Gene Symbol: TIRAP
Description: TIR domain containing adaptor protein
Alias: BACTS1, Mal, MyD88-2, wyatt, toll/interleukin-1 receptor domain-containing adapter protein, MyD88 adapter-like protein, Toll-like receptor adaptor protein, adapter protein wyatt, adaptor protein Wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Species: human
Products:     TIRAP

Top Publications

  1. Hamann L, Kumpf O, Schuring R, Alpsoy E, Bedu Addo G, Bienzle U, et al. Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. BMC Med Genet. 2009;10:65 pubmed publisher
    ..A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous ..
  2. Shinobu N, Iwamura T, Yoneyama M, Yamaguchi K, Suhara W, Fukuhara Y, et al. Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide. FEBS Lett. 2002;517:251-6 pubmed
    ..Notably, our investigation revealed a critical function for TIRAP/MAL, a signaling adapter for Toll-like receptor (TLR) 4, in LPS-induced but not dsRNA-induced activation of IRF-3...
  3. Bin L, Xu L, Shu H. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem. 2003;278:24526-32 pubmed
    ..Our findings suggest that TIRP is involved in IL-1-triggered NF-kappaB activation and functions upstream of IRAK, IRAK-2, TRAF6, and IKKbeta ..
  4. Hawn T, Dunstan S, Thwaites G, Simmons C, Thuong N, Lan N, et al. A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. J Infect Dis. 2006;194:1127-1134 pubmed publisher
    ..We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with ..
  5. Nejentsev S, Thye T, Szeszko J, Stevens H, Balabanova Y, Chinbuah A, et al. Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations. Nat Genet. 2008;40:261-2; author reply 262-3 pubmed publisher
  6. Fitzgerald K, Rowe D, Barnes B, Caffrey D, Visintin A, Latz E, et al. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003;198:1043-55 pubmed
    ..TRAM interacts with TRIF, MyD88 adaptor-like protein (Mal)/TIRAP, and TLR4 but not with TLR3...
  7. Castiblanco J, Varela D, Castano Rodriguez N, Rojas Villarraga A, Hincapie M, Anaya J. TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. Infect Genet Evol. 2008;8:541-4 pubmed publisher
    ..The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in the TLR2- and TLR4-mediated MyD88-dependent signaling pathway...
  8. Ramasawmy R, Cunha Neto E, Fae K, Borba S, Teixeira P, Ferreira S, et al. Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy. J Infect Dis. 2009;199:1838-45 pubmed publisher
    ..reaction-restriction fragment length polymorphism analysis for the genes TLR1, TLR2, TLR4, TLR5, TLR9, and MAL/TIRAP, which encodes an adaptor protein...
  9. Horng T, Barton G, Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol. 2001;2:835-41 pubmed
    ..We have identified and characterized a Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) and have shown that it controls activation of MyD88-independent signaling pathways downstream of TLR4...

More Information

Publications114 found, 100 shown here

  1. Ferwerda B, Alonso S, Banahan K, McCall M, Giamarellos Bourboulis E, Ramakers B, et al. Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A. 2009;106:10272-7 pubmed publisher
    ..Recently, a polymorphism in Mal (Ser180Leu, TIRAP rs8177374), an important adaptor protein downstream of the Toll-like receptor (TLR) 2 and 4 pathways, has been ..
  2. Hawn T, Scholes D, Li S, Wang H, Yang Y, Roberts P, et al. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS ONE. 2009;4:e5990 pubmed publisher
    ..Although these data suggest that TLR polymorphisms are associated with adult susceptibility to UTIs, the statistical significance was modest and will require further study including validation with independent cohorts. ..
  3. Chaudhary A, Ganguly K, Cabantous S, Waldo G, Micheva Viteva S, Nag K, et al. The Brucella TIR-like protein TcpB interacts with the death domain of MyD88. Biochem Biophys Res Commun. 2012;417:299-304 pubmed publisher
    ..directly with MyD88 and that this interaction is significantly stronger than the interaction of TcpB with TIRAP, the only other adaptor protein that detectably interacts with TcpB...
  4. Fitzgerald K, Palsson McDermott E, Bowie A, Jefferies C, Mansell A, Brady G, et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001;413:78-83 pubmed
    ..Here we describe a protein, Mal (MyD88-adapter-like), which joins MyD88 as a cytoplasmic TIR-domain-containing protein in the human genome...
  5. Horng T, Barton G, Flavell R, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 2002;420:329-33 pubmed
    ..b>TIRAP, an adaptor protein in the TLR signalling pathway, has been identified and shown to function downstream of TLR4 (..
  6. Jeyaseelan S, Manzer R, Young S, Yamamoto M, Akira S, Mason R, et al. Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli. J Immunol. 2005;175:7484-95 pubmed
    ..Toll-IL-1R domain-containing adaptor protein (TIRAP) is a key molecule in the TLR4 and 2 signaling...
  7. Kagan J, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 2006;125:943-55 pubmed
    ..Signaling downstream from TLRs is initiated by the recruitment of adaptor proteins, including MyD88 and TIRAP. These adaptors play essential roles in TLR signaling, but the mechanism of their function is currently unknown...
