TLR10

Summary

Gene Symbol: TLR10
Description: toll like receptor 10
Alias: CD290, toll-like receptor 10
Species: human
Products:     TLR10

Top Publications

  1. Ma X, Liu Y, Gowen B, Graviss E, Clark A, Musser J. Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS ONE. 2007;2:e1318 pubmed
    ..Rare nonsynonymous polymorphisms in TLR6-TLR1-TLR10 were significantly overrepresented among African-American TB cases compared with ethnically-matched control ..
  2. Chen Y, Giovannucci E, Kraft P, Lazarus R, Hunter D. Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:1982-9 pubmed
    ..TLR6, TLR1, and TLR10 are also involved in the pathogen-mediated inflammation pathway...
  3. Mulla M, Myrtolli K, Tadesse S, Stanwood N, Gariepy A, Guller S, et al. Cutting-edge report: TLR10 plays a role in mediating bacterial peptidoglycan-induced trophoblast apoptosis. Am J Reprod Immunol. 2013;69:449-53 pubmed publisher
    ..This is dependent upon the presence of TLR1 and the absence of TLR6 and both TLR2 coreceptors. As TLR10 is also a TLR2 coreceptor, the objective of this study was to determine its expression and function in the ..
  4. Requena T, Gazquez I, Moreno A, Batuecas A, Aran I, Soto Varela A, et al. Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere's disease. Immunogenetics. 2013;65:345-55 pubmed publisher
    ..We genotyped SNV of TLR3, TRL7, TLR8 and TLR10 in 863 Spanish and 150 Italian patients with Meniere's disease (MD) and 1,013 controls by using Taqman assays...
  5. Kormann M, Depner M, Hartl D, Klopp N, Illig T, Adamski J, et al. Toll-like receptor heterodimer variants protect from childhood asthma. J Allergy Clin Immunol. 2008;122:86-92, 92.e1-8 pubmed publisher
    ..54; 95% CI, 0.37-0.81; P = .002), TLR6 (OR, 0.54; 95% CI, 0.37-0.79; P = .003), and TLR10 (OR, 0.58; 95% CI, 0.39-0.86; P = .006), all capable of forming heterodimers with TLR2...
  6. Govindaraj R, Manavalan B, Lee G, Choi S. Molecular modeling-based evaluation of hTLR10 and identification of potential ligands in Toll-like receptor signaling. PLoS ONE. 2010;5:e12713 pubmed publisher
    ..To improve our understanding of the TLR10 receptor-ligand interaction, we used homology modeling to construct a three dimensional (3D) structure of hTLR10 ..
  7. Purdue M, Lan Q, Wang S, Kricker A, Menashe I, Zheng T, et al. A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma. Carcinogenesis. 2009;30:275-81 pubmed publisher
    ..Thirty-six tag single-nucleotide polymorphisms (SNPs) in TLR2, TLR4 and the TLR10-TLR1-TLR6 gene cluster were genotyped...
  8. Georgel P, Macquin C, Bahram S. The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes. PLoS ONE. 2009;4:e7803 pubmed publisher
    ..Hence this work depicts a first overview of the diversity of almost all human TLR genes, a prelude for large-scale population genetics as well as genetic association studies. ..
  9. Chuang T, Ulevitch R. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta. 2001;1518:157-61 pubmed
    ..Human TLR10 contains 811 amino acid residues...

More Information

Publications113 found, 100 shown here

  1. Veltkamp M, van Moorsel C, Rijkers G, Ruven H, Grutters J. Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis. Tissue Antigens. 2012;79:25-32 pubmed publisher
    ..The aim of our study was to assess differences in genetic variation in the TLR10-TLR1-TLR6 gene cluster between patients and controls...
  2. Hasan U, Chaffois C, Gaillard C, Saulnier V, Merck E, Tancredi S, et al. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol. 2005;174:2942-50 pubmed
    Human TLR10 is an orphan member of the TLR family. Genomic studies indicate that TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2...
  3. Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol. 2002;168:4531-7 pubmed
    ..TLR1 and TLR6 were expressed in all cell types examined. TLR10 was highly expressed in B cells and weakly expressed in plasmacytoid dendritic cells (PDC)...
  4. Guan Y, Ranoa D, Jiang S, Mutha S, Li X, Baudry J, et al. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. J Immunol. 2010;184:5094-103 pubmed publisher
    ..Among human TLRs, TLR10 is the only family member without a defined agonist or function...
  5. Regan T, Nally K, Carmody R, Houston A, Shanahan F, Macsharry J, et al. Identification of TLR10 as a key mediator of the inflammatory response to Listeria monocytogenes in intestinal epithelial cells and macrophages. J Immunol. 2013;191:6084-92 pubmed publisher
    ..in the HT-29 IEC cell line and observed the most significant reduction in chemokine output following silencing of TLR10. This effect was also observed in the macrophage cell line THP-1...
