Gene Symbol: TMPO
Description: thymopoietin
Alias: CMD1T, LAP2, LEMD4, PRO0868, thymopoietin, LEM domain containing 4, TP alpha, TP beta/gamma, lamina-associated polypeptide 2, thymopoietin beta, thymopoietin-related peptide isoform alpha, thymopoietin-related peptide isoforms beta/gamma
Species: human
Products:     TMPO

Top Publications

  1. Furukawa K. LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction. J Cell Sci. 1999;112 ( Pt 15):2485-92 pubmed
    ..The chromatin- and lamin-binding activity of LAP2 suggests that LAP2 plays an important role in targeting mitotic vesicles to chromosomes and reorganizing the ..
  2. Dechat T, Korbei B, Vaughan O, Vlcek S, Hutchison C, Foisner R. Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins. J Cell Sci. 2000;113 Pt 19:3473-84 pubmed
    The nucleoskeletal protein lamina-associated polypeptide 2(&agr;) (LAP2*) contains a large, unique C terminus and differs significantly from its alternatively spliced, mostly membrane-integrated isoforms, such as LAP2beta...
  3. Markiewicz E, Dechat T, Foisner R, Quinlan R, Hutchison C. Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein. Mol Biol Cell. 2002;13:4401-13 pubmed
    ..Together, these data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha-lamin A/C complexes. ..
  4. Dechat T, Gajewski A, Korbei B, Gerlich D, Daigle N, Haraguchi T, et al. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. J Cell Sci. 2004;117:6117-28 pubmed
    ..We propose that LAP2alpha and a subfraction of BAF form defined complexes in chromatin core regions and may be involved in chromatin reorganization during early stages of nuclear assembly. ..
  5. Furukawa K, Fritze C, Gerace L. The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain. J Biol Chem. 1998;273:4213-9 pubmed
    b>LAP2 is an integral protein of the inner nuclear membrane which binds lamins and chromosomes and is suggested to have an important role in nuclear envelope organization...
  6. Cai M, Huang Y, Ghirlando R, Wilson K, Craigie R, Clore G. Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA. EMBO J. 2001;20:4399-407 pubmed
    The nuclear envelope proteins LAP2, emerin and MAN1 share a conserved approximately 40-residue 'LEM' motif. Loss of emerin causes Emery-Dreifuss muscular dystrophy...
  7. Dechat T, Gotzmann J, Stockinger A, Harris C, Talle M, Siekierka J, et al. Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics. EMBO J. 1998;17:4887-902 pubmed
    ..Some LAP2alpha may also associate with membranes prior to chromatin attachment. Altogether the data suggest a role of LAP2alpha in post-mitotic nuclear assembly and in the dynamic structural organization of the nucleus. ..
  8. Berger R, Theodor L, Shoham J, Gokkel E, Brok Simoni F, Avraham K, et al. The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products. Genome Res. 1996;6:361-70 pubmed
    ..are a group of ubiquitously expressed nuclear proteins, with sequence homology to lamina-associated polypeptide 2 (LAP2)...
  9. Somech R, Shaklai S, Geller O, Amariglio N, Simon A, Rechavi G, et al. The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation. J Cell Sci. 2005;118:4017-25 pubmed
    ..Our data provide evidence for the existence of a previously unknown repressive complex, composed of an integral nuclear membrane protein and a histone modifier, at the nuclear periphery. ..

More Information


  1. Harris C, Andryuk P, Cline S, Chan H, Natarajan A, Siekierka J, et al. Three distinct human thymopoietins are derived from alternatively spliced mRNAs. Proc Natl Acad Sci U S A. 1994;91:6283-7 pubmed
    b>Thymopoietin (TP) was originally isolated as a 5-kDa 49-aa protein from bovine thymus in studies of the effects of thymic extracts on neuromuscular transmission and was subsequently observed to affect T-cell differentiation and function...
  2. Taylor M, Slavov D, Gajewski A, Vlcek S, Ku L, Fain P, et al. Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. Hum Mutat. 2005;26:566-74 pubmed
    b>Thymopoietin or TMPO (indicated by its alternative gene symbol, LAP2, in this work) has been proposed as a candidate disease gene for dilated cardiomyopathy (DCM), since a LAP2 product associates with nucleoplasmic lamins A/C, which are ..
  3. Furukawa K, Kondo T. Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin. Eur J Biochem. 1998;251:729-33 pubmed
    ..promote this localization, including the first (residues 1-296) and the second (residues 298-409) halves of the LAP2 N terminus. The second half is involved in LAP2 association with the nuclear lamina [Furukawa, K., Panté, N...
  4. Martins S, Eide T, Steen R, Jahnsen T, Skålhegg B S, Collas P. HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics. J Cell Sci. 2000;113 Pt 21:3703-13 pubmed
    ..Cross-linking experiments, however, illustrate a tight association of HA95 with LBR and LAP2 only...
  5. Foisner R, Gerace L. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. Cell. 1993;73:1267-79 pubmed
    ..Together, these data suggest that LAP 2 may have a key role in initial events of nuclear envelope reassembly, and that both LAP 2 and LAP 1 may be involved in attaching lamins to the nuclear envelope. ..
  6. Nili E, Cojocaru G, Kalma Y, Ginsberg D, Copeland N, Gilbert D, et al. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci. 2001;114:3297-307 pubmed
    ..Co-expression of both LAP2beta and mGCL with the E2F-DP complex resulted in a reduced transcriptional activity equal to that exerted by the pRb protein. ..
  7. Dorner D, Vlcek S, Foeger N, Gajewski A, Makolm C, Gotzmann J, et al. Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. J Cell Biol. 2006;173:83-93 pubmed
    Lamina-associated polypeptide (LAP) 2alpha is a nonmembrane-bound LAP2 isoform that forms complexes with nucleoplasmic A-type lamins...
  8. Carter J, Huang H, Chase D, Walker J, Cella D, Wenzel L. Sexual function of patients with endometrial cancer enrolled in the Gynecologic Oncology Group LAP2 Study. Int J Gynecol Cancer. 2012;22:1624-33 pubmed publisher sexual function items contained within the quality of life (QOL) survey of the Gynecologic Oncology Group LAP2 study, to investigate associations between sexual function and other factors (such as relationship quality and body ..
  9. Dubińska Magiera M, Kozioł K, Machowska M, Piekarowicz K, Filipczak D, Rzepecki R. Emerin Is Required for Proper Nucleus Reassembly after Mitosis: Implications for New Pathogenetic Mechanisms for Laminopathies Detected in EDMD1 Patients. Cells. 2019;8: pubmed publisher
    Emerin is an essential LEM (LAP2, Emerin, MAN1) domain protein in metazoans and an integral membrane protein associated with inner and outer nuclear membranes...
  10. Li J, Shan F, Xiong G, Wang J, Wang W, Xu X, et al. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells. Biochem Biophys Res Commun. 2014;446:267-71 pubmed publisher
    ..Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through ..
  11. Huang H, Yue Y, Chen Z, Chen Y, Wu S, Liao J, et al. Electrochemical sensor based on a nanocomposite prepared from TmPO4 and graphene oxide for simultaneous voltammetric detection of ascorbic acid, dopamine and uric acid. Mikrochim Acta. 2019;186:189 pubmed publisher
    A nanocomposite is described that consists of TmPO4 and graphene oxide (GO) and is used to modify a glassy carbon electrode (GCE) to obtain a sensor for simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric ..
  12. Li L, Peng M, Xue W, Fan Z, Wang T, Lian J, et al. Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma. J Transl Med. 2018;16:372 pubmed publisher
    ..In addition, 14 target genes (ARHGAP11A, ASPM, HELLS, PRC1, TMPO, ARHGAP30, CD52, IL16, IRF8, P2RY13, PRKCB, PTPRC, SASH3 and TRAF3IP3) were found to be associated with survival in ..
  13. Flanagan K, Alspach E, Pazolli E, Parajuli S, Ren Q, Arthur L, et al. c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors. Oncotarget. 2018;9:21-36 pubmed publisher
    ..In response to senescence, the full-length activating C/EBPβ isoform LAP2 increases binding to the OPN, IL-6, and IL-8 promoters...
  14. Coppola A, Montalcini T, Gallotti P, Luzi L, Pujia A, Giustina A, et al. Transmucosal oxygen tension of the clitoris: a new parameter for future investigations of the sexual, metabolic, and cardiovascular health of women. Endocrine. 2019;63:177-181 pubmed publisher
    ..The aim of this study was to evaluate whether transmucosal oxygen tension (TmPO2) can be measured at the mucosal surface of clitoris and whether the measurements are reliable...
  15. Mirza A, McKellar S, Urman N, Brown A, Hollmig T, Aasi S, et al. LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription. Cell. 2019;176:198-212.e15 pubmed publisher
    ..Here we identify a lamina-associated polypeptide 2 (LAP2) isoform-dependent nuclear chaperoning system that regulates GLI1 movement between the nuclear lamina and ..
  16. Wang J, Kondo T, Yamane T, Nakazawa T, Oish N, Mochizuki K, et al. Expression of nuclear membrane proteins in normal, hyperplastic, and neoplastic thyroid epithelial cells. Virchows Arch. 2015;467:427-36 pubmed publisher
    Emerin, lamin A/C, lamin B, and lamin-associated polypeptide 2 (LAP2) are nuclear membrane proteins that play an important role in maintaining nuclear structure and coordinating cell activity...
  17. Zaragoza M, Fung L, Jensen E, Oh F, Cung K, McCarthy L, et al. Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. PLoS ONE. 2016;11:e0155421 pubmed publisher
    ..357-2A>G, a novel heterozygous splice-site mutation as the primary mutation with rare or novel variants in HCN4, MYBPC3, PKP4, TMPO, TTN, DMPK and KCNJ10 as potential modifiers and a mechanism consistent with haploinsufficiency.
  18. Barrales R, Forn M, Georgescu P, Sarkadi Z, Braun S. Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2. Genes Dev. 2016;30:133-48 pubmed publisher
    ..Chromatin association and tethering of centromeres to the periphery are mediated by the N-terminal LEM (LAP2-Emerin-MAN1) domain of Lem2, whereas telomere anchoring and heterochromatin silencing require exclusively its ..
  19. Di Luca A, Henry M, Meleady P, O CONNOR R. Label-free LC-MS analysis of HER2+ breast cancer cell line response to HER2 inhibitor treatment. Daru. 2015;23:40 pubmed publisher
    ..This proteomic study highlights several proteins that are closely associated with early HER2-inhibitor response and will provide a valuable resource for further investigation of ways to improve efficacy of breast-cancer treatment. ..
  20. Cipriani C, Pepe J, Clementelli C, Manai R, Colangelo L, Fassino V, et al. Effect of a single intravenous zoledronic acid administration on biomarkers of acute kidney injury (AKI) in patients with osteoporosis: a pilot study. Br J Clin Pharmacol. 2017;83:2266-2273 pubmed publisher
    ..FGF23 (pFGF23), serum (s) Klotho, calcium excretion (CaEx) and renal threshold phosphate concentration/GFR (TmPO4 /GFR) were assessed at baseline, 24 h and Day 30 after administration...
  21. Bergqvist C, Jafferali M, Gudise S, Márkus R, Hallberg E. An inner nuclear membrane protein induces rapid differentiation of human induced pluripotent stem cells. Stem Cell Res. 2017;23:33-38 pubmed publisher
    ..Membrane Protein 1) interacts with Lamin A/C and the INM protein Emerin, which has a chromatin binding LEM (Lap2-Emerin-Man1)-domain. In this paper we investigate if Samp1 can play a role in the differentiation of iPSCs...
  22. Xia P, Zhang R, Ge G. C/EBPβ Mediates TNF-α-Induced Cancer Cell Migration by Inducing MMP Expression Dependent on p38 MAPK. J Cell Biochem. 2015;116:2766-77 pubmed publisher
    ..C/EBPβ is translated into transcriptional activator LAP1 and LAP2 and transcriptional repressor LIP utilizing alternative in-frame translation start sites...
  23. Barton L, Soshnev A, Geyer P. Networking in the nucleus: a spotlight on LEM-domain proteins. Curr Opin Cell Biol. 2015;34:1-8 pubmed publisher
    ..This review highlights a prominent family of nuclear lamina proteins that carries the LAP2-emerin-MAN1-domain (LEM-D)...
  24. Chester J, Weera M. Genetic correlation between alcohol preference and conditioned fear: Exploring a functional relationship. Alcohol. 2017;58:127-137 pubmed publisher
    ..on alcohol consumption and the effects of alcohol consumption on the expression of FPS in male and female HAP2 and LAP2 mice...
  25. Webster B, Colombi P, Jäger J, Lusk C. Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4. Cell. 2014;159:388-401 pubmed publisher
    ..Surveillance is mediated by Heh2, a member of the LEM (Lap2-emerin-MAN1) family of integral inner nuclear membrane proteins, which binds to an early NPC assembly intermediate, ..
  26. Lachapelle S, Gagné J, Garand C, Desbiens M, Coulombe Y, Bohr V, et al. Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples. J Proteome Res. 2011;10:1216-27 pubmed publisher
    ..Among the top 15 hits, we find the new interactors TMPO, HNRNPU, RPS3, RALY, RPS9 DDX21, and HNRNPM...
  27. Herrada I, Bourgeois B, Samson C, Buendia B, Worman H, Zinn Justin S. Purification and Structural Analysis of LEM-Domain Proteins. Methods Enzymol. 2016;569:43-61 pubmed publisher
    b>LAP2-emerin-MAN1 (LEM)-domain proteins are modular proteins characterized by the presence of a conserved motif of about 50 residues...
  28. Barateau A, Vadrot N, Vicart P, Ferreiro A, Mayer M, Heron D, et al. A Novel Lamin A Mutant Responsible for Congenital Muscular Dystrophy Causes Distinct Abnormalities of the Cell Nucleus. PLoS ONE. 2017;12:e0169189 pubmed publisher
    ..periphery, altering the anchorage of the inner nuclear membrane protein emerin and the nucleoplasmic protein LAP2-alpha...
  29. Li D, Ainiwaer J, Sheyhiding I, Zhang Z, Zhang L. Identification of key long non-coding RNAs as competing endogenous RNAs for miRNA-mRNA in lung adenocarcinoma. Eur Rev Med Pharmacol Sci. 2016;20:2285-95 pubmed
    ..features, while nine DELs (LINC00115, LINC00265, LINC01001, LINC01002, MIR22HG, NFYC-AS1, SNHG10, THUMPD3-AS1 and TMPO-AS1) were revealed to be prognostic biomarkers...
  30. Gu M, LaJoie D, Chen O, von Appen A, Ladinsky M, Redd M, et al. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Proc Natl Acad Sci U S A. 2017;114:E2166-E2175 pubmed publisher
    ..Here, we report that Lem2p (LEM2), a member of the LEM (Lap2-Emerin-Man1) family of inner nuclear membrane proteins, and the ESCRT-II/ESCRT-III hybrid protein Cmp7p (CHMP7), ..
  31. Yang L, Guan T, Gerace L. Lamin-binding fragment of LAP2 inhibits increase in nuclear volume during the cell cycle and progression into S phase. J Cell Biol. 1997;139:1077-87 pubmed
    Lamina-associated polypeptide 2 (LAP2) is an integral membrane protein of the inner nuclear membrane that binds to both lamin B and chromatin and has a putative role in nuclear envelope (NE) organization...
  32. Peng F, Wang R, Zhang Y, Zhao Z, Zhou W, Chang Z, et al. Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma. Mol Cancer. 2017;16:98 pubmed publisher
    ..the individual-level DE lncRNAs, we developed a robust prognostic signature consisting of two lncRNA (C1orf132 and TMPO-AS1) for stage I-II LUAD patients without adjuvant therapy (P = 3...
  33. Barton L, Lovander K, Pinto B, Geyer P. Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin. Dev Biol. 2016;415:75-86 pubmed publisher
    ..This network includes the LAP2-emerin-MAN1-domain (LEM-D) protein family, proteins that share an association with the chromatin binding protein ..
  34. Wang T, Zhao M, Liang D, Bose U, Kaur S, McManus D, et al. Changes in the neuropeptide content of Biomphalaria ganglia nervous system following Schistosoma infection. Parasit Vectors. 2017;10:275 pubmed publisher
    ..A hub with most connections for both non-infected and infected Biomphalaria includes leucine aminopeptidase 2 (LAP2), which interacts with numerous miracidia proteins that together belong to the immunoglobulin family of cell ..
  35. Dubińska Magiera M, Chmielewska M, Kozioł K, Machowska M, Hutchison C, Goldberg M, et al. Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability. Protoplasma. 2016;253:943-56 pubmed publisher
    Xenopus LAP2β protein is the single isoform expressed in XTC cells. The protein localizes on heterochromatin clusters both at the nuclear envelope and inside a cell nucleus...
  36. Naetar N, Ferraioli S, Foisner R. Lamins in the nuclear interior - life outside the lamina. J Cell Sci. 2017;130:2087-2096 pubmed publisher
    ..modifications and interactions with nucleoplasmic proteins, such as lamina-associated polypeptide 2α (LAP2α; encoded by TMPO)...
  37. Snyers L, Erhart R, Laffer S, Pusch O, Weipoltshammer K, Schöfer C. LEM4/ANKLE-2 deficiency impairs post-mitotic re-localization of BAF, LAP2? and LaminA to the nucleus, causes nuclear envelope instability in telophase and leads to hyperploidy in HeLa cells. Eur J Cell Biol. 2018;97:63-74 pubmed publisher
    ..LEM-domain proteins LAP2, emerin and MAN1 are proteins of the inner nuclear membrane; they have important functions: maintaining the ..
  38. Fader A, Java J, Tenney M, Ricci S, Gunderson C, Temkin S, et al. Impact of histology and surgical approach on survival among women with early-stage, high-grade uterine cancer: An NRG Oncology/Gynecologic Oncology Group ancillary analysis. Gynecol Oncol. 2016;143:460-465 pubmed publisher
    ..and survival outcomes of women with high-grade uterine cancer (UC) enrolled on The Gynecologic Oncology Group (GOG) LAP2 trial...
  39. Bartova E, Legartova S, Krejci J, Řezníčková P, Kovaříková A, Suchankova J, et al. Depletion of A-type lamins and Lap2? reduces 53BP1 accumulation at UV-induced DNA lesions and Lap2? protein is responsible for compactness of irradiated chromatin. J Cell Biochem. 2018;: pubmed publisher
    We studied how deficiency in lamins A/C and lamina-associated polypeptide 2? (Lap2?) affects DNA repair after irradiation...
  40. Santos J, Duarte N, Kehrer J, Ramesar J, Avramut M, Koster A, et al. Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite. Proc Natl Acad Sci U S A. 2016;113:7183-8 pubmed publisher
    ..gametocytes, is activated translationally during ookinete formation, where the protein is essential for the formation of the crystalloid, the correct targeting of crystalloid-resident protein LAP2, and malaria parasite transmission.
  41. Tremp A, Sharma V, Carter V, Lasonder E, Dessens J. LCCL protein complex formation in Plasmodium is critically dependent on LAP1. Mol Biochem Parasitol. 2017;214:87-90 pubmed publisher
    ..Our results show that abundant complexes containing LAP1, LAP2 and LAP3 are formed in gametocytes through high avidity interactions...
  42. Webster B, Thaller D, Jager J, Ochmann S, Borah S, Lusk C. Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing. EMBO J. 2016;35:2447-2467 pubmed
    ..Recruitment to sites of NPC assembly is mediated by its ESCRT-II domain and the LAP2-emerin-MAN1 (LEM) family of integral inner nuclear membrane proteins, Heh1 and Heh2...
  43. Gesson K, Rescheneder P, Skoruppa M, von Haeseler A, Dechat T, Foisner R. A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha. Genome Res. 2016;26:462-73 pubmed publisher
    ..Loss of lamin A/C in heterochromatic regions in LAP2alpha-deficient cells, however, correlated with increased gene expression. Our data show a novel role of nucleoplasmic lamin A/C and LAP2alpha in regulating euchromatin. ..
  44. Craig D, Millis M, DiStefano J. Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes. Diabet Med. 2009;26:1090-8 pubmed publisher
    ..91) per copy of C allele; P = 1.6 x 10(-5)]. Evidence for nominal association with markers in or near the IRS2, TMPO, BID, KLRA1, ELMO1 and CNDP1 genes was also observed (P < or = 0.0006)...
  45. Shaklai S, Somech R, Gal Yam E, Deshet Unger N, Moshitch Moshkovitz S, Hirschberg K, et al. LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression. Eur J Cell Biol. 2008;87:267-78 pubmed publisher
    ..We now show that LAP2zeta, the smallest LAP2 family member, is also involved in regulation of transcription...
  46. Fuccello A, Audhya T, Talle M, Goldstein G. Immunoassay for bovine serum thymopoietin: discrimination from splenin by monoclonal antibodies. Arch Biochem Biophys. 1984;228:292-8 pubmed
    A polyclonal rabbit anti-bovine thymopoietin antiserum was used to develop a radioimmunoassay and sandwich enzyme-linked immunosorbent (ELISA) assay for the thymic hormone thymopoietin...
  47. Zhang S, Schones D, Malicet C, Rochman M, Zhou M, Foisner R, et al. High mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2? (LAP2?) interact and reciprocally affect their genome-wide chromatin organization. J Biol Chem. 2013;288:18104-9 pubmed publisher
    ..domain of the nucleosome-binding protein HMGN5 interacts with the C-terminal domain of the lamin-binding protein LAP2? and that these proteins reciprocally alter their interaction with chromatin...
  48. WARD M, van der Watt P, Tzoneva G, Leaner V. Deregulated LAP2? expression in cervical cancer associates with aberrant E2F and p53 activities. IUBMB Life. 2011;63:1018-26 pubmed publisher
    Lamina-associated polypeptide 2 alpha (LAP2?) plays a role in maintaining nuclear structure, in nuclear assembly/disassembly, and in transcriptional regulation...
  49. Guro H, Cho J, Han H, Yoon Y, Choi Y, Jang J, et al. Laparoscopic liver resection of hepatocellular carcinoma located in segments 7 or 8. Surg Endosc. 2018;32:872-878 pubmed publisher was subdivided into two subgroups according to whether LLR was performed before (Lap1; n = 29) or after (Lap2; n = 17) the introduction of the Pringle maneuver, intercostal trocars, and semi-lateral patient positioning...
  50. Qi R, Xu N, Wang G, Ren H, Li S, Lei J, et al. The lamin-A/C-LAP2α-BAF1 protein complex regulates mitotic spindle assembly and positioning. J Cell Sci. 2015;128:2830-41 pubmed publisher
    ..Here, we report that a fraction of the nuclear periphery proteins lamin-A/C, LAP2α and BAF1 (also known as BANF1) relocate to the spindle and the cell cortex in mitosis...
  51. Tifft K, Bradbury K, Wilson K. Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases. J Cell Sci. 2009;122:3780-90 pubmed publisher
    ..These findings suggest roles for emerin as a downstream effector and ;signal integrator' for tyrosine kinase signaling pathway(s) at the nuclear envelope. ..
  52. Laguri C, Gilquin B, Wolff N, Romi Lebrun R, Courchay K, Callebaut I, et al. Structural characterization of the LEM motif common to three human inner nuclear membrane proteins. Structure. 2001;9:503-11 pubmed
    ..In particular, all LAP2 isoforms share an N-terminal segment composed of such a LEM domain that is connected to a highly divergent LEM-like ..
  53. Sand Dejmek J, Adelmant G, Sobhian B, Calkins A, Marto J, Iglehart D, et al. Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin. Mol Cancer. 2011;10:74 pubmed publisher
    ..Silencing FACT however, allows both apoptosis and necrosis. Targeting DNA repair in cancer patients may have different therapeutic effects depending upon the roles played by factors targeted. ..
  54. Harris C, Andryuk P, Cline S, Mathew S, Siekierka J, Goldstein G. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. Genomics. 1995;28:198-205 pubmed
    ..TMPO beta appears to be the human homologue of the recently described rat protein LAP2 (lamina-associated polypeptide 2), which is thought to play an important role in the regulation of nuclear ..
  55. Zhang L, Wang G, Chen S, Ding J, Ju S, Cao H, et al. Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells. World J Surg Oncol. 2016;14:267 pubmed
    Glioblastoma (GBM) is the most malignant nervous system tumor with an almost 100 % recurrence rate. Thymopoietin (TMPO) has been demonstrated to be upregulated in various tumors, including lung cancer, breast cancer, and so on, but its ..
  56. Martins S, Eikvar S, Furukawa K, Collas P. HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication. J Cell Biol. 2003;160:177-88 pubmed
    ..Precipitation of GST-LAP2 beta fusion proteins and overlays of immobilized HA95 indicate that a first HA95-binding region lies within amino ..
  57. Prüfert K, Winkler C, Paulin Levasseur M, Krohne G. The lamina-associated polypeptide 2 (LAP2) genes of zebrafish and chicken: no LAP2alpha isoform is synthesised by non-mammalian vertebrates. Eur J Cell Biol. 2004;83:403-11 pubmed
    The mammalian lamina-associated polypeptide 2 (LAP2) gene encodes six isoforms (LAP2alpha, beta, delta, epsilon, gamma, zeta) that are synthesised from alternatively spliced mRNAs...
  58. Snyers L, Vlcek S, Dechat T, Skegro D, Korbei B, Gajewski A, et al. Lamina-associated polypeptide 2-alpha forms homo-trimers via its C terminus, and oligomerization is unaffected by a disease-causing mutation. J Biol Chem. 2007;282:6308-15 pubmed
    ..Finally, we show that, in contrast to the LAP2alpha-lamin A interaction, its self-association is not affected by a disease-linked single point mutation in the LAP2alpha C terminus. ..
  59. Shanbhogue V, Hansen S, Jørgensen N, Beck Nielsen S. Impact of Conventional Medical Therapy on Bone Mineral Density and Bone Turnover in Adult Patients with X-Linked Hypophosphatemia: A 6-Year Prospective Cohort Study. Calcif Tissue Int. 2018;102:321-328 pubmed publisher
    ..The renal tubular reabsorption of PO4 (TmPO4/GFR) was calculated at both time points...
  60. Shao W, Zumer K, Fujinaga K, Peterlin B. FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). J Biol Chem. 2016;291:17953-63 pubmed publisher
    ..Because P-TEFb is required for the transition from initiation to elongation of transcription, this interaction ensures proper expression of AIRE-responsive tissue-specific antigens in the thymus. ..
  61. Somech R, Gal Yam E, Shaklai S, Geller O, Amariglio N, Rechavi G, et al. Enhanced expression of the nuclear envelope LAP2 transcriptional repressors in normal and malignant activated lymphocytes. Ann Hematol. 2007;86:393-401 pubmed
    ..integral nuclear membrane proteins, such as the alternative spliced isoforms of lamina-associated polypeptide 2 (LAP2), have been shown to be important for the initiation of replication and repression of transcription...
  62. Li P, Meinke P, Huong L, Wehnert M, Noegel A. Contribution of SUN1 mutations to the pathomechanism in muscular dystrophies. Hum Mutat. 2014;35:452-61 pubmed publisher
    ..Moreover, SUN1 of both patient fibroblasts exhibited reduced interaction with Lamin A/C and when expressed ectopically in wild-type fibroblasts, the SUN1 mutant proteins exhibited reduced interactions with Emerin as well. ..
  63. Bishop E, Java J, Moore K, Spirtos N, Pearl M, Zivanovic O, et al. Surgical outcomes among elderly women with endometrial cancer treated by laparoscopic hysterectomy: a NRG/Gynecologic Oncology Group study. Am J Obstet Gynecol. 2018;218:109.e1-109.e11 pubmed publisher
    ..Laparoscopic Surgery or Standard Surgery in Treating Patients With Endometrial Cancer or Cancer of the Uterus (LAP2) trial...
  64. Twomey J, Goldstein G, Lewis V, Bealmear P, Good R. Bioassay determinations of thymopoietin and thymic hormone levels in human plasma. Proc Natl Acad Sci U S A. 1977;74:2541-5 pubmed
    b>Thymopoietin is a thymic hormone that induces differentiation of thymocytes from precursor cells which arise in hemopoietic tissues. This paper describes a sensitive in vitro assay for the induction of Thy 1...
  65. Loi M, Cenni V, Duchi S, Squarzoni S, Lopez Otin C, Foisner R, et al. Barrier-to-autointegration factor (BAF) involvement in prelamin A-related chromatin organization changes. Oncotarget. 2016;7:15662-77 pubmed publisher
    ..BAF is necessary to induce histone trimethyl-H3K9 as well as HP1-alpha and LAP2-alpha nuclear relocalization in response to prelamin A accumulation...
  66. Dechat T, Vlcek S, Foisner R. Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics. J Struct Biol. 2000;129:335-45 pubmed
    ..Recent studies using mutant proteins have just begun to unravel functions of LAP2 isoforms during postmitotic nuclear reassembly...
  67. Parise P, Finocchiaro G, Masciadri B, Quarto M, Francois S, Mancuso F, et al. Lap2alpha expression is controlled by E2F and deregulated in various human tumors. Cell Cycle. 2006;5:1331-41 pubmed
    ..Here we report that the expression of LAP2 (lamina-associated polypeptide 2) is under direct control of E2F transcription factors...
  68. Hansberg Pastor V, González Arenas A, Camacho Arroyo I. CCAAT/enhancer binding protein ? negatively regulates progesterone receptor expression in human glioblastoma cells. Mol Cell Endocrinol. 2017;439:317-327 pubmed publisher
    ..expression regulation in glioblastoma cell lines, which expressed different ratios of PR and C/EBP? isoforms (LAP1, LAP2, and LIP)...
  69. Weber P, Eckhard C, Gonser S, Otto H, Folkers G, Beck Sickinger A. On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family. Biol Chem. 1999;380:653-60 pubmed
    ..The recent isolation and characterization of seven mouse TMPO mRNA transcripts named TMPO-alpha, beta, beta', gamma, epsilon delta and zeta, suggest that more than the three ..
  70. Marrero Rodríguez D, Taniguchi Ponciano K, Lopez Sleman J, Romero Morelos P, Mendoza Rodríguez M, Garcia I, et al. Thymopoietin Beta and Gamma Isoforms as a Potential Diagnostic Molecular Marker for Breast Cancer: Preliminary Data. Pathol Oncol Res. 2015;21:1045-50 pubmed publisher
    b>Thymopoietin (TMPO) is an inner nuclear membrane protein, the coding gene named equally, can give arise to six isoforms by alternative splicing. This gene has been found up regulated in several types of cancer...
  71. Ju W, Brown W, Zhong N. Association of progerin-interactive partner proteins with lamina proteins: Mel18 is associated with emerin in HGPS. Beijing Da Xue Xue Bao Yi Xue Ban. 2009;41:397-401 pubmed
    ..An association of Mel18 with emerin was observed in HGPS, but not in WT cells. Based on these findings, we propose that PIPPs, along with associated lamina proteins may form a pathogenic progerin-containing protein complex. ..
  72. Heavner G, Audhya T, Goldstein G. Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines. Regul Pept. 1990;27:257-62 pubmed
    b>Thymopoietin, a polypeptide hormone of the thymus, and the synthetic pentapeptide thymopentin, corresponding to thymopoietin32-36, both induced elevations of intracellular cyclic GMP in two human T cell lines, CEM and MOLT-4...
  73. Naetar N, Hutter S, Dorner D, Dechat T, Korbei B, Gotzmann J, et al. LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit. J Cell Sci. 2007;120:737-47 pubmed
    ..Our data show a role of LINT-25 and LAP2alpha during cell cycle exit, in which LINT-25 acts upstream of LAP2alpha. ..
  74. Pekovic V, Harborth J, Broers J, Ramaekers F, van Engelen B, Lammens M, et al. Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts. J Cell Biol. 2007;176:163-72 pubmed
    ..Our results suggest that LAP2alpha and lamin A/C are involved in controlling Rb localization and phosphorylation, and a lack or mislocalization of either protein leads to cell cycle arrest in HDFs...
  75. Lemchak D, Banerjee S, Digambar S, Hood B, Conrads T, Jedrych J, et al. Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and sezary syndrome. Exp Dermatol. 2017;: pubmed publisher
    ..Hsp70 member 1A (HSPA1A), ATP-depending RNA-helicase (DDX17), and the ? isoform of lamina-associated polypeptide 2 (TMPO) had higher expression in aggressive disease versus non-aggressive...
  76. Martins S, Marstad A, Collas P. In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling. Biochemistry. 2003;42:10456-61 pubmed
    ..This suggests an additional level of regulation of a chromatin-nuclear envelope interaction in dividing cells. ..
  77. Chojnowski A, Ong P, Wong E, Lim J, Mutalif R, Navasankari R, et al. Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria. elife. 2015;4: pubmed publisher
    ..Here, we describe an inducible cellular system to model HGPS and find that LAP2α (lamina-associated polypeptide-α) interacts with lamin A, while its interaction with progerin is ..
  78. Hara H, Hayashi K, Ohta K, Itoh N, Ohta M. A new thymopoietin precursor gene from human thymus. Biochem Mol Biol Int. 1994;34:927-33 pubmed
    b>Thymopoietin-related peptide (TPRP) gene was identified and cloned from a human thymus cDNA library. The cloned cDNA encoded a mature TPRP including the active site of thymopoietin (TP) (residues 32-36)...
  79. Vidak S, Kubben N, Dechat T, Foisner R. Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins. Genes Dev. 2015;29:2022-36 pubmed publisher
    Lamina-associated polypeptide 2α (LAP2α) localizes throughout the nucleoplasm and interacts with the fraction of lamins A/C that is not associated with the peripheral nuclear lamina...