tissue factor pathway inhibitor


Gene Symbol: tissue factor pathway inhibitor
Description: tissue factor pathway inhibitor
Alias: EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor, anti-convertin, extrinsic pathway inhibitor, tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Species: human

Top Publications

  1. Warshawsky I, Bu G, Mast A, Saffitz J, Broze G, Schwartz A. The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo. J Clin Invest. 1995;95:1773-81 pubmed
    b>Tissue factor pathway inhibitor (TFPI) is a plasma Kunitz-type serine protease inhibitor that directly inhibits coagulation Factor Xa and also inhibits tissue factor-initiated coagulation...
  2. Lwaleed B, Bass P. Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol. 2006;208:327-39 pubmed
    ..b>Tissue factor pathway inhibitor (TFPI) is a plasma Kunitz-type serine protease inhibitor, which modulates initiations of coagulation ..
  3. Wun T, Kretzmer K, Girard T, Miletich J, Broze G. Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains. J Biol Chem. 1988;263:6001-4 pubmed
    Human plasma contains a lipoprotein-associated coagulation inhibitor (LACI) which inactivates factor Xa directly, and in a Xa-dependent fashion also inhibits the VIIa-tissue factor complex of the extrinsic coagulation pathway...
  4. Girard T, Warren L, Novotny W, Likert K, Brown S, Miletich J, et al. Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature. 1989;338:518-20 pubmed
    ..Plasma contains a lipoprotein-associated coagulation inhibitor (LACI) which inhibits activated factor X (Xa) directly and, in a Xa-dependent way, inhibits VII(a)/TF activity, ..
  5. Moatti D, Meirhaeghe A, Ollivier V, Bauters C, Amouyel P, de Prost D. Polymorphisms of the tissue factor pathway inhibitor gene and the risk of restenosis after coronary angioplasty. Blood Coagul Fibrinolysis. 2001;12:317-23 pubmed
    ..We investigated a possible relationship between three previously identified polymorphisms of the tissue factor pathway inhibitor (TFPI) gene and restenosis in 443 patients who underwent angioplasty, with or without stent ..
  6. Piro O, Broze G. Comparison of cell-surface TFPIalpha and beta. J Thromb Haemost. 2005;3:2677-83 pubmed
    b>Tissue factor pathway inhibitor (TFPI) is mainly produced by endothelial cells and alternative mRNA splicing generates two forms, TFPIalpha and TFPIbeta...
  7. Kurer M. Protein and mRNA expression of tissue factor pathway inhibitor-1 (TFPI-1) in breast, pancreatic and colorectal cancer cells. Mol Biol Rep. 2007;34:221-4 pubmed
    ..Our results show that one such factor--Tissue Factor Pathway Inhibitor (TFPI-1) is expressed by a number of different cancer cells...
  8. Crawley J, Lane D. The haemostatic role of tissue factor pathway inhibitor. Arterioscler Thromb Vasc Biol. 2008;28:233-42 pubmed
    ..This review article focuses on the major physiological regulator of tissue factor-induced coagulation, tissue factor pathway inhibitor, its expression, anticoagulant function, and its role in normal hemostasis.
  9. Nadir Y, Brenner B, Gingis Velitski S, Levy Adam F, Ilan N, Zcharia E, et al. Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells. Thromb Haemost. 2008;99:133-41 pubmed
    ..heparanase regulates other coagulation modulators, and examined the expression and localization of tissue factor pathway inhibitor (TFPI) following heparanase over-expression or exogenous addition...

More Information

Publications127 found, 100 shown here

  1. Sierko E, Wojtukiewicz M, Zimnoch L, Kisiel W. Expression of tissue factor pathway inhibitor (TFPI) in human breast and colon cancer tissue. Thromb Haemost. 2010;103:198-204 pubmed publisher
    ..principal initiator of blood coagulation activation in cancer patients is tissue factor (TF), while tissue factor pathway inhibitor (TFPI) is the main inhibitor of the TF-dependent pathway of blood coagulation...
  2. Stavik B, Skretting G, Olstad O, Sletten M, Dehli Vigeland M, Sandset P, et al. TFPI alpha and beta regulate mRNAs and microRNAs involved in cancer biology and in the immune system in breast cancer cells. PLoS ONE. 2012;7:e47184 pubmed publisher
    ..Overexpression of TFPI in breast cancer cells affected the expression of mRNAs and miRNAs involved in processes facilitating cancer cell growth and immunologic response, possibly by signal transduction involving the EGFR pathway. ..
  3. Mast A, Acharya N, Malecha M, Hall C, Dietzen D. Characterization of the association of tissue factor pathway inhibitor with human placenta. Arterioscler Thromb Vasc Biol. 2002;22:2099-104 pubmed
    b>Tissue factor pathway inhibitor (TFPI) is an endothelial-associated inhibitor of blood coagulation. Because the mechanism for attachment of TFPI to endothelium is not clear, we investigated its association with human placenta...
  4. Provençal M, Michaud M, Beaulieu E, Ratel D, Rivard G, Gingras D, et al. Tissue factor pathway inhibitor (TFPI) interferes with endothelial cell migration by inhibition of both the Erk pathway and focal adhesion proteins. Thromb Haemost. 2008;99:576-85 pubmed publisher
    b>Tissue factor pathway inhibitor (TFPI) is a plasma Kunitz-type serine protease inhibitor that is mainly known for its inhibition of tissue factor-mediated coagulation...