  6. Lazarus R, Raby B, Lange C, Silverman E, Kwiatkowski D, Vercelli D, et al. TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med. 2004;170:594-600 pubmed
    TOLL-like receptor 10 (TLR10) is the most recently identified human homolog of the Drosophila TOLL protein...
  7. Sun J, Wiklund F, Zheng S, Chang B, Bälter K, Li L, et al. Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk. J Natl Cancer Inst. 2005;97:525-32 pubmed
    ..In this study, we investigated whether sequence variants in the TLR6-TLR1-TLR10 gene cluster, residing within a 54-kb region on 4p14, were associated with prostate cancer risk...
  8. Etem E, Elyas H, Ozgocmen S, Yıldırım A, Godekmerdan A. The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients. Rheumatol Int. 2011;31:1369-74 pubmed publisher
    ..This study was conducted to investigate the frequencies of TLR3 rs3775290, TLR9 rs187084, and TLR10 rs4129009 polymorphisms and to detect between polymorphisms and autoantibody positive as RF, collagen type II, ..
  9. Stevens V, Hsing A, Talbot J, Zheng S, Sun J, Chen J, et al. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. Int J Cancer. 2008;123:2644-50 pubmed publisher
    ..We investigated the role of common SNPs in a gene cluster encoding the TLR10, TLR6 and TLR1 proteins in prostate cancer etiology among 1,414 cancer cases and 1,414 matched controls from the ..
  10. Abad C, Gonzalez Escribano M, Diaz Gallo L, Lucena Soto J, Marquez J, Leo E, et al. Association of Toll-like receptor 10 and susceptibility to Crohn's disease independent of NOD2. Genes Immun. 2011;12:635-42 pubmed publisher
    ..The aim of this study was to investigate the possible role of the TLR10-TLR1-TLR6 gene cluster in CD susceptibility...
  11. Panigrahi M, Kumar A, Bhushan B, Ghosh S, Saravanan B, Sulabh S, et al. No change in mRNA expression of immune-related genes in peripheral blood mononuclear cells challenged with Theileria annulata in Murrah buffalo (Bubalus bubalis). Ticks Tick Borne Dis. 2016;7:754-758 pubmed publisher
    ..II, DQ alpha 1 (MHC-DQ?), signal-regulatory protein alpha (SIRPA), prion protein (PRNP), Toll-like receptor 10 (TLR10), c-musculoaponeurotic fibrosarcoma oncogene homolog (cMAF) and V-maf avian musculoaponeurotic fibrosarcoma ..
  12. Rajaraman P, Brenner A, Neta G, Pfeiffer R, Wang S, Yeager M, et al. Risk of meningioma and common variation in genes related to innate immunity. Cancer Epidemiol Biomarkers Prev. 2010;19:1356-61 pubmed publisher
    ..across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01...
  13. Tongtawee T, Bartpho T, Wattanawongdon W, Dechsukhum C, Leeanansaksiri W, Matrakool L, et al. Role of toll-like receptor 10 gene polymorphism and gastric mucosal pattern in patients with chronic gastritis. Turk J Gastroenterol. 2017;28:243-247 pubmed publisher
    ..We hypothesized that TLR10 rs10004195 polymorphism is associated with gastric mucosal patterns...
  14. Cabrera S, Sanchez E, Requena T, Martínez Bueno M, Benítez J, Perez N, et al. Intronic variants in the NFKB1 gene may influence hearing forecast in patients with unilateral sensorineural hearing loss in Meniere's disease. PLoS ONE. 2014;9:e112171 pubmed publisher
    ..NFKB1 and TNIP1, have been associated with two or more immune-mediated diseases and allelic variations in the TLR10 gene may influence bilateral affectation and clinical course in MD...
  15. Pandey G, Rizavi H, Bhaumik R, Ren X. Innate immunity in the postmortem brain of depressed and suicide subjects: Role of Toll-like receptors. Brain Behav Immun. 2019;75:101-111 pubmed publisher
    ..we have now determined the protein and mRNA expression of other TLRs (TLR1, TLR2, TLR5, TLR6, TLR7, TLR8, TLR9 and TLR10) in the PFC of DS, depressed non-suicide (DNS), non-depressed suicide (NDS) and NC subjects...
  16. Yoo I, Han J, Lee S, Jung W, Kim J, Kim Y, et al. Analysis of stage-specific expression of the toll-like receptor family in the porcine endometrium throughout the estrous cycle and pregnancy. Theriogenology. 2019;125:173-183 pubmed publisher
    ..Thus, we determined the expression of TLR1 - TLR10 and MYD88 in the endometrium, conceptus, and chorioallantoic tissues of pigs...
  17. Rao N, Nguyen S, Ngo K, Fung Leung W. A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol Cell Biol. 2005;25:6521-32 pubmed
  18. Koupenova M, Mick E, Mikhalev E, Benjamin E, Tanriverdi K, Freedman J. Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2015;35:1030-7 pubmed publisher
    ..In women, TLR1, TLR3, TLR6, and TLR7 were associated with body mass index and TLR5, TLR7, and TLR10 were associated with total cholesterol to high-density lipoprotein ratio...
