Gene Symbol: TNFRSF10D
Description: TNF receptor superfamily member 10d
Alias: CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD, tumor necrosis factor receptor superfamily member 10D, TNF receptor-related receptor for TRAIL, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL receptor with a truncated death domain, decoy receptor 2, tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Species: human
Products:     TNFRSF10D

Top Publications

  1. Yang Q, Kiernan C, Tian Y, Salwen H, Chlenski A, Brumback B, et al. Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome. Clin Cancer Res. 2007;13:3191-7 pubmed
    ..In primary neuroblastoma tumors, high-risk disease and poor outcome were associated with methylation of DCR2, CASP8, and HIN-1 individually...
  2. Venza M, Visalli M, Catalano T, Fortunato C, Oteri R, Teti D, et al. Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma. Biochem Biophys Res Commun. 2013;441:743-50 pubmed publisher
    ..No correlation between methylation status of DR4 and DR5 and gene expression was found. DcR1 and DcR2 were hypermethylated with very high frequency in both cutaneous and uveal melanoma...
  3. Degli Esposti M, Dougall W, Smolak P, Waugh J, Smith C, Goodwin R. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity. 1997;7:813-20 pubmed
    ..Like TRAIL-R1 and TRAIL-R2, this receptor shows widespread tissue expression. The human TRAIL-R4 gene has been mapped to chromosome 8p22-21, clustered with three other TRAIL receptors. ..
  4. Yagyu S, Gotoh T, Iehara T, Miyachi M, Katsumi Y, Tsubai Shimizu S, et al. Circulating methylated-DCR2 gene in serum as an indicator of prognosis and therapeutic efficacy in patients with MYCN nonamplified neuroblastoma. Clin Cancer Res. 2008;14:7011-9 pubmed publisher
    ..Aberrant hypermethylation of the DCR2 promoter has recently been associated with rapidly progressing neuroblastoma...
  5. Merino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O. Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol. 2006;26:7046-55 pubmed
    ..TRAIL can also bind decoy receptor 1 (DcR1) (TRAIL-R3) and DcR2 (TRAIL-R4) that fail to induce apoptosis since they lack and have a truncated cytoplasmic death domain, ..
  6. Hasegawa H, Yamada Y, Harasawa H, Tsuji T, Murata K, Sugahara K, et al. Restricted expression of tumor necrosis factor-related apoptosis-inducing ligand receptor 4 in human peripheral blood lymphocytes. Cell Immunol. 2004;231:1-7 pubmed
    ..TRAIL-R1 is distinctively expressed on B-lymphocytes, TRAIL-R2 on monocytes, TRAIL-R3 on neutrophils and most impressively, CD8+ lymphocytes and NKT lymphocytes but not CD4+ lymphocytes express TRAIL-R4. ..
  7. Shivapurkar N, Toyooka S, Toyooka K, Reddy J, Miyajima K, Suzuki M, et al. Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types. Int J Cancer. 2004;109:786-92 pubmed
    ..receptors, 2 proapoptotic (DR4 and DR5), and 2 potentially antiapoptotic receptors lacking death domains (DcR1 and DcR2)...
  8. Bonazzi V, Nancarrow D, Stark M, Moser R, Boyle G, Aoude L, et al. Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma. PLoS ONE. 2011;6:e26121 pubmed publisher
    ..We found transcript levels of UCHL1, COL1A2, THBS1 and TNFRSF10D were inversely correlated with promoter methylation...
  9. Sanlioglu A, Dirice E, Elpek O, Korcum A, Ozdogan M, Suleymanlar I, et al. High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients. Pancreas. 2009;38:154-60 pubmed publisher

More Information


  1. Sanlioglu A, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Cancer. 2005;5:54 pubmed
    ..In addition, a DcR2 siRNA approach and a complementary gene therapy modality involving IKK inhibition (AdIKKbetaKA) were also tested to ..
  2. Zhao X, Liu L, Li R, Wei X, Luan W, Liu P, et al. Hypoxia-Inducible Factor 1-α (HIF-1α) Induces Apoptosis of Human Uterosacral Ligament Fibroblasts Through the Death Receptor and Mitochondrial Pathways. Med Sci Monit. 2018;24:8722-8733 pubmed publisher
    ..HIF-1α treatment downregulated the expression of cellular FLICE inhibitory protein (c-FLIP), decoy receptor 2 (DcR2), and the ratio of Bcl-2 to Bax, and upregulated the expression tumor necrosis factor related apoptosis-..
  3. Lambrechts L, Quillery E, Noël V, Richardson J, Jarman R, Scott T, et al. Specificity of resistance to dengue virus isolates is associated with genotypes of the mosquito antiviral gene Dicer-2. Proc Biol Sci. 2013;280:20122437 pubmed publisher
    ..Dicer-2 (dcr2) encodes a key protein upstream of the RNA interference (RNAi) pathway, a major antiviral component of innate ..
  4. Meki I, Kariithi H, Parker A, Vreysen M, Ros V, Vlak J, et al. RNA interference-based antiviral immune response against the salivary gland hypertrophy virus in Glossina pallidipes. BMC Microbiol. 2018;18:170 pubmed publisher
    ..replication was accompanied by significant upregulation of the expression of three RNAi key genes; AGO1, AGO2 and DCR2, and a moderate increase in the expression of Drosha post injection compared to the PBS-injected controls...
  5. Han N, Zhou Q, Huang Q, Liu K. Carnosic acid cooperates with tamoxifen to induce apoptosis associated with Caspase-3 activation in breast cancer cells in vitro and in vivo. Biomed Pharmacother. 2017;89:827-837 pubmed publisher
    ..The elevation of decoy receptor 1 and 2 (DcR1 and DcR2) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) were enhanced for carnosic acid and tamoxifen ..
  6. Brunetti G, Di Benedetto A, Posa F, Colaianni G, Faienza M, Ballini A, et al. High expression of TRAIL by osteoblastic differentiated dental pulp stem cells affects myeloma cell viability. Oncol Rep. 2018;39:2031-2039 pubmed publisher
    ..trend of TRAIL receptors underwent changes during the osteoblastic differentiation of DPSCs exhibiting low DcR2 and high DR5 levels in the undifferentiated DPSCs and an opposite scenario was presented in the differentiated ..
  7. Anees M, Horak P, Schiefer A, Vanhara P, El Gazzar A, Perco P, et al. The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-κB. Leuk Lymphoma. 2015;56:1440-9 pubmed publisher
    ..5%), gain of decoy receptors (3.1%) or both (59.4%). Decoy receptor 2 (DcR2) was highly expressed in patients with normal cytogenetic status as compared to those with cytogenetic ..
  8. Liu P, Chang D, Lo Y, Hsi Y, Lin C, Chuang Y, et al. Osthole induces human nasopharyngeal cancer cells apoptosis through Fas-Fas ligand and mitochondrial pathway. Environ Toxicol. 2018;33:446-453 pubmed publisher
    ..Osthole treatment also increased the expression of Fas, FADD, TNF-R1, TNF-R2, DcR2, RIP, and DR5...
  9. Yang J, Leblanc F, Dighe S, Hamele C, Olson T, Feith D, et al. TRAIL mediates and sustains constitutive NF-?B activation in LGL leukemia. Blood. 2018;: pubmed publisher
    ..cells, but can also activate NF-?B through interaction with TRAIL receptors 1, 2 and 4 (also known as DR4, DR5 and DcR2 respectively). The role of TRAIL has not been studied in LGL leukemia...
  10. White K, Humphrey D, Hirth F. The dopaminergic system in the aging brain of Drosophila. Front Neurosci. 2010;4:205 pubmed publisher
    ..Analysis of TH > Dcr2, mCD8::GFP revealed a specific effect of Dcr2 expression on walking activity but not on exploratory or centrophobic ..
  11. Lee M, Kim D, Eom J, Ko Y, Sung K, Koo H, et al. RAD001 (everolimus) enhances TRAIL cytotoxicity in human leukemic Jurkat T cells by upregulating DR5. Biochem Biophys Res Commun. 2015;463:894-9 pubmed publisher
    ..22%, but not other TRAIL-Rs such as DR4 (TRAIL-R1), decoy receptor (DcR) 1 (TRAIL-R3), and DcR2 (TRAIL-R4)...
  12. Karamipour N, Fathipour Y, Talebi A, Asgari S, Mehrabadi M. Small interfering RNA pathway contributes to antiviral immunity in Spodoptera frugiperda (Sf9) cells following Autographa californica multiple nucleopolyhedrovirus infection. Insect Biochem Mol Biol. 2018;101:24-31 pubmed publisher
    ..Given that, here we explored the roles of Dicer-2 (Dcr2) and Argonaute 2 (Ago2) genes, key factors in the siRNA pathway in response to AcMNPV infection in Spodoptera ..
  13. Werner T, Nolten I, Dizdar L, Riemer J, Schütte S, Verde P, et al. IAPs cause resistance to TRAIL-dependent apoptosis in follicular thyroid cancer. Endocr Relat Cancer. 2018;25:295-308 pubmed publisher
    ..TRAIL-R2/DR5 as well as TRAIL-R3/DcR1 and TRAIL-R4/DcR2 were significantly higher expressed in advanced tumour stages...
  14. Sundaram K, Sambandam Y, Balasubramanian S, Pillai B, Voelkel Johnson C, Ries W, et al. STAT-6 mediates TRAIL induced RANK ligand expression in stromal/preosteoblast cells. Bone. 2015;71:137-44 pubmed publisher
    ..Herein, we show that TRAIL increases DR5 and DcR1 receptors but no change in the levels of DR4 and DcR2 expression in human bone marrow derived stromal/preosteoblast (SAKA-T) cell line...
  15. Todorova T, Bock F, Chang P. PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript. Nat Commun. 2014;5:5362 pubmed publisher
    ..Among the most upregulated transcripts is TRAILR4 that encodes a decoy receptor for TRAIL-a pro-apoptotic cytokine that is a promising target for the therapeutic ..
  16. Todorova T, Bock F, Chang P. Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer. Trends Mol Med. 2015;21:373-84 pubmed publisher
    ..the prosurvival cytokine receptor tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor 4 (TRAILR4) suggests that it can be protective against malignant transformation and cancer development...
  17. Chen J, Chen K, Wang L, Zhang W, Feng L, Dai H, et al. High-dose HOOK effect in urinary DcR2 assay in patients with chronic kidney disease. Clin Biochem. 2018;58:32-36 pubmed publisher
    Urinary DcR2 (uDcR2) is a biomarker for the early detection the tubulointerstitial injury (TII) in patients with chronic kidney disease (CKD), but the high-dose hook effect may lead to falsely low or even negative results when using an ..
  18. Li Z, Heng J, Yan J, Guo X, Tang L, Chen M, et al. Integrated analysis of gene expression and methylation profiles of 48 candidate genes in breast cancer patients. Breast Cancer Res Treat. 2016;160:371-383 pubmed
    ..A total of 9 genes (CCND2, EGFR, GSTP1, PGR, PTGS2, RECK, SOX17, TNFRSF10D, and WIF1) showed significant negative correlation between methylation and gene expression, which were validated ..
  19. Zheng X, Jiang P, Wu H, Shao X, Hu D, Jiang L, et al. [Associations of the decoy receptor and osteoprotegerin gene polymorphisms with ulcerative colitis in Chinese patients]. Zhonghua Nei Ke Za Zhi. 2014;53:521-6 pubmed
    To investigate the correlation between decoy receptor (DcR)1, DcR2 and osteoprotegerin (OPG) gene polymorphisms with the susceptibility to ulcerative colitis (UC) in Chinese population...
  20. Verim A, Turan S, Farooqi A, Kahraman O, Tepe Karaca C, Yildiz Y, et al. Association between laryngeal squamous cell carcinoma and polymorphisms in tumor necrosis factor related apoptosis induce ligand (TRAIL), TRAIL receptor and sTRAIL levels. Asian Pac J Cancer Prev. 2014;15:10697-703 pubmed
    ..Tumor necrosis factor related apoptosis induce ligand (TRAIL) and TRAIL-receptors (DR4, DR5, DcR1, DcR2) are known as important members of TRAIL-mediated biochemical signaling pathway...
