tissue factor

Summary

Gene Symbol: tissue factor
Description: coagulation factor III, tissue factor
Alias: CD142, TFA, tissue factor, coagulation factor III (thromboplastin, tissue factor)
Species: human
Products:     tissue factor

Top Publications

  1. Yu J, May L, Lhotak V, Shahrzad S, Shirasawa S, Weitz J, et al. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood. 2005;105:1734-41 pubmed
    b>Tissue factor (TF) is the primary cellular initiator of blood coagulation and a modulator of angiogenesis and metastasis in cancer...
  2. Zwicker J. Predictive value of tissue factor bearing microparticles in cancer associated thrombosis. Thromb Res. 2010;125 Suppl 2:S89-91 pubmed publisher
    ..Elevations in circulating tissue factor bearing microparticles are associated with thrombosis in cancer patients...
  3. Butenas S, Orfeo T, Mann K. Tissue factor in coagulation: Which? Where? When?. Arterioscler Thromb Vasc Biol. 2009;29:1989-96 pubmed publisher
    b>Tissue factor (TF) is an integral membrane protein, normally separated from the blood by the vascular endothelium, which plays a key role in the initiation of blood coagulation...
  4. Versteeg H, Schaffner F, Kerver M, Petersen H, Ahamed J, Felding Habermann B, et al. Inhibition of tissue factor signaling suppresses tumor growth. Blood. 2008;111:190-9 pubmed
    Coagulation activation by tissue factor (TF) is implicated in cancer progression, cancer-associated thrombosis and metastasis. The role of direct TF signaling pathways in cancer, however, remains incompletely understood...
  5. Waters E, Yegneswaran S, Morrissey J. Raising the active site of factor VIIa above the membrane surface reduces its procoagulant activity but not factor VII autoactivation. J Biol Chem. 2006;281:26062-8 pubmed
    b>Tissue factor, the physiologic trigger of blood clotting, is the membrane-anchored protein cofactor for the plasma serine protease, factor VIIa...
  6. Redecha P, Van Rooijen N, Torry D, Girardi G. Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury. Blood. 2009;113:4101-9 pubmed publisher
    ..CBA/J mice) that shares features with human recurrent miscarriage and fetal growth restriction, we identified tissue factor (TF) as an essential participating factor in placental and fetal injury...
  7. Brambilla M, Camera M, Colnago D, Marenzi G, De Metrio M, Giesen P, et al. Tissue factor in patients with acute coronary syndromes: expression in platelets, leukocytes, and platelet-leukocyte aggregates. Arterioscler Thromb Vasc Biol. 2008;28:947-53 pubmed publisher
  8. Aharon A, Brenner B, Katz T, Miyagi Y, Lanir N. Tissue factor and tissue factor pathway inhibitor levels in trophoblast cells: implications for placental hemostasis. Thromb Haemost. 2004;92:776-86 pubmed
    ..The aim of this study was to evaluate the levels of tissue factor (TF) and its inhibitors, tissue factor pathway inhibitor (TFPI, TFPI-2), in STB model within hemostatic and ..
  9. Bastarache J, Wang L, Wang Z, Albertine K, Matthay M, Ware L. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Physiol Lung Cell Mol Physiol. 2008;294:L874-81 pubmed publisher
    The alveolar compartment in acute lung injury contains high levels of tissue factor (TF) procoagulant activity favoring fibrin deposition...

More Information

Publications87

  1. Belting M, Ahamed J, Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol. 2005;25:1545-50 pubmed
    ..Advanced cancer is associated with a hypercoagulable state, and tissue factor expression by cancer cells has received widespread attention because of its significant contribution to the ..
  2. Egorina E, Sovershaev M, Olsen J, Østerud B. Granulocytes do not express but acquire monocyte-derived tissue factor in whole blood: evidence for a direct transfer. Blood. 2008;111:1208-16 pubmed
    Unlike unanimous opinion on tissue factor (TF) expression in monocytes, the quest for TF presence in granulocytes has been going on for decades...
  3. Bogdanov V, Balasubramanian V, Hathcock J, Vele O, Lieb M, Nemerson Y. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med. 2003;9:458-62 pubmed
    b>Tissue factor (TF) is an essential enzyme activator that forms a catalytic complex with FVII(a) and initiates coagulation by activating FIX and FX, ultimately resulting in thrombin formation...
  4. Muller I, Klocke A, Alex M, Kotzsch M, Luther T, Morgenstern E, et al. Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets. FASEB J. 2003;17:476-8 pubmed
    Although tissue factor (TF), the principial initiator of physiological coagulation and pathological thrombosis, has recently been proposed to be present in human blood, the functional significance and location of the intravascular TF is ..
  5. Siddiqui F, Desai H, Amirkhosravi A, Amaya M, Francis J. The presence and release of tissue factor from human platelets. Platelets. 2002;13:247-53 pubmed
    b>Tissue factor (TF) is a transmembrane receptor for FVII that triggers blood coagulation. It is not normally exposed to circulating blood, but may be produced by endothelium and monocytes under pathological conditions...
  6. Stephens A, Ranlall N, Rivers R. Suppression of HUVEC tissue factor synthesis by antisense oligodeoxynucleotide. Thromb Res. 2008;122:99-107 pubmed
    b>Tissue factor (TF) is an important regulator and effector molecule of coagulation...
  7. Murata K, Higuchi T, Takada K, Oida K, Horie S, Ishii H. Verotoxin-1 stimulation of macrophage-like THP-1 cells up-regulates tissue factor expression through activation of c-Yes tyrosine kinase: Possible signal transduction in tissue factor up-regulation. Biochim Biophys Acta. 2006;1762:835-43 pubmed
    ..Shiga toxin) stimulation of macrophage-like THP-1 cells up-regulates the activity, antigen and mRNA levels of tissue factor (TF), a key cofactor of the coagulation-inflammation-thrombosis circuit...
  8. Østerud B. Tissue factor expression in blood cells. Thromb Res. 2010;125 Suppl 1:S31-4 pubmed publisher
    ..It may be concluded that monocytes are the only blood cells that synthesize and express TF and which may be the only source for TF-induced thrombosis when the endothelium is intact. ..
  9. Redecha P, Tilley R, Tencati M, Salmon J, Kirchhofer D, Mackman N, et al. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood. 2007;110:2423-31 pubmed
    ..In this study, we analyzed the role of the procoagulant molecule tissue factor (TF) in a mouse model of aPL antibody-induced pregnancy loss...
  10. Disse J, Petersen H, Larsen K, Persson E, ESMON N, Esmon C, et al. The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem. 2011;286:5756-67 pubmed publisher
    ..Here we show that soluble EPCR regulates the interaction of FX with human or mouse tissue factor (TF)-FVIIa complexes...
  11. Biro E, Sturk Maquelin K, Vogel G, Meuleman D, Smit M, Hack C, et al. Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner. J Thromb Haemost. 2003;1:2561-8 pubmed
    ..Their numbers, cellular source, and tissue factor (TF) exposure were determined using flow cytometry...
  12. Panes O, Matus V, Saez C, Quiroga T, Pereira J, Mezzano D. Human platelets synthesize and express functional tissue factor. Blood. 2007;109:5242-50 pubmed
    The source and significance of bloodborne tissue factor (TF) are controversial. TF mRNA, protein, and TF-dependent procoagulant activity (PCA) have been detected in human platelets, but direct evidence of TF synthesis is missing...
  13. Butenas S, Bouchard B, Brummel Ziedins K, Parhami Seren B, Mann K. Tissue factor activity in whole blood. Blood. 2005;105:2764-70 pubmed
    b>Tissue factor (TF) is an integral membrane protein essential for hemostasis...
  14. Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol. 2004;24:1015-22 pubmed
    b>Tissue factor (TF) is best known as the primary cellular initiator of blood coagulation. After vessel injury, the TF:FVIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets...
