Gene Symbol: TNFAIP1
Description: TNF alpha induced protein 1
Alias: B12, B61, BTBD34, EDP1, hBACURD2, BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, BTB/POZ domain-containing protein TNFAIP1, tumor necrosis factor, alpha induced protein 1, tumor necrosis factor, alpha-induced protein 1 (endothelial)
Species: human
Products:     TNFAIP1

Top Publications

  1. Wolf F, Marks R, Sarma V, Byers M, Katz R, Shows T, et al. Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. J Biol Chem. 1992;267:1317-26 pubmed
    ..One of these cDNAs, designated B12, is further characterized here. B12 is encoded by a 3...
  2. Liu M, Sun Z, Zhou A, Li H, Yang L, Zhou C, et al. Functional characterization of the promoter region of human TNFAIP1 gene. Mol Biol Rep. 2010;37:1699-705 pubmed publisher
    Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an immediate-early response gene of endothelium induced by TNF alpha. However, little is really known concerning the TNFAIP1 expression regulation...
  3. Lang U, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem. 2013;31:761-77 pubmed publisher
    ..acids, monounsaturated fatty acids, olive oil, fish, fruits, vegetables, nuts, legumes, vitamin B6 and vitamin B12. The neurodegenerative hypothesis of depression explains decreased hippocampal volumes in depressed patients and ..
  4. Sawczuk R, Karpinska J, Miltyk W. What do we know and what we would like to know about drone homogenate. J Ethnopharmacol. 2018;: pubmed publisher
    ..7g/100g), carbohydrates (17.8g/100g) and lipids (21.9g/100g). LDBH were marked with B vitamins (B2, B3, B5, B6, B12), folic acid, biotin, choline, inositol as well as high content of macroelements (potassium, magnesium, sodium, ..
  5. Missoum H, Alami M, Aouad R, Bakri Y, Bouyahya A, Rhajaoui M, et al. Prevalence of autoimmune diseases and clinical significance of autoantibody profile: data from National Institute of Hygiene in Rabat, Morocco. Hum Immunol. 2019;: pubmed publisher
    ..hepatitis C (HCV) , and autoimmune hepatitis (AIH) and anti-PCA was higher in biermer anemia patients with vitamin B12 deficiency (BA/Def vit B12)...
  6. Ji Y, Wu Z, Dai Z, Sun K, Wang J, Wu G. Nutritional epigenetics with a focus on amino acids: implications for the development and treatment of metabolic syndrome. J Nutr Biochem. 2016;27:1-8 pubmed publisher
    ..Amino acids (e.g., glycine, histidine, methionine and serine) and vitamins (B6, B12 and folate) play key roles in provision of methyl donors for DNA and protein methylation...
  7. Xu B, Kong X, Xu R, Song Y, Liu L, Zhou Z, et al. Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism. Medicine (Baltimore). 2017;96:e5862 pubmed publisher
    ..were estimated by Cox proportional-hazard regression models, adjusting for age, sex, baseline folate, vitamin B12, blood pressure, body mass index, smoking and alcohol drinking status, study center, total cholesterol, ..
  8. Salehi Abargouei A, Esmaillzadeh A, Azadbakht L, Keshteli A, Feizi A, Feinle Bisset C, et al. Nutrient patterns and their relation to general and abdominal obesity in Iranian adults: findings from the SEPAHAN study. Eur J Nutr. 2016;55:505-518 pubmed publisher
    ..high in fatty acids (including saturated, monounsaturated and polyunsaturated fatty acids), cholesterol, vitamin B12, vitamin E, zinc, choline, protein, pyridoxine, phosphorus and pantothenic acid; (2) the second pattern was high in ..
  9. Berti V, Murray J, Davies M, Spector N, Tsui W, Li Y, et al. Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals. J Nutr Health Aging. 2015;19:413-23 pubmed publisher
    ..and PUFA]; NP3 by vitamin A, vitamin C, carotenoids and dietary fibers [Anti-oxidants and Fibers]; NP4 by vitamin B12, vitamin D and zinc [VitB12 and D]; NP5 by saturated, trans-saturated fats, cholesterol and sodium [Fats]...

More Information

Publications158 found, 100 shown here

  1. Nadesalingam A, Chen J, Farahvash A, Khan M. Hypertonic Saline Suppresses NADPH Oxidase-Dependent Neutrophil Extracellular Trap Formation and Promotes Apoptosis. Front Immunol. 2018;9:359 pubmed publisher
    ..oxidase (NADPH2 or NOX2)-dependent NETosis induced by agonists PMA, Escherichia coli LPS (0111:B4 and O128:B12), and P. aeruginosa...
  2. Lopes da Silva S, Vellas B, Elemans S, Luchsinger J, Kamphuis P, Yaffe K, et al. Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis. Alzheimers Dement. 2014;10:485-502 pubmed publisher
    ..We identified five or more studies for folate, vitamin A, vitamin B12, vitamin C, vitamin D, vitamin E, copper, iron, and zinc but fewer than five studies for vitamins B1 and B6, long-..
  3. Cornea M, Levrat E, Pugin P, Betticher D. BCR-ABL1- positive chronic myeloid leukemia with erythrocytosis presenting as polycythemia vera: a case report. J Med Case Rep. 2015;9:30 pubmed publisher
    ..Taken together with a high vitamin B12 level, we conducted a Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 gene analysis and ..
  4. Singhal N, Li S, Arning E, Alkhayer K, Clements R, Sarcyk Z, et al. Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis. J Neurosci. 2015;35:15170-86 pubmed publisher
    ..For decades, it has been observed that vitamin B12 deficiency and multiple sclerosis (MS) share certain pathological changes, including conduction disturbances...
  5. Daulatzai M. Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease. J Neurosci Res. 2017;95:943-972 pubmed publisher
    Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse pathological mechanisms including cerebral hypoperfusion ..
  6. Khayyatzadeh S, Moohebati M, Mazidi M, Avan A, Tayefi M, Parizadeh S, et al. Nutrient patterns and their relationship to metabolic syndrome in Iranian adults. Eur J Clin Invest. 2016;46:840-52 pubmed publisher
    ..iodine, vitamin D, chloride, betaine, niacin; third consisting of copper, selenium, vitamin A, riboflavin, vitamin B12. In this dietary pattern, individuals in first quintile had a higher consumption of total fat, saturated fatty acid,..
  7. Martínez García R, Jiménez Ortega A, López Sobaler A, Ortega R. [Nutrition strategies that improve cognitive function]. Nutr Hosp. 2018;35:16-19 pubmed publisher
    ..Vitamins B1, B6, B12, B9 (folic acid) and D, choline, iron and iodine exert neuroprotective effects and improve intellectual performance...
  8. Yan T, Lin G, Wang M, Lamkowski A, Port M, Rump A. Pharmacological treatment of inhalation injury after nuclear or radiological incidents: The Chinese and German approach. Mil Med Res. 2019;6:10 pubmed publisher
    ..Methemoglobin-forming agents (e.g., nitrites, dimethylaminophenol) or hydroxocobalamin (Vitamin B12) are options. The metabolic elimination of cyanide may be enhanced by sodium thiosulfate...
  9. Hall J, Mason J, Choi J, Holguin M. B12 deficiency leading to marked poikilocytosis versus true schistocytosis, a pernicious problem. Transfus Apher Sci. 2017;56:576-577 pubmed publisher
    Severe vitamin B12 deficiency is caused most commonly by autoimmune atrophic gastritis leading to loss of intrinsic factor...
  10. Kizilgul M, Ozcelik O, Beysel S, Akinci H, Kan S, Ucan B, et al. Screening for celiac disease in poorly controlled type 2 diabetes mellitus: worth it or not?. BMC Endocr Disord. 2017;17:62 pubmed publisher
    ..fasting plasma glucose, postprandial plasma glucose, urea, sodium, HbA1c, LDL-C, triglyceride, vitamin B12 levels were significantly higher in DM group (p < 0.0001)...
  11. Zímová J, Zímová P. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Acta Dermatovenerol Croat. 2016;24:150-3 pubmed
    ..Laboratory tests (blood count, iron, ferritin, transferrin, selenium, zinc, vitamin B12, folic acid, serology and hormones of thyroid gland) were negative...
  12. Acharyya N, Deb B, Chattopadhyay S, Maiti S. Arsenic-Induced Antioxidant Depletion, Oxidative DNA Breakage, and Tissue Damages are Prevented by the Combined Action of Folate and Vitamin B12. Biol Trace Elem Res. 2015;168:122-32 pubmed publisher
    ..The -CH3 group helps in arsenic disposition and detoxification of the biological systems. Vitamin B12 and folate, the key promoters of 1C metabolism were tested recently (daily 0.07 and 4...
  13. Mihrshahi S, Gow M, Baur L. Contemporary approaches to the prevention and management of paediatric obesity: an Australian focus. Med J Aust. 2018;209:267-274 pubmed
    ..can be associated with micronutrient deficiencies, it may be prudent to check full blood count and iron, vitamin B12 and vitamin D levels. Endocrinological assessment is usually not needed...
  14. Fakruddin M, Hossain M, Ahmed M. Antimicrobial and antioxidant activities of Saccharomyces cerevisiae IFST062013, a potential probiotic. BMC Complement Altern Med. 2017;17:64 pubmed publisher
    ..It can assimilate cholesterol, can produce killer toxin, vitamin B12, glutathione, siderophore and strong biofilm...
  15. Fusaro M, D Alessandro C, Noale M, Tripepi G, Plebani M, Veronese N, et al. Low vitamin K1 intake in haemodialysis patients. Clin Nutr. 2017;36:601-607 pubmed publisher
    ..With the exception of vitamin B12, vitamins intake followed a similar pattern, with a lower intake in vitamin A, B1, B2, C, D, E, folates, K1 and PP...
  16. Ammouri W, Tazi Z, Harmouche H, Maamar M, Adnaoui M. Venous thromboembolism and hyperhomocysteinemia as first manifestation of pernicious anemia: a case series. J Med Case Rep. 2017;11:250 pubmed publisher
    ..Homocysteine is due to genetic and acquired factors (poor diet in folate and vitamin B12, older age, renal impairment, thyroid diseases, and malignancies) induced by the intake and the concentrations of ..
