TLR7

Summary

Gene Symbol: TLR7
Description: toll like receptor 7
Alias: TLR7-like, toll-like receptor 7, toll-like receptor 7-like
Species: human
Products:     TLR7

Top Publications

  1. Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol. 2002;168:4531-7 pubmed
    ..High expression of TLR2 was characteristic for monocytes. PDC and B cells expressed marked levels of TLR7 and TLR9 and were directly sensitive to CpG ODN...
  2. García Ortiz H, Velázquez Cruz R, Espinosa Rosales F, Jiménez Morales S, Baca V, Orozco L. Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population. Ann Rheum Dis. 2010;69:1861-5 pubmed publisher
    ..Recent studies have shown that Tlr7 gene dosage has a significant contribution in the autoimmune-enhancing effect in mouse models of systemic lupus ..
  3. Lombardi V, Van Overtvelt L, Horiot S, Moingeon P. Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells. J Immunol. 2009;182:3372-9 pubmed publisher
    ..In this study, we report that a dual stimulation of TLR4 and TLR7/8 with LPS plus R848 leads human monocyte-derived DCs (MoDCs) to produce multiple pro- and anti-inflammatory ..
  4. Yu C, Peng W, Oldenburg J, Hoch J, Bieber T, Limmer A, et al. Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation. J Immunol. 2010;184:1159-67 pubmed publisher
    ..We demonstrated that PDCs are capable of promoting Th17 differentiation in response to TLR7 stimulation...
  5. Hwang S, Lee H, Yamamoto M, Jones L, Dayalan J, Hopkins R, et al. B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice. J Immunol. 2012;189:5786-96 pubmed publisher
    ..Recent data have highlighted an important role for the TLR family, particularly TLR7, in both human disease and murine models...
  6. Ito T, Amakawa R, Kaisho T, Hemmi H, Tajima K, Uehira K, et al. Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J Exp Med. 2002;195:1507-12 pubmed
    ..This study demonstrates that TLR-7 exerts its biological effect in a DC subset-specific manner. ..
  7. Møller Larsen S, Nyegaard M, Haagerup A, Vestbo J, Kruse T, Børglum A. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax. 2008;63:1064-9 pubmed publisher
    ..Xp22 harbours the TLR7 and TLR8 genes...
  8. Schott E, Witt H, Neumann K, Bergk A, Halangk J, Weich V, et al. Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. J Viral Hepat. 2008;15:71-8 pubmed
    ..As HCV is a single-stranded RNA virus, a role for TLR7 in the immune response against HCV is possible, and early clinical studies have demonstrated an antiviral effect of ..
  9. Berland R, Fernandez L, Kari E, Han J, Lomakin I, Akira S, et al. Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity. 2006;25:429-40 pubmed
    ..This autoantibody production was largely dependent on Toll-like receptor 7 (TLR7). We further show that production of these autoantibodies was sufficient to cause kidney pathology in these mice...

More Information

Publications80

  1. Shen N, Fu Q, Deng Y, Qian X, Zhao J, Kaufman K, et al. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2010;107:15838-43 pubmed publisher
    ..Previous findings that duplicated Toll-like receptor 7 (Tlr7) promotes lupus-like disease in male BXSB mice prompted us to evaluate TLR7 in human SLE...
  2. Schott E, Witt H, Neumann K, Taube S, Oh D, Schreier E, et al. A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection. J Hepatol. 2007;47:203-11 pubmed
    ..Since HCV is an RNA virus, a role for TLR7 in the immune response against HCV is likely...
  3. Guiducci C, Gong M, Xu Z, Gill M, Chaussabel D, Meeker T, et al. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature. 2010;465:937-41 pubmed publisher
    ..Recognition of self nucleic acids by toll-like receptors TLR7 and TLR9 on B cells and plasmacytoid dendritic cells (PDCs) is an important step in the pathogenesis of SLE, ..
