TIGAR

Summary

Gene Symbol: TIGAR
Description: TP53 induced glycolysis regulatory phosphatase
Alias: C12orf5, FR2BP, fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, fructose-2,6-bisphosphate 2-phosphatase, transactivated by NS3TP2 protein
Species: human
Products:     TIGAR

Top Publications

  1. Lopez Guerra M, Trigueros Motos L, Molina Arcas M, Villamor N, Casado F, Montserrat E, et al. Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells. Haematologica. 2008;93:1843-51 pubmed publisher
    ..Sixteen of the twenty genes (DDB2, GADD45A, TYMS, BAX, TIGAR, FAS, TNFSF7, TNFSF9, CCNG1, CDKN1A, MDM2, SESN1, MAP4K4, PPM1D, OSBPL3 and WIG1) correlated with the ex vivo ..
  2. Bensaad K, Tsuruta A, Selak M, Vidal M, Nakano K, Bartrons R, et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell. 2006;126:107-20 pubmed
    ..We have identified a p53-inducible gene named TIGAR (TP53-induced glycolysis and apoptosis regulator)...
  3. Li H, Jogl G. Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator). J Biol Chem. 2009;284:1748-54 pubmed publisher
    ..b>TIGAR is a novel p53-inducible gene that inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate, ..
  4. Peña Rico M, Calvo Vidal M, Villalonga Planells R, Martínez Soler F, Gimenez Bonafe P, Navarro Sabate A, et al. TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells. Radiother Oncol. 2011;101:132-9 pubmed publisher
    The TP53 induced glycolysis and apoptosis regulator (TIGAR) functions to lower fructose-2,6-bisphosphate (Fru-2,6-P(2)) levels in cells, consequently decreasing glycolysis and leading to the scavenging of reactive oxygen species (ROS), ..
  5. Wanka C, Steinbach J, Rieger J. Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis. J Biol Chem. 2012;287:33436-46 pubmed
    ..Here, we report on the effects of the p53-dependent effector Tp53-induced glycolysis and apoptosis regulator (TIGAR) on hypoxia-induced cell death...
  6. Madan E, Gogna R, Kuppusamy P, Bhatt M, Pati U, Mahdi A. TIGAR induces p53-mediated cell-cycle arrest by regulation of RB-E2F1 complex. Br J Cancer. 2012;107:516-26 pubmed publisher
    p53 induces cell-cycle arrest and apoptosis in cancer cells and negatively regulates glycolysis via TIGAR. Glycolysis is crucial for cancer progression although TIGAR provides protection from reactive oxygen species and apoptosis...
  7. Won K, Lim S, Kim G, Kim Y, Han S, Song J, et al. Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer. Hum Pathol. 2012;43:221-8 pubmed publisher
    ..to glycolysis via the synthesis of cytochrome c oxidase 2 (SCO2), p53-transactivated TP53-induced glycolysis (TIGAR), and apoptosis regulator...
  8. Cheung E, Ludwig R, Vousden K. Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc Natl Acad Sci U S A. 2012;109:20491-6 pubmed publisher
    The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator) functions as a fructose-2,6-bisphosphatase (Fru-2,6-BPase), and through promotion of the pentose phosphate pathway, increases NADPH production to help ..
  9. Bensaad K, Cheung E, Vousden K. Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J. 2009;28:3015-26 pubmed publisher
    The p53-inducible TIGAR protein functions as a fructose-2,6-bisphosphatase, promoting the pentose phosphate pathway and helping to lower intracellular reactive oxygen species (ROS)...