  17. Hacibekiroglu T, Basturk A, Akinci S, Bakanay S, Ulas T, Guney T, et al. Evaluation of serum levels of zinc, copper, and Helicobacter pylori IgG and IgA in iron deficiency anemia cases. Eur Rev Med Pharmacol Sci. 2015;19:4835-40 pubmed
    ..Serum zinc, copper, H. pylori immunoglobulin A (HpIgA) and immunoglobulin G (HpIgG), vitamin B12, and folic acid levels were examined in the blood specimens collected...
  18. Kose E, Arslan N. Vitamin/mineral and micronutrient status in patients with classical phenylketonuria. Clin Nutr. 2019;38:197-203 pubmed publisher
    ..Biochemical and hematological markers including hemoglobin, serum vitamin B12, folic acid, iron, ferritin, transferrin saturation, copper, prealbumin, albumin, total protein, phosphorus, ..
  19. Ottini L, Rizzolo P, Siniscalchi E, Zijno A, Silvestri V, Crebelli R, et al. Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. Mutat Res Genet Toxicol Environ Mutagen. 2015;779:57-64 pubmed publisher
    ..Plasma levels of folic acid, vitamin B12 and homocysteine were also available from a previous investigation...
  20. Liu L, Hu J, Ma J, Li X, Li F, Li C. [A case of autoimmune lymphoproliferactive syndrome and literature review]. Zhonghua Er Ke Za Zhi. 2014;52:923-6 pubmed
    ..hypergammaglobulinemia (IgG 19 800 mg/L, IgA 1 710 mg/L, IgM 2 590 mg/L) and significantly increased serum vitamin B12. Flow cytometric measures showed that CD3⁺ CD4⁻ CD8⁻ T lymphocytes significantly increased ( > 10%..
  21. Sánchez A, Rojas P, Basfi fer K, Carrasco F, Inostroza J, Codoceo J, et al. Micronutrient Deficiencies in Morbidly Obese Women Prior to Bariatric Surgery. Obes Surg. 2016;26:361-8 pubmed publisher
    ..Folic acid, vitamin B12, vitamin D, and parathyroid hormone (PTH) were also assessed in 66 subjects...
  22. Wojcieszek J, Ruzik L. Operationally defined species characterization and bioaccessibility evaluation of cobalt, copper and selenium in Cape gooseberry (Physalis Peruviana L.) by SEC-ICP MS. J Trace Elem Med Biol. 2016;34:15-21 pubmed publisher
    ..Investigation of available standards of cobalt and selenium allows confirming the presence of vitamin B12 and probably selenomethionine in the fraction bioaccessible by human body (obtained during enzymatic extraction)...
  23. Lallès J. Dairy products and the French paradox: Could alkaline phosphatases play a role?. Med Hypotheses. 2016;92:7-11 pubmed publisher
    ..g. vitamins A and D; methyl-donors: folate and vitamin B12), and also fermentation products such as butyrate and propionate found e.g...
  24. Jung Y, Earnest C, Koozehchian M, Cho M, Barringer N, Walker D, et al. Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males. J Int Soc Sports Nutr. 2017;14:1 pubmed publisher
    ..15 mg), Vitamin C as Ascorbic Acid (500 mg), niacin (60 mg), folate as folic acid (50 mg), and Vitamin B12 as Methylcobalamin (70 mg); or, the PWS supplement with Citrus aurantium extract containing 20 mg of ..
  25. Shet A, Bhavani P, Kumarasamy N, Arumugam K, Poongulali S, Elumalai S, et al. Anemia, diet and therapeutic iron among children living with HIV: a prospective cohort study. BMC Pediatr. 2015;15:164 pubmed publisher
    ..included iron markers (ferritin, soluble transferrin receptor) and other micronutrient levels (vitamin A, B12, folate). Iron was given to anemic children based on WHO guidelines...
  26. Castoro C, Le Moli R, Arpi M, Tavarelli M, Sapuppo G, Frittitta L, et al. Association of autoimmune thyroid diseases, chronic atrophic gastritis and gastric carcinoid: experience from a single institution. J Endocrinol Invest. 2016;39:779-84 pubmed publisher
    ..In the period 2004-2014, 242 patients with ATD underwent a screening performing APCA, Vitamin B12, ferritin, iron, and hemoglobin and red cells count measurements with subsequent gastroscopy in case of APCA ..
  27. Shalini T, Sivaprasad M, Balakrishna N, Madhavi G, Radhika M, Kumar B, et al. Micronutrient intakes and status assessed by probability approach among the urban adult population of Hyderabad city in South India. Eur J Nutr. 2018;: pubmed publisher
    ..Hemoglobin in whole blood, ferritin, folate, and vitamin B12 (B12) in plasma was estimated...
  28. Singh A, Trumpff C, Genkinger J, Davis A, Spann M, Werner E, et al. Micronutrient Dietary Intake in Latina Pregnant Adolescents and Its Association with Level of Depression, Stress, and Social Support. Nutrients. 2017;9: pubmed publisher
    ..Additionally, >20% of participants had an inadequate intake of thiamin, riboflavin, niacin, vitamin B6, vitamin B12, vitamin C, copper, and selenium...
  29. Gominak S. Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and auto. Med Hypotheses. 2016;94:103-7 pubmed publisher
    ..replacement slowly induced a secondary pantothenic acid deficiency, B100 (100mg of all B vitamins except 100mcg of B12 and biotin and 400mcg of folate) was added to vitamin D supplementation...