  8. Khor C, Chapman S, Vannberg F, Dunne A, Murphy C, Ling E, et al. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet. 2007;39:523-8 pubmed
    ..The adaptor protein Mal (also known as TIRAP), encoded by TIRAP (MIM 606252), mediates downstream signaling of TLR2 and TLR4 (refs. 4-6)...
  9. Nishiya T, Kajita E, Horinouchi T, Nishimoto A, Miwa S. Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88. FEBS Lett. 2007;581:3223-9 pubmed
    ..These findings reveal distinct roles for the TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88. ..
  10. Piao W, Song C, Chen H, Wahl L, Fitzgerald K, O Neill L, et al. Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance. J Biol Chem. 2008;283:3109-19 pubmed
    ..g. MyD88 adapter-like (Mal)) and signaling (e.g...
  11. Biswas S, Zimman A, Gao D, Byzova T, Podrez E. TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated With Hyperlipidemia. Circ Res. 2017;121:951-962 pubmed publisher
    ..oxPCCD36 induce formation of CD36/TLR2/TLR6 complex in platelets and activate downstream signaling via TIRAP (Toll-interleukin 1 receptor domain containing adaptor protein)-MyD88-IRAK (interleukin-1 receptor-associated ..
  12. Ippagunta S, Pollock J, Sharma N, Lin W, Chen T, Tawaratsumida K, et al. Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Sci Signal. 2018;11: pubmed publisher
    ..initiated by Toll/interleukin-1 receptor homology domains (TIR) found in TLRs and the cytoplasmic adaptor proteins TIRAP and MyD88...
  13. Baig M, Liu D, Muthu K, Roy A, Saqib U, Naim A, et al. Heterotrimeric complex of p38 MAPK, PKCδ, and TIRAP is required for AP1 mediated inflammatory response. Int Immunopharmacol. 2017;48:211-218 pubmed publisher
    ..of Protein kinase C delta type (PKCδ), Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP), and p38 proteins. TIRAP serves as an adaptor molecule which brings PKCδ and p38 in close proximity...
  14. Lu D, Wang W, Xia L, Xia P, Yan Y. Gene expression profiling reveals heterogeneity of perivascular adipose tissues surrounding coronary and internal thoracic arteries. Acta Biochim Biophys Sin (Shanghai). 2017;:1-8 pubmed publisher
    ..interleukin-6 (IL-6), Toll-like receptor 2 (TLR2), Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), serum amyloid A2 (SAA2), and Leptin were validated by real-time PCR analysis...
  15. Wang P, Liu B, Wu M, Wei X, Sheng S, You S, et al. Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats. Neurosci Lett. 2019;699:77-83 pubmed publisher
    ..As innate immunity plays crucial roles in CNS development, moderate PAE-induced suppression of TLR4-mediated response may serve as a new candidate mechanism of CNS developmental defects. ..
  16. Naghizadeh M, Baradaran B, Saghafi Asl M, Amiri P, Shanehbandi D, Karamzad N, et al. Toll-like receptor signaling and serum levels of interferon β and lipopolysaccharide binding protein are related to abdominal obesity: a case-control study between metabolically healthy and metabolically unhealthy obese individuals. Nutr Res. 2018;55:11-20 pubmed publisher
    ..50, P < .001) and serum IFNβ and LBP (r = 0.70, P < .001). It is concluded that the expression levels of TLR4 and TRIF as well as serum IFNβ and LBP are more related to abdominal obesity than to metabolic health. ..
  17. Jakka P, Namani S, Murugan S, Rai N, Radhakrishnan G. The Brucella effector protein TcpB induces degradation of inflammatory caspases and thereby subverts non-canonical inflammasome activation in macrophages. J Biol Chem. 2017;292:20613-20627 pubmed publisher
    ..Because TcpB suppresses both TLR4- and caspase-4/11-mediated inflammation, TcpB might be a candidate target for developing drugs against LPS-induced septicemia. ..
  18. Alaidarous M, Ve T, Casey L, Valkov E, Ericsson D, Ullah M, et al. Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB. J Biol Chem. 2014;289:654-68 pubmed publisher
    ..In this study, we show using co-immunoprecipitation analyses that TcpB interacts with MAL, MyD88, and TLR4 but interferes only with the MAL-TLR4 interaction...
  19. Di Stefano A, Ricciardolo F, Caramori G, Adcock I, Chung K, Barnes P, et al. Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression. Eur Respir J. 2017;49: pubmed publisher
    ..differentiation primary response gene 88 (MyD88), Toll-interleukin-1 receptor domain-containing adaptor protein (TIRAP), and the interleukin-1 receptor-associated kinases phospho-IRAK1 and IRAK4 were measured in the bronchial mucosa ..
