TNNC1

Summary

Gene Symbol: TNNC1
Description: troponin C1, slow skeletal and cardiac type
Alias: CMD1Z, CMH13, TN-C, TNC, TNNC, troponin C, slow skeletal and cardiac muscles, cardiac troponin C, slow twitch skeletal/cardiac muscle troponin C, troponin C type 1 (slow)
Species: human
Products:     TNNC1

Top Publications

  1. Gahlmann R, Wade R, Gunning P, Kedes L. Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. J Mol Biol. 1988;201:379-91 pubmed
    We have isolated and sequenced the cDNAs for human slow and fast skeletal muscle troponin C (TnC). Each cDNA is encoded by one of the two TnC genes in the human genome...
  2. Takeda S, Yamashita A, Maeda K, Maeda Y. Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form. Nature. 2003;424:35-41 pubmed
    ..It consists of three subunits (TnT, TnC and TnI) and, together with tropomyosin, is located on the actin filament...
  3. Spyracopoulos L, Li M, Sia S, Gagné S, Chandra M, Solaro R, et al. Calcium-induced structural transition in the regulatory domain of human cardiac troponin C. Biochemistry. 1997;36:12138-46 pubmed
    While calcium binding to troponin C (TnC) triggers the contraction of both skeletal and cardiac muscle, there is clear evidence that different mechanisms may be involved...
  4. Wang X, Li M, Sykes B. Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil. J Biol Chem. 2002;277:31124-33 pubmed
    b>Cardiac troponin C (cTnC) is the Ca(2+)-dependent switch for contraction in heart muscle and a potential target for drugs in the therapy of heart failure...
  5. Li M, Saude E, Wang X, Pearlstone J, Smillie L, Sykes B. Kinetic studies of calcium and cardiac troponin I peptide binding to human cardiac troponin C using NMR spectroscopy. Eur Biophys J. 2002;31:245-56 pubmed
    Ca2+ and human cardiac troponin I (cTnI) peptide binding to human cardiac troponin C (cTnC) have been investigated with the use of 2D [1H,15N] HSQC NMR spectroscopy...
  6. Tikunova S, Liu B, Swindle N, Little S, Gomes A, Swartz D, et al. Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 2010;49:1975-84 pubmed publisher
    The calcium-dependent interactions between troponin C (TnC) and other thin and thick filament proteins play a key role in the regulation of cardiac muscle contraction...
  7. Lindert S, Kekenes Huskey P, Huber G, Pierce L, McCammon J. Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study. J Phys Chem B. 2012;116:8449-59 pubmed publisher
    Troponin C (TnC) is an important regulatory molecule in cardiomyocytes. Calcium binding to site II in TnC initiates a series of molecular events that result in muscle contraction...
  8. Genchev G, Kobayashi T, Lu H. Calcium induced regulation of skeletal troponin--computational insights from molecular dynamics simulations. PLoS ONE. 2013;8:e58313 pubmed publisher
    ..In skeletal troponin binding of calcium to sites I and II of the TnC subunit results in a set of structural changes in the troponin complex, displaces tropomyosin along the actin ..
  9. Dong W, Xing J, Ouyang Y, An J, Cheung H. Structural kinetics of cardiac troponin C mutants linked to familial hypertrophic and dilated cardiomyopathy in troponin complexes. J Biol Chem. 2008;283:3424-32 pubmed
    ..Both mutations appear to be antagonistic toward phosphorylation signaling between cTnI and cTnC. ..

More Information

Publications130 found, 100 shown here

  1. Liu H, Chu T, Chen L, Gui W, Zhu G. The cardiovascular toxicity of triadimefon in early life stage of zebrafish and potential implications to human health. Environ Pollut. 2017;231:1093-1103 pubmed publisher
    ..level of genes related to ATPase (atp2a1l, atp1b2b, atp1a3b), calcium channel (cacna1ab, cacna1da) and cardiac troponin C (tnnc1a) were significantly decreased after TF exposure...
  2. Sun Y, Wang G, Ji Z, Chao T, Liu Z, Wang X, et al. Three slow skeletal muscle troponin genes in small-tailed Han sheep (Ovis aries): molecular cloning, characterization and expression analysis. Mol Biol Rep. 2016;43:999-1010 pubmed publisher
    To explore the basic characteristics and expressing profile of the three slow skeletal muscle troponin genes TNNC1 (Troponin C type 1), TNNI1 (troponin I type 1) and TNNT1 (troponin T type 1)...
  3. Duan J, Yu Y, Li Y, Li Y, Liu H, Jing L, et al. Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos. Nanotoxicology. 2016;10:575-85 pubmed publisher
    ..atp1b2b, atp1a3b), calcium channel-related genes (cacna1ab, cacna1da) and the regulatory gene tnnc1a for cardiac troponin C. Moreover, the protein level of TNNT2 was decreased in a dose-dependent manner...
  4. Yao H, Yang L, Han Q, Wang L, Wu L, Zhang C, et al. Postconditioning with simvastatin decreases myocardial injury in rats following acute myocardial ischemia. Exp Ther Med. 2015;9:1166-1170 pubmed
    ..05). Therefore, postconditioning with simvastatin was shown to attenuate myocardial injury. The underlying mechanism may be associated with the downregulation of HMGB1 expression in the ischemic myocardium. ..
