TIMM13

Summary

Gene Symbol: TIMM13
Description: translocase of inner mitochondrial membrane 13
Alias: TIM13, TIM13B, TIMM13A, TIMM13B, ppv1, mitochondrial import inner membrane translocase subunit Tim13, mitochondrial import inner membrane translocase subunit Tim13B, translocase of inner mitochondrial membrane 13 homolog
Species: human
Products:     TIMM13

Top Publications

  1. Rothbauer U, Hofmann S, Mühlenbein N, Paschen S, Gerbitz K, Neupert W, et al. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. J Biol Chem. 2001;276:37327-34 pubmed
    Tim8 and Tim13 of yeast belong to a family of evolutionary conserved zinc finger proteins that are organized in hetero-oligomeric complexes in the mitochondrial intermembrane space...
  2. Paschen S, Rothbauer U, Kaldi K, Bauer M, Neupert W, Brunner M. The role of the TIM8-13 complex in the import of Tim23 into mitochondria. EMBO J. 2000;19:6392-400 pubmed
    Tim8 and Tim13 are non-essential, conserved proteins of the mitochondrial intermembrane space, which are organized in a hetero-oligomeric complex...
  3. Paschen S, Neupert W. Protein import into mitochondria. IUBMB Life. 2001;52:101-12 pubmed
    ..This is the first known disease, which is caused by an impaired mitochondrial protein import machinery leading to progressive neurodegeneration. ..
  4. Pan H, Wong K, Yang T, Hsu G, Chou C, Huang J, et al. The outcome of a quality-controlled mammography screening program: experience from a population-based study in Taiwan. J Chin Med Assoc. 2014;77:531-4 pubmed publisher
    ..The workload of every screening radiologist, the overall recall rate, positive predictive value (PPV1), cancer detection rate (CDR), cancer incidence rate (CIR) from the screening, 1-year interval cancer, sensitivity, ..
  5. Zeng X, Vonk J, van der Plaat D, Faiz A, Pare P, Joubert P, et al. Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms. Environ Int. 2019;122:263-269 pubmed publisher
    ..Three replicated SNPs were cis-eQTLs for FCER1A, CHN1, and TIMM13 in lung tissue...
  6. Afolabi K, Iweriebor B, Obi L, Okoh A. Prevalence of porcine parvoviruses in some South African swine herds with background of porcine circovirus type 2 infection. Acta Trop. 2019;190:37-44 pubmed publisher
    ..6 to 60%. The findings showed that all the screened parvoviruses were present as follows: PPV1 (29.1%), PPV2 (21.8%), PPV3 (5.5%), PPV4 (43.6%), PBo-likeV (21.8%) and PBoV1/2 (44.6%)...
  7. Tienson H, Dabir D, Neal S, Loo R, Hasson S, Boontheung P, et al. Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins. Mol Biol Cell. 2009;20:3481-90 pubmed publisher
    ..Here, we have reconstituted the oxidative folding pathway in vitro with Tim13 as a substrate and determined the midpoint potentials of Mia40 and Tim13...
  8. Quinlan S, Lanes S, Holick C, Mast T. Accuracy of administrative claims data to identify dose specific rotavirus vaccination information: Implications for studies of vaccine safety. Vaccine. 2015;33:2517-20 pubmed publisher
    ..Medical records were obtained for 85 infants, of which 74 (PPV1 87.1%; 95% CI 78.0-93...
  9. Smith J, Singha U, Misra S, Chaudhuri M. Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei. mSphere. 2018;3: pubmed publisher
    ..brucei Tim9 (TbTim9) and Tim10 (TbTim10) and a unique small Tim that shares homology with both Tim8 and Tim13 (TbTim8/13)...