  21. Woo J, Kang J, Jang Y, Ro S, Cho J, Kim H, et al. Evaluation of preventive and therapeutic activity of novel non-steroidal anti-inflammatory drug, CG100649, in colon cancer: Increased expression of TNF-related apoptosis-inducing ligand receptors enhance the apoptotic response to combination treatmen. Oncol Rep. 2015;33:1947-55 pubmed publisher
    ..apoptosis-inducing ligand (TRAIL) receptors (DR4 and DR5) but decreased the expression of decoy receptors (DcR1 and DcR2) in colon cancer cells...
  22. Fu B, Yang J, Chen J, Lin L, Chen K, Zhang W, et al. Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells. Front Med. 2019;13:267-276 pubmed publisher
    ..and cyclin D1, increased senescence-associated β-galactosidase activity, and elevated expression of membrane decoy receptor 2. SKI treatment potently prevented these changes in a dose-independent manner...
  23. Erkul E, Kucukodaci Z, Pinar D, Gungor A, Alparslan Babayigit M, Kurt O, et al. TRAIL and TRAIL receptors in patients with laryngeal cancer. Head Neck. 2016;38 Suppl 1:E535-41 pubmed publisher
    ..The H-score of decoy-R2 (DcR2) staining were increased significantly in tumor tissue (p = .04)...
  24. Kryvdiuk I, Minchenko D, Hlushchak N, Ratushna O, Karbovskyi L, Minchenko O. INHIBITION OF IRE1 MODIFIES EFFECT OF GLUCOSE DEPRIVATION ON THE EXPRESSION OF TNF?-RELATED GENES IN U87 GLIOMA CELLS. Ukr Biochem J. 2015;87:36-51 pubmed
    ..that glucose deprivation condition leads to down-regulation of the expression of TNFRSF11B, TNFRSF1A, TNFRSF10D/TRAILR4, and LITAF genes and up-regulation of TNFRSF10B/TRAILR2/DR5 gene at the mRNA level in control glioma ..
  25. Ouyang W, Zhang S, Yang B, Yang C, Zhang J, Zhou F, et al. β-catenin is regulated by USP9x and mediates resistance to TRAIL-induced apoptosis in breast cancer. Oncol Rep. 2016;35:717-24 pubmed publisher
    ..Luciferase assay was used to examine activity of the DcR1/DcR2/OPG reporter...
  26. Byström S, Eklund M, Hong M, Fredolini C, Eriksson M, Czene K, et al. Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density. Breast Cancer Res. 2018;20:14 pubmed publisher
    ..For eleven of these proteins evidence for gene expression in breast tissue existed. Among these, ABCC11, TNFRSF10D, F11R and ERRF were positively associated with AD, and SHC1, CFLAR, ACOX2, ITGB6, RASSF1, FANCD2 and IRX5 were ..
  27. Marmary Y, Adar R, Gaska S, Wygoda A, Maly A, Cohen J, et al. Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation. Cancer Res. 2016;76:1170-80 pubmed publisher
    ..damage response (γH2AX and 53BP1) and the expression of senescence-associated markers (SA-βgal, p19ARF, and DcR2) and secretory phenotype (SASP) factors (PAI-1 and IL6)...
  28. Gasparian M, Bychkov M, Yagolovich A, Dolgikh D, Kirpichnikov M. Mutations Enhancing Selectivity of Antitumor Cytokine TRAIL to DR5 Receptor Increase Its Cytotoxicity against Tumor Cells. Biochemistry (Mosc). 2015;80:1080-91 pubmed publisher
    ..The resistance is partially related to interaction of TRAIL with the decoy receptors DcR1 and DcR2, which do not trigger the apoptotic signal and inhibit signaling of death receptors...
  29. Rudolf Oliveira R, Auat M, Cardoso C, Santos Pirath I, Lange B, Pires Silva J, et al. Determination of normal expression patterns of CD86, CD210a, CD261, CD262, CD264, CD358, and CD361 in peripheral blood and bone marrow cells by flow cytometry. Immunol Lett. 2018;194:44-55 pubmed publisher
    ..the objective of this study was to determine the normal patterns of cell expression of CD86, CD210a, CD261, CD262, CD264, CD358, and CD361 in peripheral blood (PB) and bone marrow (BM) samples by flow cytometry...
  30. Yang Z, Ma J. Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochem Biophys Res Commun. 2018;497:1177-1183 pubmed publisher
    ..apoptotic response by enhancing Caspases cleavage, due to elevation of decoy receptor 1 and 2 (DcR1 and DcR2) dependent on p53...
  31. Harrington A, McKain M, Michalski D, Bauer K, Daugherty J, Steiniger M. Drosophila melanogaster retrotransposon and inverted repeat-derived endogenous siRNAs are differentially processed in distinct cellular locations. BMC Genomics. 2017;18:304 pubmed publisher
    ..We have identified a nucleus-specific interaction between the essential esiRNA cleavage enzyme Dicer2 (Dcr2) and Symplekin, a component of the core cleavage complex (CCC) required for 3' end processing of all eukaryotic ..
  32. Varjak M, Maringer K, Watson M, Sreenu V, Fredericks A, Pondeville E, et al. Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses. mSphere. 2017;2: pubmed publisher
    ..Here, we show that Piwi4 associates with members of the antiviral exogenous siRNA pathway (Ago2 and Dcr2), as well as with proteins of the piRNA pathway (Ago3, Piwi5, and Piwi6) in an Aedes aegypti-derived cell ..
  33. Chen K, Dai H, Yuan J, Chen J, Lin L, Zhang W, et al. Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy. Cell Death Dis. 2018;9:105 pubmed publisher
    ..In vitro, the expression of senescence markers P16, P21, DcR2, SA-β-gal, SAHF, and insufficient mitophagic degradation marker (mitochondrial P62) in mouse RTECs increased after ..
  34. Harith H, Di Bartolo B, Cartland S, Genner S, Kavurma M. Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand. J Diabetes. 2016;8:568-78 pubmed publisher
    ..but not glucose) was able to promote VSMC proliferation over time, associated with increased decoy receptor-2 (DcR2) expression...
  35. Chou Y, Yen C, Chen W, Lin Y, Wen Y, Ke W, et al. Cytotoxic mechanism of PLK1 inhibitor GSK461364 against osteosarcoma: Mitotic arrest, apoptosis, cellular senescence, and synergistic effect with paclitaxel. Int J Oncol. 2016;48:1187-94 pubmed publisher OS cell lines, as indicated by an increased senescence-associated β-galactosidase activity and enhanced DcR2 and interleukin-1α expression...
  36. Chen J, Chen K, Fu B, Zhang W, Dai H, Lin L, et al. Isolation and identification of senescent renal tubular epithelial cells using immunomagnetic beads based on DcR2. Exp Gerontol. 2017;95:116-127 pubmed publisher
    ..b>Decoy receptor 2 (DcR2) is a transmembrane receptor of the tumor necrosis factor superfamily, which is specifically expressed ..
  37. Xu Y, Li J, Li Q, Feng Y, Pan F. Betulinic acid promotes TRAIL function on liver cancer progression inhibition through p53/Caspase-3 signaling activation. Biomed Pharmacother. 2017;88:349-358 pubmed publisher
    ..apoptotic response by enhancing Caspases cleavage, due to elevation of decoy receptor 1 and 2 (DcR1 and DcR2) dependent on p53...
  38. Ratzinger G, Mitteregger S, Wolf B, Berger R, Zelger B, Weinlich G, et al. Association of TNFRSF10D DNA-methylation with the survival of melanoma patients. Int J Mol Sci. 2014;15:11984-95 pubmed publisher
    ..First, we identified the TNFRSF10D DNA-methylation status (TNFRSF10D methylated vs. unmethylated) as a prognostic marker for overall (p = 0...
  39. Krieg A, Schulte Am Esch J, Ramp U, Hosch S, Knoefel W, Gabbert H, et al. TRAIL-R4-beta: a new splice variant of TRAIL-receptor 4 lacking the cysteine rich domain 1. Biochem Biophys Res Commun. 2006;349:115-21 pubmed
    ..In conclusion, alternative splicing might be involved in functional fine-tuning of TRAIL-induced programmed cell death. ..
  40. Chen J, Zhang W, Chen K, Lin L, Dai H, Li K, et al. Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy. Am J Physiol Renal Physiol. 2017;313:F273-F281 pubmed publisher
    ..This study is to investigate whether urinary decoy receptor 2 (uDcR2) could serve as a novel noninvasive biomarker for assessing TII in DN...
  41. Riccioni R, Pasquini L, Mariani G, Saulle E, Rossini A, Diverio D, et al. TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL. Haematologica. 2005;90:612-24 pubmed
    ..Finally, APL blasts express membrane-bound TRAIL that could confer an immunologic privilege to these cells. ..
  42. Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, et al. Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A. 2005;102:18099-104 pubmed
    ..We propose that TR4 is a "regulatory" rather than "decoy" receptor that inhibits apoptosis signaling by TRAIL through this previously uncharacterized ligand-independent mechanism. ..
  43. Zhang Z, Rosen D, Yao J, Huang J, Liu J. Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression. Mod Pathol. 2006;19:1339-43 pubmed
    ..which are known to regulate G1 cell cycle arrest, and the tumor necrosis factor receptor superfamily member decoy receptor 2 (DCR2), have been recently identified as senescence markers...
  44. Madsen S, Russell K, Tucker H, Glowacki J, Bunnell B, O Connor K. Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells. Stem Cell Res Ther. 2017;8:201 pubmed publisher
    ..This study evaluates decoy TRAIL receptor CD264 as potentially the first surface marker to detect cellular aging in heterogeneous MSC cultures...
  45. Kotelkin A, Prikhod ko E, Cohen J, Collins P, Bukreyev A. Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand. J Virol. 2003;77:9156-72 pubmed
  46. Chen B, Ma B, Yang S, Xing X, Gu R, Hu Y. DR5 and DcR2 are expressed in human lumbar intervertebral discs. Spine (Phila Pa 1976). 2009;34:E677-81 pubmed publisher
    To conform the 3 media way of the apoptosis for the degenerative lumbar disc with DR5 (TRAIL-R2) and DcR2 (TRAIL-R4), as one of the tumor necrosis factors family...
  47. Cho S, Kim J, Ryu H, Kim J, Kim H, Park J, et al. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. Hum Immunol. 2004;65:710-8 pubmed
    ..90, p < 0.001). The validated SNPs in the TNF-TNFR superfamily would be valuable for association studies with several immune-mediated human diseases. ..
  48. Lum J, Schnepple D, Badley A. Acquired T-cell sensitivity to TRAIL mediated killing during HIV infection is regulated by CXCR4-gp120 interactions. AIDS. 2005;19:1125-33 pubmed
    ..These results indicate that chemokine receptor interactions regulate TRAIL receptor expression and provide an explanation for the acquired T cell sensitivity to TRAIL mediated killing death during HIV infection. ..
  49. Shlyakhtina Y, Pavet V, Gronemeyer H. Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells. Cell Death Dis. 2017;8:e3025 pubmed publisher
    ..Here we demonstrate that, in the context of DR4-DR5-DcR2 hetero-oligomeric complexes, a single death receptor (DR5) suffices to assemble composite plasma membrane-proximal ..
  50. Daigle I, Simon H. Alternative functions for TRAIL receptors in eosinophils and neutrophils. Swiss Med Wkly. 2001;131:231-7 pubmed
    ..Alternatively, TRAIL may limit cytokine-mediated antiapoptosis under certain inflammatory conditions. ..
  51. Kimberley F, Screaton G. Following a TRAIL: update on a ligand and its five receptors. Cell Res. 2004;14:359-72 pubmed
    ..This review takes a comprehensive look at the story of this enigmatic ligand, addressing its remaining potential as a therapeutic and providing an overview of the TRAIL receptors themselves. ..
  52. Phillips T, Ni J, Pan G, Ruben S, Wei Y, Pace J, et al. TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege. J Immunol. 1999;162:6053-9 pubmed
    ..Northern blotting demonstrated mRNAs encoding TRAIL as well as the four TRAIL receptors (DR4, DR5, DcR1/TRID, DcR2/TRUNDD) in human placentas...
  53. Matysiak M, Jurewicz A, Jaskolski D, Selmaj K. TRAIL induces death of human oligodendrocytes isolated from adult brain. Brain. 2002;125:2469-80 pubmed
    ..This result may implicate TRAIL as an effector-immune molecule in selective ahOL demise in inflammatory/demyelinating conditions. ..
  54. Pan G, Ni J, Yu G, Wei Y, Dixit V. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett. 1998;424:41-5 pubmed
    ..Herein, we report the identification of another member of the TRAIL receptor family, TRUNDD (TRAIL receptor with a truncated death domain). The TRUNDD transcript was detected in multiple human tissues...
  55. Hornstein M, Hoffmann M, Alexa A, Yamanaka M, Muller M, Jung V, et al. Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer. Cancer Genomics Proteomics. 2008;5:123-36 pubmed
    ..for two protein phosphatase subunit genes (PPP2CB, PPP3CC) and two TRAIL decoy receptors (TNFRSF10C/DcR1, TNFRSF10D/DcR2), but not for the three established candidates nor for TRAIL death receptor genes...
  56. McLaren P, Gawanbacht A, Pyndiah N, Krapp C, Hotter D, Kluge S, et al. Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. Retrovirology. 2015;12:41 pubmed publisher
    ..Five factors (APOL1, APOL6, CD164, TNFRSF10A, TNFRSF10D) suppressed infectious HIV-1 production in transfected 293T cells by >90% and six additional candidates (..
  57. Narayan G, Xie D, Ishdorj G, Scotto L, Mansukhani M, Pothuri B, et al. Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer. Genes Chromosomes Cancer. 2016;55:177-89 pubmed publisher
    ..candidate genes at MDR identified promoter hypermethylation and/or inactivation of decoy receptors TNFRSF10C and TNFRSF10D in the majority of CC patients...
  58. Varjak M, Donald C, Mottram T, Sreenu V, Merits A, Maringer K, et al. Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Negl Trop Dis. 2017;11:e0006010 pubmed publisher
    ..Enhanced ZIKV replication was observed in a Dcr2-knockout cell line suggesting that the exo-siRNA pathway is implicated in the antiviral response...
  59. Herbeuval J, Grivel J, Boasso A, Hardy A, Chougnet C, Dolan M, et al. CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis. Blood. 2005;106:3524-31 pubmed
    ..We propose a novel model in which a type 1 IFN-regulated TRAIL /DR5 mechanism induces apoptosis of HIV-1-exposed CD4(+) T cells. ..
  60. Sun S, Yue P, Chen X, Hong W, Lotan R. The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells. Cancer Res. 2002;62:2430-6 pubmed
    ..lung epithelial cells, which expressed constitutively higher levels of two antiapoptotic decoy receptors DcR1 and DcR2 than lung cancer cells, exhibited an increase in the expression of these receptors after CD437 treatment, whereas ..
  61. Pei G, Wu C, Lin W. Hypoxia-induced decoy receptor 2 gene expression is regulated via a hypoxia-inducible factor 1alpha-mediated mechanism. Biochem Biophys Res Commun. 2010;391:1274-9 pubmed publisher
    ..DR4 and DR5 can recruit Fas-associated death domain protein to induce extrinsic death signal, while DcR1 and DcR2 are decoy receptors that can neutralize TRAIL toxicity by binding to TRAIL...
  62. Robertson N, Zangrilli J, Steplewski A, Hastie A, Lindemeyer R, Planeta M, et al. Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival. J Immunol. 2002;169:5986-96 pubmed
    ..image analysis of BAL eosinophils and alveolar macrophages, which demonstrated that expression levels of TRAIL and DcR2 increased, whereas expression levels of the TRAIL-Rs DR4 and DR5 decreased in asthmatic subjects after SAC...
  63. Neale B, Medland S, Ripke S, Asherson P, Franke B, Lesch K, et al. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2010;49:884-97 pubmed publisher
    ..g., rare ones, account for much of the disorder's heritability. ..
  64. Zhang X, Franco A, Nguyen T, Gray C, Hersey P. Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells. J Immunol. 2000;164:3961-70 pubmed
  65. Lucas H, Bartold P, Dharmapatni A, Holding C, Haynes D. Inhibition of apoptosis in periodontitis. J Dent Res. 2010;89:29-33 pubmed publisher
    ..Higher levels of TRAIL and the TRAIL decoy receptor, TRAIL R4, were expressed in the diseased periodontal tissues (p < 0.005). Statistically (p < 0...
  66. Hasel C, Dürr S, Rau B, Strater J, Schmid R, Walczak H, et al. In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas. Lab Invest. 2003;83:825-36 pubmed
  67. Martínez Ferrandis J, Rodríguez López R, Milne R, Gonzalez E, Cebolla E, Chirivella I, et al. Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women. Cancer Biomark. 2007;3:89-93 pubmed
    ..TRAIL binds to the proapoptotic death receptor DR4 and DR5 as well as to the decoy receptors DcR1 and DcR2. To evaluate the involvement of TRAIL receptor genes in breast cancer, we carried out a case-control study of eight ..
  68. Gottwald L, Piekarski J, Kubiak R, Szwalski J, Pasz Walczak G, Sek P, et al. Membrane expression of TRAIL receptors DR4, DR5, DcR1 and DcR2 in the normal endometrium, atypical endometrial hyperplasia and endometrioid adenocarcinoma: a tissue microarray study. Arch Gynecol Obstet. 2013;288:889-99 pubmed publisher
    To evaluate the membrane expression of DR4, DR5, DcR1 and DcR2 in the normal endometrium (NE), atypical endometrial hyperplasia (AEH) and endometrioid adenocarcinoma (EAC). The study comprised 197 patients: 20 NE, 18 AEH and 159 EAC...
  69. Jang J, Jeon Y, Choi Y, Kim C. Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression. Mol Cancer. 2010;9:262 pubmed publisher up-regulating the expression of TRAIL death receptors 4 and 5 (DR4 and DR5) and down-regulating the TRAIL decoy receptor 2 (DcR2)...
  70. O Leary L, van der Sloot A, Reis C, Deegan S, Ryan A, Dhami S, et al. Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity. Oncogene. 2016;35:1261-70 pubmed publisher
    ..TRAIL induces cell death through binding to death receptors DR4 and DR5. The inhibitory decoy receptors (DcR1 and DcR2) co-expressed with death receptor 4 (DR4)/DR5 on the same cell can block the transmission of the apoptotic signal...
  71. Dorr J, Bechmann I, Waiczies S, Aktas O, Walczak H, Krammer P, et al. Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci. 2002;22:RC209 pubmed
    ..Conversely, this death receptor-ligand system might well play an important role in T cell-mediated autoimmune diseases of the CNS such as multiple sclerosis. ..
  72. Ou D, Metzger D, Wang X, Huang J, Pozzilli P, Tingle A. TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction. Diabetologia. 2002;45:1678-88 pubmed
    ..The TRAIL death pathway is present and can function in human islet beta cells, but unidentified inhibitors of the TRAIL death pathway are present in normal islet cells. ..
  73. Marsters S, Sheridan J, Pitti R, Huang A, Skubatch M, Baldwin D, et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol. 1997;7:1003-6 pubmed
    ..We subsequently named this protein decoy receptor 2 (DcR2). The DcR2 gene mapped to human chromosome 8p21, as did the genes encoding DR4, DR5 and DcR1...
  74. Gottwald L, Pasz Walczak G, Piekarski J, Szwalski J, Kubiak R, Spych M, et al. Membrane expression of trail receptors DcR1 and DcR2 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer. J Obstet Gynaecol. 2014;34:346-9 pubmed publisher
    We aimed to evaluate the membrane expression of DcR1 and DcR2 in the normal endometrium (NE), endometrial atypical hyperplasia (EAH) and endometrioid endometrial cancer (EEC). The study comprised 101 patients: 20 NE, 14 EAH and 67 EEC...
  75. Bisgin A, Terzioglu E, Aydin C, Yoldas B, Yazisiz V, Balci N, et al. TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2010;11:192 pubmed publisher
    ..Death Receptor-4 (DR4) and the decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4+ T cells, were positively correlated with patients' DAS scores...
  76. Herbeuval J, Hardy A, Boasso A, Anderson S, Dolan M, Dy M, et al. Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2005;102:13974-9 pubmed
    ..Our findings suggest a potential unique role of pDCs in the immunopathogenesis of HIV-1 infection by inducing the death molecule TRAIL. ..
  77. Zhu D, Shi J, Liu S, Liu Y, Zheng D. HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species. PLoS ONE. 2011;6:e18291 pubmed publisher
    ..model we demonstrate that HIV-1 PV infection down-regulates the expression of TRAIL decoy receptor 1 (DcR1) and 2 (DcR2), and cellular FLICE-inhibitory protein (c-FLIP), but dose not affect the expression of death receptor 4 and 5 (DR4,..