TNFRSF12A

Summary

Gene Symbol: TNFRSF12A
Description: TNF receptor superfamily member 12A
Alias: CD266, FN14, TWEAKR, tumor necrosis factor receptor superfamily member 12A, FGF-inducible 14, fibroblast growth factor-inducible immediate-early response protein 14, tweak-receptor, type I transmembrane protein Fn14
Species: human
Products:     TNFRSF12A

Top Publications

  1. Feng S, Guo Y, Factor V, Thorgeirsson S, Bell D, Testa J, et al. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. Am J Pathol. 2000;156:1253-61 pubmed
    ..factor (FGF)-inducible genes in murine NIH 3T3 cells and recently reported that one of them, the FGF-inducible 14 (Fn14) immediate-early response gene, is predicted to encode a novel, cell surface-localized type Ia transmembrane ..
  2. Tran N, McDonough W, Donohue P, Winkles J, Berens T, Ross K, et al. The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors. Am J Pathol. 2003;162:1313-21 pubmed
    ..One of the genes identified was Fn14, which encodes a cell surface receptor for the tumor necrosis factor superfamily member named TWEAK...
  3. Tran N, McDonough W, Savitch B, Fortin S, Winkles J, Symons M, et al. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. Cancer Res. 2006;66:9535-42 pubmed
    ..Our current report shows that the fibroblast growth factor-inducible 14 (Fn14), a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed at high levels in migrating glioma ..
  4. Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, et al. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation. 2009;119:2058-68 pubmed publisher
    ..Herein, we demonstrate that mouse and human cardiomyocytes express the TWEAK receptor Fn14...
  5. Whitsett T, CHENG E, Inge L, Asrani K, Jameson N, Hostetter G, et al. Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. Am J Pathol. 2012;181:111-20 pubmed publisher
    ..Herein, we show that fibroblast growth factor-inducible 14 (Fn14; TNFRSF12A) is frequently overexpressed in NSCLC tumors, and Fn14 levels correlate with p-EGFR expression...
  6. Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, et al. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol. 2003;170:341-8 pubmed
    ..However, the TWEAK receptor(s) that mediates these multiple death pathways remains to be identified...
  7. Brown S, Richards C, Hanscom H, Feng S, Winkles J. The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation. Biochem J. 2003;371:395-403 pubmed
    ..These results indicate that Fn14 is a functional TWEAK receptor that can associate with four distinct TRAF family members and stimulate the NF-kappaB transcription factor ..
  8. Willis A, Tran N, Chatigny J, Charlton N, Vu H, Brown S, et al. The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity. Mol Cancer Res. 2008;6:725-34 pubmed publisher
    ..We report a pivotal role for the fibroblast growth factor-inducible 14 (Fn14) receptor in this process...
  9. He F, Dang W, Saito K, Watanabe S, Kobayashi N, Güntert P, et al. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. Protein Sci. 2009;18:650-6 pubmed publisher
    b>Fn14 is the smallest member of the tumor necrosis factor (TNF) receptor superfamily, and specifically binds to its ligand, TWEAK (TNF-like weak inducer of apoptosis), which is a member of the TNF superfamily...

More Information

Publications136 found, 100 shown here

  1. Huang M, Narita S, Tsuchiya N, Ma Z, Numakura K, Obara T, et al. Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome. Carcinogenesis. 2011;32:1589-96 pubmed publisher
    Fibroblast growth factor-inducible 14 (Fn14), a transmembrane receptor binding to the multifunctional cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK), is known to modulate many cellular activities including cancer ..
  2. Wiley S, Cassiano L, Lofton T, Davis Smith T, Winkles J, Lindner V, et al. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity. 2001;15:837-46 pubmed
    ..We report cloning of a receptor for TWEAK (TweakR) from a human umbilical vein endothelial cell (HUVEC) library...
  3. Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, Okumura K. Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2002;299:488-93 pubmed
    ..Recently, fibroblast growth factor-inducible 14 (Fn14) has been identified to be a TWEAK receptor, which may be responsible for the proliferation of endothelial cells and angiogenesis...
  4. Campbell S, Michaelson J, Burkly L, Putterman C. The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. Front Biosci. 2004;9:2273-84 pubmed
    ..In this paper we review the possible roles of TWEAK/TWEAK receptor interactions in the pathogenesis of inflammatory and systemic autoimmune diseases, with particular focus on ..
  5. Tran N, McDonough W, Savitch B, Sawyer T, Winkles J, Berens M. The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression. J Biol Chem. 2005;280:3483-92 pubmed
    The Fn14 gene encodes a type Ia transmembrane protein that belongs to the tumor necrosis factor receptor superfamily...
  6. Meighan Mantha R, Hsu D, Guo Y, Brown S, Feng S, Peifley K, et al. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem. 1999;274:33166-76 pubmed
    ..Here, we report that the fibroblast growth factor-inducible-14 (Fn14) gene is a growth factor-regulated, immediate-early response gene expressed in a developmental stage- and adult ..