More Information

Publications40

  1. Henderson L, Benefield T, Marsh M, Schroeder B, Durham D, Yankaskas B, et al. The influence of mammographic technologists on radiologists' ability to interpret screening mammograms in community practice. Acad Radiol. 2015;22:278-89 pubmed publisher
    ..Measures of interpretative performance (recall rate, sensitivity, specificity, positive predictive value [PPV1], and cancer detection rate [CDR]) were ascertained prospectively with cancer outcomes collected from the state ..
  2. Winkler N, Freer P, Anzai Y, Hu N, Stein M. Impact of Immediate Interpretation of Screening Tomosynthesis Mammography on Performance Metrics. Acad Radiol. 2019;26:210-214 pubmed publisher
    ..6; P = .825). There was no statistically significant difference in positive predictive values (PPVs) including PPV1 (screening recall), PPV2 (biopsy recommendation), or PPV 3 (biopsy performed) with batch interpretation (10.1%, 42...
  3. McCarthy A, Kontos D, Synnestvedt M, Tan K, Heitjan D, Schnall M, et al. Screening outcomes following implementation of digital breast tomosynthesis in a general-population screening program. J Natl Cancer Inst. 2014;106: pubmed publisher
    ..There was a statistically significant increase in PPV1 (6.2% vs 4.4%, P = .047). In women younger than age 50 years screened with DBT, there were 17 fewer recalls (12...
  4. Ambinder E, Harvey S, Panigrahi B, Li X, Woods R. Synthesized Mammography: The New Standard of Care When Screening for Breast Cancer with Digital Breast Tomosynthesis?. Acad Radiol. 2018;25:973-976 pubmed publisher
    ..Recall rate, biopsy rate, positive predictive value 1 (PPV1), positive predictive value 3 (PPV3), and cancer detection rate (CDR) were compared between the two groups...
  5. Sun J, Huang L, Wei Y, Wang Y, Chen D, Du W, et al. Identification of three PPV1 VP2 protein-specific B cell linear epitopes using monoclonal antibodies against baculovirus-expressed recombinant VP2 protein. Appl Microbiol Biotechnol. 2015;99:9025-36 pubmed publisher
    Porcine parvovirus type 1 (PPV1) is a major causative agent of embryonic and fetal death in swine...
  6. Ching J, Brem R. Breast Lesions Detected via Molecular Breast Imaging: Physiological Parameters Affecting Interpretation. Acad Radiol. 2018;25:1568-1576 pubmed publisher
    ..One hundred ten of 153 patients were diagnosed with malignancy or high-risk pathology (PPV1 = 71.9%), and 130/193 biopsies resulted in malignant or high-risk lesions (PPV3 = 67.4%)...
  7. Giess C, Poole P, Chikarmane S, Sippo D, Birdwell R. Screening Breast MRI in Patients Previously Treated for Breast Cancer: Diagnostic Yield for Cancer and Abnormal Interpretation Rate. Acad Radiol. 2015;22:1331-7 pubmed publisher
    ..4% (65 of 1194) BI-RADS 4 or 5 and 5.3% (63 of 1194) BI-RADS 3 assessments with a 9.4% positive predictive value (PPV1; 12 of 128 examinations) and a 17.9% PPV3 (12 malignancies per 67 biopsies)...
  8. Conant E, Beaber E, Sprague B, Herschorn S, Weaver D, Onega T, et al. Breast cancer screening using tomosynthesis in combination with digital mammography compared to digital mammography alone: a cohort study within the PROSPR consortium. Breast Cancer Res Treat. 2016;156:109-16 pubmed publisher
    ..9 vs. 4.4/1000 screened, adjusted OR = 1.45, 95 % CI = 1.12-1.88), an improvement in PPV1 (6.4 % for DBT vs. 4.1 % for DM, adjusted OR = 2.02, 95 % CI = 1.54-2...
  9. Hwang J, Han B, Ko E, Shin J, Hahn S, Nam M. Screening Ultrasound in Women with Negative Mammography: Outcome Analysis. Yonsei Med J. 2015;56:1352-8 pubmed publisher
    ..6 per 1000). The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively...
  10. Henderson L, Benefield T, Nyante S, Marsh M, Greenwood Hickman M, Schroeder B. Performance of digital screening mammography in a population-based cohort of black and white women. Cancer Causes Control. 2015;26:1495-9 pubmed publisher
    ..We compared recall rate, sensitivity, specificity, and positive predictive value (PPV1) between black and white women, adjusting for potential confounders using random effects logistic regression...
  11. Moreno Ramos M, Ruíz García E. [An audit of breast cancer screening mammograms and the variability of radiological practice]. Rev Calid Asist. 2016;31:146-51 pubmed publisher
    ..The positive predictive value (PPV) in screening studies (PPV1) was 6.52%...
  12. Neal S, Dabir D, Tienson H, Horn D, Glaeser K, Ogozalek Loo R, et al. Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway. J Biol Chem. 2015;290:20804-14 pubmed publisher
    ..In this study, we have addressed the oxidation of Tim13 in vitro and in organello...
  13. Rehling P, Wiedemann N, Pfanner N, Truscott K. The mitochondrial import machinery for preproteins. Crit Rev Biochem Mol Biol. 2001;36:291-336 pubmed
    ..Moreover, we are now approaching a new era in which elaborated techniques have already allowed and will enable us to gather information about the TOM and TIM complexes on an ultrastructural level. ..
  14. Xing X, Zhou H, Tong L, Chen Y, Sun Y, Wang H, et al. First identification of porcine parvovirus 7 in China. Arch Virol. 2018;163:209-213 pubmed publisher
    ..Seven PPV genotypes (PPV1 to PPV7) have been identified to date...
  15. Jin H, Kendall E, Freeman T, Roberts R, Vetrie D. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. Genomics. 1999;61:259-67 pubmed
    ..We also describe the expression patterns and chromosomal locations of their genes, which are candidate loci for autosomal recessive neurodegenerative disorders. ..
  16. Takahashi Y, Tsuruta S, Honda A, Fujiwara Y, Satoh M, Yasutake A. Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney. J Toxicol Sci. 2012;37:663-6 pubmed
    ..Actb and Timm23) and decrease the expression of 1 gene (Spink3) in the liver, increase the expression of 2 genes (RT1-Bb and Mgat5) and decrease the expression of 6 genes (Tnfaip8, Rara, Slc2a4, Wdr12, Pias4 and Timm13) in the kidney.
  17. Jensen R, Dunn C. Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons. Biochim Biophys Acta. 2002;1592:25-34 pubmed
    ..In addition, the core components of both the TIM23 and TIM22 translocons have been shown to form aqueous pores in the mitochondrial IM. In this review, we summarize what is known about import of proteins across the mitochondrial IM. ..
  18. Roesch K, Curran S, Tranebjaerg L, Koehler C. Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex. Hum Mol Genet. 2002;11:477-86 pubmed
    ..We now show that TIMM8a assembles in a 70 kDa complex in the intermembrane space with TIMM13. DDP1/TIMM8a is not detectable in fibroblasts derived from a patient with a missense mutation in the DDP1/TIMM8a ..
  19. Webb C, Gorman M, Lazarou M, Ryan M, Gulbis J. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. Mol Cell. 2006;21:123-33 pubmed
    ..10 as surrogate lipid contacts. The first reported crystal structure of a mitochondrial translocase assembly provides insights into selectivity and regulation of precursor import. ..
  20. Roesch K, Hynds P, Varga R, Tranebjaerg L, Koehler C. The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex. Hum Mol Genet. 2004;13:2101-11 pubmed
    ..TIMM8a partners with TIMM13 in the mitochondrial intermembrane space to form a 70 kDa complex and facilitates the import of the inner membrane ..
  21. Opriessnig T, Gerber P, Matzinger S, Meng X, Halbur P. Markedly different immune responses and virus kinetics in littermates infected with porcine circovirus type 2 or porcine parvovirus type 1. Vet Immunol Immunopathol. 2017;191:51-59 pubmed publisher
    Porcine parvovirus type 1 (PPV1) and porcine circovirus type 2 (PCV2) are small single-stranded DNA viruses with high prevalence in the global pig population...
  22. Mullen L, Panigrahi B, Hollada J, Panigrahi B, Falomo E, Harvey S. Strategies for Decreasing Screening Mammography Recall Rates While Maintaining Performance Metrics. Acad Radiol. 2017;24:1556-1560 pubmed publisher
    ..Recall rates, cancer detection rates, and positive predictive value 1 (PPV1) were compared before and after each intervention...
  23. Neupert W, Brunner M. The protein import motor of mitochondria. Nat Rev Mol Cell Biol. 2002;3:555-65 pubmed
    ..Here, we review the data for and against each model. ..
  24. Wang Z, Fan M, Candas D, Zhang T, Qin L, Eldridge A, et al. Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Dev Cell. 2014;29:217-32 pubmed publisher
  25. Gentle I, Perry A, Alcock F, Likic V, Dolezal P, Ng E, et al. Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space. Mol Biol Evol. 2007;24:1149-60 pubmed
    ..In yeast, there are 5 small TIM proteins: Tim8, Tim9, Tim10, Tim12, and Tim13, with equivalent proteins reported in humans...
  26. Curran S, Leuenberger D, Schmidt E, Koehler C. The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J Cell Biol. 2002;158:1017-27 pubmed
    ..Thus, polytopic inner membrane proteins, which lack an NH2-terminal targeting sequence, pass through the TOM complex as a loop followed by binding of the small Tim proteins to the hydrophobic membrane spanning domains. ..
  27. Freer P, Riegert J, Eisenmenger L, Ose D, Winkler N, Stein M, et al. Clinical implementation of synthesized mammography with digital breast tomosynthesis in a routine clinical practice. Breast Cancer Res Treat. 2017;166:501-509 pubmed publisher
    ..66), invasive and/or in situ CDR, or percentages of minimal and node-negative cancers. PPV1 significantly increased with SM + DBT relative to FFDM (9.1 vs. 6.2%, p = 0.02)...
  28. Neal S, Dabir D, Wijaya J, Boon C, Koehler C. Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space. Mol Biol Cell. 2017;28:2773-2785 pubmed publisher
    ..In reconstitution studies with reduced Tim13, Mia40, and Erv1, the addition of Osm1 and fumarate completes the disulfide exchange pathway that results in Tim13 ..
  29. Narayan A, Visvanathan K, Harvey S. Comparative effectiveness of breast MRI and mammography in screening young women with elevated risk of developing breast cancer: a retrospective cohort study. Breast Cancer Res Treat. 2016;158:583-9 pubmed publisher
    ..Cancer detection rates, short-term follow-up (BIRADS 3), image-guided biopsy (BIRADS 4,5), and PPV1-3 were calculated...
  30. Chacinska A, Pfanner N, Meisinger C. How mitochondria import hydrophilic and hydrophobic proteins. Trends Cell Biol. 2002;12:299-303 pubmed
  31. Bauer M, Rothbauer U, Mühlenbein N, Smith R, Gerbitz K, Neupert W, et al. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. FEBS Lett. 1999;464:41-7 pubmed
    ..We report the identification, chromosomal localization and expressional analysis of six human family members which represent further candidate genes for neurodegenerative diseases. ..