More Information

Publications103 found, 100 shown here

  1. Zhang D, Zhang T, Wang M, Wang X, Qin Y, Wu J, et al. TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury. Free Radic Biol Med. 2019;137:13-23 pubmed publisher
    ..Our previous studies have shown that TP53-induced glycolysis and apoptosis regulator (TIGAR) ameliorates I/R-induced brain injury and reduces anti-cancer drug-induced autophagy activation...
  2. Zhou W, Zhao T, Du J, Ji G, Li X, Ji S, et al. TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation. Cell Death Dis. 2019;10:198 pubmed publisher
    ..TP53 inducible glycolysis and apoptosis regulator (TIGAR) is an endogenous inhibitor of glycolysis and is highly expressed in mature neurons...
  3. Maurer G, Heller S, Wanka C, Rieger J, Steinbach J. Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide. Int J Mol Sci. 2019;20: pubmed publisher
    The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been shown to decrease glycolysis, to activate the pentose phosphate pathway, and to provide protection against oxidative damage...
  4. Zajkowicz A, Gdowicz Kłosok A, Krześniak M, Ścieglińska D, Rusin M. Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin. Cell Signal. 2015;27:1677-87 pubmed publisher
    ..Other p53 target genes (SESN1, SESN2, TIGAR, DRAM1) were also efficiently upregulated; however, a marker of apoptosis (active caspase-3) appeared only in some ..
  5. Shen M, Zhao X, Zhao L, Shi L, An S, Huang G, et al. Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer. Mol Cancer. 2018;17:88 pubmed publisher
    b>TIGAR is a p53 target gene that is known to protect cells from ROS-induced apoptosis by promoting the pentose phosphate pathway. The role of TIGAR in tumor cell invasion and metastasis remains elusive...
  6. Chen Y, Guo Y, Shi K, Huang H, Huang S, Xu W, et al. Down-regulation of microRNA-144-3p and its clinical value in non-small cell lung cancer: a comprehensive analysis based on microarray, miRNA-sequencing, and quantitative real-time PCR data. Respir Res. 2019;20:48 pubmed publisher
    ..Additionally, PPI revealed five genes-C12orf5, CEP55, E2F8, STIL, and TOP2A-as hub genes with the threshold value of 6...
  7. López K, Simpson J, Watson L, Mortiboys H, Hautbergue G, Bandmann O, et al. TIGAR inclusion pathology is specific for Lewy body diseases. Brain Res. 2019;1706:218-223 pubmed publisher
    We previously reported up-regulation of tigarb (the zebrafish orthologue of human TIGAR, TP53 - Induced Glycolysis and Apoptosis Regulator) in a zebrafish pink1-/- model of Parkinson's disease (PD)...
  8. Eleftheriadis T, Pissas G, Antoniadi G, Spanoulis A, Liakopoulos V, Stefanidis I. Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation. Int Immunol. 2014;26:673-84 pubmed publisher
    ..In conclusion, in alloreactive T cells, IDO increases p53 levels, and both IDO and p53 inhibit cell proliferation, glucose consumption and glycolysis. Lactate production and glutaminolysis are also suppressed by IDO, but not by p53. ..
  9. Lin L, Mi Y, Li X, Peng C, Shangguan Z, Li Z, et al. Higher plasma concentration of TP53-induced glycolysis and apoptosis regulator is associated with a lower risk of colorectal cancer metastasis. Cancer Manag Res. 2019;11:263-272 pubmed publisher
    We aimed to explore the association of plasma TP53-induced glycolysis and apoptosis regulator (TIGAR) level with colorectal cancer (CRC) metastasis. A cross-sectional study of 126 CRC patients was conducted in Xiamen, China...
  10. Wong E, Wong S, Chan C, Lam E, Ho L, Lau C, et al. TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells. Oncol Lett. 2015;9:569-574 pubmed
    ..i>TP53-induced glycolysis and apoptosis regulator (TIGAR) is the protein product of the p53 target gene, C12orf5...
  11. Wei M, Peng J, Wu P, Chen P, Yang H, Cui Y, et al. Prognostic value of TIGAR and LC3B protein expression in nasopharyngeal carcinoma. Cancer Manag Res. 2018;10:5605-5616 pubmed publisher
    ..As TP53-induced glycolysis and apoptosis regulator (TIGAR) is among the important genes that can regulate autophagy, we aimed to investigate the correlation between the ..
  12. Ahmad F, Ghosh S, Sinha S, Joshi S, Mehta V, Sen E. TGF-β-induced hCG-β regulates redox homeostasis in glioma cells. Mol Cell Biochem. 2015;399:105-12 pubmed publisher
    ..reductase (TrxR) activity, and (iii) abrogated expression of TP53-induced glycolysis and apoptosis regulator (TIGAR)...
  13. Khan D, Katoch A, Das A, Sharathchandra A, Lal R, Roy P, et al. Reversible induction of translational isoforms of p53 in glucose deprivation. Cell Death Differ. 2015;22:1203-18 pubmed publisher
