Gene Symbol: TNF-alpha
Description: tumor necrosis factor
Alias: DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F, tumor necrosis factor, APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor ligand 1F, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Species: human
Products:     TNF-alpha

Top Publications

  1. Liu X, Kelm R, Strauch A. Transforming growth factor beta1-mediated activation of the smooth muscle alpha-actin gene in human pulmonary myofibroblasts is inhibited by tumor necrosis factor-alpha via mitogen-activated protein kinase kinase 1-dependent induction of the Egr-1 tr. Mol Biol Cell. 2009;20:2174-85 pubmed publisher
    ..We examined the ability of proinflammatory tumor necrosis factor (TNF)-alpha to antagonize TGFbeta1-mediated human pulmonary myofibroblast differentiation...
  2. Song Z, Song Y, Yin J, Shen Y, Yao C, Sun Z, et al. Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality. PLoS ONE. 2012;7:e46113 pubmed publisher
    b>Tumor necrosis factor (TNF) and TNF receptor superfamily (TNFR)-mediated immune response play an essential role in the pathogenesis of severe sepsis...
  3. Wang Y, Lan J, Yang L, Wang De J, Kuang J. TNF-? and IL-1RA polymorphisms and silicosis susceptibility in Chinese workers exposed to silica particles: a case-control study. Biomed Environ Sci. 2012;25:517-25 pubmed publisher
    ..Further independent studies on the interaction between SNPs and exposure to silica particles with a larger sample size are therefore warranted. ..
  4. Gregory A, Dendrou C, Attfield K, Haghikia A, Xifara D, Butter F, et al. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature. 2012;488:508-511 pubmed publisher
    ..Hence, our study demonstrates that clinical practice can be informed by comparing GWAS across common autoimmune diseases and by investigating the functional consequences of the disease-associated genetic variation. ..
  5. Clark T, Diakite M, Auburn S, Campino S, Fry A, Green A, et al. Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. J Infect Dis. 2009;199:569-75 pubmed publisher
    The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe ..
  6. Hosgood H, Au W, Kim H, Liu J, Hu W, Tse J, et al. IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations. Int J Hematol. 2013;97:793-9 pubmed publisher
    ..003), specifically DLBCL (per-allele OR = 0.69, 95 % CI 0.55-0.86; p trend = 0.001). Our findings suggest that genetic variation in IL10 and TNF may also play a role in lymphomagenesis in Asian populations. ..
  7. Belfer I, Wu T, Hipp H, Walter J, Scully M, Nyquist P, et al. Linkage of large-vessel carotid atherosclerotic stroke to inflammatory genes via a systematic screen. Int J Stroke. 2010;5:145-51 pubmed publisher
    ..These results suggest that genetic polymorphisms in proinflammatory genes may contribute to interindividual differences in the development of symptomatic carotid atherosclerotic disease. ..
  8. Papadopoulou E, Tripsianis G, Anagnostopoulos K, Tentes I, Kakolyris S, Galazios G, et al. Significance of serum tumor necrosis factor-alpha and its combination with HER-2 codon 655 polymorphism in the diagnosis and prognosis of breast cancer. Int J Biol Markers. 2010;25:126-35 pubmed
    ..The present study was conducted to clarify the diagnostic and prognostic significance of TNF-alpha and its combination with HER-2 Ile655Val SNP in breast cancer...
  9. Fan H, Wang Z, Feng F, Zhang K, Yuan J, Sui H, et al. Association of TNF-alpha-238G/A and 308 G/A gene polymorphisms with pulmonary tuberculosis among patients with coal worker's pneumoconiosis. Biomed Environ Sci. 2010;23:137-45 pubmed publisher
    b>Tumor necrosis factor-alpha (TNF-alpha) may play an important role in host's immune response to mycobacterium tuberculosis (M. tuberculosis) infection...

More Information

Publications686 found, 100 shown here

  1. Diaz Arrastia R, Gong Y, Kelly C, Gelman B. Host genetic polymorphisms in human immunodeficiency virus-related neurologic disease. J Neurovirol. 2004;10 Suppl 1:67-73 pubmed
    ..Future studies will require much larger sample sizes and technical advances to allow screening at larger number of candidate loci. ..
