviruses. J Virol. 2018;92: pubmed publisher
    ..type of cellular connection, consisting of long, thin, actin-rich membrane extensions named tunneling nanotubes (TNTs), has been shown to play an important role in cell-to-cell spread of HIV and influenza virus...
  30. Miyata Y, Kumagai K, Nagaoka T, Kitaura K, Kaneda G, Kanazawa H, et al. Clinicopathological significance and prognostic value of Wilms' tumor gene expression in colorectal cancer. Cancer Biomark. 2015;15:789-97 pubmed publisher
    ..analyzed TAA expression levels and investigated their relationship with clinical factors in adjacent normal mucosa (ANM) and CRC tissue...
  31. Li X, Zhang J, Zhu Y, Su J. Domain Motions and Functionally-Key Residues of L-Alanine Dehydrogenase Revealed by an Elastic Network Model. Int J Mol Sci. 2015;16:29383-97 pubmed publisher
    ..of L-MtAlaDH were investigated by using the Gaussian network model (GNM) and the anisotropy network model (ANM)...
  32. Lotufo G, Belden J, Fisher J, Chen S, Mowery R, Chambliss C, et al. Accumulation and depuration of trinitrotoluene and related extractable and nonextractable (bound) residues in marine fish and mussels. Environ Pollut. 2016;210:129-36 pubmed publisher
    To determine if trinitrotoluene (TNT) forms nonextractable residues in mussels (Mytilus galloprovincialis) and fish (Cyprinodon variegatus) and to measure the relative degree of accumulation as compared to extractable TNT and its major ..
  33. Nagendran S, Vishnoi P, Murugavel R. Triphenylbenzene Sensor for Selective Detection of Picric Acid. J Fluoresc. 2017;27:1299-1305 pubmed publisher
    ..25 ppm at a signal to noise ratio of 3. Other related analytes (i.e. TNT, DNT and DNB) show very little effect on the fluorescence intensity of [NHMe]3TAPB...
  34. Okafo G, Prevedel L, Eugenin E. Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread. Sci Rep. 2017;7:16660 pubmed publisher
    ..by soluble factors, exosomes, gap junction (GJ) channels, and the recently described tunneling nanotubes (TNTs)...
  35. Høiseth A, Brynildsen J, Hagve T, Christensen G, Søyseth V, Omland T, et al. The influence of heart failure co-morbidity on high-sensitivity troponin T levels in COPD exacerbation in a prospective cohort study: data from the Akershus cardiac examination (ACE) 2 study. Biomarkers. 2016;21:173-9 pubmed publisher
    Troponin (hs-TnT) levels predict mortality after acute exacerbation of COPD (AECOPD). Whether this is independent of heart failure (HF) is not established...
  36. Kim S, Nyande B, Kim H, Park J, Lee W, Oh M. Numerical analysis of thermal decomposition for RDX, TNT, and Composition B. J Hazard Mater. 2016;308:120-30 pubmed publisher
    ..b>TNT, RDX and Composition B have been used as military explosives, and they are very sensitive to thermal shock...
  37. Karimi A, Razaghi R, Navidbakhsh M, Sera T, Kudo S. Computing the stresses and deformations of the human eye components due to a high explosive detonation using fluid-structure interaction model. Injury. 2016;47:1042-50 pubmed publisher
    ..body, lens, vitreous, retina, sclera, optic nerve, and muscles, attributed to PBW induced by trinitrotoluene (TNT) explosion via a Lagrangian-Eulerian computational coupling model...
  38. Her A, Cho K, Singh G, Garg S, Kim Y, Koo B, et al. A Comparison of Peri-Procedural Myocardial Infarction between Paclitaxel-Coated Balloon and Drug-Eluting Stent on De Novo Coronary Lesions. Yonsei Med J. 2017;58:99-104 pubmed publisher
    ..5 x the 99th percentile upper reference limit of normal for creatine kinase-myocardial band (CK-MB) or troponin T (TnT). One hundred four patients (52 receiving PCB and 52 receiving DES) were enrolled in this study...