  19. Zhang S, Liu W, Liu X, Qi J, Deng C. Biomarkers identification for acute myocardial infarction detection via weighted gene co-expression network analysis. Medicine (Baltimore). 2017;96:e8375 pubmed publisher
    ..of 428 DEGs in AMI were screened out, and the upregulated toll-like receptor (TLR) family genes (TLR1, TLR2, and TLR10) were enriched in wound response, immune response and inflammatory response functions, and downregulated genes (..
  20. Törmänen S, Korppi M, Lauhkonen E, Koponen P, Teräsjärvi J, Vuononvirta J, et al. Toll-like receptor 1 and 10 gene polymorphisms are linked to postbronchiolitis asthma in adolescence. Acta Paediatr. 2018;107:134-139 pubmed publisher
    ..and our previous studies found that TLR1 gene polymorphism was associated with postbronchiolitis asthma at one to six years of age, as was TLR10 at five to seven years of age. This study examined any associations at 11-13 years of age.
  21. Balachandran Y, Knaus S, Caldwell S, Singh B. Toll-like receptor 10 expression in chicken, cattle, pig, dog, and rat lungs. Vet Immunol Immunopathol. 2015;168:184-92 pubmed publisher
    ..b>TLR10 is identified as type 1 plasma membrane protein but the identity of its ligand remains unclear...
  22. Torices S, Julia A, Muñoz P, Varela I, Balsa A, Marsal S, et al. A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis. Arthritis Res Ther. 2016;18:221 pubmed
    Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is as yet unknown...
  23. Simone O, Bejarano M, Pierce S, Antonaci S, Wahlgren M, Troye Blomberg M, et al. TLRs innate immunereceptors and Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) CIDR1α-driven human polyclonal B-cell activation. Acta Trop. 2011;119:144-50 pubmed publisher
    ..the PfEMP1-CIDR1α B-cell interaction and demonstrate that PfEMP1-CIDR1α increases the expression of TLR7 and TLR10 mRNA transcripts and sensitizes B cells to TLR9 signalling via the MyD88 adaptor molecule...
  24. Lee S, Kok K, Jaume M, Cheung T, Yip T, Lai J, et al. Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. Proc Natl Acad Sci U S A. 2014;111:3793-8 pubmed publisher
    ..Among the 10 TLR family members identified in humans, TLR10 remains an orphan receptor without known agonist or function...
  25. Matas Cobos A, Redondo Cerezo E, Alegría Motte C, Martínez Chamorro A, Saenz López P, Jiménez P, et al. The role of Toll-like receptor polymorphisms in acute pancreatitis occurrence and severity. Pancreas. 2015;44:429-33 pubmed publisher
    ..TLR3 rs5743305, TLR4 rs4986790, TLR4 rs4986791, TLR5 rs5744174, TLR6 rs5743795, TLR7 rs2302267, TLR9 rs352140, and TLR10 rs4129009. No TLR polymorphism was related to AP incidence...
  26. Tang H, Cheng Z, Ma W, Liu Y, Tong Z, Sun R, et al. TLR10 and NFKBIA contributed to the risk of hip osteoarthritis: systematic evaluation based on Han Chinese population. Sci Rep. 2018;8:10243 pubmed publisher
    ..Our study aimed to investigate the associations of TLR10 and NFKBIA with respect to the HOA risk in Han Chinese individuals...
  27. Fonte E, Agathangelidis A, Reverberi D, Ntoufa S, Scarfò L, Ranghetti P, et al. Toll-like receptor stimulation in splenic marginal zone lymphoma can modulate cell signaling, activation and proliferation. Haematologica. 2015;100:1460-8 pubmed publisher
    ..Cells expressed significant levels of TLR1, TLR6, TLR7, TLR8, TLR9 and TLR10 mRNA; TLR2 and TLR4 showed a low, variable pattern of expression among patients whereas TLR3 and TLR5 mRNAs were ..
  28. Cipriano C, Maiti A, Hale G, Jiranek W. The host response: Toll-like receptor expression in periprosthetic tissues as a biomarker for deep joint infection. J Bone Joint Surg Am. 2014;96:1692-8 pubmed publisher
    ..005, p = 0.0003); the same was true of TLR6 (0.208 compared with 0.0165, p = 0.0059) but not of TLR10 (0.00019 compared with 0.00014, p = 0.6238). The AUC was 0.995 for TLR1, 0.883 for TLR6, and 0.546 for TLR10...
  29. Kaya M, Kose M, Guzeloglu A, Kıyma Z, Atli M. Early pregnancy-related changes in toll-like receptors expression in ovine trophoblasts and peripheral blood leukocytes. Theriogenology. 2017;93:40-45 pubmed publisher
    ..We detected mRNAs for TLR2, TLR4, TLR5, TLR6, TLR7, TLR8, and TLR10 but not for TLR1, TLR3, and TLR9 in trophoblasts...
  30. Boutens L, Mirea A, van den Munckhof I, Doppenberg Oosting M, Jaeger M, Hijmans A, et al. A role for TLR10 in obesity and adipose tissue morphology. Cytokine. 2018;108:205-212 pubmed publisher
    ..Recently, anti-inflammatory properties have been attributed to TLR10 in myeloid cells, the only member of the TLR family with inhibitory activity...
  31. Sivula J, Cordova Z, Tuimala J, Jaatinen T, Partanen J, Volin L, et al. Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation. Scand J Immunol. 2012;76:336-41 pubmed publisher
    ..We studied whether genetic variation in the TLR1, TLR2, TLR4, TLR5, TLR6 and TLR10 genes confers susceptibility to GvHD in 305 human leucocyte antigen-identical sibling donor HSCT's performed in a ..
  32. Dannemann M, Andres A, Kelso J. Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors. Am J Hum Genet. 2016;98:22-33 pubmed publisher
    ..Here we document a cluster of three Toll-like receptors (TLR6-TLR1-TLR10) in modern humans that carries three distinct archaic haplotypes, indicating repeated introgression from archaic ..
  33. Nishikawa R, Nagai H, Bito T, Ikeda T, Horikawa T, Adachi A, et al. Genetic prediction of the effectiveness of biologics for psoriasis treatment. J Dermatol. 2016;43:1273-1277 pubmed publisher
    ..Of these, rs11096957 on TLR10, which is associated with increased TNF-? production, was previously reported to be associated with treatment ..
  34. Törmänen S, Korppi M, Teräsjärvi J, Vuononvirta J, Koponen P, Helminen M, et al. Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis. Sci Rep. 2017;7:2956 pubmed publisher
    ..with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 genes. The gene polymorphisms were studied at the age of 6...
  35. Fang J, Chen L, Tang J, Hou S, Liao D, Ye Z, et al. Association Between Copy Number Variations of TLR7 and Ocular Behçet's Disease in a Chinese Han Population. Invest Ophthalmol Vis Sci. 2015;56:1517-23 pubmed publisher
    ..The frequencies of TLR gene copy number types (TLR1, TLR2, TLR3, TLR5, TLR6, TLR7, TLR9, TLR10) were compared among patients and controls by using the χ(2) test...
  36. Dewangan P, Panigrahi M, Kumar A, Saravanan B, Ghosh S, Asaf V, et al. The mRNA expression of immune-related genes in crossbred and Tharparkar cattle in response to in vitro infection with Theileria annulata. Mol Biol Rep. 2015;42:1247-55 pubmed publisher
    ..qPCR was employed to measure relative mRNA expression of toll-like receptor 10 (TLR10), signal-regulatory protein alpha (SIRPA), MHC class II DQα (BoLA-DQA), musculoaponeurotic fibrosarcoma (MAF) ..
  37. Lauhkonen E, Koponen P, Vuononvirta J, Teräsjärvi J, Nuolivirta K, Toikka J, et al. Gene Polymorphism of Toll-Like Receptors and Lung Function at Five to Seven Years of Age after Infant Bronchiolitis. PLoS ONE. 2016;11:e0146526 pubmed publisher
    ..Data on single nucleotide polymorphisms (SNP) of TLR1 rs5743618, TLR2 rs5743708, TLR6 rs5743810 and TLR10 rs4129009 (TLR2 subfamily) and TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992 and TLR 9 rs187084 ..
  38. Lin T, Su H, Kang H, Chang T. The Interactive Roles of Lipopolysaccharides and dsRNA/Viruses on Respiratory Epithelial Cells and Dendritic Cells in Allergic Respiratory Disorders: The Hygiene Hypothesis. Int J Mol Sci. 2017;18: pubmed publisher
    ..In humans, TLRs consist of TLR1 to TLR10. They regulate cellular responses through engagement with TLR ligands, e.g...
  39. Smith L, Weissenburger Moser L, Heires A, Bailey K, Romberger D, LeVan T. Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response. Genes Immun. 2017;18:67-74 pubmed publisher
    ..determine whether responsiveness to organic dust among agricultural workers was dependent on polymorphisms in the TLR10-TLR1-TLR6 gene cluster...
  40. Xu T, Wang Y, Li J, Shu C, Han J, Chu Q. Comparative genomic evidence for duplication of TLR1 subfamily and miiuy croaker TLR1 perceives LPS stimulation via MyD88 and TIRAP. Fish Shellfish Immunol. 2016;56:336-348 pubmed publisher
    ..This paper reports the evolutionary spectrum of the TLR1 subfamily (referred to as TLR1, TLR6, and TLR10) as determined using the comparative genomic approach...
  41. Moskvina V, Smith M, Ivanov D, Blackwood D, Stclair D, Hultman C, et al. Genetic differences between five European populations. Hum Hered. 2010;70:141-9 pubmed publisher
    ..IRF4), the LCT gene, genes involved in NAD metabolism, and in immunity (HLA and the Toll-like receptor genes TLR10, TLR1, TLR6)...
  42. Lien E, Ingalls R. Toll-like receptors. Crit Care Med. 2002;30:S1-11 pubmed
    ..Signals initiated by the interaction of TLRs with specific microbial patterns direct the subsequent inflammatory response. Thus, TLR signaling represents a key component of the innate immune response to microbial infection. ..
