Genomes and Genes
Gene Symbol: TIMM23
Description: translocase of inner mitochondrial membrane 23
Alias: TIM23, mitochondrial import inner membrane translocase subunit Tim23, translocase of inner mitochondrial membrane 23 homolog, translocase of the inner mitochondrial membrane
- Schusdziarra C, Blamowska M, Azem A, Hell K. Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. Hum Mol Genet. 2013;22:1348-57 pubmed publisher..In addition, MCJ and MAGMAS interact with the core components of the TIM23 pre-protein translocase...
- Zhang Y, Deng H, Zhao Q, Li S. Interaction of presequence peptides with human translocase of inner membrane of mitochondria Tim23. Biochem Biophys Res Commun. 2013;437:292-9 pubmed publisherThe preprotein translocase of the inner membrane of mitochondria (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane...
- Sinha D, Srivastava S, Krishna L, D Silva P. Unraveling the intricate organization of mammalian mitochondrial presequence translocases: existence of multiple translocases for maintenance of mitochondrial function. Mol Cell Biol. 2014;34:1757-75 pubmed publisher..role in accurately delivering the nucleus-encoded proteins through membrane-bound presequence translocase (Tim23 complex) machinery...
- Aiyar R, Bohnert M, Duvezin Caubet S, Voisset C, Gagneur J, Fritsch E, et al. Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders. Nat Commun. 2014;5:5585 pubmed publisher..Here we demonstrate that modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM23 complex, proves therapeutic in both yeast and patient-derived cells exhibiting ATP synthase deficiency...
- Guarani V, McNeill E, Paulo J, Huttlin E, FrÃ¶hlich F, Gygi S, et al. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. elife. 2015;4: pubmed publisher..Collectively, our work uncovers a previously unrecognized subunit of the MICOS complex, necessary for CJ integrity, cristae morphology, and mitochondrial function and provides a resource for further analysis of MICOS architecture. ..
- Feng W, Zhang Y, Deng H, Li S. Interaction of divalent metal ions with human translocase of inner membrane of mitochondria Tim23. Biochem Biophys Res Commun. 2016;475:76-80 pubmed publisherThe preprotein translocase of the inner membrane of mitochondria (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane...