TNNI3

Summary

Gene Symbol: TNNI3
Description: troponin I3, cardiac type
Alias: CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI, troponin I, cardiac muscle, cardiomyopathy, dilated 2A (autosomal recessive), troponin I type 3 (cardiac)
Species: human
Products:     TNNI3

Top Publications

  1. Doolan A, Tebo M, Ingles J, Nguyen L, Tsoutsman T, Lam L, et al. Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. J Mol Cell Cardiol. 2005;38:387-93 pubmed
    ..Cardiac troponin I (cTnI) is a key switch molecule in the sarcomere...
  2. Hunkeler N, Kullman J, Murphy A. Troponin I isoform expression in human heart. Circ Res. 1991;69:1409-14 pubmed
    ..We conclude that troponin I isoforms are developmentally regulated in the human heart by a mechanism similar to that in the rat heart. ..
  3. Kimura A, Harada H, Park J, Nishi H, Satoh M, Takahashi M, et al. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997;16:379-82 pubmed
    ..in cardiac muscle, we have systematically characterized the cardiac sarcomere genes, including cardiac troponin I (cTnI), cardiac actin (cACT) and cardiac troponin C (cTnC) in 184 unrelated patients with HCM and found mutations in the ..
  4. Richard P, Charron P, Carrier L, Ledeuil C, Cheav T, Pichereau C, et al. Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. Circulation. 2003;107:2227-32 pubmed
    ..The entire coding sequences of 9 genes (MYH7, MYBPC3, TNNI3, TNNT2, MYL2, MYL3, TPM1, ACTC, andTNNC1) were analyzed in 197 unrelated index cases with familial or sporadic ..
  5. Zhao Y, Meng X, Wei Y, Zhao X, Liu D, Cao H, et al. Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J Mol Med (Berl). 2003;81:297-304 pubmed
    ..Our data suggest that TNNI3K is a cardiac-specific kinase and play important roles in cardiac system. ..
  6. Erdmann J, Daehmlow S, Wischke S, Senyuva M, Werner U, Raible J, et al. Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy. Clin Genet. 2003;64:339-49 pubmed
    ..protein C3 (MYBPC3), MYH7, cardiac troponin T (TNNT2), alpha-tropomyosin (TPM1), cardiac troponin I (TNNI3), and cardiac troponin C (TNNC1)...
  7. Gomes A, Liang J, Potter J. Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J Biol Chem. 2005;280:30909-15 pubmed
    Human cardiac Troponin I (cTnI) is the first sarcomeric protein for which mutations have been associated with restrictive cardiomyopathy...
  8. You B, Yan G, Zhang Z, Yan L, Li J, Ge Q, et al. Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1. Biochem J. 2009;418:93-101 pubmed publisher
    ..The interaction of cTnI with Mst1 was confirmed by co-immunoprecipitation in both co-transfected HEK-293 cells (human embryonic kidney ..
  9. Bolliger D, Seeberger M, Lurati Buse G, Christen P, Rupinski B, Gurke L, et al. A preliminary report on the prognostic significance of preoperative brain natriuretic peptide and postoperative cardiac troponin in patients undergoing major vascular surgery. Anesth Analg. 2009;108:1069-75 pubmed publisher
    ..879-0.996). These data suggest that measurement of preoperative BNP concentrations in addition to postoperative cTn concentrations provides additive prognostic information for MACE and mortality after major vascular surgery. ..

More Information

Publications110 found, 100 shown here

  1. Kaski J, Syrris P, Esteban M, Jenkins S, Pantazis A, Deanfield J, et al. Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy. Circ Cardiovasc Genet. 2009;2:436-41 pubmed publisher
    ..The protein-coding sequences of 9 sarcomere protein genes (MYH7, MYBPC3, TNNI3, TNNT2, TPM1, MYL2, MYL3, ACTC, and TNNC1), the genes encoding desmin (DES), and the gamma-2 subunit of AMP kinase ..
  2. Hijazi Z, Siegbahn A, Andersson U, Granger C, Alexander J, Atar D, et al. High-sensitivity troponin I for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial. Circulation. 2014;129:625-34 pubmed publisher
    ..The benefits of apixaban in comparison with warfarin are consistent regardless of hs-TnI levels. http://www.clinicaltrials.gov. Unique identifier: NCT00412984. ..
  3. Noland T, Raynor R, Kuo J. Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites. J Biol Chem. 1989;264:20778-85 pubmed
  4. Bhavsar P, Brand N, Yacoub M, Barton P. Isolation and characterization of the human cardiac troponin I gene (TNNI3). Genomics. 1996;35:11-23 pubmed
    ..Here we describe the isolation and characterization of the human TnIc gene (HGMW-approved symbol TNNI3) and its promoter. The gene comprises eight exons contained within 6.2 kb of genomic DNA...
  5. Takeda S, Yamashita A, Maeda K, Maeda Y. Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form. Nature. 2003;424:35-41 pubmed
  6. Murphy R, Mogensen J, Shaw A, Kubo T, Hughes S, McKenna W. Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy. Lancet. 2004;363:371-2 pubmed
    ..identification of both dominant and recessive mutations to investigate the sarcomeric gene for cardiac troponin I (TNNI3) in 235 patients with dilated cardiomyopathy...