  43. Stark J, Wiklund F, Gronberg H, Schumacher F, Sinnott J, Stampfer M, et al. Toll-like receptor signaling pathway variants and prostate cancer mortality. Cancer Epidemiol Biomarkers Prev. 2009;18:1859-63 pubmed publisher
    ..No significant associations were observed for common haplotypes and PCa mortality. This study highlights the importance of studies of PCa mortality because risk factors for incidence and mortality may differ. ..
  44. Nemati M, Larussa T, Khorramdelazad H, Mahmoodi M, Jafarzadeh A. Toll-like receptor 2: An important immunomodulatory molecule during Helicobacter pylori infection. Life Sci. 2017;178:17-29 pubmed publisher
    ..broad of microbial components due to its potential to form heterodimers with other TLRs, including TLR1, TLR6 and TLR10. A number of H...
  45. Nuolivirta K, Törmänen S, Teräsjärvi J, Vuononvirta J, Koponen P, Korppi M, et al. Post-bronchiolitis wheezing is associated with toll-like receptor 9 rs187084 gene polymorphism. Sci Rep. 2016;6:31165 pubmed publisher
    ..study was to evaluate whether there are associations between TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and viral findings, clinical characteristics or subsequent wheezing in infants with ..
  46. Nyúl Tóth Ã, Kozma M, NagyÅ‘szi P, Nagy K, Fazakas C, Haskó J, et al. Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes. Brain Behav Immun. 2017;64:220-231 pubmed publisher
    ..Among the ten known human TLRs, TLR2, TLR4, TLR5, TLR6 and TLR10 were found to be expressed...
  47. Sousa K, Ribeiro A, Dantas W, Oliveira L, Gasparino E, Guimarães S. Comparison of gene expression of Toll-like receptors and cytokines between Piau and Commercial line (Landrace×Large White crossbred) pigs vaccinated against Pasteurella multocida type D. Res Vet Sci. 2017;114:273-280 pubmed publisher
    ..For gene expression in BALF, vaccinated Commercial pigs showed higher expression of TLR6, TLR10, IL6, IL8, IL10, TNFα and TGFβ genes than vaccinated Piau pigs...
  48. Nagashima H, Iwatani S, Cruz M, Jiménez Abreu J, Uchida T, Mahachai V, et al. Toll-like Receptor 10 in Helicobacter pylori Infection. J Infect Dis. 2015;212:1666-76 pubmed publisher
    ..Microarray analysis of gastric biopsy specimens from H. pylori-positive and uninfected subjects showed that TLR10 messenger RNA (mRNA) levels were upregulated approximately 15-fold in infected subjects; these findings were ..
  49. Deschamps M, Laval G, Fagny M, Itan Y, Abel L, Casanova J, et al. Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes. Am J Hum Genet. 2016;98:5-21 pubmed publisher
    ..Notably, among the genes presenting the highest Neandertal ancestry, we find the TLR6-TLR1-TLR10 cluster, which also contains functional adaptive variation in Europeans...
  50. Morgan A, Lam W, Han D, Fraser A, Ferguson L. Genetic variation within TLR10 is associated with Crohn's disease in a New Zealand population. Hum Immunol. 2012;73:416-20 pubmed publisher
    ..Recently the first association of TLR10 with Crohn's disease (CD) was reported...
  51. Xiao W, Liu Z, Lin J, Li J, Wu K, Ma Y, et al. Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease. Autoimmunity. 2015;48:13-8 pubmed publisher
    ..The aim of this study was to evaluate the potential association of polymorphisms in TLR1, TLR6 and TLR10 genes with GD in Chinese Cantonese population. Seven single nucleotide polymorphisms (i.e...
  52. de Barros Gallo C, Marichalar Mendia X, Setien Olarra A, Acha Sagredo A, Bediaga N, Gainza Cirauqui M, et al. Toll-like receptor 2 rs4696480 polymorphism and risk of oral cancer and oral potentially malignant disorder. Arch Oral Biol. 2017;82:109-114 pubmed publisher
    ..Genetic polymorphisms in TLR1, TLR2, TLR4, TLR6, TLR9, and TLR10 were genotyped by TaqMan® assays or pyrosequencing...
  53. Atli M, Kose M, Hitit M, Kaya M, Bozkaya F. Expression patterns of Toll-like receptors in the ovine corpus luteum during the early pregnancy and prostaglandin F2?-induced luteolysis. Theriogenology. 2018;111:25-33 pubmed publisher
    ..polymerase chain reaction (qPCR) was used to evaluate the expression profiles of TLR2, TLR4, TLR6, TLR8, and TLR10, while free-floating in situ hybridization and immunohistochemistry were used to define the spatial localization ..
