TNC

Summary

Gene Symbol: TNC
Description: tenascin C
Alias: 150-225, DFNA56, GMEM, HXB, TN-C, tenascin, GP 150-225, cytotactin, deafness, autosomal dominant 56, glioma-associated-extracellular matrix antigen, hexabrachion (tenascin), myotendinous antigen, neuronectin, tenascin-C additional domain 1, tenascin-C isoform 14/AD1/16
Species: human
Products:     TNC

Top Publications

  1. Siri A, Carnemolla B, Saginati M, Leprini A, Casari G, Baralle F, et al. Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. Nucleic Acids Res. 1991;19:525-31 pubmed
    By sequencing cDNA clones which cover the complete coding region of human tenascin (TN), we have established its primary structure...
  2. Sriramarao P, Mendler M, Bourdon M. Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins. J Cell Sci. 1993;105 ( Pt 4):1001-12 pubmed
    Human umbilical vein endothelial cells were found to attach and partially spread on human tenascin. The attachment of endothelial cells to tenascin results in elongated cells with interconnecting processes and is distinct from the ..
  3. Huang J, Cheng Y, Lin Y, Lin H, Su C, Juliano R, et al. Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression. J Immunol. 2010;185:1450-9 pubmed publisher
    ..Glioma cells, but not MCF-7 and HepG2 cells, expressed tenascin-C...
  4. Chung C, Zardi L, Erickson H. Binding of tenascin-C to soluble fibronectin and matrix fibrils. J Biol Chem. 1995;270:29012-7 pubmed
    The small splice variant of tenascin-C (TN) has eight fibronectin type III (FN3) domains. The major large splice variant has three (in chicken) or seven (in human) additional FN3 domains inserted between domains five and six...
  5. Yokosaki Y, Palmer E, Prieto A, Crossin K, Bourdon M, Pytela R, et al. The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. J Biol Chem. 1994;269:26691-6 pubmed
    ..to mock transfectants, both 293 cells and SW480 cells expressing alpha 9 beta 1 adhered to intact chicken tenascin. By utilizing a variety of recombinant fragments of tenascin, we were able to localize the binding site for alpha ..
  6. Ilmonen S, Jahkola T, Turunen J, Muhonen T, Asko Seljavaara S. Tenascin-C in primary malignant melanoma of the skin. Histopathology. 2004;45:405-11 pubmed
    To investigate the expression and the prognostic role of glycoprotein Tenascin-C (Tn-C) in primary melanoma of the skin...
  7. Goh F, Piccinini A, Krausgruber T, Udalova I, Midwood K. Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation. J Immunol. 2010;184:2655-62 pubmed publisher
    ..The extracellular matrix glycoprotein tenascin-C is an endogenous activator of innate immunity that promotes the synthesis of inflammatory cytokines via ..
  8. Jones P, Crack J, Rabinovitch M. Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J Cell Biol. 1997;139:279-93 pubmed
    b>Tenascin-C (TN-C) is induced in pulmonary vascular disease, where it colocalizes with proliferating smooth muscle cells (SMCs) and epidermal growth factor (EGF)...
  9. Prieto A, Edelman G, Crossin K. Multiple integrins mediate cell attachment to cytotactin/tenascin. Proc Natl Acad Sci U S A. 1993;90:10154-8 pubmed
    To identify potential cell surface receptors for chicken cytotactin (CT), we have characterized the ability of recombinant fusion proteins spanning the proximal fibronectin (FN) type III repeats of the molecule to support attachment of ..

More Information

Publications90

  1. Cai M, Onoda K, Takao M, Kyoko I, Shimpo H, Yoshida T, et al. Degradation of tenascin-C and activity of matrix metalloproteinase-2 are associated with tumor recurrence in early stage non-small cell lung cancer. Clin Cancer Res. 2002;8:1152-6 pubmed
    ..factor for early stage non-small cell lung cancer (NSCLC), we examined the relationship of the degree of tenascin-C (TN-C) degradation in relapsed NSCLC tumors with the prognosis of the patients...
  2. Swindle C, Tran K, Johnson T, Banerjee P, Mayes A, Griffith L, et al. Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. J Cell Biol. 2001;154:459-68 pubmed
    ..a new class of ligand for the epidermal growth factor (EGF) receptor (EGFR) found within the EGF-like repeats of tenascin-C, an antiadhesive matrix component present during organogenesis, development, and wound repair...
  3. Sriramarao P, Bourdon M. A novel tenascin type III repeat is part of a complex of tenascin mRNA alternative splices. Nucleic Acids Res. 1993;21:163-8 pubmed
    Sequence analysis of two human tenascin encoding cDNA clones from a cDNA library of the U251 glioblastoma cell line revealed the presence of a novel 276 bp tenascin type III fibronectin like repeat...
  4. Wang Y, Man Y, Ding Y, Ma B, Qiu X, Fan Q, et al. Mechanical strain and growth factors regulate expression of tenascin-C by OS cells additively. Oncol Res. 2013;20:509-16 pubmed publisher
    Osteosarcoma (OS) is a kind of malignancy wherein the tumor cells form malignant bone-like or bone tissue. Tenascin-C (TN-C), an important extracellular matrix (ECM) protein, plays an indispensable role in tumor development...
  5. Lange K, Kammerer M, Saupe F, Hegi M, Grotegut S, Fluri E, et al. Combined lysophosphatidic acid/platelet-derived growth factor signaling triggers glioma cell migration in a tenascin-C microenvironment. Cancer Res. 2008;68:6942-52 pubmed publisher
    The antiadhesive extracellular matrix molecule tenascin-C abrogates cell spreading on fibronectin through competitive inhibition of syndecan-4, thereby preventing focal adhesion kinase (FAK) activation and triggering enhanced proteolytic ..
  6. Kaarteenaho Wiik R, Sademies O, Paakko P, Risteli J, Soini Y. Extracellular matrix proteins and myofibroblasts in granulomas of sarcoidosis, atypical mycobacteriosis, and tuberculosis of the lung. Hum Pathol. 2007;38:147-53 pubmed
    ..The structure of granulomas has not been elucidated completely. We studied the expression of tenascin-C, precursor proteins of collagens I and III, and the presence of myofibroblasts in granulomas of sarcoidosis, ..
  7. Hancox R, Allen M, Holliday D, Edwards D, Pennington C, Guttery D, et al. Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms. Breast Cancer Res. 2009;11:R24 pubmed publisher
    ..The ECM protein tenascin-C (TNC) is frequently up-regulated in breast cancer and we have previously identified two novel isoforms - one ..
  8. Ballard V, Sharma A, Duignan I, Holm J, Chin A, Choi R, et al. Vascular tenascin-C regulates cardiac endothelial phenotype and neovascularization. FASEB J. 2006;20:717-9 pubmed
    ..pathways, in vivo bone marrow/cardiac phage display biopanning was performed and led to the identification of tenascin-C as a candidate protein...
  9. Jang J, Chung C. Tenascin-C promotes cell survival by activation of Akt in human chondrosarcoma cell. Cancer Lett. 2005;229:101-5 pubmed
    b>Tenascin-C (TnC) is an extracellular matrix protein that is highly expressed in tumor stroma. In this report, we examined the roles of TnC-mediated cell adhesion in the modulation of chondrosarcoma cell survival...
  10. Midwood K, Sacre S, Piccinini A, Inglis J, Trebaul A, Chan E, et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med. 2009;15:774-80 pubmed publisher
    ..b>Tenascin-C (encoded by Tnc) is an extracellular matrix glycoprotein specifically expressed at areas of inflammation and ..
  11. Wallner K, Li C, Shah P, Wu K, Schwartz S, Sharifi B. EGF-Like domain of tenascin-C is proapoptotic for cultured smooth muscle cells. Arterioscler Thromb Vasc Biol. 2004;24:1416-21 pubmed
    Based on our previous observations on the expression of Tenascin-C (Tn-C) in human atherosclerotic plaques and its colocalization with macrophages, we explored whether Tn-C undergoes fragmentation and the potential pathobiological ..
  12. Imanaka Yoshida K, Hiroe M, Yoshida T. Interaction between cell and extracellular matrix in heart disease: multiple roles of tenascin-C in tissue remodeling. Histol Histopathol. 2004;19:517-25 pubmed publisher
    ..Among various ECM molecules, tenascin-C (TNC) is well known as a regulator of multiple cellular functions during embryogenesis, wound healing or cancer ..
  13. Kaarteenaho Wiik R, Kinnula V, Herva R, Soini Y, Pöllänen R, Paakko P. Tenascin-C is highly expressed in respiratory distress syndrome and bronchopulmonary dysplasia. J Histochem Cytochem. 2002;50:423-31 pubmed
    b>Tenascin-C is an extracellular matrix (ECM) glycoprotein expressed in human tissues during organogenesis and in fibrotic and neoplastic processes...
  14. Wenk M, Midwood K, Schwarzbauer J. Tenascin-C suppresses Rho activation. J Cell Biol. 2000;150:913-20 pubmed
    ..b>Tenascin-C, a developmentally regulated matrix protein, modulates cellular responses to other matrix proteins, such as ..
  15. To W, Midwood K. Cryptic domains of tenascin-C differentially control fibronectin fibrillogenesis. Matrix Biol. 2010;29:573-85 pubmed publisher
    ..b>Tenascin-C is a matrix protein with a restricted expression pattern; it is specifically up-regulated at sites of ..
  16. Nakoshi Y, Hasegawa M, Sudo A, Yoshida T, Uchida A. Regulation of tenascin-C expression by tumor necrosis factor-alpha in cultured human osteoarthritis chondrocytes. J Rheumatol. 2008;35:147-52 pubmed
    Expression of tenascin-C reappears in articular cartilage of persons with osteoarthritis (OA), while it is almost abolished in normal mature cartilage...
  17. Saito Y, Imazeki H, Miura S, Yoshimura T, Okutsu H, Harada Y, et al. A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4. J Biol Chem. 2007;282:34929-37 pubmed
    b>Tenascin-C (TN-C) is unique for its cell adhesion modulatory function...
  18. Iyer A, Tran K, Borysenko C, Cascio M, Camacho C, Blair H, et al. Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity. J Cell Physiol. 2007;211:748-58 pubmed
    Select epidermal growth factor (EGF)-like (EGFL) repeats of human tenascin cytotactin (tenascin C) can stimulate EGF receptor (EGFR) signaling, but activation requires micromolar concentrations of soluble EGFL repeats in contrast to ..
  19. Chen J, Chen Z, Chen M, Li D, Li Z, Xiong Y, et al. Role of fibrillar Tenascin-C in metastatic pancreatic cancer. Int J Oncol. 2009;34:1029-36 pubmed
    ..In the tumor, upregulation of Tenascin-C (Tn-C) expression potentially can alter tumor behavior...
  20. Fukunaga Kalabis M, Martinez G, Nguyen T, Kim D, Santiago Walker A, Roesch A, et al. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene. 2010;29:6115-24 pubmed publisher
    b>Tenascin-C (TNC) is highly expressed in melanoma; however, little is known about its functions. Recent studies indicate that TNC has a role within the stem cell niche...
  21. Hirata E, Arakawa Y, Shirahata M, Yamaguchi M, Kishi Y, Okada T, et al. Endogenous tenascin-C enhances glioblastoma invasion with reactive change of surrounding brain tissue. Cancer Sci. 2009;100:1451-9 pubmed publisher
    b>Tenascin-C is an extracellular matrix glycoprotein implicated in embryogenesis, wound healing and tumor progression. We previously revealed that tenascin-C expression is correlated with the prognosis of patients with glioblastoma...
  22. Puente Navazo M, Valmori D, Ruegg C. The alternatively spliced domain TnFnIII A1A2 of the extracellular matrix protein tenascin-C suppresses activation-induced T lymphocyte proliferation and cytokine production. J Immunol. 2001;167:6431-40 pubmed
    ..We have previously shown that tenascin-C, an extracellular matrix protein highly expressed in the tumor stroma, inhibits T lymphocyte activation in ..
  23. De Wever O, Nguyen Q, Van Hoorde L, Bracke M, Bruyneel E, Gespach C, et al. Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J. 2004;18:1016-8 pubmed
    ..scatter factor/hepatocyte growth factor (SF/HGF) and the TGF-beta-upregulated extracellular matrix glycoprotein tenascin-C (TNC), each of which is necessary though not sufficient for invasion...
  24. Pazzaglia L, Conti A, Chiechi A, Novello C, Magagnoli G, Astolfi A, et al. Differential gene expression in classic giant cell tumours of bone: Tenascin C as biological risk factor for local relapses and metastases. Histopathology. 2010;57:59-72 pubmed publisher
    ..A correlation was found between mRNA levels and clinical outcome identifying Tenascin C (TNC) as the most significant prognostic biological marker...
  25. Tsunoda T, Inada H, Kalembeyi I, Imanaka Yoshida K, Sakakibara M, Okada R, et al. Involvement of large tenascin-C splice variants in breast cancer progression. Am J Pathol. 2003;162:1857-67 pubmed
    Alternative splicing of fibronectin-like type III (FNIII) repeats of tenascin-C (Tn-C) generates a number of splice variants...
