Gene Symbol: TNF-alpha
Description: tumor necrosis factor
Alias: DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F, tumor necrosis factor, APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor ligand 1F, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Species: human
Products:     TNF-alpha

Top Publications

  1. Liu X, Kelm R, Strauch A. Transforming growth factor beta1-mediated activation of the smooth muscle alpha-actin gene in human pulmonary myofibroblasts is inhibited by tumor necrosis factor-alpha via mitogen-activated protein kinase kinase 1-dependent induction of the Egr-1 tr. Mol Biol Cell. 2009;20:2174-85 pubmed publisher
    ..We examined the ability of proinflammatory tumor necrosis factor (TNF)-alpha to antagonize TGFbeta1-mediated human pulmonary myofibroblast differentiation...
  2. Song Z, Song Y, Yin J, Shen Y, Yao C, Sun Z, et al. Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality. PLoS ONE. 2012;7:e46113 pubmed publisher
    b>Tumor necrosis factor (TNF) and TNF receptor superfamily (TNFR)-mediated immune response play an essential role in the pathogenesis of severe sepsis...
  3. Wang Y, Lan J, Yang L, Wang De J, Kuang J. TNF-? and IL-1RA polymorphisms and silicosis susceptibility in Chinese workers exposed to silica particles: a case-control study. Biomed Environ Sci. 2012;25:517-25 pubmed publisher
    ..Further independent studies on the interaction between SNPs and exposure to silica particles with a larger sample size are therefore warranted. ..
  4. Gregory A, Dendrou C, Attfield K, Haghikia A, Xifara D, Butter F, et al. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature. 2012;488:508-511 pubmed publisher
    ..Hence, our study demonstrates that clinical practice can be informed by comparing GWAS across common autoimmune diseases and by investigating the functional consequences of the disease-associated genetic variation. ..
  5. Singh H, Jain M, Sachan R, Mittal B. Association of TNFA (-308G>A) and IL-10 (-819C>T) promoter polymorphisms with risk of cervical cancer. Int J Gynecol Cancer. 2009;19:1190-4 pubmed publisher
    ..Pro and anti-inflammatory cytokines (tumor necrosis factor alpha, TNFA and interleukin, IL-10) are involved in fighting against the tumorigenesis...
  6. Sewell G, Rahman F, Levine A, Jostins L, Smith P, Walker A, et al. Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci. Inflamm Bowel Dis. 2012;18:2120-7 pubmed publisher
    ..genome-wide association study (GWAS) susceptibility loci, disease phenotype, and therapeutic regimens on tumor necrosis factor ? (TNF) release...
  7. Clark T, Diakite M, Auburn S, Campino S, Fry A, Green A, et al. Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. J Infect Dis. 2009;199:569-75 pubmed publisher
    The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe ..
  8. Hosgood H, Au W, Kim H, Liu J, Hu W, Tse J, et al. IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations. Int J Hematol. 2013;97:793-9 pubmed publisher
    ..003), specifically DLBCL (per-allele OR = 0.69, 95 % CI 0.55-0.86; p trend = 0.001). Our findings suggest that genetic variation in IL10 and TNF may also play a role in lymphomagenesis in Asian populations. ..
  9. Belfer I, Wu T, Hipp H, Walter J, Scully M, Nyquist P, et al. Linkage of large-vessel carotid atherosclerotic stroke to inflammatory genes via a systematic screen. Int J Stroke. 2010;5:145-51 pubmed publisher
    ..These results suggest that genetic polymorphisms in proinflammatory genes may contribute to interindividual differences in the development of symptomatic carotid atherosclerotic disease. ..

More Information

Publications823 found, 100 shown here

  1. Queiroz D, Oliveira A, Saraiva I, Rocha G, Rocha A, das Graças Pimenta Sanna M, et al. Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2009;15:353-8 pubmed publisher
    ..Our aim was to investigate associations among IL1B-511, IL1B-31, IL1RN, TNFA-307, TLR-2, TLR-4, IL2-330, NOD2 G908R, NOD2 L1007fsinsC polymorphisms and both Crohn's disease (CD) and ulcerative ..
  2. Papadopoulou E, Tripsianis G, Anagnostopoulos K, Tentes I, Kakolyris S, Galazios G, et al. Significance of serum tumor necrosis factor-alpha and its combination with HER-2 codon 655 polymorphism in the diagnosis and prognosis of breast cancer. Int J Biol Markers. 2010;25:126-35 pubmed
    ..The present study was conducted to clarify the diagnostic and prognostic significance of TNF-alpha and its combination with HER-2 Ile655Val SNP in breast cancer...
  3. Fan H, Wang Z, Feng F, Zhang K, Yuan J, Sui H, et al. Association of TNF-alpha-238G/A and 308 G/A gene polymorphisms with pulmonary tuberculosis among patients with coal worker's pneumoconiosis. Biomed Environ Sci. 2010;23:137-45 pubmed publisher
    b>Tumor necrosis factor-alpha (TNF-alpha) may play an important role in host's immune response to mycobacterium tuberculosis (M. tuberculosis) infection...