  5. VAN DEN Boogaard F, Brands X, Schultz M, Levi M, Roelofs J, Van T Veer C, et al. Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia. J Thromb Haemost. 2011;9:122-32 pubmed publisher
    ..Recombinant human tissue factor pathway inhibitor (rh-TFPI) attenuates sepsis-induced coagulation and has been evaluated in clinical trials involving ..
  6. Stavik B, Skretting G, Aasheim H, Tinholt M, Zernichow L, Sletten M, et al. Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility. BMC Cancer. 2011;11:357 pubmed publisher
    ..Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development...
  7. Bajaj M, Birktoft J, Steer S, Bajaj S. Structure and biology of tissue factor pathway inhibitor. Thromb Haemost. 2001;86:959-72 pubmed
    Human tissue factor pathway inhibitor (TFPI) is a modular protein comprised of three Kunitz type domains flanked by peptide segments that are less structured...
  8. Hackeng T, Maurissen L, Castoldi E, Rosing J. Regulation of TFPI function by protein S. J Thromb Haemost. 2009;7 Suppl 1:165-8 pubmed publisher
    Protein S is an anticoagulant cofactor of full-length tissue factor pathway inhibitor (TFPI) that facilitates optimal factor Xa-inhibition and efficient down-regulation of thrombin generation in plasma...
  9. Feng L, Yang X, Shi Y, Liang S, Zhao T, Duan J, et al. Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system. Int J Nanomedicine. 2018;13:7819-7834 pubmed publisher
    ..time (PT), activated partial thromboplastin time (APTT), tissue-type plasminogen activator (t-PA), tissue factor pathway inhibitor (TFPI), and antithrombin III (AT III), were decreased, while those of human fibrinogen (FIB) and D-..
  10. Sobeh M, Mahmoud M, Abdelfattah M, Cheng H, El Shazly A, Wink M. A proanthocyanidin-rich extract from Cassia abbreviata exhibits antioxidant and hepatoprotective activities in vivo. J Ethnopharmacol. 2018;213:38-47 pubmed publisher
    ..HPLC-PDA-ESI-MS/MS analysis resulted in the identification of 57 compounds on the bases of their mass spectra. (epi)-Catechin, (epi)-afzelechin, (epi)-guibourtinidol, and (ent)-cassiaflavan monomers as well as their dimers, trimers,..
  11. Albert V, Arulselvi S, Agrawal D, Pati H, Pandey R. Early posttraumatic changes in coagulation and fibrinolysis systems in isolated severe traumatic brain injury patients and its influence on immediate outcome. Hematol Oncol Stem Cell Ther. 2019;12:32-43 pubmed publisher
    ..8 seconds on admission following iSTBI. Analysis of tissue factor (TF), tissue factor pathway inhibitor (TFPI), protein C (PC), protein S (PS), thrombin/antithrombin complex (TAT), soluble fibrin monomer (..
  12. . [Expert consensus for the diagnosis and treatment of patients with renal impairment of multiple myeloma]. Zhonghua Nei Ke Za Zhi. 2017;56:871-875 pubmed publisher
    ..assess the estimated glomerular filtration rate (eGFR) by creatinine based formula CKD-epidemiology collaboration (EPI) or modification of diet in renal disease(MDRD) and to stage the renal injuries according to 2013 Kidney Disease ..
  13. Wyatt L, Permar S, Ortiz E, Berky A, Woods C, Amouou G, et al. Mercury Exposure and Poor Nutritional Status Reduce Response to Six Expanded Program on Immunization Vaccines in Children: An Observational Cohort Study of Communities Affected by Gold Mining in the Peruvian Amazon. Int J Environ Res Public Health. 2019;16: pubmed publisher
    ..This study evaluates antibody responses to six vaccines from the expanded program on immunization (EPI), including hepatitis B, Haemophilus influenzae type B, measles, pertussis, tetanus, and diphtheria in ..
  14. Aleksandrovych V, Walocha J, Gil K. Telocytes in female reproductive system (human and animal). J Cell Mol Med. 2016;20:994-1000 pubmed publisher
    ..They have been found in a large variety of organs: heart (endo-, myo-, epi- and pericardium, myocardial sleeves, heart valves); digestive tract and annex glands (oesophagus, stomach, ..
  15. Løvvik T, Carlsen S, Salvesen Ø, Steffensen B, Bixo M, Gómez Real F, et al. Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2019;7:256-266 pubmed publisher
    Women with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy complications. Epi-analysis of two previous randomised controlled trials that compared metformin with placebo during pregnancy in women with PCOS showed a ..
  16. Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
    ..Zebrafish fed on transgenic Artemia expressing CMV-gfp-epi combined with commercial fodder were more resistant to infection by V...
  17. Ba I, Ba A, Faye P, Diouf F, Sagna A, Thiongane A, et al. [Particularities of liver abscesses in children in Senegal: Description of a series of 26 cases]. Arch Pediatr. 2016;23:491-6 pubmed publisher
    ..The data were analyzed with Epi-info (P<0.05 was considered significant)...
  18. Modica M, Lombardo F, Franchini P, Oliverio M. The venomous cocktail of the vampire snail Colubraria reticulata (Mollusca, Gastropoda). BMC Genomics. 2015;16:441 pubmed publisher
  19. Endeshaw M, Abebe F, Bedimo M, Asart A. Diet and Pre-eclampsia: A Prospective Multicentre Case-Control Study in Ethiopia. Midwifery. 2015;31:617-24 pubmed publisher
    ..b>Epi Info 3.5.3 was used for data entry and cleaning, while IBM SPSS Statistics 20 was used for data analysis...
