Gene Symbol: TNF-alpha
Description: tumor necrosis factor
Alias: DIF, TNF-alpha, TNFA, TNFSF2, APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Species: human

Top Publications

  1. doi TNF-alpha induces two distinct caspase-8 activation pathways
    Lai Wang
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 133:693-703. 2008
  2. ncbi The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
  3. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
  4. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
  5. pmc TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    Adam P Gregory
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nature 488:508-11. 2012
  6. doi The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
    Aya Shiraki
    Saga University Faculty of Medicine Department of Cardiovascular and Renal Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Atherosclerosis 221:375-82. 2012
  7. pmc Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population
    Hivana Patricia Melo Barbosa
    Laboratory of Immunogenetics, Federal University of Para, 66075 110 Belem, Brazil
    World J Gastroenterol 15:1465-71. 2009
  8. pmc HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells
    Elena Martinelli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3396-401. 2007
  9. ncbi Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population
    Wanli Lu
    Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing 100036, People s Republic of China
    Carcinogenesis 26:631-6. 2005
  10. pmc Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha
    Sinead M Flannery
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 286:23688-97. 2011

Detail Information

Publications322 found, 100 shown here

  1. doi TNF-alpha induces two distinct caspase-8 activation pathways
    Lai Wang
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 133:693-703. 2008
    ..These findings revealed that TNF-alpha is able to induce apoptosis via two distinct caspase-8 activation pathways that are differentially regulated by cIAP1/2 and c-FLIP...
  2. ncbi The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
    ..However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF-induced cell death and NF-kappa B activation are distinct...
  3. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
    ..The rTACE provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of TNF-alpha production...
  4. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated...
  5. pmc TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    Adam P Gregory
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nature 488:508-11. 2012
    ..Hence, our study demonstrates that clinical practice can be informed by comparing GWAS across common autoimmune diseases and by investigating the functional consequences of the disease-associated genetic variation...
  6. doi The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
    Aya Shiraki
    Saga University Faculty of Medicine Department of Cardiovascular and Renal Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Atherosclerosis 221:375-82. 2012
    ..However, the effects upon endothelial cells and the mechanisms involved are not fully understood. We assessed the hypothesis that GLP-1 has protective effects against inflammation and oxidative stress on human endothelial cells...
  7. pmc Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population
    Hivana Patricia Melo Barbosa
    Laboratory of Immunogenetics, Federal University of Para, 66075 110 Belem, Brazil
    World J Gastroenterol 15:1465-71. 2009
    ..To study the association between Interleukin-1 (IL-1) and tumor necrosis factor (TNF)-alpha polymorphisms, infection by Helicobacter pylori (H pylori) and the development of gastrointestinal diseases...
  8. pmc HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells
    Elena Martinelli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3396-401. 2007
  9. ncbi Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population
    Wanli Lu
    Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing 100036, People s Republic of China
    Carcinogenesis 26:631-6. 2005 assess the association between genetic polymorphisms in interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor alpha (TNFalpha), which are involved in H.pylori infection, and risk of gastric cancer...
  10. pmc Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha
    Sinead M Flannery
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 286:23688-97. 2011
    ..Collectively, these data demonstrate for the first time an essential role for IRAK-2 in primary human cells for both transcriptional and post-transcriptional TLR responses...
  11. pmc Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 199:569-75. 2009
    ..Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms...
  12. pmc Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
    BMC Cancer 11:130. 2011
    ..In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and to identify the possible implications of these factors to disease course...
  13. ncbi Expression of 8-oxoguanine DNA glycosylase 1 (OGG1) and the level of p53 and TNF-αlpha proteins in peripheral lymphocytes of patients with Alzheimer's disease
    Mateusz Dezor
    Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poland
    Folia Neuropathol 49:123-31. 2011
    ..It is possible that OGG1 and p53 and TNF-α proteins together or separately may be involved in pathogenesis of AD by repair of oxidative DNA damage and/or apoptosis...
  14. ncbi Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors
    S Muller
    German Diabetes Clinic, German Diabetes Research Institute at the University of Düsseldorf, Dusseldorf, Germany
    Diabetologia 45:805-12. 2002
    ..A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance...
  15. ncbi IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
    H Wesche
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:19403-10. 1999
    ..The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family...
  16. ncbi c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    J Biol Chem 278:9944-52. 2003
    ..These two pathways converge at IKKbeta and go on to activate NF-kappaB, via serine phosphorylation and degradation of IkappaB-alpha, and, finally, to initiate ICAM-1 expression...
  17. pmc Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation
    Yihui Fan
    Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
    J Biol Chem 285:5347-60. 2010
    Transforming growth factor-beta-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor alpha (TNFalpha)- and interleukin-1beta (IL-1beta)-induced IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) and c-Jun N-..
  18. pmc Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling
    Jason S Rockel
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A5C1, Canada
    Arthritis Res Ther 11:R8. 2009
    ..TNFalpha activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; however, the overall functional relevance of MEK/ERK to TNFalpha-regulated gene expression in chondrocytes is unknown...
  19. ncbi Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea
    Ja Young Lee
    Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University Medical Center, 445, Kildong, Kangdong gu, Seoul 134 701, South Korea
    Cancer Lett 225:207-14. 2005
    ..pylori infection status, location of GC, and histologic type of GC. In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea...
  20. doi Systemic cytokine response in patients with community-acquired pneumonia
    H Endeman
    Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Eur Respir J 37:1431-8. 2011
    ..IL-1RA, IL-6, IL-8 and IL-10 are acute phase proteins, independent of genotype. Their levels are influenced by the nature of the causative microorganism and the start of corticosteroids therapy...
  21. ncbi Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation
    Mohamed Hassan
    Department of Dermatology, Faculty of Medicine, University of Duesseldorf, Mooren Strasse 5, 40225 Duesseldorf, Germany
    Cell Signal 19:301-11. 2007
    ..patients is associated with the production of serum and interhepatic inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha)...
  22. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
    ..and CYP1A1, the "proapoptotic" polymorphism in BCL2, and the five "high-production" polymorphisms in tumor necrosis factor alpha (TNF-alpha) using PCR-based genotyping assays...