  15. Carlsson K, Freskgård P, Persson E, Carlsson U, Svensson M. Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor. Eur J Biochem. 2003;270:2576-82 pubmed
    Blood coagulation is triggered by the formation of a complex between factor VIIa (FVIIa) and its cofactor, tissue factor (TF)...
  16. Teng Y, Lin Q, Lin J, Ding C, Zuo Y. Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts. J Perinat Med. 2009;37:343-8 pubmed publisher
    ..and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies...
  17. de Gaetano M, Quacquaruccio G, Pezzini A, Latella M, Di Castelnuovo A, Del Zotto E, et al. Tissue factor gene polymorphisms and haplotypes and the risk of ischemic vascular events: four studies and a meta-analysis. J Thromb Haemost. 2009;7:1465-71 pubmed publisher
    The exposure of tissue factor (TF) to blood flow is the initial step in the coagulation process and plays an important role in thrombogenesis...
  18. Zhang X, Yu H, Lou J, Zheng J, Zhu H, Popescu N, et al. MicroRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem. 2011;286:1429-35 pubmed publisher
    b>Tissue factor has been recognized as a regulator of tumor angiogenesis and metastasis...
  19. Kambas K, Chrysanthopoulou A, Kourtzelis I, Skordala M, Mitroulis I, Rafail S, et al. Endothelin-1 signaling promotes fibrosis in vitro in a bronchopulmonary dysplasia model by activating the extrinsic coagulation cascade. J Immunol. 2011;186:6568-75 pubmed publisher
    ..We observed a higher number of neutrophils expressing tissue factor (TF) in bronchoalveolar lavage fluid (BALF) from infants with BPD than from those with uncomplicated ..
  20. Presta L, Sims P, Meng Y, Moran P, Bullens S, Bunting S, et al. Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic. Thromb Haemost. 2001;85:379-89 pubmed
    Blocking the cofactor function of human tissue factor may be beneficial in various coagulation-mediated diseases...
  21. Drake T, Morrissey J, Edgington T. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol. 1989;134:1087-97 pubmed
    b>Tissue factor (TF), the primary cellular initiator of the coagulation protease cascade, is implicated in having important roles in hemostasis, thrombogenesis, inflammation, and the cellular immune response, although the cytologic ..
  22. Broze G. Tissue factor pathway inhibitor and the revised theory of coagulation. Annu Rev Med. 1995;46:103-12 pubmed
    b>Tissue factor pathway inhibitor (TFPI) is a multivalent, Kunitz-type plasma proteinase inhibitor that regulates tissue factor-induced coagulation...
  23. Morrissey J, Fakhrai H, Edgington T. Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade. Cell. 1987;50:129-35 pubmed
    We have isolated cDNA clones encoding the complete sequence of the heavy chain of tissue factor (TF), the high-affinity receptor responsible for cellular initiation of the coagulation protease cascade...
  24. Spicer E, Horton R, Bloem L, Bach R, Williams K, Guha A, et al. Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA. Proc Natl Acad Sci U S A. 1987;84:5148-52 pubmed
    b>Tissue factor is a membrane-bound procoagulant protein that activates the extrinsic pathway of blood coagulation in the presence of factor VII and calcium...
  25. Banner D, D Arcy A, Chene C, Winkler F, Guha A, Konigsberg W, et al. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature. 1996;380:41-6 pubmed
    Blood coagulation is initiated when tissue factor binds to coagulation factor VIIa to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation...
  26. Zioncheck T, Roy S, Vehar G. The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism. J Biol Chem. 1992;267:3561-4 pubmed
    b>Tissue factor (TF) is an integral membrane glycoprotein that serves as a cellular receptor and cofactor for the activation of the plasma protease factor VII...
  27. Muller Y, Ultsch M, de Vos A. The crystal structure of the extracellular domain of human tissue factor refined to 1.7 A resolution. J Mol Biol. 1996;256:144-59 pubmed
    Exposure of blood to cells expressing tissue factor results in formation of a high-affinity complex with factor VIIa, initiating the extrinsic pathway of blood coagulation by the activation of factors IX and X...
  28. Toomey J, Kratzer K, Lasky N, Broze G. Effect of tissue factor deficiency on mouse and tumor development. Proc Natl Acad Sci U S A. 1997;94:6922-6 pubmed
    Previous reports suggest that tissue factor (TF) may play an essential role in embryonic vascular development and tumor angiogenesis...
  29. Funderburg N, Mayne E, Sieg S, Asaad R, Jiang W, Kalinowska M, et al. Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation. Blood. 2010;115:161-7 pubmed publisher
    ..elevated risk for coagulation may be related to increased proportions of monocytes expressing cell surface tissue factor (TF, thromboplastin) in persons with HIV infection...
  30. Nitori N, Ino Y, Nakanishi Y, Yamada T, Honda K, Yanagihara K, et al. Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clin Cancer Res. 2005;11:2531-9 pubmed
    b>Tissue factor (TF) is a transmembrane glycoprotein that plays roles in the blood coagulation and intracellular signaling pathways, and has also been suggested to modulate the biological behavior of cancer cells...
  31. McCormick M, Manduchi E, Witschey W, Gorman R, Gorman J, Jiang Y, et al. Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome. J Am Heart Assoc. 2016;5:e003170 pubmed publisher
    ..and oxidative phosphorylation were also consistently upregulated in the left ventricular apex, as were tissue factor pathway inhibitor (mean 50-fold) and prostacyclin synthase (5-fold)-genes prominently associated with ..
  32. Johansson Ã, Alfredsson J, Eriksson N, Wallentin L, Siegbahn A. Genome-Wide Association Study Identifies That the ABO Blood Group System Influences Interleukin-10 Levels and the Risk of Clinical Events in Patients with Acute Coronary Syndrome. PLoS ONE. 2015;10:e0142518 pubmed publisher
    ..2 × 10-13), and soluble tissue factor (sTF, P = 8.6 × 10-4) were also found...
  33. Chung J, Koyama T, Ohsawa M, Shibamiya A, Hoshi A, Hirosawa S. 1,25(OH)(2)D(3) blocks TNF-induced monocytic tissue factor expression by inhibition of transcription factors AP-1 and NF-kappaB. Lab Invest. 2007;87:540-7 pubmed
    An essential coagulation factor, tissue factor (TF), is rapidly expressed by human monocytes when exposed to a variety of agonists, such as lipopolysaccharide or tumor necrosis factor (TNF)...
  34. Okuyama N, Matsuda S, Yamashita A, Moriguchi Goto S, Sameshima N, Iwakiri T, et al. Human coronary thrombus formation is associated with degree of plaque disruption and expression of tissue factor and hexokinase II. Circ J. 2015;79:2430-8 pubmed publisher
    ..Thrombus size, ratio of thrombus to lumen area, length of plaque disruption, and immunopositive areas for tissue factor (TF) and hexokinase (HK)-II were significantly larger in coronary arteries with AMI than with asymptomatic ..
  35. Hobbs J, Zakarija A, Cundiff D, Doll J, Hymen E, Cornwell M, et al. Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. Thromb Res. 2007;120 Suppl 2:S13-21 pubmed
    b>Tissue Factor (TF) expression is observed in many types of cancer, associated with more aggressive disease, and thrombosis. Alternatively-spliced human tissue factor (asHTF) has recently been identified in which exon 5 is deleted...
  36. Han X, Zha H, Yang F, Guo B, Zhu B. Tumor-Derived Tissue Factor Aberrantly Activates Complement and Facilitates Lung Tumor Progression via Recruitment of Myeloid-Derived Suppressor Cells. Int J Mol Sci. 2017;18: pubmed publisher
    The initiator of extrinsic coagulation, tissue factor (TF), and its non-coagulant isoform alternatively spliced TF (asTF) are closely associated with tumor development...