  20. Hu W, Hao H, Yu W, Wu X, Zhou H. Association of elevated glycosylated hemoglobin A1c with hyperfiltration in a middle-aged and elderly Chinese population with prediabetes or newly diagnosed diabetes: a cross-sectional study. BMC Endocr Disord. 2015;15:47 pubmed publisher
    ..The estimated glomerular filtration rate (eGFR) was calculated from creatinine levels using the CKD-EPI formula. Hyperfiltration was defined as eGFR >90(th) percentile...
  21. Gutiérrez Salmeán G, Meaney E, Lanaspa M, Cicerchi C, Johnson R, Dugar S, et al. A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects. Int J Cardiol. 2016;223:500-506 pubmed publisher
    ..However, they often exhibit poor long-term patient compliance. Nutraceutics, including (-)-epicatechin (EPI), have gained increasing interest as coadjuvant effective and safe therapies that are able to attenuate ..
  22. Garcia Covarrubias L, Ventura E, Soto V, Gonzalez E, Garcia A, Aguilar J, et al. Lack of Association Between Elevated Urinary Levels of Interleukin-10 and Interferon Gamma With the Presence of Inflammation in Kidney Transplant Recipients. Transplant Proc. 2016;48:583-7 pubmed publisher
    ..index (BMI), gender, transplant type, creatinine, chronic kidney disease epidemiology collaboration equation, (CKD-EPI), modification of diet in renal disease study equation (MDRD), Banff classification, and levels of IL-10 and INF-?...
  23. Wesseling C, Aragon A, González M, Weiss I, Glaser J, Rivard C, et al. Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua. BMJ Open. 2016;6:e011034 pubmed publisher
    ..of CKD risk factors between workers with reduced estimated glomerular filtration rate (eGFRCKD-EPI <80 mL/min/1...
  24. Poorani R, Bhatt A, Dwarakanath B, Das U. COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance. Eur J Pharmacol. 2016;785:116-132 pubmed publisher
    ..and lipoxygenase (LOX) inhibitory action and enhances the production of anti-inflammatory lipoxin A4 {(called as epi-lipoxin A4, aspirin-triggered lipoxins (ATLs))}...
  25. Baranasic D, Oppermann T, Cheaib M, Cullum J, Schmidt H, Simon M. Genomic characterization of variable surface antigens reveals a telomere position effect as a prerequisite for RNA interference-mediated silencing in Paramecium tetraurelia. MBio. 2014;5:e01328 pubmed publisher
    ..Using the ciliate Paramecium tetraurelia as a (epi)genetic model, we showed that a subtelomeric gene position effect is associated with the selective occurrence of ..
  26. Lv P, Zhao M, Liu Y, Jin H, Cui W, Fan C, et al. Apolipoprotein C-III in the high-density lipoprotein proteome of cerebral lacunar infarction patients impairs its anti-inflammatory function. Int J Mol Med. 2018;41:61-68 pubmed publisher
    ..In the current study, the HDL proteomes in patients with cerebral lacunar infarction (LACI) and control subjects were investigated...
  27. Wu X, Darlington D, Cap A. Procoagulant and fibrinolytic activity after polytrauma in rat. Am J Physiol Regul Integr Comp Physiol. 2016;310:R323-9 pubmed publisher
    ..Plasminogen activator inhibitor-1 was significantly elevated at 2-4 h. Neither tissue factor pathway inhibitor nor thrombin activatable fibrinolysis inhibitor changed significantly over time...
  28. Avinash S, Singh V, Agarwal A, Chatterjee S, Araya V. Identification and Stratification of Diabetic Kidney Disease Using Serum Cystatin C and Serum Creatinine Based Estimating Equations in Type 2 Diabetes: A Comparative Analysis. J Assoc Physicians India. 2015;63:28-35 pubmed
    ..Cockcroft-Gault formula, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease-Epidemiology (CKD-EPI) Cys C formula. The three sets of eGFR were compared using repeated measure ANOVA...
  29. Zeng Y, Quek Y, Kee C, Low M, Bloodworth B, Ge X. Analysis of 32 toxic natural substances in herbal products by liquid chromatography quadrupole linear ion trap mass spectrometry. J Pharm Biomed Anal. 2015;115:169-73 pubmed publisher
    In this study, an LC-MS/MS EPI method was developed for simultaneous determination of 32 toxic natural substances in herbal products...
  30. Fan F, Shi M, Nie Y, Zhao Y, Ye J, Liang Y. Differential behaviors of tea catechins under thermal processing: Formation of non-enzymatic oligomers. Food Chem. 2016;196:347-54 pubmed publisher
    ..The epimerization of non-gallated catechins was favored by epi-configuration but hindered by pyrogallol moiety, and the hydrolysis reaction of gallated catechins was facilitated ..
  31. Zhang T, Zhou S, Hu L, Peng B, Liu Y, Luo X, et al. Polysialic acid-modifying liposomes for efficient delivery of epirubicin, in-vitro characterization and in-vivo evaluation. Int J Pharm. 2016;515:449-459 pubmed publisher
    ..The PSA-BS18 modified liposomal epirubicin (EPI-SL), had a particle size of 133.63±0.92nm, a zeta potential of -26.23±1...
  32. Park H, Brannon P, West A, Yan J, Jiang X, Perry C, et al. Maternal vitamin D biomarkers are associated with maternal and fetal bone turnover among pregnant women consuming controlled amounts of vitamin D, calcium, and phosphorus. Bone. 2017;95:183-191 pubmed publisher
    ..021) with fetal CTx. Similarly, maternal 3-epi-25(OH)D3 was negatively related (P?0.037) to maternal NTx and deoxypyridinoline at study-end...
  33. Hilbert F, Wech T, Neubauer H, Veldhoen S, Bley T, Köstler H. Comparison of Turbo Spin Echo and Echo Planar Imaging for intravoxel incoherent motion and diffusion tensor imaging of the kidney at 3Tesla. Z Med Phys. 2017;27:193-201 pubmed publisher
    Echo Planar Imaging (EPI) is most commonly applied to acquire diffusion-weighted MR-images. EPI is able to capture an entire image in very short time, but is prone to distortions and artifacts...
  34. Amini Nekoo A, Futers T, Moia M, Mannucci P, Grant P, Ariëns R. Analysis of the tissue factor pathway inhibitor gene and antigen levels in relation to venous thrombosis. Br J Haematol. 2001;113:537-43 pubmed
    b>Tissue factor pathway inhibitor (TFPI) inhibits tissue factor-induced coagulation. The major part of TFPI is releasable by heparin...
  35. Malouf G, Su X, Zhang J, Creighton C, Ho T, Lu Y, et al. DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas. Clin Cancer Res. 2016;22:6236-6246 pubmed
    ..Our data provide the first mapping of methylome epi-signature and indicate that RCC subtypes can be grouped into two major epi-clusters: C1, which encompasses clear-..
  36. Li X, Zeng D, Chen Y, Ding L, Li W, Wei T, et al. Role of alpha- and beta-adrenergic receptors in cardiomyocyte differentiation from murine-induced pluripotent stem cells. Cell Prolif. 2017;50: pubmed publisher
    ..whether ARs regulated miPSC differentiation into cardiac lineages, effects of the AR agonist, epinephrine (EPI), on miPSC differentiation and underlying signalling mechanisms, were evaluated...
  37. Müssigbrodt A, Efimova E, Knopp H, Bertagnolli L, Dagres N, Richter S, et al. Should all patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy undergo epicardial catheter ablation?. J Interv Card Electrophysiol. 2017;48:193-199 pubmed publisher
    ..was to examine an inducibility-guided ablation approach by comparing the long-term results between endocardial and epi-endocardial radiofrequency catheter ablation of VT in a large cohort of patients with ARVD/C...
  38. Chong E, Ho E, Baldevarona Llego J, Chan M, Wu L, Tay L. Frailty and Risk of Adverse Outcomes in Hospitalized Older Adults: A Comparison of Different Frailty Measures. J Am Med Dir Assoc. 2017;18:638.e7-638.e11 pubmed publisher
    ..scale of fatigue, resistance, ambulation, illnesses, and loss of weight) (FRAIL), Tilburg Frailty Indicator (TFI), and Clinical Frailty Scale (CFS)] in identifying frailty, using the widely adopted Frailty Index (FI) as "gold ..
  39. Dong L, Liu N, Tian X, Qiao X, Gobbens R, Kane R, et al. Reliability and validity of the Tilburg Frailty Indicator (TFI) among Chinese community-dwelling older people. Arch Gerontol Geriatr. 2017;73:21-28 pubmed publisher
    To translate the Tilburg Frailty Indicator (TFI) into Chinese and assess its reliability and validity...
  40. Rodríguez Roca G, Segura Fragoso A, Villarín Castro A, Alonso Moreno F, Rodriguez Padial L, Rodríguez García M, et al. [Characteristics and cardiovascular events in a general population included in the RICARTO (RIesgo CARdiovascular TOledo) study: Data from the first 1,500 individuals included in the study]. Semergen. 2018;44:180-191 pubmed publisher
    ..3% (oscillometric device), microalbuminuria, 4.3%, sub-clinical renal disease, 3.2%, and nephropathy in 3.8% (CKD-EPI). At least one CVD was reported in 9.2% of cases. A low CVR (SCORE) was present in 44.6% of individuals...
  41. Winckers K, Ten Cate Hoek A, Beekers K, Erkens P, Hamulyak K, ten Cate H, et al. Impaired tissue factor pathway inhibitor function is associated with recurrent venous thromboembolism in patients with first unprovoked deep venous thrombosis. J Thromb Haemost. 2012;10:2208-11 pubmed publisher
  42. Blake Crabb E, Franco R, Bowen M, Huang C, Caslin H, Acevedo E. G protein-coupled receptor kinase-2 in peripheral blood mononuclear cells following acute mental stress. Life Sci. 2016;145:184-9 pubmed publisher
    ..Heart rate was measured at baseline and throughout mental stress. Plasma epinephrine (EPI), norepinephrine (NE), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) were assessed via enzyme-..
  43. Jiang W, Zhou I, Wen L, Zhou X, Sun P. A theoretical analysis of chemical exchange saturation transfer echo planar imaging (CEST-EPI) steady state solution and the CEST sensitivity efficiency-based optimization approach. Contrast Media Mol Imaging. 2016;11:415-423 pubmed publisher
    ..The sensitivity efficiency-based optimization approach could simplify and guide imaging of CEST agents, including glycogen, glucose, creatine, gamma-aminobutyric acid and glutamate. Copyright © 2016 John Wiley & Sons, Ltd. ..