  2. Sun L, Wang H, Wang Z, He S, Chen S, Liao D, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148:213-27 pubmed publisher
    ..These findings implicate MLKL as a key mediator of necrosis signaling downstream of the kinase RIP3. ..
  3. Spink C, Keen L, Mensah F, Law G, Bidwell J, Morgan G. Association between non-Hodgkin lymphoma and haplotypes in the TNF region. Br J Haematol. 2006;133:293-300 pubmed
    ..Prediction of disease risk was improved by the addition of loci to the haplotype, demonstrating the importance of considering the haplotype-specific context of the loci in genetic risk assessment. ..
  4. Knight J, Udalova I, Hill A, Greenwood B, Peshu N, Marsh K, et al. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Nat Genet. 1999;22:145-50 pubmed
  5. Karplus T, Jeronimo S, Chang H, Helms B, Burns T, Murray J, et al. Association between the tumor necrosis factor locus and the clinical outcome of Leishmania chagasi infection. Infect Immun. 2002;70:6919-25 pubmed
    ..Due to the association of the tumor necrosis factor (TNF) locus with other infectious diseases, we examined whether polymorphic alleles at this locus are ..
  6. Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003;114:181-90 pubmed
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated. ..
  7. Gonzalez S, Rodrigo L, Martinez Borra J, Lopez Vazquez A, Fuentes D, Niño P, et al. TNF-alpha -308A promoter polymorphism is associated with enhanced TNF-alpha production and inflammatory activity in Crohn's patients with fistulizing disease. Am J Gastroenterol. 2003;98:1101-6 pubmed
    b>Tumor necrosis factor-alpha (TNF-alpha) plays a key role in the inflammatory response and pathogenesis of Crohn's disease (CD)...
  8. Gu L, Zhu W, Pan C, Zhao L, Zhang M, Liu J, et al. Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves' disease. Clin Biochem. 2010;43:223-7 pubmed publisher
    b>Tumor necrosis factor alpha (TNF-alpha) may play a central role in the development of Graves' disease (GD). The aim of this study was to investigate the association of TNF-alpha polymorphisms with GD in Chinese population...
  9. Oral H, Budak F, Uzaslan E, Basturk B, Bekar A, Akalin H, et al. Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis. Cytokine. 2006;35:143-7 pubmed
    ..To confirm the biological significance of our results, further studies should be performed on other population groups. ..
  10. Yucesoy B, Vallyathan V, Landsittel D, Sharp D, Weston A, Burleson G, et al. Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis. Toxicol Appl Pharmacol. 2001;172:75-82 pubmed
    ..These studies suggest that gene-environment interactions involving cytokine polymorphisms play a significant role in silicosis by modifying the extent of and susceptibility to disease. ..
  11. McHugh N, Owen P, Cox B, Dunphy J, Welsh K. MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus. Ann Rheum Dis. 2006;65:488-94 pubmed
    ..02; OR = 0.2 (0.05 to 0.8)). The strongest association in this predominantly white population with SLE was between HLA-DR3 and anti-La, which seemed to account for any associations with TNFalpha alleles on an extended DR3 haplotype. ..
  12. Rivas M, Tkach M, Beguelin W, Proietti C, Rosemblit C, Charreau E, et al. Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation. Breast Cancer Res Treat. 2010;122:111-24 pubmed publisher
    b>Tumor necrosis factor alpha (TNFalpha) is a pleiotropic cytokine which, acting locally, induces tumor growth. Accumulating evidence, including our findings, showed that TNFalpha is mitogenic in breast cancer cells in vitro and in vivo...
  13. Chen D, Zeng Y, Zhou J, Yang L, Jiang S, Huang J, et al. Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population. J Med Virol. 2010;82:371-8 pubmed publisher
    ..001). An interaction between CCR5 -2459, TNFA -863, IL-10RB codon 47, and MCP-1 -2518 was detected by MDR (P = 0.001)...
  14. Razeghinejad M, Rahat F, Kamali Sarvestani E. Association of TNFA -308 G/A and TNFRI +36 A/G gene polymorphisms with glaucoma. Ophthalmic Res. 2009;42:118-24 pubmed publisher
    ..Therefore, the association of single nucleotide polymorphisms in the TNFRI gene and the promoter region of the TNFA gene with glaucoma susceptibility was investigated in the present study...