  37. Grootendorst van Mil N, Tiemeier H, Steenweg de Graaff J, Jaddoe V, Steegers E, Steegers Theunissen R. Maternal Midpregnancy Plasma trans 18:1 Fatty Acid Concentrations Are Positively Associated with Risk of Maternal Vascular Complications and Child Low Birth Weight. J Nutr. 2017;147:398-403 pubmed publisher
    ..plasma t18:1 concentrations with birth weight in birth cohorts given the Dutch industry-initiative to lower food TFA contents during the inclusion period...
  38. Zhang Y, Yang J, Lv S, Zhao D, Chen Z, Li W, et al. Downregulation of decidual SP1 and P300 is associated with severe preeclampsia. J Mol Endocrinol. 2018;60:133-143 pubmed publisher
    ..SP1 is also very important for decidualization as it enhances the expression of tissue factor. In this study, we investigated the expression of SP1 and P300 in deciduae and their relationship with PE...
  39. Suresh Kumar A, Prabhakar Reddy T, Madhavachary R, Ramachary D. Rawal's catalyst as an effective stimulant for the highly asymmetric Michael addition of β-keto esters to functionally rich nitro-olefins. Org Biomol Chem. 2016;14:5494-9 pubmed publisher
    ..group engaged sequential Michael/amination/dehydration reactions on (E)-2-(2-nitrovinyl)anilines with cyclic and acyclic β-keto esters in the presence of a catalytic amount of Rawal's quinidine-NH-benzyl squaramide followed by TFA.
  40. De Palma R, Cirillo P, Ciccarelli G, Barra G, Conte S, Pellegrino G, et al. Expression of functional tissue factor in activated T-lymphocytes in vitro and in vivo: A possible contribution of immunity to thrombosis?. Int J Cardiol. 2016;218:188-195 pubmed publisher
    ..however, it is not known whether T-cells may contribute directly to thrombosis by expressing functional tissue factor (TF)...
  41. Peshkova A, Le Minh G, Tutwiler V, Andrianova I, Weisel J, Litvinov R. Activated Monocytes Enhance Platelet-Driven Contraction of Blood Clots via Tissue Factor Expression. Sci Rep. 2017;7:5149 pubmed publisher
    ..Inhibition of tissue factor expression or its inactivation on the surface of PMA-treated monocytes reduced the extent and rate of clot ..
  42. Curnow J. The Overall Hemostatic Potential (OHP) Assay. Methods Mol Biol. 2017;1646:523-531 pubmed publisher
    ..by optical density readings, which represent the balance between fibrin generation, triggered by thrombin or tissue factor, and fibrinolysis, triggered by tissue plasminogen activator (tPA)...
  43. Witkowski M, Tabaraie T, Steffens D, Friebel J, Dörner A, Skurk C, et al. MicroRNA-19a contributes to the epigenetic regulation of tissue factor in diabetes. Cardiovasc Diabetol. 2018;17:34 pubmed publisher
    ..In particular, hyperglycaemia and inflammatory cytokines induce vascular circulating tissue factor (TF) that promotes pro-thrombotic conditions in diabetes...
  44. Diamond S. Tissue factor activity under flow. Thromb Res. 2010;125 Suppl 1:S29-30 pubmed publisher
    ..Using controlled in vitro perfusions of whole blood, it is possible to determine the critical level of surface tissue factor needed to trigger full scale coagulation on collagen...
  45. Smith S, Comp P, Morrissey J. Traces of factor VIIa modulate thromboplastin sensitivity to factors V, VII, X, and prothrombin. J Thromb Haemost. 2006;4:1553-8 pubmed
    ..Thromboplastins made from purified, recombinant tissue factor are generally more sensitive to changes in plasma factor (F) VII levels than are thromboplastins prepared from ..
  46. Kothari H, Pendurthi U, Rao L. Analysis of tissue factor expression in various cell model systems: cryptic vs. active. J Thromb Haemost. 2013;11:1353-63 pubmed publisher
    b>Tissue factor (TF) encryption plays an important role in regulating TF coagulant activity. Potential differences in experimental cell model systems and strategies hampered our understanding of the TF encryption mechanisms...
  47. Wiiger M, Prydz H. The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells. Thromb Haemost. 2004;92:13-22 pubmed
    Binding of the coagulation protease factor VIIa to its receptor Tissue Factor (TF) induces intracellular signals in several cell types including HaCaT keratinocytes...
  48. Broussas M, Cornillet Lefebvre P, Potron G, Nguyen P. Adenosine inhibits tissue factor expression by LPS-stimulated human monocytes: involvement of the A3 adenosine receptor. Thromb Haemost. 2002;88:123-30 pubmed
    b>Tissue Factor (TF), an integral membrane glycoprotein that initiates the extrinsic pathway of blood coagulation, is thought to play a major part in coronary acute events...
  49. He S, Zhang J, Li N, Zhou S, Yue B, Zhang M. A TFPI-1 peptide that induces degradation of bacterial nucleic acids, and inhibits bacterial and viral infection in half-smooth tongue sole, Cynoglossus semilaevis. Fish Shellfish Immunol. 2017;60:466-473 pubmed publisher
    b>Tissue factor pathway inhibitor 1 (TFPI-1) is a serine protease inhibitor that inhibits tissue factor (TF)-mediated coagulation...
  50. Benagiano M, Gerosa M, Romagnoli J, Mahler M, Borghi M, Grassi A, et al. ?2 Glycoprotein I Recognition Drives Th1 Inflammation in Atherosclerotic Plaques of Patients with Primary Antiphospholipid Syndrome. J Immunol. 2017;198:2640-2648 pubmed publisher
    ..We also examined the helper function of ?2GPI-specific T cells for monocyte matrix metalloproteinase-9 and tissue factor production, as well as their cytolytic potential and their helper function for Ab production...
  51. Matijevic N, Wang Y, Wade C, Holcomb J, Cotton B, Schreiber M, et al. Cellular microparticle and thrombogram phenotypes in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study: correlation with coagulopathy. Thromb Res. 2014;134:652-8 pubmed publisher
    ..by flow cytometry for MP phenotypes [platelet (PMP), erythrocyte (RMP), leukocyte (LMP), endothelial (EMP), tissue factor (TFMP), and Annexin V positive (AVMP)]. 21...
  52. Ramsden C, Hibbeln J, Majchrzak S, Davis J. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr. 2010;104:1586-600 pubmed publisher
    ..diets on relevant CHD outcomes in meta-analyses; (4) evaluated the potential confounding role of trans-fatty acids (TFA)...
  53. van den Besselaar A, Chantarangkul V, Tripodi A. Thromboplastin standards. Biologicals. 2010;38:430-6 pubmed publisher
    ..In addition to monitoring of VKA, the PT is used for management of patients with chronic liver disease. Likewise, INR(liver) should be based on calibration with an IS using samples from patients with chronic liver disease. ..
  54. Panasiuk A, Zak J, Panasiuk B, Prokopowicz D. Increase in expression of monocytic tissue factor (CD142) with monocytes and blood platelet activation in liver cirrhosis. Blood Coagul Fibrinolysis. 2007;18:739-44 pubmed
    b>Tissue factor (TF) is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of TF, and while accumulating in the organ they can intensify inflammation...
  55. Chung J, Suzuki H, Tabuchi N, Sato K, Shibamiya A, Koyama T. Identification of tissue factor and platelet-derived particles on leukocytes during cardiopulmonary bypass by flow cytometry and immunoelectron microscopy. Thromb Haemost. 2007;98:368-74 pubmed
    The extrinsic coagulation system initiated by tissue factor (TF) appears to be a major procoagulant stimulus during cardiopulmonary bypass (CPB), although the precise mechanisms remain to be revealed...
  56. Wu Z, Wang T, Meng Y, Rao Y, Wang B, Zheng J, et al. Enhancing the reactivity of nickel(ii) in hydrogen evolution reactions (HERs) by ?-hydrogenation of porphyrinoid ligands. Chem Sci. 2017;8:5953-5961 pubmed publisher
    ..Ni(ii) hydroporpholactone (Ni-4) and porpholactone (Ni-3), respectively) using trifluoroacetic acid (TFA) as the proton source...