  4. Yang K, Puel A, Zhang S, Eidenschenk C, Ku C, Casrouge A, et al. Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity. 2005;23:465-78 pubmed
    ..The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans. ..
  5. Askar E, Ramadori G, Mihm S. Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection. J Med Virol. 2010;82:1859-68 pubmed publisher
    ..Sensing of viral single-stranded RNA (ssRNA) by Toll-like receptor 7 (TLR7) is likely involved in early pathogen detection and host response to viral infections...
  6. Kelley J, Johnson M, Alarcon G, Kimberly R, Edberg J. Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects. Arthritis Rheum. 2007;56:3375-8 pubmed
    To determine whether there is an increase in the number of TLR7 gene copies in patients diagnosed as having systemic lupus erythematosus (SLE) and whether gene amplification influences the autoantibody profiles in SLE patients, as has ..
  7. Georgel P, Macquin C, Bahram S. The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes. PLoS ONE. 2009;4:e7803 pubmed publisher
    ..Hence this work depicts a first overview of the diversity of almost all human TLR genes, a prelude for large-scale population genetics as well as genetic association studies. ..
  8. Mansson A, Cardell L. Role of atopic status in Toll-like receptor (TLR)7- and TLR9-mediated activation of human eosinophils. J Leukoc Biol. 2009;85:719-27 pubmed publisher
    ..Herein, we investigated the expression and function of TLR7 and TLR9 in purified eosinophils from peripheral blood and assessed their role in allergic airway inflammation...
  9. Bochud P, Hersberger M, Taffe P, Bochud M, Stein C, Rodrigues S, et al. Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection. AIDS. 2007;21:441-6 pubmed
    ..To determine whether single-nucleotide polymorphisms (SNPs) in TLR2-4 and TLR7-9 influenced the natural course of HIV-1 infection...
  10. Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, et al. TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study. Arthritis Res Ther. 2011;13:R41 pubmed publisher
    The Toll-like receptor 7 (TLR7) gene, encoded on human chromosome Xp22.3, is crucial for type I interferon production...
  11. Kariko K, Buckstein M, Ni H, Weissman D. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity. 2005;23:165-75 pubmed
    ..We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity...
  12. Wang C, Eng H, Lin K, Chang C, Hsieh C, Lin Y, et al. TLR7 and TLR8 gene variations and susceptibility to hepatitis C virus infection. PLoS ONE. 2011;6:e26235 pubmed publisher
    ..We previously evaluated associations between TLR7 and TLR8 gene SNPs and susceptibility to hepatitis C virus (HCV) infection...
  13. Schoenemeyer A, Barnes B, Mancl M, Latz E, Goutagny N, Pitha P, et al. The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J Biol Chem. 2005;280:17005-12 pubmed
    ..we show that in contrast to IRF3 and IRF7, IRF5 is not a target of the TLR3 signaling pathway but is activated by TLR7 or TLR8 signaling...
  14. Chuang T, Ulevitch R. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw. 2000;11:372-8 pubmed
    ..Human TLR7-9, like the previously described members hTLR1-6 contain an ectodomain with multiple leucine-rich repeats (LRRs) ..
  15. Martin H, Lee J, Walls D, Hayward S. Manipulation of the toll-like receptor 7 signaling pathway by Epstein-Barr virus. J Virol. 2007;81:9748-58 pubmed
    ..Both UV-inactivated and untreated EBV upregulated the expression of TLR7 and downregulated the expression of TLR9 in naive B cells...
  16. Bauer S, Pigisch S, Hangel D, Kaufmann A, Hamm S. Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9. Immunobiology. 2008;213:315-28 pubmed publisher
    ..b>TLR7-9 recognize single-stranded RNA, nucleoside analogs and single-stranded CpG-DNA, respectively, and their activation ..
  17. Du X, Poltorak A, Wei Y, Beutler B. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw. 2000;11:362-71 pubmed
    We describe three novel genes, encoding members of the Toll-like receptor (Tlr) family (TLR7, TLR8, and TLR9). These Tlr family members, unlike others reported to date, were identified within a genomic database...
