Tip60

Summary

Gene Symbol: Tip60
Description: K(lysine) acetyltransferase 5
Alias: ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2, 60 kDa Tat-interactive protein, HIV-1 Tat interactive protein, 60kDa, K-acetyltransferase 5, Tat interacting protein, 60kDa, cPLA(2)-interacting protein, cPLA2 interacting protein, histone acetyltransferase HTATIP
Species: human

Top Publications

  1. ncbi Head-column field-amplified sample stacking in presence of siphoning. Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine
    A B Wey
    Department of Clinical Pharmacology, University of Berne, Switzerland
    J Chromatogr A 924:507-18. 2001
  2. doi Phosphorylation of von Hippel-Lindau protein by checkpoint kinase 2 regulates p53 transactivation
    Jae Seok Roe
    National Research Laboratory for Metabolic Checkpoint, Departments of Biomedical Sciences and Biochemistry and Molecular Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cell Cycle 10:3920-8. 2011
  3. pmc H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
    Clemens Bönisch
    Department of Molecular Biology, Adolf Butenandt Institute, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Nucleic Acids Res 40:5951-64. 2012
  4. pmc Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation
    Kwang Won Jeong
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
    Nat Struct Mol Biol 18:1358-65. 2011
  5. pmc Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription
    Francesco Faiola
    Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
    Mol Cell Biol 25:10220-34. 2005
  6. pmc Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage
    Sudhakar Jha
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Jordan 1240, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Mol Cell Biol 28:2690-700. 2008
  7. pmc Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
    Yingli Sun
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    Nat Cell Biol 11:1376-82. 2009
  8. ncbi Tip60 is a cell-type-specific transcriptional regulator
    F Hlubek
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    J Biochem 129:635-41. 2001
  9. pmc Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1)
    Chao Dai
    Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA
    J Biol Chem 288:19581-92. 2013
  10. pmc The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60
    Jagruti H Patel
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell Biol 24:10826-34. 2004

Detail Information

Publications273 found, 100 shown here

  1. ncbi Head-column field-amplified sample stacking in presence of siphoning. Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine
    A B Wey
    Department of Clinical Pharmacology, University of Berne, Switzerland
    J Chromatogr A 924:507-18. 2001
    ..CE) with head-column field-amplified sample stacking (FASS) in presence of a water plug inserted at the capillary tip is a robust approach providing a more than 1000-fold sensitivity enhancement when applied to low-conductivity ..
  2. doi Phosphorylation of von Hippel-Lindau protein by checkpoint kinase 2 regulates p53 transactivation
    Jae Seok Roe
    National Research Laboratory for Metabolic Checkpoint, Departments of Biomedical Sciences and Biochemistry and Molecular Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cell Cycle 10:3920-8. 2011
    ..Notably, this modification enhances pVHL-mediated transactivation of p53 by recruiting p300 and Tip60 to the chromatin of p53 target gene...
  3. pmc H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
    Clemens Bönisch
    Department of Molecular Biology, Adolf Butenandt Institute, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Nucleic Acids Res 40:5951-64. 2012
    ..Furthermore, we demonstrate the binding of Z.2.2 to H2A.Z-specific TIP60 and SRCAP chaperone complexes and its active replication-independent deposition into chromatin...
  4. pmc Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation
    Kwang Won Jeong
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
    Nat Struct Mol Biol 18:1358-65. 2011
    ..We demonstrate that multiple protein-protein interactions by the protein acetyltransferase TIP60 are required for estrogen-induced transcription of a subset of estrogen receptor alpha (ERα) target genes in ..
  5. pmc Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription
    Francesco Faiola
    Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
    Mol Cell Biol 25:10220-34. 2005
    ..activation domain (TAD) that recruits cofactor complexes containing the histone acetyltransferases (HATs) GCN5 and Tip60. Here, we report a novel functional interaction between Myc TAD and the p300 coactivator-acetyltransferase...
  6. pmc Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage
    Sudhakar Jha
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Jordan 1240, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Mol Cell Biol 28:2690-700. 2008
    ..are part of various chromatin-remodeling complexes, such as Ino80, SNF2-related CBP activator protein (SRCAP), and Tip60/NuA4 complexes, but their molecular function is unclear...
  7. pmc Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
    Yingli Sun
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    Nat Cell Biol 11:1376-82. 2009
    DNA double-strand break (DSB) repair involves complex interactions between chromatin and repair proteins, including Tip60, a tumour suppressor...
  8. ncbi Tip60 is a cell-type-specific transcriptional regulator
    F Hlubek
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    J Biochem 129:635-41. 2001
    b>Tip60 was originally identified as cellular HIV-Tat interacting protein and has been shown to augment Tat-dependent transcription...
  9. pmc Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1)
    Chao Dai
    Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA
    J Biol Chem 288:19581-92. 2013
    ..We and others previously showed that TIP60 (Tat-interacting protein of 60 kDa)-mediated acetylation of p53 at K120 is crucial for p53-dependent apoptotic ..
  10. pmc The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60
    Jagruti H Patel
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell Biol 24:10826-34. 2004
    ..on the recruitment of cofactor complexes containing the histone acetyltransferases mammalian GCN5 (mGCN5)/PCAF and TIP60. In addition to acetylating histones, these enzymes have been shown to acetylate other proteins involved in ..
  11. pmc p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress
    Beatrice Eymin
    Groupe de Recherche sur le Cancer du Poumon, INSERM U578, Institut Albert Bonniot, 38706 La Tronche Cedex, France
    Mol Cell Biol 26:4339-50. 2006
    ..signaling pathways contributes to this G2 checkpoint and highlight the interrelated roles of p14ARF and the Tip60 protein in the initiation of this DNA damage-signaling cascade...
  12. doi Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus
    Masaki Shiota
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Prostate 70:540-54. 2010
    ..CRPC which is resistant to castration is thought to result from increased activation of the androgen/androgen receptor (AR) signaling pathway, which may be augmented by AR coactivators...
  13. pmc A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
    Yingli Sun
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:13182-7. 2005
    ..Here, we demonstrate that DNA damage induces the rapid acetylation of ATM. This acetylation depends on the Tip60 histone acetyltransferase (HAT)...
  14. ncbi von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity
    Maria V Panchenko
    Department of Medicine, Sections of Nephrology and Hematology Oncology, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    J Biol Chem 279:56032-41. 2004
    ..In addition, we demonstrated that TIP60, a known HAT with histone H4/H2A specificity, physically associates with Jade-1 and is able to augment Jade-1 HAT ..
  15. pmc Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans
    Yannick Doyon
    Laval University Cancer Research Center, Hotel Dieu de Quebec, Quebec City, Quebec G1R 2J6, Canada
    Mol Cell Biol 24:1884-96. 2004
    ..We demonstrate here that NuA4 complexes are indeed present in human cells. Tip60 and its splice variant Tip60b/PLIP were purified as stable HAT complexes associated with identical polypeptides, ..
  16. doi HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex
    Shi Meng Zhang
    Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing, China
    Cell Cycle 11:1217-34. 2012
    ..Knocking down Tip60, an interactive protein of Tat, leads to the impairment of cell cycle progression, indicating a key role of Tip60 ..
