TNFRSF11A

Summary

Gene Symbol: TNFRSF11A
Description: TNF receptor superfamily member 11a
Alias: CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER, tumor necrosis factor receptor superfamily member 11A, Paget disease of bone 2, loss of heterozygosity, 18, chromosomal region 1, osteoclast differentiation factor receptor, receptor activator of NF-KB, receptor activator of nuclear factor-kappa B, tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Species: human
Products:     TNFRSF11A

Top Publications

  1. Collin Osdoby P. Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 2004;95:1046-57 pubmed
    ..One emerging area in vascular biology involves the RANKL/RANK/OPG system, molecules of the tumor necrosis factor-related family recently discovered to be critical regulators of ..
  2. Peng X, Guo W, Ren T, Lou Z, Lu X, Zhang S, et al. Differential expression of the RANKL/RANK/OPG system is associated with bone metastasis in human non-small cell lung cancer. PLoS ONE. 2013;8:e58361 pubmed publisher
    ..The RANKL/RANK/OPG system, which plays a pivotal role in bone remodeling by regulating osteoclast formation and activity, is of ..
  3. Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya Tsuji J, Matsumoto K, et al. Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol. 2002;22:992-1000 pubmed
    The receptor activator of NF-kappaB (RANK) and its ligand RANKL are key molecules for differentiation and activation of osteoclasts...
  4. Fiumara P, Snell V, Li Y, Mukhopadhyay A, Younes M, Gillenwater A, et al. Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines. Blood. 2001;98:2784-90 pubmed
    ..Previous studies reported that receptor activator of nuclear factor kappaB (NF-kappaB) (RANK), a member of the TNF receptor family, is expressed on DCs, and that RANK ligand (RANKL) enhances DC survival and ..
  5. Wada T, Nakashima T, Oliveira dos Santos A, Gasser J, Hara H, Schett G, et al. The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 2005;11:394-9 pubmed
    ..Receptor activator of NF-kappaB (RANK) and its ligand RANKL have been identified as essential factors involved in osteoclast development and bone ..
  6. Santini D, Perrone G, Roato I, Godio L, Pantano F, Grasso D, et al. Expression pattern of receptor activator of NF?B (RANK) in a series of primary solid tumors and related bone metastases. J Cell Physiol. 2011;226:780-4 pubmed publisher
    Receptor activator of NF?B ligand (RANKL), RANK, and osteoprotegerin (OPG) represent the key regulators of bone metabolism both in normal and pathological conditions, including bone metastases...
  7. Palenzuela L, Vives Bauza C, Fernandez Cadenas I, Meseguer A, Font N, Sarret E, et al. Familial expansile osteolysis in a large Spanish kindred resulting from an insertion mutation in the TNFRSF11A gene. J Med Genet. 2002;39:E67 pubmed
  8. Hsu Y, Niu T, Terwedow H, Xu X, Feng Y, Li Z, et al. Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet. 2006;118:568-77 pubmed
    In order to assess the contribution of polymorphisms in the RANKL (TNFSF11), RANK (TNFRSF11A) and OPG (TNFRSF11B) genes to variations in bone mineral density (BMD), a population-based cohort with 1,120 extreme low hip BMD cases or ..
  9. Choi J, Shin A, Park S, Chung H, Cho S, Shin C, et al. Genetic polymorphisms of OPG, RANK, and ESR1 and bone mineral density in Korean postmenopausal women. Calcif Tissue Int. 2005;77:152-9 pubmed
    To evaluate the effects of genetic polymorphisms of OPG, RANK, and ESR1, which regulate osteoclastogenesis, on bone mineral density (BMD), a cross-sectional study was conducted in 650 Korean postmenopausal women...

More Information

Publications74

  1. Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, et al. Central control of fever and female body temperature by RANKL/RANK. Nature. 2009;462:505-9 pubmed publisher
    ..ligand (TNFSF11, also known as RANKL, OPGL, TRANCE and ODF) and its tumour necrosis factor (TNF)-family receptor RANK are essential regulators of bone remodelling, lymph node organogenesis and formation of a lactating mammary gland...
  2. Galibert L, Tometsko M, Anderson D, Cosman D, Dougall W. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem. 1998;273:34120-7 pubmed
    Receptor activator of NF-kappaB (RANK) is a recently identified member of the tumor necrosis factor receptor superfamily and is expressed on activated T cells and dendritic cells...
  3. Arron J, Vologodskaia M, Wong B, Naramura M, Kim N, Gu H, et al. A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation. J Biol Chem. 2001;276:30011-7 pubmed
    ..We recently demonstrated that TRANCE activates Akt via a mechanism involving TRANCE receptor (TRANCE-R)/RANK, TRAF6, and c-Src...
  4. Wittrant Y, Lamoureux F, Mori K, Riet A, Kamijo A, Heymann D, et al. RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells. Int J Oncol. 2006;28:261-9 pubmed
    ..undifferentiated phenotype, expressing both osteoblastic and unexpected osteoclastic markers (TRAP, cathepsin K and RANK)...
  5. Hsu C, Lin T, Kuo C, Tsai C, Lin M, Hsu H, et al. Involvement of integrin up-regulation in RANKL/RANK pathway of chondrosarcomas migration. J Cell Biochem. 2010;111:138-47 pubmed publisher
    ..Receptor activator of nuclear factor-kappaB ligand (RANKL) and its receptor, RANK, play a key roles in osteoclastogenesis and tumor metastasis...
  6. Liu S, Shi W, Xiao H, Liang X, Deng C, Ye Z, et al. Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. PLoS ONE. 2012;7:e41331 pubmed publisher
    ..The ligand of receptor activator of NF-kappaB (RANKL) and receptor activator of NF-kappaB (RANK) are members of the TNF and receptor superfamilies...
  7. Paternoster L, Ohlsson C, Sayers A, Vandenput L, Lorentzon M, Evans D, et al. OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts. J Clin Endocrinol Metab. 2010;95:3940-8 pubmed publisher
    ..In the ALSPAC cohort, we found a significant association between RANK SNP (rs3018362) and BMDC but not any of the other pQCT bone measures...
  8. Armstrong A, Miller R, Jones J, Zhang J, Keller E, Dougall W. RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes. Prostate. 2008;68:92-104 pubmed
    ..b>RANK is essential for osteoclast differentiation, activation, and survival via its expression on osteoclasts and their ..
  9. Anderson D, Maraskovsky E, Billingsley W, Dougall W, Tometsko M, Roux E, et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 1997;390:175-9 pubmed
    ..Here we report the characterization of RANK (for receptor activator of NF-kappaB), a new member of the TNFR family derived from dendritic cells, and the ..
  10. Nakatsuka K, Nishizawa Y, Ralston S. Phenotypic characterization of early onset Paget's disease of bone caused by a 27-bp duplication in the TNFRSF11A gene. J Bone Miner Res. 2003;18:1381-5 pubmed
    Three different insertion mutations in the TNFRSF11A gene affecting the signal peptide of RANK have been described...
  11. Styrkarsdottir U, Halldorsson B, Gretarsdottir S, Gudbjartsson D, Walters G, Ingvarsson T, et al. New sequence variants associated with bone mineral density. Nat Genet. 2009;41:15-7 pubmed publisher
    ..These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21...
  12. Albagha O, Wani S, Visconti M, Alonso N, Goodman K, Brandi M, et al. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. Nat Genet. 2011;43:685-9 pubmed publisher
    ..We previously identified variants at the CSF1, OPTN and TNFRSF11A loci as risk factors for PDB by genome-wide association study...
  13. Tan W, Zhang W, Strasner A, Grivennikov S, Cheng J, Hoffman R, et al. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011;470:548-53 pubmed publisher
    ..tumours and the upregulation of two tumour-necrosis-factor family members: receptor activator of nuclear factor-?B (RANK) ligand (RANKL) and lymphotoxin. But the source of RANKL and its role in metastasis have not been established...
  14. Lu Y, Liu P, Recker R, Deng H, Dvornyk V. TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women. Menopause. 2010;17:1048-54 pubmed publisher
    ..The onsets of menarche and menopause have a strong genetic basis. We tested two genes, TNFRSF11A (RANK) and TNFSF11 (RANKL), for their association with age at menarche (AM) and age at natural menopause (ANM)...
  15. Estrada K, Styrkarsdottir U, Evangelou E, Hsu Y, Duncan E, Ntzani E, et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet. 2012;44:491-501 pubmed publisher
    ..Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways...
  16. Owen S, Ye L, Sanders A, Mason M, Jiang W. Expression profile of receptor activator of nuclear-?B (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) in breast cancer. Anticancer Res. 2013;33:199-206 pubmed
    ..Receptor activator of nuclear-?B (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are a group of important regulators for osteoclast differentiation ..
  17. Guerrini M, Sobacchi C, Cassani B, Abinun M, Kilic S, Pangrazio A, et al. Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am J Hum Genet. 2008;83:64-76 pubmed publisher
    ..RANKL and RANK (coded for by the TNFRSF11A gene) also play a role in the immune system, which raises the possibility that defects in this pathway might ..
  18. Albagha O, Visconti M, Alonso N, Langston A, Cundy T, Dargie R, et al. Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone. Nat Genet. 2010;42:520-4 pubmed publisher
    ..09 x 10(-13)) and with rs3018362 on 18q21 near the TNFRSF11A gene (P = 5.27 x 10(-13))...
  19. Whyte M, Hughes A. Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis. J Bone Miner Res. 2002;17:26-9 pubmed
    ..reported to have an identical 18-base pair tandem duplication (84dup18) in the signal peptide sequence of the TNFRSF11A gene that encodes receptor activator of nuclear factor-kappaB (RANK)...
  20. Kupas V, Weishaupt C, Siepmann D, Kaserer M, Eickelmann M, Metze D, et al. RANK is expressed in metastatic melanoma and highly upregulated on melanoma-initiating cells. J Invest Dermatol. 2011;131:944-55 pubmed publisher
    Melanoma accounts for ? 79% of skin cancer-related deaths, and the receptor activator of NF-?B (RANK)-receptor activator of NF-?B ligand (RANKL) pathway has been shown to be involved in the migration and metastasis of epithelial tumor ..
  21. Bonifaci N, Palafox M, Pellegrini P, Osorio A, Benitez J, Peterlongo P, et al. Evidence for a link between TNFRSF11A and risk of breast cancer. Breast Cancer Res Treat. 2011;129:947-54 pubmed publisher
    ..activator of nuclear factor-?B [Rank, encoded by the tumor necrosis factor receptor superfamily, member 11a (Tnfrsf11a) gene] is fundamental for mammary gland development in mice, regulating the expansion of stem and progenitor ..
  22. Palafox M, Ferrer I, Pellegrini P, Vila S, Hernández Ortega S, Urruticoechea A, et al. RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis. Cancer Res. 2012;72:2879-88 pubmed publisher
    Paracrine signaling through receptor activator of NF-?B (RANK) pathway mediates the expansion of mammary epithelia that occurs during pregnancy, and activation of RANK pathway promotes mammary tumorigenesis in mice...
  23. Roshandel D, Holliday K, Pye S, Boonen S, Borghs H, Vanderschueren D, et al. Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men. J Bone Miner Res. 2010;25:1830-8 pubmed publisher
    The aim of this study was to determine if single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG influence bone turnover and bone mineral density (BMD) in men. Pairwise tag SNPs (r(2) > or = 0...
  24. Huang C, Wei J, Hung P, Shiu L, Tsay M, Wong R, et al. Osteoprotegerin genetic polymorphisms and age of symptom onset in ankylosing spondylitis. Rheumatology (Oxford). 2011;50:359-65 pubmed publisher
    Osteoporosis is one of the recognized features of AS. It is known that RANK ligand (RANKL), which binds to RANK, can cause the activation of bone resorption...
  25. Li J, Sarosi I, Yan X, Morony S, Capparelli C, Tan H, et al. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A. 2000;97:1566-71 pubmed
    We have generated RANK (receptor activator of NF-kappaB) nullizygous mice to determine the molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK during bone resorption and remodeling processes...
  26. Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K, et al. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun. 1998;253:395-400 pubmed
    ..Nucleotide sequence analysis revealed that ODFR is identical to RANK, a recently identified member of the tumor necrosis factor receptor (TNFR) family, which is involved in the ..
  27. Darnay B, Ni J, Moore P, Aggarwal B. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem. 1999;274:7724-31 pubmed
    ..We have previously shown that the cytoplasmic domain of receptor activator of NF-kappaB (RANK) interacts with TRAF2, TRAF5, and TRAF6 and that its overexpression activates NF-kappaB and JNK pathways...
  28. Darnay B, Haridas V, Ni J, Moore P, Aggarwal B. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 1998;273:20551-5 pubmed
    ..The receptor activator of NF-kappaB (RANK), a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and ..
  29. Hughes A, Shearman A, Weber J, Barr R, Wallace R, Osterberg P, et al. Genetic linkage of familial expansile osteolysis to chromosome 18q. Hum Mol Genet. 1994;3:359-61 pubmed
    ..1-q22. Mapping a new locus for a gene involved in regulation of bone metabolism may also have implications in the study of Paget's disease of bone which is a common related bone dysplasia. ..
  30. Dougall W, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, et al. RANK is essential for osteoclast and lymph node development. Genes Dev. 1999;13:2412-24 pubmed
    The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated by generating RANK-deficient mice...
  31. Styrkarsdottir U, Halldorsson B, Gretarsdottir S, Gudbjartsson D, Walters G, Ingvarsson T, et al. Multiple genetic loci for bone mineral density and fractures. N Engl J Med. 2008;358:2355-65 pubmed publisher
    ..osteoporotic fractures, as were loci at 18q21, close to the receptor activator of the nuclear factor-kappaB gene (RANK), and loci at 2p16 and 11p11...
  32. Assmann G, Koenig J, Pfreundschuh M, Epplen J, Kekow J, Roemer K, et al. Genetic variations in genes encoding RANK, RANKL, and OPG in rheumatoid arthritis: a case-control study. J Rheumatol. 2010;37:900-4 pubmed publisher
    ..The receptor activator of nuclear factor-kappaB (RANK) and the osteoprotegerin (OPG) cascade system have been reported to be essential in osteoclastogenesis...
  33. Boyce B, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 2007;9 Suppl 1:S1 pubmed
    The discovery of the receptor activator of nuclear factor-kappaB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-based approach can identify ..
  34. Santini D, Schiavon G, Vincenzi B, Gaeta L, Pantano F, Russo A, et al. Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients. PLoS ONE. 2011;6:e19234 pubmed publisher
    Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor of RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation and activity...
  35. Cremer I, Dieu Nosjean M, Maréchal S, Dezutter Dambuyant C, Goddard S, Adams D, et al. Long-lived immature dendritic cells mediated by TRANCE-RANK interaction. Blood. 2002;100:3646-55 pubmed
    ..We have identified int-DCs that express both TRANCE (tumor necrosis factor-related activation-induced cytokine) and RANK (receptor activator of NF-kappaB) and have generated these cells from CD34(+) human progenitor cells using ..