  23. ncbi Cytokine gene polymorphism in sympathetic ophthalmia
    Denize Atan
    Academic Unit of Ophthalmology, Clinical Sciences South Bristol, Bristol Eye Hospital, UK
    Invest Ophthalmol Vis Sci 46:4245-50. 2005
    ..The purpose of this study was to determine whether polymorphisms in the cytokine genes are important markers for disease severity and outcome in patients with SO...
  24. doi IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes
    Arnaud Hot
    Department of Clinical Immunology and Rheumatology and Immunogenomics and Inflammation Research Unit, Hopital Edouard Herriot, University of Lyon 1, Lyon, France
    Ann Rheum Dis 71:1393-401. 2012
    ..To examine the effect of interleukin-17 (IL-17) on rheumatoid arthritis (RA) synoviocyte migration and invasiveness...
  25. pmc TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis
    Youde Jiang
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Cell Signal 24:1086-92. 2012
    ..Resolution of the hyperglycemia-induced TNFα levels in retinal endothelial cells may prevent apoptosis through disinhibition of insulin receptor signaling...
  26. doi Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles
    Danielle B Peterson
    Department of Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, WI 53226, USA
    Proteomics 8:2430-46. 2008
    ..These observations provide fundamental insight into the mechanisms regulating the production of these particles and their physiological role in numerous diseases...
  27. pmc Follicular dendritic cells and human immunodeficiency virus type 1 transcription in CD4+ T cells
    Tyler C Thacker
    Department of Chemistry and Biochemistry, Room C 211A BNSN, Brigham Young University, Provo, UT 84602, USA
    J Virol 83:150-8. 2009
    ..FDCs produced soluble tumor necrosis factor alpha (TNF-alpha) ex vivo, and the addition of a blocking soluble TNF receptor ablated FDC-mediated HIV ..
  28. doi PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, Institute of Health Sciences, School of Medicine, and Biomedical Center BK21, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Atherosclerosis 213:115-21. 2010
    ..It is concluded that PTEN selectively inhibits expression of VCAM-1 but not ICAM-1 through modulation of PI3K/Akt/GSK-3β/GATA-6 signaling cascade in TNF-α-treated ECs...
  29. doi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  30. doi TIMP-1 interaction with αvβ3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-α-induced apoptosis
    Ioanna Tsagaraki
    Institute of Biology, National Center for Scientific Research Demokritos, 15310 Agia Paraskevi, Athens, Greece
    Cell Tissue Res 342:87-96. 2010
    ..The biological role of this interaction was revealed by the use of echistatin, an antagonist of αvβ3 integrin. In the presence of echistatin, decreased protection against apoptosis by recombinant TIMP-1 was observed...
  31. pmc Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells
    Mostafa A Gabr
    Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Orthop Res 29:1-7. 2011
    ..IL-17 may be an important regulator of inflammation in the IVD pathologies...
  32. ncbi The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10
    Ana Carolina F Motta
    Division of Dermatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz Dent J 21:158-64. 2010
    ..05). These results suggest that oral infection could be involved as a maintenance factor in the pathogenesis of leprosy reactional episodes...
  33. ncbi The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome
    Silvia Sookoian
    Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Hypertens 18:1271-5. 2005
    ..We investigated the possible contribution of the G-308A TNF-alpha mutant to explain variables of the metabolic syndrome...
  34. doi Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1
    Maria J Smolinska
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Oxford University, London W6 8LH, United Kingdom
    J Immunol 187:6043-51. 2011
    ..These data highlight the importance of Hck as an active component in LPS-induced TLR signaling and suggest the possibility of targeting this kinase for the alleviation of excessive inflammation...
  35. doi Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-α
    Rebecca K Studer
    VA Pittsburgh, Pittsburgh, PA, USA
    Spine (Phila Pa 1976) 36:593-9. 2011
    ..CONCLUSION.: The results suggest maneuvers to diminish IL-6 production in the disc could provide some protection against the adverse effects of IL-1 and TNF-α, thus, helping preserve disc composition, structure, and function...
  36. ncbi Association of TNF-alpha polymorphism with susceptibility to and severity of non-small cell lung cancer
    Chuen Ming Shih
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
    Lung Cancer 52:15-20. 2006
  37. ncbi Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases
    Thorsten Hagemann
    Department of Haematology Oncology, Georg August University, Gottingen, Germany
    Carcinogenesis 25:1543-9. 2004
    ..In summary, we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to TNF-alpha dependent MMP induction in the macrophages...
  38. pmc Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells
    Paul D Upton
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge CB2 2QQ, UK
    J Biol Chem 284:15794-804. 2009
    ..This differential signaling may contribute to the contrasting pathologies of hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension...
  39. doi Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways
    Fabrizio Montecucco
    Laboratory of Phagocyte Physiopathology, First Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa Medical School, Genoa, Italy
    Cell Signal 20:557-68. 2008
    ..Although highly speculative, ERK 1/2 p44 may represent a selective target for the pharmacologic manipulation of neutrophil-mediated adverse activities in TNF-alpha-mediated inflammatory states...
  40. pmc S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
    Jin Zhang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 283:35375-82. 2008
    ..We present a new mechanism for TNF-alpha to induce insulin resistance that involves activation of S6K by an IKK2-dependent pathway. S6K directly phosphorylates IRS-1 on multiple serine residues to inhibit insulin signaling...
  41. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  42. ncbi TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients
    Sandra A Drigo
    Heart Institute InCor, School of Medicine, University of Sao Paulo, Av Dr Eneas de Carvalho Aguiar 44, Bloco 2, 9 andar, CEP 05403 001 São Paulo, Brazil
    Microbes Infect 8:598-603. 2006
    ..We typed the TNFa microsatellite and the -308 TNF promoter polymorphism and then analyzed the survival curves of 42 patients with ..
  43. ncbi The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B
    S Bour
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 276:15920-8. 2001
    ..However, in the presence of Vpu, this HIV-mediated NF-kappaB activation was markedly reduced. These results suggest that Vpu modulates both virus- and cytokine-induced activation of NF-kappaB in HIV-1-infected cells...