  39. Chen C, Ling L, Li F. Double-Sided Transparent TiO2 Nanotube/ITO Electrodes for Efficient CdS/CuInS2 Quantum Dot-Sensitized Solar Cells. Nanoscale Res Lett. 2017;12:4 pubmed publisher
    ..PCEs) of quantum dot-sensitized solar cells (QDSSCs) based on CdS-sensitized TiO2 nanotube (TNT) electrodes, two methods are employed on the basis of our previous work...
  40. Cotič J, Ferran M, Karišik J, Jerin A, Pussinen P, Nemec A, et al. Oral health and systemic inflammatory, cardiac and nitroxid biomarkers in hemodialysis patients. Med Oral Patol Oral Cir Bucal. 2017;22:e432-e439 pubmed
    ..patients were periodontally examined and their sera were assayed for C reactive protein (CRP), cardiac troponin T (TnT), nitrite/nitrate (NOx) and antibody levels to A. actinomycetemcomitans and P. gingivalis...
  41. Anirudhan T, Nair S, Sasidharan A. Methacrylate Stitched ?-Cyclodextrin Embedded with Nanogold/Nanotitania- A Skin Adhesive Device for Enhanced Transdermal Drug Delivery. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..The ability of gold nanoparticle (AuNP) and hydrophobic titanium nanotube (TNT) to enhance the skin permeability was explored...
  42. Hort J, Ford R, Eldeghaidy S, Francis S. Thermal taster status: Evidence of cross-modal integration. Hum Brain Mapp. 2016;37:2263-75 pubmed publisher
    ..Behaviourally, the TT group perceived gustatory and trigeminal stimuli significantly more intense than TnTs, and were significantly more discriminating of CO2 level...
  43. Via S, Zinnert J, Young D. Multiple metrics quantify and differentiate responses of vegetation to composition B. Int J Phytoremediation. 2017;19:56-64 pubmed
    ..Composition B, which comprises 60% hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and 40% 2,4,6-trinitrotoluene (TNT), and grown for 2 months...
  44. Abdullah M, Kamarudin S, Shyuan L. TiO2 Nanotube-Carbon (TNT-C) as Support for Pt-based Catalyst for High Methanol Oxidation Reaction in Direct Methanol Fuel Cell. Nanoscale Res Lett. 2016;11:553 pubmed publisher
    In this study, TiO2 nanotubes (TNTs) were synthesized via a hydrothermal method using highly concentrated NaOH solutions varying from 6 to 12 M at 180 °C for 48 h...
  45. Pirlet C, Pierard L, Legrand V, Gach O. Ratio of high-sensitivity troponin to creatine kinase-MB in takotsubo syndrome. Int J Cardiol. 2017;243:300-305 pubmed publisher
    ..We sought to determine whether the ratio of high-sensitivity cardiac troponin T (hs-TnT) to the myocardial fraction of creatine kinase (CKMB) could be a potent discriminator between TT and MI patients...
  46. Oliveira W, Arruda I, Silva G, Machado G, Coelho L, Correia M. Functionalization of titanium dioxide nanotubes with biomolecules for biomedical applications. Mater Sci Eng C Mater Biol Appl. 2017;81:597-606 pubmed publisher
    ..The production of a nanostructured surface can be achieved by means of titanium dioxide nanotubes (TNTs) which can have dimensions equivalent to the nanometric components of human bone, in addition to increasing the ..
  47. Xia K. Multiscale virtual particle based elastic network model (MVP-ENM) for normal mode analysis of large-sized biomolecules. Phys Chem Chem Phys. 2017;20:658-669 pubmed publisher
    ..based Gaussian network model (MVP-GNM) and the multiscale virtual particle based anisotropic network model (MVP-ANM), are proposed...