  18. dos Santos B, Valverde J, Rohr P, Monticielo O, Brenol J, Xavier R, et al. TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from southern Brazil. Lupus. 2012;21:302-9 pubmed publisher
    ..It is characterized by high production of autoantibodies against nuclear compounds. TLR7/8/9 are responsible for nucleic acid recognition and they trigger proinflammatory responses through activation of ..
  19. Horsmans Y, Berg T, Desager J, Mueller T, Schott E, Fletcher S, et al. Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology. 2005;42:724-31 pubmed
    ..Isatoribine is a selective agonist of TLR7. In a proof-of-concept study, we found that once-daily 7-day treatment with intravenous isatoribine 800 mg caused a ..
  20. Sanchez E, Callejas Rubio J, Sabio J, Gonzalez Gay M, Jimenez Alonso J, Mico L, et al. Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus. Clin Exp Rheumatol. 2009;27:267-71 pubmed
    The aim of this study was to evaluate the relevance of genetic variants of TLR5 (rs5744168) and TLR7 (rs179008) gene in systemic lupus erythematosus (SLE) in a Spanish population...
  21. Song Y, Zhuang Y, Zhai S, Huang D, Zhang Y, Kang W, et al. Increased expression of TLR7 in CD8(+) T cells leads to TLR7-mediated activation and accessory cell-dependent IFN-gamma production in HIV type 1 infection. AIDS Res Hum Retroviruses. 2009;25:1287-95 pubmed publisher
    ..In this study, we analyzed expression of TLR4, TLR5, TLR7, and TLR8 in CD8(+) T cells in HIV-1 infection...
  22. Chauhan S, Singh V, Rai R, Rai M, Rai G. Distinct autoantibody profiles in systemic lupus erythematosus patients are selectively associated with TLR7 and TLR9 upregulation. J Clin Immunol. 2013;33:954-64 pubmed publisher
    ..b>TLR7 and 9 protein expression was determined by western blotting in PBLs and by flow cytometry on B-cells and monocytes...
  23. Kaiser S, Rimbach K, Eigenbrod T, Dalpke A, Helm M. A modified dinucleotide motif specifies tRNA recognition by TLR7. RNA. 2014;20:1351-5 pubmed publisher
    ..The recognition of tRNA as either self or nonself RNA by TLR7 depends on its modification patterns...
  24. Jurk M, Heil F, Vollmer J, Schetter C, Krieg A, Wagner H, et al. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol. 2002;3:499 pubmed
  25. Chang S, Kodys K, Szabo G. Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells. Hepatology. 2010;51:35-42 pubmed publisher
    ..We hypothesize that HCV infection may interfere with the expression and/or function of TLR7, a sensor of single-stranded RNA...
  26. Di Domizio J, Blum A, Gallagher Gambarelli M, Molens J, Chaperot L, Plumas J. TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN. Blood. 2009;114:1794-802 pubmed publisher
    On recognition of influenza virus (Flu) by TLR7, plasmacytoid dendritic cells (pDCs) produce type I IFN in significant amounts...
  27. Zheng L, Zhang Z, Yu C, Yang C. Expression of Toll-like receptors 7, 8, and 9 in primary Sjögren's syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:844-50 pubmed publisher
    ..9 in peripheral mononuclear blood cells (PMBCs) from patients with primary Sjögren's syndrome (pSS) and whether TLR7 and 9 exist in the parotid glands of pSS patients...
  28. Cheng P, Eng H, Chou M, You H, Lin T. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. Transl Res. 2007;150:311-8 pubmed
    ..for the single nucleotide polymorphisms (SNPs) in TLRs associated with viral infection, including TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9...
  29. Hardy A, Graham D, Shearer G, Herbeuval J. HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha. Proc Natl Acad Sci U S A. 2007;104:17453-8 pubmed
    ..We also show that HIV-1-induced IKpDC depended on Toll-like receptor 7 (TLR7) activation...