  5. Warren C, Karam C, Wolska B, Kobayashi T, de Tombe P, Arteaga G, et al. Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin I (K206I). Circ Cardiovasc Genet. 2015;8:765-73 pubmed publisher
    ..impairs the ability of the troponin I to inhibit ATPase activity in the absence of calcium-bound human cardiac troponin C. The ability of calcium-bound human cardiac troponin C to neutralize the inhibition of K206I was greater ..
  6. Zhao C, Andersen H, Ozyilmaz B, Ramaprabhu S, Pastorin G, Ho H. Spontaneous and specific myogenic differentiation of human mesenchymal stem cells on polyethylene glycol-linked multi-walled carbon nanotube films for skeletal muscle engineering. Nanoscale. 2015;7:18239-49 pubmed publisher
    ..Skeletal muscle-specific markers, fast skeletal troponin-C (TnC) and ryanodine receptor-1 (Ryr) were also significantly increased in the non-induced hMSCs on PEG-CNT films by RT-..
  7. Irie T, Sips P, Kai S, Kida K, Ikeda K, Hirai S, et al. S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. Circ Res. 2015;117:793-803 pubmed publisher
    ..S-nitrosylation, we uncovered major roles for protein S-nitrosylation, in general, and for phospholamban and cardiac troponin C S-nitrosylation, in particular, in βAR-dependent regulation of Ca(2+) homeostasis...
  8. González Martínez D, Johnston J, Landim Vieira M, Ma W, Antipova O, Awan O, et al. Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle. J Mol Cell Cardiol. 2018;123:26-37 pubmed publisher
    ..We used a murine model of hypertrophic cardiomyopathy (HCM) harboring a cardiac troponin C (cTnC) Ca2+-sensitizing mutation, Ala8Val in the regulatory N-domain...
  9. Mahmud Z, Zahran S, Liu P, Reiz B, Chan B, Roczkowsky A, et al. Structure and proteolytic susceptibility of the inhibitory C-terminal tail of cardiac troponin I. Biochim Biophys Acta Gen Subj. 2019;1863:661-671 pubmed publisher
    ..whereas the competing calcium-dependent binding of the switch region, cTnI146-158, by cardiac troponin C (cTnC) triggers contraction...
  10. Marques M, Pinto J, Moraes A, Iqbal A, de Magalhães M, Monteiro J, et al. Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion. J Biol Chem. 2017;292:2379-2394 pubmed publisher
    ..The Ca2+ sensor of the sarcomere, cardiac troponin C (cTnC), plays an important role in regulating muscle contraction...
  11. Zhu X, Xia B, Wu Y, Yang H, Li C, Li P. Fenobucarb induces heart failure and cerebral hemorrhage in zebrafish. Aquat Toxicol. 2019;209:34-41 pubmed publisher
    ..channel-related gene (scn5Lab), potassium channel-related gene (kcnq1), the regulatory gene (tnnc1a) for cardiac troponin C, and several apoptosis-related genes were significantly downregulated in zebrafish following BPMC exposure...
  12. Doronin D, Barykina N, Subach O, Sotskov V, Plusnin V, Ivleva O, et al. Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics. BMC Biotechnol. 2018;18:10 pubmed publisher
    ..calcium indicator (GECI), called NTnC, has a novel design with reduced size due to utilization of the troponin C (TnC) as a Ca2+-binding moiety inserted into the mNeonGreen fluorescent protein...
  13. Schuster F, Johannsen S, Isbary S, Türkmeneli I, Roewer N. In vitro effects of levosimendan on muscle of malignant hyperthermia susceptible and non-susceptible swine. BMC Anesthesiol. 2018;18:182 pubmed publisher
    ..By binding to cardiac troponin C the conformation of the calcium-troponin C complex is stabilized, which leads to acceleration of actin-..
  14. Johnson R, Fulcher L, Vang K, Palmer C, Grossoehme N, Spuches A. In depth, thermodynamic analysis of Ca2+ binding to human cardiac troponin C: Extracting buffer-independent binding parameters. Biochim Biophys Acta Proteins Proteom. 2019;1867:359-366 pubmed publisher
    ..These data were used to extract buffer-independent parameters for Ca2+ binding to human cardiac troponin C (hcTnC), an EF-hand containing protein required for heart muscle contraction...
  15. De Winter J, Joureau B, Sequeira V, Clarke N, van der Velden J, Stienen G, et al. Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene. Skelet Muscle. 2015;5:12 pubmed publisher
    ..It exerts its effect through binding to slow skeletal/cardiac troponin C. As slow skeletal/cardiac troponin C is also the dominant troponin C isoform in slow-twitch skeletal muscle ..
  16. Thompson B, Martindale J, Metzger J. Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca2+-sensitive myofilaments. Am J Physiol Heart Circ Physiol. 2016;311:H36-43 pubmed publisher
    ..W7 was used here because of its well-known Ca(2+) desensitizer biochemical effects at the level of cardiac troponin C. Acute treatment of adult cardiac myocytes with W7 caused a dose-dependent (1-10 ?M) decrease in ..
  17. Harwood C, Young I, Tikunov B, Hollingworth S, Baylor S, Rome L. Paying the piper: the cost of Ca2+ pumping during the mating call of toadfish. J Physiol. 2011;589:5467-84 pubmed publisher
    ..To test this, we determined the number of regulatory sites by measuring the concentration of troponin C (TNC) molecules, 33.8 μmol per kg wet weight...
  18. Potluri P, Chamoun J, Cooke J, Badr M, Guse J, Rayes R, et al. The concerted movement of the switch region of Troponin I in cardiac muscle thin filaments as tracked by conventional and pulsed (DEER) EPR. J Struct Biol. 2017;200:376-387 pubmed publisher
    ..switch region to TnC in the cardiac isoform is necessary for promoting the interaction between the regulatory switch helix with the N-lobe of cardiac Troponin C, which, unlike the skeletal isoform, is largely in a closed conformation.
  19. Li K, Methawasin M, Tanner B, Granzier H, Solaro R, Dong W. Sarcomere length-dependent effects on Ca2+-troponin regulation in myocardium expressing compliant titin. J Gen Physiol. 2019;151:30-41 pubmed publisher
    ..was to monitor how length-dependent Ca2+-induced conformational changes in the N domain of cardiac troponin C (cTnC) are modulated by myosin-actin cross-bridge (XB) interactions and increased titin compliance...
  20. Cai F, Li M, Pineda Sanabria S, Gelozia S, Lindert S, WEST F, et al. Structures reveal details of small molecule binding to cardiac troponin. J Mol Cell Cardiol. 2016;101:134-144 pubmed publisher
    ..troponin, we have designed a chimeric construct (cChimera) consisting of the regulatory N-terminal domain of cardiac troponin C (cNTnC) fused to the switch region of cardiac troponin I (cTnI), mimicking the key binding event that turns ..
  21. Bakker A, Cully T, Wingate C, Barclay C, Launikonis B. Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. J Gen Physiol. 2017;149:323-334 pubmed publisher
    ..Furthermore, we modeled Ca2+ binding to the main intracellular Ca2+ buffers of troponin C (TnC), parvalbumin, and the SR Ca2+ pump during Ca2+ release and found that the main effect of the ..
  22. Korte F, Feest E, Razumova M, Tu A, Regnier M. Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges. Am J Physiol Heart Circ Physiol. 2012;303:H863-70 pubmed publisher
    ..We used the L48Q cardiac troponin C (cTnC) variant, which has enhanced Ca(2+) binding affinity, to test the hypotheses that the intrinsic ..
  23. Shi W, Li S, Collins N, Cottee D, Bastian B, James A, et al. Peri-operative Levosimendan in Patients Undergoing Cardiac Surgery: An Overview of the Evidence. Heart Lung Circ. 2015;24:667-72 pubmed publisher
    ..Levosimendan is a calcium-sensitising ionodilator. By binding to cardiac troponin C and reducing its calcium-binding co-efficient, it enhances myofilament responsiveness to calcium and thus ..
  24. Williams M, Lehman S, Tardiff J, Schwartz S. Atomic resolution probe for allostery in the regulatory thin filament. Proc Natl Acad Sci U S A. 2016;113:3257-62 pubmed publisher
    ..known substitutions at the same residue, reside at a significant distance from the calcium binding site in cardiac troponin C, and do not affect either the binding pocket affinity or EF-hand structure of the binding domain...
  25. Park S, Li C, Ames J. Nuclear magnetic resonance structure of calcium-binding protein 1 in a Ca(2+) -bound closed state: implications for target recognition. Protein Sci. 2011;20:1356-66 pubmed publisher
    ..bound closed conformation of EF1 is reminiscent of Ca(2+) -bound EF-hands in a closed conformation found in cardiac troponin C and calpain...
  26. Wang J, Ge Q, Li J, Chen Z, Li J. Isolation and characterization of three skeletal troponin genes and association with growth-related traits in Exopalaemon carinicauda. Mol Biol Rep. 2019;46:705-718 pubmed publisher
    ..The troponin complex, composed of troponin T (TnT), troponin C (TnC) and troponin I (TnI), plays a vital role in the regulation of muscle contraction...
  27. Salhi H, Walton S, Hassel N, Brundage E, de Tombe P, Janssen P, et al. Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation. J Mol Cell Cardiol. 2014;76:257-64 pubmed publisher
    ..results demonstrate that Tyr-26 phosphorylation and pseudo-phosphorylation decrease calcium binding to troponin C (TnC) on the thin filament and calcium sensitivity of force development to a similar magnitude as TnI Ser-23/24 pseudo-..
  28. Nagy L, Pollesello P, Haikala H, Végh Ã, Sorsa T, Levijoki J, et al. ORM-3819 promotes cardiac contractility through Ca(2+) sensitization in combination with selective PDE III inhibition, a novel approach to inotropy. Eur J Pharmacol. 2016;775:120-9 pubmed publisher
    ..ORM-3819 binding to cardiac troponin C (cTnC) was confirmed by nuclear magnetic resonance spectroscopy, and a selective inhibition of the ..
  29. Davis J, Shettigar V, Tikunova S, Little S, Liu B, Siddiqui J, et al. Designing proteins to combat disease: Cardiac troponin C as an example. Arch Biochem Biophys. 2016;601:4-10 pubmed publisher
    ..We predict designer proteins will open doors for unprecedented personalized, and potentially, even generalized medicines as gene therapy or protein delivery techniques come to fruition. ..
  30. Schlecht W, Dong W. Dynamic Equilibrium of Cardiac Troponin C's Hydrophobic Cleft and Its Modulation by Ca2+ Sensitizers and a Ca2+ Sensitivity Blunting Phosphomimic, cTnT(T204E). Bioconjug Chem. 2017;28:2581-2590 pubmed publisher
    ..have suggested that conformational dynamics are important in the regulation of thin filament activation in cardiac troponin C (cTnC); however, little direct evidence has been offered to support these claims...
  31. Veltri T, de Oliveira G, Bienkiewicz E, Palhano F, Marques M, Moraes A, et al. Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C. Sci Rep. 2017;7:691 pubmed publisher
    The hypertrophic cardiomyopathy-associated mutant D145E, in cardiac troponin C (cTnC) C-domain, causes generalised instability at multiple sites in the isolated protein...
  32. Lehmann A, Boldt J, Lang J, Isgro F, Blome M. [Is levosimendan an inoprotective drug in patients with acute coronary syndrome undergoing surgical revascularization?]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2003;38:577-82 pubmed
    ..First, levosimendan acts as a positive inotropic agent by binding calcium dependently to cardiac troponin C. Second, levosimendan activates adenosine triphosphate-regulated potassium (K (ATP)) channels...
  33. Gilda J, Xu Q, Martinez M, Nguyen S, Chase P, Gomes A. The functional significance of the last 5 residues of the C-terminus of cardiac troponin I. Arch Biochem Biophys. 2016;601:88-96 pubmed publisher
    ..Mammalian two-hybrid studies showed that the interactions between cTnI mutants and cardiac troponin C (cTnC) or cardiac troponin T (cTnT) were impaired in Δ3 and Δ5 mutants when compared to wild-type ..
  34. Johnson K, Milner R, Crocker S. Extracellular matrix composition determines astrocyte responses to mechanical and inflammatory stimuli. Neurosci Lett. 2015;600:104-9 pubmed publisher
    ..e., scratch). ECM substrates selected were laminin (Ln), vitronectin (Vn), fibronectin (Fn) or Tenascin C (TnC)...
  35. Benbow J, Thompson K, Cope H, Brandon Warner E, Culberson C, Bossi K, et al. Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C/Toll-Like Receptor 4 Signaling. Am J Pathol. 2016;186:145-58 pubmed publisher
    ..Tenascin-C (TnC), an extracellular matrix protein, is transiently expressed during tissue injury and plays a role in fibrogenesis ..
  36. Radwanska A, Grall D, Schaub S, Divonne S, Ciais D, Rekima S, et al. Counterbalancing anti-adhesive effects of Tenascin-C through fibronectin expression in endothelial cells. Sci Rep. 2017;7:12762 pubmed publisher
    Cellular fibronectin (FN) and tenascin-C (TNC) are prominent development- and disease-associated matrix components with pro- and anti-adhesive activity, respectively...
  37. Sevrieva I, Knowles A, Kampourakis T, Sun Y. Regulatory domain of troponin moves dynamically during activation of cardiac muscle. J Mol Cell Cardiol. 2014;75:181-7 pubmed publisher
    ..We show that the C-terminal lobe of TnC (CTnC) does not move during activation, suggesting that CTnC, together with the coiled coil formed by the TnI and ..
  38. Zhao B, Wang M, Xu J, Li M, Yu Y. Identification of pathogenic genes and upstream regulators in age-related macular degeneration. BMC Ophthalmol. 2017;17:102 pubmed publisher
    ..After KEGG analysis, steroid biosynthesis is a significantly enriched pathway for DEGs. The expression of 8 genes (TNC, GRP, TRAF6, ADAMTS5, GPX3, FAP, DHCR7 and FDFT1) was detected...
  39. Song Y, Lu G, Zhang H, Zhong X, Cong X, Xue S, et al. Proteogenomic characterization and integrative analysis of glioblastoma multiforme. Oncotarget. 2017;8:97304-97312 pubmed publisher
    ..We further identified 14 differentially expressed genes with high-level protein modification, among which NES and TNC showed differential expression at the protein level...
  40. Julien O, Sun Y, Wang X, Lindhout D, Thiessen A, Irving M, et al. Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity. Biochemistry. 2008;47:597-606 pubmed
    ..We have characterized Phe-to-Trp mutants in the 'structural' C-domain of cardiac troponin C, designed to immobilize the indole ring in the hydrophobic core of the domain...
  41. Zot H, Hasbun J, Michell C, Landim Vieira M, Pinto J. Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C. Arch Biochem Biophys. 2016;601:97-104 pubmed publisher
    Higher affinity for TnI explains how troponin C (TnC) carrying a causative hypertrophic cardiomyopathy mutation, TnC(A8V), sensitizes muscle cells to Ca(2+). Muscle fibers reconstituted with TnC(A8V) require ∼2...
  42. Dewan S, McCabe K, Regnier M, McCulloch A, Lindert S. Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study. J Phys Chem B. 2016;120:8264-75 pubmed publisher
    Mutations in cardiac troponin C (D75Y, E59D, and G159D), a key regulatory protein of myofilament contraction, have been associated with dilated cardiomyopathy (DCM)...
  43. Baum F, Sanders D, Fisher M, Anaf J, Freudenberg N, Friel S, et al. Assessing the health impact of transnational corporations: its importance and a framework. Global Health. 2016;12:27 pubmed publisher
    ..A framework to conduct the CHIA was developed and designed to be applied to a TNC's practices internationally, and within countries to enable comparison of practices and health impacts in different ..
  44. Murdamoothoo D, Schwenzer A, Kant J, Rupp T, Marzeda A, Midwood K, et al. Investigating cell-type specific functions of tenascin-C. Methods Cell Biol. 2018;143:401-428 pubmed publisher
    The extracellular matrix molecule tenascin-C (TNC) has received a lot of attention since its discovery 30 years ago because of its multiple roles in tissue repair, and in pathologies such as chronic inflammation, fibrosis, and cancer...
  45. Alkhudhairy F. The effects of irradiance and exposure time on the surface roughness of bulk-fill composite resin restorative materials. Saudi Med J. 2018;39:197-202 pubmed publisher
    ..Twenty-four specimens were prepared from each of the bulk-fill materials [Tetric N-Ceram (TNC), SonicFill (SF), Smart Dentin Replacement (SDR), and Filtek Bulk-Fill (FB)] using a brass metal mold, resulting in ..
  46. Ploski R, Rydzanicz M, Ksiazczyk T, Franaszczyk M, Pollak A, Kosińska J, et al. Evidence for troponin C (TNNC1) as a gene for autosomal recessive restrictive cardiomyopathy with fatal outcome in infancy. Am J Med Genet A. 2016;170:3241-3248 pubmed publisher
    ..proband with fatal restrictive cardiomyopathy associated with septal hypertrophy and compound heterozygosity for TNNC1 mutations (NM_003280: p.A8V [c.C23T] and p.D145E [c.C435A])...
  47. Costa Almeida R, Franco A, Pesqueira T, Oliveira M, Babo P, Leonor I, et al. The effects of platelet lysate patches on the activity of tendon-derived cells. Acta Biomater. 2018;68:29-40 pubmed publisher
    ..Cells were able to proliferate over time and an up-regulation of tenogenic genes (SCX, COL1A1 and TNC) was observed, suggesting that PL patches may modify the behavior of hTDCs...
  48. Swindle N, Albury A, Baroud B, Burney M, Tikunova S. Molecular and functional consequences of mutations in the central helix of cardiac troponin C. Arch Biochem Biophys. 2014;548:46-53 pubmed publisher
    ..Thus, our results indicate that conserved acidic residues within the exposed middle segment of the central helix of cTnC are important for the proper regulatory function of the cTn complex. ..
  49. Pollen A, Nowakowski T, Chen J, Retallack H, Sandoval Espinosa C, Nicholas C, et al. Molecular identity of human outer radial glia during cortical development. Cell. 2015;163:55-67 pubmed publisher
    ..glia preferentially express genes related to extracellular matrix formation, migration, and stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR...
  50. Olave N, Lal C, Halloran B, Pandit K, Cuna A, Faye Petersen O, et al. Regulation of alveolar septation by microRNA-489. Am J Physiol Lung Cell Mol Physiol. 2016;310:L476-87 pubmed publisher
    ..P42)], associated with decreases in its conserved target genes insulin-like growth factor-1 (Igf1) and tenascin C (Tnc)...
  51. Koshizuka K, Nohata N, Hanazawa T, Kikkawa N, Arai T, Okato A, et al. Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs. Oncotarget. 2017;8:30288-30304 pubmed publisher
    ..We identified that integrin α3 (ITGA3), integrin α6 (ITGA6), and tenascin C (TNC) were coordinately regulated by these miRNAs in HNSCC cells...
  52. Genge C, Stevens C, Davidson W, Singh G, Peter Tieleman D, Tibbits G. Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC. Genome Biol Evol. 2016;8:994-1011 pubmed publisher
    ..The cardiac troponin (Tn) complex, containing TnC, TnI, and TnT, forms a distinct functional unit critical for the regulation of cardiac muscle contraction...
  53. Zhu G, Mayer Wagner S, Schröder C, Woiczinski M, Blum H, Lavagi I, et al. Comparing effects of perfusion and hydrostatic pressure on gene profiles of human chondrocyte. J Biotechnol. 2015;210:59-65 pubmed publisher
    ..Despite of these similarities, RNAseq revealed a list of cartilage genes including ACAN, ITGA10 and TNC, which were differentially expressed by HPP and P...
  54. Kuroda H, Imai Y, Yamagishi H, Ueda Y, Kuroso K, Oishi Y, et al. Aberrant keratin 7 and 20 expression in triple-negative carcinoma of the breast. Ann Diagn Pathol. 2016;20:36-9 pubmed publisher
    ..Triple-negative carcinoma (TNC) has been characterized by negativity for estrogen receptor (ER), progesterone receptor (PgR), and Her2/neu protein...