  7. Watts G, Tran N, Berens M, Bhattacharyya A, Nelson M, Montgomery E, et al. Identification of Fn14/TWEAK receptor as a potential therapeutic target in esophageal adenocarcinoma. Int J Cancer. 2007;121:2132-9 pubmed
    ..From the list of potential targets we selected TNFRSF12A/Fn14/TWEAK receptor, a tumor necrosis factor super-family receptor, for further validation based on its reported role in tumor ..
  8. Dharmapatni A, Smith M, Crotti T, Holding C, Vincent C, Weedon H, et al. TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis. Arthritis Res Ther. 2011;13:R51 pubmed publisher
    ..This study aimed to investigate TWEAK and TWEAK receptor (Fn14) expression in synovial tissue from patients with active and inactive rheumatoid arthritis (RA), ..
  9. Brown S, Hanscom H, Vu H, Brew S, Winkles J. TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules. Biochem J. 2006;397:297-304 pubmed
    ..TWEAK binds with high affinity to a single TNF receptor super-family member, Fn14 (fibroblast growth factor-inducible 14)...
  10. Serafini B, Magliozzi R, Rosicarelli B, Reynolds R, Zheng T, Aloisi F. Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: implications for inflammatory tissue injury. J Neuropathol Exp Neurol. 2008;67:1137-48 pubmed publisher
    ..with proinflammatory and cell death-inducing activities, and its receptor, fibroblast growth factor-inducible 14 (Fn14), were examined in postmortem brain tissue samples from patients with multiple sclerosis (MS) and controls...
  11. Ikner A, Ashkenazi A. TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J Biol Chem. 2011;286:21546-54 pubmed publisher
    ..Consistent with earlier work, TWEAK assembled a proximal signaling complex containing its cognate receptor FN14, the adaptor TRAF2, and cellular inhibitor of apoptosis protein 1 (cIAP1)...
  12. Dohi T, Burkly L. The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases. J Leukoc Biol. 2012;92:265-79 pubmed publisher
    The TWEAK/Fn14 pathway is a ligand/receptor pair of the TNFSF that has emerged as a prominent player in normal and pathological tissue remodeling...
  13. Wang W, Liu H, Song M, Fang W, Yuan F. Clinical Effect of Cardiac Shock Wave Therapy on Myocardial Ischemia in Patients With Ischemic Heart Failure. J Cardiovasc Pharmacol Ther. 2016;21:381-7 pubmed publisher
    ..endothelial growth factor A [VEGF-A], VEGF-B, chemokine (C-X-C motif) ligand 1 [CXCL1], CXCL2, CXCL3 and TNFRSF12A) and a notable decrease in the expression of a mediator of cell apoptosis (mitogen-activated protein kinase 9)...
  14. Beetz N, Rommel C, Schnick T, Neumann E, Lother A, Monroy Ordonez E, et al. Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload. J Mol Cell Cardiol. 2016;101:145-155 pubmed publisher
    ..Putative downstream mediators of biglycan signaling include Rcan1, Abra and Tnfrsf12a. These genes were concordantly induced by TAC in WT but not in biglycan KO mice...
  15. Oarada M, Takahashi Nakaguchi A, Abe T, Nikawa T, Miki T, Gonoi T. Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice. Nutrition. 2015;31:757-65 pubmed publisher
    ..Inhbe), detoxification genes (Hmox1, Gsta1, Abca8b), genes involved in tissue regeneration (Gdf15, Krt23, Myc, Tnfrsf12a, Mthfd2), and genes involved in tumor suppression (p53, Txnrd1, Btg2)...
  16. Dong Y, Zhang Y, Xia L, Wang P, Chen J, Xu M, et al. The deposition of anti-DNA IgG contributes to the development of cutaneous lupus erythematosus. Immunol Lett. 2017;191:1-9 pubmed publisher
    ..anti-DNA IgG exaggerated both the expression and the activation of fibroblast growth factor inducible 14 (Fn14) in keratinocytes and regulated SOCS1 signals in a time-dependent manner...
  17. Carr D, Lau R, Hnatykiw A, Ward G, Daneshmand M, Cabrita M, et al. cIAP2 Is an Independent Signaling and Survival Factor during Mammary Lactational Involution and Tumorigenesis. J Mammary Gland Biol Neoplasia. 2018;23:109-123 pubmed publisher
    ..The TNF-related weak inducer of apoptosis (Tweak) which results in degradation of cIAP1 through its receptor, Fn14, began to increase in late lactation and was significantly increased in cIAP2-/- relative to WT mice by ..
  18. Asil M, Dertli R. Serum soluble TWEAK levels are decreased in treatment naive noncirrhotic chronic hepatitis B patients. Medicine (Baltimore). 2016;95:e4763 pubmed publisher
    ..studies with simultaneous determination of circulating sTWEAK concentrations and TWEAK and factor-inducible 14 (Fn14) expressions in the liver biopsy samples would clarify the exact association of TWEAK/Fn14 pathway in the ..