  30. Lehmann S, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, et al. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci. 2012;15:827-35 pubmed publisher
    ..let-7 activates the RNA-sensing Toll-like receptor (TLR) 7 and induces neurodegeneration through neuronal TLR7. Cerebrospinal fluid (CSF) from individuals with Alzheimer’s disease contains increased amounts of let-7b, and ..
  31. Bekeredjian Ding I, Berkeredjian Ding I, Wagner M, Hornung V, Giese T, Schnurr M, et al. Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN. J Immunol. 2005;174:4043-50 pubmed
    ..In this study we identified a fundamental difference in the regulation of TLR7- and TLR9-mediated B cell stimulation: whereas the induction of polyclonal naive B cell proliferation by the TLR7 ..
  32. Deng Y, Zhao J, Sakurai D, Kaufman K, Edberg J, Kimberly R, et al. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet. 2013;9:e1003336 pubmed publisher
    We previously reported that the G allele of rs3853839 at 3'untranslated region (UTR) of Toll-like receptor 7 (TLR7) was associated with elevated transcript expression and increased risk for systemic lupus erythematosus (SLE) in 9,274 ..
  33. Rubtsov A, Rubtsova K, Fischer A, Meehan R, Gillis J, Kappler J, et al. Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c? B-cell population is important for the development of autoimmunity. Blood. 2011;118:1305-15 pubmed publisher
    ..We were able to detect a similar population of B cells in the peripheral blood of some elderly women with autoimmune disease, suggesting that there may be parallels between the creation of ABC-like cells between mice and humans. ..
  34. Hasimu A, Ge L, Li Q, Zhang R, Guo X. Expressions of Toll-like receptors 3, 4, 7, and 9 in cervical lesions and their correlation with HPV16 infection in Uighur women. Chin J Cancer. 2011;30:344-50 pubmed
    ..the role of TLRs expression in cervical carcinogenesis in Uighur women, we detected the expressions of TLR3, TLR4, TLR7, and TLR9 in 25 normal cervical tissues, 64 cervical intraepithelial neoplasia (CIN) tissues, and 63 cervical ..
  35. Mukherjee P, Winkler C, Taylor K, Woods T, Nair V, Khan B, et al. SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons. J Immunol. 2015;195:4913-21 pubmed publisher
    ..In the present study, we identified the mechanism responsible for TLR7/TLR9-mediated neuronal apoptosis...
  36. Niedzielska M, Raffi F, Tel J, Muench S, Jozefowski K, Alati N, et al. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production. J Immunol. 2015;195:1753-62 pubmed publisher
    Plasmacytoid dendritic cells (pDCs) efficiently produce large amounts of type I IFN in response to TLR7 and TLR9 ligands, whereas conventional DCs (cDCs) predominantly secrete high levels of the cytokines IL-10 and IL-12...
  37. Tsitoura D, Ambery C, Price M, Powley W, Garthside S, Biggadike K, et al. Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement. Clin Pharmacol Ther. 2015;98:369-80 pubmed publisher
    ..To explore this hypothesis, GSK2245035, a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties, was developed for intranasal application...
  38. Yamaguchi R, Sakamoto A, Yamaguchi R, Haraguchi M, Narahara S, Sugiuchi H, et al. Transcription factor specificity protein 1 modulates TGF?1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with substance P. Cytokine. 2018;108:24-36 pubmed publisher
    ..SP induced much greater SIGIRR protein production than either lipopolysaccharide (a TLR4 agonist) or resiquimod (a TLR7/8 agonist)...
  39. Liu F, Ji J, Li X, Li X, Xu J, Yue H, et al. Decreased CD1d level is associated with CD86 over-expression in B cells from systemic lupus erythematosus. Acta Biochim Biophys Sin (Shanghai). 2017;49:328-337 pubmed publisher
    ..in vitro experiments with splenocytes demonstrated that CD1d signaling pathway could inhibit toll-like receptor 7 (TLR7)-induced CD86 expression of B cells...