  44. González Quiroz M, Camacho A, Faber D, Aragón A, Wesseling C, Glaser J, et al. Rationale, description and baseline findings of a community-based prospective cohort study of kidney function amongst the young rural population of Northwest Nicaragua. BMC Nephrol. 2017;18:16 pubmed publisher
    ..Glomerular filtration rate (eGFR) was estimated with CKD-EPI equation, along with clinical measurements, questionnaires, biological and environmental samples to evaluate ..
  45. Tamblyn J, Susarla R, Jenkinson C, Jeffery L, Ohizua O, Chun R, et al. Dysregulation of maternal and placental vitamin D metabolism in preeclampsia. Placenta. 2017;50:70-77 pubmed publisher
    ..Conversely, PET sera showed highest levels of the catabolites 3-epi-25(OH)D3 and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3)...
  46. Bagai J, LITTLE B, Banerjee S. Association between arterial access site and anticoagulation strategy on major bleeding and mortality: A historical cohort analysis in the Veteran population. Cardiovasc Revasc Med. 2018;19:95-101 pubmed publisher
    ..shown reduction in major bleeding with trans-radial intervention (TRI) compared with trans-femoral intervention (TFI), and with use of bivalirudin compared with heparin+glycoprotein IIb/IIIa inhibitors (GPI)...
  47. Lopomo A, Coppede F. Pharmacoepigenetics and pharmacoepigenomics of gastrointestinal cancers. Expert Rev Gastroenterol Hepatol. 2018;12:49-62 pubmed publisher
    ..Similarly, single-agent or combined strategies with high doses of drugs that target epigenetic modifications (epi-drugs) were scarcely tolerated by the patients, and current research has moved to their combination with standard ..
  48. Ephraim R, Osakunor D, Cudjoe O, Oduro E, Asante Asamani L, Mitchell J, et al. Chronic kidney disease is common in sickle cell disease: a cross-sectional study in the Tema Metropolis, Ghana. BMC Nephrol. 2015;16:75 pubmed publisher
    ..The estimated GFR (eGFR) was calculated using the CKD-EPI and Schwartz equations...
  49. Elli F, Bordogna P, de Sanctis L, Giachero F, Verrua E, Segni M, et al. Screening of PRKAR1A and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism. J Bone Miner Res. 2016;31:1215-24 pubmed publisher
    ..about 30% of AHO/PHP patients still lack a molecular diagnosis, hence the need to screen patients negative for GNAS epi/genetic defects also for chromosomal regions and genes associated with diseases that undergo differential diagnosis ..
  50. Halstead D, Abid J, Sloan L, Meza D, Ramsey Walker D, Hata D. A multi-laboratory comparison of two molecular methods for the detection of toxigenic Clostridium difficile. J Infect Dev Ctries. 2016;10:62-7 pubmed publisher
    ..difficile Epi RUO RT-PCR assay (XPCR) which targets toxin B (Cepheid, Sunnyvale, CA) and a laboratory-developed PCR (LDPCR) which ..
  51. Kinsella J, Oliver Tobin W, Tierney S, Feeley T, Egan B, Coughlan T, et al. Assessment of 'on-treatment platelet reactivity' and relationship with cerebral micro-embolic signals in asymptomatic and symptomatic carotid stenosis. J Neurol Sci. 2017;376:133-139 pubmed publisher
    ..function/reactivity was assessed with the PFA-100® to measure collagen-ADP (C-ADP) and collagen-epinephrine (C-EPI) closure times in citrate-anticoagulated whole blood...
  52. Fu S, Hong H, Lu S, Hu C, Xu H, Li Q, et al. Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice. PLoS ONE. 2017;12:e0181948 pubmed publisher
    ..Acupuncture, in turn, reduced body weight and the ratio of epididymal white adipose tissue (Epi-WAT) to body weight, and it also decreased plasma concentrations of glucose, triglyceride, and cholesterol...
  53. Tchoukoua A, Hasegawa R, Hendracipta K, Sato S, Koseki T, Shiono Y. Structure elucidation of new fusarielins from Fusarium sp. and their antimicrobial activity. Magn Reson Chem. 2018;56:32-36 pubmed publisher
    Three new fusarielins, 3-epi-fusarielin H (1), 3-O-methyl-fusarielin H (2), and 3-O-methyl-epi-fusarielin H (3), were isolated from the fungus Fusarium sp. together with the known analogues, fusarielins F (4) and G (5)...
  54. Viessmann O, MOLLER H, Jezzard P. Dual regression physiological modeling of resting-state EPI power spectra: Effects of healthy aging. Neuroimage. 2019;187:68-76 pubmed publisher
    ..dual regression analysis in the frequency domain to model single voxel power spectra of echo planar imaging (EPI) data using external recordings of the cardiac and respiratory cycles as input...
  55. Hababeh M, Zeidan W, El Kader M, Thaher A, Kassim N, Habash E, et al. Contraceptive use by Palestine refugee mothers of young children attending UNRWA clinics: a cross-sectional follow-up study. Lancet. 2018;391 Suppl 2:S26 pubmed publisher
    ..A sample size of 10 478 participants was calculated on the basis of contraceptive use in 2010, using Epi Info sample size calculation...