  19. Paul P, Bhatnagar S, Mishra V, Srivastava S, Darnay B, Choi Y, et al. The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms. Mol Cell Biol. 2012;32:1248-59 pubmed publisher
    ..suppresses the expression of key regulators of atrophy, including MAFBx, MuRF1, p62, LC3B, Beclin1, Atg12, and Fn14. Ablation of TRAF6 also improved the phosphorylation of Akt and FoxO3a and inhibited the activation of 5' AMP-..
  20. Mehta H, Mashiko S, Goulet P, Desjardins J, Perez G, Koenig M, et al. Dabigatran aggravates topoisomerase I peptide-loaded dendritic cells-induced lung and skin fibrosis. Clin Exp Rheumatol. 2017;35 Suppl 106:35-39 pubmed
    ..a profibrotic and inflammatory skin gene expression signature with upregulated expression of Col5a1, Timp1, Tweakr, Vwf, Il6, Il33, Il4 and Ifng...
  21. Dutt V, Saini V, Gupta P, Kaur N, Bala M, Gujar R, et al. S-allyl cysteine inhibits TNF?-induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules. Biochim Biophys Acta Gen Subj. 2018;1862:895-906 pubmed publisher
    ..namely TNF?, IL-6, IL-1?, TNF-like weak inducer of apoptosis (TWEAK), fibroblast growth factor-inducible 14 (Fn14) and Nox...
  22. Bathgate K, Bagley J, Jo E, Talmadge R, Tobias I, Brown L, et al. Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits. Eur J Appl Physiol. 2018;118:2097-2110 pubmed publisher
    ..fewer MHC IIa (fast-twitch) fibers, (4) greater AMPK protein expression, and (5) greater PAX7, IGF1Ec, IGF1Ea, and FN14 mRNA expression than UT...
  23. Ribeiro M, Guzzoni V, Hord J, Lopes G, Marqueti R, de Andrade R, et al. Resistance training regulates gene expression of molecules associated with intramyocellular lipids, glucose signaling and fiber size in old rats. Sci Rep. 2017;7:8593 pubmed publisher
    ..These responses were also linked to decreased catabolic (TNF-α, TWEAK/Fn14 axis; FOXO-1, Atrogin-1 and MuRF1; Myostatin) and increased anabolic intracellular pathways (IGF-1-mTOR-p70S6sk-1 ..
  24. Berzal S, González Guerrero C, Rayego Mateos S, Ucero Ã, Ocaña Salceda C, Egido J, et al. TNF-related weak inducer of apoptosis (TWEAK) regulates junctional proteins in tubular epithelial cells via canonical NF-κB pathway and ERK activation. J Cell Physiol. 2015;230:1580-93 pubmed publisher
    ..Mechanistically, the epithelial changes induced by TWEAK, including loss of epithelial integrity and EMT, via Fn14 were TGF-β1 independent, but mediated by several intracellular signaling systems, including the canonical NF-κ..
  25. Fayzullin A, Sandberg C, Spreadbury M, Saberniak B, Grieg Z, Skaga E, et al. Phenotypic and Expressional Heterogeneity in the Invasive Glioma Cells. Transl Oncol. 2019;12:122-133 pubmed publisher
    ..Cells of the invasive front expressed higher levels of CTGF, TNFRSF12A and genes involved in cell survival, migration and cell cycle pathways...
  26. Françoso A, Simioni P. Immunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trial monoclonal antibodies. Drug Des Devel Ther. 2017;11:177-184 pubmed publisher
    ..some recent molecules are in phase I and/or II trials and are yielding advantageous results, such as anti-DR5, anti-Fn14, anti-IGF-1R, anti-EGFR, anti-NRP1, and anti-A33 antibodies...
  27. Trappe S, Luden N, Minchev K, Raue U, Jemiolo B, Trappe T. Skeletal muscle signature of a champion sprint runner. J Appl Physiol (1985). 2015;118:1460-6 pubmed publisher
    ..responsive to intense exercise at the transcriptional level for genes involved with muscle growth and remodeling (Fn14 and myostatin)...
  28. Peng L, Li Q, Wang H, Wu J, Li C, Liu Y, et al. Fn14 deficiency ameliorates psoriasis-like skin disease in a murine model. Cell Death Dis. 2018;9:801 pubmed publisher
    ..TWEAK) is a multifunctional cytokine that acts through its receptor fibroblast growth factor-inducible 14 (Fn14). Recent studies demonstrated that the TWEAK/Fn14 signals participate in the development of psoriasis...
  29. Perez J, Tran N, Rosenblum M, Schneider C, Connolly N, Kim A, et al. The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics. Oncogene. 2016;35:2145-55 pubmed publisher
    Fibroblast growth factor-inducible 14 (Fn14; TNFRSF12A) is the cell surface receptor for the tumor necrosis factor (TNF) family member TNF-like weak inducer of apoptosis (TWEAK)...
  30. Lu J, Szeto C, Tam L, Lai F, Li E, Chow K, et al. Relationship of intrarenal gene expression and the histological class of lupus nephritis -- a study on repeat renal biopsy. J Rheumatol. 2012;39:1942-7 pubmed publisher
    To study the role of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)/Fn14 and the interferon-inducible protein (IP-10)/CXCR3 axis in lupus nephritis (LN)...
  31. Winer H, Fraiberg M, Abada A, Dadosh T, Tamim Yecheskel B, Elazar Z. Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins. Nat Commun. 2018;9:3744 pubmed publisher
    ..The TNF receptor Fn14 participates in multiple intracellular signaling pathways and is strongly induced upon tissue injury and solid ..
  32. Bowerman M, Salsac C, Coque E, Eiselt Ã, Deschaumes R, Brodovitch A, et al. Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis. Hum Mol Genet. 2015;24:3440-56 pubmed publisher
    ..Here, we report that the tumor necrosis factor-like weak inducer of apoptosis (Tweak) and its receptor Fn14 are aberrantly expressed in spinal astrocytes and skeletal muscle of SOD1(G93A) mice...
  33. Xu J, He J, He H, Peng R, Xi J. TWEAK-Fn14 Influences Neurogenesis Status via Modulating NF-?B in Mice with Spinal Cord Injury. Mol Neurobiol. 2017;54:7497-7506 pubmed publisher
    ..investigate the regulatory role of TNF-like weak inducer of apoptosis- fibroblast growth factor-inducible 14 (TWEAK-Fn14) pathway in nuclear factor-kappa B (NF-?B) expression and neurogenesis status after spinal cord injury (SCI)...
  34. Liu Y, Peng L, Li L, Liu C, Hu X, Xiao S, et al. TWEAK/Fn14 Activation Contributes to the Pathogenesis of Bullous Pemphigoid. J Invest Dermatol. 2017;137:1512-1522 pubmed publisher
    TWEAK participates in various cellular effects by engaging its receptor of Fn14. Increased levels of soluble TWEAK are associated with systemic autoimmunity in patients with lupus erythematosus, rheumatoid arthritis, or dermatomyositis...
  35. Cheng Q, Inaba Y, Lu P, Xu M, He J, Zhao Y, et al. Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity. Mol Endocrinol. 2015;29:571-82 pubmed publisher
    ..Our results also suggested that the fibroblast growth factor-inducible immediate-early response protein 14 (Fn14), a member of the proinflammatory TNF family, is a FXR-responsive gene...
  36. Roos A, Dhruv H, Mathews I, INGE L, Tuncali S, Hartman L, et al. Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells. Oncotarget. 2017;8:12234-12246 pubmed publisher
    ..superfamily, can stimulate glioma cell invasion and survival via binding to fibroblast growth factor-inducible 14 (Fn14) and subsequent activation of the transcription factor NF-κB...
  37. Gurunathan S, Winkles J, Ghosh S, Hayden M. Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem. 2014;289:12976-88 pubmed publisher
    Fibroblast growth factor-inducible 14 (Fn14) is a highly inducible cytokine receptor that engages multiple intracellular signaling pathways, including nuclear factor-?B (NF-?B) and mitogen-activated protein kinase (MAPK)...
  38. CHENG E, Whitsett T, Tran N, Winkles J. The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion. Mol Cancer Res. 2015;13:575-83 pubmed publisher
    The TNF receptor superfamily member Fn14 (TNFRSF12A) is the sole signaling receptor for the proinflammatory cytokine TWEAK (TNFSF12)...
  39. Wen J, Doerner J, Weidenheim K, Xia Y, Stock A, Michaelson J, et al. TNF-like weak inducer of apoptosis promotes blood brain barrier disruption and increases neuronal cell death in MRL/lpr mice. J Autoimmun. 2015;60:40-50 pubmed publisher
    ..Furthermore, knockout (KO) of the TWEAK receptor, Fn14, in the MRL/lpr lupus mouse strain markedly attenuates neuropsychiatric disease, as demonstrated by ..
  40. Valiño Rivas L, González Lafuente L, Sanz A, Ruiz Ortega M, Ortiz A, Sanchez Niño M. Non-canonical NF?B activation promotes chemokine expression in podocytes. Sci Rep. 2016;6:28857 pubmed publisher
    TNF-like weak inducer of apoptosis (TWEAK) receptor Fn14 is expressed by podocytes and Fn14 deficiency protects from experimental proteinuric kidney disease...
  41. Das N, Carpenter A, Yoshida T, Kumar S, Gautam S, Mostany R, et al. TRAF3IP2 mediates TWEAK/TWEAKR-induced pro-fibrotic responses in cultured cardiac fibroblasts and the heart. J Mol Cell Cardiol. 2018;121:107-123 pubmed publisher
    ..WEAK Inducer Of Apoptosis), a NF-?B- and/or AP-1-responsive proinflammatory cytokine that signals via TWEAK receptor (TWEAKR), is expressed at high levels in human and preclinical models of HF...
  42. Wang X, Zeng Y, Ho D, Yin J, Liu G, Chen X. Fibroblast Growth Factor-Inducible 14: Multiple Roles in Tumor Metastasis. Curr Mol Med. 2015;15:892-904 pubmed
    ..Fibroblast growth factor-inducible 14 (Fn14) is one member of the tumor necrosis factor receptor family, which is influential in controlling cell division, ..
  43. Di Martino L, Dave M, Menghini P, Xin W, Arseneau K, Pizarro T, et al. Protective Role for TWEAK/Fn14 in Regulating Acute Intestinal Inflammation and Colitis-Associated Tumorigenesis. Cancer Res. 2016;76:6533-6542 pubmed publisher
    ..In particular, TNF-like weak inducer of apoptosis (TWEAK) and its receptor, Fn14, are involved in normal and pathologic intestinal tissue remodeling...
  44. Zheng L, Lv Z, Gong Z, Sheng Q, Gao Z, Zhang Y, et al. Fn14 hepatic progenitor cells are associated with liver fibrosis in biliary atresia. Pediatr Surg Int. 2017;33:593-599 pubmed publisher
    ..fibrosis group (grade I-IV, BAa) and severe liver fibrosis group (grade V-VI, BAb) to detect Fn14 protein expression. In mRNA level, Fn14 expression was 21.23?±?8.3 vs. 1.00?±?0.17, p?=?0.023?<?0...
  45. Chang W, Yen M, Hung J, Yang C, Jian S, Yeh I, et al. Investigation of the role of tumor necrosis factor-like weak inducer of apoptosis in non-small cell lung cancer. Oncol Rep. 2018;39:573-581 pubmed publisher
    ..of apoptosis (TWEAK) is a member of the TNF superfamily and is a ligand of fibroblast growth factor inducible 14 (Fn14). TWEAK/Fn14 signaling pathways promote tumor progression in several types of human cancer...
  46. Roos A, Dhruv H, Peng S, INGE L, Tuncali S, Pineda M, et al. EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival. Mol Cancer Res. 2018;16:1185-1195 pubmed publisher
    ..of a previously established mediator of glioma cell invasion and survival: fibroblast growth factor-inducible 14 (Fn14)...
  47. Lassen U, Meulendijks D, Siu L, Karanikas V, Mau Sorensen M, Schellens J, et al. A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers. Clin Cancer Res. 2015;21:258-66 pubmed publisher
    ..necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor-inducible molecule 14 (Fn14) are a ligand-receptor pair frequently overexpressed in solid tumors...
  48. Hénaut L, Sanz A, Martin Sánchez D, Carrasco S, Villa Bellosta R, Aldamiz Echevarria G, et al. TWEAK favors phosphate-induced calcification of vascular smooth muscle cells through canonical and non-canonical activation of NFκB. Cell Death Dis. 2016;7:e2305 pubmed publisher
    ..TWEAK binding to its functional receptor Fn14 was reported to promote several steps of atherosclerotic plaque progression...
  49. Yadava R, Foff E, Yu Q, Gladman J, Kim Y, Bhatt K, et al. TWEAK/Fn14, a pathway and novel therapeutic target in myotonic dystrophy. Hum Mol Genet. 2015;24:2035-48 pubmed publisher
    ..Currently, no therapies exist. Here, we identify that fibroblast growth factor-inducible 14 (Fn14), a member of the tumor necrosis factor receptor super-family, is induced in skeletal muscles and hearts of mouse ..
  50. Cheadle L, Tzeng C, Kalish B, Harmin D, Rivera S, Ling E, et al. Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement. Neuron. 2018;99:525-539.e10 pubmed publisher
    ..We find that visual experience induces the expression of the cytokine receptor Fn14 in excitatory thalamocortical neurons...
  51. Xu W, Zhao Y, Liu Y. Role of the TWEAK/Fn14 pathway in autoimmune diseases. Immunol Res. 2016;64:44-50 pubmed publisher
    ..TWEAK signaling occurs via binding to Fn14, a type I transmembrane receptor belonging to the TNF receptor superfamily...
  52. Schneider C, Perez J, CHENG E, Zhang C, Mastorakos P, Hanes J, et al. Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells. Biomaterials. 2015;42:42-51 pubmed publisher
    ..to target invading GBM cells is via drug-loaded nanoparticles that bind to fibroblast growth factor-inducible 14 (Fn14), thereby potentially improving efficacy and reducing toxicity...
  53. Abu El Asrar A, De Hertogh G, Nawaz M, Siddiquei M, Van den Eynde K, Mohammad G, et al. The tumor necrosis factor superfamily members TWEAK, TNFSF15 and fibroblast growth factor-inducible protein 14 are upregulated in proliferative diabetic retinopathy. Ophthalmic Res. 2015;53:122-30 pubmed publisher
    ..TWEAK activity is mediated via binding to fibroblast growth factor-inducible molecule 14 (Fn14)...
  54. Boutaffala L, Bertrand M, Remouchamps C, Seleznik G, Reisinger F, Janas M, et al. NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis. Cell Death Differ. 2015;22:2020-33 pubmed publisher
    ..We show that NIK stabilization, obtained by activation of the non-death TNFRs Fn14 or LTβR, is required for TNFα-mediated apoptosis...