  57. Labrecque L, Rahimaly K, Imhoff S, Paquette M, Le Blanc O, Malenfant S, et al. Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness. Physiol Rep. 2017;5: pubmed publisher
    ..and rate of regulation, after transient hypotension induced by sit-to-stand, and transfer function analysis (TFA) of MAP and MCAv responses during (2) spontaneous and (3) forced oscillations (5-min of squat-stand maneuvers ..
  58. Chan S, Lian Q, Chen M, Jiang D, Ho J, Cheung Y, et al. Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis. Toxicol Appl Pharmacol. 2018;338:148-158 pubmed publisher
    ..A significant increase in apoptotic cells and EMPs were found under iron treatment. EMPs contained tissue factor (TF), which has potential clinical impact on thromboembolic phenomenon...
  59. Herklotz M, Hanke J, Hänsel S, Drichel J, Marx M, Maitz M, et al. Biomaterials trigger endothelial cell activation when co-incubated with human whole blood. Biomaterials. 2016;104:258-68 pubmed publisher
    ..Analysis of intracellular levels of the endothelial activation markers E-selectin and tissue factor showed that co-incubation with model surfaces and blood significantly increased the activation state of ECs...
  60. Vlotides G, Gaertner R, Angstwurm M. Modulation of monocytic lipopolysaccharide-induced tissue factor expression and tumor necrosis factor alpha release by estrogen and calcitriol. Hormones (Athens). 2007;6:52-61 pubmed
    ..Monocyte-derived tissue factor (TF) expression can activate the coagulation system and worsen the course of severe infection...
  61. Zhu S, Travers R, Morrissey J, Diamond S. FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow. Blood. 2015;126:1494-502 pubmed publisher
    ..The significance of these mediators in human blood under thrombotic flow conditions on tissue factor (TF) -bearing surfaces remains inadequately resolved...
  62. Thaler J, Koppensteiner R, Pabinger I, Ay C, Gremmel T. Microparticle-associated tissue factor activity in patients with acute unprovoked deep vein thrombosis and during the course of one year. Thromb Res. 2014;134:1093-6 pubmed publisher
    b>Tissue factor (TF) is the main in-vivo initiator of blood coagulation. Microparticles (MPs) are small procoagulant membrane vesicles...
  63. Steppich B, Hassenpflug M, Braun S, Schömig K, von Beckerath O, von Beckerath N, et al. Circulating tissue factor and microparticles are not increased in patients with deep vein thrombosis. Vasa. 2011;40:117-22 pubmed publisher
    Circulating tissue factor (TF) is associated with inflammation and may contribute to thrombotic events. Aim of this study was to analyze circulating TF activity and proinflammatory cytokines in patients with deep venous thrombosis...
  64. Yu G, Li H, Wang X, Wu T, Zhu J, Huang S, et al. MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion. Mol Cell Biochem. 2013;380:239-47 pubmed publisher
    The over-expression of tissue factor (TF) and its roles in colon cancer progression have attracted much attention. However, the mechanisms regulating TF expression have not yet been shown in detail...
  65. Holy E, Tanner F. Tissue factor in cardiovascular disease pathophysiology and pharmacological intervention. Adv Pharmacol. 2010;59:259-92 pubmed publisher
    b>Tissue factor (TF) is the major trigger of the coagulation cascade and thereby crucially involved in the maintenance of vascular hemostasis...
  66. Bluff J, Amarzguioui M, Slattery J, Reed M, Brown N, Staton C. Anti-tissue factor short hairpin RNA inhibits breast cancer growth in vivo. Breast Cancer Res Treat. 2011;128:691-701 pubmed publisher
    In breast cancer, there is a correlation between tissue factor (TF) expression, angiogenesis and disease progression. TF stimulates tumour angiogenesis, in part, through up-regulation of vascular endothelial growth factor (VEGF)...
