TIMP-3

Summary

Gene Symbol: TIMP-3
Description: TIMP metallopeptidase inhibitor 3
Alias: HSMRK222, K222, K222TA2, SFD, metalloproteinase inhibitor 3, MIG-5 protein, TIMP-3, protein MIG-5, tissue inhibitor of metalloproteinases 3
Species: human

Top Publications

  1. ncbi A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
    Jian Hua Qi
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Nat Med 9:407-15. 2003
  2. doi Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice
    Loredana Fiorentino
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Hepatology 51:103-10. 2010
  3. pmc Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3
    Thomas Neill
    Department of Pathology, Anatomy and Cell Biology, the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 287:5492-506. 2012
  4. ncbi Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations
    Philip A Klenotic
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 279:30469-73. 2004
  5. doi Human chorionic gonadotropin stimulates matrix metalloproteinases-2 and -9 in cytotrophoblastic cells and decreases tissue inhibitor of metalloproteinases-1, -2, and -3 in decidualized endometrial stromal cells
    Herbert Fluhr
    Department of Obstetrics and Gynecology, University of Greifswald, Greifswald, Germany
    Fertil Steril 90:1390-5. 2008
  6. ncbi Association of a high activity of matrix metalloproteinase-9 to low levels of tissue inhibitors of metalloproteinase-1 and -3 in human hepatitis B-viral hepatoma cells
    Jeong Ran Kim
    National Research Laboratory for Glycobiology, Ministry of Science and Technology and Department of Biochemistry and Molecular Biology, Dongguk University COM, Kyungbuk 780 714, South Korea
    Int J Biochem Cell Biol 36:2293-306. 2004
  7. pmc Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1
    Simone D Scilabra
    Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 288:332-42. 2013
  8. ncbi The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3
    H Will
    In Vitek GmbH, Robert Roessle Strasse 10, D 13125 Berlin Buch, Federal Republic of Germany
    J Biol Chem 271:17119-23. 1996
  9. ncbi Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Stroke 34:2817-21. 2003
  10. ncbi Pseudoinflammatory fundus dystrophy with autosomal recessive inheritance
    H R Forsius
    Am J Ophthalmol 94:634-49. 1982

Research Grants

  1. Inducible Macrophage Specific Gene Expression in Diseases
    JEANINE M D apos ARMIENTO; Fiscal Year: 2010
  2. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
  3. Role of IGF-II in Human Trophoblast-Decidua Interactions
    Linda Giudice; Fiscal Year: 2006
  4. REGULATION OF RETINAL NEOVASCULARIZATION BY TIMP3
    Bela Anand Apte; Fiscal Year: 2002
  5. Stuart J Frank; Fiscal Year: 2016
  6. Regulation of Skeletal Muscle Regeneration
    Yi Ping Li; Fiscal Year: 2012
  7. Epigenetic changes predict disease course of HPV-related lesions in women 16-24
    NANCY B contact KIVIAT; Fiscal Year: 2010
  8. The Incidence and Progression of Peripheral Venous Disease
    Michael H Criqui; Fiscal Year: 2010
  9. Role of TIMP-3 in Ocular Neovascularization
    Bela Anand Apte; Fiscal Year: 2009
  10. Methylation in Cancer Progression of Barrett's Esophagus
    Jean S Wang; Fiscal Year: 2010

Detail Information

Publications217 found, 100 shown here

  1. ncbi A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
    Jian Hua Qi
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Nat Med 9:407-15. 2003
    ..This property seems to be independent of its MMP-inhibitory activity, indicating a new function for this molecule...
  2. doi Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice
    Loredana Fiorentino
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Hepatology 51:103-10. 2010
    ..All these proteins play a role in fatty acid uptake, triglyceride synthesis, and methionine metabolism, providing a molecular explanation for the increased hepatosteatosis observed in Timp3(-/-) compared with WT mice...
  3. pmc Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3
    Thomas Neill
    Department of Pathology, Anatomy and Cell Biology, the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 287:5492-506. 2012
    ..Our data establish a novel duality for decorin as a suppressor of tumor angiogenesis under normoxia by simultaneously down-regulating potent pro-angiogenic factors and inducing endogenous anti-angiogenic agents...
  4. ncbi Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations
    Philip A Klenotic
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 279:30469-73. 2004
    ..Mutations in the Timp-3 gene cause Sorsby fundus dystrophy (SFD), a hereditary macular degenerative disease...
  5. doi Human chorionic gonadotropin stimulates matrix metalloproteinases-2 and -9 in cytotrophoblastic cells and decreases tissue inhibitor of metalloproteinases-1, -2, and -3 in decidualized endometrial stromal cells
    Herbert Fluhr
    Department of Obstetrics and Gynecology, University of Greifswald, Greifswald, Germany
    Fertil Steril 90:1390-5. 2008
    ..To investigate the influence of hCG on trophoblastic matrix metalloproteinases (MMPs) -2 and -9 as well as endometrial tissue inhibitor of metalloproteinases (TIMPs) -1, -2, and -3...
  6. ncbi Association of a high activity of matrix metalloproteinase-9 to low levels of tissue inhibitors of metalloproteinase-1 and -3 in human hepatitis B-viral hepatoma cells
    Jeong Ran Kim
    National Research Laboratory for Glycobiology, Ministry of Science and Technology and Department of Biochemistry and Molecular Biology, Dongguk University COM, Kyungbuk 780 714, South Korea
    Int J Biochem Cell Biol 36:2293-306. 2004
    ..Based on these results, it is concluded that HBV affects the malignance of hepatocellular cancer by elevating MMP-9 activity, and suppressing TIMP-1 and TIMP-3...
  7. pmc Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1
    Simone D Scilabra
    Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 288:332-42. 2013
    ..Extracellular levels of sLRP-1 can thus increase the half-life of TIMP-3 in the extracellular space, controlling the bioavailability of TIMP-3 to inhibit metalloproteinases...
  8. ncbi The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3
    H Will
    In Vitek GmbH, Robert Roessle Strasse 10, D 13125 Berlin Buch, Federal Republic of Germany
    J Biol Chem 271:17119-23. 1996
    ..These data demonstrate the basic mechanism of MT1-MMP action on progelatinase A and the reason for the lack of inhibition by TIMP-1 previously demonstrated in cell-based activation studies...
  9. ncbi Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Stroke 34:2817-21. 2003
    ..Their activity is controlled predominantly by tissue inhibitors of metalloproteinases (TIMPs). To investigate the possible impact of genetic variants within the genes encoding TIMP-1, -2, and -3, we conducted this case-control study...
  10. ncbi Pseudoinflammatory fundus dystrophy with autosomal recessive inheritance
    H R Forsius
    Am J Ophthalmol 94:634-49. 1982
    ..The affected parents are consanguineous in many ways and each of their eight children is affected...
  11. ncbi Night blindness in Sorsby's fundus dystrophy reversed by vitamin A
    S G Jacobson
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Florida 33136, USA
    Nat Genet 11:27-32. 1995
    Sorsby's fundus dystrophy (SFD) is an autosomal dominant retinal degeneration caused by mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) gene. Mechanisms of the visual loss in SFD, however, remain unknown...
  12. ncbi Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy
    B H Weber
    Institut fur Humangenetik, Biozentrum, Wurzburg, Germany
    Nat Genet 8:352-6. 1994
    ..Among these disorders, Sorsby's fundus dystrophy (SFD), an autosomal dominant condition, provides an excellent mendelian model for the study of the genetically complex ..
  13. pmc The tissue inhibitor of metalloproteinases-3 gene in breast carcinoma: identification of multiple polyadenylation sites and a stromal pattern of expression
    J A Byrne
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    Mol Med 1:418-27. 1995
    ..Tissue inhibitor of metalloproteinases-3 (TIMP3) is the third member of the TIMP family of proteins, believed to play a significant role in controlling extracellular matrix remodeling...
  14. ncbi A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features
    U Felbor
    Insitut für Humangenetik, Unversität Würzburg, Germany
    Hum Mol Genet 4:2415-6. 1995
  15. ncbi Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3)
    H Stohr
    Genome Res 5:483-7. 1995
    ..recently, we have shown that mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy (SFD). This is a macular degeneration disorder with characteristic ECM irregularities in Bruch's membrane...
  16. ncbi Localization of the functional domains of human tissue inhibitor of metalloproteinases-3 and the effects of a Sorsby's fundus dystrophy mutation
    K P Langton
    Krebs Institute for Biomolecular Research, Department of Pathology, University of Sheffield, Medical School, Sheffield S10 2RX, United Kingdom
    J Biol Chem 273:16778-81. 1998
    ..These data favor the hypothesis that the TIMP-3 mutations seen in Sorsby's fundus dystrophy contribute to disease progression by accumulation of mutant protein rather than by the loss of functional TIMP-3...
  17. ncbi A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in Sorsby's fundus dystrophy
    K P Langton
    Division of Oncology and Cellular Pathology, Pathology Section, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, United Kingdom
    J Biol Chem 275:27027-31. 2000
    Sorsby's fundus dystrophy (SFD) is a dominantly inherited degenerative disease of the retina that leads to loss of vision in middle age...
  18. ncbi Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis
    Jian Hua Qi
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:13394-400. 2002
    Sorsby's fundus dystrophy (SFD) is an autosomal dominant degenerative disease of the macula caused by mutations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) gene...
  19. ncbi Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix
    Karen M Yeow
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk NR4 7TJ, UK
    Matrix Biol 21:75-88. 2002
    ..Mutations in the TIMP3 gene have been linked to Sorsby's fundus dystrophy (SFD), an autosomal dominant inherited retinal degenerative disease that leads to blindness...
  20. ncbi Novel mutation in the TIMP3 gene causes Sorsby fundus dystrophy
    Samuel G Jacobson
    Scheie Eye Institute, 51 N 39th St, Philadelphia, PA 19104, USA
    Arch Ophthalmol 120:376-9. 2002
    ..To determine the molecular basis of a retinopathy previously described as dominant macular subretinal neovascularization with peripheral retinal degeneration...
  21. ncbi Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors
    Matti Ahonen
    Centre for Biotechonology, University of Turku, Finland
    Oncogene 22:2121-34. 2003
    ..Taken together, these results show that TIMP-3 promotes apoptosis in melanoma cells through stabilization of three distinct death receptors and activation of their apoptotic signaling cascade through caspase-8...
  22. ncbi Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development
    Pieter A van der Velden
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Cancer 106:472-9. 2003
    ..We demonstrate in the cell lines that TIMP3 expression is regulated by methylation. These observations were confirmed in primary uveal melanoma and suggests a role for TIMP3 in uveal melanoma development...
  23. ncbi Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas
    Dev Karan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA
    Int J Oncol 23:1365-71. 2003
    ..These results suggest that an inverse expression pattern of ADAM-17/TACE and TIMP-3, and the regulation of ADAMs with DHT might play an important role in the pathogenesis of prostate cancer...
  24. ncbi Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma
    Huichen Feng
    Department of Anatomy, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Gynecol Oncol 94:375-82. 2004
    ..To assess the differential gene expression in neoplastic and normal trophoblastic cells and evaluate the effect of methylation on tissue inhibitor of metalloproteinase 3 (TIMP3) expression in choriocarcinoma (CCA) cells...
  25. ncbi Expression of TIMP-3 gene by construction of a eukaryotic cell expression vector and its role in reduction of metastasis in a human breast cancer cell line
    Xichun Han
    Department of Gerenal Surgery, The Second Hospital of Jilin University, Changchun 130041, China
    Cell Mol Immunol 1:308-10. 2004
    ..Our experiments further indicated that the potential of metastasis was significantly reduced for the transfected cell line MDA-MB-453...
  26. ncbi TIMP3 mutation in Sorsby's fundus dystrophy: molecular insights
    Zheng Li
    Henry Wellcome Laboratory for Biogerontology Research, Newcastle General Hospital, Newcastle, NE4 6BH, UK
    Expert Rev Mol Med 7:1-15. 2005
    ..a role, SFD has been shown to be a single-gene disorder, linked to mutations in exon 5 of the tissue inhibitor of metalloproteinases 3 (TIMP3) gene on chromosome 22q12-q13...
  27. ncbi Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer
    Shuiying Hu
    Department of Medicine, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Cancer 119:2322-9. 2006
    ..These results suggest that aberrant methylation and hence silencing of TIMP3, SLC5A8, DAPK and RARbeta2, in association with BRAF mutation, may be an important step in PTC tumorigenesis and progression...
  28. ncbi Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1
    Meng Huee Lee
    Department of Oncology, Cancer Research UK Cambridge Research Institute, Cambridge University, Cambridge CB2 0RE, United Kingdom
    J Biol Chem 282:6887-98. 2007
    ..This is the first instance of TIMPs being intentionally rendered soluble or ECM-bound. The ability to prepare TIMPs in soluble or ECM-bound forms also opens new avenues for future TIMP research...
  29. ncbi Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma
    Chetan S Nayak
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0910, USA
    Laryngoscope 117:1376-80. 2007
    ....
  30. pmc Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma
    Yu Xian Bai
    Department of Medicine, Affiliated Tumor Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
    World J Gastroenterol 13:3883-5. 2007
    ..To explore the expression of BAG1 and tissue inhibitor of metalloproteinase 3 (TIMP3) in colon carcinoma and their correlation and clinicopathologic significance...
  31. ncbi Oxidised, glycated LDL selectively influences tissue inhibitor of metalloproteinase-3 gene expression and protein production in human retinal capillary pericytes
    J L Barth
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC, USA
    Diabetologia 50:2200-8. 2007
    ....
  32. ncbi TIMP-3 gene transfection suppresses invasive and metastatic capacity of human hepatocarcinoma cell line HCC-7721
    Hong Zhang
    Department of General Surgery, Second Hospital of Jilin University, Changchun 130041, China
    Hepatobiliary Pancreat Dis Int 6:487-91. 2007
    ..There are currently four known TIMP family members-TIMP-1, 2, 3, 4. We determined whether increasing levels of TIMP-3 expression could suppress the malignant phenotype of human hepatocarcinoma cell line HCC-7721...
  33. ncbi Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness
    Christine Armstrong
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, Tooting, London, UK
    Stroke 38:2895-9. 2007
    ..We have therefore sought to address this issue in a large, well-phenotyped community population to assess the effect of a number of polymorphisms in both MMP and TIMP genes on carotid artery intima-media thickness (IMT)...
  34. doi Tissue inhibitor of metalloproteinases-3 interacts with angiotensin II type 2 receptor and additively inhibits angiogenesis
    Kyo Hwa Kang
    Molecular Therapy Research Center, Sungkyunkwan University, Samsung Medical Center Annex 8F, 50, IlWon Dong, Seoul 135 710, Republic of Korea
    Cardiovasc Res 79:150-60. 2008
    ..Previous data have shown that TIMPs bind tightly to most matrix metalloproteinases, although the pathway that mediates angiostatic activity has not been fully established...
  35. doi Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes
    Hamid Yaqoob Qureshi
    Department of Medicine, University of Montreal and Research Centre of Centre Hospitalier de l Université de Montréal CR CHUM, K 5255 Mailloux, Notre Dame Hospital, 1560 Sherbrooke E, Montreal, Quebec, Canada H2L 4M1
    Biochim Biophys Acta 1783:1605-12. 2008
    ..These results suggest that receptor-activated Smad2 and Smad3 and co-Smad4 critically mediate TGF-beta-stimulated TIMP-3 expression in human chondrocytes and TIMP-3 gene is a target of Smad signaling pathway...
  36. pmc Low tissue inhibitor of metalloproteinases 3 and high matrix metalloproteinase 14 levels defines a subpopulation of highly invasive foam-cell macrophages
    Jason L Johnson
    Bristol Heart Institute, University of Bristol, England
    Arterioscler Thromb Vasc Biol 28:1647-53. 2008
    ..An excess of metalloproteinases (MMPs) over tissue inhibitors of metalloproteinases (TIMPs) may favor atherosclerotic plaque rupture. We compared TIMP levels in nonfoamy and foam-cell macrophages (FCM) generated in vivo...
  37. doi Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex
    Magdalena Wisniewska
    Max Planck Institut fur Biochemie, Proteinase Research Group, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Mol Biol 381:1307-19. 2008
    TIMP-3 (tissue inhibitor of metalloproteinases 3) is unique among the TIMP inhibitors, in that it effectively inhibits the TNF-alpha converting enzyme (TACE)...
  38. ncbi Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only
    H De Schutter
    Leuvens Kanker Instituut, UH Leuven Campus Gasthuisberg, 3000 Leuven, Belgium
    Oncol Rep 21:507-13. 2009
    ..12 and p=0.007, respectively). In conclusion, in this representative group of 46 patients with advanced HNSCC treated by radiotherapy only, the epigenetic silencing of TIMP3 and CDH1 predicted a better outcome...
  39. pmc Loss of TIMP3 enhances interstitial nephritis and fibrosis
    Zamaneh Kassiri
    Department of Physiology, Cardiovascular Research Group, Room 474, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, T6G 2S2 Canada
    J Am Soc Nephrol 20:1223-35. 2009
    ..Taken together, these results provide evidence that TIMP3 is an important mediator of kidney injury, and regulating its activity may have therapeutic benefit for patients with kidney disease...
  40. pmc Polymorphisms in tissue inhibitors of metalloproteinases-2 and -3 and breast cancer susceptibility and survival
    Neeraja B Peterson
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Int J Cancer 125:844-50. 2009
    ..Genetic variation in the TIMP-2 and TIMP-3 genes may contribute to individual differences in breast cancer susceptibility and survival...
  41. doi Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins
    Ozlem Darcansoy Iseri
    Department of Biological Sciences, Middle East Technical University, 06531, Ankara, Turkey
    Cancer Chemother Pharmacol 65:447-55. 2010
    ....
  42. pmc TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1
    Marina Cardellini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes 58:2396-401. 2009
    ..We tested its association with atherosclerosis in subjects with type 2 diabetes and identified Sirtuin 1 (SirT1) as a major regulator of TIMP3 expression...
  43. pmc Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia
    Sonja Röhrs
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Mol Cancer 8:86. 2009
    ..Here, we aimed to relate MLL mutational status and tumor suppressor gene (TSG) methylation/expression in acute leukemia cell lines...
  44. pmc miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
    Michela Garofalo
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 16:498-509. 2009
    ..Finally, we demonstrate that the MET oncogene is involved in miR-221&222 activation through the c-Jun transcription factor...
  45. pmc MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression
    Bao Song
    Provincial Key Laboratory of radiation oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China
    J Exp Clin Cancer Res 29:29. 2010
    ....
  46. pmc Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    Wei Chen
    Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:7401-6. 2010
    ..Our studies extend the catalog of AMD associated loci, help identify individuals at high risk of disease, and provide clues about underlying cellular pathways that should eventually lead to new therapies...
  47. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD...
  48. pmc Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression
    J W Kornfeld
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Br J Cancer 104:138-45. 2011
    ..TACE-dependent proteolysis is regulated by its inhibitor, tissue inhibitor of metalloproteinases 3 (TIMP3)...
  49. doi TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells
    M C Anania
    Molecular Mechanisms Unit, IRCCS Foundation Istituto Nazionale dei Tumori, Milan, Italy
    Oncogene 30:3011-23. 2011
    ..Our data indicate that the loss of TIMP3 expression exerts a functional role in the pathogenesis of PTC...
  50. pmc Detection of TIMP3 promoter hypermethylation in salivary rinse as an independent predictor of local recurrence-free survival in head and neck cancer
    Wenyue Sun
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Cancer Res 18:1082-91. 2012
    ....
  51. doi Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines
    Sharon L Turner
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK
    Int J Oncol 41:1043-9. 2012
    ..The pro-inflammatory cytokines IL-1β, TNF-α or IL-6 induced changes in mRNA expression, although these did not translate to the protein level...
  52. doi Loss of TIMP-3 promotes tumor invasion via elevated IL-6 production and predicts poor survival and relapse in HPV-infected non-small cell lung cancer
    De Wei Wu
    Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taiwan
    Am J Pathol 181:1796-806. 2012
    ....
  53. doi Prognostic significance of TIMP3 hypermethylation in post-treatment salivary rinse from head and neck squamous cell carcinoma patients
    Marianna Marconato Rettori
    Department of Biological Science, Federal University of Sao Paulo, 04039 032, Sao Paulo, Brazil
    Carcinogenesis 34:20-7. 2013
    ....
  54. pmc Multivalent pseudopeptides targeting cell surface nucleoproteins inhibit cancer cell invasion through tissue inhibitor of metalloproteinases 3 (TIMP-3) release
    Damien Destouches
    Universite Paris Est, Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires CRRET, CNRS, 61 Avenue du General de Gaulle, 94010 Creteil, France
    J Biol Chem 287:43685-93. 2012
    ....
  55. doi MiR-21 down-regulation suppresses cell growth, invasion and induces cell apoptosis by targeting FASL, TIMP3, and RECK genes in esophageal carcinoma
    Na Wang
    College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China
    Dig Dis Sci 58:1863-70. 2013
    ..The target gene of miR-21 including FASL, TIMP3 and RECK is revealed by researchers. miR-21 may be involved in the tumorgenesis of ESCC by targeting FASL, TIMP3 and RECK...
  56. pmc Genetic polymorphisms at TIMP3 are associated with survival of adenocarcinoma of the gastroesophageal junction
    Morteza Bashash
    Cancer Control Research Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    PLoS ONE 8:e59157. 2013
    ..TIMP3 genetic variants are associated with survival and may be potentially useful in optimizing treatment strategies for individual patients...
  57. pmc Promoter methylation and expression of TIMP3 gene in gastric cancer
    Zhiyu Guan
    Department of Cardiovascular and Thoracic Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, HePing Section, Tianjin 300052, China
    Diagn Pathol 8:110. 2013
    ....
  58. pmc Integrin α7 binds tissue inhibitor of metalloproteinase 3 to suppress growth of prostate cancer cells
    Lang Zhu Tan
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 183:831-40. 2013
    ..As a result, this report demonstrates a novel and critical signaling mechanism of ITGA7, through the TIMP3/NF-κB/cyclin D1 pathway. ..
  59. pmc A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice
    Yung Yi Chen
    Department of Oncology, Medical School, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK
    Angiogenesis 17:207-19. 2014
    ..This multiple-receptor inhibition may explain why the peptide was also seen to be a powerful inhibitor of tumour growth and also a partial inhibitor of arthritic joint inflammation in vivo. ..
  60. doi EZH2 regulates cancer cell migration through repressing TIMP-3 in non-small cell lung cancer
    Chunhua Xu
    First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, 210029, Jiangsu, China
    Med Oncol 30:713. 2013
    ..Taken together, our findings indicate that EZH2 accelerates cancer cell migration, in part, via the repression of TIMP-3 expression, suggesting a potential mechanism by which EZH2 promotes lung cancer progression and metastasis...
  61. doi Differential TIMP3 expression affects tumor progression and angiogenesis in melanomas through regulation of directionally persistent endothelial cell migration
    Asha M Das
    Laboratory Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus Medical Center, Room Ee 0104a, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Angiogenesis 17:163-77. 2014
    ..Taken together, our results demonstrate that TIMP3 expression correlates with inhibition of directionally persistent EC migration and adversely affects the angiogenic potential and growth of melanomas. ..
  62. ncbi The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family
    S S Apte
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 270:14313-8. 1995
    ..Instead, differential regulation of the TIMP genes or divergent C-terminal protein sequences may underlie distinct biological functions for each TIMP...
  63. ncbi The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican
    N A Cross
    Academic Urology Unit, Division of Clinical Sciences South, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Prostate 63:269-75. 2005
    ..These enzymes have one major inhibitor in the ECM, tissue inhibitor of metalloproteinases (TIMP)-3...
  64. ncbi Tissue inhibitor of metalloproteinase-3 (TIMP-3) gene is methylated in the development of esophageal adenocarcinoma: loss of expression correlates with poor prognosis
    S Jane Darnton
    Oesophageal Research Laboratory, Department of Thoracic Surgery, Birmingham Heartlands Hospital, Birmingham, United Kingdom
    Int J Cancer 115:351-8. 2005
    ..These studies have demonstrated association between methylation of the TIMP-3 gene and BE and EADC. Reduced expression of TIMP-3 protein in EADC is associated with increased tumour invasiveness and reduced patient survival...
  65. ncbi A novel TIMP3 mutation associated with Sorsby fundus dystrophy
    Irene A Barbazetto
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Arch Ophthalmol 123:542-3. 2005
  66. ncbi Sorsby's fundus dystrophy mutations impair turnover of TIMP-3 by retinal pigment epithelial cells
    Kevin P Langton
    Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield, Sheffield S10 1EW, UK
    Hum Mol Genet 14:3579-86. 2005
    Sorsby's fundus dystrophy (SFD) is an autosomal dominant degenerative disease of the retina, caused by mutations in exon 5 of the gene for tissue inhibitor of metalloproteinases-3 (TIMP-3)...
  67. ncbi A novel His158Arg mutation in TIMP3 causes a late-onset form of Sorsby fundus dystrophy
    Ruth J Lin
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Am J Ophthalmol 142:839-48. 2006
    To describe the phenotype and genotype of a family with suspected Sorsby fundus dystrophy (SFD).
  68. ncbi TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4
    Gareth J Wayne
    GlaxoSmithKline, New Frontiers Research Park, Harlow, Essex CM19 5AW, United Kingdom
    J Biol Chem 282:20991-8. 2007
    ..The results of this study therefore indicate that the cartilage environment can modulate the function of enzyme-inhibitor systems and could have relevance for therapeutic approaches to aggrecanase modulation...
  69. ncbi Quantitative detection of TIMP-3 promoter hypermethylation and its prognostic significance in esophageal squamous cell carcinoma
    Itasu Ninomiya
    Gastroenterologic Surgery, Department of Oncology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Ishikawa 920 8641, Japan
    Oncol Rep 20:1489-95. 2008
    ..0357). These results demonstrate that TIMP-3 hypermethylation is associated with lower TIMP-3 protein expression in ESCC and with poor patient survival due to a high frequency of recurrence by pleural dissemination...
  70. pmc MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3
    Florin M Selaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hepatology 49:1595-601. 2009
    ..995. Inhibitors of miR-21 increased protein levels of programmed cell death 4 (PDCD4) and tissue inhibitor of metalloproteinases 3 (TIMP3). Notably, messenger RNA levels of TIMP3 were significantly lower in CCAs than in normals.
  71. doi Catalytically inactive phospholipase A2 homologue binds to vascular endothelial growth factor receptor-2 via a C-terminal loop region
    Daisuke Fujisawa
    Department of Biochemistry, Meiji Pharmaceutical University, 2 522 1 Kiyose, Tokyo 204 8588, Japan
    Biochem J 411:515-22. 2008
    ..The results of the present study provide insight into the binding of inactive PLA(2) homologues to KDR, and may also assist in the design of novel anti-KDR molecules for anti-angiogenic therapy...
  72. ncbi Tissue inhibitor of matrix metalloproteinase-3 expression in the mouse uterus during implantation and artificially induced decidualization
    B M Bany
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    Mol Reprod Dev 59:159-67. 2001
    ....
  73. ncbi Matrix metalloproteinase inhibition facilitates cell death in intracerebral hemorrhage in mouse
    Mark Grossetete
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 28:752-63. 2008
    ..Our results fail to implicate TIMP-3 in apoptosis in CIH, but show that BB-94 increased apoptosis in CIH, possibly by blocking shedding of TNF death receptors and/or their ligands...
  74. ncbi Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma
    Martine L M Lamfers
    Department of Neurosurgery, Division of Gene Therapy, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Res 65:9398-405. 2005
    ..However, expression of TIMP-3 in the context of AdDelta24 did not significantly affect the antitumor efficacy of this oncolytic agent...
  75. ncbi Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3?
    Nicolas Pottier
    IPMC, CNRS UMR6097, 660, route des Lucioles, F06560 Sophia Antipolis, France
    Am J Respir Crit Care Med 176:1098-107. 2007
    ..Different sensitivities to profibrotic compounds such as bleomycin are observed among mouse strains...
  76. ncbi Autosomal dominant hemorrhagic macular dystrophy not associated with the TIMP3 gene
    R Ayyagari
    W K Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
    Arch Ophthalmol 118:85-92. 2000
    ..To describe the ophthalmic and genetic findings of a large kindred (UM:H389) with autosomal dominant hemorrhagic macular dystrophy...
  77. ncbi Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry
    Koichiro Nishino
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Dev Growth Differ 44:35-43. 2002
    ..These findings are an important clue for the elucidation of testicular formation in developing gonads...
  78. ncbi Matrix revolution: molecular mechanism for inflammatory corneal neovascularization and restoration of corneal avascularity by epithelial stem cell transplantation
    David Hui Kang Ma
    Limbal Stem Cell Laboratory, Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Ocul Surf 7:128-44. 2009
    ..Taken together, the merits of enhanced anti-angiogenic activity and the preservation of corneal epithelial stem cells encourage further application of this tissue engineering technique for ocular surface reconstruction...
  79. doi PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage
    S Otsuka
    Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Osteoarthritis Cartilage 17:529-38. 2009
    ..The effect of the prostaglandin E2 (PGE2) signal through prostaglandin E receptor 2 (EP2) receptors on the repair of injured articular cartilage was investigated using a selective agonist for EP2...
  80. doi Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice
    Rossella Menghini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Gastroenterology 136:663-72.e4. 2009
    ....
  81. ncbi Expression of tissue inhibitor of metalloproteinase-3 (TIMP-3) and its prognostic significance in resected non-small cell lung cancer
    Nobuya Mino
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Surg Oncol 95:250-7. 2007
    ..We conducted a retrospective study of TIMP-3 expression in resected non-small cell lung cancer (NSCLC)...
  82. ncbi Tissue inhibitor of metalloproteinase-3 deficiency inhibits blood pressure elevation and myocardial microvascular remodeling induced by chronic administration of Nomega-nitro-L-arginine methyl ester in mice
    Masayoshi Higuchi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 30:563-71. 2007
    ..Our findings suggest that Timp-3 may be a novel therapeutic target for the treatment of hypertension and consequent organ damage...
  83. pmc Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart
    Zamaneh Kassiri
    Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G2M9, Canada
    J Biol Chem 284:29893-904. 2009
    ..Thus, TIMP3 is a common innate regulator of TGFbeta1 and TNF in tissue response to injury. The matrix-bound TIMP3 balances the anti-inflammatory and proinflammatory processes toward constructive tissue remodeling...
  84. ncbi CpG island methylation in premalignant stages of gastric carcinoma
    G H Kang
    Department of Pathology, Seoul National University College of Medicine and Cancer Research Institute, Korea
    Cancer Res 61:2847-51. 2001
    ..001) as well as from premalignant lesions to carcinomas (P = 0.002). These results suggest that CpG island hypermethylation occur early in multistep gastric carcinogenesis and tend to accumulate along the multistep carcinogenesis...
  85. ncbi Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos
    E J Whiteside
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
    Biol Reprod 64:1331-7. 2001
    ..MMP-9 is expressed by the embryo's trophoblast cells, whereas tissue inhibitor of metalloproteinases 3 (TIMP-3) is expressed by the maternal uterine cells immediately adjacent to the trophoblast...
  86. ncbi Effect of superovulation on the expression of tissue inhibitor of metalloproteinase-3 in the murine endometrium
    Seung Yup Ku
    Department of Obstetrics and Gynecology, Seoul National University, Seoul, South Korea
    Gynecol Obstet Invest 55:1-6. 2003
    ....
  87. pmc Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha
    Massimo Federici
    Center for Atherosclerosis, Policlinico Tor Vergata University Hospital, Rome, Italy
    J Clin Invest 115:3494-505. 2005
    ..Our results suggest that an interplay between reduced insulin action and unchecked TACE activity promotes diabetes and vascular inflammation...