  40. Aichhorn S, Linhardt A, Halfmann A, Nadlinger M, Kirchberger S, Stadler M, et al. A pH-sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier. Chemistry. 2017;23:17721-17726 pubmed publisher
    ..designed to undergo intracellular pH-sensitive release of ImQs to induce inflammation through binding to endosomal TLR7/8 (danger signal)...
  41. Yang Q, Fu S, Wang J. Hepatitis C virus infection decreases the expression of Toll-like receptors 3 and 7 via upregulation of miR-758. Arch Virol. 2014;159:2997-3003 pubmed publisher
    ..Toll-like receptor 3 (TLR3) and Toll-like receptor 7 (TLR7) are pathogen-recognition receptors that are expressed on innate immune cells...
  42. Lyn Cook B, Xie C, Oates J, Treadwell E, Word B, Hammons G, et al. Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: ethnic differences and potential new targets for therapeutic drugs. Mol Immunol. 2014;61:38-43 pubmed publisher
    ..Increased expression in these lupus patients provides an opportunity for targeting with antagonist as a new therapy for systemic lupus erythematous. ..
  43. Berghöfer B, Haley G, Frommer T, Bein G, Hackstein H. Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-alpha production. J Immunol. 2007;178:4072-9 pubmed
    ..cells (pDCs) are unique with respect to their capacity to produce unsurpassed amounts of IFN-alpha and coexpress TLR7 and TLR9, mediating IFN-alpha production...
  44. Nilsson D, Andiappan A, Hallden C, De Yun W, Sall T, Tim C, et al. Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study. BMC Med Genet. 2012;13:66 pubmed
    ..The first association analysis identified 4 allergic rhinitis-associated SNPs in the TLR7-TLR8 gene region...
  45. Nie Z, Aboulnasr F, Natesampillai S, Burke S, Krogman A, Bren G, et al. Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment. J Immunol. 2018;200:1110-1123 pubmed publisher
    ..uninfected bystander cells, and that the dominant stimulus which induces TRAILshort production are type I IFNs and TLR7, TLR8, and TLR9 agonists...
  46. Fischetti L, Zhong Z, Pinder C, Tregoning J, Shattock R. The synergistic effects of combining TLR ligand based adjuvants on the cytokine response are dependent upon p38/JNK signalling. Cytokine. 2017;99:287-296 pubmed publisher
    ..cells and macrophages to three TLR ligands acting singly or in combination, Poly I:C (TLR3), GLA (TLR4) and R848 (TLR7/8)...
  47. Desnues B, Macedo A, Ordoñez Rueda D, Roussel Queval A, Malissen B, Bruhns P, et al. The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling. Eur J Immunol. 2016;46:2801-2811 pubmed publisher
    ..On the contrary, Genista mice deprived of TLR7 did not show any of these phenotypes, suggesting that the observed lupus autoimmunity in Genista mice is TLR7-..
  48. Huang Y, Shih H, Tiao M, Huang C, Kuo K, Huang F, et al. Toll-like receptor 7 agonist induces hypoplasia of the biliary system in a neonatal mouse model. J Microbiol Immunol Infect. 2018;51:166-173 pubmed publisher
    Viral infections and innate immunity signaling, especially Toll-like receptor 7 (TLR7) have been implicated in the pathogenesis of biliary atresia (BA)...
  49. Terhorst D, Chelbi R, Wohn C, Malosse C, Tamoutounour S, Jorquera A, et al. Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis. J Immunol. 2015;195:4953-61 pubmed publisher
    ..Previous studies showed that short-term, 5-7 d-long application of imiquimod (IMQ), a TLR7 agonist, to the skin of mice triggers a psoriasis-like inflammation...
  50. Chai H, Lim D, Suk J, Choi B, Cho Y. Design of anti-BVDV drug based on common chemical features, their interaction, and scaffolds of TLR8 agonists. Int J Biol Macromol. 2016;92:1095-1112 pubmed publisher
    ..features (pharmacophore) and to investigate the distinct restrictions affecting species-specificity on dual TLR7/TLR8 small agonists suggested in previous works...