  17. pmc DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
    Tsuyoshi Ikura
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryoumachi 2 1, Aobaku Sendai 980 8575, Japan
    Mol Cell Biol 27:7028-40. 2007
    ..Among proteins involved in chromatin reorganization, TIP60 histone acetyltransferase has been shown to play a role in DNA repair and apoptosis...
  18. ncbi Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
    Yi Tang
    Institute for Cancer Genetics, Surgeons, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mol Cell 24:827-39. 2006
    ..Here, we show that Tip60 is required for both cell growth arrest and apoptosis mediated by p53 and also induces its acetylation ..
  19. ncbi The highly conserved and multifunctional NuA4 HAT complex
    Yannick Doyon
    Laval University Cancer Research Center, Hôtel Dieu de Québec CHUQ, 9 McMahon Street, Quebec City, Qc G1R 2J6 Canada
    Curr Opin Genet Dev 14:147-54. 2004
    ..Recent studies presented here have established its remarkable structural conservation from yeast to human cells and contributed to the understanding of its diverse functions...
  20. ncbi Cellular functions of TIP60
    Vasileia Sapountzi
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Int J Biochem Cell Biol 38:1496-509. 2006
    b>TIP60 was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. As a consequence, the role of TIP60 in transcriptional regulation has been investigated intensively...
  21. ncbi Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
    Rabih Murr
    International Agency for Research on Cancer IARC, 150 cours Albert Thomas, 69008 Lyon, France
    Nat Cell Biol 8:91-9. 2006
    ..Here, we show that the HAT cofactor Trrap and Tip60 HAT bind to the chromatin surrounding sites of DNA double-strand breaks (DSBs) in vivo...
  22. pmc The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression
    Jeong Hyeon Park
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Mol Cell Biol 30:2750-61. 2010
    The TIP60 histone acetyltransferase plays diverse roles in DNA damage responses, DNA double-strand break repair, and transcriptional regulation...
  23. pmc Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60-dependent transcriptional regulation and apoptotic pathway
    Sudhakar Jha
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 38:700-11. 2010
    The TIP60 tumor suppressor is a histone acetyltransferase involved in transcriptional regulation, checkpoint activation, and p53-directed proapoptotic pathways...
  24. ncbi Tip60 acetylates six lysines of a specific class in core histones in vitro
    A Kimura
    Department of Cellular Biology, University of Tokyo, Japan
    Genes Cells 3:789-800. 1998
    b>Tip60, an HIV-1-Tat interactive protein, is a nuclear histone acetyltransferase (HAT) with unique histone substrate specificity...
  25. ncbi Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response
    Z Cheng
    Cellular Dynamics, Hefei National Laboratory, Hefei, China
    Oncogene 27:931-41. 2008
    The histone acetyltransferase TIP60 regulates the DNA damage response following genotoxic stress by acetylating histone and remodeling chromatin...
  26. ncbi Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60
    T Yamamoto
    Laboratory of Developmental Biology, Department of Cellular Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 272:30595-8. 1997
    b>Tip60, originally isolated as an HIV-1-Tat interactive protein, contains an evolutionarily conserved domain with yeast silencing factors...
  27. ncbi Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
    T Ikura
    Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 102:463-73. 2000
    ..Here, we present evidence for novel roles of histone acetylases. The TIP60 histone acetylase purifies as a multimeric protein complex...
  28. doi The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways
    L Mattera
    LBCMCP, CNRS, Toulouse, Franc
    Oncogene 28:1506-17. 2009
    The Tip60 histone acetyltransferase belongs to a multimolecular complex that contains many chromatin remodeling enzymes including the ATPase p400, a protein involved in nucleosomal incorporation of specific histone variants and that can ..
  29. pmc Regulation of TIP60 by ATF2 modulates ATM activation
    Anindita Bhoumik
    Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:17605-14. 2008
    TIP60 (HTATIP) is a histone acetyltransferase (HAT) whose function is critical in regulating ataxia-telangiectasia mutated (ATM) activation, gene expression, and chromatin acetylation in DNA repair...
  30. ncbi Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1
    Qiming Li
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 279:10542-50. 2004
    ..may function as a transcriptional activator in a complex with the adaptor protein Fe65 and the nuclear protein Tip60. APP is closely related to APP-like protein (APLP) 1 and APLP2, but only APP is known to be cleaved by BACE 1 and ..
  31. ncbi The p400 complex is an essential E1A transformation target
    M Fuchs
    Dana Farber Cancer Institute, Boston, MA, USA
    Cell 106:297-307. 2001
    ..Furthermore, E1A and c-myc each alter the subunit composition of p400 complexes, implying that physiological p400 complex formation contributes to transformation suppression...
  32. ncbi Role of the histone acetyl transferase Tip60 in the p53 pathway
    Gaelle Legube
    Laboratoire de Biologie Moleculaire Eucaryote, UMR 5099, CNRS and Université Paul Sabatier, IEFG IFR 109, 118 route de Narbonne, Universite Paul Sabatier, 31062 Toulouse, France
    J Biol Chem 279:44825-33. 2004
    The histone acetyl transferase Tip60 (HTATIP) shares many properties with the tumor suppressor p53 (TP53)...
  33. ncbi Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex
    Yong Cai
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Biol Chem 278:42733-6. 2003
    ..previously found to be a component of a multi-protein histone acetyltransferase (HAT) complex containing the HAT TIP60. In this report, we identify a previously uncharacterized protein encoded by the FLJ10914 ORF, which we designate ..
  34. pmc Chromatin dynamics associated with HIV-1 Tat-activated transcription
    Rebecca Easley
    The George Washington University Medical Center, Department of Microbiology, Immunology, and Tropical Medicine, Washington, DC 20037, USA
    Biochim Biophys Acta 1799:275-85. 2010
    ..Finally, we cover recent literature on viral microRNAs which have been shown to alter chromatin structure by inducing methylation or even by remodeling nucleosomes...
  35. ncbi Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat
    M Creaven
    Equipe de Chromatine et Expression des Génes, Equipe d Assemblage et Régulation de l Appareil Génétique, Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation, INSERM U309, France
    Biochemistry 38:8826-30. 1999
    b>Tip60, a cellular histone-acetyltransferase, is known to interact with the HIV-1-encoded transactivator protein, Tat...
  36. pmc The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor
    Iver Nordentoft
    Department of Molecular Biology, Aarhus University, C F Møllers Allé 130, DK 8000 Aarhus C, Denmark
    Biochem J 374:165-73. 2003
    ..Among the interacting partners, we identified the histone acetyltransferase protein Tip60 [60 kDa trans-acting regulatory protein of HIV type 1 (Tat)-interacting protein]...
  37. ncbi Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator
    J Kamine
    Institute for Molecular Virology, St Louis University School of Medicine, Missouri 63110, USA
    Virology 216:357-66. 1996
    ..identified the full-length cDNA for the Tat binding protein and shown that overexpression of the encoded protein, Tip60 (Tat interactive protein, 60 kDa), results in a fourfold augmentation of Tat transactivation of the HIV-1 promoter ..
  38. pmc HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?
    Giuseppe Nunnari
    University of Catania, Department of Medicine and Medical Specialties, Division of Infectious Diseases, Via Palermo 636, Catania, Italy
    J Exp Clin Cancer Res 27:3. 2008
    ..We propose that the Tat-induced DNA repair deficiencies may play a significant role in the development of AIDS-associated cancer...
  39. ncbi The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes
    Yong Cai
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Biol Chem 280:13665-70. 2005
    The multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase (HAT) complex performs critical functions in a variety of cellular processes including transcriptional activation, double strand DNA break repair, and apoptosis...
  40. ncbi Tip60 is a co-activator specific for class I nuclear hormone receptors
    L Gaughan
    Prostate Research Group, School of Surgical Sciences, University of Newcastle upon Tyne Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 276:46841-8. 2001
    ..b>Tip60 (Tat-interactive protein 60 kDa), previously shown to bind to and enhance androgen receptor (AR)-mediated ..
  41. ncbi Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor
    Luke Gaughan
    Prostate Research Group, School of Surgical Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 277:25904-13. 2002
    ..We have previously shown that Tip60 (Tat-interactive protein, 60 kDa) is a bona fide co-activator protein for the AR...
  42. ncbi Identification of an alternatively spliced form of the Tat interactive protein (Tip60), Tip60(beta)
    Q Ran
    Baylor College of Medicine, The Huffington Center on Aging, 1 Baylor Plaza, M320, N803, Houston, TX 77030, USA
    Gene 258:141-6. 2000
    b>Tip60 was originally isolated as a Tat interactive protein. It was subsequently shown that Tip60 had histone acetyltransferase (HAT) activity...
  43. ncbi Tip60 is a nuclear hormone receptor coactivator
    M E Brady
    Prostate Research Group, Department of Surgery, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 274:17599-604. 1999
    ..Using a COOH-terminal region of the human AR in a yeast two-hybrid screen, we have identified Tip60 as an AR-interacting protein...
  44. pmc PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production
    A M Sheridan
    Medical Services, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 21:4470-81. 2001
    ..We have identified a nuclear protein, cPLA(2)-interacting protein (PLIP), a splice variant of human Tip60, which interacts with the amino terminal region of cPLA(2)...
  45. ncbi Tip60 is a co-repressor for STAT3
    Hui Xiao
    Department of Pharmacology and Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 278:11197-204. 2003
    b>Tip60 (Tat-interactive protein, 60 kDa), a cellular protein with intrinsic histone acetyltransferase activity, is involved in DNA damage repair and apoptosis...
  46. ncbi A large-scale RNAi screen in human cells identifies new components of the p53 pathway
    Katrien Berns
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 428:431-7. 2004
    ..Furthermore, we describe siRNA bar-code screens to rapidly identify individual siRNA vectors associated with a specific phenotype. These new tools will greatly facilitate large-scale loss-of-function genetic screens in mammalian cells...
  47. ncbi Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway
    Ping Zhu
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 124:615-29. 2006
    ....
  48. ncbi The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM
    Xiaofeng Jiang
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:15741-6. 2006
    ..The FATC domain of ATM mediates the interaction between ATM and Tip60, a histone acetyltransferase that regulates activation of ATM...
  49. pmc Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression
    Sandrine Tyteca
    Laboratoire de Biologie Moléculaire Eucaryote LBME, UMR 5099 CNRS Université Paul Sabatier, Institut d Exploration Fonctionnelle des Génomes IEFG, Toulouse, France
    EMBO J 25:1680-9. 2006
    The histone acetyl transferase Tip60 (HTATIP) belongs to a multimolecular complex involved in the cellular response to DNA damage...
  50. pmc Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation
    Gaelle Legube
    Laboratoire de Biologie Moleculaire Eucaryote, CNRS UMR 5099, 118 route de Narbonne, Universite Paul Sabatier, 31062 Toulouse, France
    EMBO J 21:1704-12. 2002
    ..Here, we show that the HAT Tip60, which is involved in DNA repair and apoptosis following gamma irradiation, is subjected to proteasome-dependent ..
  51. pmc HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses
    Edwige Col
    Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation, INSERM U309, Equipe chromatine et expression des gènes, Institut Albert Bonniot, Faculte de Medecine, Domaine de la Merci, La Tronche, France
    EMBO J 24:2634-45. 2005
    ..Although Tip60 was the first HAT identified to interact with Tat, the biological significance of this interaction has remained ..
  52. ncbi The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma
    Olivier Van Beekum
    Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands
    Endocrinology 149:1840-9. 2008
    ..Here we identify the HIV-1 Tat-interacting protein 60 (Tip60) as a novel positive regulator of PPARgamma transcriptional activity...
  53. ncbi Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
    Chiara Gorrini
    Department of Experimental Oncology, European Institute of Oncology IEO, IFOM IEO Campus, Milan 20139, Italy
    Nature 448:1063-7. 2007
    ..Using E(mu)-myc transgenic mice that are heterozygous for a Tip60 gene (Htatip) knockout allele (hereafter denoted as Tip60+/- mice), we show that Tip60 counteracts Myc-induced lymphomagenesis ..
  54. ncbi In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail
    Evdokia Pasheva
    Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Biochemistry 43:2935-40. 2004
    Histone acetyltransferases CBP, PCAF, and Tip60 have been tested for their ability to in vitro acetylate HMGB-1 and -2 proteins and their truncated forms lacking the C-terminal tail...
  55. ncbi Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein
    Sung Hee Baek
    Howard Hughes Medical Institute, Department of Molecular Medicine, La Jolla, CA 92093, USA
    Cell 110:55-67. 2002
    ..Nuclear export of the N-CoR/TAB2/HDAC3 complex by IL-1beta is temporally linked to selective recruitment of a Tip60 coactivator complex...
  56. ncbi Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes
    Jung Hwa Kim
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 742, South Korea
    Nature 434:921-6. 2005
    ..The coordinated actions of beta-catenin-reptin components that mediate the repressive state serve to antagonize a Tip60 coactivator complex that is required for activation; the balance of these opposing complexes controls the ..
  57. pmc MYC recruits the TIP60 histone acetyltransferase complex to chromatin
    Scott R Frank
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    EMBO Rep 4:575-80. 2003
    ..MYC associates with TRRAP, a subunit of distinct macromolecular complexes that contain the HATs GCN5/PCAF or TIP60. Although the association of MYC with GCN5 has been shown, its interaction with TIP60 has never been analysed...
  58. ncbi Identification of a larger form of the histone acetyl transferase Tip60
    Gaelle Legube
    Laboratoire de Biologie Moleculaire Eucaryote, UMR 5099 CNRS, Institut d Exploration Fonctionnelle des Génomes, IFR 109 CNRS, 118, route de Narbonne, 31 062, Toulouse Cedex, France
    Gene 310:161-8. 2003
    The histone acetyl transferase Tat interactive protein 60kD (Tip60) plays major roles in the cellular response to extra- or intra-cellular signalling...
  59. ncbi Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins
    Flavia C Nery
    Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, Rua Giuseppe Máximo Scolfaro 10 000, C P 6192, 13084 971 Campinas, SP, Brazil
    Biochem Biophys Res Commun 341:847-55. 2006
    ..Furthermore, we found that the phosphorylation of p53 by PKC abolishes its interaction with Ki-1/57 in vitro...
  60. pmc Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation
    Mi Yeon Kim
    Hormonre Research Center, School of Biological Sciences and Technology, Chonnam National University, Yongbong Dong, Buk Ku, Gwangju 500 757, South Korea
    Mol Cell Biol 27:6506-19. 2007
    ..In our present study, we provide evidence that UV irradiation-induced Tip60 proteins reduced Notch1 activity to a marked degree...
  61. ncbi Tip60 inhibits activation of CREB protein by protein kinase A
    S Gavaravarapu
    Infectious Diseases Section, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biochem Biophys Res Commun 269:758-66. 2000
    We have previously identified a cDNA encoding a cellular protein, Tip60 (Tat interactive protein, 60 kDa), that specifically interacts with the Tat (transactivating transcriptional regulator) protein of the human immunodeficiency virus-1 ..
  62. pmc Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999
    ..C (PC-PLC), phospholipase D (PLD), and the high molecular weight (85 kDa) cytosolic phospholipase A2 (cPLA2) to induce phosphatidylcholine (PC) metabolism, production of diacylglycerol (DAG) and arachidonic acid (AA), ..
  63. pmc Histone acetylation at promoters is differentially affected by specific activators and repressors
    J Deckert
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:2726-35. 2001
    ..We speculate that the activator-specific decrease in histone H4 acetylation is due to blocking the access or function of an H4-specific histone acetylase such as Esa1.
  64. ncbi Prevention of compartment syndrome in dorsal root ganglia caused by exposure to nucleus pulposus
    S Yabuki
    Department of Anesthesiology and Pathology Neuropathology, VA Medical Center and the University of California at San Diego, La Jolla, California, USA
    Spine (Phila Pa 1976) 26:870-5. 2001
    ..Endoneurial fluid pressure was recorded with a servo-null micropipette system using glass micropipettes with tip diameters of 4 microm...
  65. ncbi Acute effects of nucleus pulposus on blood flow and endoneurial fluid pressure in rat dorsal root ganglia
    S Yabuki
    Department Orthopaedic Surgery, Fukushima Medical College, Japan
    Spine (Phila Pa 1976) 23:2517-23. 1998
    ..Endoneurial fluid pressures were recorded with a servonull micropipette system using glass micropipettes with tip diameters of 4 microns...
  66. ncbi [Bacteremia with Acinetobacter species--clinicopathological characteristics of 27 cases]
    I Kurosu
    First Department of Internal Medicine, Nihon University School of Medicine
    Kansenshogaku Zasshi 69:895-902. 1995
    ..Nine cases became afebrile after the removal of the catheter and A. anitratus was isolated from the catheter tip in four cases. Heparin was administered through the catheter in 7 cases. Formerly Acinetobacter spp...
  67. ncbi [A clinical investigation of bacteremia for the past ten years at the Second Department of Internal Medicine, Jikei University Hospital]
    H Maezawa
    Second Department of Internal Medicine, Jikei University School of Medicine
    Kansenshogaku Zasshi 72:820-6. 1998
    ..All of the subjects who had a positive reaction to blood culture or catheter tip culture were investigated for their basic disease, complications, and detected bacteria...
  68. ncbi [Comparative computerized tomography cephalometric and pharyngometric studies of patients with severe and mild sleep apnea, and in a control group]
    J Bolitschek
    Pneumologische Abteilung, K.H. Elisabethinen, Linz
    Pneumologie 47:757-60. 1993
    ..the pharynx was measured; other measured sites were the areas of the nasopharynx, oropharynx (at the level of the tip of the palatine uvula) and of the hypopharynx (at the level of the base of the tongue)...
  69. ncbi Spontaneous arousals during quiet sleep in piglets: a visual and wavelet-based analysis
    B BuSha
    Department of Physiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    Sleep 24:499-513. 2001
    ..instrumented with a femoral arterial line, EEG, EOG, EMG electrodes, and a micro-dialysis probe with its tip located in the rostral ventral medulla...
  70. ncbi TIP 1, a cold shock-inducible gene of Saccharomyces cerevisiae
    K Kondo
    Department of Biochemistry, Robert Wood Johnson Medical School, Rutgers, University of Medicine and Dentistry of New Jersey, Piscataway 08854 5635
    J Biol Chem 266:17537-44. 1991
    ..Surprisingly, its expression was also induced by heat shock, and thus the gene was designated TIP 1 (temperature shock-inducible protein gene)...
  71. ncbi Dissolution rate of hen egg-white lysozyme crystal under microgravity
    N Niimura
    Advanced Science Research Center, Japan Atomic Energy Research Institute, Ibaraki Ken, Japan
    Biol Sci Space 15:S176. 2001
    ..Dissolution of the crystal was started by extruding the unsaturated solutions onto the syringe tip with the crystal. The crystal dissoluted in 40 ml droplets that are extruded from syringes...
  72. ncbi Molecular genetics of root gravitropism and waving in Arabidopsis thaliana
    J Sedbrook
    Laboratory of Genetics, University of Wisconsin-Madison, USA
    Gravit Space Biol Bull 11:71-8. 1998
    ..This reflects their ability to sense the gravity vector and to position their tip parallel to it (gravitropism)...
  73. ncbi Determination of tobacco alkaloids in single plant cells by capillary electrophoresis
    H Lochmann
    Department of Chemistry, Institute of Inorganic Chemistry, Darmstadt University of Technology, Germany
    J Chromatogr A 917:311-7. 2001
    ..The results indicate a gradient of nicotine from the leaf base to the tip with higher concentrations present in the cells at the tip...
  74. pmc Pulmonary atresia with ventricular septal defect: a case for central venous pressure and oxygen saturation monitoring
    B M Weiss
    Department of Anesthesiology, University Hospital, Zurich, Switzerland
    Yale J Biol Med 71:15-21. 1998
    ..Invasive arterial and central venous (CVP) pressure, pulse oximetric oxygen saturation (SpO2), and (from the tip of oximetric central venous catheter) central venous oxygen saturation (ScvO2) and oxygen extraction rate (ExO2) ..
  75. ncbi The effects of soft segment structure on the fatigue crack propagation of model polyurethanes
    H J Kim
    Department of Material Science and Engineering, University of Tennessee, Knoxville 37966-2200
    Biomed Mater Eng 4:171-85. 1994
    ..In addition the orientation behavior at the crack tip was characterized by IR dichroism technique using a polarized FT-IR microscope...
  76. ncbi Comparison of cephalometric analysis with ethnicity in obstructive sleep apnea syndrome
    M J Will
    Department of Oral and Maxillofacial Surgery, Brooke Army Medical Center, Fort San Houston, Texas 78234, USA
    Sleep 18:873-5. 1995
    ..SNB (ANB), perpendicular distance from gonion to gnathion to hyoid (MP-H), distance from posterior nasal spine to tip of soft palate (PNS-P) and posterior airway space (PAS)] commonly used in the evaluation of OSAS patients were ..
  77. ncbi [Subtype and sequence analysis of the C2-V3 region of gp120 genes among human immunodeficiency virus infected IDUs in Ruili epidemic area of Yunnan Province of China]
    Y Guan
    Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:8-12. 1997
    ..The analysis of V3 loop amino sequence of 12 subtype B HIV-1 reveals that V3-tip motif of 6 samples (50%) is GPGQ and that of 3 samples (25%) is GPGR...
  78. ncbi Wrist arthroplasty with a new generation of prostheses in patients with rheumatoid arthritis
    S Radmer
    Department of Rheumatic Surgery, Immanuel Hospital, Berlin, Germany
    J Hand Surg Am 24:935-43. 1999
    ..articular surface inclination of 10 degrees toward the ulna, and the carpal component, which is anchored with its tip in the distal carpal bones and third metacarpal bone, has a double articular surface with a radial inclination of ..
  79. ncbi Intense peripheral electrical stimulation differentially inhibits tail vs. limb withdrawal reflexes in the rat
    V V Romita
    Department of Psychiatry, McGill University, Montreal, Que, Canada
    Brain Res 720:45-53. 1996
    ..Withdrawal was evoked by application of noxious radiant heat to the tip of the tail or to the plantar surface of a hindpaw or forepaw...
  80. ncbi Measurement of phenols on a loop-supported liquid film by micellar electrokinetic chromatography and direct UV detection
    S Kar
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock 79409-1061, USA
    J Chromatogr A 739:379-87. 1996
    ..D.) is formed with 100 mm Pt-wire at the sampling end of a fused-silica capillary. The capillary tip of the sampling end is present at the center of the loop and in the same plane. A thin film of 0...
  81. ncbi Using capillary electrophoresis to study the chemical conditions within cracks in aluminum alloys
    K R Cooper
    Department of Materials Science and Engineering, University of Virginia, Charlottesville 22903, USA
    J Chromatogr A 850:381-9. 1999
    ..of the crack solutions in EAC-susceptible material revealed high levels of Al3+, Mg2+, Zn2+, and Cl- near the crack tip. Cations arise from the anodic dissolution of the alloy, whereas chloride ingress from the external environment ..
  82. ncbi Atlantoaxial instability in Lesch-Nyhan syndrome
    P C Shewell
    Royal Orthopaedic Hospital, Birmingham, United Kingdom
    Spine (Phila Pa 1976) 21:757-62. 1996
    ..Radiology including computed tomography scanning showed fracture of the tip of the odontoid and forward subluxation of the atlas. He was treated with a C1-C2 Gallie fusion...
  83. ncbi [A new method of laser angioplasty by contact sapphire: preliminary results. Apropos of 20 cases]
    J L Fourrier
    Service de cardiologie B, , France
    Arch Mal Coeur Vaiss 81:253-8. 1988
    We report our first 20 cases of peripheral laser angioplasty using an optic fibre with contact sapphire tip. The equipment included a teflon catheter on which was screwed a round sapphire 2.2 mm in diameter...
  84. ncbi Contraction and relaxation of upper airway muscles during expiratory application of negative pressure at the mouth
    A Sanna
    Pulmonary Laboratory and Division, Cliniques Universitaires Saint-Luc, Brussels, Belgium
    Sleep 17:220-5. 1994
    ..Supraglottic pressure (Psg) was measured with a catheter with the tip at the supraglottic level...
  85. ncbi Postoperative pain control after lumbar spine fusion. Patient-controlled analgesia versus continuous epidural analgesia
    B E Cohen
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina, USA
    Spine (Phila Pa 1976) 22:1892-6; discussion 1896-7. 1997
    ..However, possible technical limitations (namely, the low dosage of bupivacaine and placement of the catheter tip) may have prevented adequate delivery of anesthetic to the involved segments...
  86. pmc Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli
    M Batchelor
    Department of Biochemistry and Centre for Structural Biology, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    EMBO J 19:2452-64. 2000
    ..rod of immunoglobulin domains extending from the bacterium surface, conveying a highly accessible 'adhesive tip' to the target cell...
  87. ncbi Rapp-Hodgkin syndrome with pili canaliculi
    F Camacho
    Department of Medico-Surgical Dermatology, Sevilla, Spain
    Pediatr Dermatol 10:54-7. 1993
    ..ectodermal dysplasia, cleft lip and palate, midfacial hypoplasia with narrow nose from the nasal bridge to the tip, narrow dysplastic nails, and conical teeth and hypodontia, and hypospadias and hypoplastic uvula in the boy...
  88. ncbi [Results of pulsed laser angioplasty of peripheral arteries guided by spectroscopy]
    H Geschwind
    Service d'explorations fonctionnelles et INSERM U2, CHU Henri-Mondor,
    Arch Mal Coeur Vaiss 84:1837-43. 1991
    ..The therapeutic laser was only activated when atheromatous tissue was in contact with the distal tip of the fiber optic. After vaporizing a narrow pilot channel conventional balloon angioplasty was performed...
  89. pmc Brachial plexus anesthesia: an analysis of options
    D L Brown
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55901
    Yale J Biol Med 66:415-31. 1993
    ..The final needle tip position with this block is potentially near the centroneuraxis and arteries perfusing the brain, thus careful ..
  90. ncbi Biomechanics of the thumb flexor pulley system
    A G Zissimos
    Department of Orthopaedics, University of California, Davis, Sacramento 95817
    J Hand Surg Am 19:475-9. 1994
    ..Each forearm was mounted to a dynamic testing apparatus, and an 815 g load was applied at the thumb tip. The flexor pollicus longus tendon was attached to a force transducer and computer-driven stepper motor, and ..
  91. ncbi Neural correlates of habituation of the proleg withdrawal reflex in larvae of the hawk moth, Manduca sexta
    E R Wood
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    J Comp Physiol A 180:639-57. 1997
    ..This reflex is evoked by deflecting one or more mechanosensory planta hairs on a proleg tip. We examined neural correlates of habituation in an isolated proleg preparation consisting of one proleg and its ..
  92. ncbi Battering during pregnancy: tip of an iceberg revealed
    J McFarlane
    College of Nursing, Texas Woman s University, Houston 77030
    Women Health 15:69-84. 1989
    ....
  93. ncbi [Primary results of laser recanalization in the endovascular treatment of arterial stenosis and occlusion of the lower limbs. Apropos of 45 treated cases]
    V Poyen
    Service de cardiologie, , Marseille
    Arch Mal Coeur Vaiss 84:1537-41. 1991
    ..The use of thermal laser with hybrid catheters (metallic window tip) in endovascular procedures is a safe and effective method of treating stenosis and occlusion of lower limb arteries...
  94. ncbi [Effect of preventive measures against central venous catheter-related infection: retrospective study in our division for recent 10 years]
    Y Hanatani
    First Department of Surgery, Teikyo University School of Medicine
    Kansenshogaku Zasshi 73:1032-7. 1999
    ..as CVC-related infection when the fever dropped immediately (within 72 hours) after removal of CVC, or when the tip of the CVC was positive for culture. The rate of CVC-related infection in the second (9.9%) or the third (7...
  95. ncbi Gaps in cardiovascular medication taking: the tip of the iceberg
    P Rudd
    Department of Medicine, Stanford University Medical Center, CA 94305-5475
    J Gen Intern Med 8:659-66. 1993
    ..The compliance patterns and gaps may contribute to reported excesses of cardiovascular morbidity and mortality...
  96. ncbi Concentration and separation of hypoglycemic drugs using solid-phase extraction-capillary electrophoresis
    M A Strausbauch
    Department of Surgery, Mayo Clinic/Mayo Foundation, Rochester, MN 55905, USA
    J Chromatogr A 717:279-91. 1995
    ..Not only was resolution of the desorbed material uncompromised by the presence of the SPE-tip, but separation of glipizide and glyburide was observed despite the fact that these drugs were unresolved under the ..
  97. ncbi A new technique for endoscopic carpal tunnel decompression
    T M Tsai
    Christine M Kleinert Institute for Hand and Micro Surgery, Louisville, Kentucky, USA
    J Hand Surg Br 20:465-9. 1995
    ..No injuries to tendons, nerves, or arteries were noted. In one case the cotton tip was lost from the stick...
  98. ncbi Safety and accuracy of transarticular screw fixation C1-C2 using an aiming device. An anatomic study
    J S Gebhard
    Lakewood Orthopaedic Clinic, Colorado, USA
    Spine (Phila Pa 1976) 23:2185-9. 1998
    ..Screw length averaged 45 mm and, with proper length, the screw tip was found to be located approximately 7.5 mm behind the anterior tubercle of C1 on lateral radiographs...
  99. ncbi The effectiveness of triclosan-incorporated plastic against bacteria on beef surfaces
    C N Cutter
    U S Department of Agriculture, Agricultural Research Service, Roman L Hruska U S Meat Animal Research Center, Clay Center, Nebraska 68933, USA
    J Food Prot 62:474-9. 1999
    ..Plate overlay assays indicated that the triclosan-incorporated plastic (TIP) inhibited the following organisms: Brochothrix thermosphacta ATCC 11509, Salmonella Typhimurium ATCC 14028, ..
  100. ncbi The improved Allium/Vicia root tip micronucleus assay for clastogenicity of environmental pollutants
    T H Ma
    Department of Biological Sciences, Western Illinois University, Macomb 61455, USA
    Mutat Res 334:185-95. 1995
    ..of the efficiency of these two plant systems and in different cell populations (meristem and F1) of the root tip as well as under adequate recovery duration...
  101. ncbi [Evaluation by Doppler echocardiography of systolic and diastolic functions of the left ventricle of the athlete's heart]
    A Cohen
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 82:55-62. 1989
    ..The following doppler parameters were measured at the annulus (a) and tip (p) of the mitral valve leaflets: protodiastolic velocity peak (E), velocity peak during atrial systole (A) and A/E ..

Research Grants70

  1. Improved Targeting and Assessment of Electrophysiology Intervention
    Henry R Halperin; Fiscal Year: 2013
    ..We hypothesize that high resolution imaging with MRI, and/or CT, with compatible electrode catheters, catheter-tip location sensors, remote-controlled catheter manipulators, real-time scanner control, thermal imaging, and 4-..
  2. Low-Dose Tomosynthetic Interventional System For Quantitative Cardiac Imaging
    Michael A Speidel; Fiscal Year: 2013
    ..that exploit the unique SBDX real-time, multiplane, tomosynthetic reconstructor: frame-by-frame 3D catheter tip tracking and calibration-free 3D vessel analysis for device sizing...
  3. Optimal Prevention and Control of Periodontal Disease: The Periodontal Pocket Irr
    Thomas E Van Dyke; Fiscal Year: 2011
    ..The curved, illuminating, rotatively adjustable, cannula tip simply penetrates the periodontal pockets in the dark areas of the molars...
  4. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..and time dependent development of an aseptic granuloma (neutrophils and macrophages) proximal to the catheter tip, arising from the dura-arachnoid layer...
  5. Endovascular Magnetic Catheter for Interventional MRI
    STEVEN WILLIAM HETTS; Fiscal Year: 2013
    ..MRI, the strong homogeneous magnetic (B0) field inside the MRI scanner provides a unique opportunity for catheter tip navigation by remote control...
  6. Acoustically Active Catheter for Echocardiographic Navigation
    Marek Belohlavek; Fiscal Year: 2010
    ..We capitalize on our innovative working proto- type of an Acoustically Active Catheter (AAC): A tip of a steerable catheter is outfitted with a piezoelectric crystal that vibrates at a prescribed frequency and acts ..
  7. Miniaturized Distal Vibration System for Penetration of Vascular Occlusions
    STEPHANIE ADI HARRINGTON; Fiscal Year: 2010
    ..The vibrations at the guide wire tip provide additional penetrating force for active penetration through CTOs...
  8. Laser endoscopy for guided biopsy in the bile duct
    Eric J Seibel; Fiscal Year: 2010
    ..A new technology is proposed that puts a small microscanner at the tip of a catheter, making a rigid tip of only 9-mm and a rugged flexible shaft with a 6-mm bending radius...
  9. Precise Micro-Steerable Mapping and Ablation Catheters for Treatment of Atrial Fi
    DEAN A ANDERSON; Fiscal Year: 2010
    ..This is due to the lack of reproducibility and precision in controlling the catheter tip position by the push/pull cable in current catheters resulting in long procedure times (2 to 9 hrs), which risks ..
  10. OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surge
    Jin U Kang; Fiscal Year: 2013
    ..These will include a simple microinjection cannula that will allow assessment of tool tip position, tool-retina contact and depth of retinal penetration as well as to directly deliver therapeutic agents ..
  11. Ultrasound-assisted convection-enhanced drug delivery to the brain
    William L Olbricht; Fiscal Year: 2013
    ..We have developed a "smart needle" that is a CED infusion catheter containing a miniature transducer at its tip, which acts as a beacon for focusing ultrasound...
  12. Trans-illumination of visible light for real-time catheter visualization
    TIM W ROBINSON; Fiscal Year: 2011
    ..PICCs begin in a "peripheral" vein, typically in the arm or leg, and are then advanced through a vein until the tip of the catheter arrives at a "central" location (i.e...
  13. A Novel Approach to the Treatment of Cardiac Arrhythmia: A Robotic Catheter for E
    SHAPHAN REES JERNIGAN; Fiscal Year: 2011
    ..based controls to interpret joystick commands and to actuate the SMA tendons for accurate tracking of the commanded tip position...
  14. Fully Integrated Single Chip CMUT Arrays for Forward Looking IVUS and ICE
    FAHRETTIN L DEGERTEKIN; Fiscal Year: 2012
    ..by applicant): A highly flexible catheter with forward-looking, volumetric ultrasound imaging array at its tip would be invaluable for guiding interventions in totally occluded arteries and in the heart...
  15. Foley Urological Catheter Insertion Tool and Method
    THOMAS WILLIAM WINEGAR; Fiscal Year: 2011
    ..A proprietary lock mechanism near the tip of the catheter ensures that the pusher tube can not dislodge during the procedure...
  16. On-Chip Optofluidic Laser Scanning Confocal Microscope for Early Cancer Detection
    Tony Jun Huang; Fiscal Year: 2010
    ..of LSCM in early cancer diagnosis, it is necessary to develop miniature LSCM systems that can be fitted on the tip of an endoscope probe or catheter needle to facilitate high-resolution, minimally-invasive, in vivo confocal ..
  17. A Percutaneous Ultrasound-Guided Catheter for Organ and Vascular Access
    HYUNG HAM DAVID KIM; Fiscal Year: 2011
    ..In particular, studies will seek to demonstrate the device ability to track the device tip in real-time and guide it to specific targets in the gel phantom...