  55. Wang W, Liu F, Wang C, Wang C, Tang Y, Jiang Z. Src Promotes Metastasis of Human Non-Small Cell Lung Cancer Cells through Fn14-Mediated NF-?B Signaling. Med Sci Monit. 2018;24:1282-1294 pubmed
    BACKGROUND Src and Fn14 are implicated in the aggressiveness of non-small cell lung cancer (NSCLC) cells, yet the molecular mechanism is not fully understood...
  56. Henry K, Kellner D, Bajrami B, Anderson J, Beyna M, Bhisetti G, et al. CDK12-mediated transcriptional regulation of noncanonical NF-?B components is essential for signaling. Sci Signal. 2018;11: pubmed publisher
    ..inhibitor of the lymphotoxin ? receptor (LT?R), and tumor necrosis factor (TNF) receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52, but not of the TNF-? receptor-mediated nuclear translocation of p65...
  57. Park J, Kim S, Jung K, Lee J, Kwok S, Cho M, et al. Inhibition of the TWEAK/Fn14 pathway attenuates autoimmune arthritis in a SKG mouse model. Histol Histopathol. 2017;32:481-490 pubmed publisher
    ..To verify how TWEAK/fibroblast growth factor-inducible gene 14 (Fn14) signals affect development of Th17 cells in arthritis, we utilized the SKG mouse, which spontaneously develops ..
  58. Wang S, Jiang W, Chen X, Zhang C, Li H, Hou W, et al. Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma. J Hepatol. 2012;57:322-9 pubmed publisher
    ..RAR is able to interact with cytoplasmic AFP and binds to the element of the regulatory region of the Fn14 gene in the neoplastic tissue of HCC patients...
  59. Gomez I, Roach A, Nakagawa N, Amatucci A, Johnson B, Dunn K, et al. TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease. J Am Soc Nephrol. 2016;27:3639-3652 pubmed
    ..upregulated expression of TNF receptor superfamily member 12a, also known as fibroblast growth factor-inducible 14 (Fn14), by these cells...
  60. Hotta K, Sho M, Yamato I, Shimada K, Harada H, Akahori T, et al. Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury. Kidney Int. 2011;79:179-88 pubmed publisher
    ..The TWEAK receptor, fibroblast growth factor-inducible 14 (Fn14), has various unique functions under physiological and ..
  61. Wang J, Liu Y, Wei M, Mi X, Wang E. Clinical correlations and prognostic relevance of Fn14 expression in breast carcinoma. Histol Histopathol. 2013;28:859-64 pubmed publisher
    The aim of the present study was to clarify the expression of fibroblast growth factor-inducible 14 (Fn14), a type I transmembrane protein, in breast carcinoma and its correlation with clinicopathological features...
  62. Ensign S, Roos A, Mathews I, Dhruv H, Tuncali S, Sarkaria J, et al. SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide. Mol Cancer Res. 2016;14:302-12 pubmed publisher
    ..guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion. Here, further investigation revealed an important role for SGEF in glioma cell survival...
  63. Kums J, Nelke J, Rüth B, Schäfer V, Siegmund D, Wajant H. Quantitative analysis of cell surface antigen-antibody interaction using Gaussia princeps luciferase antibody fusion proteins. MAbs. 2017;9:506-520 pubmed publisher
    ..of SRP and flow cytometry in the characterization of cell surface antigen-specific antibodies, we developed Fn14-specific antibody 18D1 as an example of an antibody fusion protein format that includes the luciferase of Gaussia ..
  64. Fortin Ensign S, Mathews I, Eschbacher J, Loftus J, Symons M, Tran N. The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion. J Biol Chem. 2013;288:21887-97 pubmed publisher
    ..TNF-like weak inducer of apoptosis (TWEAK)-Fn14 ligand-receptor signaling is one mechanism in GB that promotes cell invasiveness and survival and is dependent upon ..
  65. Wen J, Chen C, Stock A, Doerner J, Gulinello M, Putterman C. Intracerebroventricular administration of TNF-like weak inducer of apoptosis induces depression-like behavior and cognitive dysfunction in non-autoimmune mice. Brain Behav Immun. 2016;54:27-37 pubmed publisher
    b>Fn14, the sole known signaling receptor for the TNF family member TWEAK, is inducibly expressed in the central nervous system (CNS) in endothelial cells, astrocytes, microglia, and neurons...
  66. Yadava R, Foff E, Yu Q, Gladman J, Zheng T, Mahadevan M. TWEAK Regulates Muscle Functions in a Mouse Model of RNA Toxicity. PLoS ONE. 2016;11:e0150192 pubmed publisher
    ..Previously, we found that fibroblast growth factor-inducible 14 (Fn14), the receptor for TWEAK, is induced in skeletal muscles and hearts of mouse models of RNA toxicity and that ..
  67. Liu Q, Xiao S, Xia Y. TWEAK/Fn14 Activation Participates in Skin Inflammation. Mediators Inflamm. 2017;2017:6746870 pubmed publisher
    ..in multiple biological activities via binding to its sole receptor-fibroblast growth factor-inducible 14 (Fn14)...