  7. Brobbey A, Ravakhah K. Elevated serum cardiac troponin I level in a patient after a grand mal seizure and with no evidence of cardiac disease. Am J Med Sci. 2004;328:189-91 pubmed
    ..5 ng/mL and 6.3 ng/mL. This case implies that troponin I can be significantly increased after a grand mal seizure, and with low clinical suspicion for myocardial injury this abnormality should be disregarded. ..
  8. Mogensen J, Murphy R, Kubo T, Bahl A, Moon J, Klausen I, et al. Frequency and clinical expression of cardiac troponin I mutations in 748 consecutive families with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2004;44:2315-25 pubmed
    ..of families with hypertrophic cardiomyopathy (HCM) caused by mutations in the gene for cardiac troponin I (TNNI3)...
  9. Kruger M, Zittrich S, Redwood C, Blaudeck N, James J, Robbins J, et al. Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils. J Physiol. 2005;564:347-57 pubmed
    ..of actomyosin ATPase partially reverses this shift, suggesting that the mutation impairs the normal function of cTnI to fully inhibit formation of force-generating crossbridges in the absence of Ca(2)(+)...
  10. Shmilovich H, Danon A, Binah O, Roth A, Chen G, Wexler D, et al. Autoantibodies to cardiac troponin I in patients with idiopathic dilated and ischemic cardiomyopathy. Int J Cardiol. 2007;117:198-203 pubmed
    ..IgG antibodies to TpnI are increased in a significant number of patients with both ICM and idiopathic DCM, yet it appears that these autoantibodies cannot bind heart muscle cells or influence [Ca2+]i transients. ..
  11. Engel P, Hinken A, Solaro R. Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments. J Mol Cell Cardiol. 2009;47:359-64 pubmed publisher
    ..and heart failure are associated with protein kinase C (PKC) dependent phosphorylation of cardiac troponin I (cTnI). We investigated the effect of phosphorylation of cTnI PKC sites S43, S45 and T144 under normal (pH 7...
  12. Carballo S, Robinson P, Otway R, Fatkin D, Jongbloed J, de Jonge N, et al. Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy. Circ Res. 2009;105:375-82 pubmed publisher
    ..known as a hypertrophic cardiomyopathy disease gene, but with no reported mutation in autosomal dominant DCM, is TNNI3 which encodes cardiac troponin I. To test TNNI3 as a candidate gene, a panel of 96 probands with DCM was analyzed...
  13. Sun Y, Wang G, Ji Z, Chao T, Liu Z, Wang X, et al. Three slow skeletal muscle troponin genes in small-tailed Han sheep (Ovis aries): molecular cloning, characterization and expression analysis. Mol Biol Rep. 2016;43:999-1010 pubmed publisher
    To explore the basic characteristics and expressing profile of the three slow skeletal muscle troponin genes TNNC1 (Troponin C type 1), TNNI1 (troponin I type 1) and TNNT1 (troponin T type 1)...
  14. Li M, Hwang P. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015;571:153-66 pubmed publisher
    ..The calcium-sensing component of the complex is troponin C, which is expressed from the TNNC1 gene in both cardiac muscle and slow-twitch skeletal muscle (identical transcript in both tissues) and the TNNC2 ..
  15. Baxley T, Johnson D, Pinto J, Chalovich J. Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT. Biochemistry. 2017;56:2928-2937 pubmed publisher
    ..Because Ca2+ gives full activation, in this situation, troponin must be capable of positioning tropomyosin in the active M state without the need for rigor myosin binding. ..
  16. Thompson B, Martindale J, Metzger J. Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca2+-sensitive myofilaments. Am J Physiol Heart Circ Physiol. 2016;311:H36-43 pubmed publisher
    ..As an inherited cardiomyopathy model, R193H cardiac troponin I (cTnI) transgenic myocytes showed significant decreased baseline sarcomere length and slowed relaxation that were rapidly ..
  17. Parmacek M, Solaro R. Biology of the troponin complex in cardiac myocytes. Prog Cardiovasc Dis. 2004;47:159-76 pubmed
    ..is composed of three distinct gene products: troponin C (cTnC), the 18-kD Ca(2+)-binding subunit; troponin I (cTnI), the approximately 23-kD inhibitory subunit that prevents contraction in the absence of Ca2+ binding to cTnC; and ..
  18. Cheng X, Gu X, Gao Q, Zong Q, Li X, Zhang Y. Effects of dexmedetomidine postconditioning on myocardial ischemia and the role of the PI3K/Akt-dependent signaling pathway in reperfusion injury. Mol Med Rep. 2016;14:797-803 pubmed publisher
    ..Post?reperfusion, lactate dehydrogenase (LDH), cardiac troponin I (cTnI), creatine kinase isoenzymes (CK?MB), superoxide dismutase (SOD) and malondialdehyde (MDA) serum levels were ..
  19. Ploski R, Rydzanicz M, Ksiazczyk T, Franaszczyk M, Pollak A, Kosińska J, et al. Evidence for troponin C (TNNC1) as a gene for autosomal recessive restrictive cardiomyopathy with fatal outcome in infancy. Am J Med Genet A. 2016;170:3241-3248 pubmed publisher
    ..cardiomyopathy is a rare form of pediatric cardiac disease, for which the known genes include MYH7, TNNT2, TNNI3, ACTC1, and DES...