  18. Robotic System with Multiplexed DOF Control for Minimally Invasive Interventions
    Peter Kazanzides; Fiscal Year: 2012
    ..However, initial robotic alignment of the device toward its target can never completely eliminate tip placement error, because there is no means of compensation for registration error (which can never be completely ..
  19. Multi-lumen steerable needles for transoral access to lung nodules
    Ron Alterovitz; Fiscal Year: 2013
    ..Next, using image-guidance, the multi-lumen steerable needle will deploy from the bronchoscope's tip, pierce the bronchial tube, and maneuver through the parenchyma to the nodule...
  20. A Force-controlled Probe Based Platform for Single Cell Biomolecular Delivery
    HORACIO ESPINOSA; Fiscal Year: 2012
    ..e., high cell viability. Special probe morphology with a sharp tip that creates a small rupture in the cell membrane while the outer shell guides biomolecules to the point of ..
  21. MRI-Compatible Fiber-Optically Sensorized Biopsy Needles for Oncological Applicat
    BEHZAD MOSLEHI; Fiscal Year: 2013
    ..prototypical medical device treatment system capable of detecting and visualizing three dimensional shape and tip position of a biopsy needle during Magnetic Resonance Imaging (MRI) or other image-assisted interventional ..
  22. Development of OCT Imaging Adapter for Interstitial Tissue Imaging
    Ruikang Wang; Fiscal Year: 2013
    ..7,682,089, # 8,057,107, #8,235,602) provides revolutionary real-time forward imaging at the tip of any hollow bore needle or probe...
  23. Safe Flexible Intracerebral Navigation with Steerable Needles
    Cameron N Riviere; Fiscal Year: 2012
    ..There remain several unanswered needs, especially the development of means for tracking the tip of the flexible probe in vivo...
  24. Modular Ultrasonic Beacon System (MUBS) for Ultrasound-guided Interventional Surg
    Jay Mung; Fiscal Year: 2013
    ..Beacon System (MUBS) that consists mainly of a disposable, miniature hardware component to be incorporated with the tip or shaft of needles or other interventional tools...
  25. Combined Biophysical and Biochemical Study of Single Cells
    COREY P NEU; Fiscal Year: 2013
    ..through the implementation of a piezoelectric-based feedback mechanism for the deflection measurement of the AFM tip, which takes place when the tip is brought into contact with samples...
  26. New Probes and Reagents for AFM Studies
    JOHN KEANA; Fiscal Year: 2003
    ..the sample is placed on an atomically flat surface such as freshly cleaved mica and is raster scanned by a sharp tip mounted at the end of a flexible cantilever...
  27. New Probes and Reagents for AFM Studies
    JOHN KEANA; Fiscal Year: 2002
    ..the sample is placed on an atomically flat surface such as freshly cleaved mica and is raster scanned by a sharp tip mounted at the end of a flexible cantilever...
  28. ATTRACTIVE ATOMIC FORCE MICROSCOPY FOR DNA SEQUENCING
    JOSEPH BLANC; Fiscal Year: 1991
    ..views non-conducting surfaces at atomic resolution by measuring deflection of a lever with an atomically sharp tip. The small forces (10-13 to 10-8Newtons), and deflections (of the order of Angstroms) are measured using a ..
  29. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  30. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..Several intracellular PLA2s are expressed in heart, including cPLA2 and iPLA2 ...
  31. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2013
    ..This project's broad objective is to learn how genetic factors, interacting with the environment, can tip the balance towards one sex or another...
  32. The Role of MYST Histone Acetyltransferase in Genome Stability
    M Mitchell Smith; Fiscal Year: 2013
    ..We are investigating the molecular genetics of two signature members of the MYST family: the Esa1 enzyme of budding yeast, and the Myst2 enzyme of mouse and humans...
  33. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2011
    ..to receptors on resident macrophages resulting in a sustained increase in cytoplasmic calcium, activation of the cPLA2/5-lipoxygenase pathway and fatty acid binding protein-dependent leukotriene synthesis...
  34. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..To prove this hypothesis we will show that 1) GIT1 is required for angiogenesis by regulating tip cell functions (polarity, migration, and adhesion) via assembly of structures (podosomes, filopodia) dependent on ..
  35. Mechanism of Translation Elongation Factor 2 Inhibition by Bacterial Toxins
    Terri Goss Kinzy; Fiscal Year: 2010
    ..Saccharomyces cerevisiae, which is also modified by these toxins, demonstrates the diphthamide residue lies on the tip of domain IV of the protein...
  36. Molecular Studies of Bone Marrow Failure
    Monica Bessler; Fiscal Year: 2013
    ..and those of other investigators have shown that patients with the classic clinical features of DC are only the "tip of the iceberg" of individuals who have BMF due to defective telomere maintenance...
  37. Human cytomegalovirus entry into epithelial and endothelial cells
    David C Johnson; Fiscal Year: 2013
    ..Moreover, clinically recognized cases of HCMV in young children may represent only the "tip of the iceberg", many other infants with less well pronounced HCMV in utero may suffer more subtle developmental ..
  38. ANGIOTENSINS, PROSTAGLANDINS-ADRENERGIC INTERACTIONS
    Kafait U Malik; Fiscal Year: 2013
    ..is an extension of the previous work and is aimed to test the hypothesis that Group IV cytosolic phospholipase A2 (cPLA2[unreadable])plays a critical role in the pathogenesis of hypertension and hypertension- associated target-organ ..
  39. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara M Schreiber; Fiscal Year: 2010
    ..SAA induces expression of secretory phospholipase A2 (sPLA2) and calcium-dependent cytosolic phospholipase A2 (cPLA2). Moreover, we show that SAA dramatically increases expression of sPLA2 protein...
  40. Genetics of Age-Related Hearing Loss
    Kenneth R Johnson; Fiscal Year: 2013
    ..Cdh23 encodes a component of the stereocilia tip link, which is essential to hair cell mechanotransduction, but it is unclear how the Cdh23ahl variant influences ..
  41. Peripheral T Cell tolerance by targeting AKT
    Claudio Anasetti; Fiscal Year: 2010
    ..Depleting alloreactive T cells may tip the balance towards regulation and tolerance, if regulatory T cells (Tregs) are also spared...
  42. Prevention and Treatment of Chlorine Gas Induced Injury to the Pulmonary System
    Sadis Matalon; Fiscal Year: 2011
    ..such as albuterol (a long acting b-agonist) and a recently described peptide based on the lectin region of TNFa (tip peptide), shortly after exposure to C12 will decrease lung injury, morbidity and mortality...
  43. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..We recently identified TIP60 as a cell substrate of the protein kinases that is critical for herpesvirus replication...
  44. An Innovative Endoscopic Instrument with Full-Field Viewing and Intelligent Imagi
    STEVEN YI; Fiscal Year: 2010
    ..view, our equipment offers instant 360 degrees viewing images mechanically free, there is no need to bend the tip any more...
  45. ATF2 in DNA damage response.
    ZE apos EV A RONAI; Fiscal Year: 2010
    ..Earlier studies established ATF2 association with components of TIP60 histone acetyltransferase complex;ATF2 homologues in S...