  56. Ognibene A, Grandi G, Lorubbio M, Rapi S, Salvadori B, Terreni A, et al. KDIGO 2012 Clinical Practice Guideline CKD classification rules out creatinine clearance 24 hour urine collection?. Clin Biochem. 2016;49:85-9 pubmed publisher
    ..the classification assessed from CrCl (creatinine clearance 24h urine collection) and e-GFR calculated with CKD-EPI or MDRD formulas...
  57. Sepehry A, Lang D, Hsiung G, Rauscher A. Prevalence of Brain Microbleeds in Alzheimer Disease: A Systematic Review and Meta-Analysis on the Influence of Neuroimaging Techniques. AJNR Am J Neuroradiol. 2016;37:215-22 pubmed publisher
    ..The aggregate prevalence of microbleeds was 24% (95% CI, 19%-28%). Scan (SWI = 40%, gradient echo = 18%, EPI = 19%) and field strength (slope = 0.39; standard error = 15, P < .01) influenced the prevalence of microbleeds...
  58. Kalthan E, Dondo Fongbia J, Yambele S, Dieu Creer L, Zepio R, Pamatika C. [Twelve cases of monkeypox virus outbreak in Bangassou District (Central African Republic) in December 2015]. Bull Soc Pathol Exot. 2016;109:358-363 pubmed publisher
    ..Our data were analyzed with Epi info7. In total 12 patients had been registered including 9 secondary cases...
  59. Bratseth V, Byrkjeland R, Njerve I, Solheim S, Arnesen H, Seljeflot I. Procoagulant activity in patients with combined type 2 diabetes and coronary artery disease: No effects of long-term exercise training. Diab Vasc Dis Res. 2017;14:144-151 pubmed publisher
    ..Blood was collected at inclusion and after 12?months. Tissue factor, free and total tissue factor pathway inhibitor, prothrombin fragment 1?+?2 (F1?+?2) and D-dimer were determined by enzyme-linked immunosorbent assay ..
  60. de Granda Orive J, Alonso Arroyo A, López Padilla D, Segrelles Calvo G, Jimenez Ruiz C, Solano Reina S. [Bibliometric analysis of IBERPOC and EPI-SCAN studies. Contribution of the smoking variable on the iberpoc study]. Semergen. 2018;44:90-99 pubmed publisher
    The aim of this study was to perform a bibliometric analysis of EPI-SCAN and IBERPOC studies using the Science Citation Index and Scopus databases, and to determine the overall impact with the impact of smoking on IBERPOC as a secondary ..
  61. Pawełczyk T, Grancow Grabka M, Trafalska E, Szemraj J, Pawełczyk A. Oxidative stress reduction related to the efficacy of n-3 polyunsaturated fatty acids in first episode schizophrenia: Secondary outcome analysis of the OFFER randomized trial. Prostaglandins Leukot Essent Fatty Acids. 2017;121:7-13 pubmed publisher
    ..Total plasma antioxidant capacity and 8-epi-isoprostane F2α content were assessed at baseline and at weeks 8 and 26 of the study as secondary ..
  62. Phelan J, de Sessions P, Tientcheu L, Perdigão J, Machado D, Hasan R, et al. Methylation in Mycobacterium tuberculosis is lineage specific with associated mutations present globally. Sci Rep. 2018;8:160 pubmed publisher
    ..Insights into lineage-specific methylomes will further elucidate underlying biological mechanisms and other important phenotypes of the epi-genome.
  63. Santiago L, Gobbens R, van Assen M, Carmo C, Ferreira D, Mattos I. Predictive validity of the Brazilian version of the Tilburg Frailty Indicator for adverse health outcomes in older adults. Arch Gerontol Geriatr. 2018;76:114-119 pubmed publisher
    This study aimed to determine the predictive value of the Brazilian Tilburg Frailty Indicator (TFI) for adverse health outcomes (falls, hospitalization, disability and death), in a follow-up period of twelve months...
  64. Erez O, Espinoza J, Chaiworapongsa T, Gotsch F, Kusanovic J, Than N, et al. A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor. J Matern Fetal Neonatal Med. 2008;21:732-44 pubmed publisher
    ..This study was conducted to determine the behaviour of maternal TF and its natural inhibitor, the tissue factor pathway inhibitor (TFPI) in PPROM...
  65. Knappe S, Gorczyca M, Jilma B, Derhaschnig U, Hartmann R, Palige M, et al. Plasmatic tissue factor pathway inhibitor is a major determinant of clotting in factor VIII inhibited plasma or blood. Thromb Haemost. 2013;109:450-7 pubmed publisher
    b>Tissue factor pathway inhibitor (TFPI) is a major inhibitor of coagulation. We therefore hypothesised that high plasmatic TFPI levels are associated with impaired ex vivo clotting in a model of acquired haemophilia...
  66. Kim E, Rich J, Karoutas A, Tarlykov P, Cochet E, Malysheva D, et al. ZNF555 protein binds to transcriptional activator site of 4qA allele and ANT1: potential implication in Facioscapulohumeral dystrophy. Nucleic Acids Res. 2015;43:8227-42 pubmed publisher
    Facioscapulohumeral dystrophy (FSHD) is an epi/genetic satellite disease associated with at least two satellite sequences in 4q35: (i) D4Z4 macrosatellite and (ii) β-satellite repeats (BSR), a prevalent part of the 4qA allele...