  20. Aprahamian M, Tikunova S, Price M, Cuesta A, Davis J, Lindert S. Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders. J Chem Inf Model. 2017;: pubmed publisher
    ..Desirable are small chemical molecules that bind to the interface between cTnC and the cTnI switch peptide and exhibit calcium sensitizing properties by possibly stabilizing cTnC in an open conformation...
  21. Zhao Y, Cao H, Song Y, Feng Y, Ding X, Pang M, et al. Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system. Int J Mol Med. 2016;37:1511-20 pubmed publisher
    ..myosin binding protein C, cardiac (MYBPC3); lamin A/C (LMNA); troponin I type 3 (cardiac) (TNNI3); troponin T type 2 (cardiac) (TNNT2); actin, ?, cardiac muscle 1 (ACTC1); tropomyosin 1 (?) (TPM1); ..
  22. Zhong L, Zhan J, Luo J, Cheng X. [Effects of astragalus polysaccharide on cardiac dysfunction in rabbits with severe scald injury]. Zhonghua Shao Shang Za Zhi. 2017;33:668-676 pubmed publisher
    ..The morphology of myocardium was observed after HE staining. The serum content of cardiac troponin I (cTnI) was detected by enzyme-linked immunosorbent assay (ELISA)...
  23. Cheng Y, Tan J, Li H, Kong X, Liu Y, Guo R, et al. Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury. Biomed Pharmacother. 2018;98:308-317 pubmed publisher
    ..enzymes [creatine kinase (CK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and cardiac troponin I (cTnI)], oxidative stress [superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and nitric ..
  24. Basta G, Del Turco S, Marchi F, Navarra T, Battaglia D, Mercuri A, et al. Elevated soluble receptor for advanced glycation end product levels in patients with acute coronary syndrome and positive cardiac troponin I. Coron Artery Dis. 2011;22:590-4 pubmed publisher
    ..However, in the patients with NSTE-ACS, sRAGE levels were significantly higher in patients with cardiac troponin-I (cTnI) of more than or equal to 0.04 µg/l compared with those with cTnI of less than 0...
  25. Ather S, Hira R, Shenoy M, Fatemi O, Deswal A, Aguilar D, et al. Recurrent low-level troponin I elevation is a worse prognostic indicator than occasional injury pattern in patients hospitalized with heart failure. Int J Cardiol. 2013;166:394-8 pubmed publisher
    ..04ng/ml portends a poor prognosis. ..
  26. Audet G, Quinn C, Leon L. Point-of-care cardiac troponin test accurately predicts heat stroke severity in rats. Am J Physiol Regul Integr Comp Physiol. 2015;309:R1264-72 pubmed publisher
    ..We suggested previously that circulating cardiac troponin (cTnI) could serve as a robust biomarker of HS severity after heating...
  27. Goudarzi M, Fatemi I, Siahpoosh A, Sezavar S, Mansouri E, Mehrzadi S. Protective Effect of Ellagic Acid Against Sodium Arsenite-Induced Cardio- and Hematotoxicity in Rats. Cardiovasc Toxicol. 2018;18:337-345 pubmed publisher
    ..that SA-intoxicated rats display significantly higher levels of plasma cardiac markers (AST, CK-MB, LDH and cTnI) than normal control animals...
  28. Nunes J. Troponin I, but not BNP, is associated with phosphorus, calcium and vitamin D in stable coronary artery disease. Kidney Blood Press Res. 2013;37:43-7 pubmed publisher
    ..012 ng/ml, but not those having BNP >100 pg/mL, had higher plasma phosphorus, higher plasma calcium and lower plasma 25-OH vitamin D concentrations than those having cardiac troponin I ? 0.012 ng/ml (or BNP ? 100 pg/mL). ..
  29. Zhou F, Zhou C, Tian Y, Xiao A, Li P, Wang Y, et al. Diagnostic value of analysis of H-FABP, NT-proBNP, and cTnI in heart function in children with congenital heart disease and pneumonia. Eur Rev Med Pharmacol Sci. 2014;18:1513-6 pubmed
    ..expression of heart-fatty acid-binding protein (H-FABP), N-terminal pro-brain natriuretic peptide (NT-proBNP), and cTnI in children with congenital heart disease (CHD) and pneumonia, and evaluate its diagnostic value in heart failure (..
  30. Akila P, Vennila L. Chlorogenic acid a dietary polyphenol attenuates isoproterenol induced myocardial oxidative stress in rat myocardium: An in vivo study. Biomed Pharmacother. 2016;84:208-214 pubmed publisher
    ..aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and troponin T and I (cTnT, cTnI) in the serum...
  31. Dutton E, Dukes McEwan J, Cripps P. Serum cardiac troponin I in canine syncope and seizures. J Vet Cardiol. 2017;19:1-13 pubmed publisher
    To determine if serum cardiac troponin I (cTnI) concentration distinguishes between cardiogenic syncope and collapsing dogs presenting with either generalized epileptic seizures (both with and without cardiac disease) or vasovagal syncope...
  32. Sugawa S, Masuda I, Kato K, Yoshimura M. Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels. Sci Rep. 2018;8:5120 pubmed publisher
    ..By using cardiac troponin I (cTnI) as an indicator of cardiovascular disorder, we assessed whether cTnI was inversely associated with BNP in ..