  54. Henmyr V, Carlberg D, Manderstedt E, Lind Halldén C, Sall T, Cardell L, et al. Genetic variation of the Toll-like receptors in a Swedish allergic rhinitis case population. BMC Med Genet. 2017;18:18 pubmed publisher
    ..The overall level of genetic variation was clearly different among the 10 TLR genes. The TLR10-TLR1-TLR6 locus was the most variable, while the TLR7-TLR8 locus was consistently showing a much lower level of ..
  55. Osvaldova A, Stepanova H, Faldyna M, Matiasovic J. Gene expression values of pattern-recognition receptors in porcine leukocytes and their response to Salmonella enterica serovar Typhimurium infection. Res Vet Sci. 2017;114:31-35 pubmed publisher
    ..The B cells expressed high levels of TLR1, TLR6, TLR9, TLR10, and RP-105...
  56. Ho M, Ingle J, Bongartz T, Kalari K, Goss P, Shepherd L, et al. TCL1A Single-Nucleotide Polymorphisms and Estrogen-Mediated Toll-Like Receptor-MYD88-Dependent Nuclear Factor-?B Activation: Single-Nucleotide Polymorphism- and Selective Estrogen Receptor Modulator-Dependent Modification of Inflammation and Immune R. Mol Pharmacol. 2017;92:175-184 pubmed publisher
    ..We found that TLR2, TLR7, TLR9, and TLR10 expression, as well as that of MYD88, could be modulated by TCL1A in a SNP and estrogen-dependent fashion ..
  57. Mazzucchelli I, Lisini D, Garofoli F, Dragoni S, Angelini M, Pozzi M, et al. Expression and function of toll-like receptors in human circulating endothelial colony forming cells. Immunol Lett. 2015;168:98-104 pubmed publisher
    ..in vitro umbilical cord blood (UCB) and adult peripheral blood (PB) ECFCs and studied the expression of TLR1 to TLR10 mRNA by qPCR analysis, and we further characterized TLR function in ECFCs through functional assays including in ..
  58. Kuang L, Deng Y, Liu X, Zou Z, Mi L. Effects of a traditional Chinese medicine, Longdanxiegan formula granule, on Toll-like receptor pathway in female guinea pigs with recurrent genital herpes. Taiwan J Obstet Gynecol. 2016;55:220-8 pubmed publisher
    ..TLR1, TLR4, TLR6, TLR7, TLR8, TLR9, and TLR10 showed a significant decrease while, TLR2, TLR3, and TLR5 increased in genital herpes and recurrent genital herpes ..
  59. Latorre E, Pradilla A, Chueca B, Pagan R, Layunta E, Alcalde A, et al. Listeria monocytogenes Inhibits Serotonin Transporter in Human Intestinal Caco-2 Cells. Microb Ecol. 2016;72:730-9 pubmed publisher
    ..The results also demonstrate that L. monocytogenes yields TLR2 and TLR10 transcriptional changes in intestinal epithelial cells and suggest that TLR10 is potentially involved in the ..
  60. Ishengoma E, Agaba M. Evolution of toll-like receptors in the context of terrestrial ungulates and cetaceans diversification. BMC Evol Biol. 2017;17:54 pubmed publisher
    ..of nucleotide and protein sequence diversity in seven Toll-like receptors (TLR2, TLR3, TLR4, TLR5, TLR7, TLR9 and TLR10) between giraffe and closely related species was determined...
  61. Cho W, Jang J, Choi E, Jeon Y, Jung I, Kim S, et al. Association of Toll-like receptor 10 polymorphisms with autoimmune thyroid disease in Korean children. Thyroid. 2015;25:250-5 pubmed publisher
    ..We investigated three polymorphisms in the TLR10 gene (rs4129009, rs11096956, and rs10004195) in 85 Korean AITD patients (Graves' disease, [GD]=50, Hashimoto's ..
  62. Kadowaki N, Ho S, Antonenko S, Malefyt R, Kastelein R, Bazan F, et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med. 2001;194:863-9 pubmed
  63. Sung H, Camargo M, Yu K, Weinstein S, Morgan D, Albanes D, et al. Association of 4p14 TLR locus with antibodies to Helicobacter pylori. Genes Immun. 2015;16:567-70 pubmed publisher
    ..Our findings suggest that 4p14 polymorphisms are linked to host immune response to H. pylori infection but not to its acquisition. ..
  64. Kastelijn E, van Moorsel C, Rijkers G, Ruven H, Karthaus V, Kwakkel van Erp J, et al. Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation. J Heart Lung Transplant. 2010;29:665-71 pubmed publisher
    ..We hypothesized that polymorphisms in 10 genes coding for TLR1 to TLR10 might contribute to an altered immune response and the subsequent development of BOS...
  65. Mayerle J, den Hoed C, Schurmann C, Stolk L, Homuth G, Peters M, et al. Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA. 2013;309:1912-20 pubmed publisher
    ..pylori seroprevalence, a finding that requires replication in nonwhite populations. If confirmed, genetic variations in TLR1 may help explain some of the observed variation in individual risk for H. pylori infection. ..