  48. Ong K, Waters D, Fayyad R, Vogt L, Melamed S, DeMicco D, et al. Relationship of High-Density Lipoprotein Cholesterol With Renal Function in Patients Treated With Atorvastatin. J Am Heart Assoc. 2018;7: pubmed publisher
    ..investigated whether HDL cholesterol levels predicted renal function in atorvastatin-treated patients in the TNT (Treating to New Targets) trial. A total of 9542 participants were included in this analysis...
  49. Chandra V, Gollapudi S, Chandra M. Rat cardiac troponin T mutation (F72L)-mediated impact on thin filament cooperativity is divergently modulated by α- and β-myosin heavy chain isoforms. Am J Physiol Heart Circ Physiol. 2015;309:H1260-70 pubmed publisher
    ..causal link between disparate effects of human hypertrophic cardiomyopathy (HCM)-related mutations in troponin T (TnT) and α- and β-myosin heavy chain (MHC) isoforms on cardiac contractile phenotype remains poorly understood...
  50. Zhou J, Stein P, Leu N, Chmatal L, Xue J, Ma J, et al. Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. Hum Mol Genet. 2015;24:6505-14 pubmed publisher
    ..Alleles of the human SYCP2L locus are associated with age at natural menopause (ANM). SYCP2L is a paralogue of the synaptonemal complex protein SYCP2 and is expressed exclusively in oocytes...
  51. Choodum A, Malathong K, NicDaeid N, Limsakul W, Wongniramaikul W. A cost effective hydrogel test kit for pre and post blast trinitrotoluene. Forensic Sci Int. 2016;266:202-208 pubmed publisher
    ..effective hydrogel test kit was successfully developed for the detection of pre- and post-blast trinitrotoluene (TNT). A polyvinyl alcohol (PVA) hydrogel matrix was used to entrap the potassium hydroxide (KOH) colourimetric reagent...
  52. Naumenko E, Ahlemeyer B, Baumgart Vogt E. Species-specific differences in peroxisome proliferation, catalase, and SOD2 upregulation as well as toxicity in human, mouse, and rat hepatoma cells induced by the explosive and environmental pollutant 2,4,6-trinitrotoluene. Environ Toxicol. 2017;32:989-1006 pubmed publisher
    2,4,6-Trinitrotoluene (TNT) has been widely used as an explosive substance and its toxicity is still of interest as it persisted in polluted areas. TNT is metabolized in hepatocytes which are prone to its toxicity...
  53. Liang S, Hsu D, Lin C, Kao C, Huang D, Chien C, et al. Enhancement of microbial 2,4,6-trinitrotoluene transformation with increased toxicity by exogenous nutrient amendment. Ecotoxicol Environ Saf. 2017;138:39-46 pubmed publisher
    In this study, the bacterial strain Citrobacter youngae strain E4 was isolated from 2,4,6-trinitrotoluene (TNT)-contaminated soil and used to assess the capacity of TNT transformation with/without exogenous nutrient amendments. C...
  54. Saad Y, Idris H, Shugman I, Kadappu K, Rajaratnam R, Thomas L, et al. Evaluation of Serial High Sensitivity Troponin T Levels in Individuals Without Overt Coronary Heart Disease Following Exercise Stress Testing. Heart Lung Circ. 2017;26:660-666 pubmed publisher
    ..Extreme physical activity may lead to marked elevations in creatine kinase MB and TnT levels...
  55. Parkkonen O, Nieminen M, Vesterinen P, Tervahartiala T, Perola M, Salomaa V, et al. Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome. PLoS ONE. 2017;12:e0173371 pubmed publisher
    ..679 (p<0.0001) surpassing troponin T (TnT) at 0.522 (p = 0.66)...