  36. Pan R, Liu Y, Deng H, Dvornyk V. Association analyses suggest the effects of RANK and RANKL on age at menarche in Chinese women. Climacteric. 2012;15:75-81 pubmed publisher
    ..an analysis for association of single nucleotide polymorphisms (SNPs) and common haplotypes of two candidate genes, RANK (receptor activator of the NF-?B) and RANKL (receptor activator of the NF-?B ligand), with AAM in 825 unrelated ..
  37. Johnson Pais T, Singer F, Bone H, McMurray C, Hansen M, Leach R. Identification of a novel tandem duplication in exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysis. J Bone Miner Res. 2003;18:376-80 pubmed
    ..The TNFRSF11A gene encodes the receptor activator of nuclear factor-kappaB (RANK), which has been demonstrated to be essential ..
  38. Hughes A, Ralston S, Marken J, Bell C, MacPherson H, Wallace R, et al. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat Genet. 2000;24:45-8 pubmed
    ..The gene encoding receptor activator of nuclear factor-kappa B (RANK; ref. 5), TNFRSF11A, maps to this region. RANK is essential in osteoclast formation...
  39. Cannon J, Kraj B, Sloan G. Follicle-stimulating hormone promotes RANK expression on human monocytes. Cytokine. 2011;53:141-4 pubmed publisher
    ..concentrations spanning the physiological range, and then measuring the expression of receptor activator for NF-?B (RANK, a surface marker for osteoclasts) on CD14(+) cells by flow cytometry. In the absence of FSH, 3.3±0...
  40. Wong B, Besser D, Kim N, Arron J, Vologodskaia M, Hanafusa H, et al. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol Cell. 1999;4:1041-9 pubmed
    ..These results define a mechanism by which TRANCE activates Src family kinases and PKB and provide evidence of cross-talk between TRAF proteins and Src family kinases. ..
  41. Mazzolari E, Forino C, Razza A, Porta F, Villa A, Notarangelo L. A single-center experience in 20 patients with infantile malignant osteopetrosis. Am J Hematol. 2009;84:473-9 pubmed publisher
    ..9 months, and mean follow-up was 66.75 months. Mutations in TCIRG1, OSTM1, ClCN7, and TNFRSF11A genes were detected in nine, three, one, and one patients, respectively...
  42. Lopez J, Susarla S, Swanson E, Calotta N, Lifchez S. The Association of the H-Index and Academic Rank Among Full-Time Academic Hand Surgeons Affiliated With Fellowship Programs. J Hand Surg Am. 2015;40:1434-41 pubmed publisher
    To evaluate the association between the Hirsch index (a measure of publications and citations) and academic rank among hand surgeons...
  43. Appannah G, Pot G, Huang R, Oddy W, Beilin L, Mori T, et al. Identification of a dietary pattern associated with greater cardiometabolic risk in adolescence. Nutr Metab Cardiovasc Dis. 2015;25:643-50 pubmed publisher
    ..data were measured and z-scores for an 'energy dense, high fat and low fibre' DP were estimated using reduced rank regression (RRR)...
  44. Agarwal R, Rajanbabu A, Nair I, Satish C, Jose G, Unikrishnan U. Endometrial stromal sarcoma-A retropsective analysis of factors affecting recurrence. Eur J Obstet Gynecol Reprod Biol. 2017;216:92-97 pubmed publisher
    ..Disease free and overall survivals were analysed using Kaplan-Meier method and compared using log rank test. Out of 38 patients included in analysis 28 (73.7%) had low grade ESS (LGESS) and 10 (26...
  45. Barney C, Walston S, Zamora P, Healy E, Nolan N, Diavolitsis V, et al. Clinical outcomes and prognostic factors in cisplatin versus cetuximab chemoradiation for locally advanced p16 positive oropharyngeal carcinoma. Oral Oncol. 2018;79:9-14 pubmed publisher
    ..Log-rank/Kaplan-Meier and Cox Regression methods were used to compare groups...