  26. Lukacs M, Warfvinge K, Tajti J, Fulop F, Toldi J, Vecsei L, et al. Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72). J Headache Pain. 2017;18:39 pubmed publisher
    ..Activation in the trigeminal nucleus caudalis (TNC) and the trigeminal tract (Sp5) was achieved by application of CFA onto the dural parietal surface...
  27. Pravenec M, Zidek V, Landa V, Mlejnek P, Silhavy J, Simakova M, et al. Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity. Physiol Res. 2017;66:917-924 pubmed
    ..Recent linkage analysis in the BXH/HXB recombinant inbred (RI) strains, derived from Brown Norway (BN) and spontaneously hypertensive rats (SHR), ..
  28. Ambort D, Brellier F, Becker Pauly C, Stöcker W, Andrejevic Blant S, Chiquet M, et al. Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading. Matrix Biol. 2010;29:31-42 pubmed publisher
    ..Here, we investigated the susceptibility of tenascin-C to cleavage by meprinbeta and the functional properties of its proteolytic fragments...
  29. Zhang X, Zhang W, Dong C, Hu W, Sun Y, Bao Y, et al. Analgesia effect of baicalein against NTG-induced migraine in rats. Biomed Pharmacother. 2017;90:116-121 pubmed publisher
    ..In addition, immunohistochemistry was applied to detect c-Fos neuronal activity in trigeminal nucleus caudalis (TNC). Behavioral research showed that BAI administration alleviated the hyperalgesia in migraine rats...
  30. Doronin D, Barykina N, Subach O, Sotskov V, Plusnin V, Ivleva O, et al. Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics. BMC Biotechnol. 2018;18:10 pubmed publisher
    ..calcium indicator (GECI), called NTnC, has a novel design with reduced size due to utilization of the troponin C (TnC) as a Ca2+-binding moiety inserted into the mNeonGreen fluorescent protein...
  31. Wabik J, Kurcinski M, Kolinski A. Coarse-Grained Modeling of Peptide Docking Associated with Large Conformation Transitions of the Binding Protein: Troponin I Fragment-Troponin C System. Molecules. 2015;20:10763-80 pubmed publisher
    ..In an example application we modeled the process of complex assembly between two proteins: Troponin C (TnC) and the N-terminal helix of Troponin I (TnI N-helix), which occurs in vivo during muscle contraction...
  32. Uenishi G, Theisen D, Lee J, Kumar A, Raymond M, Vodyanik M, et al. Tenascin C promotes hematoendothelial development and T lymphoid commitment from human pluripotent stem cells in chemically defined conditions. Stem Cell Reports. 2014;3:1073-84 pubmed publisher
    ..defined conditions required to produce HE from hPSCs growing in Essential 8 (E8) medium and showed that Tenascin C (TenC), an extracellular matrix protein associated with HSC niches, strongly promotes HE and definitive ..
  33. Tsai H, Chiu W, Fang C, Hwang S, Renshaw P, Lai W. Different forms of tenascin-C with tenascin-R regulate neural differentiation in bone marrow-derived human mesenchymal stem cells. Tissue Eng Part A. 2014;20:1908-21 pubmed publisher
    ..Studies have reported that the tenascin family members, tenascin-C (TnC) and tenascin-R (TnR), regulate differentiation and migration, in addition to ..
  34. Reinhard J, Roll L, Faissner A. Tenascins in Retinal and Optic Nerve Neurodegeneration. Front Integr Neurosci. 2017;11:30 pubmed publisher
    ..Additionally, tenascin-C (Tnc) represents a key modulator of the immune system and inflammatory processes...
  35. Veres G, Fejes Szabó A, Zadori D, Nagy Grócz G, Laszlo A, Bajtai A, et al. A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study. J Neural Transm (Vienna). 2017;124:99-112 pubmed publisher
    ..Thereafter, the rubbing activity and c-Fos immunoreactivity changes in the spinal trigeminal nucleus pars caudalis (TNC) were investigated...
  36. Verrando P, Capovilla M, Rahmani R. Trans-nonachlor decreases miR-141-3p levels in human melanocytes in vitro promoting melanoma cell characteristics and shows a multigenerational impact on miR-8 levels in Drosophila. Toxicology. 2016;368-369:129-141 pubmed publisher
    ..Based on epidemiological studies of melanoma, our data show for the first time that trans-nonachlor (TNC), a component of the pesticide chlordane, modulates the microRNA miR-141-3p in human melanocytic cells in vitro, ..
  37. Mansour R, Stamper L, Jaeger F, McGuire E, Fouda G, Amos J, et al. The Presence and Anti-HIV-1 Function of Tenascin C in Breast Milk and Genital Fluids. PLoS ONE. 2016;11:e0155261 pubmed publisher
    b>Tenascin-C (TNC) is a newly identified innate HIV-1-neutralizing protein present in breast milk, yet its presence and potential HIV-inhibitory function in other mucosal fluids is unknown...
  38. Deweese R, Slavens J, Barua A, Sutton J. Vancomycin-induced eosinophilic peritonitis. Am J Health Syst Pharm. 2016;73:e243-6 pubmed publisher
    ..of peripheral blood and peritoneal fluid analyses showing highly elevated neutrophil and total nucleated cell (TNC) counts...
  39. Vences M, Guayasamin J, Miralles A, De la Riva I. To name or not to name: Criteria to promote economy of change in Linnaean classification schemes. Zootaxa. 2013;3636:201-44 pubmed
    ..We provide a rationale for each TNC along with real and theoretical examples to illustrate their practical advantages and disadvantages...
  40. Trescher K, Thometich B, Demyanets S, Kassal H, Sedivy R, Bittner R, et al. Type A dissection and chronic dilatation: tenascin-C as a key factor in destabilization of the aortic wall. Interact Cardiovasc Thorac Surg. 2013;17:365-70 pubmed publisher
    b>Tenascin-C plays an important role in myocardial and vascular remodelling...
  41. Liu R, He Y, Li B, Liu J, Ren Y, Han W, et al. Tenascin-C produced by oxidized LDL-stimulated macrophages increases foam cell formation through Toll-like receptor-4. Mol Cells. 2012;34:35-41 pubmed publisher
    ..Here, we show that tenascin-C (TN-C) can stimulate foam cell formation and this can be inhibited by a TLR4-blocking antibody or CD36 gene ..
  42. Wang R, Li Z, Han X, Li B, Mi X, Sun L, et al. Integrin ?3 and its ligand regulate the expression of uPA through p38 MAPK in breast cancer. APMIS. 2010;118:909-17 pubmed publisher
    ..The aim of the study was to determine the combined expression of integrin ?3 and tenascin-c (TN-c) in breast cancer and examine whether integrin ?3 and TN-c can activate urokinase-type plasminogen ..
  43. Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N, et al. Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem. 2010;285:2028-39 pubmed publisher
    ..Here we show that periostin, a matricellular protein, promotes incorporation of tenascin-C into the ECM and organizes a meshwork architecture of the ECM...
  44. Mitamura Y, Takeuchi S, Ohtsuka K, Matsuda A, Hiraiwa N, Kusakabe M. Tenascin-C levels in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Care. 2002;25:1899 pubmed
  45. Sis B, Sagol O, Kupelioglu A, Sokmen S, Terzi C, Fuzun M, et al. Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma. Pathol Res Pract. 2004;200:379-87 pubmed
    ..play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment...
  46. Jachetti E, Caputo S, Mazzoleni S, Brambillasca C, Parigi S, Grioni M, et al. Tenascin-C Protects Cancer Stem-like Cells from Immune Surveillance by Arresting T-cell Activation. Cancer Res. 2015;75:2095-108 pubmed publisher
    ..CSC derived from either PDLN or mPIN used the extracellular matrix protein Tenascin-C (TNC) to inhibit T-cell receptor-dependent T-cell activation, proliferation, and cytokine production...
  47. Chan J, Greenfield S, Soukup D, Do H, Deland J, Ellis S. Contribution of Lateral Column Lengthening to Correction of Forefoot Abduction in Stage IIb Adult Acquired Flatfoot Deformity Reconstruction. Foot Ankle Int. 2015;36:1400-11 pubmed publisher
    ..after surgery were reviewed to determine correction in forefoot abduction as measured by talonavicular coverage (TNC) angle, talonavicular uncoverage percent, talus-first metatarsal (T-1MT) angle, and lateral incongruency angle...
  48. Kaur I, Zulovich J, Gonzalez M, McGee K, Ponweera N, Thandi D, et al. Comparison of two methodologies for the enrichment of mononuclear cells from thawed cord blood products: The automated Sepax system versus the manual Ficoll method. Cytotherapy. 2017;19:433-439 pubmed publisher
    ..Using Sepax, we observed higher recovery of total nucleated cells (TNC), CD34+ cells, NK cells and monocytes when compared to manual enrichment, despite similar TNC and CD34<..
  49. Etzold A, Galetzka D, Weis E, Bartsch O, Haaf T, Spix C, et al. CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue. Epigenetics. 2016;11:120-31 pubmed publisher
    ..genes known to be key markers of so called cancer-associated fibroblasts (CAFs), such as ACTA2, FAP, PDPN, and TNC, were upregulated in fibroblasts of the affected twin (BRCA1(mosMe)) in comparison to those of the healthy twin (..
  50. Ljubimov A, Saghizadeh M, Pytela R, Sheppard D, Kenney M. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. J Histochem Cytochem. 2001;49:1341-50 pubmed
    We previously found an abnormal deposition of an extracellular matrix glycoprotein, tenascin-C (TN-C), in human corneas with pseudophakic/aphakic bullous keratopathy (PBK/ABK)...
  51. Murakami T, Kikuchi H, Ishimatsu H, Iino I, Hirotsu A, Matsumoto T, et al. Tenascin C in colorectal cancer stroma is a predictive marker for liver metastasis and is a potent target of miR-198 as identified by microRNA analysis. Br J Cancer. 2017;117:1360-1370 pubmed publisher
    ..Combinatory target prediction identified tenascin C as a predicted target of miR-198, one of the top 10 miRNAs downregulated in tumour stroma of CRCs with ..
  52. Lange K, Kammerer M, Hegi M, Grotegut S, Dittmann A, Huang W, et al. Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization. Cancer Res. 2007;67:6163-73 pubmed
    b>Tenascin-C, an extracellular matrix molecule of the tumor-specific microenvironment, counteracts the tumor cell proliferation-suppressing effect of fibronectin by blocking the integrin alpha(5)beta(1)/syndecan-4 complex...
  53. Grahovac J, Becker D, Wells A. Melanoma cell invasiveness is promoted at least in part by the epidermal growth factor-like repeats of tenascin-C. J Invest Dermatol. 2013;133:210-20 pubmed publisher
    b>Tenascin-C (TNC), overexpressed in invasive growths, has been implicated in progression of melanoma, but the source and function of this molecule are not well defined...
  54. Abdou A, Maraee A, Shoeib M, Elbana R. Immunolocalization of tenascin-C in vitiligo. Appl Immunohistochem Mol Morphol. 2012;20:501-11 pubmed publisher
    ..The disappearance of melanocytes because of defective adhesion is one of the accepted theories to explain vitiligo. Tenascin-C is a large, extracellular matrix glycoprotein that is thought to inhibit adhesion of melanocytes to fibronectin...
  55. Tanaka R, Seki Y, Saito Y, Kamiya S, Fujita M, Okutsu H, et al. Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin ?5?1. J Biol Chem. 2014;289:17699-708 pubmed publisher
    b>Tenascin-C is an adhesion modulatory matrix protein that is highly expressed in tumors; however, its biochemical activity involved in tumorigenesis is not fully understood...
  56. Dang D, Atakilit A, Ramos D. EMMPRIN modulates migration and deposition of TN-C in oral squamous carcinoma. Anticancer Res. 2008;28:2049-54 pubmed
    ..Cocultures of SCC/peritumor fibroblasts (PTF) were used to investigate tenascin-C (TN-C) matrix deposition...
  57. Ihida Stansbury K, McKean D, Lane K, Loyd J, Wheeler L, Morrell N, et al. Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2006;291:L694-702 pubmed
    ..Here we show that pulmonary vascular lesions from patients harboring BMPR2 mutations express high levels of tenascin-C (TN-C), an extracellular matrix glycoprotein that promotes pulmonary artery (PA) smooth muscle cell (SMC) ..
  58. Fujimoto M, Shiba M, Kawakita F, Liu L, Nakasaki A, Shimojo N, et al. Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats. Brain Res. 2016;1642:436-444 pubmed publisher
    b>Tenascin-C (TNC), one of matricellular proteins, has been suggested to be involved in cerebral vasospasm after aneurysmal subarachnoid hemorrhage. However, the mechanisms of how TNC constricts cerebral arteries remain unclear...
  59. Kobayashi Y, Yoshida S, Zhou Y, Nakama T, Ishikawa K, Kubo Y, et al. Tenascin-C secreted by transdifferentiated retinal pigment epithelial cells promotes choroidal neovascularization via integrin αV. Lab Invest. 2016;96:1178-1188 pubmed publisher
    b>Tenascin-C is expressed in choroidal neovascular (CNV) membranes in eyes with age-related macular degeneration (AMD). However, its role in the pathogenesis of CNV remains to be elucidated...