  56. Li C, Tseng C, Lai S, Yang C, Hung W. Photocatalytic Activities Enhanced by Au-Plasmonic Nanoparticles on TiO2 Nanotube Photoelectrode Coated with MoO3. Nanoscale Res Lett. 2017;12:560 pubmed publisher
    ..3D hierarchical structure consists of a TiO2 nanotube core and a MoO3 shell (referred to as TNTs@MoO3), as characterized by field emission scanning electron microscopy and X-ray photoelectron ..
  57. Ariyarathna T, Vlahos P, Tobias C, Smith R. Sorption kinetics of TNT and RDX in anaerobic freshwater and marine sediments: Batch studies. Environ Toxicol Chem. 2016;35:47-55 pubmed publisher
    ..The present study measured the kinetics of 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) sorption onto 2 marine sediments of varying grain sizes (silt vs ..
  58. Qi Y, Qi Z, Li Z, Wong C, So C, Lo I, et al. Role of TRPV1 in the Differentiation of Mouse Embryonic Stem Cells into Cardiomyocytes. PLoS ONE. 2015;10:e0133211 pubmed publisher
    ..and TRPV1-shRNA also suppressed the expression of cardiomyocyte marker genes, including cardiac actin, c-TnT, c-TnI, and α-MHC...
  59. Streb M, Mecklinger A, Anderson M, Johanna L, Michael T. Memory control ability modulates intrusive memories after analogue trauma. J Affect Disord. 2016;192:134-42 pubmed publisher
    ..Retrieval suppression was examined with the think/no-think task (TNT) using behavioral and event related potential (ERP) measures...
  60. Liang Y, Kuo D, Allen H, Di Toro D. Experimental determination of solvent-water partition coefficients and Abraham parameters for munition constituents. Chemosphere. 2016;161:429-437 pubmed publisher
    ..TNX), hexahydro-1,3-dinitroso-5- nitro-1,3,5-triazine (DNX), 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitrobenzene (TNB), and 4-nitroanisole...
  61. Spampinato R, Tasca M, Borger M, Schloma V, Dmitrieva Y, Mende M, et al. Advanced symptoms are associated with myocardial damage in patients with severe aortic stenosis. J Cardiol. 2017;70:41-47 pubmed publisher
    ..peak systolic strain (GLPS), NT-pro-B-type natriuretic peptide (BNP), and high-sensitive troponin T (hs-TNT) were determined at the time of admission. AS severity was similar between groups...
  62. Wang H, Wang P, Chen X, Wu Z. Uniformly active phase loaded selective catalytic reduction catalysts (V2O5/TNTs) with superior alkaline resistance performance. J Hazard Mater. 2017;324:507-515 pubmed publisher
    ..V2O5/TNTs catalyst was a promising substitute for the commercial vanadium catalysts and the work conducted herein provided a ..
  63. Lee B, Choi M, Kim D, Oh K. Genome Shuffling of Stenotrophomonas maltophilia OK-5 for Improving the Degradation of Explosive RDX (Hexahydro-1,3,5-trinitro-1,3,5-triazine). Curr Microbiol. 2017;74:268-276 pubmed publisher
    ..In addition, the mRNA levels of pnrB encoding a TNT nitroreductase, and algA involved in exopolymer biosynthesis, were slightly higher in the shuffled strain, but not ..
  64. Yu H, Becker T, Nic Daéid N, Lewis S. Fundamental studies of the adhesion of explosives to textile and non-textile surfaces. Forensic Sci Int. 2017;273:88-95 pubmed publisher
    ..Crystals of TNT, PETN and RDX were mounted onto tipless AFM cantilevers and repeatedly brought into contact with a range of ..
  65. Huo X, Liu P, Zhu J, Liu X, Ju H. Electrochemical immunosensor constructed using TiO2 nanotubes as immobilization scaffold and tracing tag. Biosens Bioelectron. 2016;85:698-706 pubmed publisher
    ..The polyaniline (PANI) was coated on TNTs by chemical oxidative polymerization, and gold nanoparticles were deposited on TNT-PANI with a routine chemical ..