  67. Habte F, Demissie M. Magnitude and factors associated with institutional delivery service utilization among childbearing mothers in Cheha district, Gurage zone, SNNPR, Ethiopia: a community based cross sectional study. BMC Pregnancy Childbirth. 2015;15:299 pubmed publisher
    ..Data was entered and analyzed using Epi Info Version 7 and SPSS Version 16. Frequencies and binary logistic regression were done...
  68. Carillo C, Pecoraro Y, Anile M, Mantovani S, Oliva A, D Abramo A, et al. Evaluation of Renal Function in Patients Undergoing Lung Transplantation. Transplant Proc. 2017;49:699-701 pubmed publisher
    ..Modification of Diet in Renal Disease (MDRD), and Levey's Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. In 20 patients (90%) eGFR was calculated at 1, 3, and 6 months...
  69. Gordon J, Hansen R, Shin P, Feng Y, Vigneron D, Larson P. 3D hyperpolarized C-13 EPI with calibrationless parallel imaging. J Magn Reson. 2018;289:92-99 pubmed publisher
    ..corresponding sampling strategies to accelerate and undersample hyperpolarized 13C data using 3D blipped EPI acquisitions and multichannel receive coils, and demonstrated its application in a human study of [1-13C]..
  70. Singu B, Mubita M, Thikukutu M, Mufenda J, McKenzie S, Verbeeck R. Monitoring of gentamicin serum concentrations in obstetrics and gynaecology patients in Namibia. Int J Clin Pharm. 2018;40:520-525 pubmed publisher
    ..rate (eGFR) by the Modified Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations...
  71. Gibson C, MacLennan A, Dekker G, Goldwater P, Sullivan T, Munroe D, et al. Candidate genes and cerebral palsy: a population-based study. Pediatrics. 2008;122:1079-85 pubmed publisher
    ..Some of these associations support previous findings. There may be a genetic contribution to cerebral palsy risk, and additional investigation is warranted of genes and gene-environment interactions in cerebral palsy. ..
  72. Chang H, Chen N. Joint correction of Nyquist artifact and minuscule motion-induced aliasing artifact in interleaved diffusion weighted EPI data using a composite two-dimensional phase correction procedure. Magn Reson Imaging. 2016;34:974-9 pubmed publisher
    Diffusion-weighted imaging (DWI) obtained with interleaved echo-planar imaging (EPI) pulse sequence has great potential of characterizing brain tissue properties at high spatial-resolution...
  73. Abu Kassim N, Shaw P, Hewavitharana A. Simultaneous determination of 12 vitamin D compounds in human serum using online sample preparation and liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2018;1533:57-65 pubmed publisher
    ..of all 12 vitamin D compounds, including the chromatographic separation of 25(OH)D3 from the isomer 3-epi-25(OH)D3 was achieved...
  74. Agledahl I, Brodin E, Svartberg J, Hansen J. Plasma free tissue factor pathway inhibitor (TFPI) levels and TF-induced thrombin generation ex vivo in men with low testosterone levels. Thromb Haemost. 2009;101:471-7 pubmed
    ..Experimental studies have shown increased synthesis and release of tissue factor pathway inhibitor (TFPI) by physiological levels of testosterone in endothelial cells...
  75. Hackeng T, Seré K, Tans G, Rosing J. Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. Proc Natl Acad Sci U S A. 2006;103:3106-11 pubmed
    ..Our data suggest that protein S deficiency not only increases the risk of thrombosis by impairing the protein C system but also by reducing the ability of TFPI to down-regulate the extrinsic coagulation pathway. ..
  76. Chen Y, Zhang L, Wang G, Zeng H, Lu B, Shen X, et al. Adiponectin inhibits tissue factor expression and enhances tissue factor pathway inhibitor expression in human endothelial cells. Thromb Haemost. 2008;100:291-300 pubmed
    ..b>Tissue factor pathway inhibitor (TFPI) is a specific physiological inhibitor of TF/FVIIa complex that regulates TF-induced ..
  77. Justino A, Pereira M, Vilela D, Peixoto L, Martins M, Teixeira R, et al. Peel of araticum fruit (Annona crassiflora Mart.) as a source of antioxidant compounds with ?-amylase, ?-glucosidase and glycation inhibitory activities. Bioorg Chem. 2016;69:167-182 pubmed publisher
    ..HPLC-ESI-MS/MS analysis identified various biomolecules known as potent antioxidants, such as chlorogenic acid, (epi)catechin, procyanidins, caffeoyl-hexosides, quercetin-glucosides and kaempferol. The fruit peel of A...
  78. Chakhoyan A, Leu K, Pope W, Cloughesy T, Ellingson B. Improved Spatiotemporal Resolution of Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors Using Simultaneous Multi-Slice Echo-Planar Imaging. AJNR Am J Neuroradiol. 2018;39:43-45 pubmed publisher
    ..In the current article, we demonstrate how simultaneous multi-slice EPI can be used to improve DSC-MR imaging spatiotemporal resolution in patients with glioblastoma.
  79. Chen F, Li D, Shen H, Wang C, Li E, Xing H, et al. Polysaccharides from Trichosanthes Fructus via Ultrasound-Assisted Enzymatic Extraction Using Response Surface Methodology. Biomed Res Int. 2017;2017:6160785 pubmed publisher
    ..The results suggest that Trichosanthes Fructus and TFPI could be a novel potent natural medicine with antioxidant and antitumor activities. ..