  68. Martínez Aranda A, Hernandez V, Moreno F, Baixeras N, Cuadras D, Urruticoechea A, et al. Predictive and Prognostic Brain Metastases Assessment in Luminal Breast Cancer Patients: FN14 and GRP94 from Diagnosis to Prophylaxis. Front Oncol. 2017;7:283 pubmed publisher
    b>FN14 has been implicated in many intracellular signaling pathways, and GRP94 is a well-known endoplasmic reticulum protein regulated by glucose. Recently, both have been associated with metastasis progression in breast cancer patients...
  69. Munoz Garcia B, Martin Ventura J, Martinez E, Sánchez S, Hernandez G, Ortega L, et al. Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. Stroke. 2006;37:2044-53 pubmed
    ..We have analyzed the expression of Fn14 and its ligand TWEAK in carotid atherosclerotic plaques and its potential modulation by atorvastatin in vivo...
  70. Xia L, Fang F, Lu J, Xiao W. [The expression of TWEAKR/Fn14 in Rheumatoid arthritis fibroblast-like synoviocytes]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010;26:575-7 pubmed
    To investigate the mechanism of TWEAK on Rheumatoid arthritis fibroblast-like synoviocytes (RA FLS) activation and articular destruction by analyzing expression of TWEAKR/Fn14 on RA FLS.
  71. Sanz Pamplona R, Aragues R, Driouch K, Martín B, Oliva B, Gil M, et al. Expression of endoplasmic reticulum stress proteins is a candidate marker of brain metastasis in both ErbB-2+ and ErbB-2- primary breast tumors. Am J Pathol. 2011;179:564-79 pubmed publisher
    ..A multivariate analysis based on stepwise logistic regression revealed GRP94, FN14, and inhibin as the best combination to discriminate between brain and non-brain metastases (ROC AUC = 0...
  72. Pellegrini M, Willen L, Perroud M, Krushinskie D, Strauch K, Cuervo H, et al. Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions. FEBS J. 2013;280:1818-29 pubmed publisher
    TWEAK (TNF homologue with weak apoptosis-inducing activity) and Fn14 (fibroblast growth factor-inducible protein 14) are members of the tumor necrosis factor (TNF) ligand and receptor super-families...
  73. Liu Y, Yuan C, Zhang S, Hao Q, Wang M, Zhang Z, et al. TWEAK/Fn14 signaling: a promising target in intervertebral disc degeneration. Histol Histopathol. 2016;31:943-8 pubmed publisher
    ..Remarkably, TWEAK and its receptors, fibroblast growth factor inducible 14 (Fn14), are also present in intervertebral disc (IVD) tissue, where they play a role in the pathogenesis of IVD ..
  74. Min H, Kim S, Park J, Byun J, Lee J, Kwok S, et al. Fn14-Fc suppresses germinal center formation and pathogenic B cells in a lupus mouse model via inhibition of the TWEAK/Fn14 Pathway. J Transl Med. 2016;14:98 pubmed publisher
    ..TNF-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) interactions mediate inflammatory responses that are linked to the pathogenesis of lupus nephritis...
  75. Guldiken N, Kobazi Ensari G, Lahiri P, Couchy G, Preisinger C, Liedtke C, et al. Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease. J Hepatol. 2016;65:552-9 pubmed publisher
    ..K23 levels correlated with the DR marker Fn14 and immunofluorescence staining showed a distinct co-localization with K7/K19...
  76. Yang B, Yan P, Gong H, Zuo L, Shi Y, Guo J, et al. TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner. Am J Transl Res. 2016;8:3848-3860 pubmed
    ..However, the role of TWEAK and its receptor Fn14 in the cardiomyocyte apoptosis is still poorly understood...
  77. Armstrong C, Galisteo R, Brown S, Winkles J. TWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion. Oncotarget. 2016;7:81474-81492 pubmed publisher
    ..TWEAK) is a multifunctional cytokine that binds with high affinity to a plasma membrane-anchored receptor named Fn14. Both TWEAK and Fn14 expression has been detected in human cancer tissue, and studies have shown that TWEAK/Fn14 ..
  78. Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, et al. Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. J Invest Dermatol. 2004;122:1175-9 pubmed
    ..Primary cultured normal human keratinocytes constitutively expressed a TWEAK receptor, fibroblast growth factor-inducible 14 (Fn14), and produced regulated on activation, normal T expressed and ..
  79. Affò S, Dominguez M, Lozano J, Sancho Bru P, Rodrigo Torres D, Morales Ibanez O, et al. Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis. Gut. 2013;62:452-60 pubmed publisher
    ..Importantly, Fn14 was the only TNF superfamily receptor exclusively upregulated in AH compared with other liver diseases and ..
  80. Liu Y, Liao W, Zhu Z, Zeng H, He H, Sun X, et al. Effect of procyanidine on VEGFR-2 expression and transduction pathway in rat endothelial progenitor cells under high glucose conditions. Genet Mol Res. 2016;15: pubmed publisher
    ..05) in HG + OPC EPCs. Therefore, procyanidin may promote cell proliferation by alleviating oxidative damage to EPCs under HG conditions, and upregulating VEGFR-2 expression and its downstream signal pathway. ..