  46. Mechanics of Inner Ear Hair Bundles
    KIRIAKI DOMENICA KARAVITAKI; Fiscal Year: 2012
    ..Using these measurements a silicon based V-shaped stimulation probe will be microfabricated and its tip will be coated with carbon nanotubes (CNTs) to promote adhesion of the probe to the cochlear bundles...
  47. Regulation and Function of the Matricellular Protein CCN1 in Ischemic Retinopathy
    Brahim Chaqour; Fiscal Year: 2013
    ..will identify interactions with Wnt- and Notch-derived signals known to influence functional specialization of ECs (tip and stalk cell phenotypes) and sprouting angiogenesis...
  48. MECHANISMS OF SALMONELLA INVASION AND TRANSMIGRATION
    James E Casanova; Fiscal Year: 2013
    ..SipC, which forms part of the tip of this apparatus, has long cytoplasmic N- and C-termini, which nucleate the assembly of actin filament networks ..
  49. MOLECULAR BASIS OF INHERITED DEAFNESS
    David P Corey; Fiscal Year: 2013
    ..of actin-based stereocilia arranged with increasing heights;each stereocilium of a cell extends a filamentous 'tip link'to the next taller stereocilium...
  50. Function of Microtubule Plus-End-Tracking Proteins in the Neuronal Growth Cone
    Laura Anne Lowery; Fiscal Year: 2013
    ..Initial work has identified +TIP XMAP215 and its co-factor Maskin as potent antagonists of the +TIP and Abl signaling substrate, CLASP...
  51. C. trachomatis-mediated signaling pathways required for Type I IFN responses
    JEFFREY RYAN BARKER; Fiscal Year: 2013
    ..Preliminary results show that the calcium-dependent phospholipase cPLA2 is required for Type I IFN induction in response to both C...
  52. Viral Gastroenteritis: Basis of Protection and Virulence
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    ..Recent studies in humans and animals demonstrated that RV infection is not limited to the mature epithelial tip cells of the small bowel but also occurs in other cells at other sites, including DCs...
  53. Endoplasmic reticulum structure and dynamics in breast cancer cell metastasis and
    JASON EDWARD LEE; Fiscal Year: 2013
    ..Additionally, ER dynamics along microtubules (MTs) have been characterized as tip- attachment complex (TAC) dynamics and ER sliding...
  54. Lipid Mediators in Corneal Nerve Regeneration
    Haydee E P Bazan; Fiscal Year: 2013
    ..PEDF acts through a mediated mechanism that activates cytosolic phospholipase A2/extracellular-regulated kinase (cPLA2/ERK1/2) signaling to release DHA for the synthesis of NPD1, which stimulates nerve growth factor (NGF) expression ..
  55. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    ..This grant seeks to understand the balance between these injurious and protective substances, to develop strategies which may tip the balance in favor of protecting transplanted lungs from lethal injury.
  56. Cellular and Biochemical Studies of Myosin Assembly in Dictyostelium
    Thomas Egelhoff; Fiscal Year: 2009
    ..system is regulated by phosphorylation/dephosphorylation of a set of mapped threonine residues that lie near the tip of the myosin tail...
  57. Microbial Invasion of the Intestine at the Cell Extrusion Zone of the Villus Tip
    Manuel R Amieva; Fiscal Year: 2012
    ..finds E-cadherin, its receptor for entry, at these sites and invades the gastrointestinal epithelium of the villus tip. We propose to establish an oral model of Listeria gastrointestinal infection in Guinea pigs to test this model by ..
  58. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
    ..of the Eya1 and Foxd1 genes as well as survival and renewal of MM cells;2) in the UB, HDAC1/2 maintain the pool of tip Ret+/Wnt11+ cells and repress the terminal differentiation program...
  59. Tau in cancer cells
    Gloria Lee; Fiscal Year: 2010
    ..cycle control in both age-related diseases, our ultimate aim is to determine if hyperphosphorylated tau is able to tip the balance in cell cycle control mechanisms towards cell division...
  60. Sensimmer Virtual Phaco Trainer for Cataract Surgery
    P Pat Banerjee; Fiscal Year: 2011
    ..g., Alcon) will be used, and the phaco foot pedal will control three modes of the virtual phaco tip: (1) irrigation;(2) irrigation + aspiration;(3) irrigation + aspiration + ultrasound power...
  61. Intraflagellar Transport Proteins in Mice
    Gregory J Pazour; Fiscal Year: 2013
    ..particles carry ciliary precursors from their site of synthesis in the cell body to their site of assembly at the tip of the cilium. We are interested in the function of the IFT particle proteins and have focused on the IFT20 subunit...
  62. Molecular roles in active and passive mechanics in cochlear hair bundles
    ANTHONY WEI PENG; Fiscal Year: 2013
    ..This data will be used to generate new models of cochlear MET. Myosin motors localized to the upper tip-link region have been proposed to be important to MET...
  63. Airway Navigational System
    JENELLE GANATRA; Fiscal Year: 2007
    ..Also in phase I, we will begin to implement optical tracking of the endoscope tip as the foundation for our phase II hybrid system which will combine both magnetic and optical tracking into a ..
  64. 14 3 3 Implications in Topoisomerase II Pharmacology
    David Kroll; Fiscal Year: 2003
    ..A human homolog of the yeast TIP, Sgsl, is likely to be the gene that when mutated is responsible for the high tumor frequency in Bloom's syndrome ..
  65. Modulation of c-MYC Functions in an HTLV-1 Model for Carcinogenesis
    Robert Harrod; Fiscal Year: 2009
    ..preliminary studies demonstrate that p30II enhances c-MYC-dependent transactivation through interactions with the TIP60 acetyltransferase. HTLV-1 p30II induces Lys- acetylation of c-MYC...
  66. PHYSIOLOGIC PHOSPHOLIPASE A2 ACTIVATION IN NEUTROPHILS
    SUE BAULDRY; Fiscal Year: 2000
    ..production of LTB4 and PAF and demonstration that PMN contain two calcium-dependent PLA2/s, a "cytosolic" enzyme, cPLA2, and a "secretory" enzyme, sPLA2, has led to intense interest in determining whether one or both are responsible ..
  67. Characterization of Endpoint Mechanical Actions of Thumb Muscles
    Joseph D Towles; Fiscal Year: 2011
    ..with no strong evidence that they are optimally designed to restore large, appropriately-directed thumb-tip force vectors necessary for stable grasps. Surgical outcomes have been mixed...
  68. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009
    ..In the amnion fibroblasts, we have shown glucocorticoids increase PGE2 synthesis by up-regulation of cPLA2 and PGHS-2 enzymes...
  69. REGULATION AND FUNCTION OF CPLA2 IN UV INJURY
    Alice Pentland; Fiscal Year: 2000
    ..Recent work in our laboratory suggests that cytosolic phospholipase A2 (cPLA2) is an active participant in this process. cPLA2 is a recently described high molecular weight phospholipase...
  70. Telephone Counseling to Manage GnRH Agonist Symptom Clusters in Black Men w/ PCa
    ERNEST BENNETT; Fiscal Year: 2009
    ..We propose testing a Telephone Interpersonal Counseling (TIP-C) symptom management intervention...