  80. Cao H, Liu W, Chang Y, Chen H, Zhang Y, Xu W, et al. 5'-Epi-SPA-6952A, a new insecticidal 24-membered macrolide produced by Streptomyces diastatochromogenes SSPRC-11339. Nat Prod Res. 2017;:1-6 pubmed publisher
    A new 24-membered macrolide, 5'-epi-SPA-6952A (1), was isolated from the cultured broth of Streptomyces diastatochromogenes...
  81. Gozal D, Thiriet P, Cottet Emard J, Wouassi D, Bitanga E, Geyssant A, et al. Glucose administration before exercise modulates catecholaminergic responses in glycogen-depleted subjects. J Appl Physiol (1985). 1997;82:248-56 pubmed
    In glycogen-depleted subjects (GD) a nonlinear increase in epinephrine (Epi) and norepinephrine (NE) parallels blood lactate (La) during graded exercise...
  82. Nooshabadi F, Yang H, Cheng Y, Durkee M, Xie H, Rao J, et al. Intravital excitation increases detection sensitivity for pulmonary tuberculosis by whole-body imaging with ?-lactamase reporter enzyme fluorescence. J Biophotonics. 2017;10:821-829 pubmed publisher
    ..illumination of the lung to excite this probe, sensitivity of the optical system increases over trans- and epi-illumination methods of whole-body fluorescence imaging...
  83. Jung S, Hwang J, Kim S, Young Kyu K, Park H, Lee H. The potentiating effect of hTFPI in the presence of hCD47 reduces the cytotoxicity of human macrophages. Xenotransplantation. 2017;24: pubmed publisher
    ..b>Tissue factor pathway inhibitor (TFPI) is involved in the regulation of the coagulation pathway and is able to bind to another ligand ..
  84. Li Y, Chang L, Chen H, Yen C, Pan K, Huang B, et al. Phosphor-Free InGaN White Light Emitting Diodes Using Flip-Chip Technology. Materials (Basel). 2017;10: pubmed publisher
    ..Our results show true potential in the Epi-ready GaN white LEDs for future solid state lighting applications.
  85. Zhang J, Kinoh H, Hespel L, Liu X, Quader S, Martin J, et al. Effective treatment of drug resistant recurrent breast tumors harboring cancer stem-like cells by staurosporine/epirubicin co-loaded polymeric micelles. J Control Release. 2017;264:127-135 pubmed publisher
    ..Here, we studied the ability of polymeric micelles cooperatively loading the cytotoxic drug epirubicin (Epi) and the CSC inhibitor staurosporine (STS) to treat breast tumors, particularly when tumors relapsed after ..
  86. Abbondanza M, Felice V, Abbondanza G. [Peripheral corneal cross-linking (P-CXL) for ultrathin corneas with severe keratoconus: a new technique]. Vestn Oftalmol. 2017;133:65-67 pubmed publisher
    ..thickness of less than 400 µm, leaving the ophthalmic surgeon no option, but to perform transepithelial CXL (epi-on), usually regarded as less effective...
  87. Wen J, Chen Y, Huang Y, Lu Y, Liu X, Zhou H, et al. Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population. Kidney Blood Press Res. 2017;42:1141-1154 pubmed publisher
    ..However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood.
  88. Febbraio M, Lambert D, Starkie R, Proietto J, Hargreaves M. Effect of epinephrine on muscle glycogenolysis during exercise in trained men. J Appl Physiol (1985). 1998;84:465-70 pubmed
    ..One week later, after determination of plasma epinephrine levels in Con, subjects performed the second trial (Epi) with an epinephrine infusion, which resulted in a twofold higher (P < 0...
  89. Djekić Ivanković M, Lavery P, Agellon S, Weiler H. The C-3? Epimer of 25-Hydroxycholecalciferol from Endogenous and Exogenous Sources Supports Normal Growth and Bone Mineral Density in Weanling Rats. J Nutr. 2017;147:141-151 pubmed publisher
    The C-3? epimer of 25-hydroxycholecalciferol [3-epi-25(OH)D3] is elevated in infants...
  90. Ortiz de García S, Garcia Encina P, Irusta Mata R. The potential ecotoxicological impact of pharmaceutical and personal care products on humans and freshwater, based on USEtox™ characterization factors. A Spanish case study of toxicity impact scores. Sci Total Environ. 2017;609:429-445 pubmed publisher
    ..ecotoxicity and human health effects were collected from experimental data, recognized databases or estimated using EPI Suite™ and the USEtox™ software, and were subsequently used for estimating CFs...
  91. Murata Y, Bundo M, Ueda J, Kubota Sakashita M, Kasai K, Kato T, et al. DNA methylation and hydroxymethylation analyses of the active LINE-1 subfamilies in mice. Sci Rep. 2017;7:13624 pubmed publisher
    ..examine methylcytosine (mC) and hydroxymethylcytosine (hmC) levels of the three active LINE-1 subfamilies in mice (TfI, A, and GfII)...
  92. Probandt D, Eickhorst T, Ellrott A, Amann R, Knittel K. Microbial life on a sand grain: from bulk sediment to single grains. ISME J. 2017;: pubmed publisher
    ..Colonization was patchy, with exposed areas largely devoid of any epi-growth (mean cell-cell distance 4.5±5.9??m) and protected areas more densely populated (0.5±0.7??m)...