  30. Gobato R, Seixas Chaves D, Chaim E. Micronutrient and physiologic parameters before and 6 months after RYGB. Surg Obes Relat Dis. 2014;10:944-51 pubmed publisher, food consumption, and total protein serum levels, albumin, prealbumin, parathyroid hormone (PTH), zinc (Zn), B12 vitamin (VitB12), iron (Fe), ferritin, copper (Cu), ionic calcium (CaI), magnesium (Mg), and folic acid were ..
  31. Waśkiewicz A, Szcześniewska D, Szostak Węgierek D, Kwaśniewska M, Pająk A, Stepaniak U, et al. Are dietary habits of the Polish population consistent with the recommendations for prevention of cardiovascular disease? - WOBASZ II project. Kardiol Pol. 2016;74:969-77 pubmed publisher
    ..The diet of most adult Polish citizens was found to be not balanced. Vitamins A, C, E, B1, B2, B6, and B12, protein, dietary cholesterol and fruits/vegetables were consumed in recommended doses only by 44-80% of the ..
  32. Laird E, Casey M, Ward M, Hoey L, Hughes C, McCarroll K, et al. Dairy Intakes in Older Irish Adults and Effects on Vitamin Micronutrient Status: Data from the TUDA Study. J Nutr Health Aging. 2017;21:954-961 pubmed publisher
    ..Blood samples were analysed for vitamin biomarkers as follows: vitamin B12 (total serum cobalamin and holotranscobalamin (holoTC)), folate (red cell folate (RCF) and serum folate), vitamin ..
  33. Torbergsen A, Watne L, Wyller T, Frihagen F, Strømsøe K, Bøhmer T, et al. Micronutrients and the risk of hip fracture: Case-control study. Clin Nutr. 2017;36:438-443 pubmed publisher
    ..In this case-control study, blood was drawn for measurements of vitamins A, B6, B12, C, E, and folic acid as well as the bone turnover markers osteocalcin and bone-specific alkaline phosphatase upon ..
  34. Obeid R, Awwad H, Keller M, Geisel J. Trimethylamine-N-oxide and its biological variations in vegetarians. Eur J Nutr. 2017;56:2599-2609 pubmed publisher
    ..2 ± 7.3 years) that was tested twice within 3 months of intervention with vitamin B12 or a placebo. In group 1, plasma TMAO did not differ according to the strictness of the diet (both means 3...
  35. Romeo B, Choucha W, Fossati P, Rotge J. [Clinical and biological predictors of ketamine response in treatment-resistant major depression: Review]. Encephale. 2017;43:354-362 pubmed publisher
    ..of glutamine/glutamate), inflammatory factors (IL-6 concentration) or metabolic factors (concentration of B12 vitamin, D- and L-serine, alterations in the mitochondrial ?-oxidation of fatty acids)...
  36. Howe C, Liu X, Hall M, Ilievski V, Caudill M, Malysheva O, et al. Sex-Specific Associations between One-Carbon Metabolism Indices and Posttranslational Histone Modifications in Arsenic-Exposed Bangladeshi Adults. Cancer Epidemiol Biomarkers Prev. 2017;26:261-269 pubmed publisher
    ..Sex-specific associations between several blood OCM indices (folate, vitamin B12, choline, betaine, homocysteine) and PTHMs were examined at baseline using regression models, adjusted for multiple ..
  37. Kulkarni G, Singh R, Gadad V, Ramakrishnan S, Mustare V. Unilateral Papilledema in Cerebral Venous Sinus Thrombosis. J Neurosci Rural Pract. 2017;8:S106-S110 pubmed publisher
    ..The risk factors found on evaluation were Vitamin B12 deficiency and hyperhomocysteinemia...
  38. Nabhani S, Ginzel S, Miskin H, Revel Vilk S, Harlev D, Fleckenstein B, et al. Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease. Haematologica. 2015;100:1189-98 pubmed publisher
    ..hepatomegaly, elevated numbers of double-negative T cells, autoimmune cytopenias, and increased levels of vitamin B12 and interleukin-10...
  39. Li X, Grant O, Ito K, Wallace A, Wang S, Zhao P, et al. Structural Analysis of the Glycosylated Intact HIV-1 gp120-b12 Antibody Complex Using Hydroxyl Radical Protein Footprinting. Biochemistry. 2017;56:957-970 pubmed publisher
    ..Here, the interaction of full-length, glycosylated gp120 with bNAb b12 is probed using high-resolution hydroxyl radical protein footprinting (HR-HRPF) by fast photochemical oxidation of ..
  40. Pellitero S, Martínez E, Puig R, Leis A, Zavala R, Granada M, et al. Evaluation of Vitamin and Trace Element Requirements after Sleeve Gastrectomy at Long Term. Obes Surg. 2017;27:1674-1682 pubmed publisher
    ..Frequencies of deficiencies for folic acid, B12, B6, and B1 vitamins decreased significantly after 2 years with normalization at 5 years...
