Gene Symbol: TIMM10B
Description: translocase of inner mitochondrial membrane 10B
Alias: FXC1, TIM10B, Tim9b, mitochondrial import inner membrane translocase subunit Tim10 B, fracture callus 1 homolog, fracture callus protein 1, mitochondrial import inner membrane translocase subunit Tim9 B, translocase of inner mitochondrial membrane 10 homolog B
Hadjiargyrou M, Halsey M, Ahrens W, Rightmire E, McLeod K, Rubin C. Cloning of a novel cDNA expressed during the early stages of fracture healing. Biochem Biophys Res Commun. 1998;249:879-84 pubmed
Using differential mRNA display (DD-PCR), a novel cDNA, FxC1 (Fracture Callus 1) was isolated from the early stages of a healing fractured femur...
Jin H, Kendall E, Freeman T, Roberts R, Vetrie D. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. Genomics. 1999;61:259-67 pubmed
..We also describe the expression patterns and chromosomal locations of their genes, which are candidate loci for autosomal recessive neurodegenerative disorders. ..
Mühlenbein N, Hofmann S, Rothbauer U, Bauer M. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. J Biol Chem. 2004;279:13540-6 pubmed
Tim9, Tim10a, and Tim10b are members of the family of small Tim proteins located in the intermembrane space of mammalian mitochondria...
Kang Y, Baker M, Liem M, Louber J, McKenzie M, Atukorala I, et al
. Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability. elife. 2016;5: pubmed publisher
..Identification of Tim29 highlights the significance of analysing mitochondrial import systems across phylogenetic boundaries, which can reveal novel components and mechanisms in higher organisms. ..
Vukotic M, Nolte H, König T, Saita S, Ananjew M, Kruger M, et al
. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Mol Cell. 2017;67:471-483.e7 pubmed publisher
..The dual function of AGK as lipid kinase and constituent of the TIM22 complex reveals that disturbances in both phospholipid metabolism and mitochondrial protein biogenesis contribute to the pathogenesis of Sengers syndrome. ..
Bauer M, Rothbauer U, Mühlenbein N, Smith R, Gerbitz K, Neupert W, et al
. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. FEBS Lett. 1999;464:41-7 pubmed
..We report the identification, chromosomal localization and expressional analysis of six human family members which represent further candidate genes for neurodegenerative diseases. ..
Rothbauer U, Hofmann S, Mühlenbein N, Paschen S, Gerbitz K, Neupert W, et al
. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. J Biol Chem. 2001;276:37327-34 pubmed
..Thus, the pathomechanism underlying the Mohr-Tranebjaerg syndrome may involve an impaired biogenesis of the human TIM23 complex causing severe pleiotropic mitochondrial dysfunction. ..