  67. Wiiger M, Prydz H. The changing faces of tissue factor biology. A personal tribute to the understanding of the "extrinsic coagulation activation". Thromb Haemost. 2007;98:38-42 pubmed
  68. Giansily Blaizot M, Schved J. Recombinant human factor VIIa (rFVIIa) in hemophilia: mode of action and evidence to date. Ther Adv Hematol. 2017;8:345-352 pubmed publisher
    ..normal physiology of factor VII/ factor VIIa (FVII/FVIIa) in the hemostatic process requires the presence of tissue factor (TF) that links to FVII leading to a FVIIa-TF complex which activates both factor X and factor IX...
  69. Hu H, Chen X, Wang C, Jiang Y, Li J, Ying X, et al. The role of TFPI2 hypermethylation in the detection of gastric and colorectal cancer. Oncotarget. 2017;8:84054-84065 pubmed publisher
    Gastrointestinal cancer is a prevalent disease with high morbidity and mortality. Tissue factor pathway inhibitor 2 (TFPI2) gene could protect the extracellular matrix of cancer cells from degradation and tumor invasion...
  70. Yokota N, Koizume S, Miyagi E, Hirahara F, Nakamura Y, Kikuchi K, et al. Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells. Br J Cancer. 2009;101:2023-9 pubmed publisher
    Thromboembolic events are a major complication in ovarian cancer patients. Tissue factor (TF) is frequently overexpressed in ovarian cancer tissue and correlates with intravascular thrombosis...
  71. Song H, Park K, Kim J, Kim D, Yu Y, Kim J. Tissue factor regulates tumor angiogenesis of retinoblastoma via the extracellular signal-regulated kinase pathway. Oncol Rep. 2012;28:2057-62 pubmed publisher
  72. John A, Gorzelanny C, Bauer A, Schneider S, Bolenz C. Role of the Coagulation System in Genitourinary Cancers: Review. Clin Genitourin Cancer. 2017;: pubmed publisher
    ..An elevated expression of procoagulatory tissue factor on tumor cells and tumor-derived microparticles seems to stimulate cancer development and progression...
  73. Barska K, Kwiatkowska W, Knysz B, Arczyńska K, Karczewski M, Witkiewicz W. The role of the tissue factor and its inhibitor in the development of subclinical atherosclerosis in people living with HIV. PLoS ONE. 2017;12:e0181533 pubmed publisher
    ..in the general population emphasize the role of the extrinsic pathway of blood coagulation, particularly the tissue factor (TF) and tissue factor pathway inhibitor (TFPI)...
  74. Zhang Z, Gillespie C, Yang Q. Plasma trans-fatty acid concentrations continue to be associated with metabolic syndrome among US adults after reductions in trans-fatty acid intake. Nutr Res. 2017;43:51-59 pubmed publisher
    ..between intake of trans-fatty acids (TFAs) and risk of metabolic syndrome before and after significant reduction of TFA intakes in the US population...
  75. Mackman N. Alternatively spliced tissue factor - one cut too many?. Thromb Haemost. 2007;97:5-8 pubmed
  76. Naji A, Deschaseaux F, Racadot E, Ferrand C, Justrabo E, Guignier F, et al. Induction of tissue factor expression on human umbilical vein endothelial cells by cell-specific HLA class I antibody: preliminary data. Transplant Proc. 2005;37:2892-3 pubmed
    ..The aim of this study was to examine whether donor-specific HLA antibodies induce overexpression of tissue factor (TF) by endothelial cells...
  77. McGilvray I, Tsai V, Marshall J, Dackiw A, Rotstein O. Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases. Shock. 2002;18:51-7 pubmed
    The expression of tissue factor (TF) by monocytes that have transmigrated across the endothelium to sites of extravascular inflammation acts both to focus and amplify the inflammatory response...
  78. Saito Y, Goto M, Maya K, Ogawa N, Fujimori K, Kurokawa Y, et al. The influence of brain death on tissue factor expression in the pancreatic tissues and isolated islets in rats. Transplant Proc. 2009;41:307-10 pubmed publisher
    b>Tissue factor (TF) in islets has been identified as the main trigger of the instant blood-mediated inflammatory reaction...