  44. pmc TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e12479. 2010
    ..This regulation coincides with elevated levels of muscle derived TNFalpha that is also under IKKbeta and NF-kappaB control...
  45. doi Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population
    Silvia Jiménez-Morales
    Genomic of Complex Diseases Laboratory, Instituto Nacional de Medicina Genomica, SS, Mexico City, Mexico
    Hum Immunol 70:251-6. 2009
    ..89, p = 0.004). These results support the concept that the TNF-alpha gene is a genetic risk factor for asthma, SLE, and JRA in the pediatric Mexican population...
  46. doi Moraxella catarrhalis lipooligosaccharide selectively upregulates ICAM-1 expression on human monocytes and stimulates adjacent naïve monocytes to produce TNF-alpha through cellular cross-talk
    Hang Xie
    Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Cell Microbiol 10:1453-67. 2008
    ..These results suggest that M. catarrhalis LOS could induce excessive middle ear inflammation through a cellular cross-talk mechanism during OME...
  47. ncbi IL1RN polymorphic gene and cagA-positive status independently increase the risk of noncardia gastric carcinoma
    Gifone Aguiar Rocha
    Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Int J Cancer 115:678-83. 2005
    ..Our aim was to evaluate whether IL-1 gene cluster and tumor necrosis factor-alpha (TNFA)-307 polymorphisms, as well as cagA-positive status, are associated with gastric carcinoma in a non-Caucasian ..
  48. pmc Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites
    Stephen J Wort
    Department of Critical Care, National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom
    J Biol Chem 284:24297-305. 2009
    ..synergistic induction of preproET-1 message RNA and release of mature peptide by a combination of tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) in primary human pulmonary artery smooth muscle cells...
  49. ncbi Autoimmunity and tuberculosis. Opposite association with TNF polymorphism
    Paula A Correa
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia
    J Rheumatol 32:219-24. 2005
  50. pmc Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicity
    Lara Buscemi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Neurobiol Dis 26:661-70. 2007
  51. pmc Association of tumor necrosis factor alpha gene polymorphism G-308A with pseudoexfoliative glaucoma in the Pakistani population
    Muhammad Imran Khan
    Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 15:2861-7. 2009
    The purpose of the present study was to determine the role of the tumor necrosis factor alpha (TNF-alpha) gene polymorphism G-308A and total serum immunoglobulin E (TsIgE) levels in the onset of pseudoexfoliation glaucoma (PEXG) in ..
  52. ncbi Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population
    P Kummee
    Inter Department of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand
    J Viral Hepat 14:841-8. 2007
    ..Additional study is needed to validate these finding and to further explore the genetic pathogenesis of HBV infection...
  53. ncbi The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
    Arthritis Rheum 50:2750-6. 2004
    ..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...
  54. doi Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle
    Miranda D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia
    Clin Exp Pharmacol Physiol 35:846-51. 2008
  55. ncbi Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes
    Seong Su Nah
    Division of Allergy and Rheumatology, Department of Internal Medicine, College of Medicine, University of Ulsan, Asan Medical Center, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    FEBS Lett 581:1928-32. 2007
    ..In conclusion, accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha...
  56. doi Association of TNFA -308 G/A and TNFRI +36 A/G gene polymorphisms with glaucoma
    Mohammad Reza Razeghinejad
    Department of Ophthalmology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
    Ophthalmic Res 42:118-24. 2009
    ..Therefore, the association of single nucleotide polymorphisms in the TNFRI gene and the promoter region of the TNFA gene with glaucoma susceptibility was investigated in the present study.
  57. ncbi Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways
    Xianghuai Lu
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Decatur, Georgia 30033, USA
    J Biol Chem 281:6297-306. 2006
    ..The inhibitory effect of TNF on Osx expression may decrease OB differentiation in arthritis and osteoporosis...
  58. ncbi Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of association with health and disease
    Maqsood M Elahi
    Department of Human Sciences, Human Genetics Laboratory, Loughborough University, Leicestershire, UK
    Biochim Biophys Acta 1792:163-72. 2009
    ..This review discusses the genetics of the TNF-alpha -308 polymorphism in selected major diseases and evaluates its common role in health and disease...
  59. ncbi Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    Biochem Biophys Res Commun 335:1254-63. 2005
    ..Our data suggest that adiponectin constant presence in the circulation in high levels (in lean subjects) renders macrophages resistant to pro-inflammatory stimuli, including its own...
  60. doi A meta-analysis on the association between three promoter variants of TNF-α and Crohn's disease
    Cui Xie
    Laboratory of Disorder Genes and Department of Pharmacology, College of Pharmacy, Chongqing Medical University, 1 Yi Xue Yuan Road, P O Box 380, Chongqing 400016, People s Republic of China
    Mol Biol Rep 39:1575-83. 2012
    ..76) and GG (OR 0.92, 95% CI 0.70-1.21, P = 0.55) genotypes were associated with CD susceptibility, respectively. Our meta-analysis demonstrates that three promoter polymorphisms of TNF-α above may not confer susceptibility to CD...
  61. doi Essential role of NF-κB and AP-1 transcription factors in TNF-α-induced TSLP expression in human airway smooth muscle cells
    Naresh Singh Redhu
    Dept of Immunology, Faculty of Medicine, Univ of Manitoba, Winnipeg, Canada
    Am J Physiol Lung Cell Mol Physiol 300:L479-85. 2011
    ..05; n = 3) in HASM. Collectively, our data suggest a novel important biological role for NF-κB pathway in TNF-α-induced TSLP expression in HASM and recommend this as a prime target for anti-inflammatory drugs...
  62. ncbi Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes
    Yumie Takeshita
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Eur J Pharmacol 579:426-32. 2008
    ..Selective angiotensin AT(1) receptor antagonists inhibit both TNF-alpha- and angiotensin II-induced PAI-1 production in hepatocytes, suggesting a cross talk between both systems...