  88. ncbi Tissue inhibitor of metalloproteinase-3 plays important roles in the kidney following unilateral ureteral obstruction
    Hidenobu Kawamoto
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Hypertens Res 29:285-94. 2006
    ..These findings indicate that Timp-3-deficiency does not substantially affect the blood pressure in mice, and that Timp-3 plays an important role in the maintenance of renal macrostructure after unilateral ureteral obstruction...
  89. pmc Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas
    Bo Lin Liu
    Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, West Changle Road, No 127, Xi an, Shaanxi Province 710032, People s Republic of China
    Neuro Oncol 12:540-8. 2010
    ..Evaluation of these changes may help in selecting glioma patients for optimal adjuvant treatments and modifying chemotherapy...
  90. ncbi Molecular genetics of macular degeneration
    M A Musarella
    Long Island College Hospital, Department of Ophthalmology, Brooklyn, NY 11231, USA
    Doc Ophthalmol 102:165-77. 2001
    ....
  91. pmc Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer
    Chandramu Chetty
    Program of Cancer Biology, Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA
    Cancer Res 68:4736-45. 2008
    ..These experiments provide the first evidence that inhibition of p-AKT and induction of p-ERK1/2 are crucial events in the induction of TIMP-3-mediated endothelial apoptosis in MMP-2 inhibited lung tumors...
  92. doi Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling
    Lamis Hammoud
    Department of Physiology, Univ of Western Ontario, London, Ontario, Canada N6A 5C1
    Am J Physiol Cell Physiol 296:C735-45. 2009
    ..We conclude that TIMP-3 inhibits neonatal mouse cardiomyocyte proliferation by upregulating p27 expression. The effects of TIMP-3 are mediated via inhibition of EGFR expression/phosphorylation, and decreases in JNK and SP-1 signaling...
  93. doi Hypermethylation and transcriptional downregulation of the TIMP3 gene is associated with allelic loss on 22q12.3 and malignancy in meningiomas
    Dimitri Barski
    Department of Neuropathology, Heinrich Heine University, Dusseldorf, Germany
    Brain Pathol 20:623-31. 2010
    ....
  94. ncbi Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation
    David S Smookler
    Ontario Cancer Institute, University Health Network, Toronto, Canada
    J Immunol 176:721-5. 2006
    ..Ablation of the TNF receptor gene p55 (Tnfrsf1a) or treatment with a synthetic metalloproteinase inhibitor rescues timp3-/- mice. Thus, TIMP3 is essential for normal innate immune function...
  95. doi Association of an extracellular matrix gene cluster with breast cancer prognosis and endocrine therapy response
    Jozien Helleman
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Clin Cancer Res 14:5555-64. 2008
    ....
  96. ncbi Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3
    S J George
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Circulation 101:296-304. 2000
    ..Here, we overexpressed TIMP-3 at the luminal surface of human saphenous veins before organ culture and in pig saphenous veins before interposition grafting into carotid arteries in vivo to assess neointima formation...
  97. ncbi Regulation of tissue inhibitor of metalloproteinase-3 (Timp-3) mRNA expression during rat CNS development
    D M Jaworski
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Neurosci Res 61:396-408. 2000
    ..These data suggest that TIMP-3 and brevican may act in concert to guide neuronal migration along the RMS...
  98. ncbi Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus. Metalloproteinase inhibition is associated with proapoptotic activity
    M Bond
    Bristol Heart Institute, Level 7, Bristol Royal Infirmary, University of Bristol, Bristol BS2 8HW, United Kingdom
    J Biol Chem 275:41358-63. 2000
    ....
  99. ncbi Fibrogenic and inflammatory cytokines modulate mRNA expressions of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-3 in type II pneumocytes
    Y Hoshino
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Respiration 68:509-16. 2001
    ..Imbalance between proteinases and their inhibitors released from alveolar type II pneumocytes may cause development of inflammatory lung diseases...
  100. ncbi Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis
    Erica L Martin
    Department of Physiology, Lawson Health Research Institute, H417, 268 Grosvenor St, The University of Western Ontario, London, ON, Canada, N6A 4V2
    Am J Physiol Lung Cell Mol Physiol 285:L1222-32. 2003
    ..In conclusion, exposing TIMP-3 null animals to sepsis rapidly enhances the phenotypic abnormalities of these mice, due to increased MMP activity induced by CLP...
  101. ncbi [Stent-based local delivery of therapeutic adenovirus effectively reduces neointimal proliferation in porcine coronaries]
    Yin Xiong Wu
    Guangxi Municipal Hospital, Nanning 530021, China
    Di Yi Jun Yi Da Xue Xue Bao 23:1263-5. 2003
    ..To find an effective means for delivering therapeutic genes of Tissue inhibitor of metalloproteinase-3 (TIMP-3) to the target sites of the dilated coronary artery for the purpose of preventing restenosis of the injured artery...

Research Grants30

  1. Inducible Macrophage Specific Gene Expression in Diseases
    JEANINE M D apos ARMIENTO; Fiscal Year: 2010
    ..We will also examine the consequences of the absence of macrophage tissue inhibitor of metalloproteinases-3 in lung injury. ..
  2. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..Specific aim 3: To develop and test gene vectors expressing inhibitors of angiogenesis (angiostatin, endostatin, PEDF) and test their ability to inhibit subretinal neovascularization in the mutant transgenic mouse. ..
  3. Role of IGF-II in Human Trophoblast-Decidua Interactions
    Linda Giudice; Fiscal Year: 2006
    ..The investigators work with the human model because of the uniqueness of implantation in humans...
  4. REGULATION OF RETINAL NEOVASCULARIZATION BY TIMP3
    Bela Anand Apte; Fiscal Year: 2002
    ..Mutations in the TIMP-3 gene cause Sorsby s fundus dystrophy (SFD), an inherited from of blindness...
  5. Stuart J Frank; Fiscal Year: 2016
    ....
  6. Regulation of Skeletal Muscle Regeneration
    Yi Ping Li; Fiscal Year: 2012
    ..The goal of the current grant application is to identify means for promoting muscle regeneration via the understanding of the signaling mechanisms that regulate myogenesis by activating p38 MAPK in adult muscle. ..
  7. Epigenetic changes predict disease course of HPV-related lesions in women 16-24
    NANCY B contact KIVIAT; Fiscal Year: 2010
    ..abstract_text> ..
  8. The Incidence and Progression of Peripheral Venous Disease
    Michael H Criqui; Fiscal Year: 2010
    ..TCS), and functional disease (reflux or obstruction) by Duplex ultrasound -normal, superficial functional disease (SFD), deep functional disease (DFD)...
  9. Role of TIMP-3 in Ocular Neovascularization
    Bela Anand Apte; Fiscal Year: 2009
    ..Sorsby's Fundus Dystrophy (SFD), a rare, dominantly inherited, early onset macular degenerative disease is of considerable interest as it is the ..
  10. Methylation in Cancer Progression of Barrett's Esophagus
    Jean S Wang; Fiscal Year: 2010
    ..S. has increased more than 300% in the past 40 years and BE is considered to be the primary risk factor for esophageal adenocarcinoma. ..
  11. STUART JAMES SHANKLAND; Fiscal Year: 2016
    ..Determine the role of pericyte-derived TIMP3 and ADAMTS1 in regulation of microvascular stability and VEGF receptor signaling Aim 3. Define pericyte-derived VEGFA as a determinant of spontaneous &induced kidney disease progression. ..
  12. Molecular insights into the pathogenesis of Sorsby Fundus Dystrophy
    Jian Hua Qi; Fiscal Year: 2013
    ..Sorsby fundus dystrophy (SFD), a rare, dominantly inherited, early onset macular degenerative disease that is caused by mutations in the TIMP3 ..
  13. Age-related epigenetic gene silencing in the RPE
    LEONARD HJELMELAND; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. EDRN: Clinical Epidemiology & Validation Centers
    Henry T Lynch; Fiscal Year: 2010
    ..b. a study to evaluate the acceptability of hypothetical biomarkers among high risk and average risk individuals and primary health care providers. ..
  15. Mariano Sebastian Viapiano; Fiscal Year: 2014
    ..These results may translate into novel strategies to disrupt tumor invasion and achieve more effective therapies. ..
  16. Multi-Frequency Synthesis and Orientation Control in SFDI
    Bruce J Tromberg; Fiscal Year: 2013
    ..can potentially decrease the minimum acquisition time to the frame rate of the camera, allowing real-time SFDI and SFD tomography...
  17. Margaret A Pericak-Vance; Fiscal Year: 2014
    ..abstract_text> ..
  18. TGF-Beta signaling and microRNA processing: Implications for invasion and metasta
    ANA CLARA PEREIRA AZEVEDO-POULY; Fiscal Year: 2012
    ..Data acquired from this study my lead to the development of new therapeutic targets to treat metastatic disease. ..
  19. Animal Model for a Hereditary Macular Degeneration
    Jean Bennett; Fiscal Year: 2004
    ..of Metalloproteinases-3-encoding gene (TIMP-3) were identified in patients with Sorsby's fundus dystrophy (SFD) (1-3), a disease with similarities to neovascular AMD (4)...
  20. ANALYSIS OF HUMAN VMD2: A MODEL FOR RPE GENE REGULATION
    Donald Zack; Fiscal Year: 2004
    ..have been shown to cause Leber's Congenital Amaurosis (LCA), retinitis pigmentosa (RP), Sorsby's fundus dystrophy (SFD), and vitelliform macular dystrophy (Best's disease), respectively...
  21. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010
    ....
  22. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..
  23. PATHOGENESIS OF RETINAL DEGENERATIONS
    Samuel Jacobson; Fiscal Year: 2001
    ..studies leading to this proposal was the recent discovery that the autosomal dominant retinal degeneration, SFD, was caused by mutations in the gene encoding an extracellular matrix molecule known as tissue inhibitor of ..
  24. REGULATION OF LUTEAL FUNCTION
    Geula Gibori; Fiscal Year: 2009
    ....
  25. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. FUNCTION OF THE DECIDUAL TISSUE
    Geula Gibori; Fiscal Year: 2007
    ..We will also test the hypothesis that fetal death in 5alphaReductase type 1 null mice is due to the inhibition of IL-11 signaling in the decidua by high levels of estradiol. ..
  27. Perinatal Infection and Memory
    STACI BILBO; Fiscal Year: 2006
    ..The duration of memory impairment will also be measured, and a number of memory paradigms will be tested. ..
  28. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
    ....
  29. Infant hearing for modulated tones
    Barbara Cone Wesson; Fiscal Year: 2003
    ..This research will also result in methods for assessing threshold sensitivity and sound discrimination in infants that can be applied to those at risk for hearing loss or other auditory dysfunction. ..
  30. BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK
    Maria Worsham; Fiscal Year: 2001
    ....