  15. Lee S, Kim B, Yook J, Oh S, Lee I, Song K. TNF/LTA polymorphisms and risk for gastric cancer/duodenal ulcer in the Korean population. Cytokine. 2004;28:75-82 pubmed
    The tumor necrosis factor-alpha (TNF) and lymphotoxin-alpha (LTA) are proinflammatory cytokines with immunoregulatory effects. TNF is also known to inhibit gastric acid secretion...
  16. Martinelli E, Cicala C, Van Ryk D, Goode D, Macleod K, Arthos J, et al. HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2007;104:3396-401 pubmed
  17. Dunstan S, Stephens H, Blackwell J, Duc C, Lanh M, Dudbridge F, et al. Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam. J Infect Dis. 2001;183:261-268 pubmed
    ..locations in southern Vietnam were genotyped for HLA-DRB1 and HLA-DQB1 alleles, the gene that encodes tumor necrosis factor (TNF)-alpha (TNFA [-238] and TNFA [-308]), the gene that encodes lymphotoxin-alpha, and alleles of the TNF-..
  18. Mfuna Endam L, Cormier C, Bosse Y, Filali Mouhim A, Desrosiers M. Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study. Arch Otolaryngol Head Neck Surg. 2010;136:187-92 pubmed publisher
    ..This further supports the potential contribution of IL1A to the development of CRS. We were unable to replicate previous reports of associations with IL1B or TNF. ..
  19. Babel N, Vergopoulos A, Trappe R, Oertel S, Hammer M, Karaivanov S, et al. Evidence for genetic susceptibility towards development of posttransplant lymphoproliferative disorder in solid organ recipients. Transplantation. 2007;84:387-91 pubmed
    ..In the present case-control study, we analyzed the impact of -1082 interleukin (IL)-10, -308 tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 (codon 10, 25), and +874 interferon (IFN)-gamma gene ..
  20. Kummee P, Tangkijvanich P, Poovorawan Y, Hirankarn N. Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population. J Viral Hepat. 2007;14:841-8 pubmed
    ..Additional study is needed to validate these finding and to further explore the genetic pathogenesis of HBV infection. ..
  21. Whiteman D, Parmar P, Fahey P, Moore S, Stark M, Zhao Z, et al. Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers. Gastroenterology. 2010;139:73-83; quiz e11-2 pubmed publisher
    ..of H pylori seropositivity and single nucleotide polymorphisms in interleukin (IL)-1B (-31, -511) and tumor necrosis factor (TNF)-alpha (-308, -238) among 260 EAC, 298 EGJAC, and 208 ESCC patients and 1346 controls...
  22. Chen Y, Liu S, Chin C, Wu C, Chen C, Chang H, et al. Association of tumor necrosis factor-alpha-863C/A gene polymorphism with chronic obstructive pulmonary disease. Lung. 2010;188:339-47 pubmed publisher
    ..84, 95% CI = 0.74-0.96, p = 0.008) was the only independent predictor for mortality. The TNF-alpha -863 A allele may confer a degree of resistance to the susceptibility to and muscle wasting of COPD among heavy smokers. ..
  23. Sortica V, Cunha M, Ohnishi M, Souza J, Ribeiro Dos Santos A, Santos N, et al. IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with Plasmodium vivax malaria in Brazil. Malar J. 2012;11:409 pubmed publisher
    ..02, p?=?0.01 and p?=?0.01, respectively). Plasmodium vivax malaria pathophysiology is still poorly understood. The present findings reinforce and increase our understanding about the role of the immune system in malaria susceptibility. ..
  24. Barrett S, Collins M, Kenny C, Ryan E, Keane C, Crowe J. Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection. J Med Virol. 2003;71:212-8 pubmed
    ..Inheritance of some genotypes associated with polymorphisms of cytokine genes, such as IL-6, may be host genetic factors associated with outcome of HCV in a well-defined ethnically homogeneous cohort. ..