  63. pmc HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2
    Giorgio Mangino
    Department of Biology, University Roma Tre, Rome, Italy
    PLoS ONE 6:e22982. 2011
  64. doi Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes
    Maja Mustapic
    Rudjer Boskovic Institute, Zagreb, Croatia
    Metab Brain Dis 27:507-12. 2012
    ..Our data confirm the association between the ApoE4 allele and AD, and point out the E2 allele of ApoE gene as the possible risk factor for T2D...
  65. doi Tumor necrosis factor alpha gene polymorphism is associated with the outcome of trauma patients in Chinese Han population
    Zhao Xia Duan
    Department 6 of Research Institute of Surgery, Daping Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China
    J Trauma 70:954-8. 2011
    ..The purpose of this article was to research the clinical relevance of the TNF gene polymorphism in patients with major trauma...
  66. ncbi Association of TNF-alpha promoter polymorphisms with the outcomes of hepatitis B virus infection in Chinese Han population
    T Du
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
    J Viral Hepat 13:618-24. 2006
    ..0001, P = 0.0004). In conclusion, TNF-alpha promoter polymorphisms are independently associated with different outcomes of HBV infection...
  67. doi Cytokine polymorphism in noninfectious uveitis
    Denize Atan
    Clinical Sciences at South Bristol, Bristol Eye Hospital, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4133-42. 2010
    ..b>TNFA and IL10 are strong candidate genes, given the influence of these cytokines on inflammation, immune tolerance, and ..
  68. doi Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis
    Oliver Teuffel
    the Division of Haematology Oncology, Hospital for Sick Children, Toronto, Canada
    Crit Care Med 38:276-82. 2010
    ..We conducted a systematic review and meta-analysis to determine whether the TNF-alpha -308 A/G polymorphism TNF2 (G/A or A/A) confers susceptibility to sepsis or is associated with increased risk of death from sepsis...
  69. pmc c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
    Eugene Varfolomeev
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 283:24295-9. 2008
    ..Therefore, c-IAP1 and c-IAP2 are required for TNFalpha-stimulated RIP1 ubiquitination and NF-kappaB activation...
  70. pmc Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder
    N Konuk
    Department of Psychiatry, Faculty of Medicine, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey
    Mediators Inflamm 2007:65704. 2007
    ..The aim of this study was to evaluate the plasma levels of the cytokines; tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in OCD patients...
  71. ncbi Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion
    Marina G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 13:161-72. 2002
    ..In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion...
  72. ncbi [The -308 and -238 Polymorphisms of the TNF-alpha Promoter Gene in Type 2 Diabetes Mellitus.]
    Hye Ryoun Kim
    Department of Laboratory Medicine, Chung Ang University College of Medicine, Seoul, Korea
    Korean J Lab Med 26:58-63. 2006
  73. ncbi Association of-238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection
    Hong quan Li
    Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, China
    Biomed Environ Sci 19:133-6. 2006
    ..To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-alpha) gene promoter were associated with outcomes of hepatitis B virus infection...
  74. ncbi Mapping the HLA association in Behçet's disease: a role for tumor necrosis factor polymorphisms?
    Tariq Ahmad
    Gastroenterology Unit, Gibson Laboratories, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Arthritis Rheum 48:807-13. 2003
    Experimental evidence suggests that inappropriate regulation of tumor necrosis factor alpha (TNF alpha) may play a role in the pathogenesis of Behçet's disease (BD)...
  75. ncbi Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men
    T Ishii
    Department of Internal Medicine and Health Center, Keio University School of Medicine, Tokyo, Japan
    Metabolism 49:1616-8. 2000
    In obese subjects, the levels of tumor necrosis factor alpha (TNF-alpha) expression and protein synthesis in adipocytes are increased...
  76. doi Tumor necrosis factor-alpha-308A allele may have a protective effect for chronic hepatitis B virus infection in Mongoloid populations
    Ming Hua Zheng
    Department of Infection and Liver Diseases, Liver Research Center, First Affiliated Hospital of Wenzhou Medical College, No 2 Fuxue Lane, Wenzhou, Zhejiang, China
    Int J Infect Dis 14:e580-5. 2010
    ..Previous studies on the tumor necrosis factor-alpha (TNF-alpha)-308 gene promoter polymorphism in chronic hepatitis B virus (HBV) infection have reported conflicting results...
  77. doi Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians
    Reeshu Gupta
    Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    Oral Oncol 44:455-63. 2008
    ..These SNPs may be useful as a marker for high-risk groups among Asian Indians...
  78. doi Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population
    Rym Bouhaha
    Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, 2092 Tunis, Tunisia
    Clin Biochem 43:549-52. 2010
    ..We investigated two genetic markers in pro inflammatory molecules : TNFalpha -308G/A and IL6 -174G/C in order to assess their effect on type 2 diabetes (T2D) and obesity in the Tunisian population...
  79. ncbi Haplotypes in the tumour necrosis factor region and myeloma
    Gareth J Morgan
    Section of Haemato oncology, Institute for Cancer Research, Royal Marsden Hospital, London, UK
    Br J Haematol 129:358-65. 2005
    ..308 and -238 of the 5' promoter region of TNF-alpha gene, and 252 in the LT-alpha gene; and five microsatellites, TNFa, b, c, d and e. Haplotypes were inferred statistically using the phase algorithm...
  80. pmc Association between LTA, TNF and AGER polymorphisms and late diabetic complications
    Eero Lindholm
    Department of Clinical Sciences, University Hospital MAS, Lund University, Lund, Sweden
    PLoS ONE 3:e2546. 2008
    ..The aim of our study was therefore to explore whether polymorphisms (TNF -308 G-->A, LTA T60N C-->A and AGER -374 T-->A) in these genes alone or together (as haplotypes) increased the risk for diabetic complications...
  81. ncbi Proinflammatory cytokines Il-6 and TNF-α and the development of inflammation in obese subjects
    Katarzyna Popko
    Department of Laboratory Diagnostics, Warsaw Medical University, Warsaw, Poland
    Eur J Med Res 15:120-2. 2010
    ..Both cytokines are the main factors responsible for the induction of acute phase proteins production (e.g., CRP) and to inflammatory state...
