TLR1

Summary

Gene Symbol: TLR1
Description: toll like receptor 1
Alias: CD281, TIL, TIL. LPRS5, rsc786, toll-like receptor 1, toll/interleukin-1 receptor-like protein
Species: human
Products:     TLR1

Top Publications

  1. Hawn T, Misch E, Dunstan S, Thwaites G, Lan N, Quy H, et al. A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol. 2007;37:2280-9 pubmed
    ..Lipopeptides are present in a wide variety of microbes and stimulate immune responses through TLR1/2 or TLR2/6 heterodimers...
  2. Wurfel M, Gordon A, Holden T, Radella F, Strout J, Kajikawa O, et al. Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med. 2008;178:710-20 pubmed publisher
    ..The SNP demonstrating the most hypermorphic effect was the G allele of TLR1(-7202A/G) (rs5743551), which associated with elevated TLR1-mediated cytokine production (P < 2 x 10(-20))...
  3. Gautam J, Ashish -, Comeau L, Krueger J, Smith M. Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling. J Biol Chem. 2006;281:30132-42 pubmed
    ..In Region I, residues Arg-748 and Phe-749 in TLR2 DD loop were involved in close contacts with Gly-676 in the TLR1 BB loop...
  4. Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen R, et al. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 2002;8:878-84 pubmed
    ..After OspA immunization, mice genetically deficient in either TLR2 (TLR2(-/-)) or TLR1 (TLR1(-/-)) produced low titers of antibodies against OspA...
  5. Hawn T, Scholes D, Li S, Wang H, Yang Y, Roberts P, et al. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS ONE. 2009;4:e5990 pubmed publisher
    ..53 (0.29-0.96)). These results provide the first evidence of associations of TLR5 and TLR1 variants with altered risks of acquiring rUTI and pyelonephritis, respectively...
  6. Uciechowski P, Imhoff H, Lange C, Meyer C, Browne E, Kirsten D, et al. Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression. J Leukoc Biol. 2011;90:377-88 pubmed publisher
    Human TLR1 plays an important role in host defense against Mycobacterium tuberculosis. Our aim was to analyze the association of the loss of TLR1 surface expression and TLR1 SNPs with susceptibility to TB...
  7. Guan Y, Ranoa D, Jiang S, Mutha S, Li X, Baudry J, et al. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. J Immunol. 2010;184:5094-103 pubmed publisher
    ..Phylogenetic analysis reveals that TLR10 is most related to TLR1 and TLR6, both of which mediate immune responses to a variety of microbial and fungal components in cooperation ..
  8. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002;169:10-4 pubmed
    ..TLR6 associates with TLR2 and recognizes diacylated mycoplasmal lipopeptide along with TLR2. We report here that TLR1 associates with TLR2 and recognizes the native mycobacterial 19-kDa lipoprotein along with TLR2...
  9. Hamann L, Bedu Addo G, Eggelte T, Schumann R, Mockenhaupt F. The toll-like receptor 1 variant S248N influences placental malaria. Infect Genet Evol. 2010;10:785-9 pubmed publisher
    ..These data support that TLR-1 is involved in the recognition of P. falciparum and indicate its role in susceptibility to and manifestation of malaria in pregnancy. ..

More Information

Publications81

  1. Johnson C, Lyle E, Omueti K, Stepensky V, Yegin O, Alpsoy E, et al. Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol. 2007;178:7520-4 pubmed
    ..In this role, TLR1 enables host responses to a variety of bacteria, including pathogenic species of mycobacteria...
  2. Hasan U, Chaffois C, Gaillard C, Saulnier V, Merck E, Tancredi S, et al. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol. 2005;174:2942-50 pubmed
    ..Genomic studies indicate that TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2...
  3. Randow F, Seed B. Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability. Nat Cell Biol. 2001;3:891-6 pubmed
    ..Toll-like receptors are retained intracellularly in the absence of gp96, explaining the unresponsiveness of the mutant to microbial stimuli. ..
  4. Stevens V, Hsing A, Talbot J, Zheng S, Sun J, Chen J, et al. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. Int J Cancer. 2008;123:2644-50 pubmed publisher
    ..We investigated the role of common SNPs in a gene cluster encoding the TLR10, TLR6 and TLR1 proteins in prostate cancer etiology among 1,414 cancer cases and 1,414 matched controls from the Cancer Prevention ..
  5. Marques C, Brito de Souza V, Guerreiro L, Martins J, Amaral E, Cardoso C, et al. Toll-like receptor 1 N248S single-nucleotide polymorphism is associated with leprosy risk and regulates immune activation during mycobacterial infection. J Infect Dis. 2013;208:120-9 pubmed publisher
    Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported...
  6. Plantinga T, Johnson M, Scott W, van de Vosse E, Velez Edwards D, Smith P, et al. Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J Infect Dis. 2012;205:934-43 pubmed publisher
    ..Analyses of TLR SNPs revealed that 3 TLR1 SNPs (R80T, S248N, I602S) were significantly associated with candidemia susceptibility in whites...
  7. Ocejo Vinyals J, Puente de Mateo E, Ausín F, Aguero R, Arroyo J, Gutiérrez Cuadra M, et al. Human toll-like receptor 1 T1805G polymorphism and susceptibility to pulmonary tuberculosis in northern Spain. Int J Tuberc Lung Dis. 2013;17:652-4 pubmed publisher
    ..T1805G, a functional TLR1 single nucleotide polymorphism (SNP), has been associated with susceptibility to pulmonary tuberculosis (PTB), but ..
  8. Sandor F, Latz E, Re F, Mandell L, Repik G, Golenbock D, et al. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol. 2003;162:1099-110 pubmed
    ..This paper demonstrates that TLR1 and TLR2 are required for ara-lipoarabinomannan- and tripalmitoyl cysteinyl lipopeptide-stimulated cytokine ..
  9. Wong S, Gochhait S, Malhotra D, Pettersson F, Teo Y, Khor C, et al. Leprosy and the adaptation of human toll-like receptor 1. PLoS Pathog. 2010;6:e1000979 pubmed publisher
    ..different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0...
  10. Pierik M, Joossens S, Van Steen K, Van Schuerbeek N, Vlietinck R, Rutgeerts P, et al. Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. Inflamm Bowel Dis. 2006;12:1-8 pubmed
    ..Thirty-five single nucleotide polymorphisms (SNP) in TLR1-10 were identified from public databases...
  11. Purdue M, Lan Q, Wang S, Kricker A, Menashe I, Zheng T, et al. A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma. Carcinogenesis. 2009;30:275-81 pubmed publisher
    ..Thirty-six tag single-nucleotide polymorphisms (SNPs) in TLR2, TLR4 and the TLR10-TLR1-TLR6 gene cluster were genotyped...
  12. Velez D, Wejse C, Stryjewski M, Abbate E, Hulme W, Myers J, et al. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum Genet. 2010;127:65-73 pubmed publisher
    ..In the present study, 71 polymorphisms in TLR1, TLR2, TLR4, TLR6, and TLR9 were examined from 474 (295 cases and 179 controls) African-Americans, 381 (237 cases ..
  13. Misch E, Macdonald M, Ranjit C, Sapkota B, Wells R, Siddiqui M, et al. Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis. 2008;2:e231 pubmed publisher
    ..regulators of the innate immune response to pathogens, including Mycobacterium leprae, which is recognized by TLR1/2 heterodimers...
  14. Omueti K, Mazur D, Thompson K, Lyle E, Tapping R. The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components. J Immunol. 2007;178:6387-94 pubmed
    As a pattern recognition receptor, TLR1 mediates innate immune responses to a variety of microbial cell wall components including bacterial lipoproteins...
  15. Kesh S, Mensah N, Peterlongo P, Jaffe D, Hsu K, van den Brink M, et al. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann N Y Acad Sci. 2005;1062:95-103 pubmed
    ..In this preliminary study, we examined the association between single nucleotide polymorphisms (SNPs) in TLR1, TLR4, and TLR6 genes and development of invasive aspergillosis (IA) in 127 allogeneic hematopoietic stem cell ..