  25. Liu J, Xu A, Li Y, Du X, Tang X, Ou Y. Tumor necrosis factor-alpha-308G/A promoter polymorphism is associated with the susceptibility of polymyositis/dermatomyositis in a Chinese Han population. J Dermatol. 2007;34:353-5 pubmed
  26. van der Linden M, van der Slik A, Zanelli E, Giphart M, Pieterman E, Schreuder G, et al. Six microsatellite markers on the short arm of chromosome 6 in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus. Genes Immun. 2001;2:373-80 pubmed
    Differences in allelic distribution at loci surrounding the human HLA-DRB1 and tumor necrosis factor (TNF) genes have been observed in association with systemic lupus erythematosus (SLE)...
  27. Widegren H, Erjefalt J, Korsgren M, Andersson M, Greiff L. Effects of intranasal TNFalpha on granulocyte recruitment and activity in healthy subjects and patients with allergic rhinitis. Respir Res. 2008;9:15 pubmed publisher
    ..0021), but not the numbers of eosinophils. TNFalpha produces a nasal inflammatory response in humans that is characterised by late phase (i.e., 24 hours post challenge) neutrophil activity and plasma exudation. ..
  28. Tolgyesi G, Keszei M, Ungvári I, Nagy A, Falus A, Szalai C. Involvement of TNFalpha -308A promoter polymorphism in the development of asthma in children infected with Chlamydophila pneumoniae. Pediatr Res. 2006;60:543-8 pubmed
    ..C. pneumoniae-specific antibodies were measured by ELISA. Tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and RANTES (regulated on activation normal T ..
  29. Ahmad T, Wallace G, James T, Neville M, Bunce M, Mulcahy Hawes K, et al. Mapping the HLA association in Behçet's disease: a role for tumor necrosis factor polymorphisms?. Arthritis Rheum. 2003;48:807-13 pubmed
    Experimental evidence suggests that inappropriate regulation of tumor necrosis factor alpha (TNF alpha) may play a role in the pathogenesis of Behçet's disease (BD)...
  30. Aytekin C, Dogu F, Ikinciogullari A, Egin Y, Yuksek M, Bozdogan G, et al. [TGF-Beta1-915G/C and TNF-alpha-308G/A polymorphisms in children with asthma]. Tuberk Toraks. 2009;57:62-7 pubmed
  31. Gonzalez S, Martinez Borra J, Lopez Vazquez A, Garcia Fernandez S, Torre Alonso J, Lopez Larrea C. MICA rather than MICB, TNFA, or HLA-DRB1 is associated with susceptibility to psoriatic arthritis. J Rheumatol. 2002;29:973-8 pubmed
    ..oligonucleotides to determine HLA-B, and PCR restriction fragment length polymorphism for tumor necrosis factor-alpha promoter polymorphisms at positions -238 and -308...
  32. Tanaka G, Sandford A, Burkett K, Connett J, Anthonisen N, Pare P, et al. Tumour necrosis factor and lymphotoxin A polymorphisms and lung function in smokers. Eur Respir J. 2007;29:34-41 pubmed
    ..In conclusion, these results support the findings of previous studies in late-onset chronic obstructive pulmonary disease in Caucasian populations. ..
  33. Gentile D, Doyle W, Zeevi A, Howe Adams J, Trecki J, Skoner D. Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma. Hum Immunol. 2004;65:347-51 pubmed
    ..DNA was extracted from buccal brushings and assayed for tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), interleukin (IL)-6, IL-10, and transforming growth factor (..
  34. Selvaraj P, Sriram U, Mathan Kurian S, Reetha A, Narayanan P. Tumour necrosis factor alpha (-238 and -308) and beta gene polymorphisms in pulmonary tuberculosis: haplotype analysis with HLA-A, B and DR genes. Tuberculosis (Edinb). 2001;81:335-41 pubmed
  35. Costeas P, Koumouli A, Giantsiou Kyriakou A, Papaloizou A, Koumas L. Th2/Th3 cytokine genotypes are associated with pregnancy loss. Hum Immunol. 2004;65:135-41 pubmed
    ..Our results suggest that abortive events are determined by genetic factors, reflected in the female patient's immunogenetic profile. ..
  36. Garza Gonzalez E, Hold G, Perez Perez G, Bosques Padilla F, Tijerina Menchaca R, Maldonado Garza H, et al. [Role of polymorphism of certain cytokines in gastric cancer in Mexico. Preliminary results]. Rev Gastroenterol Mex. 2003;68:107-12 pubmed
    Interleukin-10, tumor necrosis factor alpha, Interleukin-1 beta and interleukin-1 receptor antagonist cytokines modulate the inflammatory response in presence of Helicobacter pylori...
  37. Gaudet M, Egan K, Lissowska J, Newcomb P, Brinton L, Titus Ernstoff L, et al. Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk. Hum Genet. 2007;121:483-90 pubmed
    b>Tumor necrosis factor (TNF) is critical to regulation of inflammation. Genetic variation in the promoter region of TNF has been associated with expression differences, and a range of auto-immune, infectious, and oncologic diseases...
  38. Wang M, Helzlsouer K, Smith M, Hoffman Bolton J, Clipp S, Grinberg V, et al. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. Prostate. 2009;69:874-85 pubmed publisher
    ..Although none of the SNPs in the obesity genes tested was associated, this does not rule out a complex role of obesity and its metabolic consequences in prostate cancer etiology. ..
  39. Tachado S, Zhang J, Zhu J, Patel N, Koziel H. HIV impairs TNF-alpha release in response to Toll-like receptor 4 stimulation in human macrophages in vitro. Am J Respir Cell Mol Biol. 2005;33:610-21 pubmed
    ..Inhibition of cellular phosphatases may serve as a potential therapeutic target in the management of bacterial pneumonia in HIV+ persons. ..
  40. Singh H, Jain M, Sachan R, Mittal B. Association of TNFA (-308G>A) and IL-10 (-819C>T) promoter polymorphisms with risk of cervical cancer. Int J Gynecol Cancer. 2009;19:1190-4 pubmed publisher
    ..Pro and anti-inflammatory cytokines (tumor necrosis factor alpha, TNFA and interleukin, IL-10) are involved in fighting against the tumorigenesis...
  41. Quiñones Lombraña A, Lopez Soto A, Ballina Garcia F, Alperi López M, Queiro Silva R, Lopez Vazquez A, et al. BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility. J Rheumatol. 2008;35:741-4 pubmed
    ..The role of BAT1 in the regulation of tumor necrosis factor-a suggests that BAT1 may regulate the inflammatory response observed in patients with RA.
  42. Ibrahim A, Abdel Rahman H, Khorshied M, Sami R, Nasr N, Khorshid O. Tumor necrosis factor alpha-308 and Lymphotoxin alpha+252 genetic polymorphisms and the susceptibility to non-Hodgkin lymphoma in Egypt. Leuk Res. 2012;36:694-8 pubmed publisher
    Genetic polymorphism within the regulatory regions of tumor necrosis factor-alpha (TNF-?) and Lymphotoxin-alpha (LT-?) may be involved in the development of lymphoid malignancies...
  43. Garnacho Montero J, Aldabo Pallas T, Garnacho Montero C, Cayuela A, Jimenez R, Barroso S, et al. Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis. Crit Care. 2006;10:R111 pubmed
    ..The three polymorphisms evaluated in the present study appear not to influence the outcome of patients admitted to the hospital with sepsis. ..
  44. Goldberg M, Han Y, Yan C, Shaw M, Garner W. TNF-alpha suppresses alpha-smooth muscle actin expression in human dermal fibroblasts: an implication for abnormal wound healing. J Invest Dermatol. 2007;127:2645-55 pubmed
    ..and mechanical performance of the collagen matrix under tissue growth factor-beta (TGF-beta) and tumor necrosis factor-alpha (TNF-alpha) stimulation...
  45. Ivansson E, Juko Pecirep I, Gyllensten U. Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer. Gynecol Oncol. 2010;116:544-8 pubmed publisher
    ..The opposite associations in the two populations could then be explained by differences in linkage disequilibrium and population structure. ..
  46. Cardelli M, Cavallone L, Marchegiani F, Oliveri F, Dato S, Montesanto A, et al. A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism. J Gerontol A Biol Sci Med Sci. 2008;63:454-60 pubmed
    The (A/G)-308 polymorphism of the tumor necrosis factor alpha gene (TNF) is associated with age-related diseases, but its influence on longevity is controversial...