  82. ncbi Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
    Chee Kwee Ea
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 22:245-57. 2006
    ..protein kinase 1 (RIP1) is essential for the activation of nuclear factor kappaB (NF-kappaB) by tumor necrosis factor alpha (TNFalpha)...
  83. ncbi Allele 2 of the interleukin-1 receptor antagonist gene is associated with early gastric cancer
    Jurgen Glas
    Medizinische Poliklinik, Chirurgische Klinik und Poliklinik, Klinikum der Universitat Munchen, Standort Innenstadt, Germany
    J Clin Oncol 22:4746-52. 2004
    ..In early-stage gastric cancer, which we defined as adenocarcinoma confined to the mucosa or submucosa (stage T1), the role of host genetic susceptibility remains to be determined...
  84. doi TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages
    Federica Alciato
    Clinical Immunology, Department of Clinical and Experimental Medicine, Universita del Piemonte Orientale A Avogadro, Novara, Italy
    J Leukoc Biol 87:869-75. 2010
    ..Therefore, GAS6 modulates macrophage cytokine secretion, triggering an "anti-inflammatory pathway" involving PI3K/Akt/GSK3 beta and NF-kappaB...
  85. ncbi Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic fever
    Onder Ergonul
    Infectious Diseases and Clinical Microbiology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
    J Infect Dis 193:941-4. 2006
    ..In conclusion, these findings demonstrate that proinflammatory cytokines play a major role in the mortality of patients with CCHF...
  86. doi Lack of association between TNF 238 G/A polymorphism and type 2 diabetes: a meta-analysis
    Rennan Feng
    Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, Harbin, People s Republic of China
    Acta Diabetol 46:339-43. 2009
    ..18 (0.92-1.51) and 1.13 (0.62-2.04), respectively. This first meta-analysis of data from the current and published studies did not detect any association between the polymorphism of TNF 238 G/A and risk for T2D...
  87. ncbi NRAMP1 and TNF-alpha polymorphisms and susceptibility to tuberculosis in Thais
    Sasijit Vejbaesya
    Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Respirology 12:202-6. 2007
    ..However, the results are inconsistent. This study aimed to determine whether NRAMP1 and TNF-alpha variants are associated with tuberculosis in Thais...
  88. ncbi TNF and TNF receptor polymorphisms in Korean Behcet's disease patients
    Eun Bong Lee
    Department of Internal Medicine, Clinical Research Institute, Human Genome Research Institute, Medical Research Center, Seoul, South Korea
    Hum Immunol 64:614-20. 2003
    ..In this study, we investigated genetic polymorphisms of TNF alpha -308 G/A, TNF beta +252 G/A, and TNFR2 196 R/M in 94 Korean BD patients and age- and sex-matched healthy ..
  89. ncbi TNF-alpha, TGF-beta1, IL-10, IL-6, gene polymorphisms in latent autoimmune diabetes of adults (LADA) and type 2 diabetes mellitus
    A Tsiavou
    Onassis Cardiac Surgery Center, Molecular Immunopathology and Histocompatibility Laboratory, 356 Sygrou Avenue, Athens 17674, Greece
    J Clin Immunol 24:591-9. 2004
  90. ncbi TNF-alpha promoter single nucleotide polymorphisms in gastroenteropancreatic neuroendocrine tumors
    Maja Berković
    Department of Endocrinology, Diabetes and Metabolism, University Hospital Sestre Milosrdnice, Zagreb, Croatia
    Neuroendocrinology 84:346-52. 2006
    ..The results suggest the putative role of TNF-alpha -1031 polymorphism in the development of GEP-NET...
  91. ncbi A functional promotor polymorphism of TNF-alpha is associated with primary gastric B-Cell lymphoma
    Stephan Hellmig
    Department of General Internal Medicine, University Clinics of Schleswig Holstein, Campus Kiel, Germany
    Am J Gastroenterol 100:2644-9. 2005
    ..We investigated four functional promotor polymorphisms in the TNF-alpha gene for association with the development of primary gastric B-cell lymphoma...
  92. ncbi Profound bias in interferon-gamma and interleukin-6 allele frequencies in western Kenya, where severe malarial anemia is common in children
    Ian S Gourley
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Infect Dis 186:1007-12. 2002
    ..IFN-gamma and IL-6 genotypes may play roles in the development of severe malaria and could contribute to the relative frequency of severe malarial anemia or cerebral malaria in exposed populations...
  93. ncbi Tumor necrosis factor-alpha promoter polymorphism is associated with susceptibility to oral squamous cell carcinoma
    Chung Ji Liu
    Department of Oral and Maxillofacial Surgery, Taipei Mackay Memorial Hospital, Taipei, Taiwan
    J Oral Pathol Med 34:608-12. 2005
    ..Polymorphism of the TNF-alpha gene has been intensively studied as a potential determinant of susceptibility to numerous cancers...
  94. ncbi Lack of association of tumor necrosis factor-alpha polymorphisms with Chagas disease in Brazilian patients
    Sandra A Drigo
    Heart Institute InCor, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Immunol Lett 108:109-11. 2007
    ..We analyzed the TNFa microsatellite and the -308 TNF promoter polymorphisms, in 166 CCC compared to 80 ASY geographically and age-..
  95. ncbi Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia
    Klára Sochorová
    Institute of Immunology, Charles University, 2nd Medical School, Prague, Czech Republic
    Blood 109:2553-6. 2007
    ..These findings may provide an explanation for the susceptibility to enteroviral infections in XLA patients...
  96. ncbi Comparison of serum concentrations of C-reactive protein, TNF-alpha, and interleukin 6 between elderly Korean women with normal and impaired glucose tolerance
    K M Choi
    Department of Internal Medicine, Korea University Guro Hospital, 80 Guro dong, Guro Gu, Seoul 152 050, South Korea
    Diabetes Res Clin Pract 64:99-106. 2004
    ..was performed to compare concentrations of pro-inflammatory cytokines, such as interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) as well as acute-phase protein, such as C-reactive protein (CRP) between subjects with ..