  66. Zhang Y, Yu Z, Jiang D, Liang X, Liao S, Zhang Z, et al. iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-? Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy. Stem Cell Reports. 2016;7:749-763 pubmed publisher
    ..expression, iPSC-MSCs are more responsive to tumor necrosis factor alpha (TNF-?)-induced tunneling nanotube (TNT) formation for mitochondrial transfer to CMs, which is regulated via the TNF-?/NF-?B/TNF?IP2 signaling pathway...
  67. Zhu S, Abounit S, Korth C, Zurzolo C. Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine. Open Biol. 2017;7: pubmed publisher
    ..thus indicating an efficient transfer in vitro DISC1 aggregates were found inside tunnelling nanotubes (TNTs) and transfer was enhanced by increasing TNT formation and notably by dopamine treatment, which also induces DISC1 ..
  68. Kowalik E, Klisiewicz A, Rybicka J, Biernacka E, Hoffman P. High sensitivity cardiac troponin T and systemic right ventricular function in adults with congenitally corrected transposition of the great arteries. Int J Cardiol. 2017;241:168-172 pubmed publisher
    ..A cross-sectional study of adults with ccTGA was conducted. Patients underwent transthoracic echocardiography, hs-TnT and NTproBNP measurements...
  69. Huang J, Zhang X, Yan W, Chen Z, Shuai X, Wang A, et al. Nanotubular topography enhances the bioactivity of titanium implants. Nanomedicine. 2017;13:1913-1923 pubmed publisher
    ..In this study, nano-scale TiO2 nanotube topography (TNT), micro-scale sand blasted-acid etched topography (SLA), and hybrid sand blasted-acid etched/nanotube topography (..
  70. Bariana M, Dwivedi P, Ranjitkar S, Kaidonis J, Losic D, Anderson P. Glypican-based drug releasing titania implants to regulate BMP2 bioactivity as a potential approach for craniosynostosis therapy. Nanomedicine. 2018;14:2365-2374 pubmed publisher
    ..Electrochemically anodized Titania nanotube (TNT) arrays have been recognized as a promising localized, long-term drug delivery platform for bone-related therapies...
  71. Hoang D, Vinh L, Flouri T, Stamatakis A, von Haeseler A, Minh B. MPBoot: fast phylogenetic maximum parsimony tree inference and bootstrap approximation. BMC Evol Biol. 2018;18:11 pubmed publisher
    ..6 (DNA) to 4.1 times (protein data) slower than the standard bootstrap with a fast search routine in TNT (fast-TNT). However, for non-uniform cost matrices MPBoot is 5 (DNA) to 13 times (protein data) (range:0.3-63...
  72. Shinkai Y, Nishihara Y, Amamiya M, Wakayama T, Li S, Kikuchi T, et al. NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals. Free Radic Biol Med. 2016;91:178-87 pubmed publisher
    While the biodegradation of 2,4,6-trinitrotoluene (TNT) via the release of nitrite is well established, mechanistic details of the reaction in mammals are unknown...
  73. Mahmoud K, Abdel Wahab A, Zourob M. Selective electrochemical detection of 2,4,6-trinitrotoluene (TNT) in water based on poly(styrene-co-acrylic acid) PSA/SiO2/Fe3O4/AuNPs/lignin-modified glassy carbon electrode. Water Sci Technol. 2015;72:1780-8 pubmed publisher
    ..L-MMS) modified glassy carbon electrode (GCE) was developed for the selective detection of trace trinitrotoluene (TNT) from aqueous media with high sensitivity...
  74. Giraldo Giraldo N, Vásquez Velásquez J, Roldán Cano P, Ospina Astudillo C, Sosa Cardona Y. COST-EFFECTIVENESS OF EARLY NUTRITIONAL THERAPY IN MALNOURISHED ADULT PATIENTS IN A HIGH COMPLEXITY HOSPITAL. Nutr Hosp. 2015;32:2938-47 pubmed publisher
    ..Terapia Nutricional Precoz (TNP), mientras que la cohorte retrospectiva recibió Terapia Nutricional Tardía (TNT)...