  16. Randhawa A, Shey M, Keyser A, Peixoto B, Wells R, de Kock M, et al. Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants. PLoS Pathog. 2011;7:e1002174 pubmed publisher
    ..After stimulation with TLR1/6 lipopeptide ligands, PBMCs from TLR1/6-deficient individuals (stratified by TLR1_T1805G and TLR6_C745T ..
  17. Georgel P, Macquin C, Bahram S. The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes. PLoS ONE. 2009;4:e7803 pubmed publisher
    ..alleles: 7/protein alleles: 3), 4 (4/3), 7 (6/3), 8 (9/2) and 9 (8/3) being comparatively least diverse whereas TLR1 (11/10), 5 (14/12), 6 (10/8) and 10 (15/10) show a substantial number of alleles...
  18. Kang J, Nan X, Jin M, Youn S, Ryu Y, Mah S, et al. Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity. 2009;31:873-84 pubmed publisher
    ..Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6...
  19. Kormann M, Depner M, Hartl D, Klopp N, Illig T, Adamski J, et al. Toll-like receptor heterodimer variants protect from childhood asthma. J Allergy Clin Immunol. 2008;122:86-92, 92.e1-8 pubmed publisher
    ..Protective effects on atopic asthma were identified for single nucleotide polymorphisms in TLR1 (odds ratio [OR], 0.54; 95% CI, 0.37-0.81; P = .002), TLR6 (OR, 0.54; 95% CI, 0.37-0.79; P = ...
  20. Veltkamp M, van Moorsel C, Rijkers G, Ruven H, Grutters J. Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis. Tissue Antigens. 2012;79:25-32 pubmed publisher
    ..The aim of our study was to assess differences in genetic variation in the TLR10-TLR1-TLR6 gene cluster between patients and controls...
  21. Ma X, Liu Y, Gowen B, Graviss E, Clark A, Musser J. Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS ONE. 2007;2:e1318 pubmed
    ..Rare nonsynonymous polymorphisms in TLR6-TLR1-TLR10 were significantly overrepresented among African-American TB cases compared with ethnically-matched control ..
  22. Karoly E, Fekete A, Banki N, Szebeni B, Vannay A, Szabo A, et al. Heat shock protein 72 (HSPA1B) gene polymorphism and Toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children. Pediatr Res. 2007;61:371-4 pubmed
  23. Schröder N, Diterich I, Zinke A, Eckert J, Draing C, von Baehr V, et al. Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. J Immunol. 2005;175:2534-40 pubmed
    ..3 vs 12.5%, odds ratio 0.163, 95% confidence interval 0.04-0.76, p = 0.018). These data suggest that Arg753Gln may protect from the development of late stage LD due to a reduced signaling via TLR-2/TLR-1. ..
  24. Ozinsky A, Underhill D, Fontenot J, Hajjar A, Smith K, Wilson C, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A. 2000;97:13766-71 pubmed
    ..We show that the cytoplasmic domain of TLR2 can form functional pairs with TLR6 or TLR1, and this interaction leads to cytokine induction...
  25. Chen Y, Giovannucci E, Kraft P, Lazarus R, Hunter D. Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:1982-9 pubmed
    ..TLR6, TLR1, and TLR10 are also involved in the pathogen-mediated inflammation pathway...
  26. Sun J, Wiklund F, Zheng S, Chang B, Bälter K, Li L, et al. Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk. J Natl Cancer Inst. 2005;97:525-32 pubmed
    ..In this study, we investigated whether sequence variants in the TLR6-TLR1-TLR10 gene cluster, residing within a 54-kb region on 4p14, were associated with prostate cancer risk...
  27. Rock F, Hardiman G, Timans J, Kastelein R, Bazan J. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci U S A. 1998;95:588-93 pubmed
  28. Jin M, Kim S, Heo J, Lee M, Kim H, Paik S, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007;130:1071-82 pubmed
    TLR2 in association with TLR1 or TLR6 plays an important role in the innate immune response by recognizing microbial lipoproteins and lipopeptides...
  29. Pino Yanes M, Corrales A, Casula M, Blanco J, Muriel A, Espinosa E, et al. Common variants of TLR1 associate with organ dysfunction and sustained pro-inflammatory responses during sepsis. PLoS ONE. 2010;5:e13759 pubmed publisher
    ..Recently, TLR1 gene polymorphisms have been found correlated with whole blood hyper-inflammatory responses to pathogen-associated ..
  30. Mikacenic C, Reiner A, Holden T, Nickerson D, Wurfel M. Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses. Genes Immun. 2013;14:52-7 pubmed publisher
    ..Using a candidate gene approach, we previously identified genetic variation within TLR1 that is associated with hyper-responsiveness to a TLR1/2 agonist in vitro and with death and organ dysfunction in ..
  31. Brightbill H, Libraty D, Krutzik S, Yang R, Belisle J, Bleharski J, et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science. 1999;285:732-6 pubmed
    ..Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens. ..
  32. Schuring R, Hamann L, Faber W, Pahan D, Richardus J, Schumann R, et al. Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. J Infect Dis. 2009;199:1816-9 pubmed publisher
    We investigated the association between a polymorphism of a key innate immunity receptor, Toll-like receptor 1 (TLR1) N248S, and susceptibility to leprosy and its clinical presentation...
  33. Brown V, Brown R, Ozinsky A, Hesselberth J, Fields S. Binding specificity of Toll-like receptor cytoplasmic domains. Eur J Immunol. 2006;36:742-53 pubmed
    ..differ in their ability to associate with MyD88: The TIR of TLR2 binds to MyD88 but the TIR of the closely related TLR1, 6, or 10 do not...
  34. Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley J, et al. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature. 2000;408:111-5 pubmed
    ..Here we report the crystal structures of the TIR domains of human TLR1 and TLR2 and of the Pro681His mutant of TLR2...
  35. Obeid J, Wages N, Hu Y, Deacon D, Slingluff C. Heterogeneity of CD8+ tumor-infiltrating lymphocytes in non-small-cell lung cancer: impact on patient prognostic assessments and comparison of quantification by different sampling strategies. Cancer Immunol Immunother. 2017;66:33-43 pubmed publisher
    ..b>TIL infiltration was associated with survival when sampling the center (p = 0...
  36. Babu S, Blauvelt C, Kumaraswami V, Nutman T. Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation. J Immunol. 2005;175:1170-6 pubmed
    ..To assess the contribution of TLR in mediating this dysregulation, we examined the expression of TLR1, TLR2, TLR4, and TLR9 on B cells and monocytes of filaria-infected and uninfected individuals...
  37. Bronger H, Singer J, Windmüller C, Reuning U, Zech D, Delbridge C, et al. CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer. Br J Cancer. 2016;115:553-63 pubmed publisher
    ..facilitate chemotactic recruitment of TILs, and their intratumoral accumulation is a conceivable way to improve TIL-dependent immune intervention in cancer...
  38. Cai C, Xu Y, Wu Z, Dong Q, Li M, Olson J, et al. Tim-3 expression represents dysfunctional tumor infiltrating T cells in renal cell carcinoma. World J Urol. 2016;34:561-7 pubmed publisher
    ..We investigated the expression and function of Tim-3 on TIL CD4+ T cells and TIL CD8+ T cells from 30 RCC patients...
  39. Golovkin A, Ponasenko A, Khutornaya M, Kutikhin A, Salakhov R, Yuzhalin A, et al. Association of TLR and TREM-1 gene polymorphisms with risk of coronary artery disease in a Russian population. Gene. 2014;550:101-9 pubmed publisher
    ..We revealed that the C/C genotype of the TLR1 rs5743551 polymorphism was significantly associated with a reduced risk of CAD according to the recessive model (OR=..