  33. Kedar V, McDonough H, Arya R, Li H, Rockman H, Patterson C. Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc Natl Acad Sci U S A. 2004;101:18135-40 pubmed
    ..In cardiomyocytes, these processes may determine the balance between hypertrophic and antihypertrophic signals and the regulation of myocyte contractile responses in the setting of heart failure. ..
  34. Lupi A, Rognoni A, Lazzero M, Rolla R, Pergolini P, Bellomo G, et al. Below normal pre-procedural cardiac troponin I levels are associated with an adverse prognosis after percutaneous coronary interventions. EuroIntervention. 2016;11:1380-8 pubmed publisher
    ..We investigated the correlation between pre-procedural cTnI levels and major clinical adverse events at three years of follow-up in 1,063 consecutive stable CAD patients with ..
  35. Druey S, Wildi K, Twerenbold R, Jaeger C, Reichlin T, Haaf P, et al. Early rule-out and rule-in of myocardial infarction using sensitive cardiac Troponin I. Int J Cardiol. 2015;195:163-70 pubmed publisher
    ..develop and validate early rule-out and rule-in algorithms for AMI using a thoroughly-examined and commonly used s-cTnI assay in a prospective multicenter study including 2173 patients presenting to the emergency department with ..
  36. Liu X, Yuan L, Chen F, Zhang L, Chen X, Yang C, et al. Circulating miR-208b: A Potentially Sensitive and Reliable Biomarker for the Diagnosis and Prognosis of Acute Myocardial Infarction. Clin Lab. 2017;63:101-109 pubmed publisher
    ..05), and it was positively correlated with the levels of creatine kinase (CK)-MB and cardiac troponin I (cTnI) (p < 0.01)...
  37. Wang Y, Liu M, Li H, Zhang W, Gao Q, Li Z. [Effect of endomorphin-1 postconditioning against myocardial ischemia-reperfusion injury in rats and the role of Erk1/2 signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1028-1034 pubmed
    ..The hemodynamic indexes of the rats were recorded. After reperfusion, CK-MB, LDH, CTnI, MDA, IL-6, TNF-?, and SOD activities or contents were measured, the infarct size was determined, and the ..
  38. Ding W, Han L, Xiao Y, Mo Y, Yang J, Wang X, et al. Role of Whole-exome Sequencing in Phenotype Classification and Clinical Treatment of Pediatric Restrictive Cardiomyopathy. Chin Med J (Engl). 2017;130:2823-2828 pubmed publisher
    ..Cardiac troponin I (cTnI) mutation-caused myofibril Ca2+ hypersensitivity has been shown to be associated with impaired diastolic function...
  39. Jideama N, Noland T, Raynor R, Blobe G, Fabbro D, Kazanietz M, et al. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem. 1996;271:23277-83 pubmed
    ..The present study has demonstrated for the first time distinct specificities of PKC isozymes for phosphorylation of two physiological substrates in the myocardium, with functional consequences. ..
  40. Fellahi J, Hanouz J, Le Manach Y, Gué X, Monier E, Guillou L, et al. Simultaneous measurement of cardiac troponin I, B-type natriuretic peptide, and C-reactive protein for the prediction of long-term cardiac outcome after cardiac surgery. Anesthesiology. 2009;111:250-7 pubmed publisher
    ..Simultaneous measurement of cardiac troponin I, B-type natriuretic peptide, and C-reactive protein improves the risk assessment of long-term adverse cardiac outcome after cardiac surgery. ..
  41. Cavallini C, Verdecchia P, Savonitto S, Arraiz G, Violini R, Olivari Z, et al. Prognostic value of isolated troponin I elevation after percutaneous coronary intervention. Circ Cardiovasc Interv. 2010;3:431-5 pubmed publisher
    ..We evaluated the relation between isolated elevations of cardiac troponin I (cTnI) and all-cause mortality...
  42. Wang Q, Liang D, Wang F, Li W, Han Y, Zhang W, et al. Efficacy of electroacupuncture pretreatment for myocardial injury in patients undergoing percutaneous coronary intervention: A randomized clinical trial with a 2-year follow-up. Int J Cardiol. 2015;194:28-35 pubmed publisher
    ..The primary end point was the incidence of myocardial infarction type 4a (MI4a) based on serum cTnI values at 24h after PCI...
  43. BiaÅ‚ek S, Górko D, Zajkowska A, KoÅ‚towski Å, Grabowski M, Stachurska A, et al. Release kinetics of circulating miRNA-208a in the early phase of myocardial infarction. Kardiol Pol. 2015;73:613-9 pubmed
    The biochemical confirmation of myocardial infarction is based on cardiac troponin (cTnI or cTnT) determination. Recent scientific results suggested that microRNAs (miRNAs) might become a new biomarker of tissue injury...
  44. Martens R, Kimenai D, Kooman J, Stehouwer C, Tan F, Bekers O, et al. Estimated Glomerular Filtration Rate and Albuminuria Are Associated with Biomarkers of Cardiac Injury in a Population-Based Cohort Study: The Maastricht Study. Clin Chem. 2017;63:887-897 pubmed publisher
    ..associations of eGFR and urinary albumin excretion (UAE) with high-sensitivity cardiac troponin (hs-cTn) T, hs-cTnI, and N-terminal probrain natriuretic-peptide (NT-proBNP) in 3103 individuals from a population-based diabetes-..