  60. Miroshnikova Y, Mouw J, Barnes J, Pickup M, Lakins J, Kim Y, et al. Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016;18:1336-1345 pubmed publisher
    ..We found that glioma aggression and patient prognosis correlate with HIF1α levels and the stiffness of a tenascin C (TNC)-enriched ECM...
  61. Schnapp L, Hatch N, Ramos D, Klimanskaya I, Sheppard D, Pytela R. The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. J Biol Chem. 1995;270:23196-202 pubmed
    ..vitronectin adhesion appeared to be mediated by RGD, we examined additional RGD-containing proteins, including tenascin, fibrinogen, thrombospondin, osteopontin, and denatured collagen type I...
  62. Gherzi R, Carnemolla B, Siri A, Ponassi M, Balza E, Zardi L. Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences. J Biol Chem. 1995;270:3429-34 pubmed
    This report describes the genomic organization of the 5'-region of the human tenascin-C (TN) gene and the functional characterization of its promoter...
  63. Anderson J, Seol H, Gordish Dressman H, Hathout Y, Spurney C. Interleukin 1 Receptor-Like 1 Protein (ST2) is a Potential Biomarker for Cardiomyopathy in Duchenne Muscular Dystrophy. Pediatr Cardiol. 2017;38:1606-1612 pubmed publisher
    ..01). Among a selected set of potential biomarkers for cardiomyopathy (MMP9, BNP, GAL3, CRP, LEP, TNC, TLR4 and ST2) we validated ST2 as significantly elevated in the serum of DMD cardiomyopathy group (35,798 ± ..
  64. Matsuo T, Tominaga T, Kono F, Shibata K, Fujiwara S. Modulation of the picosecond dynamics of troponin by the cardiomyopathy-causing mutation K247R of troponin T observed by quasielastic neutron scattering. Biochim Biophys Acta Proteins Proteom. 2017;1865:1781-1789 pubmed publisher
    Troponin (Tn), consisting of three subunits (TnC, TnI, and TnT), regulates cardiac muscle contraction in a Ca2+-dependent manner...
  65. Jakovcevski I, Miljkovic D, Schachner M, Andjus P. Tenascins and inflammation in disorders of the nervous system. Amino Acids. 2013;44:1115-27 pubmed publisher
    In vitro and in vivo studies on the role of tenascins have shown that the two paradigmatic glycoproteins of the tenascin family, tenascin-C (TnC) and tenascin-R (TnR) play important roles in cell proliferation and migration, fate ..
  66. Rauch U, Clement A, Retzler C, Frohlich L, Fassler R, Göhring W, et al. Mapping of a defined neurocan binding site to distinct domains of tenascin-C. J Biol Chem. 1997;272:26905-12 pubmed
    ..complementary ligands of neurocan, the COOH-terminal neurocan domain was fused with the NH2-terminal region of tenascin-C, which contains the hexamerization domain of this extracellular matrix glycoprotein...
  67. Kanayama M, Morimoto J, Matsui Y, Ikesue M, Danzaki K, Kurotaki D, et al. ?9?1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. J Immunol. 2011;187:5851-64 pubmed publisher
    The interaction between matricellular proteins such as tenascin-C (TN-C) and osteopontin (OPN) and integrins has been implicated in the pathology of rheumatoid arthritis in which Th17 cells are recognized as primary pathogenic cells...
  68. Goepel C, Stoerer S, Koelbl H. Tenascin in preinvasive lesions of the vulva and vulvar cancer. Anticancer Res. 2003;23:4587-91 pubmed
    ..In this study we investigated normal, preinvasive and invasive vulvar tissues to look for relevant changes of Tenascin, a glycoprotein, already detected in pre-invasive and invasive lesions of the breast...
  69. Kul S, Ozcelik H, Uyarel H, Karakus G, Güvenç T, Yalçınsoy M, et al. Diagnostic value of strain echocardiography, galectin-3, and tenascin-C levels for the identification of patients with pulmonary and cardiac sarcoidosis. Lung. 2014;192:533-42 pubmed publisher
    ..We also studied markers of fibrosis (tenascin-C [Tn-C] and galectin-3 [Gl-3]) as diagnostic tools for PS and cardiac sarcoidosis (CS)...
  70. Zagzag D, Friedlander D, Dosik J, Chikramane S, Chan W, Greco M, et al. Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro. Cancer Res. 1996;56:182-9 pubmed
    The expression of the extracellular matrix glycoprotein tenascin-C (TN) is enhanced in human astrocytomas and correlates with angiogenesis...
  71. San Martin R, Pathak R, Jain A, Jung S, Hilsenbeck S, Piña Barba M, et al. Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment. Cancer Res. 2017;77:5977-5988 pubmed publisher
    Deposition of the extracellular matrix protein tenascin-C is part of the reactive stroma response, which has a critical role in prostate cancer progression...
  72. Cai J, Du S, Wang H, Xin B, Wang J, Shen W, et al. Tenascin-C induces migration and invasion through JNK/c-Jun signalling in pancreatic cancer. Oncotarget. 2017;8:74406-74422 pubmed publisher
    b>Tenascin-C (TNC), a large extracellular matrix glycoprotein, has been reported to be associated with metastasis and poor prognosis in pancreatic cancer...
  73. Herold Mende C, Mueller M, Bonsanto M, Schmitt H, Kunze S, Steiner H. Clinical impact and functional aspects of tenascin-C expression during glioma progression. Int J Cancer. 2002;98:362-9 pubmed
    The extracellular matrix protein tenascin-C is expressed in processes like embryogenesis and wound healing and in neoplasia...
  74. Glumoff V, Savontaus M, Vehanen J, Vuorio E. Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes. Biochim Biophys Acta. 1994;1219:613-22 pubmed
    ..cDNA clones for detection of mRNAs for two major noncollagenous macromolecules of cartilage matrix, aggrecan and tenascin. We subsequently determined their corresponding mRNA levels by Northern analysis in a panel of total RNAs ..
  75. Lentini M, Schepis C, Cuppari D, Batolo D. Tenascin expression in actinic keratosis. J Cutan Pathol. 2006;33:716-20 pubmed
    b>Tenascin is an extracellular matrix protein frequently expressed around neoplastic and non-neoplastic lesions of the skin. Actinic keratoses (AKs) are intraepidermal neoplastic lesions of the sun-exposed skin...
  76. Fujimoto N, Onishi K, Sato A, Terasaki F, Tsukada B, Nozato T, et al. Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure. J Card Fail. 2009;15:898-905 pubmed publisher
    This study investigates the predictive value of serum tenascin-C (TN-C), which is observed at the active sites of ongoing tissue remodeling, for cardiac events of patients with dilated cardiomyopathy (DCM)...
  77. Sadej R, Inai K, Rajfur Z, Ostapkowicz A, Kohler J, Skladanowski A, et al. Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells. Biochim Biophys Acta. 2008;1782:35-40 pubmed
    b>Tenascin C is expressed in invasive human solid tumors; however its specific role in cancer biology remains obscure...
  78. Zhao Y, Lou L, Yang K, Wang H, Xu Y, Lu G, et al. Correlation of tenascin-C concentrations in serum with outcome of traumatic brain injury in humans. Clin Chim Acta. 2017;472:46-50 pubmed publisher
    b>Tenascin-C, a matricellular protein, is involved in brain injury. However, change of tenascin-C concentrations in peripheral blood remains unknown after traumatic brain injury (TBI)...
  79. Tsujii M, Hirata H, Yoshida T, Imanaka Yoshida K, Morita A, Uchida A. Involvement of tenascin-C and PG-M/versican in flexor tenosynovial pathology of idiopathic carpal tunnel syndrome. Histol Histopathol. 2006;21:511-8 pubmed publisher
    ..To clarify the role of tenascin-C and PG-M/versican, which have often been found to be involved in tissue remodeling and vascular stenosis in the ..
  80. Song L, Wang L, Li F, Yukht A, Qin M, Ruther H, et al. Bone Marrow-Derived Tenascin-C Attenuates Cardiac Hypertrophy by Controlling Inflammation. J Am Coll Cardiol. 2017;70:1601-1615 pubmed publisher
    b>Tenascin-C (TNC) is a highly conserved matricellular protein with a distinct expression pattern during development and disease...
  81. Celik A. The relationship between tenascin-C levels and the complexity of coronary lesion after myocardial infarction. J Atheroscler Thromb. 2011;18:693-7 pubmed
    The increase of tenascin-C levels after myocardial infarction has been demonstrated by previous studies. The relationship between tenascin-C and the grade of stenosis in the infarct-related coronary artery was indeterminate...