  40. Roberts C, Caffell A, Filipek Ogden K, Gowland R, Jakob T. 'Til Poison Phosphorous Brought them Death': A potentially occupationally-related disease in a post-medieval skeleton from north-east England. Int J Paleopathol. 2016;13:39-48 pubmed publisher
  41. Heins S, Wolczanski P, Cundari T, MacMillan S. Redox non-innocence permits catalytic nitrene carbonylation by (dadi)Ti 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 000. Chem Sci. 2017;8:3410-3418 pubmed publisher
    ..dadi) m ) ligand to titanium provided adducts (dadi)TiL x (1-L x ; L x = THF, PMe2Ph, (CNMe)2
  42. Stivers N, Pelisch N, Orem B, Williams J, Nally J, Stirling D. The toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury. Exp Neurol. 2017;294:1-11 pubmed publisher
    ..In summary, our data suggest that by providing a second "sterile" activation signal to microglia through TLR2/TLR1 signaling, the microglial response to injury can be modulated in situ and is highly neuroprotective.
  43. Ma M, Xie L, Wu S, Tang F, Li H, Zhang Z, et al. Toll-like receptors, tumor necrosis factor-?, and interleukin-10 gene polymorphisms in risk of pulmonary tuberculosis and disease severity. Hum Immunol. 2010;71:1005-10 pubmed publisher
    ..TB). The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-? (TNF-?), as well as -819 C/T in interleukin-10 ..
  44. Mikacenic C, Schneider A, Radella F, Buckner J, Wurfel M. Cutting edge: Genetic variation in TLR1 is associated with Pam3CSK4-induced effector T cell resistance to regulatory T cell suppression. J Immunol. 2014;193:5786-90 pubmed publisher
    TLR play essential roles in the initiation and modulation of immune responses. TLR1/TLR2 heterodimers recognize triacylated bacterial lipopeptides, including the synthetic TLR1/2 lipopeptide Pam3CSK4...
  45. Gauthier L, Corgnac S, Boutet M, Gros G, Validire P, Bismuth G, et al. Paxillin Binding to the Cytoplasmic Domain of CD103 Promotes Cell Adhesion and Effector Functions for CD8+ Resident Memory T Cells in Tumors. Cancer Res. 2017;77:7072-7082 pubmed publisher
    ..These results also explain the more favorable prognosis associated with retention of TRM cells in the tumor microenvironment. Cancer Res; 77(24); 7072-82. ©2017 AACR. ..
  46. Frey A. The Inhibitory Signaling Receptor Protocadherin-18 Regulates Tumor-Infiltrating CD8+ T-cell Function. Cancer Immunol Res. 2017;5:920-928 pubmed publisher
    ..can result in tumor destruction, showing that lytic dysfunction in CD8+ tumor-infiltrating lymphocytes (TIL) permits tumor growth...
  47. Piao W, Ru L, Toshchakov V. Differential adapter recruitment by TLR2 co-receptors. Pathog Dis. 2016;74: pubmed publisher
    TLR2 heterodimers with TLR1 or TLR6 recognize distinct pathogen-associated molecules such as tri- and di-acylated lipopeptides...
  48. Sánchez Cuaxospa M, Contreras Ramos A, Pérez Figueroa E, Medina Sanson A, Jimenez Hernandez E, Torres Nava J, et al. Low expression of Toll-like receptors in peripheral blood mononuclear cells of pediatric patients with acute lymphoblastic leukemia. Int J Oncol. 2016;49:675-81 pubmed publisher
    ..The aim of the present study was to evaluate the expression of TLR1, TLR3, TLR4, TLR7 and TLR9 in peripheral blood mononuclear cells (PBMCs) in patients with ALL and prior to any ..
  49. Liang Q, Li W, Guo N, Tong C, Zhou Y, Fang W, et al. Identification and Functional Analysis of Interleukin-1? in the Chinese Soft-Shelled Turtle Pelodiscus sinensis. Genes (Basel). 2016;7: pubmed publisher
    ..The full-length cDNA of Pelodiscus sinensis IL-1? (tIL-1?) consists of 1529 base pairs with an 831-base-pair open reading frame, encoding 277 amino acids...
  50. Grayczyk J, Harvey C, Laczkovich I, Alonzo F. A Lipoylated Metabolic Protein Released by Staphylococcus aureus Suppresses Macrophage Activation. Cell Host Microbe. 2017;22:678-687.e9 pubmed publisher
    ..aureus and moonlights as a macrophage immunosuppressant by reducing Toll-like receptor 1/2 (TLR1/2) activation by bacterial lipopeptides...