  55. Sethi M, Thaysen Andersen M, Kim H, Park C, Baker M, Packer N, et al. Quantitative proteomic analysis of paired colorectal cancer and non-tumorigenic tissues reveals signature proteins and perturbed pathways involved in CRC progression and metastasis. J Proteomics. 2015;126:54-67 pubmed publisher
    ..Specifically, cancer associated proteins such as FN1, TNC, DEFA1, ITGB2, MLEC, CDH17, EZR and pathways including actin cytoskeleton and RhoGDI signaling were deregulated...
  56. Mansour R, Stamper L, Jaeger F, McGuire E, Fouda G, Amos J, et al. The Presence and Anti-HIV-1 Function of Tenascin C in Breast Milk and Genital Fluids. PLoS ONE. 2016;11:e0155261 pubmed publisher
    Tenascin-C (TNC) is a newly identified innate HIV-1-neutralizing protein present in breast milk, yet its presence and potential HIV-inhibitory function in other mucosal fluids is unknown...
  57. Cao H, Lu W, Tang K. Isolated talonavicular arthrodesis and talonavicular-cuneiform arthrodesis for the Müller-Weiss disease. J Orthop Surg Res. 2017;12:83 pubmed publisher
    ..Müller-Weiss disease were divided into the talonavicular (TN) arthrodesis group and the talonavicular-cuneiform (TNC) arthrodesis group according to the perinavicular osteoarthritis by MRI scans...
  58. Tomasselli A, Hui J, Adams L, Chosay J, Lowery D, Greenberg B, et al. Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus. J Biol Chem. 1991;266:14548-53 pubmed
  59. Song W, Van Keuren M, Drabkin H, Cypser J, Gemmill R, Kurnit D. Assignment of the human slow twitch skeletal muscle/cardiac troponin C gene (TNNC1) to human chromosome 3p21.3-->3p14.3 using somatic cell hybrids. Cytogenet Cell Genet. 1996;75:36-7 pubmed
  60. Castillo N, García Cadenas I, Barba P, Martino R, Azqueta C, Ferrà C, et al. Post-Thaw Viable CD45+ Cells and Clonogenic Efficiency are Associated with Better Engraftment and Outcomes after Single Cord Blood Transplantation in Adult Patients with Malignant Diseases. Biol Blood Marrow Transplant. 2015;21:2167-2172 pubmed publisher
    ..One hundred and ten patients from 3 institutions [median age, 35 years (range 18-55)] were included. Quantitative (TNC and total CD34+cells) and qualitative variables [viable CD45+ (vCD45+), vCD34+ and clonogenic efficiency [(CLONE), ..
  61. Cheng Y, Rao V, Tu A, Lindert S, Wang D, Oxenford L, et al. Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation. J Biol Chem. 2015;290:27749-66 pubmed publisher
    ..these regions may interact when Ser-23/Ser-24 are phosphorylated, weakening the interaction of cTnI with cardiac TnC. Little is known about how these mutations influence the affinity of cardiac TnC for cTnI (KC-I) or contractile ..
  62. Lussier J, Diouf M, Lévesque V, Sirois J, Ndiaye K. Gene expression profiling of upregulated mRNAs in granulosa cells of bovine ovulatory follicles following stimulation with hCG. Reprod Biol Endocrinol. 2017;15:88 pubmed publisher
    ..CRISPLD2, FKBP5, GFPT2, KIT, KITLG, L3MBLT3, MRO, NUDT10, NUDT11, P4HA3, POSTN, PSAP, RBP1, SAT1, SDC4, TIMP2, TNC and USP53...
  63. Das D, Kar D. Investigation of the vertical electrical transport in a-Si:H/nc-Si:H superlattice thin films. Phys Chem Chem Phys. 2015;17:17063-8 pubmed publisher
    ..silicon nano-crystallites (Si-ncs) has been realized simply by controlling the thickness of the nc-Si:H sub-layer (tnc) in the a-Si:H/nc-Si:H superlattice thin films grown by low temperature plasma processing in PE-CVD...
  64. Hagedorn M, Siegfried G, Hooks K, Khatib A. Integration of zebrafish fin regeneration genes with expression data of human tumors in silico uncovers potential novel melanoma markers. Oncotarget. 2016;7:71567-71579 pubmed publisher
    ..Whereas the role of TNC (tenascin C) and FN1 (fibronectin 1) in melanoma development is well documented, implication of MARCKS, RCN3, BAMBI,..
  65. Gocheva V, Naba A, Bhutkar A, Guardia T, Miller K, Li C, et al. Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival. Proc Natl Acad Sci U S A. 2017;114:E5625-E5634 pubmed publisher
    ..indicated significantly increased abundance of several S100 proteins, including Fibronectin and Tenascin-C (Tnc), in primary lung tumors and associated lymph node metastases compared with normal tissue...
  66. Pesqueira T, Costa Almeida R, Gomes M. Uncovering the effect of low-frequency static magnetic field on tendon-derived cells: from mechanosensing to tenogenesis. Sci Rep. 2017;7:10948 pubmed publisher
    ..stimulation in short-term studies significantly upregulated the expression of tendon-associated genes SCX, COL1A1, TNC and DCN (p < 0.05) and altered intracellular Ca2+ levels (p < 0.05)...
  67. Gan J, Yap A, Cheong J, Arista N, Tan C. Bulk-Fill Composites: Effectiveness of Cure With Poly- and Monowave Curing Lights and Modes. Oper Dent. 2017;: pubmed publisher
    ..The bulk-fill composites evaluated were Tetric N-Ceram bulk-fill (TNC), which contained a novel germanium photoinitiator (Ivocerin), and Smart Dentin Replacement (SDR)...