  4. Lee Y, Harley J, Nath S. Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet. 2006;14:364-71 pubmed
    Alleles of tumor necrosis factor-alpha (TNF-alpha) gene have been inconsistently associated with systemic lupus erythematosus (SLE), particularly the 308-A/G functional promoter polymorphism...
  5. Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, et al. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). J Infect Dis. 2009;199:419-26 pubmed publisher
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection. ..
  6. Shen C, Sun H, Sun D, Xu L, Zhang X, Liu A, et al. Polymorphisms of tumor necrosis factor-alpha and breast cancer risk: a meta-analysis. Breast Cancer Res Treat. 2011;126:763-70 pubmed publisher
    We conducted a meta-analysis to assess the association between tumor necrosis factor-alpha (TNF-alpha) gene TNFA -308 (G>A), TNFA -238 (G>A), TNFA -857 (C>T), TNFA -863 (C>A), TNFA -1031 (T>C), TNFA -1210 (A>T) ..
  7. McDaniel D, Barber W, Nguyan C, Rhodes S, May W, McDaniel L, et al. Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients. Transpl Immunol. 2003;11:107-19 pubmed
    ..Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy. ..
  8. Hwang J, Jo K, Lee Y, Sung B, Park Y, Lee J. Upregulation of CD9 in ovarian cancer is related to the induction of TNF-? gene expression and constitutive NF-?B activation. Carcinogenesis. 2012;33:77-83 pubmed publisher
    ..Among the many upregulated genes, tumor necrosis factor (TNF)-? was induced in CD9/SKOV3 cells...
  9. Cvetkovic J, Wallberg Jonsson S, Stegmayr B, Rantapaa Dahlqvist S, Lefvert A. Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha, IL-1beta, and IL-1Ra genes. J Rheumatol. 2002;29:212-9 pubmed
    ..tandem repeat polymorphism of IL-I receptor antagonist (IL-1Ra) gene and NcoI RFLP at position -308 of tumor necrosis factor-alpha (TNF-alpha) gene...
  10. Zhang Q, Wang H, Bhutani G, Liu X, Paessler M, Tobias J, et al. Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosis. Proc Natl Acad Sci U S A. 2009;106:15843-8 pubmed publisher
    ..These findings provide additional rationale for the therapeutic inhibition of DNA methyltransferases in ALK+ TCL. They also suggest that treatment with TNFalpha may be highly effective in this type of lymphoma. ..
  11. Bouhaha R, Baroudi T, Ennafaa H, Vaillant E, Abid H, Sassi R, et al. Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population. Clin Biochem. 2010;43:549-52 pubmed publisher
    ..03, p(corrected)=0.0033) is likely to be a random result. SNPs IL6 -174G/C and TNFalpha -308G/A are not major contributors to T2D or obesity risk in our Tunisian population. ..
  12. Price N, Gilman R, Uddin J, Recavarren S, Friedland J. Unopposed matrix metalloproteinase-9 expression in human tuberculous granuloma and the role of TNF-alpha-dependent monocyte networks. J Immunol. 2003;171:5579-86 pubmed
    ..In summary, MMP-9 within tuberculous granuloma is associated with tissue destruction, and TNF-alpha, critical for antimycobacterial granuloma formation, is a key autocrine and paracrine regulator of MMP-9 secretion. ..
  13. Rodriguez Rodriguez L, Gonzalez Juanatey C, Palomino Morales R, Vazquez Rodriguez T, Miranda Filloy J, Fernandez Gutierrez B, et al. TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis. Atherosclerosis. 2011;216:125-30 pubmed publisher
    To assess the influence of the TNFA rs1800629 (G > A) polymorphism in the risk of cardiovascular (CV) disease and subclinical atherosclerosis in patients with rheumatoid arthritis (RA).
  14. Noguchi E, Yokouchi Y, Shibasaki M, Inudou M, Nakahara S, Nogami T, et al. Association between TNFA polymorphism and the development of asthma in the Japanese population. Am J Respir Crit Care Med. 2002;166:43-6 pubmed
    b>Tumor necrosis factor (TNF) is a proinflammatory cytokine that participates in the inflammatory reaction in patients with asthma...
  15. Jung K, Ha E, Yu G, Kim S, Chung W, Jang B, et al. TNFalpha promoter polymorphism is a risk factor for susceptibility in hepatocellular carcinoma in Korean population. Clin Chim Acta. 2009;407:16-9 pubmed publisher
    ..018). Our data imply that TNFalpha G-238A and C-857T, not C-863A, polymorphisms may confer different susceptibilities to the development of HCC with TNFalpha -238A and -857T alleles playing as risk factors. ..
  16. Tosun M, Celik H, Avci B, Yavuz E, Alper T, Malatyalioglu E. Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia. J Matern Fetal Neonatal Med. 2010;23:880-6 pubmed publisher investigate the relationship of maternal and umbilical cord interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) serum levels with the existence and severity of preeclampsia...