  75. Osteikoetxea Molnár A, Szabó Meleg E, Toth E, Oszvald Á, Izsépi E, Kremlitzka M, et al. The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes. Cell Mol Life Sci. 2016;73:4531-4545 pubmed
    Tunneling nanotubes (TNTs) are long intercellular connecting structures providing a special transport route between two neighboring cells...
  76. Ahmadi S, Riahi Z, Eslami A, Sadrnezhaad S. Fabrication mechanism of nanostructured HA/TNTs biomedical coatings: an improvement in nanomechanical and in vitro biological responses. J Mater Sci Mater Med. 2016;27:150 pubmed publisher
    ..The calculated friction coefficient enhanced from 0.65 ± 0.04 for sole hydroxyapatite layer to the 0.46 ± 0.02 for hydroxyapatite/TiO2 nanotubes due to presence of nanotubular TiO2 intermediate layer. ..
  77. Matula Z, Nemeth A, Lorincz P, Szepesi A, Brozik A, Buzás E, et al. The Role of Extracellular Vesicle and Tunneling Nanotube-Mediated Intercellular Cross-Talk Between Mesenchymal Stem Cells and Human Peripheral T Cells. Stem Cells Dev. 2016;25:1818-1832 pubmed
    ..of cytoplasmic components between human AD-MSCs and primary T lymphocytes, mediated by tunneling nanotubes (TNTs) derived exclusively from the T cells. In contrast, TNTs couldn't be observed between AD-MSCs and the Jurkat cells...
  78. Rier H, Jager A, Sleijfer S, van Rosmalen J, Kock M, Levin M. Low muscle attenuation is a prognostic factor for survival in metastatic breast cancer patients treated with first line palliative chemotherapy. Breast. 2017;31:9-15 pubmed publisher
    ..study determined the association of skeletal muscle measures with overall survival (OS) and time to next treatment (TNT)...
  79. Roushani M, Shahdost Fard F, Azadbakht A. Using Au@nano-C60 nanocomposite as an enhanced sensing platform in modeling a TNT aptasensor. Anal Biochem. 2017;534:78-85 pubmed publisher
    ..facile nanocomposite (Au@nano-C60) to fabricate an aptasensor for the ultra-sensitive and selective detection of TNT. The gold nanoparticles decorated fullerene onto a glassy carbon electrode was prepared using an electrochemical ..
  80. Lu H, Quan S, Xu S. Highly Sensitive Ratiometric Fluorescent Sensor for Trinitrotoluene Based on the Inner Filter Effect between Gold Nanoparticles and Fluorescent Nanoparticles. J Agric Food Chem. 2017;65:9807-9814 pubmed publisher
    In this work, we developed a simple and sensitive ratiometric fluorescent assay for sensing trinitrotoluene (TNT) based on the inner filter effect (IFE) between gold nanoparticles (AuNPs) and ratiometric fluorescent nanoparticles (RFNs), ..
  81. Harada Y, Koskinas K, Ndrepepa G, Räber L, Braun S, Zanchin T, et al. Postprocedural high-sensitivity troponin T and prognosis in patients with non-ST-segment elevation myocardial infarction treated with early percutaneous coronary intervention. Cardiovasc Revasc Med. 2018;19:480-486 pubmed publisher
    The association of postprocedural high-sensitivity troponin T (hs-TnT) with prognosis of non-ST-segment elevation myocardial infarction (NSTEMI) patients is incompletely investigated...
  82. Larsson L, Wang X, Yu F, Höök P, Borg K, Chong S, et al. Adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease. Am J Physiol Cell Physiol. 2008;295:C722-31 pubmed publisher
    Slow troponin T (TnT) plays an indispensable role in skeletal muscle function. Alternative RNA splicing in the NH(2)-terminal region produces high-molecular-weight (HMW) and low-molecular-weight (LMW) isoforms of slow TnT...