  46. Weberding N, Saladino R, Minnigh M, Oberly P, Tudorascu D, Poloyac S, et al. Adenosine Administration With a Stopcock Technique Delivers Lower-Than-Intended Drug Doses. Ann Emerg Med. 2018;71:220-224 pubmed publisher
    ..08 to 0.09 mg/kg), and 0.1 mg/kg (IQR 0.09 to 0.1 mg/kg) for weights 2 to 5, 6 to 9, and 10 to 25 kg, respectively (rank difference=100; P<.05 for 2 to 5 kg versus 10 to 25 kg). Similar results were obtained with spectrophotometry...
  47. Mave V, Nimkar S, Prasad H, Kadam D, Meshram S, Lokhande R, et al. Tuberculosis screening among persons with diabetes mellitus in Pune, India. BMC Infect Dis. 2017;17:388 pubmed publisher
    ..The x 2 test or Wilcoxon rank-sum test was used to ascertain significant associations between categorical and continuous variables, respectively...
  48. Yang Y, Zhang C, Lu J. Local Observability Analysis of Star Sensor Installation Errors in a SINS/CNS Integration System for Near-Earth Flight Vehicles. Sensors (Basel). 2017;17: pubmed publisher
    ..Meanwhile, a local observability analysis is performed on the rank of observability matrix obtained via linearization observation equation, and the observable conditions are ..
  49. Wang T, Zhao Y, Peng L, Chen N, Chen W, Lv Y, et al. Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway. Gut. 2017;66:1900-1911 pubmed publisher
    ..Kaplan-Meier plots for overall survival were performed using the log-rank test...
  50. Amelot A, Smajda S, Terrier L, Redjem H, Simonneau A, Bekaert O, et al. Posterior Fossa Craniectomy with Endovascular Therapy of Giant Fusiform Basilar Artery Aneurysms: A New Approach to Consider?. World Neurosurg. 2017;98:104-112 pubmed publisher
    ..7 months vs. 3.058 months for men; log-rank test P = 0.011)...
  51. Dombernowsky T, Kristensen M, Rysgaard S, Gluud L, Novovic S. Risk factors for and impact of respiratory failure on mortality in the early phase of acute pancreatitis. Pancreatology. 2016;16:756-60 pubmed publisher
    ..07)) and smoking (OR 2.67; CI 95% (1.21-5.86)). Thirteen patients died in hospital. The Kaplan-Meier curves and log-rank tests showed that patients with respiratory failure had increased in-hospital mortality as did patients with ..
  52. Jeong J, Chun Y, Park K. Epidemiologic Aspects of Medical Retirement from the Republic of Korea Army due to Visual Impairment. J Korean Med Sci. 2016;31:623-9 pubmed publisher
    ..The patients were grouped by the presence of trauma, and each group was subdivided by military rank. We analyzed demographic and ophthalmic data, including the etiology of ophthalmologic disease...
  53. Chaddad A, Tanougast C. Extracted magnetic resonance texture features discriminate between phenotypes and are associated with overall survival in glioblastoma multiforme patients. Med Biol Eng Comput. 2016;54:1707-1718 pubmed
    ..of correlation, and inverse difference were statistically significant in the prediction of survival, with log-rank p values of 0.001, 0.001, and 0.008, respectively...
  54. von Pfeil D, Sung J, Barry J, Hayashi K, Edwards M. Effect of doxycycline on contralateral canine cranial cruciate ligament rupture. A prospective randomized clinical trial in 69 dogs. Vet Comp Orthop Traumatol. 2015;28:371-8 pubmed publisher
    ..Statistics included chi-squared test, logistic regression, Kaplan-Meier survival analysis, log rank test, survival curves, and frailty model (p <0.05)...