  17. Wang Q, Sun A, Song J, Chen Y, Wang J, Li C. Cytokine tumor necrosis factor alpha induces intestinal epithelial barrier dysfunction. Cytokine. 2012;58:226-30 pubmed publisher
    ..The expression of tumor necrosis factor alpha (TNFα) and its role in compromising the barrier function in the intestinal epithelial cells, T84 cells,..
  18. Kim T, Pyo C, Hur S, Kim Y, Hwang H, Youn J, et al. Polymorphisms of tumor necrosis factor (TNF) alpha and beta genes in Korean patients with psoriasis. Arch Dermatol Res. 2003;295:8-13 pubmed
    To evaluate the association of TNF-alpha (TNFA) and TNF-beta (TNFB) polymorphisms with psoriasis in the Korean population, we investigated TNF-alpha -238 and -308 promoter region and TNF-beta NcoI polymorphism using PCR-RFLP in 103 Korean ..
  19. Séguin C, Pilliar R, Roughley P, Kandel R. Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine (Phila Pa 1976). 2005;30:1940-8 pubmed
    ..induction of tissue degradation in in vitro formed nucleus pulposus (NP) tissues following incubation with tumor necrosis factor (TNF)alpha...
  20. Criswell L, Lum R, Turner K, Woehl B, Zhu Y, Wang J, et al. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis Rheum. 2004;50:2750-6 pubmed
    ..These findings may have clinical application through the identification of patients who are most likely to benefit from treatment with methotrexate or etanercept. ..
  21. Lech Maranda E, Mlynarski W, Grzybowska Izydorczyk O, Borowiec M, Pastorczak A, Cebula Obrzut B, et al. Polymorphisms of TNF and IL-10 genes and clinical outcome of patients with chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2013;52:287-96 pubmed publisher
    Genetic variations in tumor necrosis factor (TNF) and interleukin-10 (IL-10) were reported to influence susceptibility to and outcome of patients with non-Hodgkin lymphoma...
  22. Govan V, Constant D, Hoffman M, Williamson A. The allelic distribution of -308 Tumor Necrosis Factor-alpha gene polymorphism in South African women with cervical cancer and control women. BMC Cancer. 2006;6:24 pubmed
    ..The tumor necrosis factor alpha (TNF-alpha) cytokine plays an important role in all stages of cervical cancer and has the ability to ..
  23. Waterer G, Quasney M, Cantor R, Wunderink R. Septic shock and respiratory failure in community-acquired pneumonia have different TNF polymorphism associations. Am J Respir Crit Care Med. 2001;163:1599-604 pubmed
    ..19/0.07/0.09 (p = 0.01 AA versus non-AA); TNFalpha-308 0.16/0.06/0.12 (p = NS). Carrying at least one AA (tumor necrosis factor [TNF] high secretor) genotype had an 18.0% risk of SS versus 6.8% (p = 0.006)...
  24. Palucka A, Blanck J, Bennett L, Pascual V, Banchereau J. Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proc Natl Acad Sci U S A. 2005;102:3372-7 pubmed
    ..These results, therefore, might provide a mechanistic explanation for the development of anti-dsDNA antibodies and lupus-like syndrome in patients undergoing anti-TNF therapy. ..
  25. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 2005;120:649-61 pubmed
    ..Antioxidant treatment also prevents TNFalpha-mediated fulminant liver failure without affecting liver regeneration. ..
  26. DeMeo D, Campbell E, Barker A, Brantly M, Eden E, McElvaney N, et al. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol. 2008;38:114-20 pubmed
    ..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency. ..
  27. Nikitina Zake L, Cimdina I, Rumba I, Dabadghao P, Sanjeevi C. Major histocompatibility complex class I chain related (MIC) A gene, TNFa microsatellite alleles and TNFB alleles in juvenile idiopathic arthritis patients from Latvia. Hum Immunol. 2002;63:418-23 pubmed
    In order to analyze involvement of major histocompatibility complex class I chain-related gene A (MICA) and tumor necrosis factor a (TNFa) microsatellite polymorphisms as well as TNFB gene in juvenile idiopathic arthritis (JIA), we ..
  28. Yoo C, Hwang W, Hong S, Lee H, Jeong H, Kim S, et al. Relationship between iris constitution analysis and TNF-alpha gene polymorphism in hypertensives. Am J Chin Med. 2007;35:621-9 pubmed
    ..Iris constitution has a strong hereditary component. Tumor necrosis factor-alpha (TNFalpha), a pleiotropic cytokine, has been implicated in many pathological processes including ..
  29. Rahman P, Siannis F, Butt C, Farewell V, Peddle L, Pellett F, et al. TNFalpha polymorphisms and risk of psoriatic arthritis. Ann Rheum Dis. 2006;65:919-23 pubmed
    ..29 (95% confidence interval, 1.48 to 3.55)). Analysis of TNFalpha variants in psoriatic arthritis populations shows that the -238 (A) variant is a significant risk factor for this disease. ..