  68. Redwood C, Lohmann K, Bing W, Esposito G, Elliott K, Abdulrazzak H, et al. Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein. Circ Res. 2000;86:1146-52 pubmed
    ..Further, these findings underscore the importance of studying mixed mutant:wild-type preparations to faithfully model this autosomal-dominant disease. ..
  69. Gomez J, Lorca R, Reguero J, Moris C, Martin M, Tranche S, et al. Screening of the Filamin C Gene in a Large Cohort of Hypertrophic Cardiomyopathy Patients. Circ Cardiovasc Genet. 2017;10: pubmed publisher
    ..semiconductor chip technology) for the MYH7, MYBPC3, TNNT2, TNNI3, ACTC1, TNNC1, MYL2, MYL3, TPM1, and FLNC genes...
  70. Haji Momenian S, Parkinson W, Khati N, Brindle K, Earls J, Zeman R. Single-energy non-contrast hepatic steatosis criteria applied to virtual non-contrast images: is it still highly specific and positively predictive?. Clin Radiol. 2018;73:594.e7-594.e15 pubmed publisher
    ..Forty-eight computed tomography (CT) examinations, which included single-energy non-contrast (TNC) and contrast-enhanced dual-energy CT angiography (CTA) of the abdomen, were enrolled...
  71. Grand R, Levine B, Perry S. Proton-magnetic-resonance studies on the interaction of rabbit skeletal-muscle troponin I with troponin C and actin. Biochem J. 1982;203:61-8 pubmed
    ..6. It is concluded that actin interacts with the C-terminal region of peptide CN4, whereas troponin C interacts with the N-terminal region of peptide CN4 and with peptide CN5. ..
  72. Vassylyev D, Takeda S, Wakatsuki S, Maeda K, Maeda Y. Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution. Proc Natl Acad Sci U S A. 1998;95:4847-52 pubmed
    Troponin (Tn), the complex of three subunits (TnC, TnI, and TnT), plays a key role in Ca2+-dependent regulation of muscle contraction...
  73. Robertson I, Sevrieva I, Li M, Irving M, Sun Y, Sykes B. The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q. J Mol Cell Cardiol. 2015;87:257-69 pubmed publisher
    ..The mutation L29Q, found in the Ca(2+)-binding regulatory protein in heart muscle, cardiac troponin C (cTnC), has been linked to cardiac hypertrophy...
  74. Richardson J, Gauert A, Briones Montecinos L, Fanlo L, Alhashem Z, Assar R, et al. Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration. Cell Rep. 2016;15:2076-88 pubmed publisher
    ..In contrast, laser ablation of trunk NC (TNC) cells shows that leader cells direct movement and cell-cell contacts are required for migration...
  75. Yang Z, Ni W, Cui C, Fang L, Xuan Y. Tenascin C is a prognostic determinant and potential cancer-associated fibroblasts marker for breast ductal carcinoma. Exp Mol Pathol. 2017;102:262-267 pubmed publisher
    Tenascin C (TNC) is a key of extracellular matrix glycoprotein and highly express in numerous human malignancies...
  76. Cassar Malek I, Boby C, Picard B, Reverter A, Hudson N. Molecular regulation of high muscle mass in developing Blonde d'Aquitaine cattle foetuses. Biol Open. 2017;6:1483-1492 pubmed publisher
    ..muscle phenotype in the MSTN mutant BA is detectable through downregulation of various slow twitch subunits (TNNC1, MYH7, TPM3, CSRP3) beyond 210 dpc, and a small but consistent genome-wide reduction in ..
  77. Arata T, Nakamura M, Ueki S, Sugata K, Aihara T, Ueda K, et al. Dynamic structures of motor proteins myosin and kinesin, and switch protein troponin as detected by SDSL-ESR. J Electron Microsc (Tokyo). 2005;54 Suppl 1:i47-51 pubmed
    ..Spin dipole-dipole interaction showed that in reconstituted muscle fibers both skeletal and cardiac TnC undergo Ca2+-induced structural change that is thought to be essential for TnIreg movement...
  78. Schmidtmann A, Lindow C, Villard S, Heuser A, Mugge A, Gessner R, et al. Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C. FEBS J. 2005;272:6087-97 pubmed
    We investigated structural and functional aspects of the first mutation in TNNC1, coding for the calcium-binding subunit (cTnC) of cardiac troponin, which was detected in a patient with hypertrophic cardiomyopathy [ Hoffmann B, Schmidt-..
  79. Biesiadecki B, Kobayashi T, Walker J, Solaro R, de Tombe P. The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Circ Res. 2007;100:1486-93 pubmed
    Striated muscle contraction is regulated by the binding of Ca(2+) to the N-terminal regulatory lobe of the cardiac troponin C (cTnC) subunit in the troponin complex...
  80. Ni W, Yang Z, Cui C, Cui Y, Fang L, Xuan Y. Tenascin-C is a potential cancer-associated fibroblasts marker and predicts poor prognosis in prostate cancer. Biochem Biophys Res Commun. 2017;486:607-612 pubmed publisher
    Tenascin-C (TNC), as a member of the extracellular matrix (ECM), plays an important role in cancer cell proliferation and migration and tumor invasion in various types of cancer...