  45. Jagodzinski A, Neumann J, Ojeda F, Sörensen N, Wild P, Munzel T, et al. Cardiovascular Biomarkers in Hypertensive Patients with Medical Treatment-Results from the Randomized TEAMSTA Protect I Trial. Clin Chem. 2017;: pubmed publisher
    ..We measured BP, high-sensitivity troponin I (hs-cTnI), high-sensitivity troponin T (hs-cTnT), B-type natriuretic peptide (BNP), and N-terminal-pro-BNP (NT-proBNP) ..
  46. Kadota C, Arimura T, Hayashi T, Naruse T, Kawai S, Kimura A. Screening of sarcomere gene mutations in young athletes with abnormal findings in electrocardiography: identification of a MYH7 mutation and MYBPC3 mutations. J Hum Genet. 2015;60:641-5 pubmed publisher
    ..with abnormal ECG findings were the subjects for the analysis of four sarcomere genes, MYH7, MYBPC3, TNNT2 and TNNI3. We found that 5 out of 102 (4...
  47. Boeddinghaus J, Reichlin T, Cullen L, Greenslade J, Parsonage W, Hammett C, et al. Two-Hour Algorithm for Triage toward Rule-Out and Rule-In of Acute Myocardial Infarction by Use of High-Sensitivity Cardiac Troponin I. Clin Chem. 2016;62:494-504 pubmed publisher
    ..Therefore, we aimed to develop a 2-h algorithm that uses high-sensitivity cardiac troponin I (hs-cTnI)...
  48. Jia K, Shi P, Han X, Chen T, Tang H, Wang J. Diagnostic value of miR-30d-5p and miR-125b-5p in acute myocardial infarction. Mol Med Rep. 2016;14:184-94 pubmed publisher
    ..Routine diagnostic parameters were assessed, including creatinine kinase MB, cardiac troponin I (cTnI) and myoglobin. A total of 33 miRNAs were differentially expressed in patients with AMI and healthy controls...
  49. Rahman M, Alam M, Jahan N, Shila J, Arslam M. Prognostic Role of Multiple Cardiac Biomarkers in Newly Diagnosed Acute Coronary Syndrome Patients. Mymensingh Med J. 2016;25:326-33 pubmed
    ..The aim of the study was to evaluate the prognostic role of serum cTnI, CK-MB, hsCRP, MPO and BNP in newly diagnosed acute coronary syndrome patients...
  50. Alghamry A, Hanna J, Pelecanos A, Kyranis S, Khelgi V, O Rourke P, et al. Predictors of significant coronary artery disease in atrial fibrillation: Are cardiac troponins a useful measure. Int J Cardiol. 2016;223:744-749 pubmed publisher
    Cardiac Troponin I (cTnI) is frequently measured in patients presenting with symptomatic atrial fibrillation (AF). The significance of elevated cTnI levels in this patient cohort is unclear...
  51. Patchell V, Gallon C, Hodgkin M, Fattoum A, Perry S, Levine B. The inhibitory region of troponin-I alters the ability of F-actin to interact with different segments of myosin. Eur J Biochem. 2002;269:5088-100 pubmed
    ..The data are discussed in the context of tropomyosin's ability to stabilize the actin filament and facilitate the transmission of the conformational change to actin monomers not in direct contact with troponin I. ..
  52. Wen Y, Xu Y, Wang Y, Pinto J, Potter J, Kerrick W. Functional effects of a restrictive-cardiomyopathy-linked cardiac troponin I mutation (R145W) in transgenic mice. J Mol Biol. 2009;392:1158-67 pubmed publisher
    ..These functional results help to explain the mechanisms by which these mutations give rise to a restrictive phenotype. ..
  53. McLeod C, Bos J, Theis J, Edwards W, Gersh B, Ommen S, et al. Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations. Am Heart J. 2009;158:799-805 pubmed publisher
    ..6). Myofilament-positive HC does not appear to represent a distinct clinical phenotypic entity as evidenced by specific histologic characteristics and septal shape. ..
  54. Liu M, Miao R, Guo X, Zhu L, Zhang H, Hou Q, et al. Saddle Pulmonary Embolism: Laboratory and Computed Tomographic Pulmonary Angiographic Findings to Predict Short-term Mortality. Heart Lung Circ. 2017;26:134-142 pubmed publisher
    ..RVa/LVa ratio), Mastora score, septal angle, N-terminal pro-brain natriuretic peptide and cardiac troponin I (cTnI) for detecting early mortality were 2.15, 2.13, 69%, 57°, 3036 pg/mL and 0.18ng/mL, respectively...
  55. Eggers K, Apple F, Lind L, Lindahl B. The applied statistical approach highly influences the 99th percentile of cardiac troponin I. Clin Biochem. 2016;49:1109-1112 pubmed publisher
    ..this analysis, we investigated to which extent different statistical methods might have bearing on the calculated cTnI 99th percentile...
  56. Baydin A, Amanvermez R, Çelebi H, Tunçel O, Demircan S. Pentraxin 3, ischemia-modified albumin, and myeloperoxidase in predicting a cardiac damage in acute carbon monoxide poisoning. Am J Emerg Med. 2016;34:1927-1930 pubmed publisher
    ..IMA), and myeloperoxidase (MPO) as an early biomarker for cardiac damage when compared to cardiac troponin I (cTnI) and creatine kinase-MB fraction (CK-MB) in adult patients with acute CO poisoning...
  57. Ha V, Viguiliouk E, Kendall C, Balachandran B, Jenkins D, Kavsak P, et al. Effect of a low glycemic index diet versus a high-cereal fibre diet on markers of subclinical cardiac injury in healthy individuals with type 2 diabetes mellitus: An exploratory analysis of a randomized dietary trial. Clin Biochem. 2017;: pubmed publisher
    ..we assessed the effect of a LGI compared with a high-cereal fibre diet on high-sensitivity cardiac troponin I (hs-cTnI) and galectin-3 in otherwise healthy individuals with T2DM in an exploratory analysis of a completed randomized ..
  58. Cardinaels E, Daamen M, Bekers O, ten Kate J, Niens M, van Suijlen J, et al. Clinical Interpretation of Elevated Concentrations of Cardiac Troponin T, but Not Troponin I, in Nursing Home Residents. J Am Med Dir Assoc. 2015;16:884-91 pubmed publisher
    Cardiac troponins T (cTnT) and I (cTnI) are the preferred biomarkers to detect myocardial damage...
  59. Nordin A, Svenungsson E, Björnådal L, Elvin K, Larsson A, Jensen Urstad K. Troponin I and echocardiography in patients with systemic sclerosis and matched population controls. Scand J Rheumatol. 2017;46:226-235 pubmed publisher
    ..of N-terminal prohormone brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin I (hs-cTnI) were tabulated. NT-proBNP and hs-cTnI levels were higher in SSc patients than controls...
  60. Sandoval Y, Smith S, Shah A, Anand A, Chapman A, Love S, et al. Rapid Rule-Out of Acute Myocardial Injury Using a Single High-Sensitivity Cardiac Troponin I Measurement. Clin Chem. 2017;63:369-376 pubmed publisher
    ..derivation (n = 1647) and validation (n = 2198) cohorts], where high-sensitivity cardiac troponin I (hs-cTnI) was measured on clinical indication...
  61. Guo M, Guo L, Weng Y. Implication of peripheral blood miRNA-124 in predicting acute myocardial infarction. Eur Rev Med Pharmacol Sci. 2017;21:1054-1059 pubmed
    ..Real-time PCR was used to test miRNA-124 level. ELISA was used to test serum troponin (cTnI) and creatine kinase-MB isoenzyme (CK-MB) levels. The correlation between miRNA-124, cTnI and CK-MB was analyzed...
  62. Loeb H, Liu J. Frequency, risk factors, and effect on long-term survival of increased troponin I following uncomplicated elective percutaneous coronary intervention. Clin Cardiol. 2010;33:E40-4 pubmed publisher
    The frequency, risk factors for, and effect on long-term survival of increased troponin I (cTnI) following elective, uncomplicated percutaneous coronary intervention (PCI) remains uncertain...
  63. Foster D, Noguchi T, VanBuren P, Murphy A, Van Eyk J. C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning. Circ Res. 2003;93:917-24 pubmed
    ..myocardial stunning is characterized by specific C-terminal proteolysis of the myofilament protein, troponin I (cTnI) that yields cTnI1-193...
  64. Kowlessur D, Tobacman L. Low temperature dynamic mapping reveals unexpected order and disorder in troponin. J Biol Chem. 2010;285:38978-86 pubmed publisher
    ..Finally, change in temperature prominently altered local folding stability, suggesting that troponin is an unusually mobile protein under physiological conditions. ..
  65. Assa S, Gansevoort R, Westerhuis R, Kobold A, Voors A, de Jong P, et al. Determinants and prognostic significance of an intra-dialysis rise of cardiac troponin I measured by sensitive assay in hemodialysis patients. Clin Res Cardiol. 2013;102:439-45 pubmed publisher
    Previous studies using conventional cTnI assays reported conflicting results on the evolution of cTnI levels during hemodialysis. The determinants and prognostic significance of changes in cTnI during hemodialysis are presently unknown...
  66. Storrow A, Nowak R, Diercks D, Singer A, Wu A, Kulstad E, et al. Absolute and relative changes (delta) in troponin I for early diagnosis of myocardial infarction: Results of a prospective multicenter trial. Clin Biochem. 2015;48:260-7 pubmed publisher
    ..Baseline TnI and absolute delta may be used in conjunction to estimate probability of MI. Consensus recommendations are supported for sampling on admission and 3h later, repeated at 6h in patients when clinical suspicion remains high. ..
  67. Benhamou Y, Boelle P, Baudin B, Ederhy S, Gras J, Galicier L, et al. Cardiac troponin-I on diagnosis predicts early death and refractoriness in acquired thrombotic thrombocytopenic purpura. Experience of the French Thrombotic Microangiopathies Reference Center. J Thromb Haemost. 2015;13:293-302 pubmed publisher
    ..Cardiac troponin-I measurement (cTnI) on admission could improve the early diagnosis of cardiac involvement and have prognostic value...
  68. Schlecht W, Dong W. Dynamic Equilibrium of Cardiac Troponin C's Hydrophobic Cleft and Its Modulation by Ca2+ Sensitizers and a Ca2+ Sensitivity Blunting Phosphomimic, cTnT(T204E). Bioconjug Chem. 2017;28:2581-2590 pubmed publisher
    ..Modulation of this equilibrium by Ca2+, cardiac troponin I (cTnI), cardiac troponin T (cTnT), Ca2+-sensitizers, and a Ca2+-desensitizing phosphomimic of cTnT (..
  69. Li X, Chen L, Guan Z, Luo Y, Cui Y, Liu R, et al. [Effect of neoflavonoid latifolin isolated from Dalbergia odorifera on acute myocardial ischemia in rats and its mechanism of Nrf2 signaling pathway]. Zhongguo Zhong Yao Za Zhi. 2017;42:3974-3982 pubmed publisher
    ..Further mechanism study showed that latifolin reduced cardiac troponin I(cTnI) level, aspartate transaminase(AST) and lactate dehydrogenase(LDH) activities in serum, increased myocardial ..
  70. Zhang Z, Akhter S, Mottl S, Jin J. Calcium-regulated conformational change in the C-terminal end segment of troponin I and its binding to tropomyosin. FEBS J. 2011;278:3348-59 pubmed publisher
    ..These results provided novel evidence for suggesting that the C-terminal end segment of TnI participates in the Ca(2+) regulation of muscle thin filament through interaction with tropomyosin. ..
  71. Fang X, Poulsen R, Wang Hu J, Shi O, Calvo N, Simmons C, et al. Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytes. FASEB J. 2016;30:3238-55 pubmed publisher
    ..Moreover, decreased methylation levels were found in the promoters of Myh7, Myh7b, Tnni3, and Tnnt2, consistent with the up-regulation of these genes by DNMT3a siRNA...
  72. Derar D, Ali A, Tharwat M, Al Sobayil F, Zeitoun M. Erectile dysfunction in male dromedary camels: Clinical findings and changes in the nitric oxide metabolite, cardiac troponin I and testosterone concentrations. Theriogenology. 2017;89:201-205 pubmed publisher
    ..ED) in male camels and monitor the associated changes in nitric oxide metabolite (NOM), cardiac troponin I (cTnI), and testosterone concentrations. A total 18 camels with ED and 10 controls were included in this study...
  73. Lang S, Stevenson T, Schatz T, Biesiadecki B, Westfall M. Secondary phosphorylation in myocytes expressing FLAG-tagged and non-tagged phospho-mimetic cardiac troponin I. Data Brief. 2017;15:562-566 pubmed publisher
    Secondary phosphorylation develops in myocytes expressing phospho-mimetic cardiac troponin I (cTnI) but it is not known whether multiple substitutions (e.g...
  74. Kavsak P, Worster A, Shortt C, Ma J, Clayton N, Sherbino J, et al. High-sensitivity cardiac troponin concentrations at emergency department presentation in females and males with an acute cardiac outcome. Ann Clin Biochem. 2017;:4563217743997 pubmed publisher
    Background There is interest in utilizing different cut-offs per sex for high-sensitivity cardiac troponin I (hs-cTnI) but less so for high-sensitivity cardiac troponin T (hs-cTnT) for patient management in the acute setting...
  75. Chong C, Lam Q, Ryan J, Sinnappu R, Lim W. Incidence of post-operative troponin I rises and 1-year mortality after emergency orthopaedic surgery in older patients. Age Ageing. 2009;38:168-74 pubmed publisher
    ..Future studies are needed to determine whether any intervention can improve outcome for these patients. ..
  76. Karfis E, Kontogiorgi P, Papadopoulos G, Tzimas P, Seferiadis C, Athanasulas C, et al. Cardiac valve surgery and myocardial damage: the role of cardiac troponin I. J Cardiovasc Surg (Torino). 2010;51:409-15 pubmed
    The study investigated the release of cardiac Troponin I (cTnI) levels in heart valve surgery and in coronary artery bypass grafting (CABG)...
  77. Lappe J, Pelfrey C, Cotleur A, Tang W. Cellular proliferative response to cardiac troponin-I in patients with idiopathic dilated cardiomyopathy. Clin Transl Sci. 2011;4:317-22 pubmed publisher
    ..patients with idiopathic dilated cardiomyopathy (iDCM) have autoantibodies (AAbs) specific to cardiac troponin-I (cTnI). However, there has been no work evaluating active cellular autoimmunity...
  78. Bradham W, Bian A, Oeser A, Gebretsadik T, Shintani A, Solus J, et al. High-sensitivity cardiac troponin-I is elevated in patients with rheumatoid arthritis, independent of cardiovascular risk factors and inflammation. PLoS ONE. 2012;7:e38930 pubmed publisher
    ..Elevated troponin concentrations in RA may indicate subclinical, indolent myocardial injury. ..
  79. Mylonas K, Tzani A, Metaxas P, Schizas D, Boikou V, Economopoulos K. Blood Versus Crystalloid Cardioplegia in Pediatric Cardiac Surgery: A Systematic Review and Meta-analysis. Pediatr Cardiol. 2017;38:1527-1539 pubmed publisher
    ..regimens, and perioperative outcomes as well as relevant biochemical markers, namely cardiac troponin I (cTnI), lactate, and ATP levels at baseline, after reperfusion and postoperatively at 1, 4, 12, and 24 h as applicable...
  80. Kerekanič M, Hudák M, Misíková S, Komanová E, Bohó A, Kyselovic J, et al. The prognostic value of high sensitive cardiac troponin I in patients receiving cardiac resynchronisation therapy. Acta Cardiol. 2017;:1-6 pubmed publisher
    Cardiac troponin I (cTnI) is a valuable prognostic biomarker in patients with chronic heart failure (CHF). However, the prognostic importance of cTnI in patients who received cardiac resynchronisation therapy (CRT) remains unknown...
  81. Galyfos G, Tsioufis C, Theodorou D, Katsaragakis S, Zografos G, Filis K. Cardiac troponin I after carotid endarterectomy in different cardiac risk patients. J Stroke Cerebrovasc Dis. 2015;24:711-7 pubmed publisher
    We compared postoperative cardiac damage, defined as cardiac troponin I (cTnI) elevation, in low, medium, and high cardiac risk patients, after carotid endarterectomy (CEA)...
  82. Cai F, Li M, Pineda Sanabria S, Gelozia S, Lindert S, WEST F, et al. Structures reveal details of small molecule binding to cardiac troponin. J Mol Cell Cardiol. 2016;101:134-144 pubmed publisher
    ..of the regulatory N-terminal domain of cardiac troponin C (cNTnC) fused to the switch region of cardiac troponin I (cTnI), mimicking the key binding event that turns on muscle contraction...
  83. Willeit P, Welsh P, Evans J, Tschiderer L, Boachie C, Jukema J, et al. High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants. J Am Coll Cardiol. 2017;70:558-568 pubmed publisher
    High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-cTnT) in individuals with no clinically manifest myocardial injury...
  84. Seyfeli E, Abaci A, Ekici E, Oguzhan A, Tokgoz B, Yalcin F, et al. The relationship between cardiac troponins and left ventricular mass index in patients with chronic renal failure. Ren Fail. 2008;30:976-81 pubmed publisher
    ..The abstract of this study was accepted as an oral presentation in the 10(th) Annual Meeting of the ESC Working Group on Echocardiography, December 6-9, 2006, Prague, Czech Republic. ..
  85. Solecki K, Dupuy A, Kuster N, Leclercq F, Gervasoni R, Macia J, et al. Kinetics of high-sensitivity cardiac troponin T or troponin I compared to creatine kinase in patients with revascularized acute myocardial infarction. Clin Chem Lab Med. 2015;53:707-14 pubmed publisher
    ..The key role of troponins in diagnosis of AMI is well established. Moreover, kinetics of troponin I (cTnI) and creatine kinase (CK) after AMI are correlated to the prognosis...
  86. Grobben R, Vrijenhoek J, Nathoe H, Den Ruijter H, van Waes J, Peelen L, et al. Clinical Relevance of Cardiac Troponin Assessment in Patients Undergoing Carotid Endarterectomy. Eur J Vasc Endovasc Surg. 2016;51:473-80 pubmed publisher
    ..The incidence of adverse cardiovascular events was significantly higher in patients with troponin elevation, which was mainly attributable to silent non-ST segment elevation MIs that occurred in the early post-operative phase. ..
  87. Bossard M, Thériault S, Aeschbacher S, Schoen T, Kunz S, von Rotz M, et al. Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population. Clin Res Cardiol. 2017;106:96-104 pubmed publisher
    Determinants of cardiomyocyte injury as quantified by high-sensitivity cardiac troponin I (cTnI) in young and healthy individuals, and sex-specific 99th percentiles are largely unknown...
  88. Karbasi S, Zaeemi M, Mohri M, Rashidlamir A, Moosavi Z. Effects of testosterone enanthate and resistance training on myocardium in Wistar rats; clinical and anatomical pathology. Andrologia. 2017;: pubmed publisher
    ..dehydrogenase (LDH) and creatine kinase MB (CK-MB) and serum level of creatinine, urea and cardiac troponin I (CTnI) were evaluated. After sacrifice, samples from myocardial muscle were collected for histopathology evaluation...
  89. Twerenbold R, Badertscher P, Boeddinghaus J, Nestelberger T, Wildi K, Puelacher C, et al. 0/1-Hour Triage Algorithm for Myocardial Infarction in Patients With Renal Dysfunction. Circulation. 2018;137:436-451 pubmed publisher
    ..assessed the diagnostic performance of the European Society of Cardiology 0/1-hour algorithm using hs-cTnT and hs-cTnI in patients with RD, defined as an estimated glomerular filtration rate <60 mL/min/1...
  90. Barta J, Toth A, Jaquet K, Redlich A, Edes I, Papp Z. Calpain-1-dependent degradation of troponin I mutants found in familial hypertrophic cardiomyopathy. Mol Cell Biochem. 2003;251:83-8 pubmed
    The mechanism by which mutations of the cardiac troponin I (cTnI) gene evoke familial hypertrophic cardiomyopathy (fHCM) is unknown...
  91. Gravning J, Ueland T, Mørkrid L, Endresen K, Aaberge L, Kjekshus J. Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris. Scand Cardiovasc J. 2008;42:214-21 pubmed publisher
    To investigate the prognostic importance of cardiac troponin I (cTnI) elevation after percutaneous coronary intervention (PCI) in different clinical settings...