  30. Perez Luque E, Malacara J, Garay Sevilla M, Fajardo M. Association of the TNF-? -308G/A polymorphism with family history of type 2 diabetes mellitus in a Mexican population. Clin Biochem. 2012;45:12-5 pubmed publisher
    ..80; CI=1.77-18.98, p<0.0003). Our results suggest that TNF-? -308G/A polymorphism is associated with DM2 family history and is a risk factor for DM2. ..
  31. Lutz J, Huwiler K, Fedczyna T, Lechman T, Crawford S, Kinsella T, et al. Increased plasma thrombospondin-1 (TSP-1) levels are associated with the TNF alpha-308A allele in children with juvenile dermatomyositis. Clin Immunol. 2002;103:260-3 pubmed
    Vascular occlusion is more frequent in children with juvenile dermatomyositis (JDM) who have the TNF alpha-308A allele. One of the potent anti-angiogenic factors is thrombospondin-1 (TSP-1)...
  32. Jiang L, He B, Zhao M, Ning L, Li X, Yao W. Association of gene polymorphisms of tumour necrosis factor-alpha and interleukin-13 with chronic obstructive pulmonary disease in Han nationality in Beijing. Chin Med J (Engl). 2005;118:541-7 pubmed
    ..Thus, it does not appear that these SNPs are independent factors in COPD for Han nationality in Beijing. However, these SNPs may increase the risk of COPD among smokers. ..
  33. Ishii T, Hirose H, Saito I, Nishikai K, Maruyama H, Saruta T. Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men. Metabolism. 2000;49:1616-8 pubmed
    In obese subjects, the levels of tumor necrosis factor alpha (TNF-alpha) expression and protein synthesis in adipocytes are increased...
  34. Dmitrienko S, Hoar D, Balshaw R, Keown P. Immune response gene polymorphisms in renal transplant recipients. Transplantation. 2005;80:1773-82 pubmed
    ..Subsidiary analyses suggesting an influence of CD40L and TGFbeta1 genes on graft survival require independent confirmation. ..
  35. Cackovic M, Buhimschi C, Zhao G, Funai E, Norwitz E, Kuczynski E, et al. Fractional excretion of tumor necrosis factor-alpha in women with severe preeclampsia. Obstet Gynecol. 2008;112:93-100 pubmed publisher
    ..We sought to estimate the fractional excretion of tumor necrosis factor (TNF)-alpha in relationship to proteinuria in women with severe preeclampsia...
  36. McGuire W, Hill A, Allsopp C, Greenwood B, Kwiatkowski D. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature. 1994;371:508-10 pubmed
    ..The maintenance of the TNF2 allele at a gene frequency of 0.16 in The Gambia implies that the increased risk of cerebral malaria in homozygotes is counterbalanced by some biological advantage. ..
  37. Matsumiya T, Ota K, Imaizumi T, Yoshida H, Kimura H, Satoh K. Characterization of synergistic induction of CX3CL1/fractalkine by TNF-alpha and IFN-gamma in vascular endothelial cells: an essential role for TNF-alpha in post-transcriptional regulation of CX3CL1. J Immunol. 2010;184:4205-14 pubmed publisher
    ..CX3CL1 expression is under control of posttranscriptional regulation, which is involved in the synergistic induction of CX3CL1 in response to the combined stimulation with TNF-alpha and IFN-gamma. ..
  38. Daher S, Shulzhenko N, Morgun A, Mattar R, Rampim G, Camano L, et al. Associations between cytokine gene polymorphisms and recurrent pregnancy loss. J Reprod Immunol. 2003;58:69-77 pubmed
    ..18). We believe that the associations of these genotypes with RPL are interesting not only as risk factors but also because they represent another piece of evidence that these cytokines might be important in the pathogenesis of RPL. ..
  39. García Gonzalez M, Lanas A, Quintero E, Nicolas D, Parra Blanco A, Strunk M, et al. Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. Am J Gastroenterol. 2007;102:1878-92 pubmed
    ..GC and 404 sex- and age-matched healthy controls was typed for several functional polymorphisms in pro- (IL-1B, TNFA, LTA, IL-12p40) and anti-inflammatory (IL-4, IL-1RN, IL-10, TGFB1) genes by PCR, RFLP, and TaqMan assays. H...
  40. Hohler T, Grossmann S, Stradmann Bellinghausen B, Kaluza W, Reuss E, de Vlam K, et al. Differential association of polymorphisms in the TNFalpha region with psoriatic arthritis but not psoriasis. Ann Rheum Dis. 2002;61:213-8 pubmed
    ..white controls was investigated for two TNFalpha promoter (-238 and -308) and three microsatellite polymorphisms (TNFa, c, and d)...
  41. Ye D, Ma I, Ma T. Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol. 2006;290:G496-504 pubmed
    ..NF-kappaB p50/p65 activation of the MLCK promoter then leads to a stepwise increase in MLCK transcription, expression and activity, and MLCK-mediated opening of the intestinal TJ barrier. ..