  81. Seghezzi M, Manenti B, Previtali G, Alessio M, Dominoni P, Buoro S. Preliminary evaluation of UF-5000 Body Fluid Mode for automated cerebrospinal fluid cell counting. Clin Chim Acta. 2017;473:133-138 pubmed publisher
    ..For total nucleated cells (TNC-UF) and white blood cells (WBC-UF) LoB, LoD and LoQ were 1×106cells/L, 1...
  82. Matsuo T, Tominaga T, Kono F, Shibata K, Fujiwara S. Modulation of the picosecond dynamics of troponin by the cardiomyopathy-causing mutation K247R of troponin T observed by quasielastic neutron scattering. Biochim Biophys Acta Proteins Proteom. 2017;1865:1781-1789 pubmed publisher
    Troponin (Tn), consisting of three subunits (TnC, TnI, and TnT), regulates cardiac muscle contraction in a Ca2+-dependent manner...
  83. Aksu T, Ok Bozkaya İ, Akpinar Tekgündüz S, Olcar Kanbur M, Köksal Y, Ozguner M, et al. Two versus three day upfront use of granulocyte-colony stimulating factor in healthy bone marrow donors for pediatric bone marrow transplantation. Transfus Apher Sci. 2017;56:829-831 pubmed publisher
    ..In addition, the number of total nucleated cells (TNC) harvested from BM were similar with two or three day regimen...
  84. Lan H, Hong X, Huang R, Lin X, Li Q, Li K, et al. RNA interference-mediated knockdown and virus-induced suppression of Troponin C gene adversely affect the behavior or fitness of the green rice leafhopper, Nephotettix cincticeps. Arch Insect Biochem Physiol. 2017;: pubmed publisher
    ..Behavior or fitness regulation of insect by modulating the Troponin C (TnC) may be a novel strategy in the comprehensive management of the insect pest...
  85. Kowlessur D, Tobacman L. Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy. J Biol Chem. 2012;287:42299-311 pubmed publisher
    ..To investigate this process, regulatory site Ca(2+) binding in the NH(2)-lobe of subunit troponin C (TnC) was abolished by mutagenesis, and effects on cardiac troponin dynamics were mapped by hydrogen-deuterium exchange (..
  86. Li M, Hwang P. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015;571:153-66 pubmed publisher
    ..b>Cardiac troponin C (cTnC) is made up of two globular EF-hand domains connected by a flexible linker...
  87. Anderson J, Seol H, Gordish Dressman H, Hathout Y, Spurney C. Interleukin 1 Receptor-Like 1 Protein (ST2) is a Potential Biomarker for Cardiomyopathy in Duchenne Muscular Dystrophy. Pediatr Cardiol. 2017;38:1606-1612 pubmed publisher
    ..01). Among a selected set of potential biomarkers for cardiomyopathy (MMP9, BNP, GAL3, CRP, LEP, TNC, TLR4 and ST2) we validated ST2 as significantly elevated in the serum of DMD cardiomyopathy group (35,798 ± ..
  88. Wu B, Wang S, Qin G, Xie J, Tan G, Zhou J, et al. Protein Kinase C ? Contributes to Central Sensitization in a Rat Model of Chronic Migraine. J Mol Neurosci. 2017;63:131-141 pubmed publisher
    ..staining were performed to detect the expression and location of PKC? in the trigeminal nucleus caudalis (TNC) and the expressions of calcitonin gene-related peptide (CGRP), c-Fos, and phosphorylation level of GluR1 subunit ..
  89. Cai J, Du S, Wang H, Xin B, Wang J, Shen W, et al. Tenascin-C induces migration and invasion through JNK/c-Jun signalling in pancreatic cancer. Oncotarget. 2017;8:74406-74422 pubmed publisher
    Tenascin-C (TNC), a large extracellular matrix glycoprotein, has been reported to be associated with metastasis and poor prognosis in pancreatic cancer...
  90. Song Y, Kim S, Heller M. An Implantable Transparent Conductive Film with Water Resistance and Ultra-bendability for Electronic Devices. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..To show the mechanical strength of AgNW onto transparent nitrocellulose (AgNW/TNC), it is tested by applying diverse mechanical stress, such as a binding test (3M peel-off), compressing, bending, ..
  91. Abbadi D, Laroumanie F, Bizou M, Pozzo J, Daviaud D, Delage C, et al. Local production of tenascin-C acts as a trigger for monocyte/macrophage recruitment that provokes cardiac dysfunction. Cardiovasc Res. 2017;: pubmed publisher
    Tenascin-C (TNC) is an endogenous danger signal molecule strongly associated with inflammatory diseases and with poor outcome in patients with cardiomyopathies...
  92. Matsui Y, Hasegawa M, Iino T, Imanaka Yoshida K, Yoshida T, Sudo A. Tenascin-C Prevents Articular Cartilage Degeneration in Murine Osteoarthritis Models. Cartilage. 2018;9:80-88 pubmed publisher
    Objective The objective of this study was to determine whether intra-articular injections of tenascin-C (TNC) could prevent cartilage damage in murine models of osteoarthritis (OA)...