  41. Llobet Vila L, Manresa Domínguez J, Carmona Segado J, Franzi Sisó A, Vallès Balasch R, Martínez Díaz I. [Facing a dilemma in elderly complex and vulnerable patients: to stop or not to stop prevention?]. Aten Primaria. 2017;: pubmed publisher
    1-To know the preventive prescription (statin, antiplatelet drugs, bisphosphonates, calcium and vitamin D and Vit B12) of elderly patients previously identified as a CCD (with a complex chronic disease) and ACD (with advanced chronic ..
  42. Wassenaar J, Boss G, Christman K. Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials. 2015;64:108-14 pubmed publisher
    ..We validated the model using the vitamin B12 analog cobinamide with different bound ligands...
  43. Cappellini M, Motta I. Anemia in Clinical Practice-Definition and Classification: Does Hemoglobin Change With Aging?. Semin Hematol. 2015;52:261-9 pubmed publisher
    ..In one third of the patients, anemia is due to nutritional deficiency, including iron, folate, or vitamin B12 deficiency; moreover, anemia of chronic disease accounts for about another third of the cases...
  44. Selhub J, Rosenberg I. Excessive folic acid intake and relation to adverse health outcome. Biochimie. 2016;126:71-8 pubmed publisher
    ..and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid...
  45. Duplessis M, Lapierre H, Ouattara B, Bissonnette N, Pellerin D, Laforest J, et al. Whole-body propionate and glucose metabolism of multiparous dairy cows receiving folic acid and vitamin B12 supplements. J Dairy Sci. 2017;100:8578-8589 pubmed publisher
    ..Our results suggest that the folic acid supplement reduced glucose-derived lactose synthesis by redirecting glucose for other metabolic activity in the mammary gland or in other tissues. ..
  46. Stone K, Lui L, Christen W, Troen A, Bauer D, Kado D, et al. Effect of Combination Folic Acid, Vitamin B6 , and Vitamin B12 Supplementation on Fracture Risk in Women: A Randomized, Controlled Trial. J Bone Miner Res. 2017;32:2331-2338 pubmed publisher
    ..2017 American Society for Bone and Mineral Research...
  47. Bass R, Locher K, Borths E, Poon Y, Strop P, Lee A, et al. The structures of BtuCD and MscS and their implications for transporter and channel function. FEBS Lett. 2003;555:111-5 pubmed
    ..of two bacterial transport systems, the stretch-activated mechanosensitive channel of small conductance (MscS) and the ATP-dependent vitamin B12 uptake system (BtuCD), emphasizing their general implications for transporter function.
  48. Liu H, Chiu S. The Effectiveness of Vitamin B12 for Relieving Pain in Aphthous Ulcers: A Randomized, Double-blind, Placebo-controlled Trial. Pain Manag Nurs. 2015;16:182-7 pubmed publisher
    ..Our objective was to confirm the analgesic benefit of treatment of mouth ulcers with vitamin B12 as adjunctive therapy...
  49. Durán Agüero S, González Cañete N, Peña D Ardaillon F, Candia Johns P. [Association of intake macro and micronutrients with life quality of life in elderly]. Nutr Hosp. 2015;31:2578-82 pubmed publisher
    ..166; p = 0.001), responsibility for health (0.171; p = 0.001) and exercise (r = 0.167; p = 0.001); the vitamin B12 was a protective factor to have a better quality of life OR = 0.78 (IC95% 0.67-0.90)...
  50. Fogelman Y, Kitai E, Blumberg G, Golan Cohen A, Rapoport M, Carmeli E. Vitamin B12 screening in metformin-treated diabetics in primary care: were elderly patients less likely to be tested?. Aging Clin Exp Res. 2017;29:135-139 pubmed publisher
    Low serum B12 level is a common occurrence in patients with type 2 diabetes (T2DM) treated with metformin...
  51. Komeyama K, Ohata R, Kiguchi S, Osaka I. Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates. Chem Commun (Camb). 2017;53:6401-6404 pubmed publisher
    ..The tosylate was activated by reduced VB12 to form alkyl cobalt(iii), which served as a good alkylating agent for aryl-nickel species, leading to C(sp3)-C(sp2) bond formation. ..
  52. Park S, de Perre C, Lee L. Alternate Reductants with VB12 to Transform C8 and C6 Perfluoroalkyl Sulfonates: Limitations and Insights into Isomer-Specific Transformation Rates, Products and Pathways. Environ Sci Technol. 2017;: pubmed publisher
    Previous studies evaluating Vitamin B12 (VB12) with Ti(III)-citrate for potential use in in situ remediation of perfluorooctanesulfonate (PFOS) found that linear (L)-PFOS was unaltered...
  53. Oster M, Nuchchanart W, Trakooljul N, Muráni E, Zeyner A, Wirthgen E, et al. Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight. Eur J Nutr. 2016;55:1717-27 pubmed publisher
    ..In particular, dietary levels of methylating micronutrients (methionine, folate, choline, vitamins B6, and B12) interfere with the availability and allocation of methyl groups for methylation reactions, thereby influencing ..
  54. Wong J, Haszard J, Howe A, Parnell W, Skidmore P. Development of a Healthy Dietary Habits Index for New Zealand Adults. Nutrients. 2017;9: pubmed publisher
    ..including calcium, iron, and vitamin C, and lower intakes of energy, macronutrients, sodium, zinc, vitamins B6 and B12. Associations in the expected directions were also found for urinary sodium, whole blood folate, serum and red ..