  42. Nishibu A, Oyama N, Nakamura K, Kaneko F. Lack of association of TNF-238A and -308A in Japanese patients with psoriasis vulgaris, psoriatic arthritis and generalized pustular psoriasis. J Dermatol Sci. 2002;29:181-4 pubmed
    b>Tumor necrosis factor (TNF)-alpha is one of the proinflammatory cytokines and immunomodulators, and has an important pathogenetic role in psoriasis...
  43. Deghaide N, Rodrigues M, Castelli E, Mendes Junior C, Figueiredo J, Donadi E. Tumor necrosis factor region polymorphisms are associated with AIDS and with cytomegalovirus retinitis. AIDS. 2009;23:1641-7 pubmed publisher
    The tumor necrosis factor (TNF) gene is located within the highly polymorphic major histocompatibility complex region, exhibiting the -308 GA promoter region polymorphism and six microsatellites (TNFa-f) spanning the region nearby the ..
  44. Liang W, Lv M, Su X, Gao L, Fang W, Luo H, et al. Association of tumor necrosis factor gene polymorphisms with susceptibility to dilated cardiomyopathy in a Han Chinese population. DNA Cell Biol. 2010;29:625-8 pubmed publisher
    b>Tumor necrosis factor (TNF) is an immunomodulatory cytokine that plays an important role in many inflammatory and autoimmune diseases. We investigated the correlation between single-nucleotide polymorphisms of the TNF gene [i.e...
  45. Ghaderi M, Nikitina Zake L, Wallin K, Wiklund F, Hallmans G, Lenner P, et al. Tumor necrosis factor A and MHC class I chain related gene A (MIC-A) polymorphisms in Swedish patients with cervical cancer. Hum Immunol. 2001;62:1153-8 pubmed
    ..Microsatellite polymorphism of the TNFA gene located in the class III region and a short tandem repeat polymorphism of the MICA gene located in the ..
  46. Silva M, Simões R, Castelli E, Mendes Junior C, Deghaide N, Tsuda L, et al. TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients. Int J Immunogenet. 2010;37:379-85 pubmed publisher
    The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS)...
  47. Ramasawmy R, Fae K, Spina G, Victora G, Tanaka A, Palácios S, et al. Association of polymorphisms within the promoter region of the tumor necrosis factor-alpha with clinical outcomes of rheumatic fever. Mol Immunol. 2007;44:1873-8 pubmed
    ..The TNFA gene has been associated with a number of autoimmune diseases, including RF...
  48. Chiang C, Chuang C, Liu S, Shen H. Genetic polymorphism of transforming growth factor ?1 and tumor necrosis factor ? is associated with asthma and modulates the severity of asthma. Respir Care. 2013;58:1343-50 pubmed publisher
    The role of transforming growth factor ?1 (TGF-?1) and tumor necrosis factor ? (TNF-?) in asthma is unclear...
  49. Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell. 2012;148:228-43 pubmed publisher
    ..Drp1 activation caused mitochondrial fragmentation, an early and obligatory step for necrosis execution. These data defined PGAM5 as the convergent point for multiple necrosis pathways. ..
  50. Asghar T, Yoshida S, Kennedy S, Negoro K, Zhuo W, Hamana S, et al. The tumor necrosis factor-alpha promoter -1031C polymorphism is associated with decreased risk of endometriosis in a Japanese population. Hum Reprod. 2004;19:2509-14 pubmed
    b>Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional proinflammatory cytokine, associated with various inflammatory and autoimmune diseases...
  51. Magalhães R, Biral A, Pancoto J, Donadi E, Mendes C, Magna L, et al. Human leukocyte antigen (HLA) and single nucleotide polymorphisms (SNPs) tumor necrosis factor (TNF)-alpha -238 and -308 as genetic markers of susceptibility to psoriasis and severity of the disease in a long-term follow-up Brazilian study. Int J Dermatol. 2010;49:1133-40 pubmed
    The strongest genetic marker for psoriasis is Cw*06. Polymorphisms in the tumor necrosis factor (TNF)-alpha promoter region, especially replacement of guanine with adenine in positions -238 and -308 are related to higher TNF-alpha ..
  52. Kamangar F, Abnet C, Hutchinson A, Newschaffer C, Helzlsouer K, Shugart Y, et al. Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control. 2006;17:117-25 pubmed
    ..G/C), IL-8RB (Exon 3 +1235 T/C, Exon 3 +811 C/T, and Exon 3 +1010 G/A), IL-10 (-819 C/T, -592 C/A, -1082 A/G), and TNF A (-308 G/A, -238 G/A)...
  53. Gaudet M, Milne R, Cox A, Camp N, Goode E, Humphreys M, et al. Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2009;18:1610-6 pubmed publisher
  54. Sookoian S, Garcia S, Gianotti T, Dieuzeide G, Gonzalez C, Pirola C. The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome. Am J Hypertens. 2005;18:1271-5 pubmed
    b>Tumor necrosis factor-alpha (TNF-alpha) has been associated with obesity, obesity-related hypertension, and metabolic syndrome...
  55. Kuesap J, Hirayama K, Kikuchi M, Ruangweerayut R, Na Bangchang K. Study on association between genetic polymorphisms of haem oxygenase-1, tumour necrosis factor, cadmium exposure and malaria pathogenicity and severity. Malar J. 2010;9:260 pubmed publisher
    ..Further study in larger sample size is required. ..
  56. Viemann D, Goebeler M, Schmid S, Klimmek K, Sorg C, Ludwig S, et al. Transcriptional profiling of IKK2/NF-kappa B- and p38 MAP kinase-dependent gene expression in TNF-alpha-stimulated primary human endothelial cells. Blood. 2004;103:3365-73 pubmed
    Inflammatory stimulation of endothelial cells by tumor necrosis factor alpha (TNF-alpha) involves activation of nuclear factor kappa B (NF-kappa B) and p38 mitogen-activated protein (MAP) kinase signaling pathways...
  57. Morange P, Tregouet D, Godefroy T, Saut N, Bickel C, Rupprecht H, et al. Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study. J Mol Med (Berl). 2008;86:1153-61 pubmed publisher
    b>Tumor necrosis factor (TNF) is a major cytokine involved in inflammatory reaction and a mortality predictor in patients with coronary artery disease (CAD)...
  58. Landi S, Moreno V, Gioia Patricola L, Guino E, Navarro M, De Oca J, et al. Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. Cancer Res. 2003;63:3560-6 pubmed
    ..between single nucleotide polymorphisms in the interleukin (IL)-6 (-174 G>C), IL8 (-251T>A), tumor necrosis factor alpha (-308G>A), and PPARG (Pro12Ala) genes and the risk of CRC in a group of 377 cases and 326 controls ..
  59. Bhushan B, Guleria R, Misra A, Luthra K, Vikram N. TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea. Respir Med. 2009;103:386-92 pubmed publisher
    Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA...
  60. Askling J, Fahrbach K, Nordstrom B, Ross S, Schmid C, Symmons D. Cancer risk with tumor necrosis factor alpha (TNF) inhibitors: meta-analysis of randomized controlled trials of adalimumab, etanercept, and infliximab using patient level data. Pharmacoepidemiol Drug Saf. 2011;20:119-30 pubmed publisher
    ..Long-term risk assessment requires observational studies. ..
  61. Schmidt R, Bültmann A, Fischel S, Gillitzer A, Cullen P, Walch A, et al. Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes. Circ Res. 2008;102:302-9 pubmed
    ..activation (according to Western blot) in monocytes with increased MMP-9 (zymography), interleukin-6, and tumor necrosis factor-alpha secretion (according to ELISA) by monocytes...
  62. Hassan A, Fathi M, Dastmalchi M, Lundberg I, Padyukov L. Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis. J Autoimmun. 2006;27:62-8 pubmed
    ..These levels were correlated to the G-308A TNFA, G-1087A IL10 and G915C TGFB1 gene polymorphisms and haplotype frequencies, gender, autoantibody profiles and ..
  63. Jang Y, Koh S, Kim O, Kim B, Choi D, Hyun Y, et al. Effect of the 252A>G polymorphism of the lymphotoxin-alpha gene on inflammatory markers of response to cigarette smoking in Korean healthy men. Clin Chim Acta. 2007;377:221-7 pubmed
    ..The detrimental effect of smoking is most clearly seen in men with G/G, suggesting a genotype-specific interaction with smoking. ..
  64. Willer C, Bonnycastle L, Conneely K, Duren W, Jackson A, Scott L, et al. Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes. 2007;56:256-64 pubmed
    ..03), although we also replicated 4 of 58 SNPs from genes that had only one previous report of association. ..
  65. Ribeiro C, Visentainer J, Moliterno R. Association of cytokine genetic polymorphism with hepatitis B infection evolution in adult patients. Mem Inst Oswaldo Cruz. 2007;102:435-40 pubmed
    ..67; IC95% = 0.42-141.63). Further studies in other populations, and evaluation of a greater number of individuals could contribute for a better understanding of the cytokine genetic polymorphism influence in HBV infection evolution. ..
  66. Soga Y, Nishimura F, Ohyama H, Maeda H, Takashiba S, Murayama Y. Tumor necrosis factor-alpha gene (TNF-alpha) -1031/-863, -857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese. J Clin Periodontol. 2003;30:524-31 pubmed
  67. Gingo M, Silveira L, Miller Y, Friedlander A, Cosgrove G, Chan E, et al. Tumour necrosis factor gene polymorphisms are associated with COPD. Eur Respir J. 2008;31:1005-12 pubmed publisher
    ..22, 95% CI 0.05-0.97). The present study adds further evidence that tumour necrosis factor genotypes play a role in susceptibility to cigarette smoke. ..
