TIMM9

Summary

Gene Symbol: TIMM9
Description: translocase of inner mitochondrial membrane 9
Alias: TIM9, TIM9A, mitochondrial import inner membrane translocase subunit Tim9, translocase of inner mitochondrial membrane 9 homolog
Species: human
Products:     TIMM9

Top Publications

  1. Milenkovic D, Ramming T, Müller J, Wenz L, Gebert N, Schulze Specking A, et al. Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria. Mol Biol Cell. 2009;20:2530-9 pubmed publisher
    ..In this study, we found that a region within the Tim9 and Tim10 precursors, consisting of only nine amino acid residues, functions as a signal for the engagement of ..
  2. Smith J, Singha U, Misra S, Chaudhuri M. Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei. mSphere. 2018;3: pubmed publisher
    ..brucei Tim9 (TbTim9) and Tim10 (TbTim10) and a unique small Tim that shares homology with both Tim8 and Tim13 (TbTim8/13)...
  3. Baker M, Webb C, Stroud D, Palmer C, Frazier A, Guiard B, et al. Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import. Mol Biol Cell. 2009;20:769-79 pubmed publisher
    The Tim9-Tim10 complex plays an essential role in mitochondrial protein import by chaperoning select hydrophobic precursor proteins across the intermembrane space...
  4. Spiller M, Guo L, Wang Q, Tran P, Lu H. Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1. Biosci Rep. 2015;35: pubmed publisher
    ..Tim10 are essential homologue proteins of the mitochondrial intermembrane space (IMS) and form a stable hexameric Tim9-Tim10 complex there...
  5. Rampello A, Glynn S. Identification of a Degradation Signal Sequence within Substrates of the Mitochondrial i-AAA Protease. J Mol Biol. 2017;429:873-885 pubmed publisher
    ..the yeast i-AAA protease, Yme1p, to examine the in vitro degradation of two intermembrane space chaperone subunits, Tim9 and Tim10...
  6. Jin H, Kendall E, Freeman T, Roberts R, Vetrie D. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. Genomics. 1999;61:259-67 pubmed
    ..We also describe the expression patterns and chromosomal locations of their genes, which are candidate loci for autosomal recessive neurodegenerative disorders. ..
  7. Vial S, Lu H, Allen S, Savory P, Thornton D, Sheehan J, et al. Assembly of Tim9 and Tim10 into a functional chaperone. J Biol Chem. 2002;277:36100-8 pubmed
    ..We have characterized TIM10 assembly and analyzed the structural properties of its subunits, Tim9 and Tim10...
  8. Rothbauer U, Hofmann S, Mühlenbein N, Paschen S, Gerbitz K, Neupert W, et al. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. J Biol Chem. 2001;276:37327-34 pubmed
    ..Thus, the pathomechanism underlying the Mohr-Tranebjaerg syndrome may involve an impaired biogenesis of the human TIM23 complex causing severe pleiotropic mitochondrial dysfunction. ..
  9. Mühlenbein N, Hofmann S, Rothbauer U, Bauer M. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. J Biol Chem. 2004;279:13540-6 pubmed
    b>Tim9, Tim10a, and Tim10b are members of the family of small Tim proteins located in the intermembrane space of mammalian mitochondria...

More Information

Publications13

  1. Webb C, Gorman M, Lazarou M, Ryan M, Gulbis J. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. Mol Cell. 2006;21:123-33 pubmed
    ..b>Tim9 and Tim10 are translocase components of the intermembrane space, related to deafness-dystonia peptide 1 (DDP1)...
  2. Sotgia F, Whitaker Menezes D, Martinez Outschoorn U, Salem A, Tsirigos A, Lamb R, et al. Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. Cell Cycle. 2012;11:4390-401 pubmed publisher
    ..translation (AKAP1, GOLPH3, GOLPH3L, MCT1, MRPL40, MRPS7, MRPS15, MRPS22, NRF1, NRF2, PGC1-?, POLRMT, TFAM, TIMM9 and TOMM70A) selectively labeled epithelial breast cancer cells...
  3. Lin C, Fang C, Sun D, Hseu Y, Uen Y, Lin K, et al. High expression of mitochondrial intermembrane chaperone TIMM9 represents a negative prognostic marker in gastric cancer. J Formos Med Assoc. 2017;116:476-483 pubmed publisher
    ..investigated correlations between the expression of a mitochondrial inner membrane protein translocase of inner mitochondrial membrane 9 homolog (TIMM9) and various clinicopathologic parameters as well as patients' survival...
  4. Bauer M, Rothbauer U, Mühlenbein N, Smith R, Gerbitz K, Neupert W, et al. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. FEBS Lett. 1999;464:41-7 pubmed
    ..DDP1 shows similarity to the yeast proteins Tim9, Tim10 and Tim12, components of the mitochondrial import machinery for carrier proteins...