  47. Vejbaesya S, Luangtrakool P, Luangtrakool K, Kalayanarooj S, Vaughn D, Endy T, et al. TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais. J Infect Dis. 2009;199:1442-8 pubmed publisher
    ..virus (DENV) infection is characterized by a cascade of cytokine production, including the production of tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha (LT-alpha)...
  48. Yamada Y, Metoki N, Yoshida H, Satoh K, Ichihara S, Kato K, et al. Genetic risk for ischemic and hemorrhagic stroke. Arterioscler Thromb Vasc Biol. 2006;26:1920-5 pubmed
    ..the -55C-->T polymorphism of the uncoupling protein 3 gene (UCP3), the -863C-->A polymorphism of the tumor necrosis factor (TNF) gene (TNF), and the G-->A (Gly243Asp) polymorphism of the polycystic kidney disease 1-like gene (..
  49. Yang S, Lee S, Cho Y, Lim J, Lee I, Song K. Association of TNF-alpha/LTA polymorphisms with Crohn's disease in Koreans. Cytokine. 2006;35:13-20 pubmed
    Polymorphisms of the proinflammatory and immunoregulatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha (LTA), have been shown to affect their production and be associated with Crohn's disease...
  50. Sadowsky D, Adams K, Gravett M, Witkin S, Novy M. Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model. Am J Obstet Gynecol. 2006;195:1578-89 pubmed publisher
    ..days) received 1 of 5 intraamniotic infusions: (1) interleukin-1beta (IL-1beta) (10 microg; n = 5), (2) tumor necrosis factor-alpha (TNF-alpha) (10-100 microg; n = 5), (3) IL-6 (20 microg twice a day; n = 2), (4) IL-8 (20 microg ..
  51. Petersen S, Wang L, Yalcin Chin A, Li L, Peyton M, Minna J, et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell. 2007;12:445-56 pubmed
    ..This signal has now been identified as the autocrine-secreted cytokine tumor necrosis factor alpha (TNFalpha)...
  52. Rodriguez A, Gomez Ambrosi J, Catalan V, Rotellar F, Valenti V, Silva C, et al. The ghrelin O-acyltransferase-ghrelin system reduces TNF-?-induced apoptosis and autophagy in human visceral adipocytes. Diabetologia. 2012;55:3038-50 pubmed publisher
    ..Apoptosis and autophagy are upregulated in human visceral adipose tissue of patients with type 2 diabetes. Acylated and desacyl ghrelin reduce TNF-?-induced apoptosis and autophagy in human visceral adipocytes. ..
  53. Kamali Sarvestani E, Zolghadri J, Gharesi Fard B, Sarvari J. Cytokine gene polymorphisms and susceptibility to recurrent pregnancy loss in Iranian women. J Reprod Immunol. 2005;65:171-8 pubmed
    ..51, 95% CI: 0.3-0.85; p<0.01). There was no significant association with other positions. It may be concluded that IL-10 polymorphism at position -592 could be a genetic factor for RPL. ..
  54. Zabaleta J, Lin H, Sierra R, Hall M, Clark P, Sartor O, et al. Interactions of cytokine gene polymorphisms in prostate cancer risk. Carcinogenesis. 2008;29:573-8 pubmed publisher
    ..92, 95% CI = 1.13-7.55) and the genotype combination of TNF-238GG plus IL10-592AA (OR = 2.14, 95% CI = 1.05-4.38). Our results highlight the importance of cytokine SNPs and their interactions in CaP risk. ..
  55. Dufour C, Corcione A, Svahn J, Haupt R, Poggi V, Béka ssy A, et al. TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro. Blood. 2003;102:2053-9 pubmed
    In Fanconi anemia (FA) C mice tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) have key roles in the pathogenesis of bone marrow failure...
  56. Duell E, Casella D, Burk R, Kelsey K, Holly E. Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15:726-31 pubmed
    ..There was no overall association between pancreatic cancer risk and tumor necrosis factor-alpha (TNF-A -308G/A), regulated upon activation, normally T cell-expressed, and presumably secreted (..
  57. Skibola C, Bracci P, Nieters A, Brooks Wilson A, de Sanjose S, Hughes A, et al. Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium. Am J Epidemiol. 2010;171:267-76 pubmed publisher
    ..Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk...