TIMM23

Summary

Gene Symbol: TIMM23
Description: translocase of inner mitochondrial membrane 23
Alias: TIM23, mitochondrial import inner membrane translocase subunit Tim23, translocase of inner mitochondrial membrane 23 homolog, translocase of the inner mitochondrial membrane
Species: human
Products:     TIMM23

Top Publications

  1. Bauer M, Gempel K, Reichert A, Rappold G, Lichtner P, Gerbitz K, et al. Genetic and structural characterization of the human mitochondrial inner membrane translocase. J Mol Biol. 1999;289:69-82 pubmed
    ..In the yeast Saccharomyces cerevisiae, translocation of preproteins into the matrix requires the membrane proteins Tim23, Tim17 and Tim44, which drive translocation in cooperation with mtHsp70 and its co-chaperone Mge1p...
  2. Mick D, Dennerlein S, Wiese H, Reinhold R, Pacheu Grau D, Lorenzi I, et al. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell. 2012;151:1528-41 pubmed publisher
    ..We establish an unexpected molecular link between the TIM23 transport machinery and assembly of respiratory-chain complexes that regulate mitochondrial protein synthesis in ..
  3. Prashar Y, Weissman S. Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs. Proc Natl Acad Sci U S A. 1996;93:659-63 pubmed
    ..These and other results suggest that this approach is suitable for the systematic, expeditious, and nearly exhaustive elucidation of subtle changes in the patterns of gene expression in cells with altered physiologic states. ..
  4. Moro F, Sirrenberg C, Schneider H, Neupert W, Brunner M. The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. EMBO J. 1999;18:3667-75 pubmed
    ..The components Tim17, Tim23 and Tim44 are present in this complex in equimolar amounts...
  5. Yamamoto H, Esaki M, Kanamori T, Tamura Y, Nishikawa S, Endo T. Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. Cell. 2002;111:519-28 pubmed
    ..site-specific photocrosslinking of translocation intermediates, we have identified Tim50, a component of the yeast TIM23 import machinery, which mediates translocation of presequence-containing proteins across the mitochondrial inner ..
  6. Mühlenbein N, Hofmann S, Rothbauer U, Bauer M. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. J Biol Chem. 2004;279:13540-6 pubmed
    ..We conclude that different mechanisms and specific requirements for import and insertion of mammalian carrier preproteins have evolved in higher eukaryotes. ..
  7. Guo Y, Cheong N, Zhang Z, De Rose R, Deng Y, Farber S, et al. Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. J Biol Chem. 2004;279:24813-25 pubmed
    In yeast, Tim50 along with Tim23 regulate translocation of presequence-containing proteins across the mitochondrial inner membrane...
  8. Sinha D, Joshi N, Chittoor B, Samji P, D Silva P. Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet. 2010;19:1248-62 pubmed publisher
    ..Magmas forms a stable subcomplex with J-protein Pam18 or DnaJC19 through its C-terminal region and is tethered to TIM23 complex of yeast and humans...
  9. Zhang Y, Xu Y, Zhao Q, Ji Z, Deng H, Li S. The structural characteristics of human preprotein translocase of the inner mitochondrial membrane Tim23: implications for its physiological activities. Protein Expr Purif. 2012;82:255-62 pubmed publisher
    The preprotein translocase of the inner mitochondrial membrane (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane...

More Information

Publications15

  1. Schusdziarra C, Blamowska M, Azem A, Hell K. Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. Hum Mol Genet. 2013;22:1348-57 pubmed publisher
    ..In addition, MCJ and MAGMAS interact with the core components of the TIM23 pre-protein translocase...
  2. Zhang Y, Deng H, Zhao Q, Li S. Interaction of presequence peptides with human translocase of inner membrane of mitochondria Tim23. Biochem Biophys Res Commun. 2013;437:292-9 pubmed publisher
    The preprotein translocase of the inner membrane of mitochondria (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane...
  3. Sinha D, Srivastava S, Krishna L, D Silva P. Unraveling the intricate organization of mammalian mitochondrial presequence translocases: existence of multiple translocases for maintenance of mitochondrial function. Mol Cell Biol. 2014;34:1757-75 pubmed publisher
    ..role in accurately delivering the nucleus-encoded proteins through membrane-bound presequence translocase (Tim23 complex) machinery...
  4. Aiyar R, Bohnert M, Duvezin Caubet S, Voisset C, Gagneur J, Fritsch E, et al. Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders. Nat Commun. 2014;5:5585 pubmed publisher
    ..Here we demonstrate that modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM23 complex, proves therapeutic in both yeast and patient-derived cells exhibiting ATP synthase deficiency...
  5. Guarani V, McNeill E, Paulo J, Huttlin E, Fröhlich F, Gygi S, et al. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. elife. 2015;4: pubmed publisher
    ..Collectively, our work uncovers a previously unrecognized subunit of the MICOS complex, necessary for CJ integrity, cristae morphology, and mitochondrial function and provides a resource for further analysis of MICOS architecture. ..
  6. Feng W, Zhang Y, Deng H, Li S. Interaction of divalent metal ions with human translocase of inner membrane of mitochondria Tim23. Biochem Biophys Res Commun. 2016;475:76-80 pubmed publisher
    The preprotein translocase of the inner membrane of mitochondria (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane...