TMEM18

Summary

Gene Symbol: TMEM18
Description: transmembrane protein 18
Species: human

Top Publications

  1. pmc Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
  2. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
  3. doi Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese
    Maggie C Y Ng
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Endocrinol Metab 95:2418-25. 2010
  4. pmc Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    Frida Renstrom
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    Hum Mol Genet 18:1489-96. 2009
  5. doi β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals
    Mette Thomsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 97:E1074-9. 2012
  6. pmc Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA
    C Holzapfel
    Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, Munich, Germany
    Int J Obes (Lond) 34:1538-45. 2010
  7. doi Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 18:1212-7. 2010
  8. pmc The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
    Markus Sällman Almén
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Uppsala SE 75124, Sweden
    BMC Med Genet 11:58. 2010
  9. doi Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells
    Jaana Jurvansuu
    Institute of Bioengineering and Nanotechnology, Departments of Biological Sciences, National University of Singapore
    Cancer Res 68:4614-22. 2008
  10. doi MC4R variant is associated with BMI but not response to resistance training in young females
    Funda E Orkunoglu-Suer
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Obesity (Silver Spring) 19:662-6. 2011

Scientific Experts

  • André Scherag
  • Kikuko Hotta
  • Stella Aslibekyan
  • Unhee Lim
  • Sungshim Lani Park
  • Michael J Williams
  • Mariaelisa Graff
  • Ineta Kalnina
  • Jian Gong
  • Jonathan A Mitchell
  • Jaana M Jurvansuu
  • Christina Holzapfel
  • Funda E Orkunoglu-Suer
  • Ruth J F Loos
  • Nicholas J Wareham
  • Ken K Ong
  • Jianhua Zhao
  • Cathy E Elks
  • Shengxu Li
  • Kay Tee Khaw
  • Jing Hua Zhao
  • Sandra Deliard
  • Joseph T Glessner
  • Edward C Frackelton
  • Jonathan P Bradfield
  • Robert I Berkowitz
  • Rosetta M Chiavacci
  • Hakon Hakonarson
  • Struan F A Grant
  • Haitao Zhang
  • Cecilia E Kim
  • Stephen J Sharp
  • Robert N Luben
  • Susan M Ring
  • Andrew R Ness
  • George Davey Smith
  • Ines Barroso
  • Florianne Bauer
  • John R Speakman
  • F Bernhard
  • Ioanna Ntalla
  • A Prats-Puig
  • Stefan Stender
  • L Dusátková
  • Yaroslav Winter
  • Børge G Nordestgaard
  • Hao Huang
  • Rebekah Karns
  • Hao Mei
  • R Dorajoo
  • Mathias Rask-Andersen
  • K W Hong
  • Ruth Gutierrez-Aguilar
  • Konstantinos Rouskas
  • J Wang
  • J M Hester
  • Mette Thomsen
  • Erin N Smith
  • Kai Wang
  • Josefin A Jacobsson
  • Eleftheria Zeggini
  • Ryan J Delahanty
  • Helgi B Schioth
  • Robert Fredriksson
  • Wei Chen
  • Johan Alsiö
  • Gerald S Berenson
  • Hannah S Mumby
  • Markus Sällman Almén
  • Axel Haupt
  • Maggie C Y Ng
  • Marek K Brandys
  • Marcel den Hoed
  • Mingyao Li
  • Marjo Riitta Jarvelin
  • Unnur Thorsteinsdottir
  • David Schlessinger
  • Luigi Ferrucci
  • Michael N Weedon
  • Dawn M Waterworth
  • Stephen J Chanock
  • Fernando Rivadeneira
  • Peter Kraft
  • Kate Northstone
  • Thorunn Rafnar
  • Gerard Waeber
  • Jian An Luan
  • Manuela Uda
  • Nicole Soranzo
  • Wendy L McArdle

Detail Information

Publications55

  1. pmc Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
    ..We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant)...
  2. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
    ..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity...
  3. doi Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese
    Maggie C Y Ng
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Endocrinol Metab 95:2418-25. 2010
    ..Recent genome-wide association studies have identified multiple novel loci associated with obesity in Europeans. We hypothesized that these genetic variants may be associated with obesity and type 2 diabetes (T2D) in Chinese...
  4. pmc Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    Frida Renstrom
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    Hum Mol Genet 18:1489-96. 2009
    Recent genome-wide association studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1)...
  5. doi β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals
    Mette Thomsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 97:E1074-9. 2012
    ..The rare functional ADRB2rs1800888(Thr164Ile) polymorphism could therefore influence risk of obesity and subsequently diabetes...
  6. pmc Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA
    C Holzapfel
    Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, Munich, Germany
    Int J Obes (Lond) 34:1538-45. 2010
    ..It was consecutively hypothesized that these associations might be evoked by a modulation of nutritional intake or energy expenditure...
  7. doi Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 18:1212-7. 2010
    ..We genotyped 1,469 nondiabetic subjects for the single-nucleotide polymorphisms (SNPs) TMEM18 rs6548238, KCTD15 rs11084753, GNPDA2 rs10938397, SH2B1 rs7498665, MTCH2 rs10838738, and NEGR1 rs2815752...
  8. pmc The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
    Markus Sällman Almén
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Uppsala SE 75124, Sweden
    BMC Med Genet 11:58. 2010
    b>TMEM18 is a hypothalamic gene that has recently been linked to obesity and BMI in genome wide association studies. However, the functional properties of TMEM18 are obscure.
  9. doi Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells
    Jaana Jurvansuu
    Institute of Bioengineering and Nanotechnology, Departments of Biological Sciences, National University of Singapore
    Cancer Res 68:4614-22. 2008
    ..Here, we show that a previously unannotated gene, the one encoding transmembrane protein 18 (TMEM18), is one such gene...
  10. doi MC4R variant is associated with BMI but not response to resistance training in young females
    Funda E Orkunoglu-Suer
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Obesity (Silver Spring) 19:662-6. 2011
    ..in a cohort (n = 796) that undertook a 12-week resistance-training program. Females with a copy of the rare allele (C) for rs17782313 (MC4R) had significantly higher BMIs (..
  11. pmc Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood
    Hao Mei
    Department of Epidemiology, Tulane University, New Orleans, Louisiana, United States of America
    PLoS ONE 7:e31470. 2012
    ..6*10-4). These 12 SNPs are located at or near genes either expressed in the brain (BDNF, KCTD15, TMEM18, MTCH2, and FTO) or implicated in cell apoptosis and proliferation (FAIM2, MAP2K5, and TFAP2B)...
  12. pmc Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health
    M Graff
    1 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA 2 Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA
    Nutr Diabetes 2:e47. 2012
    ..05; effect sizes from 0.19 to 0.71 kg m(-2) increase in BMI per effect allele), while 4 (FTO, TMEM18, TFAP2B, MC4R) remained significant after Bonferroni correction (P<0.0015)...
  13. pmc Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network
    S Aslibekyan
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, RPHB 217G, Birmingham, AL 35294, USA Electronic address
    Nutr Metab Cardiovasc Dis 23:987-94. 2013
    ..This is the first genome-wide association study of fenofibrate effects on circulating adiponectin...
  14. doi What model organisms and interactomics can reveal about the genetics of human obesity
    Michael J Williams
    Department of Neuroscience, Functional Pharmacology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Cell Mol Life Sci 69:3819-34. 2012
    ..DNAJC27, SLC39A8, MTIF3, RPL27A, SEC16B, ETV5, HMGA1, TFAP2B, TUB, ZNF608, FAIM2, KCTD15, LINGO2, POC5, PTBP2, TMEM18, TMEM160). We find that the majority have orthologues in distant species, such as D. melanogaster and C...
  15. pmc Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies
    Unhee Lim
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    Int J Cancer 131:E1038-43. 2012