  97. ncbi Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence
    F Perri
    Department and Research Laboratory of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, 71013 San Giovanni Rotondo, Italy
    Cytokine 30:293-302. 2005
    ..An epistatic interrelationship between IL-1beta -511 and IL-1RN confers protection against gastric cancer in low-risk Italian population...
  98. ncbi No allelic variant associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease
    M A Garcia-Gonzalez
    Unidad Mixta de Investigación and Department of Gastroenterology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Int J Immunogenet 32:299-306. 2005 investigate possible allelic variant associations of several functional polymorphisms in the IL-1B, IL-1RN, TNFA, and LTA genes in the susceptibility to duodenal ulcer...
  99. ncbi Promoter polymorphisms of tumor necrosis factor-alpha are associated with risk of gastric mucosa-associated lymphoid tissue lymphoma
    Ming Shiang Wu
    Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Int J Cancer 110:695-700. 2004
    ..The differences in genetic background as well as divergent clinicopathologic features between GAC and maltoma support the notion that fundamental mechanistic differences exist in these 2 well-defined H. pylori-related malignancies...
  100. ncbi Gene polymorphisms of TNF-alpha(-308), IL-10(-1082), IL-6(-174), and IL-1Ra(VNTR) related to susceptibility and severity of rheumatic heart disease
    A Settin
    Pediatric Genetics Unit, Mansoura University Children Hospital, Mansoura, Egypt
    Pediatr Cardiol 28:363-71. 2007
  101. ncbi Interleukin -1beta (IL-1 beta), interleukin 6 (IL-6) and tumor necrosis factor (TNF) in plasma and pleural fluid of pneumonia, lung cancer and tuberculous pleuritis
    G Ilonidis
    Fourth Internal Medicine Clinic, Hippokration Hospital, Aristotle University of Thessaloniki, Greece
    J Biol Regul Homeost Agents 20:41-6. 2006
    ..33, 49.94, 21.27 pg/ml and 14, 56.59, 23.58 pg/ml. In conclusion, IL-1beta and IL-6 were found increased in plasma and tuberculous pleural fluid, indicating an inflammatory status...

Research Grants75

    ALBERT BALDWIN JR; Fiscal Year: 2003
    b>Tumor necrosis factor alpha (TNFalpha) is a proinflammatory cytokine produced by activated macrophages as well as by several other cell types...
  2. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..An understanding of the fetal mechanisms associated with sex differences in MOD will have etiologic imolications and imoortance for the development of sex-specific treatments and prevention of MOD. ..
    Frank B Hu; Fiscal Year: 2013
  4. PARP-1 in Juvenile Idiopathic Arthritis-associated IL-10 Promoter Polymorphisms
    Jianguo Liu; Fiscal Year: 2011
  5. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..abstract_text> ..
  6. Pathogenesis of Postoperative Cognitive Dysfunction
    Zhongcong Xie; Fiscal Year: 2013
    ..This proposal aims to investigate an understudied topic in an innovative system by testing novel hypotheses. Our efforts would ultimately lead to safer surgical care and better post-operative outcomes for senior patients. ..
  7. Regulation of IL-6 mediated inflammation and tissue destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2013
    ..Successful completion of this study will lay the foundation for testing EGCG as a treatment option for RA and other inflammatory diseases. ..
  8. TNF Alpha in PKC Epsilon Signaling to Carcinogenesis
    Ajit K Verma; Fiscal Year: 2013
    ..development of squamous cell carcinoma (SCC) via increased expression of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF1) and granulocyte colony-stimulating factor (G-CSF) which may directly promote the proliferation ..
  9. Can Lifestyle Modify Fatigue in Breast Cancer Survivors?
    Wendy Y Chen; Fiscal Year: 2011
  10. The Role of Mast Cells in the Pathophysiology of Intracranial Aneurysm
    Tomoki Hashimoto; Fiscal Year: 2013
    ..This study will be a basis for future studies to test pharmacological therapies that target mast cells or mast cells-derived cytokines for the prevention of aneurysmal subarachnoid hemorrhage. ..
  11. Persistent COMT-dependent Pain: Role of beta-adrenergic Receptors
    ANDREA G NACKLEY NEELY; Fiscal Year: 2013
    ..g., beta2- and beta3ARs) for development of effective therapies for patients with persistent pain conditions.]] ..
  12. ADAM17 in pancreatic cancer and pancreatitis
    Howard C Crawford; Fiscal Year: 2013
    ..In Aim 3, we will use pharmacological inhibition of ADAM17 released cytokines tumor necrosis factor alpha (TNFa) and interleukin 6 receptor (IL6R) to test for their influence on the etiology of pancreatic ..
  13. Genetic Regulation of Indoleamine-2,3-dioxygenase and Psychiatric Complications o
    Gregory F Oxenkrug; Fiscal Year: 2010
    ..HEALTH RELEVANCE: The proposed study aims to investigate whether analysis of cytokine gene polymorphisms might help to identify hepatitis C patients with high risk of developing psychiatric complications in response to IFN-alpha therapy ..
  14. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2010
    ..If successful, these studies will lead to development of novel adjunct therapies for improving clinical pain control by controlling the negative consequences of opioid-induced glial activation. ..
  15. The role of the inflammatory response in bone and cartilage changes following non
    ..During the mentored period I will successfully transition from the mentored stage of my career to an independent investigator. ..
  16. 3D Culture of Adipose Tissue for Screening Obesity-related Drugs
    Kacey G Marra; Fiscal Year: 2012
  17. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (TNF1) from dorsal root ganglion (DRG) neuron;and 2) activate glia to release TNF1...
  18. Impact of Ambient Ultrafine Particle Exposures on Alzheimer's Disease Progression
    MICHAEL KERRY O'BANION; Fiscal Year: 2013
    ..The findings will have profound implications for public health policy and will enable the development of therapeutic interventions for this debilitating and costly disease. ..
  19. Interactions among Depressive Symptoms and Genetic Influences on Cardiac Outcomes
    Lorraine Q Frazier; Fiscal Year: 2011
    ..Inflammatory proteins and genes include: Interleukin (IL) 6, C-reactive protein (CRP), Tumor Necrosis Factor Alpha (TNFa), E-Selectin (SELE) and Monocyte Chemoattractant Protein-1 (MCP-1)...
  20. Phase III infliximab for primary treatment of Kawasaki disease IND 11046 6/27/200
    Jane C Burns; Fiscal Year: 2012
    ..Levels of the pro-inflammatory cytokine tumor necrosis factor a (TNFa) are elevated during acute KD and levels are highest in children in whom coronary artery aneurysms subsequently ..
  21. Atlantic Coast Consortium for Asthma (ACC-A) AsthmaNet Clinical Site
    Stephen P Peters; Fiscal Year: 2013
    ..Companion protocols will examine corticosteroid resistance (RASS) and a possible genetic mechanism for resistance (IMMOST) in adults, and the efficacy of inhaled S-nitrosoglutathione (N30-201) (SNORT) in children. ..
  22. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012 fatty acids, serum total and free testosterone and IGF-1), and cytokines (c-reactive protein, tumor necrosis factor alpha and IL-6 as inflammatory biomarkers) after 16 weeks of training+Tp and detraining...
  23. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..The proposed studies can potentially lead to an enhanced understanding of the mechanisms of ACD, and therefore to more effective therapy. ..
  24. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
  25. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    ..Understanding this mechanism will allow us to find new medications that stimulate new bone formation and regeneration of tissue in veterans who suffer from arthritis, aging, and menopause associated fractures. ..
  26. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ..early inflammatory response to radiation damage) of osteoclasts via the cytokines tumor necrosis factor-alpha (TNFa) and interleukin-1 (IL-1)...
  27. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..Extensive work, including our Preliminary Studies, suggests that inhibition of neutral ceramidase may provide a new therapy for these diseases. The proposed studies will provide the first test of this hypothesis. ..
  28. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
  29. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..P-gp at the brain endothelial cell is inhibited by lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF)...
  30. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..endothelial growth factor (VEGF), soluble Interleukin-2 receptor (slL2r), lnterleukein-12 (ILI 2), and tumor necrosis factor alpha (TNFa) in the post transplant period and correlate the results with the event-free survival (EFS) and ..
  31. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
  32. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2013
    ..The major problem to be investigated in this proposal is the mechanism(s) for this dysregulated cytokine metabolism, and our overall goal is the development of novel therapeutic interventions. ..
    DAVID ANTONETTI; Fiscal Year: 2013
    ..Further, the proposal will explore the link between vascular permeability and angiogenesis and the role of the tight junction protein occludin in endothelial cell growth control. ..
  34. Dichotomous Roles of Thrombin in Acetaminophen Hepatotoxicity
    ROBERT ANDREW ROTH; Fiscal Year: 2013
    ..Elucidating mechanisms by which APAP-induced liver injury progresses is essential for defining novel strategies to prevent liver failure in patients and for the general understanding of the pathogenesis of drug-induced liver injury. ..
  35. Pathogenic Mechanisms of Shiga Toxins
    Vernon L Tesh; Fiscal Year: 2010
    ..An improved understanding of how these toxins cause disease is necessary to formulate effective therapeutic agents to block disease progression. ..
  36. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..Finally, this project provides an opportunity for undergraduates at Boise State University to participate in biomedical research and gain an appreciation of the complex regulatory mechanisms that govern regeneration. ..
  37. Opioidergic System: Its Role(s) in Glaucoma
    Shahid Husain; Fiscal Year: 2013
    ..Outcomes of this project will provide valuable leads in the discovery of more effective therapies that can delay or prevent vision loss associated with neurodegenerative diseases such as glaucoma. 5 ..
  38. Sepsis Outcomes and Aging: Role of Sleep Disruption and the Blood Brain Barrier
    Mark R Opp; Fiscal Year: 2013
  39. Preeclampsia, IUGR and Hypertension: Targets for Treatment
    Joey P Granger; Fiscal Year: 2013
  40. Novel therapies in alcoholic hepatitis University of Louisville
    Craig J McClain; Fiscal Year: 2013
  41. An androgen-regulated cytokine network controls prostate apoptosis
    John J Krolewski; Fiscal Year: 2013
    ..Finally, Aim 3 tests the functional role of FLIP, determining if FLIP down-regulation can cooperate with pro- apoptotic cytokines to induce apoptosis and regression of normal prostate and PrCa in a murine model. ..
  42. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
  43. Epidemiology of Bone Loss in African Men
    Joseph M Zmuda; Fiscal Year: 2013
    ..bone loss with age;4) determine if higher concentrations of pro-inflammatory biomarkers, interleukin-6, tumor necrosis factor alpha and c-reactive protein, are each associated with accelerated loss of trabecular and cortical bone;and 5)..
  44. The involvement of IL-12 and IL-27 in immunity to Mycobacterium tuberculosis
    CORY MICHAEL ROBINSON; Fiscal Year: 2013
    ..We have proposed basic research into host immune responses during infection that could have implications in design of therapeutic strategies and vaccines. ..
  45. Analysis of Coding Variants Associated with Age-Related Phenotypes
    ..The proposed research will further my development as an independent investigator and give me valuable experience in the meaningful application of human genetics tools to aging research. ..
  46. Effect of Antiviral CNS Penetration on CSF/Blood Cytokines and Depression in HIV
    Glenn J Treisman; Fiscal Year: 2013
    ..An insight into changes in CSF/blood pro-inflammatory cytokines associated with the CPE of ART may be helpful in developing HIV treatments that have an additional effect of improving mood. ..
  47. Dietary Inflammatory Index and Risk of Cancer in Women
    FRED KINYUY TABUNG; Fiscal Year: 2013
    ..of systemic inflammation: high-sensitivity C- reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha receptor 2 (TNF[unreadable]- 2) at baseline...
  48. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  49. Shared Decision Making In Pediatric Chronic Conditions: Biologics in IBD and JIA
    Ellen A Lipstein; Fiscal Year: 2013
    ..Lipstein's development into a nationally-recognized independent investigator and leader conducting research that improves the decision making process related to treatments for children with chronic conditions. ..
    Mark J Czaja; Fiscal Year: 2013
    ..The ultimate goal of these investigations is to better understand how hepatocytes are injured and die in order to prevent this process and the development of hepatic failure in human liver diseases. ..
  51. Epigenetic Regulation of Intestinal Inflammation
    LINDSAY T MARJORAM; Fiscal Year: 2013
    ..When crossed to an inflammation-responsive tnfa transgenic reporter line generated for this study, aa51...
  52. Sex Steroid Hormones and Calcitonin Gene-Related Peptide
    Chandrasekhar Yallampalli; Fiscal Year: 2013
  53. Inflammation and Cardiovascular Disease in RA
    Andreas H Hielscher; Fiscal Year: 2013
    ..A successful study would provide preliminary data for a more extensive grant application by a newly formed interdisciplinary team of NIAMS researchers. ..
  54. ADPKD: Understanding mechanisms, Discovering treatments.
    Xiaogang Li; Fiscal Year: 2013
    ..The information from our studies will be likely to open new avenues in the research of ADPKD and establish the foundation for developing effective therapies of the disease. ..
  55. Single-cell analysis of TNF-induced signaling, transcription and fate decisions
    Suzanne Gaudet; Fiscal Year: 2013
    ..These approaches will contribute to understanding the multi-factorial control of TNF-induced cell death and will be broadly applicable to the study of other signal transduction networks. ..
  56. TNF-alpha Regulation of Intestinal Paracellular Transport
    Thomas Y Ma; Fiscal Year: 2013
    ..abstract_text> ..
  57. Genetic predictors of anti-TNF treatment response and infections in IBD
    Ashwin Ananthakrishnan; Fiscal Year: 2013
    ..The methodology developed here will also have applications in other EMR-based cohorts to investigate novel therapeutic agents and disease outcomes. ..
  58. BACE1 regulation and TNFR Type II receptor in Alzheimers disease
    Yong Shen; Fiscal Year: 2013
    ..Thus, elucidating the regulatory mechanisms for BACE1 could identify new potential therapeutic targets and therefore diminish possible side effects that could arise by directly targeting BACE1. ..
  59. Creating a 3D dynamic in vitro model of the tumor microenvironment to characteriz
    LUIS FERNANDO ALONZO; Fiscal Year: 2013
    ..Most importantly, the impact of creating an in vitro 3D metastasis model with perfused human capillary bed could significantly enhance high-throughput anti-metastatic drug screening. ..
  60. Mechanisms of Sleepiness Symptoms in Sleep Apnea and Cardiovascular Disease
    Victoria M Pak; Fiscal Year: 2013
    ..Cardiovascular risk measures [ambulatory blood pressure (ABP) and Pulse-Wave Velocity (PWV)] will also be obtained at this time. We hypothesize that the symptoms of EDS are associated with increased cardiovascular risk measures. ..
  61. Opioid Impact on Trim37-Induced Restriction of HIV
    LAUREN BRITTANY BEACH; Fiscal Year: 2013
    ..Notably, NF-KB is one of the major human transcription factors that transcribes HIV-1;tumor necrosis factor alpha (TNFalpha) and LPS both stimulate NF-KB's binding to DNA...
  62. Complications of Immunosuppression for Eye Diseases
    John H Kempen; Fiscal Year: 2013
    ..Estimation of the relative (cost-) effectiveness of alternative immunosuppressants for ocular inflammation will greatly increase the quality of evidence available to guide rational clinical management. ..
  63. A first-in-class orally active anti-TNF-alpha inhibitor to treat AD
    Marni E Harris-White; Fiscal Year: 2013
  64. Racial Disparities in Breast Cancer and the role of micro-RNAs
    Kaladhar B Reddy; Fiscal Year: 2013
  65. Evaluating a Prediction Tool and Decision Aid for Patients with Crohn's Disease
    COREY SIEGEL; Fiscal Year: 2013
    ..Specifically, it focuses on communicating the best available individualized evidence to patients so that they can make an informed decision based on their expressed treatment preferences. ..
  66. Structural &Functional Studies of TLR/IL-1R Signaling
    Hao Wu; Fiscal Year: 2012
  67. Comparative analysis of information transfer in NF-kapppaB and MAPK pathways
    Andre Levchenko; Fiscal Year: 2013
    ..In this context, we propose to study in detail two signals induced by inflammation in mammalian cells. Through such analyses we anticipate to uncover novel principles and mechanisms by which cells respond to external stimuli. ..
    Paul Terranova; Fiscal Year: 2004
    The objective of this application is to delineate the mechanisms by which tumor necrosis factor alpha (TNF) and in receptor system inhibit gonadotropin-stimulated ovarian granulosa cell estradiol secretion using a mouse model...
    William Sonntag; Fiscal Year: 2000
    ..Preliminary data from this laboratory and others suggest that pro-inflammatory cytokines e.g. tumor necrosis factor alpha (TNFa), actively suppress both signal transduction and growth hormone secretory dynamics...
    David Spriggs; Fiscal Year: 1991
    Donald Miller; Fiscal Year: 2001
    ..Together, the proposed studies will provide a better understanding of the mechanisms involved in TNF-a effects on BBB permeability. ..
    SAMUEL LEIBOVICH; Fiscal Year: 1993
    ..e) The effects of TNF-alpha on wound repair in vivo will be studied, using the implanted polyvinyl (lvalon) sponge and the implanted Gortex micropermeable tubing models...
    PRAVIN SEHGAL; Fiscal Year: 1991
    ..These studies are likely to provide insights important to the use of biological response modifiers such as TNF and IFN-Beta2 in the clinic against neoplastic diseases...
  74. TNF alpha Signaling: Effects on AMPA Receptor Location
    ERIC BEATTIE; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): This proposal will study the tumor necrosis factor alpha (TNF-alpha) signaling cascade and its rapid effects on synaptic activity...
  75. Mechanisms of Reperfusion-induced Endothelial Injury
    Cuihua Zhang; Fiscal Year: 2010