  55. Piwowarek K, Lipińska E, Hać Szymańczuk E, Kieliszek M, Scibisz I. Propionibacterium spp.-source of propionic acid, vitamin B12, and other metabolites important for the industry. Appl Microbiol Biotechnol. 2018;102:515-538 pubmed publisher
    ..of the bacteria from the Propionibacterium genus constitutes sources of vitamins from the B group, including B12, trehalose, and numerous bacteriocins...
  56. De Simone V, Dalmoro A, Lamberti G, Caccavo D, d Amore M, Barba A. HPMC granules by wet granulation process: Effect of vitamin load on physicochemical, mechanical and release properties. Carbohydr Polym. 2018;181:939-947 pubmed publisher
    ..In this work, vitamin B12 loaded HPMC granules were produced to investigate their potential application as nutraceutical products...
  57. Keskin M, Ural D, Altay S, Argan O, Börklü E, Kozan O. Iron deficiency and hematinic deficiencies in atrial fibrillation: A new insight into comorbidities. Turk Kardiyol Dern Ars. 2018;46:103-110 pubmed publisher
    ..of iron (serum ferritin <100 µg/L or ferritin 100-299 µg/L with transferrin saturation <20%), vitamin B12 (<200 pg/mL), and folate deficiency (<4...
  58. Manios Y, Moschonis G, Dekkers R, Mavrogianni C, Grammatikaki E, van den Heuvel E. Vitamin B2, vitamin B12 and total homocysteine status in children and their associations with dietary intake of B-vitamins from different food groups: the Healthy Growth Study. Eur J Nutr. 2017;56:321-331 pubmed publisher
    ..However, these findings need to be further confirmed from controlled dietary intervention studies examining the modulation of biomarkers of B-vitamins. ..
  59. Santoro G, Beltrami R, Kottelat E, Blacque O, Bogdanova A, Zobi F. N-Nitrosamine-{cis-Re[CO]2}(2+) cobalamin conjugates as mixed CO/NO-releasing molecules. Dalton Trans. 2016;45:1504-13 pubmed publisher
    ..of the 17-electron rhenium dicarbonyl cis-[Re(CO)2Br4](2-) complex to N-nitrosamine modified cyanocobalamin (B12) bio-vectors...
  60. Liu X, Liu J, Xiong X, Yang T, Hou N, Liang X, et al. Correlation between Nutrition and Symptoms: Nutritional Survey of Children with Autism Spectrum Disorder in Chongqing, China. Nutrients. 2016;8: pubmed publisher
    ..The serum ferritin, folate, vitamin B12, 25(OH) vitamin D, and vitamin A concentrations in the children with ASD were determined...
  61. Moubarac J, Batal M, Louzada M, Martinez Steele E, Monteiro C. Consumption of ultra-processed foods predicts diet quality in Canada. Appetite. 2017;108:512-520 pubmed publisher
    ..while an inverse relationship was observed with the dietary content in protein, fiber, vitamins A, C, D, B6 and B12, niacin, thiamine, riboflavin, as well as zinc, iron, magnesium, calcium, phosphorus and potassium...
  62. Aşkar T, Büyükleblebici O, Hişmioğullari A, Hünkerler Z. Oxidative stress, hepcidin and nesfatin-I status in childhood iron and vitamin B12 deficiency anemias. Adv Clin Exp Med. 2017;26:621-625 pubmed publisher
    Anemia is a disease that is long and often repetitive and can result in a great burden to the national economy. The most frequent nutritional deficiency anemias in children are related with iron and vitamin B12 deficiencies.
  63. Adaikalakoteswari A, Vatish M, Alam M, Ott S, Kumar S, Saravanan P. Low Vitamin B12 in Pregnancy Is Associated With Adipose-Derived Circulating miRs Targeting PPAR? and Insulin Resistance. J Clin Endocrinol Metab. 2017;102:4200-4209 pubmed publisher
    Low vitamin B12 during pregnancy is associated with higher maternal obesity, insulin resistance (IR), and gestational diabetes mellitus. B12 is a key cofactor in one-carbon metabolism.
  64. Scott T, Rogers G, Weiner D, Livingston K, Selhub J, Jacques P, et al. B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial. J Prev Alzheimers Dis. 2017;4:174-182 pubmed publisher
    ..The intervention consisted of a daily multivitamin containing high-doses of folate (5.0 mg), vitamin B12 (1.0 mg) and vitamin B6 (50 mg)...
  65. Vidoni M, Pettee Gabriel K, Luo S, Simonsick E, Day R. Vitamin B12 and Homocysteine Associations with Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging. J Nutr Health Aging. 2017;21:1321-1328 pubmed publisher
    This study aimed to assess the independent associations of serum levels of vitamin B12 and plasma concentrations of homocysteine with gait speed decline...
  66. Oliveira C, Augusto R, Muniz P, da Silva S, Cardoso M. Anemia and micronutrient deficiencies in infants attending at Primary Health Care in Rio Branco, Acre, Brazil. Cien Saude Colet. 2016;21:517-29 pubmed publisher
    ..blood samples were obtained to assess the occurrence of anemia and deficiencies of iron (ID), vitamin A (VAD), and B12 (VB12D). Multiple Poisson regression models were used to identify factors associated with anemia...
  67. Latov N, Vo M, Chin R, Carey B, Langsdorf J, Feuer N. Abnormal Nutritional Factors in Patients Evaluated at a Neuropathy Center. J Clin Neuromuscul Dis. 2016;17:212-4 pubmed publisher
    ..Elevated levels of pyridoxal phosphate or mercury occurred more frequently than deficiencies in vitamins B1, B12, or B6. The nutritional abnormalities are amenable to correction by dietary intervention.
  68. Arora K, Sequeira J, Quadros E. Maternofetal transport of vitamin B12: role of TCblR/CD320 and megalin. FASEB J. 2017;31:3098-3106 pubmed publisher
    ..Arora, K., Sequeira, J. M., Quadros, E. V. Maternofetal transport of vitamin B12: role of TCblR/CD320 and megalin. ..
  69. Martínez Hernández G, Castillejo N, Carrión Monteagudo M, Artes F, Artés Hernández F. Nutritional and bioactive compounds of commercialized algae powders used as food supplements. Food Sci Technol Int. 2018;24:172-182 pubmed publisher
    The main nutritional/bioactive compounds (protein; aminoacids, AA; fucose; minerals; vitamins B12 and C; and total phenolic content, TPC) of nine commercial algae powders, used as food supplements, were studied...
  70. Schmidt S, Gendron E, Vincent K, Solon A, Sommers P, Schubert Z, et al. Life at extreme elevations on Atacama volcanoes: the closest thing to Mars on Earth?. Antonie Van Leeuwenhoek. 2018;111:1389-1401 pubmed publisher
    ..a.s.l. on Volcán Llullaillaco) belongs to the enigmatic B12-WMSP1 clade which is related to the Ktedonobacter/Thermosporothrix clade that includes versatile organisms with the ..
  71. Dutchak P, Laxman S, Estill S, Wang C, Wang Y, Wang Y, et al. Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015;12:371-9 pubmed publisher
    ..KO embryos have significantly reduced methionine levels and exhibit phenotypes reminiscent of cobalamin (vitamin B12) deficiency...
  72. Keller S, Treder A, von Reuss S, Escalante Semerena J, Schubert T. The SMUL_1544 Gene Product Governs Norcobamide Biosynthesis in the Tetrachloroethene-Respiring Bacterium Sulfurospirillum multivorans. J Bacteriol. 2016;198:2236-43 pubmed publisher
    ..PCE)-respiring bacterium Sulfurospirillum multivorans produces a unique cobamide, namely, norpseudo-B12, which, in comparison to other cobamides, e.g...
  73. Smith A, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016;36:211-39 pubmed publisher
    ..Most homocysteine-lowering trials with folate and vitamins B6 and/or B12 tested as protective agents against cognitive decline were poorly designed by including subjects unlikely to ..
  74. Świontek M, Rożniakowski K, Fraczyk J, Lipiński W, Galecki K, Wysocki S, et al. The quest for the shortest fragments of A (13-19) and B (12-17) responsible for the aggregation of human insulin. Nanomedicine (Lond). 2016;11:2083-101 pubmed publisher
    To identify the shortest components of A13-A19, B12-B17 fragments capable for fibrillation and to validate the dependability of aggregation on the presence of hydroxyl group engaged in the 'tyrosine kissing'...
  75. Ouattara B, Bissonnette N, Duplessis M, Girard C. Supplements of vitamins B9 and B12 affect hepatic and mammary gland gene expression profiles in lactating dairy cows. BMC Genomics. 2016;17:640 pubmed publisher
    A combined supplement of vitamins B9 and B12 was reported to increase milk and milk component yields of dairy cows without effect on feed intake...
  76. Shen H, Campanello G, Flicker D, Grabarek Z, Hu J, Luo C, et al. The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12. Cell. 2017;171:771-782.e11 pubmed publisher
    ..Our work de-orphans the function of human CLYBL and reveals that a consequence of exposure to the immunomodulatory metabolite itaconate is B12 inactivation. ..
  77. Klurfeld D. Research gaps in evaluating the relationship of meat and health. Meat Sci. 2015;109:86-95 pubmed publisher
    ..Meat is one of the most nutrient dense foods, providing high-quality protein, heme iron, zinc, and vitamins B6 and B12. Despite these advantages, epidemiologic studies have linked consumption of red or processed meat with obesity, ..
  78. Liu C, Yang Y, Peng D, Chen L, Luo J. Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease. Saudi Med J. 2015;36:839-46 pubmed publisher
    ..18-34.46). The Hcy was negatively correlated with folic acid (r=-0.67, p less than 0.001) and vitamin B12 (r=-0.56, p less than 0.001). Of the CHD patients with HHcy, 51...
  79. Adachi Y, Kikumori T, Miyajima N, Inaishi T, Onishi E, Shibata M, et al. Postoperative elevation of CA15-3 due to pernicious anemia in a patient without evidence of breast cancer recurrence. Surg Case Rep. 2015;1:126 pubmed publisher
    ..Based on the findings of blood tests and gastroendoscopy, a diagnosis of pernicious anemia due to vitamin B12 deficiency was finally confirmed at 2 years and 6 months postoperatively...
  80. Ben Porat T, Elazary R, Goldenshluger A, Sherf Dagan S, Mintz Y, Weiss R. Nutritional deficiencies four years after laparoscopic sleeve gastrectomy-are supplements required for a lifetime?. Surg Obes Relat Dis. 2017;13:1138-1144 pubmed publisher
    ..2%, 28.6%), anemia (11.5%, 20%, 18.5%), folate (46%, 14.3%, 12.5%), vitamin B12 (7.7%, 13.6%, 15.4%), vitamin D (96.2%, 89%, 86%), and elevated parathyroid hormone (PTH) (52%, 15.4%, 60%)...
  81. Lee Y, Collins C, Gordon A, Rae K, Pringle K. The Relationship between Maternal Nutrition during Pregnancy and Offspring Kidney Structure and Function in Humans: A Systematic Review. Nutrients. 2018;10: pubmed publisher
    ..Nutrients reviewed to date included vitamin A (n = 3), folate and vitamin B12 (n = 2), iron (n = 1), vitamin D (n = 1), total energy (n = 2) and protein (n = ..
  82. Hvorup R, Goetz B, Niederer M, Hollenstein K, Perozo E, Locher K. Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF. Science. 2007;317:1387-90 pubmed
    BtuCD is an adenosine triphosphate-binding cassette (ABC) transporter that translocates vitamin B12 from the periplasmic binding protein BtuF into the cytoplasm of Escherichia coli. The 2...
  83. Palou Mir J, Musiari A, Sigel R, Barceló Oliver M. Characterization of the full-length btuB riboswitch from Klebsiella pneumoniae. J Inorg Biochem. 2016;160:106-13 pubmed publisher
    ..In the genome of Klebsiella pneumoniae a sequence was identified by bioinformatics and proposed to be a B12 riboswitch regulated by coenzyme B12...
  84. Gunes A, Aktar F, Tan I, Soker M, Uluca U, Balik H, et al. Urinary levels of early kidney injury molecules in children with vitamin B12 deficiency. Arch Argent Pediatr. 2016;114:453-7 pubmed publisher
    ..A (NAG), and neutrophil gelatinase-associated lipocalin (NGAL) in children with vitamin B12 (cobalamin) deficiency (CD)...
  85. Jeruszka Bielak M, Isman C, Schroder T, Li W, Green T, Lamers Y. South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women. Nutrients. 2017;9: pubmed publisher
    Vitamin B12 (B12) adequacy during pregnancy is crucial for maternal health and optimal fetal development; however, suboptimal B12 status has been reported in pregnant Canadian women...
  86. Iqbal M, Iqbal K, Tareen A, Parveen S, Mehboobali N, Haider G, et al. Polymorphisms in MTHFR, MS and CBS genes and premature acute myocardial infarction in a Pakistani population. Pak J Pharm Sci. 2016;29:1901-1906 pubmed
    ..Plasma/serum samples of both patients and healthy controls were screened for homocysteine, folate and vitamin B12. One way ANOVA and chi-squared test were used for analysis of data...
  87. Zulfiqar A, Sui Seng X, Duhamel E, Kadri N, Doucet J, Andres E. [What to do before a hypervitaminia B12 in the elderly]. Soins Gerontol. 2017;22:41-43 pubmed publisher
    Hypervitanimia B12 is an early marker of serious pathologies. These include solid neoplasms, malignant blood diseases and acute/chronic hepatopathies...
  88. Tian H, Shimakoshi H, Park G, Kim S, You Y, Hisaeda Y. Photocatalytic function of the B12 complex with the cyclometalated iridium(iii) complex as a photosensitizer under visible light irradiation. Dalton Trans. 2018;47:675-683 pubmed publisher
    ..Transient photoluminescence experiments revealed that the oxidative quenching of the photosensitizer dominated over the reductive quenching pathway. ..
  89. Lima S, Webb C, Deery E, Robinson C, Zedler J. Human Intrinsic Factor Expression for Bioavailable Vitamin B12 Enrichment in Microalgae. Biology (Basel). 2018;7: pubmed publisher
    ..Utilizing IF expression could be an efficient tool to generate B12-enriched microalgae in a controlled manner that is suitable for vegetarians and, potentially, more bioavailable for humans. ..
  90. Spence J. Homocysteine lowering for stroke prevention: Unravelling the complexity of the evidence. Int J Stroke. 2016;11:744-7 pubmed publisher
    ..Stroke Prevention trial were negative included folate fortification in North America, provision of injections of B12 to patients with low baseline serum B12, and as it turns out, harm from cyanide in cyanocobalamin among ..
  91. Caramaschi D, Sharp G, Nohr E, Berryman K, Lewis S, Davey Smith G, et al. Exploring a causal role of DNA methylation in the relationship between maternal vitamin B12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study. Hum Mol Genet. 2017;26:3001-3013 pubmed publisher
    An adequate intake of vitamin B12 during pregnancy plays an important role in offspring neurodevelopment, potentially via epigenetic processes...
  92. Sanchez H, Hossain M, Lera L, Hirsch S, Albala C, Uauy R, et al. High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans. Clin Epigenetics. 2017;9:74 pubmed publisher
    ..We evaluated how availability of dietary factors (folates and vitamin B12) involved in one-carbon metabolism may contribute to DNA methylation changes of cancer-related genes in human ..