  83. Haider D, Klemenz T, Fiedler G, Nakas C, Exadaktylos A, Leichtle A. High sensitive cardiac troponin T: Testing the test. Int J Cardiol. 2017;228:779-783 pubmed publisher
    High sensitive cardiac troponin T (hs-TnT) found its way into everyday clinical routine to diagnose acute myocardial infarction (AMI). However, its levels vary considerably based on the underlying pathophysiology of the patients...
  84. Won J, Borden R. Laboratory Column Evaluation of High Explosives Attenuation in Grenade Range Soils. J Environ Qual. 2017;46:968-974 pubmed publisher
    ..Experimental results showed extensive 2,4,6-trinitrotoluene (TNT) degradation with minimal leaching, consistent with prior batch microcosm results...
  85. Li M, Gao L, Chen J, Zhang Y, Wang J, Lu X, et al. Controllable Release of Interleukin-4 in Double-Layer Sol-Gel Coatings on TiO2 Nanotubes for Modulating Macrophage Polarization. Biomed Mater. 2017;: pubmed publisher
    ..To investigate this possibility, drug-loaded double-layer sol-gel coatings were fabricated on TiO2 nanotubes (TNTs), which were used to modulate the switch from the M1 to the M2 phenotype by controlled release of interleukin (IL)-..
  86. Jin J, Chen A, Ogut O, Huang Q. Conformational modulation of slow skeletal muscle troponin T by an NH(2)-terminal metal-binding extension. Am J Physiol Cell Physiol. 2000;279:C1067-77 pubmed
    Troponin T (TnT) is an essential element in the thin filament Ca(2+)-regulatory system controlling striated muscle contraction...
  87. Wu L, Tang C, Liu M. Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Am J Physiol Regul Integr Comp Physiol. 2001;281:R408-16 pubmed
    ..Phosphorylation of TnT was unaffected during the progression of sepsis...
  88. Gil V, Lecina D, Grebner C, Guallar V. Enhancing backbone sampling in Monte Carlo simulations using internal coordinates normal mode analysis. Bioorg Med Chem. 2016;24:4855-4866 pubmed publisher
    ..evaluated the new approach using two test systems, ubiquitin and c-Src kinase, and the differences to the original ANM method are assessed by comparing both results to reference molecular dynamics simulations...
  89. Rivera Gasperín S, Morón Rios M. Phylogenetic Relationships within Phyllophaga Harris (sensu lato) (Coleoptera: Melolonthidae, Melolonthinae) with Emphasis on Listrochelus Blanchard. Neotrop Entomol. 2017;46:524-536 pubmed publisher
    ..A traditional search with 1000 iterations was performed in TNT. Branch support was investigated using the bootstrap method...
  90. Moxnes J, Frøyland Ã, Risdal T. A computational study of ANTA and NTO derivatives. J Mol Model. 2017;23:240 pubmed publisher
    ..RDX and TNT were studied for comparison...
  91. Jo W, Lee J, Chun H. Titania Nanotubes Grown on Carbon Fibers for Photocatalytic Decomposition of Gas-Phase Aromatic Pollutants. Materials (Basel). 2014;7:1801-1813 pubmed publisher
    This study aimed to prepare titania (TiO?) nanotube (TNT) arrays grown on un-activated carbon fibers (UCFs), with the application of different TiO? loadings based on the coating-hydrothermal process, and to evaluate their photocatalytic ..
  92. Zhang L, Liao X, Fok A, Ning C, Ng P, Wang Y. Effect of crystalline phase changes in titania (TiO2) nanotube coatings on platelet adhesion and activation. Mater Sci Eng C Mater Biol Appl. 2018;82:91-101 pubmed publisher
    ..874±1.660) nm for the un-annealed TNTs to (26.126±2.130) nm for the 550°C annealed TNTs...