  51. Taguchi T, Mitcham J, Dower S, Sims J, Testa J. Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14. Genomics. 1996;32:486-8 pubmed
  52. Weiss S, Han J, Darvishian F, Tchack J, Han S, Malecek K, et al. Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts. J Transl Med. 2016;14:299 pubmed
    ..Each age group in the IMCG and TCGA cohorts was stratified by tumor infiltrating lymphocyte (TIL) measurements and tested for association with MSS...
  53. Willie B, Hall N, Stein C, Jurevic R, Weinberg A, Mehlotra R, et al. Association of Toll-like receptor polymorphisms with HIV status in North Americans. Genes Immun. 2014;15:569-77 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes TLR2-4 and TLR7-9, but not in TLR1 and TLR6, have been previously evaluated regarding human immunodeficiency virus (HIV) acquisition and disease progression in ..
  54. Galoian K, Abrahamyan S, Chailyan G, Qureshi A, Patel P, Metser G, et al. Toll like receptors TLR1/2, TLR6 and MUC5B as binding interaction partners with cytostatic proline rich polypeptide 1 in human chondrosarcoma. Int J Oncol. 2018;52:139-154 pubmed publisher
    ..that PRP-1 binding interacting partners belong to innate immunity pattern recognition toll like receptors TLR1/2 and TLR6 and gel forming secreted mucin MUC5B...
  55. Trzpis K, Kasprzycka E, Skotnicka B, Hassmann Poznańska E, Wysocka J. Expression of Toll-like receptors on peripheral blood white cells in acute otitis media. Otolaryngol Pol. 2014;68:77-82 pubmed publisher
    ..The aim of this study was to determine the expression of TLR1, TLR2 and TLR4 on lymphocytes, monocytes and granulocytes in peripheral blood in children with recurrent or ..
  56. Tukel C, Nishimori J, Wilson R, Winter M, Keestra A, van Putten J, et al. Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms. Cell Microbiol. 2010;12:1495-505 pubmed publisher
    ..inhibition of TLR signalling in human macrophage-like (THP-1) cells suggested that TLR2 interacts with TLR1 to recognize curli amyloid fibrils...
  57. James F, Jiminez Linan M, Alsop J, Mack M, Song H, Brenton J, et al. Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer. BMC Cancer. 2017;17:657 pubmed publisher
    ..62, P < 0.001). There was a weak correlation between stromal TIL levels in primary and secondary tumour samples (Spearman's rank correlation = 0.29, P < 0...
  58. Feng L, Qian H, Yu X, Liu K, Xiao T, Zhang C, et al. Heterogeneity of tumor-infiltrating lymphocytes ascribed to local immune status rather than neoantigens by multi-omics analysis of glioblastoma multiforme. Sci Rep. 2017;7:6968 pubmed publisher
    Hypothetically, intratumoral genomic heterogeneity has the potential to foster tumor-infiltrating lymphocyte (TIL) diversity; however, no study has directly tested this hypothesis by simultaneously investigating somatic mutations, TIL ..
  59. Cipriano C, Maiti A, Hale G, Jiranek W. The host response: Toll-like receptor expression in periprosthetic tissues as a biomarker for deep joint infection. J Bone Joint Surg Am. 2014;96:1692-8 pubmed publisher
    ..Mean TLR1 mRNA expression was significantly elevated in infected compared with noninfected samples (0.600 compared with 0...
  60. Nakata T, Yasuda M, Fujita M, Kataoka H, Kiura K, Sano H, et al. CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex. Cell Microbiol. 2006;8:1899-909 pubmed
    It has demonstrated that the recognition of triacylated lipopeptides by Toll-like receptor (TLR) 2 requires TLR1 as a coreceptor...
  61. Su Q, Pfalzgraff A, Weindl G. Cell type-specific regulatory effects of glucocorticoids on cutaneous TLR2 expression and signalling. J Steroid Biochem Mol Biol. 2017;171:201-208 pubmed publisher
    ..less in calcium-induced differentiated keratinocytes but not in HaCaT cells or fibroblasts, however, Dex reduced TLR1/6 expression...