  51. Zhang Q, Qian F, Yin X, Cao Q, Bai J, Du Q, et al. Associations of Toll-like receptor 7 and 8 Polymorphisms with Asthma and Asthma-related Phenotypes in a Chinese Han Population. Iran J Allergy Asthma Immunol. 2015;14:569-80 pubmed
    ..However, very little information about genetic association on TLR7/8 and asthma are available...
  52. Edwards A, Chen D, Fridley B, James K, Wu Y, Abecasis G, et al. Toll-like receptor polymorphisms and age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:1652-9 pubmed publisher
    ..Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0...
  53. Haderk F, Schulz R, Iskar M, Cid L, Worst T, Willmund K, et al. Tumor-derived exosomes modulate PD-L1 expression in monocytes. Sci Immunol. 2017;2: pubmed publisher
    ..These responses were abolished in Toll-like receptor 7 (TLR7)-deficient monocytes, suggesting exosomal hY4 as a driver of TLR7 signaling...
  54. Celhar T, Pereira Lopes S, Thornhill S, Lee H, Dhillon M, Poidinger M, et al. TLR7 and TLR9 ligands regulate antigen presentation by macrophages. Int Immunol. 2016;28:223-32 pubmed publisher
    ..We demonstrate that stimulation of all TLRs tested increases the phagocytosis of apoptotic cells by macrophages. TLR7 and TLR9 ligation decreased the levels of the surface co-expression molecules CD86 and MHCII, which was associated ..
  55. Li L, Cheng F, Wang F, Jia B, Luo X, Zhang S. The activation of TLR7 regulates the expression of VEGF, TIMP1, MMP2, IL-6, and IL-15 in Hela cells. Mol Cell Biochem. 2014;389:43-9 pubmed publisher
    ..Toll-like receptor 7 (TLR7), one of the TLRs binding with single-stranded RNA, activates intracellular pathways and stimulates the release of ..
  56. van Haren S, Ganapathi L, Bergelson I, Dowling D, Banks M, Samuels R, et al. In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. Cytokine. 2016;83:99-109 pubmed publisher
    ..lipid A (MPLA) and glucopyranosyl lipid Adjuvant aqueous formulation (GLA-AF), as well as agonists of TLR7/8 (R848) and TLR9 (CpG)...
  57. Schmid D, Park C, Hartl C, Subedi N, Cartwright A, Puerto R, et al. T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity. Nat Commun. 2017;8:1747 pubmed publisher
    ..This modular platform also enables PD-1-targeted delivery of a TLR7/8 agonist to the tumor microenvironment, increasing the proportion of tumor-infiltrating CD8+ T cells ..
  58. Giacomini E, Severa M, Rizzo F, Mechelli R, Annibali V, Ristori G, et al. IFN-? therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients. Eur J Immunol. 2013;43:1963-72 pubmed publisher
    ..IFN-? restored the frequency of TLR7-induced IgM and IgG-secreting cells in MS patients to the levels found in healthy donors, showing a specific ..
  59. Tomic J, White D, Shi Y, Mena J, Hammond C, He L, et al. Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity. J Immunol. 2006;176:3830-9 pubmed
    ..These findings suggest that TLR-7 "licenses" human B cells to respond to cytokines of the adaptive immune system (such as IL-2) and provide a strategy to increase the immunogenicity of lymphoma cells for therapeutic purposes. ..
  60. Valverde Villegas J, Dos Santos B, de Medeiros R, Mattevi V, Lazzaretti R, Sprinz E, et al. Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection - Differential influence in individuals with distinct ethnic background. Hum Immunol. 2017;78:221-226 pubmed publisher
    ..the genetic role of endosomal TLRs on susceptibility to HIV infection and HCV co-infection through the analysis of TLR7 rs179008, TLR8 rs3764880, TLR9 rs5743836 and TLR9 rs352140 polymorphisms in 789 Brazilian individuals (374 HIV+ and ..