  81. González Guerrero C, Cannata Ortiz P, Guerri C, Egido J, Ortiz A, Ramos A. TLR4-mediated inflammation is a key pathogenic event leading to kidney damage and fibrosis in cyclosporine nephrotoxicity. Arch Toxicol. 2017;91:1925-1939 pubmed publisher
    ..the activation of proinflammatory signaling, including JNK/c-jun, JAK2/STAT3, IRE1? and NF-?B and the expression of Fn14. Expression of proinflammatory factors and cytokines was also decreased, and kidney monocyte and lymphocyte influx ..
  82. Zhu C, Zhang L, Liu Z, Li C, Bai Y. TWEAK/Fn14 interaction induces proliferation and migration in human airway smooth muscle cells via activating the NF-?B pathway. J Cell Biochem. 2017;: pubmed publisher
    ..of the tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible molecule 14 (Fn14) axis on cell proliferation and migration in HASMCs...
  83. Hersh D, Peng S, Dancy J, Galisteo R, Eschbacher J, Castellani R, et al. Differential expression of the TWEAK receptor Fn14 in IDH1 wild-type and mutant gliomas. J Neurooncol. 2018;138:241-250 pubmed publisher
    The TNF receptor superfamily member Fn14 is overexpressed by many solid tumor types, including glioblastoma (GBM), the most common and lethal form of adult brain cancer...
  84. Roos C, Wicovsky A, Muller N, Salzmann S, Rosenthal T, Kalthoff H, et al. Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. J Immunol. 2010;185:1593-605 pubmed publisher
    ..Blockade of the Fn14 receptor inhibited NF-kappaB signaling irrespective of the TWEAK form used for stimulation, indicating that the ..
  85. Zhou H, Hittelman W, Yagita H, Cheung L, Martin S, Winkles J, et al. Antitumor activity of a humanized, bivalent immunotoxin targeting fn14-positive solid tumors. Cancer Res. 2013;73:4439-50 pubmed publisher
    The TNF-like weak inducer of apoptosis (TWEAK; TNFSF12) receptor Fn14 (TNFRSF12A) is expressed at low levels in normal tissues but frequently highly expressed in a wide range of tumor types such as lung, melanoma, and breast, and ..
  86. Xu T, Yang Y, Zhao L, Zhou D, Zhang Y. [Prediction Value of TWEAK/Fn14 in Crohn's Disease with Intestinal Fibrosis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2017;48:721-726 pubmed
    ..expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/ fibroblast growth factorinducible 14 (Fn14) in the serum and colon tissue of Crohn's disease (CD) and to elucidate whether the expression of TWEAK/Fn14 can be ..
  87. Chen X, Farrokhi V, Singh P, Ocaña M, Patel J, Lin L, et al. Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease. MAbs. 2017;:1-9 pubmed publisher
    Discovery of the upregulation of fibroblast growth factor-inducible-14 (Fn14) receptor following tissue injury has prompted investigation into biotherapeutic targeting of the Fn14 receptor for the treatment of conditions such as chronic ..
  88. Burkly L, Dohi T. The TWEAK/Fn14 pathway in tissue remodeling: for better or for worse. Adv Exp Med Biol. 2011;691:305-22 pubmed publisher
  89. Sun Y, Han Y, Wang X, Wang W, Wang X, Wen M, et al. Correlation of EGFR Del 19 with Fn14/JAK/STAT signaling molecules in non-small cell lung cancer. Oncol Rep. 2016;36:1030-40 pubmed publisher
    ..research has shown that p-EGFR (particularly mutated EGFR) may activate fibroblast growth factor-inducible 14 (Fn14) expression in non-small cell lung cancer (NSCLC), and the JAK/STAT signaling pathway may participate in this ..
  90. Wang T, Ma S, Qi X, Tang X, Cui D, Wang Z, et al. Knockdown of the differentially expressed gene TNFRSF12A inhibits hepatocellular carcinoma cell proliferation and migration in vitro. Mol Med Rep. 2017;15:1172-1178 pubmed publisher
    ..identified differences in gene expression, expression of tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) was markedly higher in HCC tissue than in adjacent tissue...
  91. Madrigal Matute J, Fernández Laso V, Sastre C, Llamas Granda P, Egido J, Martin Ventura J, et al. TWEAK/Fn14 interaction promotes oxidative stress through NADPH oxidase activation in macrophages. Cardiovasc Res. 2015;108:139-47 pubmed publisher
    ..TNF-like weak inducer of apoptosis (TWEAK, Tnfsf12) and the receptor, fibroblast growth factor-inducible 14 (Fn14), regulates vascular damage through different mechanisms, including inflammation...
  92. Meulendijks D, Lassen U, Siu L, Huitema A, Karanikas V, Mau Sorensen M, et al. Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors. Clin Cancer Res. 2016;22:858-67 pubmed publisher
    The TWEAK-Fn14 pathway represents a novel anticancer target that is being actively investigated. Understanding the relationship between pharmacokinetics of anti-TWEAK therapeutics and tumor pharmacodynamics is critical...