  62. Whitmore L, Hook J, Philiph A, Hilkin B, Bing X, Ahn C, et al. A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis. J Immunol. 2016;196:1376-86 pubmed publisher
    ..revealed that PMN responsiveness to Pam3CSK4 was enhanced by a common single-nucleotide polymorphism (SNP) in TLR1 (rs5743618)...
  63. Xiao W, Liu Z, Lin J, Li J, Wu K, Ma Y, et al. Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease. Autoimmunity. 2015;48:13-8 pubmed publisher
    ..The aim of this study was to evaluate the potential association of polymorphisms in TLR1, TLR6 and TLR10 genes with GD in Chinese Cantonese population. Seven single nucleotide polymorphisms (i.e...
  64. Davis S, Clark E, Nelson L, Silver R. The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis. Am J Obstet Gynecol. 2010;202:308.e1-8 pubmed publisher
    ..025), HSP70-2 1267 (P = .02), and interleukin (IL)-1beta-511 (P = .016). Puerperal group A streptococcal sepsis may be associated with innate immune response gene polymorphisms in TLR9, HSP70-2, and IL1beta. ..
  65. Thornton N, Cody M, Yost C. Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants. Neonatology. 2012;101:140-6 pubmed publisher
    ..express and release different levels of inflammatory cytokines and chemokines in response to stimulation with TLR1-9 agonists...
  66. Brandt K, Fickentscher C, Boehlen F, Kruithof E, de Moerloose P. NF-?B is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes. J Thromb Haemost. 2014;12:779-91 pubmed publisher
    ..We demonstrate that aPLA, but not control IgG, co-localizes with TLR2 and TLR1 or TLR6 on human monocytes...
  67. Kurokawa K, Lee H, Roh K, Asanuma M, Kim Y, Nakayama H, et al. The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2. J Biol Chem. 2009;284:8406-11 pubmed publisher
    ..Moreover, analysis of knock-out mice showed that SitC required TLR2 and MyD88, but not TLR1 or TLR6, for the induction of cytokines. In addition to the S...
  68. Yanagawa M, Uchida K, Ando Y, Tomiyama T, Yamaguchi T, Ikeura T, et al. Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis. J Gastroenterol. 2018;53:449-460 pubmed publisher
    ..and 10 patients with atopic dermatitis, and analyzed activation of basophils by stimulating them with ligands of TLR1-9. We also compared TLR expression in basophils from the tissue and blood samples...
  69. Ahn H, Yang J, Kim H, Chung J, Ahn S, Jeong W, et al. Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma. Oncotarget. 2017;8:66178-66194 pubmed publisher
    ..of OSCC, including high stage, angiolymphatic invasion, perineural invasion, and death, were associated with TIL depletion. High T stage (T4) tumors also had low PD-L1 but had high miR-197 expression...
  70. Schoffelen T, Ammerdorffer A, Hagenaars J, Bleeker Rovers C, Wegdam Blans M, Wever P, et al. Genetic Variation in Pattern Recognition Receptors and Adaptor Proteins Associated With Development of Chronic Q Fever. J Infect Dis. 2015;212:818-29 pubmed publisher
    ..Cytokine production in whole-blood stimulation assays was correlated with relevant genotypes. Polymorphisms in TLR1 (R80T), NOD2 (1007fsX1), and MYD88 (-938C>A) were associated with chronic Q fever...
  71. Harao M, Forget M, Roszik J, Gao H, Babiera G, Krishnamurthy S, et al. 4-1BB-Enhanced Expansion of CD8+ TIL from Triple-Negative Breast Cancer Unveils Mutation-Specific CD8+ T Cells. Cancer Immunol Res. 2017;5:439-445 pubmed publisher
    Triple-negative breast cancer (TNBC) highly infiltrated with CD8+ tumor-infiltrating lymphocytes (TIL) has been associated with improved prognosis...
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    ..A significant re-localization was found in TLR1 expression with a higher percentage of basal and a significantly lower percentage of homogenous epidermal ..