  55. Sui X, Jiang W, Chen H, Yang F, Wang J, Wang Q. Validation of the Stage Groupings in the Eighth Edition of the TNM Classification for Lung Cancer. J Thorac Oncol. 2017;12:1679-1686 pubmed publisher
    ..Survival was compared between adjacent stage groupings by using a log-rank test and a Cox regression model...
  56. Li X, Wang X, Xiao G. A comparative study of rank aggregation methods for partial and top ranked lists in genomic applications. Brief Bioinform. 2017;: pubmed publisher
    b>Rank aggregation (RA), the process of combining multiple ranked lists into a single ranking, has played an important role in integrating information from individual genomic studies that address the same biological question...
  57. Ogawa A, Miyaji K, Matsubara H. Efficacy and safety of long-term imatinib therapy for patients with pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. Respir Med. 2017;131:215-219 pubmed publisher
    ..9-1878.5 days), significantly longer than those without imatinib treatment (713.0 ± 258.1 days, log-rank test, P = 0.04). Imatinib improved exercise capacity, hemodynamics and survival in patients with PVOD/PCH...
  58. Ge L, Li N, Liu M, Xu N, Wang M, Wu L. Copy number variations of neurotrophic tyrosine receptor kinase 3 (NTRK3) may predict prognosis of ovarian cancer. Medicine (Baltimore). 2017;96:e7621 pubmed publisher
    ..Spearman's rank correlation analysis and ? test were used to evaluate the accuracy of CNVs of NTRK3 which predicted platinum-..
  59. Noleto Filho E, Dos Santos Gauy A, Pennino M, Gonçalves de Freitas E. Bayesian analysis improves experimental studies about temporal patterning of aggression in fish. Behav Processes. 2017;145:18-26 pubmed publisher
    ..as well that using a small sample size could be more evident within the overlapping days, that includes the social rank stability...
  60. Offermann A, Hohensteiner S, Kuempers C, Ribbat Idel J, Schneider F, Becker F, et al. Prognostic Value of the New Prostate Cancer International Society of Urological Pathology Grade Groups. Front Med (Lausanne). 2017;4:157 pubmed publisher
    ..based on both former Gleason Grading and ISUP Grade Groups, and was statistically significant using the log-rank test (p?<?0.001)...
  61. Weizman L, Miller K, Eldar Y, Chiew M. PEAR: PEriodic And fixed Rank separation for fast fMRI. Med Phys. 2017;44:6166-6182 pubmed publisher
    ..We present an fMRI reconstruction approach based on modeling the fMRI signal as a sum of periodic and fixed rank components, for improved reconstruction from undersampled measurements.
  62. Wang S, Yue B, Liang X, Jiao L. How Does the Low-Rank Matrix Decomposition Help Internal and External Learnings for Super-Resolution. IEEE Trans Image Process. 2018;27:1086-1099 pubmed publisher
    ..These inspire us to propose a low-rank solution which effectively integrates two learning methods and then achieves a superior result...
  63. Bratt C, Sidanius J, Sheehy Skeffington J. Shaping the Development of Prejudice: Latent Growth Modeling of the Influence of Social Dominance Orientation on Outgroup Affect in Youth. Pers Soc Psychol Bull. 2016;42:1617-1634 pubmed
    ..Overall, SDO exhibits high temporal rank-order stability and predicts changes in outgroup affect...
  64. Zhao J, Lv Y, Zhou Z, Cao F. A novel deep learning algorithm for incomplete face recognition: Low-rank-recovery network. Neural Netw. 2017;94:115-124 pubmed publisher
    ..In this paper, a novel convolution neural network frame, named a low-rank-recovery network (LRRNet), is proposed to conquer the difficulty effectively inspired by matrix completion and deep ..
  65. Lee C, Huang C, Xu G, Luo X. Semiparametric regression analysis for alternating recurrent event data. Stat Med. 2017;: pubmed publisher
    ..bias commonly confronted in serial event gap time data but also is more computationally tractable than the existing rank-based methods...