TMPO

Summary

Gene Symbol: TMPO
Description: thymopoietin
Alias: CMD1T, LAP2, LEMD4, PRO0868, LEM domain containing 4, TP alpha, TP beta/gamma, lamina-associated polypeptide 2, thymopoietin-related peptide isoform alpha, thymopoietin-related peptide isoforms beta/gamma
Species: human

Top Publications

  1. ncbi LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction
    K Furukawa
    Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya Japan, 464 8602
    J Cell Sci 112:2485-92. 1999
  2. ncbi Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation
    R Foisner
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
    Cell 73:1267-79. 1993
  3. ncbi The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products
    R Berger
    Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Isreal
    Genome Res 6:361-70. 1996
  4. ncbi The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation
    Raz Somech
    Sheba Cancer Research Center and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    J Cell Sci 118:4017-25. 2005
  5. ncbi HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics
    S B Martins
    Institute of Medical Biochemistry, University of Oslo, PO Box 1112 Blindern, Norway
    J Cell Sci 113:3703-13. 2000
  6. doi Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes
    D W Craig
    Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Diabet Med 26:1090-8. 2009
  7. pmc Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA
    M Cai
    Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0510, USA
    EMBO J 20:4399-407. 2001
  8. pmc Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics
    T Dechat
    nstitute of Biochemistry and Molecular Cell Biology, Biocenter and Institute of Tumor Biology Cancer Research, University of Vienna, A 1030 Vienna, Austria
    EMBO J 17:4887-902. 1998
  9. pmc Three distinct human thymopoietins are derived from alternatively spliced mRNAs
    C A Harris
    Immunobiology Research Institute, Annandale, NJ 08801
    Proc Natl Acad Sci U S A 91:6283-7. 1994
  10. ncbi Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins
    T Dechat
    Department of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Cell Sci 113:3473-84. 2000

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. ncbi LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction
    K Furukawa
    Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya Japan, 464 8602
    J Cell Sci 112:2485-92. 1999
    ..The chromatin- and lamin-binding activity of LAP2 suggests that LAP2 plays an important role in targeting mitotic vesicles to chromosomes and reorganizing the ..
  2. ncbi Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation
    R Foisner
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
    Cell 73:1267-79. 1993
    ..Together, these data suggest that LAP 2 may have a key role in initial events of nuclear envelope reassembly, and that both LAP 2 and LAP 1 may be involved in attaching lamins to the nuclear envelope...
  3. ncbi The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products
    R Berger
    Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Isreal
    Genome Res 6:361-70. 1996
    ..Here we report the isolation and characterization of seven mouse Tmpo mRNA transcripts named Tmpo alpha, beta, beta', gamma, epsilon, delta, and zeta...
  4. ncbi The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation
    Raz Somech
    Sheba Cancer Research Center and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    J Cell Sci 118:4017-25. 2005
    ..Our data provide evidence for the existence of a previously unknown repressive complex, composed of an integral nuclear membrane protein and a histone modifier, at the nuclear periphery...
  5. ncbi HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics
    S B Martins
    Institute of Medical Biochemistry, University of Oslo, PO Box 1112 Blindern, Norway
    J Cell Sci 113:3703-13. 2000
    ..Cross-linking experiments, however, illustrate a tight association of HA95 with LBR and LAP2 only...
  6. doi Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes
    D W Craig
    Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Diabet Med 26:1090-8. 2009
    ....
  7. pmc Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA
    M Cai
    Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0510, USA
    EMBO J 20:4399-407. 2001
    The nuclear envelope proteins LAP2, emerin and MAN1 share a conserved approximately 40-residue 'LEM' motif. Loss of emerin causes Emery-Dreifuss muscular dystrophy...
  8. pmc Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics
    T Dechat
    nstitute of Biochemistry and Molecular Cell Biology, Biocenter and Institute of Tumor Biology Cancer Research, University of Vienna, A 1030 Vienna, Austria
    EMBO J 17:4887-902. 1998
    ..Some LAP2alpha may also associate with membranes prior to chromatin attachment. Altogether the data suggest a role of LAP2alpha in post-mitotic nuclear assembly and in the dynamic structural organization of the nucleus...
  9. pmc Three distinct human thymopoietins are derived from alternatively spliced mRNAs
    C A Harris
    Immunobiology Research Institute, Annandale, NJ 08801
    Proc Natl Acad Sci U S A 91:6283-7. 1994
    ..Proteins encoded by these mRNAs, which we have named TP alpha (75 kDa), TP beta (51 kDa), and TP gamma (39 kDa), contain identical N-terminal regions, including sequences ..
  10. ncbi Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins
    T Dechat
    Department of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Cell Sci 113:3473-84. 2000
    The nucleoskeletal protein lamina-associated polypeptide 2(&agr;) (LAP2*) contains a large, unique C terminus and differs significantly from its alternatively spliced, mostly membrane-integrated isoforms, such as LAP2beta...
  11. ncbi LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
    Thomas Dechat
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria
    J Cell Sci 117:6117-28. 2004
    ..We propose that LAP2alpha and a subfraction of BAF form defined complexes in chromatin core regions and may be involved in chromatin reorganization during early stages of nuclear assembly...
  12. ncbi The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain
    K Furukawa
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 273:4213-9. 1998
    b>LAP2 is an integral protein of the inner nuclear membrane which binds lamins and chromosomes and is suggested to have an important role in nuclear envelope organization...
  13. ncbi Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin
    K Furukawa
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    Eur J Biochem 251:729-33. 1998
    ..promote this localization, including the first (residues 1-296) and the second (residues 298-409) halves of the LAP2 N terminus. The second half is involved in LAP2 association with the nuclear lamina [Furukawa, K., Panté, N...
  14. pmc Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway
    Daniela Dorner
    Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 173:83-93. 2006
    Lamina-associated polypeptide (LAP) 2alpha is a nonmembrane-bound LAP2 isoform that forms complexes with nucleoplasmic A-type lamins...
  15. ncbi Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less)
    E Nili
    Pediatric Hemato Oncology Department, Division of Hematology, Chaim Sheba Medical Center, Tel Hashomer and the Sackler School of Medicine, Tel Aviv University, Israel
    J Cell Sci 114:3297-307. 2001
    ..Co-expression of both LAP2beta and mGCL with the E2F-DP complex resulted in a reduced transcriptional activity equal to that exerted by the pRb protein...
  16. ncbi Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy
    Matthew R G Taylor
    CU Cardiovascular Institute, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Hum Mutat 26:566-74. 2005
    Thymopoietin or TMPO (indicated by its alternative gene symbol, LAP2, in this work) has been proposed as a candidate disease gene for dilated cardiomyopathy (DCM), since a LAP2 product associates with nucleoplasmic lamins A/C, which are ..
  17. pmc Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein
    Ewa Markiewicz
    Department of Biological Sciences, The University of Durham, Durham DH1 3LE, United Kingdom
    Mol Biol Cell 13:4401-13. 2002
    ..Together, these data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha-lamin A/C complexes...
  18. ncbi Cell cycle dynamics of the nuclear envelope
    Roland Foisner
    Department of Medical Biochemistry, Section of Molecular Cell Biology, Vienna Biocenter, University of Vienna, Dr Bohrgasse 9, A 1030 Vienna, Austria
    ScientificWorldJournal 3:1-20. 2003
    ..Various chromatin-binding domains in lamina proteins, such as the LEM domain, present in all LAP2 isoforms and in emerin, as well as unique regions in lamina proteins and in specific LAP2 isoforms have been ..
  19. ncbi Lamins in disease: why do ubiquitously expressed nuclear envelope proteins give rise to tissue-specific disease phenotypes?
    C J Hutchison
    The Department of Biological Sciences, The University of Durham, South Road, Durham DH1 3LE, UK
    J Cell Sci 114:9-19. 2001
    ..Several integral membrane proteins including emerin, LBR, LAP1 and LAP2 bind to nuclear lamins in vitro and can influence lamin function and dynamics in vivo...
  20. ncbi Function and assembly of nuclear pore complex proteins
    K Bodoor
    Department of Cell Biology and Anatomy, University of Calgary, AB, Canada
    Biochem Cell Biol 77:321-9. 1999
    ..of NPC components (CAN/Nup214, Nup153, POM121, p62 and Tpr) relative to the integral inner nuclear membrane protein LAP2 and the NPC membrane glycoprotein gp210...
  21. doi LBR mutation and nuclear envelope defects in a patient affected with Reynolds syndrome
    Caroline Gaudy-Marqueste
    Service de Dermatologie, Hopital Ste Marguerite, Marseille, France
    J Med Genet 47:361-70. 2010
    ..search was undertaken for mutations in LMNA, encoding Lamins A/C, and ZMPSTE24, LBR, LMNB1, LMNB2, MAN1, SYNE1a and LAP2, encoding Lamins A/C molecular partners, in a Caucasian woman affected with Reynolds syndrome, a particular ..
  22. ncbi Distribution of emerin during the cell cycle
    M C Dabauvalle
    Department of Cell and Developmental Biology, Biocenter of the University of Wurzburg, Germany
    Eur J Cell Biol 78:749-56. 1999
    ..reassembly of the nuclear envelope at this mitotic stage emerin colocalizes with lamin A/C but not with lamin B and LAP2 proteins...
  23. doi Genetic and ultrastructural studies in dilated cardiomyopathy patients: a large deletion in the lamin A/C gene is associated with cardiomyocyte nuclear envelope disruption
    Pallavi Gupta
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, K1H 8M5, Canada
    Basic Res Cardiol 105:365-77. 2010
    ..of 25 unrelated DCM patient samples for (a) cardiomyocyte nuclear abnormalities and (b) mutations in LMNA and TMPO as they are two DCM-causing genes that encode proteins involved in maintaining nuclear envelope architecture...
  24. ncbi Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes
    James M Holaska
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 15:3459-72. 2006
    ..Misregulation of 11 genes, including four (CREBBP, NAP1L1, LAP2, RBL2) known to be misregulated in X-EDMD patients and emerin-null mice [Bakay, M., Wang, Z., Melcon, G...
  25. pmc The inner nuclear membrane protein LAP1 forms a native complex with B-type lamins and partitions with spindle-associated mitotic vesicles
    C Maison
    Department of Basic Sciences, The University of Crete School of Medicine, Heraklion, Greece
    EMBO J 16:4839-50. 1997
    ..The LAP1-lamin B complex is distinct from analogous complexes formed by the 'lamina-associated polypeptide-2' (LAP2), another inner nuclear membrane protein, and includes a protein kinase...
  26. pmc Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope
    K Furukawa
    Department of Biology, School of Science, Nagoya University, Japan
    EMBO J 14:1626-36. 1995
    Lamina-associated polypeptide 2 (LAP2) is an integral membrane protein of the inner nuclear membrane, which binds directly to both lamin B1 and chromosomes in a mitotic phosphorylation-regulated manner...
  27. pmc High-alcohol preferring mice are more impulsive than low-alcohol preferring mice as measured in the delay discounting task
    B G Oberlin
    Department of Psychology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 33:1294-303. 2009
    ..In this study, we address this question by testing alcohol-naïve mice from lines showing heritable differences in alcohol intake...
  28. ncbi Structural analysis of emerin, an inner nuclear membrane protein mutated in X-linked Emery-Dreifuss muscular dystrophy
    N Wolff
    Departement d Ingenierie et d Etudes des Proteines, CEA Saclay, Gif sur Yvette, France
    FEBS Lett 501:171-6. 2001
    ..in the two N-terminal domains of another inner nuclear membrane protein called lamina-associated protein 2 (LAP2)...
  29. ncbi Histone deacetylase inhibitors--a new tool to treat cancer
    Raz Somech
    Laboratory of Molecular Hemato Oncology, Sheba Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel
    Cancer Treat Rev 30:461-72. 2004
    ..laboratory is interested in the transcription repression mechanism induced by the nuclear envelope lamina associated polypeptide 2 (LAP2) family of proteins through chromatin modification...
  30. pmc Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells
    Brenda R Baldwin
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Mol Cell Biol 24:3682-91. 2004
    ..C/EBP beta is expressed as several distinct protein isoforms (LAP1, LAP2, and LIP) whose expression is regulated by alternative translational initiation at downstream AUG start sites...
  31. ncbi Trimethylphosphate: a 30-month chronic toxicity/carcinogenicity study in Wistar rats with administration in drinking water
    E M Bomhard
    Department of Toxicology, Carcinogenicity, and Genotoxicity, Bayer AG, Wuppertal, Germany
    Fundam Appl Toxicol 40:75-89. 1997
    Trimethylphosphate (TMPO) was administered to 50 male and 50 female Wistar rats through their drinking water at doses of 0, 1, 10, or 100 mg/kg body weight up to 30 months...
  32. ncbi Acoustic startle at baseline and during acute alcohol withdrawal in replicate mouse lines selectively bred for high or low alcohol preference
    Julia A Chester
    Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907 2081, USA
    Alcohol Clin Exp Res 31:1633-44. 2007
    ..differences in alcohol preference in 2 mouse lines selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) alcohol preference...
  33. ncbi Genomic structure and expression of parathyroid hormone-related protein gene (PTHrP) in a teleost, Fugu rubripes
    D M Power
    Centro de Ciências de MAR CCMAR, Universidade do Algarve, Campus de Gambelas, Faro, Portugal
    Gene 250:67-76. 2000
    ..Sequence scanning of overlapping cosmids has identified three additional genes, TMPO, LDHB and KCNA1, which map to human chromosome 12, with the latter two mapping to 12p12-11.2...
  34. ncbi The localization of LAP2 beta during pronuclear formation in bovine oocytes after fertilization or activation
    Mamiko Isaji
    Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University, Kobe 657 8501, Japan
    Zygote 14:157-67. 2006
    ..The results also indicate that CH treatment inhibits LAP2beta assembly around oCh but not histone H3 dephosphorylation...
  35. pmc RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs
    Gabriel Rinaldi
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Mol Biochem Parasitol 167:118-26. 2009
    ..japonicum. The similarities in sequence and exon/intron structure of the two genes, LAP1 and LAP2, suggest that they arose by gene duplication and that this occurred before separation of the mansoni and japonicum ..
  36. ncbi Drugs affecting prelamin A processing: effects on heterochromatin organization
    Elisabetta Mattioli
    IGM CNR, Unit of Bologna, c o IOR, Via di Barbiano 1 10 I 40136 Bologna, Italy
    Exp Cell Res 314:453-62. 2008
    ..At the biochemical level, heterochromatin-associated proteins and LAP2 alpha were clustered at the nuclear interior following FTI-277 treatment, while they were unevenly distributed or ..
  37. ncbi Direct interaction between emerin and lamin A
    L Clements
    MRIC Biochemistry Group, N E Wales Institute, Wrexham, LL11 2AW, United Kingdom
    Biochem Biophys Res Commun 267:709-14. 2000
    ..An emerin-lamin A interaction system may be related in function to the LAP2-lamin B system at the inner nuclear rim.
  38. ncbi Identification of phosphorylation sites in native lamina-associated polypeptide 2 beta
    M Dreger
    AG Neurochemie, Institut fur Biochemie, Freie Universitat Berlin, Germany
    Biochemistry 38:9426-34. 1999
    ..Additionally, we identified for the first time at the protein level the LAP 2 splice variant LAP 2 epsilon in nuclear envelopes...
  39. ncbi Domain-specific disassembly and reassembly of nuclear membranes during mitosis
    B Buendia
    Departement de Biologie Cellulaire, Institut Jacques Monod, CNRS, Paris, France
    Exp Cell Res 230:133-44. 1997
    ..In these studies, protein LAP2/thymopoietin beta, another marker of the inner nuclear membrane, was segregating as lamin B receptor, suggesting ..
  40. pmc CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases
    Cynthia A Zahnow
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Bunting Blaustein Cancer Research Building, 1650 Orleans St, Baltimore, MD 21231 1000, USA
    Expert Rev Mol Med 11:e12. 2009
    ..Encoded by an intronless gene, C/EBPbeta is expressed as several distinct protein isoforms (LAP1, LAP2, LIP) whose expression is regulated by the differential use of several in-frame translation start sites...
  41. ncbi The lamina-associated polypeptide 2 (LAP2) isoforms beta, gamma and omega of zebrafish: developmental expression and behavior during the cell cycle
    Vera K Schoft
    Division of Electron Microscopy, Biocenter of the University of Wü rzburg, Am Hubland, Germany
    J Cell Sci 116:2505-17. 2003
    ..The maternally synthesized omega is the largest isoform and the only LAP2 present in the rapidly dividing embryonic cells up to the gastrula stage...
  42. ncbi Molecular cloning of soluble aminopeptidases from Saccharomyces cerevisiae. Sequence analysis of aminopeptidase yscII, a putative zinc-metallopeptidase
    N García-Alvarez
    Departamento de Biologia Funcional, Facultad de Medicina, Universidad de Oviedo, Spain
    Eur J Biochem 202:993-1002. 1991
    Plasmids capable of complementing lap1, lap2 and lap3 mutations [R.J. Trumbly and G. Bradley (1983) J. Bacteriol...
  43. doi CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcinoma cells
    David A Armstrong
    Research Service, Department of Veterans Affairs, White River Junction, VT 05009, USA
    Mol Cancer Res 7:1517-24. 2009
    ..DNA affinity chromatography studies showed that the LAP1, LAP2, and LIP isoforms of CEBPB bind to the IL-1beta-responsive CEBPB site in the MMP-1 promoter...
  44. ncbi Variability and genetic differentiation among Anopheles (Ano.) intermedius Chagas, 1908 and Anopheles (Ano.) mattogrossensis Lutz & Neiva, 1911 (Diptera: Culicidae) from the Brazilian Amazon
    Joselita Maria Mendes dos Santos
    Coordenação de Pesquisas em Ciências da Saúde, Instituto Nacional de Pesquisas da Amazonia, Manaus, AM 69011 970, Brasil
    Mem Inst Oswaldo Cruz 100:531-7. 2005
    ..021). Most analyzed loci showed genotypic frequencies according to Hardy-Weinberg equilibrium, except for LAP1 and LAP2 in An. intermedius, and EST1 and PGM loci in An. mattogrossensis. The genetic distance between these species (D = 0...
  45. pmc Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans
    Ayelet Margalit
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    J Cell Biol 178:661-73. 2007
    ..to autointegration factor (BAF) binds double-stranded DNA, selected histones, transcription regulators, lamins, and LAP2-emerin-MAN1 (LEM) domain proteins...
  46. ncbi Spin labeled antioxidants protect bacteria against the toxicity of alkylating antitumor drug CCNU
    Vesselina Gadjeva
    Department of Chemistry and Biochemistry, Medical Faculty, Thracian University, 11 Armeiska Str, 6000 Stara Zagora, Bulgaria
    Toxicol Lett 144:289-94. 2003
    ..of oxygen radical-scavenging substances [Vitamin E, stable nitroxyl radical 2,2,6,6-tetramethylpiperidine-N-oxyl (TMPO), and spin labeled (nitroxyl free radical moiety containing) analogues of CCNU] and compared with that of the ..
  47. ncbi TP5 triggers signal transduction involving mitogen activated protein kinases in monocytes
    S Gonser
    Department of Pharmacy, ETH Zurich, Switzerland
    J Recept Signal Transduct Res 19:155-66. 1999
    ..Recently however it was shown, that TP represents the N-terminal 49 aa of the human thymopoietin (TMPO) isoforms TMPO alpha, beta and gamma, which are localized in the nucleus...
  48. ncbi Design of a new dental adhesive--effect of a water-soluble sodium acylphosphine oxide with crown ether on adhesion to dental hard tissues
    Kunio Ikemura
    Department of Research and Development, Shofu Inc, 11 Kamitakamatsu cho, Fukuine, Higashiyama ku, Kyoto 605 0983, Japan
    Dent Mater J 28:267-76. 2009
    ..Sodium 2,4,6-trimethylbenzoyl-phenylphosphine oxide (TMPO-Na = APO-Na) was synthesized in 67.1% yield and identified by 1H NMR...
  49. ncbi Ubiquitous expression of a cloned murine thymopoietin cDNA
    L Theodor
    Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Acta Haematol 97:153-63. 1997
    ..that one of the TP isoforms designated TP beta is a homologous protein to the lamina-associated polypeptide 2 (LAP2), which is thought to play an important role in the regulation of nuclear architecture by binding lamin B1 and ..
  50. pmc Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase
    Sujiet Puthenveetil
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 131:16430-8. 2009
    ..Four rounds of evolution followed by additional rational mutagenesis produced a "LAP2" sequence with a k(cat)/K(m) of 0...
  51. doi Proteomic profiling of endothelial cells in human lung cancer
    Hye Jeong Park
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, Korea
    J Proteome Res 7:1138-50. 2008
    ..In an additional experiment in which 16 cancer samples were analyzed by immunohistochemistry, PRDX4, thymopoietin (TMPO), and COPG were confirmed to be abundantly expressed in lung cancer-derived ECs and in cancerous lung cells...
  52. doi Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination
    Ivana Gotic
    Department of Medical Biochemistry, Max F Perutz Laboratories, Center of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
    Stem Cells 28:480-8. 2010
    Lamina-associated polypeptide 2 alpha (LAP2 alpha) is a nucleoplasmic protein implicated in cell cycle regulation through its interaction with A-type lamins and the retinoblastoma protein...
  53. ncbi Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Oncol 95:307-13. 2004
    ..The objective of this study was to determine whether P-LAP expression affects the chemosensitivity in endometrial carcinoma patients...
  54. ncbi Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines
    Paula J Bice
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Behav Genet 36:248-60. 2006
    The High- and Low-Alcohol Preferring (HAP1/LAP1 and HAP2/LAP2) mouse lines were developed by selective breeding for differences in alcohol preference...
  55. pmc Roles of LAP2 proteins in nuclear assembly and DNA replication: truncated LAP2beta proteins alter lamina assembly, envelope formation, nuclear size, and DNA replication efficiency in Xenopus laevis extracts
    T M Gant
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 144:1083-96. 1999
    Humans express three major splicing isoforms of LAP2, a lamin- and chromatin-binding nuclear protein. LAP2beta and gamma are integral membrane proteins, whereas alpha is intranuclear...
  56. ncbi Prolonged biologically active transgene expression driven by HSV LAP2 in brain in vivo
    Veljko Puskovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Mol Ther 10:67-75. 2004
    ..latency-associated transcripts (LATs) in the absence of viral lytic functions, and the latency-associated promoter (LAP2) has been identified as a moveable element responsible for the expression of LATs from latent HSV genomes...
  57. doi Selection for high alcohol preference drinking in mice results in heightened sensitivity and rapid development of acute functional tolerance to alcohol's ataxic effects
    B M Fritz
    Indiana Alcohol Research Center and Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Genes Brain Behav 12:78-86. 2013
    ..preference and AFT in second and third replicate lines of mice selectively bred for high (HAP2 and HAP3) and low (LAP2 and LAP3) alcohol preference drinking...
  58. doi Molecular identification and characterization of leucine aminopeptidase 2, an excretory-secretory product of Clonorchis sinensis
    Chuanhuan Deng
    Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, China
    Mol Biol Rep 39:9817-26. 2012
    ..In the present study, leucine aminopeptidase 2 (LAP2) gene of Clonorchis sinensis (C. sinensis) was isolated and identified from an adult cDNA library of C. sinensis...
  59. ncbi Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization
    Naoki Yokota
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The University of Toronto, Toronto, Ontario, Canada
    Oncogene 23:3444-53. 2004
    ..Genes found to be upregulated in the murine MB library included cyclin D2 (Ccnd2), thymopoietin (Tmpo), Musashi-1 (Msh1), protein phosphatase 2A inhibitor-2 (I-2pp2a), and Unc5h4(D)...
  60. ncbi [Induction of nuclear envelope formation around individual chromosomes under impact of hypotonic shock]
    S Iu Kurchashova
    Department of Electron Microscopy, Research Institute of Physico Chemical Biology after A N Belozersky, Moscow State University
    Tsitologiia 45:298-307. 2003
    ..we have studied the distribution of some proteins participating in the nuclear envelope assembly (lamins A/C, B and LAP2 alpha) in mitotic cells and after hypotonic treatment with 15% Hank's solution...
  61. pmc Prolonged regulatable expression of EPO from an HSV vector using the LAP2 promoter element
    Z Wu
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI 48109, USA
    Gene Ther 19:1107-13. 2012
    ..Taken together, these results suggest such a vector is well suited for clinical trial for the treatment of chronic or subacutely developing neuropathy...
  62. pmc Sexual function of patients with endometrial cancer enrolled in the Gynecologic Oncology Group LAP2 Study
    Jeanne Carter
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Int J Gynecol Cancer 22:1624-33. 2012
    ..to sexual function items contained within the quality of life (QOL) survey of the Gynecologic Oncology Group LAP2 study, to investigate associations between sexual function and other factors (such as relationship quality and body ..
  63. ncbi Inner nuclear membrane proteins: functions and targeting
    L Holmer
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell Mol Life Sci 58:1741-7. 2001
    ..that reside in the inner nuclear membrane, including lamin B receptor (LBR), lamina-associated polypeptide (LAP) 1, LAP2, emerin, MAN1 and nurim. Most of these proteins interact with lamins and chromatin...
  64. ncbi Analysis of regulatory functions for the region located upstream from the latency-associated transcript (LAT) promoter of pseudorabies virus in cultured cells
    Satoshi Taharaguchi
    Laboratory of Animal Experiment for Disease Model, Institute for Genetic, Medicine, Hokkaido University, 060 0815, Sapporo, Japan
    Vet Microbiol 85:197-208. 2002
    ..Although two different sequences, LAP1 and LAP2, are thought to be involved in LAT gene expression, the function of the upstream region of the LAT promoter (LAP1 ..
  65. pmc Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophy
    Hong Ki Song
    School of Life Sciences and Systems Biology Research Center, Gwangju Institute of Science and Technology GIST, Gwangju, Republic of Korea
    PLoS ONE 7:e35552. 2012
    ..The splicing variants of 8 genes (i.e., Fhl1, Rcan1, Ndrg2, Synpo, Ttll1, Cxxc5, Egfl7, and Tmpo) were experimentally confirmed...
  66. pmc Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein
    Belinda S Pinto
    Molecular and Cellular Biology Program, University of Iowa, College of Medicine, Iowa City, Iowa 52242, USA
    Genetics 180:133-45. 2008
    ..One family of lamina proteins is defined by an approximately 40-aa LAP2, Emerin, and MAN1 (LEM) domain (LEM-D) that binds the nonspecific DNA-binding protein, barrier-to-autointegration ..
  67. pmc Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group Study LAP2
    Joan L Walker
    University of Oklahoma, Oklahoma City, OK 73190, USA
    J Clin Oncol 27:5331-6. 2009
    ..The objective was to compare laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer...
  68. pmc Lamin-binding fragment of LAP2 inhibits increase in nuclear volume during the cell cycle and progression into S phase
    L Yang
    Departments of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 139:1077-87. 1997
    Lamina-associated polypeptide 2 (LAP2) is an integral membrane protein of the inner nuclear membrane that binds to both lamin B and chromatin and has a putative role in nuclear envelope (NE) organization...
  69. ncbi Nuclear assembly
    T M Gant
    Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Cell Dev Biol 13:669-95. 1997
    ..There are four identified proteins localized to the inner nuclear membrane: the lamina-associated proteins LAP1 and LAP2, emerin, and the lamin B receptor (LBR)...
  70. ncbi Molecular characterization and developmentally regulated expression of Xenopus lamina-associated polypeptide 2 (XLAP2)
    C Lang
    Division of Electron Microscopy, and Department of Cell and Developmental Biology, Biocenter of the University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    J Cell Sci 112:749-59. 1999
    ..By cDNA cloning we have characterized XLAP2, a Xenopus homologue of the mammalian LAP2beta. Using LAP2-specific antibodies, the Mr 68,000 XLAP2 was found to be the only member of the LAP2/TP family expressed in somatic ..
  71. ncbi Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis
    B Buendia
    Département de Biologie Supramoléculaire et Cellulaire, Institut Jacques Monod, CNRS, Universite Paris 7, Tour 43, 75251 Paris Cedex 05, France
    J Cell Sci 112:1743-53. 1999
    ..of the three domains of the nuclear envelope, namely lamin B (LB) for the lamina, transmembrane proteins LBR and LAP2 for the inner nuclear membrane, and nucleoporins p62, Nup153 and gp210 for the nuclear pore complexes (NPCs), we ..
  72. doi mRNA retrotransposition coupled with 5' inversion as a possible source of new genes
    Kenji K Kojima
    Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
    Mol Biol Evol 26:1405-20. 2009
    ..We identified several potential 5'-inverted retrogenes, including those of thymopoietin beta (TMPO) and eukaryotic translation initiation factor 3 subunit 5 (EIF3F)...
  73. ncbi Measurement and characterization of singlet oxygen production in copper ion-catalyzed aerobic oxidation of ascorbic acid
    Bo Song
    Department of Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, PR China
    Talanta 72:231-6. 2007
    ..of (1)O(2) with 2,2,6,6-tetramethyl-4-piperidinol (TMP-OH), the corresponding free radical of TMP-OH oxide (TMPO) was detected by electron spin resonance (ESR) spectroscopy...
  74. pmc C/EBPbeta-mediated transcriptional regulation of bcl-xl gene expression in human breast epithelial cells in response to cigarette smoke condensate
    S K Connors
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Oncogene 28:921-32. 2009
    ..Additionally, overexpression of C/EBPbeta-LAP2 stimulated pBcl-xLP activity and Bcl-xL protein levels, which mimicked the conditions of CSC treatment...
  75. pmc Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes
    Casey D Wright
    Cardiovascular Research Center, Sanford Research USD, Sioux Falls, SD 57105, USA
    Circ Res 103:992-1000. 2008
    ..Similar to endogenous alpha1-ARs and alpha1A- and alpha1B-GFP colocalized with LAP2 at the nuclear membrane. alpha1-AR nuclear localization was confirmed in vivo using alpha1-AR-GFP transgenic mice...
  76. pmc The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression
    Stefanie E Grund
    Biochemie Zentrum der Universitat Heidelberg, D 69120 Heidelberg, Germany
    J Cell Biol 182:897-910. 2008
    Inner nuclear membrane proteins containing a LEM (LAP2, emerin, and MAN1) domain participate in different processes, including chromatin organization, gene expression, and nuclear envelope biogenesis...
  77. ncbi Isolation and characterization of the complete mouse emerin gene
    K Small
    Howard Hughes Medical Institute and Department of Biochemistry, Emory University School of Medicine, Room 4035 Rollins Research Center, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Mamm Genome 8:337-41. 1997
    ..gene has recently been identified and found to encode a serine-rich protein similar to lamina-associated protein 2 (LAP2), although the disease mechanism remains obscure...
  78. pmc Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice
    Ivana Gotic
    Max F Perutz Laboratories, Medical University of Vienna, Dr Bohr Gasse 9 3, A 1030 Vienna, Austria
    Circ Res 106:346-53. 2010
    ..Because mutations in lamins and LAP2alpha lead to cardiac disorders in humans, we hypothesized that these factors may play important roles in heart development and adult tissue homeostasis...
  79. doi Evolvement of LEM proteins as chromatin tethers at the nuclear periphery
    Andreas Brachner
    Max F Perutz Laboratories, Medical University of Vienna, Dr Bohr Gasse 9, Vienna, Austria
    Biochem Soc Trans 39:1735-41. 2011
    ..The inner nuclear membrane contains over 60 transmembrane proteins. LEM [LAP2 (lamina-associated polypeptide 2)/emerin/MAN1] domain-containing proteins of the inner nuclear membrane are ..
  80. ncbi Immunoassay for bovine serum thymopoietin: discrimination from splenin by monoclonal antibodies
    A Fuccello
    Arch Biochem Biophys 228:292-8. 1984
    ..Similar approaches are being pursued to develop an immunoassay for thymopoietin in human serum...
  81. ncbi High iFGF23 level despite hypophosphatemia is one of the clinical indicators to make diagnosis of XLH
    Junko Miyamoto Igaki
    Division of Endocrinology and Metabolism, Tokyo Metropolitan Children s Hospital, Japan
    Endocr J 58:647-55. 2011
    ..bone deformity, The ratio of maximum rate of renal tubular reabsorption of phosphate to glomerular filtration rate (TmPO(4)/GFR), inorganic phosphate (IP), Alkaline Phosphatase (ALP), therapeutic dose) were investigated...
  82. ncbi [Karyoskeletal and nuclear envelope proteins in cell cycle progression--known proteins in new functions]
    Magda Dubińska-Magiera
    Pracownia Białek Jadrowych, Wydział Biotechnologii, Uniwersytet Wrocławski, Wrocław
    Postepy Biochem 56:362-72. 2010
    ..Nuclear envelope, which is composed of integral membrane proteins of the INM (LAP1, LAP2, emerin, MAN1, LBR), has many functions including: connection of nucleoskeleton with cytoskeleton, nuclear lamina ..
  83. doi CCAAT-enhancer-binding protein beta activation of MMP-1 gene expression in SW1353 cells: independent roles of extracellular signal-regulated and p90/ribosomal S6 kinases
    Brenda L Petrella
    Research Service, Department of Veterans Affairs, White River Junction, Vermont 05009, USA
    J Cell Physiol 226:3349-54. 2011
    ..Exogenous expression of the CEBPB isoforms LAP1 or LAP2 was sufficient to induce MMP-1 mRNA levels comparable to IL-1B-induced expression, while the truncated LIP isoform ..
  84. doi Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples
    Sophie Lachapelle
    Centre de Recherche en Cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Québec City, Québec, G1R 2J6, Canada
    J Proteome Res 10:1216-27. 2011
    ..Among the top 15 hits, we find the new interactors TMPO, HNRNPU, RPS3, RALY, RPS9 DDX21, and HNRNPM...
  85. ncbi New insights into Keggin-type 12-tungstophosphoric acid from 31P MAS NMR analysis of absorbed trimethylphosphine oxide and DFT calculations
    Shing Jong Huang
    Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan
    Chem Asian J 6:137-48. 2011
    ..HPW) have been studied by solid-state (31)P magic-angle spinning NMR of absorbed trimethylphosphine oxide (TMPO) in conjunction with DFT calculations...
  86. doi Ethanol consumption in mice: relationships with circadian period and entrainment
    Jennifer L Trujillo
    Department of Psychology, University of California, San Diego, CA 92093 0109, USA
    Alcohol 45:147-59. 2011
    ..Male inbred C57Bl/6J mice and replicate 2 male and female HAP2 and LAP2 mice were entrained to light:dark cycles of 26 or 22 h or remained in a standard 24 h cycle...
  87. pmc FGF-23 Levels before and after Renal Transplantation
    Domniki Economidou
    University Department of Nephrology, Hippokration General Hospital, 54642 Thessaloniki, Greece
    J Transplant 2009:379082. 2009
    ..Renal threshold phosphate concentration (TmPO(4)/GFR) was also calculated at 3, 6, and 12 months posttransplantation...
  88. ncbi Characterization of the chromatin binding activity of lamina-associated polypeptide (LAP) 2
    K Furukawa
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    Biochem Biophys Res Commun 238:240-6. 1997
    Previous studies have shown that the first and the second halves of the LAP2 N-terminal nucleoplasmic domain function independently in targeting LAP2 to the nuclear envelope, and that the second half is involved in association with the ..
  89. doi LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression
    Sigal Shaklai
    Sheba Cancer Research Center and the Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, 52621, Israel
    Eur J Cell Biol 87:267-78. 2008
    ..We now show that LAP2zeta, the smallest LAP2 family member, is also involved in regulation of transcription...
  90. ncbi The nuclear lamina: molecular organization and interaction with chromatin
    M Goldberg
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    Crit Rev Eukaryot Gene Expr 9:285-93. 1999
    ..These include interactions between nuclear lamins and core histones, Lamina Associated Polypeptide 2 (LAP2), and the Barrier to Autointegration Factor (BAF) and interactions between lamin B receptor (..
  91. ncbi MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin
    F Lin
    Departments of Medicine and of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 275:4840-7. 2000
    ..The LEM module is also present in two proteins of Caenorhabditis elegans. These results show that MAN1 is an integral protein of the inner nuclear membrane that shares the LEM module with other proteins of this subcellular localization...
  92. ncbi In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling
    Sandra B Martins
    Institute of Medical Biochemistry, University of Oslo, P O Box 1112 Blindern, 0317 Oslo, Norway
    Biochemistry 42:10456-61. 2003
    ..This suggests an additional level of regulation of a chromatin-nuclear envelope interaction in dividing cells...
  93. ncbi Renal function and tubular phosphate handling in long-term cyclosporine- and tacrolimus-based immunosuppression in kidney transplantation
    K Falkiewicz
    Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, ul Traugutta 57 59, 50 417 Wroclaw, Poland
    Transplant Proc 38:119-22. 2006
    ..phosphate reabsorption (TRP; mmol/L), and tubular maximum phosphate reabsorption per glomerular filtration rate (TmPO(4)/GFR; mmol/L)-were assessed at 1, 6, 12, 18, and 24 months (groups A and C) or 24, 30, 36, 42, and 48 months (..
  94. ncbi Nuclear envelope and chromatin compositional differences comparing undifferentiated and retinoic acid- and phorbol ester-treated HL-60 cells
    A L Olins
    Foundation for Blood Research, P O Box 190, 69 U S Route One, Scarborough, Maine 04070 0190, USA
    Exp Cell Res 268:115-27. 2001
    ..demonstrated that following RA treatment: lamins A/C and B1, and vimentin decreased to negligible amounts; LAP2 beta, lamin B2 and emerin remained essentially unchanged; lamin B receptor (LBR) increased markedly; histone ..
  95. ncbi Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF
    K K Lee
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    J Cell Sci 114:4567-73. 2001
    ..The demonstration that emerin binds directly to BAF, coupled to similar results for LAP2, provides proof in principle that all LEM-domain nuclear proteins can interact with BAF, with interesting ..
  96. ncbi Binding of barrier to autointegration factor (BAF) to histone H3 and selected linker histones including H1.1
    Rocio Montes De Oca
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 280:42252-62. 2005
    ..BAF binds directly to LEM domain nuclear proteins (e.g. LAP2, Emerin, and MAN1), lamin A, homeodomain transcription factors, and human immunodeficiency virus type 1-encoded ..
  97. ncbi Lamina-associated polypeptide 2 (LAP2) expression in fish and amphibians
    Eugenia M Del-Pino
    Departamento de Ciencias Biologicas, Pontificia Universidad Catolica del Ecuador, Quito
    Int J Dev Biol 46:227-34. 2002
    ..fish and 33 amphibian species were examined by SDS-PAGE followed by immunoblotting to determine the expression of LAP2 (lamina-associated polypeptide 2)...
  98. pmc Mouse germ cell-less as an essential component for nuclear integrity
    Tohru Kimura
    Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita Shi, Osaka 565 0871, Japan
    Mol Cell Biol 23:1304-15. 2003
    ..gene is expressed ubiquitously, and its gene product is localized to the nuclear envelope based on its binding to LAP2 beta (lamina-associated polypeptide 2 beta)...
  99. ncbi Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope
    Alejandra Tomas
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    J Biol Chem 278:20210-6. 2003
    ....
  100. ncbi Dynamic interaction between BAF and emerin revealed by FRAP, FLIP, and FRET analyses in living HeLa cells
    Takeshi Shimi
    CREST of JST, Kansai Advanced Research Center, CRL, Kobe 651 2492, Japan
    J Struct Biol 147:31-41. 2004
    ..BAF interacts with LEM-domain proteins including emerin, LAP2 beta, and MAN1 in the inner nuclear membrane...
  101. ncbi Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in HeLa cells
    Kim Bechert
    Max Planck Institute for Biophysical Chemistry, Department of Biochemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Exp Cell Res 286:75-86. 2003
    ..Lamins C, B1 and B2, Nup153, LAP2, and emerin were recruited into aggregates, resulting in a decrease of these proteins at the nuclear rim...

Research Grants37

  1. REGULATION OF NUCLEAR ENVELOPE ASSEMBLY AND DISASSEMBLY
    Katherine Wilson; Fiscal Year: 2007
    ..BAF binds a family of nuclear membrane proteins that includes LAP2[5 and emerin...
  2. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..alcohol drinking behavior in mouse lines that have been selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) alcohol preference...
  3. ORGANIZATION AND FUNCTION OF THE NUCLEAR LAMINA
    Larry Gerace; Fiscal Year: 1999
    ..analysis in mammalian cells of two lamin-binding integral membrane protein of the inner nuclear membrane, LAP1 and lAP2. These are good candidates for proteins involved in attachment and assembly of lamins at the inner nuclear membrane...
  4. Roles of BAF-Like in the nucleus
    Miriam Segura Totten; Fiscal Year: 2005
    ..To test this hypothesis, we will study the interactions of BAF-L with BAF, LAP2 and MLL3 in vitro and in vivo...
  5. Rodents with genetic differences in alcohol preference
    Lawrence Lumeng; Fiscal Year: 2007
    ..2) To produce and export to off-campus researchers selectively bred or inbred P/NP, HAD1/LAD1 and HAD2/LAD2 rats. And (3) to produce and export to external institutions selectively bred HAP1/LAP1 and HAP2/LAP2 mice.
  6. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA CHESTER; Fiscal Year: 2007
    ..alcohol drinking behavior in mouse lines that have been selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) alcohol preference...
  7. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
    ..Encoded by an intronless gene, C/EBPB is expressed as several distinct protein isoforms (LAP1, LAP2 and LIP) whose expression is tightly regulated by the differential use of a number of in-frame translation start ..
  8. Identification of Genes for Alcohol Preference in Noninbred Rats and Mice
    Paula Bice; Fiscal Year: 2009
    ..abstract_text> ..
  9. Measuring the Aversive Effects of Alcohol Withdrawal
    JULIA CHESTER; Fiscal Year: 2006
    ..Studies using this place conditioning technique are likely to provide important information that will lead to the development of novel behavioral and pharmacological treatments for alcoholism. ..
  10. Familial Dilated Cardiomyopathy:Genetic Characterization
    Matthew Taylor; Fiscal Year: 2006
    ..In addition, a diverse collection of consultants has been assembled to provide ongoing expertise that is sensitive to the needs of both the research and career development plans of the candidate. ..