  66. Hess N, Jiang S, Li X, Guan Y, Tapping R. TLR10 Is a B Cell Intrinsic Suppressor of Adaptive Immune Responses. J Immunol. 2017;198:699-707 pubmed publisher
    ..Despite thousands of publications on TLRs, the function of TLR10 remains unknown...
  67. Zhou X, Jia W, Shen G, Qin H, Yu X, Chen L, et al. Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk. Cancer Epidemiol Biomarkers Prev. 2006;15:862-6 pubmed
    ..To test the association between NPC and variants in Toll-like receptor 10 (TLR10), we conducted a hospital-based case-control study in a Cantonese-speaking population in Guangdong province...
  68. Enevold C, Oturai A, Sørensen P, Ryder L, Koch Henriksen N, Bendtzen K. Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients. Mult Scler. 2010;16:942-9 pubmed publisher
    ..The rs5743810 polymorphism of TLR6 may be involved in development of anti-interferon-beta antibodies in males, although further studies are required to firmly establish this. ..
  69. Guirado M, Gil H, Saenz Lopez P, Reinboth J, Garrido F, Cozar J, et al. Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer. Hum Immunol. 2012;73:668-72 pubmed publisher
    ..We studied the possible association of polymorphisms in genes encoding NOD2, RIPK2, TLR10 and C13ORF31 with the risk, clinical/pathological characteristics and outcomes of urothelial cancer...
  70. Brown V, Brown R, Ozinsky A, Hesselberth J, Fields S. Binding specificity of Toll-like receptor cytoplasmic domains. Eur J Immunol. 2006;36:742-53 pubmed
    ..In summary, interactions between the TLR, MyD88, and novel associated proteins have been characterized. ..
  71. Smith N, Hankinson J, Simpson A, Denning D, Bowyer P. Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT. Clin Microbiol Infect. 2014;20:O960-8 pubmed publisher
    ..Macrophages from CCPA patients showed low TLR3 and TLR10 expression and high TREM1 expression at baseline, as compared with macrophages from healthy subjects, with major ..
  72. Oosting M, Cheng S, Bolscher J, Vestering Stenger R, Plantinga T, Verschueren I, et al. Human TLR10 is an anti-inflammatory pattern-recognition receptor. Proc Natl Acad Sci U S A. 2014;111:E4478-84 pubmed publisher
    ..We demonstrate that TLR10 is a modulatory receptor with mainly inhibitory effects...
  73. Liu S, Zhang C, Zhou W, Chen M, Lin L. [Expression of toll-like receptors in human epidermal keratinocytes]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008;30:296-300 pubmed
    ..Human epidermal keratinocytes constitutively express all TLR 1-10 mRNA, which may enable human keratinocytes to respond to a wide range of pathogenic micro-organisms. ..
  74. Gimalova G, Karunas A, Fedorova I, Gumennaia Ã, Levasheva S, Khismatullina Z, et al. [Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan]. Mol Biol (Mosk). 2014;48:265-76 pubmed
    ..In this study polymorphic variants of PRR genes--Toll-like receptors (TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TLR10), NOD-like receptors (NOD1, NOD2), lipopolysaccharide receptor CD14 gene, and C11orf30 and LRRC32 genes, located ..
  75. Qian F, Zhang Q, Zhou L, Jin G, Bai J, Yin K. Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population. J Investig Allergol Clin Immunol. 2010;20:340-6 pubmed
    ..49; 95% CI, 0.26-0.95; P = .046). Our results indicate that a genetic variant in the TLR2 subfamily may play a role in susceptibility to asthma. ..
  76. Jiang S, Li X, Hess N, Guan Y, Tapping R. TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling. J Immunol. 2016;196:3834-41 pubmed publisher
    ..Among the 10-member human TLR family, TLR10 is the only remaining orphan receptor without a known ligand or signaling function...
  77. Mohammed I, Abedin A, Tsintzas K, Abedin S, Otri A, Hopkinson A, et al. Increased expression of hepcidin and toll-like receptors 8 and 10 in viral keratitis. Cornea. 2011;30:899-904 pubmed publisher
    ..LEAP-2 may have a role in dry eye. Further studies will help to improve the understanding of these diseases and yield novel therapeutic interventions. ..
  78. Bulat Kardum L, Etokebe G, Lederer P, Balen S, Dembic Z. Genetic Polymorphisms in the Toll-like Receptor 10, Interleukin (IL)17A and IL17F Genes Differently Affect the Risk for Tuberculosis in Croatian Population. Scand J Immunol. 2015;82:63-9 pubmed publisher
    ..We have now extended our survey and found that single nucleotide polymorphism (SNP) in TLR10 (rs11096957) is associated with risk for TB...
  79. Sabah Ozcan S, Baser A, Olcucu T, Baris I, Elmas L, Tuncay L, et al. Human TLR gene family members are differentially expressed in patients with urothelial carcinoma of the bladder. Urol Oncol. 2017;35:674.e11-674.e17 pubmed publisher
    ..TLR2-7 and TLR10 expressions were significantly higher in UC than in the control group (P<0.05 for all comparisons)...
  80. Strauss J, Romero R, Gomez Lopez N, Haymond Thornburg H, Modi B, Teves M, et al. Spontaneous preterm birth: advances toward the discovery of genetic predisposition. Am J Obstet Gynecol. 2018;218:294-314.e2 pubmed publisher
    ..in the negative regulation (dampening) of the innate immune response (eg, CARD6, CARD8, NLRP10, NLRP12, NOD2, TLR10) and antimicrobial peptide/proteins (eg, DEFB1, MBL2)...
  81. Mailaparambil B, Krueger M, Heinze J, Forster J, Heinzmann A. Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases. Dis Markers. 2008;25:59-65 pubmed
    ..013). In addition, association was found with TLR10 haplotypes (p = 0.024)...
  82. Tewfik M, Bosse Y, Lemire M, Hudson T, Vallée Smejda S, Al Shemari H, et al. Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE. Allergy. 2009;64:746-53 pubmed publisher
    ..IRAK4 may be important in the regulation of IgE levels in patients with inflammatory diseases of the airways. ..
  83. Stappers M, Oosting M, Ioana M, Reimnitz P, Mouton J, Netea M, et al. Genetic Variation in TLR10, an Inhibitory Toll-Like Receptor, Influences Susceptibility to Complicated Skin and Skin Structure Infections. J Infect Dis. 2015;212:1491-9 pubmed publisher
    ..play a central role in the innate immune response to complicated skin and skin structure infections (cSSSIs), with TLR10 being the first family member known to have an inhibitory function...
  84. Mikacenic C, Reiner A, Holden T, Nickerson D, Wurfel M. Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses. Genes Immun. 2013;14:52-7 pubmed publisher
    ..We identified a very strong association (P<1 × 10(-27)) between genetic variation within the TLR10/1/6 locus on chromosome 4, and Pam(3)CSK(4)-induced cytokine responses...
  85. Sindhu S, Akhter N, Kochumon S, Thomas R, Wilson A, Shenouda S, et al. Increased Expression of the Innate Immune Receptor TLR10 in Obesity and Type-2 Diabetes: Association with ROS-Mediated Oxidative Stress. Cell Physiol Biochem. 2018;45:572-590 pubmed publisher
    ..receptors (TLR) such as TLR2 and TLR4 have emerged as key players in metabolic inflammation; nonetheless, TLR10 expression in the adipose tissue and its significance in obesity/T2D remain unclear...
  86. Kollewe C, Mackensen A, Neumann D, Knop J, Cao P, Li S, et al. Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. J Biol Chem. 2004;279:5227-36 pubmed
    ..Thus, IRAK-1 regulates its own availability as an adapter molecule by sequential autophosphorylation. ..
  87. Kim S, Park H, Hong I, Chung J, Eun Y. A missense polymorphism (rs11466653, Met326Thr) of toll-like receptor 10 (TLR10) is associated with tumor size of papillary thyroid carcinoma in the Korean population. Endocrine. 2013;43:161-9 pubmed publisher
    ..The aim of this study was to investigate whether TLR gene cluster (TLR10-TLR1-TLR6) polymorphisms are associated with the etiology of papillary thyroid carcinoma (PTC) and its ..
  88. Ammerdorffer A, Stappers M, Oosting M, Schoffelen T, Hagenaars J, Bleeker Rovers C, et al. Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro. Cytokine. 2016;77:196-202 pubmed publisher
    Coxiella burnetii, the causative agent of Q fever, is recognized by TLR2. TLR10 can act as an inhibitory receptor on TLR2-derived immune responses. Therefore, we investigated the role of TLR10 on C...
  89. Ravishankar Ram M, Goh K, Leow A, Poh B, Loke M, Harrison R, et al. Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection. PLoS ONE. 2015;10:e0141865 pubmed publisher
    ..pylori in a genotype-independent manner. We concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease.
  90. Hess N, Felicelli C, Grage J, Tapping R. TLR10 suppresses the activation and differentiation of monocytes with effects on DC-mediated adaptive immune responses. J Leukoc Biol. 2017;101:1245-1252 pubmed publisher
    ..b>TLR10 is the only TLR family member without a known ligand, signaling pathway, or clear cellular function...
  91. Heinzmann A, Mailaparambil B, Mingirulli N, Krueger M. Association of interleukin-13/-4 and toll-like receptor 10 with preterm births. Neonatology. 2009;96:175-81 pubmed publisher
    ..IL-13/IL-4 and TLR-10 might be involved in the genetics of PTB. The dissection of the genetic background may provide a deeper understanding of the pathophysiology of PTB and help to identify new drug targets for its prevention. ..
  92. Zhou L, Wei B, Xing C, Xie H, Yu X, Wu L, et al. Polymorphism in 3'-untranslated region of toll-like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation. Transpl Infect Dis. 2011;13:250-8 pubmed publisher
    ..390, 95% confidence interval 0.159-0.957). Our findings indicate that polymorphism in 3'-untranslated regions of the TLR4 gene may be related to protection from HBV recurrence after liver transplantation in Han Chinese patients. ..