  68. Melo Barbosa H, Martins L, dos Santos S, Demachki S, Assumpção M, Aragão C, et al. Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population. World J Gastroenterol. 2009;15:1465-71 pubmed
    To study the association between Interleukin-1 (IL-1) and tumor necrosis factor (TNF)-alpha polymorphisms, infection by Helicobacter pylori (H pylori) and the development of gastrointestinal diseases...
  69. Fonseca J, Cavaleiro J, Teles J, Sousa E, Andreozzi V, Antunes M, et al. Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter. Arthritis Res Ther. 2007;9:R37 pubmed
    ..was to assess whether clinical measures of rheumatoid arthritis activity and severity were influenced by tumor necrosis factor-alpha (TNF-alpha) promoter genotype/haplotype markers...
  70. Zhuang L, Ma W, Cai D, Zhong H, Sun Q. Associations between tumor necrosis factor-? polymorphisms and risk of psoriasis: a meta-analysis. PLoS ONE. 2013;8:e68827 pubmed publisher
    b>Tumor necrosis factor-? (TNF-?) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-? polymorphisms and psoriasis risk...
  71. Tambur A, Ortegel J, Ben Ari Z, Shabtai E, Klein T, Michowiz R, et al. Role of cytokine gene polymorphism in hepatitis C recurrence and allograft rejection among liver transplant recipients. Transplantation. 2001;71:1475-80 pubmed
  72. Welsh P, Lowe G, Chalmers J, Campbell D, Rumley A, Neal B, et al. Associations of proinflammatory cytokines with the risk of recurrent stroke. Stroke. 2008;39:2226-30 pubmed publisher
    ..We studied the association of interleukin (IL)-6, IL-18, and tumor necrosis factor-alpha (TNF-alpha) with recurrent stroke in a nested case-control study derived from the Perindopril ..
  73. Jiffri E, Elhawary N. The impact of common tumor necrosis factor haplotypes on the development of asthma in children: an Egyptian model. Genet Test Mol Biomarkers. 2011;15:293-9 pubmed publisher
    Conflicting results have arisen among different ethnic populations with regard to the ability of tumor necrosis factor (TNF) to control the development of bronchial asthma...
  74. Xia Q, Zhou L, Liu D, Chen Z, Chen F. Relationship between TNF-<alpha> gene promoter polymorphisms and outcomes of hepatitis B virus infections: a meta-analysis. PLoS ONE. 2011;6:e19606 pubmed publisher
    ..B virus (HBV) is a complex process which may be influenced by many factors including polymorphisms in the tumor necrosis factor <alpha> (TNF-<alpha>) gene promoter...
  75. Guzmán Flores J, Muñoz Valle J, Sanchez Corona J, Cobián J, Medina Carrillo L, García Zapién A, et al. Tumor necrosis factor-alpha gene promoter -308G/A and -238G/A polymorphisms in Mexican patients with type 2 diabetes mellitus. Dis Markers. 2011;30:19-24 pubmed publisher
    The association between some Tumor necrosis factor-alpha (TNF-?) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results...
  76. Berković M, Cacev T, Zjacic Rotkvic V, Kapitanovic S. TNF-alpha promoter single nucleotide polymorphisms in gastroenteropancreatic neuroendocrine tumors. Neuroendocrinology. 2006;84:346-52 pubmed
    ..neuroendocrine tumors (GEP-NETs) secrete biogenic amines, hormones and growth factors, tumor necrosis factor-alpha (TNF-alpha) being one of them...
  77. Yang Y, Luo C, Feng R, Bi S. The TNF-?, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis. J Cancer Res Clin Oncol. 2011;137:947-52 pubmed publisher
    ..TNF-?-308 G/A polymorphism is assumed to confer a higher risk for HCC, especially in Asian population. TNF-?-238 G/A, IL-1B-31 T/C, -511 C/T, and IL-10-1082 G/A polymorphisms were not detected to be related to the risk for HCC. ..
  78. Teuffel O, Ethier M, Beyene J, Sung L. Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis. Crit Care Med. 2010;38:276-82 pubmed publisher
    The tumor necrosis factor (TNF)-alpha promoter -308 A/G polymorphism has been reported to be associated with sepsis with inconsistent results...
  79. Baseggio L, Bartholin L, Chantome A, Charlot C, Rimokh R, Salles G. Allele-specific binding to the -308 single nucleotide polymorphism site in the tumour necrosis factor-alpha promoter. Eur J Immunogenet. 2004;31:15-9 pubmed
    ..Here we confirm that a specific DNA complex binds preferentially the variant TNF2 allele in various cell types and demonstrate that activating protein (AP)-2, myeloid zinc finger gene 1 (MZF-1) and Sp1 are not involved in this complex. ..
  80. Szabó K, Tax G, Teodorescu Brinzeu D, Koreck A, Kemeny L. TNF? gene polymorphisms in the pathogenesis of acne vulgaris. Arch Dermatol Res. 2011;303:19-27 pubmed publisher
    ..b>Tumor necrosis factor alpha (TNF?) is a central molecule coded by a gene that shows high level of genetic polymorphisms especially ..
  81. Johnston D, Dong B, Hughes C. TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. Gene. 2009;435:36-44 pubmed publisher
    ..Full promoter activity also depends on an AP-1 site at -2.0 kb. These results indicate that canonical NFkappaB signaling is required for TNF induction of the notch ligand jagged-1 in EC. ..
  82. Fortunato S, Menon R, Velez D, Thorsen P, Williams S. Racial disparity in maternal-fetal genetic epistasis in spontaneous preterm birth. Am J Obstet Gynecol. 2008;198:666.e1-9; discussion 666.e9-10 pubmed publisher
    To understand the differences in genetic interactions among tumor necrosis factor-alpha, interleukin-6 and their receptor gene variants between black and white patients in spontaneous preterm birth...
  83. Pooja S, Francis A, Bid H, Kumar S, Rajender S, Ramalingam K, et al. Role of ethnic variations in TNF-? and TNF-? polymorphisms and risk of breast cancer in India. Breast Cancer Res Treat. 2011;126:739-47 pubmed publisher
    ..In conclusion, TNF-? and -? polymorphisms are strongly associated with breast cancer in the Dravidian but not in the Indo-European group. ..
  84. Dilek K, Ozçimen A, Saricaoglu H, Saba D, Yucel A, Yurtkuran M, et al. Cytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings. Clin Exp Rheumatol. 2009;27:S73-8 pubmed
    ..Also, to confirm the biological significance of our results, further studies should be performed on other population groups and in large number of cases. ..
  85. Wang D, Yang Y, Xia Q, Lan Y, Wang M, Zhang X, et al. [On the association of tumor necrosis factor-alpha gene polymorphisms with the susceptibility to silicosis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005;36:679-82, 712 pubmed
    To find out whether -308 and -238 locus (G --> A) mutation within the tumor necrosis factor-alpha gene (TNF-alpha) promoter region are associated with susceptibility to silicosis in the Han population of southwest China...
  86. Kieszko R, Krawczyk P, Chocholska S, Dmoszynska A, Milanowski J. TNF-alpha and TNF-beta gene polymorphisms in Polish patients with sarcoidosis. Connection with the susceptibility and prognosis. Sarcoidosis Vasc Diffuse Lung Dis. 2010;27:131-7 pubmed
    ..The analysis of -308G > A TNF-alpha gene (TNFA*1 and TNFA*2 alleles) and 252A > G TNF-beta gene polymorphisms (TNFB*1 and TNFB*2 alleles) were performed...
  87. Wang N, Yin D, Zhang S, Wei H, Wang S, Zhang Y, et al. TNF-alpha rs1800629 polymorphism is not associated with HPV infection or cervical cancer in the Chinese population. PLoS ONE. 2012;7:e45246 pubmed publisher
    ..b>Tumor necrosis factor alpha (TNF-alpha), involved in the defense against HPV infection, plays an important role in cervical cancer ..
  88. Seifart C, Plagens A, Dempfle A, Clostermann U, Vogelmeier C, von Wichert P, et al. TNF-alpha, TNF-beta, IL-6, and IL-10 polymorphisms in patients with lung cancer. Dis Markers. 2005;21:157-65 pubmed
    ..The functional IL-10-1082 polymorphism correlates with altered IL-10 levels and might influence lung cancer susceptibility by altered inflammatory responses in the airways. ..
  89. Zhu X, Wang Y, Sun L, Song Y, Sun F, Tang L, et al. A novel gene variation of TNFalpha associated with ankylosing spondylitis: a reconfirmed study. Ann Rheum Dis. 2007;66:1419-22 pubmed
    ..The TNFalpha locus was reconfirmed and showed association with susceptibility to AS. It may be independent of HLA-B27. A range of 58 kb covering TNFalpha had strong LD to AS. ..
  90. Varfolomeev E, Goncharov T, Fedorova A, Dynek J, Zobel K, Deshayes K, et al. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J Biol Chem. 2008;283:24295-9 pubmed publisher
    ..c-IAP1 and c-IAP2 are recruited to tumor necrosis factor receptor 1 (TNFR1)-associated complexes where they can regulate receptor-mediated signaling...
  91. Aguillón J, Cruzat A, Aravena O, Salazar L, Llanos C, Cuchacovich M. Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?. Immunobiology. 2006;211:75-84 pubmed
    ..We suggest that RA, a relatively new and increasingly frequent disease, is favored by the presence of the -308 TNF promoter polymorphism, responsible for increased TNF production. ..
  92. Oliveira L, Porta G, Marin M, Bittencourt P, Kalil J, Goldberg A. Autoimmune hepatitis, HLA and extended haplotypes. Autoimmun Rev. 2011;10:189-93 pubmed publisher
    ..We genotyped 107 AIH-1 children and up to 326 healthy subjects for TNFA G-308A, TNFA G-238A, LTA A+252G, LTA A+80C, NFKBIL1 T-63A, BAT1 C-348T, BAT1 G-22C, MICA, and HLA-B polymorphisms...