    ..in 15 loci (BDNF, FAIM2, FTO, GNPDA2, KCTD15, LYPLAL1, MC4R, MSRA, MTCH2, NEGR1, NRXN3, SEC16B, SH2B1, TFAP2B and TMEM18) were genotyped in a case-control study of 2,033 colorectal cancer cases and 9,640 controls nested within the ..
  16. doi Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty
    J Wang
    Department of Laboratory Medicine, Shanghai Children s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    Int J Obes (Lond) 36:542-7. 2012
    ..To address this question, we conducted a study that aims to examine effects of eight previously reported GWAS single-nucleotide polymorphisms (SNPs) on four obesity-related indices in a sample of Chinese children aged 10-12 years...
  17. pmc Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia
    Rebekah Karns
    Center for Genome Information, Department of Environmental Health, University of Cincinnati, and Cincinnati Children s Hospital, Cincinnati, OH 45267, USA
    Ann Hum Genet 76:121-7. 2012
    ..In addition, we identified several novel loci suggestive of association with uric acid levels (SEMA5A, TMEM18, SLC28A2, and ODZ2), although the P-values (P<5×10(-6)) did not reach the threshold of genome-wide ..
  18. doi Variations in the obesity genes FTO, TMEM18 and NRXN3 influence the vulnerability of children to weight gain induced by short sleep duration
    A Prats-Puig
    Pediatrics Research Group, Girona Institute for Biomedical Research, Girona, Spain
    Int J Obes (Lond) 37:182-7. 2013
    Shorter sleep duration predisposes to obesity, but the mechanisms whereby sleep deprivation affects body weight are poorly understood. We tested whether this association is modulated by the obesity genes FTO, TMEM18 and NRXN3.
  19. doi Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology
    F Bernhard
    Center for Pediatric Research, Hospital for Children and Adolescents, Department of Women s and Child Health, University of Leipzig, Liebigstraße 21, Leipzig, Germany
    Diabetologia 56:311-22. 2013
    ..We investigated the functional relevance of such genes in human adipocytes...
  20. pmc The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study
    Mariaelisa Graff
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 62:1763-7. 2013
    ..evidence for heterogeneity in the associations of five established obesity risk variants (near FTO, GNPDA2, MTCH2, TMEM18, and NEGR1) with BMI across four distinct epochs of adulthood: 1) young adulthood (ages 18-25 years), adulthood (..
  21. pmc Replication of established common genetic variants for adult BMI and childhood obesity in Greek adolescents: the TEENAGE study
    Ioanna Ntalla
    Harokopio University of Athens, Department of Nutrition and Dietetics, 17671 Athens, Greece
    Ann Hum Genet 77:268-74. 2013
    ..Variants at the FTO, TMEM18, FAIM2, RBJ, ZNF608 and QPCTL loci yielded nominal evidence for association with BMI and/or overweight risk (p <..
  22. pmc Fine Mapping and Identification of BMI Loci in African Americans
    Jian Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA Electronic address
    Am J Hum Genet 93:661-71. 2013
    ..Eight of the 21 loci (SEC16B, TMEM18, ETV5, GNPDA2, TFAP2B, BDNF, FTO, and MC4R) were found to be associated with BMI in AAs at 5.8 × 10(-5)...
  23. doi Functional analysis of seven genes linked to body mass index and adiposity by genome-wide association studies: a review
    John R Speakman
    Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, PR China Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
    Hum Hered 75:57-79. 2013
    ..The remaining 7 SNPs are adjacent to, or within, the genes NEGR1, TMEM18, ETV5, FLJ35779, LINGO2, SH2B1 and GIPR, most of which are less well studied than FTO, particularly in the context ..
  24. ncbi Association of obesity susceptibility gene variants with metabolic syndrome and related traits in 1,443 czech adolescents
    L Dusátková
    Institute of Endocrinology, Obesity Management Centre, Prague, Czech Republic
    Folia Biol (Praha) 59:123-33. 2013
    ..We performed a study of eleven variants in/near genes TMEM18, SH2B1, KCTD15, PCSK1, BDNF, SEC16B, MC4R, and FTO in Czech adolescents and analysed their association with ..
  25. doi Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes
    Ineta Kalnina
    Latvian Biomedical Research and Study Centre, Ratsupites Street 1, LV 1067 Riga, Latvia
    Gene 527:462-8. 2013
    Variations in the FTO gene and near the TMEM18 gene are risk factors for common form of obesity, but have also been linked with type 2 diabetes (T2D)...
  26. pmc Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study
    Sungshim Lani Park
    Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
    Am J Epidemiol 178:780-90. 2013
    ..We investigated the associations between 6 obesity risk variants in (or near) the NEGR1, TMEM18, BDNF, FTO, MC4R, and KCTD15 genes and macronutrient intake (carbohydrate, protein, ethanol, and fat) in 3 ..
  27. doi Elevated body mass index as a causal risk factor for symptomatic gallstone disease: A Mendelian randomization study
    Stefan Stender
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Hepatology 58:2133-41. 2013
    ..were genotyped for three common variants known to associate with BMI: FTO(rs9939609); MC4R(rs17782313); and TMEM18(rs6548238). The number of BMI-increasing alleles was calculated for each participant...
  28. pmc The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry
    Sandra Deliard
    Division of Human Genetics, Research Institute, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:159-63. 2013
    ..at the loci harboring fat mass and obesity (FTO), melanocortin receptor 4 (MC4R), and transmembrane protein 18 (TMEM18) is consistently reported as being statistically most strongly associated with obesity...
  29. pmc Obesity-susceptibility loci and the tails of the pediatric BMI distribution
    Jonathan A Mitchell
    Center for Genetics and Complex Traits, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, USA
    Obesity (Silver Spring) 21:1256-60. 2013
    ..To determine whether previously identified adult obesity susceptibility loci were associated uniformly with childhood BMI across the BMI distribution...
  30. doi Genetic determinants of obesity and related vascular diseases
    Yaroslav Winter
    Department of Neurology, Philipps University, Marburg Germany
    Vitam Horm 91:29-48. 2013
    ..In addition to common variants, FTO and MC4R, new loci, such as TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2, and NEGR1 have been detected...
  31. doi Recapitulation of genome-wide association studies on body mass index in the Korean population
    K W Hong
    Department of Biomedical Engineering, School of Medicine, Kyung Hee University, Seoul, Korea
    Int J Obes (Lond) 36:1127-30. 2012
    ..BDNF), rs3817334 (MTCH2), rs1558902 (FTO), rs571312 (MC4R), rs543874 (SEC16B), rs987237 (TFAP2B), rs2867125 (TMEM18) and rs7138803 (FAIM2), were previously known obesity susceptibility loci, and the remaining four loci, rs1514175 (..
  32. doi Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 90:951-9. 2009
    ..New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake...
  33. pmc Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course
    Mariaelisa Graff
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA
    Hum Mol Genet 22:3597-607. 2013
    ..We identified seven independent loci (P < 5.0 × 10⁻⁸) near FTO (P = 3.72 × 10⁻²³), TMEM18 (P = 3.24 × 10⁻¹⁷), MC4R (P = 4.41 × 10⁻¹⁷), TNNI3K (P = 4.32 × 10⁻¹¹), SEC16B (P = 6...
  34. pmc Implication of European-derived adiposity loci in African Americans
    J M Hester
    Center for Diabetes Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 36:465-73. 2012
    ..Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans...
  35. pmc Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein
    Jaana M Jurvansuu
    Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e25317. 2011
    Transmembrane protein 18 (TMEM18) has previously been connected to cell migration and obesity. However, the molecular function of the protein has not yet been described...
  36. pmc Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies
    Marcel den Hoed
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 59:2980-8. 2010
    ..We examined associations of variants in these loci with anthropometric traits in children and adolescents...
  37. pmc First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study
    Christina Holzapfel
    Else Kröner Fresenius Centre for Nutritional Medicine, Technische Universitat Munchen, Munich, Germany
    J Epidemiol Community Health 65:174-6. 2011
    ..The aim of this study was to investigate two obesity-related loci--the transmembrane 18 (TMEM18) and the fat mass and obesity-associated (FTO) gene--for their association with educational level and per capita ..
  38. pmc Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
    Cathy E Elks
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Med 7:e1000284. 2010
    ..Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity...
  39. doi Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 56:716-9. 2011
    ..fat area (SFA), for the following single-nucleotide polymorphisms (SNPs): NEGR1 rs2815752, SEC16B rs10913469, TMEM18 rs6548238, ETV5 rs7647305, GNPDA2 rs10938397, BDNF rs6265 and rs925946, MTCH2 rs10838738, SH2B1 rs7498665, MAF ..
  40. pmc Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
    Andre Scherag
    Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    PLoS Genet 6:e1000916. 2010
    ..Apart from previously identified FTO, MC4R, and TMEM18, we detected two new loci for obesity: one in SDCCAG8 (serologically defined colon cancer antigen 8 gene; p = 1...
  41. doi Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
    Marek K Brandys
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:695-9. 2010
    ..The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN...
  42. doi Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
    Kikuko Hotta
    Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    J Hum Genet 54:727-31. 2009
    ..several genes, including neuronal growth regulator 1 (NEGR1), SEC16 homolog B (SCE16B), transmembrane protein 18 (TMEM18), ets variant 5 (ETV5), glucosamine-6-phosphate deaminase 2 (GNPDA2), prolactin (PRL), brain-derived neurotrophic ..
  43. doi Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
    ..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
  44. pmc Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
    Cathy E Elks
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 42:1077-85. 2010
    ..The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes ..
  45. doi Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations
    R Dorajoo
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
    Int J Obes (Lond) 36:159-63. 2012
    ..Recent genome-wide association studies (GWAS) have identified 38 obesity-associated loci among European populations. However, their contribution to obesity in other ethnicities is largely unknown...
  46. pmc Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study
    Ryan J Delahanty
    Vanderbilt Epidemiology Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    Am J Epidemiol 174:1115-26. 2011
    ..For consistent SNPs, the allelic odds ratios ranged from 1.15 to 1.29. These 7 loci are in the SEC16B/RASAL, TMEM18, MSRA, SOX6, MTCH2, FTO, and MC4R genes...
  47. doi SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents
    Andre Scherag
    Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    Obesity (Silver Spring) 20:466-70. 2012
    ..A recent meta-analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents...
  48. pmc Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats
    Mathias Rask-Andersen
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Uppsala, Sweden
    Eur J Hum Genet 20:192-7. 2012
    ..studies have shown a strong association of single-nucleotide polymorphisms (SNPs) in the near vicinity of the TMEM18 gene. The effects of the TMEM18-associated variants are more readily observed in children...
  49. doi Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 56:647-51. 2011
    ..obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1...
  50. doi Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology
    Ruth Gutierrez-Aguilar
    Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 20:306-12. 2012
    ..From a total of 19 genes analyzed, seven genes (ETV5, FTO, GNPDA2, KCTD15, TMEM18, MC4R, and SH2B1) were down-regulated in the hypothalamus of HFD compared to chow-fed rats...
  51. doi Role of BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:2436-9. 2011
    ..SNPs) yielded at least nominal evidence for association with common childhood obesity, namely at the FTO, TMEM18, NRXN3, MC4R, SEC16B, GNPDA2, TNNI3K, QPCTL, and BDNF loci...
  52. pmc Mendelian Randomisation Study of Childhood BMI and Early Menarche
    Hannah S Mumby
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285, Cambridge CB2 0QQ, UK
    J Obes 2011:180729. 2011
    ..DNA was genotyped for twelve BMI-associated common variants (in/near FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, ETV5, MTCH2, SEC16B, FAIM2 and SH2B1), and for each individual a "BMI-..
  53. doi Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population
    Konstantinos Rouskas
    Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Obesity (Silver Spring) 20:389-95. 2012
    ..We nominally replicated the association with obesity (BMI ≥30 kg/m(2)) of six SNPs in or near the FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 loci (1.28 ≤ odds ratio (OR) ≤ 1.35; 0.004 ≤ P ≤ 0.043)...
  54. doi Implication of genetic variants near TMEM18, BCDIN3D/FAIM2, and MC4R with coronary artery disease and obesity in Chinese: a angiography-based study
    Hao Huang
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People s Republic of China
    Mol Biol Rep 39:1739-44. 2012
    ..Three single nucleotide polymorphisms (SNPs) rs7561317 near TMEM18, rs7138803 near BCDIN3D/FAIM2 and rs12970134 near MC4R were examined in 930 Han Chinese subjects based on coronary ..
  55. pmc The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:2254-7. 2009
    ..at least nominally significant association to BMI, representing nine different loci including INSIG2, FTO, MC4R, TMEM18, GNPDA2, NEGR1, BDNF, KCTD15, and 1q25...