  61. Buitendijk M, Eszterhas S, Howell A. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013;29:907-18 pubmed publisher
    ..These molecules include agonists for the Toll-like receptors (TLR), a family of innate immune receptors. TLR7 and 8, located in cellular endosomes, bind single-stranded RNA characteristic of viral genomes, and trigger ..
  62. Yan B, Zhang J, Zhang W, Wang M, Jia R, Zhu D, et al. GoTLR7 but not GoTLR21 mediated antiviral immune responses against low pathogenic H9N2 AIV and Newcastle disease virus infection. Immunol Lett. 2017;181:6-15 pubmed publisher
    ..Both TLR7 and TLR21 are important for the host antiviral immune response...
  63. Luo Z, Ge M, Chen J, Geng Q, Tian M, Qiao Z, et al. HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection. PLoS Pathog. 2017;13:e1006585 pubmed publisher
    ..This study reveals a novel mechanism underlying the regulation of TLR7 signaling during EV71 infection...
  64. Rostamian M, Niknam H. Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis in BALB/c mice. Mol Immunol. 2017;91:202-208 pubmed publisher
    ..In present study, we evaluated adjuvant effect of separate or combined use of a TLR7/8 agonist, R848 and a TLR4 agonist, monophosphoryl lipid A (MPL) beside soluble Leishmania antigen (SLA) in BALB/c ..
  65. Klymenko T, Gu Q, Herbert I, Stevenson A, Iliev V, Watkins G, et al. RNASeq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus type 16 infection, including loss of epithelial barrier function. J Virol. 2017;: pubmed publisher
    ..HPV infection repressed expression of the differentiated keratinocyte-specific pattern recognition receptor TLR7, the Langerhans cell chemoattractant, CCL20, and proinflammatory cytokines, IL1A and IL1B...
  66. Larson P, Kucaba T, Xiong Z, Olin M, Griffith T, Ferguson D. Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8. ACS Med Chem Lett. 2017;8:1148-1152 pubmed publisher
    ..Results are presented showing both TLR7/8 activations are highly correlated to N1-substitution, with TLR8 selectivity achieved through inclusion of an ..
  67. Hwang H, Min H, Kim D, Yu S, Jung S, Choi S, et al. Imiquimod induces a Toll-like receptor 7-independent increase in intracellular calcium via IP(3) receptor activation. Biochem Biophys Res Commun. 2014;450:875-9 pubmed publisher
    ..The pruritogenic effect of imiquimod is considered to be due to TLR7 activation; however that idea has been challenged by our studies showing intact pruritogenic effects of imiquimod ..
  68. Lin K, Lin T, Wang C, Liu H, Lin Y, Eng H. Down-regulation of Toll-like receptor 7 expression in hepatitis-virus-related human hepatocellular carcinoma. Hum Pathol. 2013;44:534-41 pubmed publisher
    ..the role of immune modulation in the pathogenesis of hepatocellular carcinoma (HCC), we studied the expression of TLR7 in cancerous and non-cancerous liver tissue from 87 patients with HCC...
  69. Gao D, Diao Y, Li W, Gao N, Liu Y, Wang Z, et al. Toll-like receptor 7 inactive ligands enhanced cytokine induction by conjugation to weak antigens. ChemMedChem. 2015;10:977-80 pubmed publisher
    ..These inactive analogues may be well suited as new adjuvants with superior activity after conjugation, effectively decreasing the side effects caused by conventional adjuvants. ..
  70. Qian F, Montgomery R. Quantitative imaging of lineage-specific Toll-like receptor-mediated signaling in monocytes and dendritic cells from small samples of human blood. J Vis Exp. 2012;: pubmed publisher
    ..Here we demonstrate the use of ImageStream in DCs to assess TLR7/8 activation-mediated increases in phosphorylation and nuclear translocation of a key transcription factor, NF-?B, ..