  20. Yücel G, Zhao Z, El Battrawy I, Lan H, Lang S, Li X, et al. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes. Sci Rep. 2017;7:2935 pubmed publisher
    ..TLR4 (Toll-like receptor 4) and its associated proteins, CD14, LBP (lipopolysaccharide binding protein), TIRAP (toll-interleukin 1 receptor domain containing adaptor protein), Ly96 (lymphocyte antigen 96) and nuclear factor ..
  21. Schoffelen T, Ammerdorffer A, Hagenaars J, Bleeker Rovers C, Wegdam Blans M, Wever P, et al. Genetic Variation in Pattern Recognition Receptors and Adaptor Proteins Associated With Development of Chronic Q Fever. J Infect Dis. 2015;212:818-29 pubmed publisher
    ..primary response protein 88 (MyD88), and Toll interleukin 1 receptor domain-containing adaptor protein (TIRAP) were genotyped in 139 patients with chronic Q fever and in 220 controls with cardiovascular risk-factors and ..
  22. Liaunardy Jopeace A, Bryant C, Gay N. The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane. Sci Signal. 2014;7:ra70 pubmed publisher
  23. Nilsen N, Vladimer G, Stenvik J, Orning M, Zeid Kilani M, Bugge M, et al. A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling. J Biol Chem. 2015;290:3209-22 pubmed publisher
    ..TLR2 and TLR4 signal via the Toll/interleukin-1 receptor adaptors MyD88 and MAL, leading to NF-κB activation...
  24. Halabi S, Sekine E, Verstak B, Gay N, Moncrieffe M. Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome. J Biol Chem. 2017;292:652-660 pubmed publisher
    ..Dimeric BCAP associates with the TIR domains of TLR2/4 and MAL/TIRAP, suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions...
  25. Klouche K, Amigues L, Morena M, Brunot V, Dupuy A, Jaussent A, et al. On-line hemodiafiltration did not induce an overproduction of oxidative stress and inflammatory cytokines in intensive care unit-acute kidney injury. BMC Nephrol. 2017;18:371 pubmed publisher
    ..Intradialytic hypotensive events were observed during 27/203 OL-IHDF sessions accounting for a mal-tolerated session's rate at 13.3%. Mean delivered urea Kt/V per session was 1.12?±?0...
  26. Verrotti A, Castagnino M, Maccarrone M, Fezza F. Plant-Derived and Endogenous Cannabinoids in Epilepsy. Clin Drug Investig. 2016;36:331-40 pubmed publisher
    ..and could be effective in treating partial epilepsies and generalized tonic-clonic seizures, still known as "grand mal." They are based, among other factors, on the observation that in individuals who smoke marijuana to treat epilepsy,..
  27. Sijbrandi N, Merkul E, Muns J, Waalboer D, Adamzek K, Bolijn M, et al. A Novel Platinum(II)-Based Bifunctional ADC Linker Benchmarked Using 89Zr-Desferal and Auristatin F-Conjugated Trastuzumab. Cancer Res. 2017;77:257-267 pubmed publisher
    ..breast cancer (JIMT-1), a single dose of trastuzumab-Lx-AF outperformed its maleimide benchmark trastuzumab-Mal-AF and FDA-approved ado-trastuzumab emtansine...
  28. Rieger D, Dos Santos A, Suñol C, Farina M. Involvement of superoxide in malaoxon-induced toxicity in primary cultures of cortical neurons. J Toxicol Environ Health A. 2017;80:1106-1115 pubmed publisher
    ..the potential occurrence of oxidative stress as a critical step in the toxicity induced by the OP malaoxon(MAL) using primary cultures of mouse cortical neurons, as well as to distinguish MAL-induced oxidative stress and cell ..
  29. Walsh A, Sinclair V, Watmough P, Henderson A. Ankle fractures: Getting it right first time. Foot (Edinb). 2018;34:48-52 pubmed publisher
    ..three (23%) for complete failure of fixation, two (15%) with wound problems and one (8%) for medial malleolus mal-reduction. Of the patient group, five (39%) were known type 2 diabetics...
  30. Matalka K, Abdulridha N, Badr M, Mansoor K, Qinna N, Qadan F. Eriobotrya japonica Water Extract Characterization: An Inducer of Interferon-Gamma Production Mainly by the JAK-STAT Pathway. Molecules. 2016;21: pubmed publisher
    ..WP was then subjected to methanol:acetone fractionation, yielding upper (MAU) and lower (MAL) phases...
  31. Borjini N, Fernández M, Giardino L, Calzà L. Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. J Neuroinflammation. 2016;13:291 pubmed
    ..Myelin genes were down-regulated starting from 8 DPI, especially MAL, MBP, and PMP22 while an opposite expression profile was observed for inflammation-related genes, such as CXCL11 ..
  32. Houwing D, Buwalda B, Van der Zee E, de Boer S, Olivier J. The Serotonin Transporter and Early Life Stress: Translational Perspectives. Front Cell Neurosci. 2017;11:117 pubmed publisher
    ..However, underlying neuromolecular mechanisms of the (mal)adaptive responses to adversity displayed by SERT rodents remain to be elucidated...
  33. Kaldybekov D, Tonglairoum P, Opanasopit P, Khutoryanskiy V. Mucoadhesive maleimide-functionalised liposomes for drug delivery to urinary bladder. Eur J Pharm Sci. 2018;111:83-90 pubmed publisher
    ..In this work, maleimide-functionalised PEGylated liposomes (PEG-Mal) were explored as mucoadhesive vehicles for drug delivery to the urinary bladder...
  34. Farid S, AbuSaleh O, Liesman R, Sohail M. Isolated cerebral mucormycosis caused by Rhizomucor pusillus. BMJ Case Rep. 2017;2017: pubmed publisher
    ..stem cell transplant and multiple chemotherapy regimens presented to the emergency room after suffering a grand mal seizure. His evaluation revealed a 1.5-2?cm ring-enhancing left temporal lobe brain lesion on the CT scan...
  35. Sheehan F, Brainerd E, Troy K, Shefelbine S, Ronsky J. Advancing quantitative techniques to improve understanding of the skeletal structure-function relationship. J Neuroeng Rehabil. 2018;15:25 pubmed publisher
    ..along with the genesis of musculoskeletal pathologies, is quantifying how the human skeletal system adapts and mal-adapts to its mechanical environment...
  36. Girard C, Adamski H, Basset Seguin N, Beaulieu P, Dreno B, Riboulet J, et al. [Procedure for daylight methyl aminolevulinate photodynamic therapy to treat actinic keratoses]. Ann Dermatol Venereol. 2016;143:257-63 pubmed publisher
    ..In France, photodynamic therapy using red light (conventional PDT) and methylamino 5-levulinate (MAL) is indicated in the treatment of thin or non-hyperkeratotic and non-pigmented multiple AK lesions or large zones ..
  37. Brito C, Resende C, Oliveira P. A 10-Year Retrospective Analysis of Methyl Aminolevulinate Photodynamic Therapy Consultation at the Hospital de Braga. Dermatol Ther (Heidelb). 2016;6:265-72 pubmed publisher
    ..study was to describe the results of a retrospective analysis of patients treated with methyl aminolevulinate PDT (MAL-PDT) with red light, over the past decade at the Hospital de Braga (Braga, Portugal)...
  38. Cantisani C, Paolino G, Pellacani G, Didona D, Scarnò M, Faina V, et al. MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera. Int J Mol Sci. 2016;17: pubmed publisher
    ..The 3D imaging allowed for quantifying in real time the aesthetic benefits of DL-PDT's increasing compliance. ..
  39. Malash A, Ali A, Samy R, Shamma R. Association of TLR polymorphisms with bronchopulmonary dysplasia. Gene. 2016;592:23-28 pubmed publisher
    ..polymorphisms (SNPs) in TLR pathway genes [TLR5 and Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP)] among preterm neonates and to determine their association with the development and severity of bronchopulmonary ..
  40. Suárez Moreno R, Ponce Pérez L, Margain Paredes M, Garza de la Llave H, Madrazo Navarro M, Espinosa Álvarez A. [Churg-Strauss abdominal manifestation]. Cir Cir. 2014;82:183-7 pubmed
    ..Existen pocos reportes con este síndrome asociado con abdomen agudo, todos ellos con mal pronóstico.
  41. Saito S, Ueda M, Takahashi N, Kawakatsu M, Suzuki S. Three-dimensional ultrasonography for visualization of muscular anomalies in type VI and VII radial polydactyly. Skeletal Radiol. 2016;45:541-7 pubmed publisher
    ..The muscular abnormalities identified were mal-positions of the thenar muscles in a type VI case and a deficiency of the abductor pollicis brevis muscle in a type ..
  42. Elmalı N, TaÅŸdemir Z, SaÄŸlam F, Gülabi D, Baysal Ã. One-stage surgical treatment of neglected simultaneous bilateral locked posterior dislocation of shoulder: a case report and literature review. Eklem Hastalik Cerrahisi. 2015;26:175-80 pubmed publisher
    ..with an associated large impression fracture on the anteromedial aspect of both humeral heads after a grand mal type epileptic seizure...
  43. Blanco E, Guerra B, de la Torre B, Defaus S, Dekker A, Andreu D, et al. Full protection of swine against foot-and-mouth disease by a bivalent B-cell epitope dendrimer peptide. Antiviral Res. 2016;129:74-80 pubmed publisher
    ..bearing two copies of a B-cell epitope from a type O isolate and using thioether [B2T(thi)] or maleimide [B2T(mal)] conjugation chemistries for their synthesis elicited in swine similar or higher B and T-cell specific responses ..
  44. Sanclemente G, Ruiz Cañas V, Miranda J, Ferrín A, Ramirez P, Hernandez G. Photodynamic Therapy Interventions in Facial Photodamage: A Systematic Review. Actas Dermosifiliogr. 2018;109:218-229 pubmed publisher
    ..to inclusion criteria, twelve studies were included (6 aminolevulinate (ALA) trials and 6 methyl aminolevulinate (MAL) trials), but the majority of them had methodological constraints particularly in randomization description and ..
  45. Niklasch M, Klotz M, Wolf S, Dreher T. Long-term development of overcorrection after femoral derotation osteotomy in children with cerebral palsy. Gait Posture. 2018;61:183-187 pubmed publisher
    ..Preoperative predictors for long-term development couldn't be identified. If pelvic mal-rotation is corrected, hip rotation may change into normal range over the time in combination with the development ..
  46. Kapanda G, Muiruri C, Kulanga A, Tarimo C, Lisasi E, Mimano L, et al. Enhancing future acceptance of rural placement in Tanzania through peripheral hospital rotations for medical students. BMC Med Educ. 2016;16:51 pubmed publisher
    b>Mal-distribution of health care workers is a global health challenge that exacerbates health disparities, especially in resource-limited settings...
  47. Uijterwaal M, van Zummeren M, Kocken M, Luttmer R, Berkhof J, Witte B, et al. Performance of CADM1/MAL-methylation analysis for monitoring of women treated for high-grade CIN. Gynecol Oncol. 2016;143:135-142 pubmed publisher
    Recent studies have shown that CADM1/MAL-methylation testing detects high-grade CIN lesions with a high short-term progression risk for cervical cancer...
  48. Bhambani S, Phan T, Brown L, Thorp A. Replacement of Dislodged Gastrostomy Tubes After Stoma Dilation in the Pediatric Emergency Department. West J Emerg Med. 2017;18:770-774 pubmed publisher
    ..There was a single complication of a mal-positioned balloon that was identified at the index visit. No delayed complications were encountered...
  49. Yazdanyar S, Zarchi K, Jemec G. Pain during topical photodynamic therapy - comparing methyl aminolevulinate (Metvix®) to aminolaevulinic acid (Ameluz®); an intra-individual clinical study. Photodiagnosis Photodyn Ther. 2017;20:6-9 pubmed publisher
    ..pain response differ in treatment of actinic keratoses in scalp and forhead, using branded methyl aminolevulinate (MAL) and aminolaevulinic acid (ALA)...
  50. Ormond A, Freeman H. Dye Sensitizers for Photodynamic Therapy. Materials (Basel). 2013;6:817-840 pubmed publisher
    ..and precursors to endogenous protoporphyrin IX (PpIX): 1,5-aminolevulinic acid (ALA), methyl aminolevulinate (MAL), hexaminolevulinate (HAL)...
  51. Liang R, Li W, Wang H, Wang J, Niu Q. Impact of sub-chronic aluminium-maltolate exposure on catabolism of amyloid precursor protein in rats. Biomed Environ Sci. 2013;26:445-52 pubmed publisher
    To investigate the impact of sub-chronic Aluminium-maltolate [Al(mal)3] exposure on the catabolism of amyloid precursor protein (APP) in rats...
  52. Groussin M, Boussau B, Szöllõsi G, Eme L, Gouy M, Brochier Armanet C, et al. Gene Acquisitions from Bacteria at the Origins of Major Archaeal Clades Are Vastly Overestimated. Mol Biol Evol. 2016;33:305-10 pubmed publisher
    In a recent article, Nelson-Sathi et al. (NS) report that the origins of major archaeal lineages (MAL) correspond to massive group-specific gene acquisitions via HGT from bacteria (Nelson-Sathi et al. 2015...
  53. Manni R, De Icco R, Cremascoli R, Ferrera G, Furia F, Zambrelli E, et al. Circadian phase typing in idiopathic generalized epilepsy: Dim light melatonin onset and patterns of melatonin secretion-Semicurve findings in adult patients. Epilepsy Behav. 2016;61:132-137 pubmed publisher
    ..Twenty adults diagnosed with IGE (grand mal on awakening [GM] in 7 cases and juvenile myoclonic epilepsy in 13 cases) were investigated by means of a face-to-..
  54. Štarha P, Trávníček Z, Pazderová L, Dvořák Z. Platinum(II) carboxylato complexes containing 7-azaindoles as N-donor carrier ligands showed cytotoxicity against cancer cell lines. J Inorg Biochem. 2016;162:109-116 pubmed publisher
    The platinum(II) malonato (Mal) and decanoato (Dec) complexes of the general formulas [Pt(Mal)(naza)2] (1-3) and cis-[Pt(Dec)2(naza)2] (4-7) were prepared, characterized and tested for their in vitro ..
  55. Xiao M, Zhu X, Xu H, Tang J, Liu R, Bi C, et al. A novel point mutation in RpoB improves osmotolerance and succinic acid production in Escherichia coli. BMC Biotechnol. 2017;17:10 pubmed publisher
    ..Additional genetic experiments showed that enhancing the expression of the mal regulon, especially for genes that encode the glycoporin LamB and maltose transporter, contributed to the ..
  56. Kollewe C, Mackensen A, Neumann D, Knop J, Cao P, Li S, et al. Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. J Biol Chem. 2004;279:5227-36 pubmed
    ..Thus, IRAK-1 regulates its own availability as an adapter molecule by sequential autophosphorylation. ..
  57. Shi C, Cao H, He W, Gao F, Liu Y, Yin L. Novel drug delivery liposomes targeted with a fully human anti-VEGF165 monoclonal antibody show superior antitumor efficacy in vivo. Biomed Pharmacother. 2015;73:48-57 pubmed publisher
    ..The VEGF mAb was then conjugated to the Mal-PEG2000-DSPE liposome at a ratio of 6...
  58. Radin K, Clement F, Jongert E, Sterckx Y, Ockenhouse C, Regules J, et al. A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum. Malar J. 2016;15:543 pubmed
    ..antibody content were measured in 276 serum samples from RTS,S/AS01 vaccine recipients using the standard ELISA and MAL-1C competition ELISA, respectively. A strong correlation was observed between the results from these assays...
  59. Theka T, Rodgers A. Glycaemia and phosphatemia after oral glucose and maltitol ingestion in subjects from two different race groups: preliminary evidence of inter-race differences in metabolism and possible implications for urinary stone disease. Int Urol Nephrol. 2017;49:1369-1374 pubmed publisher
    Glucose (Glu) and maltitol (Mal) ingestion affect calciuria and phosphaturia. Renal phosphate leak involving hypophosphatemia is thought to be a mechanism. Inter-race differences in carbohydrate metabolism are known...
  60. Wang Q, Zhang C, Guo F, Li Z, Liu Y, Su Z. Novel Bioconjugation Strategy Using Elevated Hydrostatic Pressure: A Case Study for the Site-Specific Attachment of Polyethylene Glycol (PEGylation) of Recombinant Human Ciliary Neurotrophic Factor. Bioconjug Chem. 2017;28:2841-2848 pubmed publisher
    ..human ciliary neurotrophic factor (rhCNTF), and the reagent was monomethoxy-polyethylene glycol-maleimide (mPEG-MAL). PEGylation with mPEG (40 kDa)-MAL at pH 7.0 under normal pressure for 5 h achieved a less than 5% yield...
  61. Crist T, Sorg M. Adult scurvy in New France: Samuel de Champlain's "Mal de la terre" at Saint Croix Island, 1604-1605. Int J Paleopathol. 2014;5:95-105 pubmed publisher
    ..Although limited by a small sample and taphonomic effects, this analysis strongly supports the use of weighted paleopathological criteria to diagnose adult scurvy based on the co-occurrence of specific porotic lesions. ..
  62. Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, et al. TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. PLoS ONE. 2012;7:e38423 pubmed publisher
    ..In MyD88-dependent TLR4 signaling, the function of MyD88 is enhanced by another TIR domain-containing adaptor, Mal/TIRAP, which brings MyD88 to the plasma membrane and promotes its interaction with the cytosolic region of TLR4...
  63. Chowdhury Z, Sato K, Yamamoto D. The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila. Nat Commun. 2017;8:1480 pubmed publisher
    ..Trf2 knockdown in the sexually dimorphic mAL neurons leads to the loss of a male-specific neurite and a reduction in male courtship vigor...
  64. Bitto A, Irrera N, Pizzino G, Pallio G, Mannino F, Vaccaro M, et al. Activation of the EPOR-? common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes. Biochim Biophys Acta Mol Basis Dis. 2018;1864:632-639 pubmed publisher
    ..3, 7, and 14days after the injury to quantitate vascular endothelial growth factor (VEGF), malondialdehyde (MAL), phospho-Akt (pAkt), phospho e-NOS (p-eNOS), and nitrite/nitrate content within the wound...
  65. Ehrle R, Pick C, Ulrich R, Hofmann E, Ehrmann M. Characterization of transmembrane domains 6, 7, and 8 of MalF by mutational analysis. J Bacteriol. 1996;178:2255-62 pubmed
    ..The majority of mutations in membrane-spanning segment 8 caused a Mal+ Dex- phenotype...
  66. Papadopoulos A, Ferwerda B, Antoniadou A, Sakka V, Galani L, Kavatha D, et al. Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection. Cytokine. 2012;60:104-7 pubmed publisher
    MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands...
  67. Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, et al. Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat Immunol. 2008;9:684-91 pubmed publisher
    ..Thus, IRAK2 is critical in late-phase TLR responses, and IRAK1 and IRAK2 are essential for the initial responses to TLR stimulation. ..
  68. Araújo S, Mendonça H, Wheeler N, Campello Costa P, Jacobs K, Gomes F, et al. Inflammatory demyelination alters subcortical visual circuits. J Neuroinflammation. 2017;14:162 pubmed publisher
    ..Using the cuprizone model of inflammatory demyelination, our data reveal a novel form of synaptic (mal)adaption in the CNS that is characterized by a shift of the excitation/inhibition balance toward inhibitory network ..
  69. Deb S, Gorringe K, Pang J, Byrne D, Takano E, Investigators K, et al. BRCA2 carriers with male breast cancer show elevated tumour methylation. BMC Cancer. 2017;17:641 pubmed publisher
    ..methylation by methylation-sensitive high resolution melting in a panel of 10 genes (RASSF1A, TWIST1, APC, WIF1, MAL, RAR?, CDH1, RUNX3, FOXC1 and GSTP1)...
  70. Park J, Choi J, An D, Chang M. Effects of mental practice combined with electromyogram-triggered electrical stimulation for upper extremity function in stroke patients. J Phys Ther Sci. 2017;29:1819-1820 pubmed publisher
    ..Outcome measure included the Fugl-Meyer Assessment (FMA) and Motor Activity Log (MAL). [Results] Experimental group showed more improved in the FMA, MAL-AOU, MAL-QOM compared with the control group...
  71. Peyrottes A, Mariage D, Baque P, Massalou D. Pancreaticoduodenal artery aneurysms due to median arcuate ligament syndrome: what we need to know. Surg Radiol Anat. 2018;40:401-405 pubmed publisher
    Median arcuate ligament (MAL) syndrome is a rare and poorly known cause of abdominal pain. MAL narrows the celiac artery (CA), resulting in true distal aneurysms, including pancreaticoduodenal artery (PDA) aneurysms...
  72. Miao R, Li J, Sun Z, Xu F, Shen H. Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility. Tuberculosis (Edinb). 2011;91:268-72 pubmed publisher
    The missense variant S180L in TIRAP (Toll-interleukin-1 receptor domain-containing adaptor protein) gene is implicated in attenuating TLRs signal transaction and may affect individual response to Mycobacterium tuberculosis infection...
  73. Nguyen T, Kim Y, Kim T, Le O, Kim J, Kang H, et al. Phosphatidylinositol 4-phosphate 5-kinase ? facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location. J Biol Chem. 2013;288:5645-59 pubmed publisher
    ..is also known to mediate plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-dependent Toll-like receptor (TLR) 4 signaling pathway...
  74. Betton J, Hofnung M. Folding of a mutant maltose-binding protein of Escherichia coli which forms inclusion bodies. J Biol Chem. 1996;271:8046-52 pubmed
    ..We have examined the characteristics of a Mal- mutant of malE corresponding to the double substitution Gly32 --> Asp/Ile33 --> Pro, MalE31, previously ..
  75. Comandur R, Olson E, Musier Forsyth K. Conservation of tRNA mimicry in the 5'-untranslated region of distinct HIV-1 subtypes. RNA. 2017;23:1850-1859 pubmed publisher
    ..However, a significant subset of HIV-1 strains represented by the MAL isolate possess a different secondary structure in this region of the genome...
  76. Eto A, Muta T, Yamazaki S, Takeshige K. Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta. Biochem Biophys Res Commun. 2003;301:495-501 pubmed
    ..These results indicate the existence of another signal essential for I kappa B-zeta induction, which is specifically mediated by the TIR domain-mediated signaling pathway. ..
  77. Brint E, Xu D, Liu H, Dunne A, McKenzie A, O Neill L, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol. 2004;5:373-9 pubmed
    ..1 receptor (IL-1RI) and Toll-like receptor 4 (TLR4) but not TLR3 signaling by sequestrating the adaptors MyD88 and Mal. In contrast to wild-type mice, ST2-deficient mice failed to develop endotoxin tolerance...
  78. Yuan H, Shou G, Gleghorn D, Ding L, Cha Y. Resting State Functional Connectivity Signature of Treatment Effects of Repetitive Transcranial Magnetic Stimulation in Mal de Debarquement Syndrome. Brain Connect. 2017;7:617-626 pubmed publisher
    Repetitive transcranial magnetic stimulation (rTMS) has been used in experimental protocols to treat mal de debarquement syndrome (MdDS), a neurological condition that represents a maladaptive brain state resulting from entrainment to ..
  79. Okada Y, Ueda E, Kondo Y, Ishitsuka Y, Irie T, Higashi T, et al. Role of 6-O-?-maltosyl-?-cyclodextrin in lysosomal cholesterol deprivation in Npc1-deficient Chinese hamster ovary cells. Carbohydr Res. 2018;455:54-61 pubmed publisher
    We aimed to investigate whether 6-O-?-maltosyl-?-cyclodextrin (Mal-?CD) is incorporated into cells and lysosomes during the release of unesterified cholesterol in Npc1-deficient Chinese hamster ovary (CHO) cells (Npc1 KO cells) and CHO-..
  80. Kühnau S, Reyes M, Sievertsen A, Shuman H, Boos W. The activities of the Escherichia coli MalK protein in maltose transport, regulation, and inducer exclusion can be separated by mutations. J Bacteriol. 1991;173:2180-6 pubmed
    ..Beside its function in transport, MalK has two additional roles: (i) it negatively regulates mal regulon expression and (ii) it serves as the target for regulation of transport activity by enzyme IIIGlc of the ..
  81. Pan D, Liu G, Xu Y, Wang Y, Yue Y, Wang L, et al. PET Imaging of FSHR Expression in Tumors with 68Ga-Labeled FSH1 Peptide. Contrast Media Mol Imaging. 2017;2017:2674502 pubmed publisher
    ..In vitro studies and MicroPET imaging were performed in PC-3 prostate tumor model. [68Ga] Ga-NOTA-MAL-FSH1 can be produced within 20 min with 93.2 ± 2.1% yield and the radiochemical purity was greater than 95%...
  82. Wu L, Shao X, Guo J, Sun H, Chen Q, Pan J, et al. Vimentin is important in the neural differentiation of PC12 cells promoted by sialylation. Glycoconj J. 2017;34:51-59 pubmed publisher
    ..We noted that CycloManN pro indeed robustly promoted global sialylation detected by MAL II lectin blot in PC12 cells...
  83. Oide S, Inui M. Trehalose acts as a uridine 5'-diphosphoglucose-competitive inhibitor of trehalose 6-phosphate synthase in Corynebacterium glutamicum. FEBS J. 2017;: pubmed publisher
    ..available report on such feedback regulation of TPS is for the silk moth from over 50 years ago [Murphy TA and Wyatt GR (1965) J Biol Chem 240, 1500-1508]...
  84. Dhivya S, Khandelwal N, Abraham S, Premkumar K. Impact of Anthocyanidins on Mitoxantrone-Induced Cytotoxicity and Genotoxicity: An In Vitro and In Vivo Analysis. Integr Cancer Ther. 2016;15:525-534 pubmed
    ..Our study focusses on the modulatory effects of anthocyanidins-malvidin (MAL) and pelargonidin (PEL)-on topoisomerase II poison mitoxantrone (MXT)-induced cytotoxicity and genotoxicity in in ..
  85. Rogawski E, Bartelt L, Platts Mills J, Seidman J, Samie A, Havt A, et al. Determinants and Impact of Giardia Infection in the First 2 Years of Life in the MAL-ED Birth Cohort. J Pediatric Infect Dis Soc. 2017;6:153-160 pubmed publisher
    ..with Giardia in the first 2 years of life in the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED), a multisite birth-cohort study.
  86. Reynaud O, Batailler C, Lording T, Lustig S, Servien E, Neyret P. Three dimensionalCT analysis of femoral tunnel position after ACL reconstruction. A prospective study of one hundred and thirty five cases. Int Orthop. 2017;41:2313-2319 pubmed publisher
    One of the principal causes for failure of anterior cruciate ligament reconstruction (ACL) is femoral tunnel mal-position...
  87. Chen Y, Zhou Q, Li X, Wang F, Heist K, Kuick R, et al. Ultrasmall Paramagnetic Iron Oxide Nanoprobe Targeting Epidermal Growth Factor Receptor for In Vivo Magnetic Resonance Imaging of Hepatocellular Carcinoma. Bioconjug Chem. 2017;28:2794-2803 pubmed publisher
    ..We modified the hydrophobic core with oleic acid and capped with PEGylated phospholipids DSPE-PEG and DSPE-PEG-Mal. The EGFR peptide is attached via thioether-mediated conjugation of a GGGSC linker to the maleimide-terminated ..
  88. Eifinger F, Fuchs Z, Koerber F, Persigehl T, Scaal M. Investigation of umbilical venous vessels anatomy and diameters as a guideline for catheter placement in newborns. Clin Anat. 2017;: pubmed publisher
    ..The aim of the study was to explore the high incidence of mal-positioned UCCs and to improve their positioning. Eighteen stillborns were investigated (29.2 weeks?±?6...
  89. Imamura H, Jeon B, Wakagi T. Molecular evolution of the ATPase subunit of three archaeal sugar ABC transporters. Biochem Biophys Res Commun. 2004;319:230-4 pubmed
    ..DNA sequence comparison revealed that the malK gene was generated through the duplication of the mdxK gene before lateral gene transfer of the mal gene cluster from T. litoralis to Pyrococcus furiosus.
  90. Niazi U, Bibby J, Sutcliffe M. In-silico characterization of the effects of phosphorylated tyrosines 86 and 106 on structure and binding of MAL: insight into hyperinflammatory response to infection by the human malaria parasites. J Recept Signal Transduct Res. 2011;31:53-65 pubmed publisher
    ..signaling pathway, including myeloid differentiation primary response protein (MyD88), MyD88 adapter-like protein (MAL) and suppressor of cytokine signaling 1 (SOCS1), are involved in this inflammatory response...
  91. Capparelli R, De Chiara F, Di Matteo A, Medaglia C, Iannelli D. The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis. Genes Immun. 2013;14:504-11 pubmed publisher
    ..The signaling pathways leading to activation of the immune response require the MyD88 and TIRAP genes...
  92. Sritharan P, Lin Y, Richardson S, Crossley K, Birmingham T, Pandy M. Musculoskeletal loading in the symptomatic and asymptomatic knees of middle-aged osteoarthritis patients. J Orthop Res. 2017;35:321-330 pubmed publisher
    ..and inertia to the tibiofemoral compartment forces in the symptomatic (SYM) and asymptomatic (ASYM) limbs of varus mal-aligned medial knee osteoarthritis (OA) patients, and compared the results with healthy controls (CON)...