    ..mRNAs in the p53 and Δ40p53 target genes involved in cell-cycle arrest, metabolism and apoptosis such as p21, TIGAR and Bax...
  14. Hasegawa M, Sinha R, Kumar M, Alam M, Yin L, Raina D, et al. Intracellular Targeting of the Oncogenic MUC1-C Protein with a Novel GO-203 Nanoparticle Formulation. Clin Cancer Res. 2015;21:2338-47 pubmed publisher
    ..GO-203/nanoparticle treatment was also effective in downregulating TIGAR, disrupting redox balance, and inhibiting the self-renewal capacity of cancer cells...
  15. Liu J, Lu F, Gong Y, Zhao C, Pan Q, Ballantyne S, et al. High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma. Hum Pathol. 2018;77:54-62 pubmed publisher
    Synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR) are 2 p53-mediated proteins that can play a regulatory role in cancer energy metabolism...
  16. Kumar B, Iqbal M, Singh R, Bamezai R. Resveratrol inhibits TIGAR to promote ROS induced apoptosis and autophagy. Biochimie. 2015;118:26-35 pubmed publisher
    Resveratrol has been shown to exhibit its anti-cancer effect through a variety of mechanisms. Here, TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator) was identified as an important target of resveratrol for exhibiting ROS-dependent-..
  17. Wang J, Duan Z, Nugent Z, Zou J, Borowsky A, Zhang Y, et al. Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes. Cancer Lett. 2016;378:69-79 pubmed publisher
    ..of glycolysis and the pentose phosphate pathway (PPP), as well as TP53-induced glycolysis regulatory phosphatase TIGAR. Consequently, NSD2-driven tamoxifen-resistant cells and tumors displayed heightened PPP activity, elevated NADPH ..
  18. Ajayi A, Yu X, Wahlo Svedin C, Tsirigotaki G, Karlström V, Ström A. Altered p53 and NOX1 activity cause bioenergetic defects in a SCA7 polyglutamine disease model. Biochim Biophys Acta. 2015;1847:418-428 pubmed publisher
    ..transcriptional activity of p53 was reduced, resulting in a 50% decrease of key p53 target proteins, like AIF and TIGAR. In contrast, the expression of NOX1 was increased approximately 2 times in SCA7 cells...
  19. Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, et al. DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Cell Cycle. 2015;14:375-87 pubmed publisher
    ..of DAXX impacted neither p53 stabilization nor p53-mediated expression of Gadd45a, Noxa, Mdm2, p21, Puma, Sesn2, Tigar or Wip1...
  20. Zhao Y, Zhang L, Wu Y, Dai Q, Zhou Y, Li Z, et al. Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53. Pharmacol Res. 2018;135:49-59 pubmed publisher
    ..Wogonin increases the expression of p53 and p53-inducible glycolysis and apoptosis regulator (TIGAR), while decreases glucose transporter 1 (GLUT1) and some key glycolytic enzymes...
  21. Yin L, Kosugi M, Kufe D. Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH. Blood. 2012;119:810-6 pubmed publisher
    ..in ROS were also associated with down-regulation of the p53-inducible regulator of glycolysis and apoptosis (TIGAR)...
  22. Flinn L, Keatinge M, Bretaud S, Mortiboys H, Matsui H, De Felice E, et al. TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency. Ann Neurol. 2013;74:837-47 pubmed publisher
    ..Expression of TigarB, the zebrafish orthologue of the human, TP53-induced glycolysis and apoptosis regulator TIGAR, was markedly increased in pink(-/-) larvae...
  23. Liu W, Xu X, Fan Z, Sun G, Han Y, Zhang D, et al. Wnt signaling activates TIGAR and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea. Antioxid Redox Signal. 2018;: pubmed publisher
    ..TP53-induced glycolysis and apoptosis regulator (TIGAR), which scavenges intracellular reactive oxygen species (ROS), was upregulated in SGNs in response to cisplatin ..
  24. Sun M, Li M, Huang Q, Han F, Gu J, Xie J, et al. Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism. Neurochem Int. 2015;80:99-109 pubmed publisher
    We previously found that TIGAR (TP53-induced glycolysis and apoptosis regulator) was upregulated in response to ischemia/reperfusion insult in a TP53-independent manner...
  25. Tang Y, Kwon H, Neel B, Kasher Meron M, Pessin J, Yamada E, et al. The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC. J Biol Chem. 2018;293:7578-7591 pubmed publisher
    ..In this study, we discovered that the fructose-2,6-bisphosphatase TIGAR (Tp53-induced glycolysis and apoptosis regulator) critically regulates NF-κB activation...
  26. VOUSDEN K. Finding clues in the p53 maze: an interview with Karen Vousden. Dis Model Mech. 2018;11: pubmed publisher
    ..Her group (in parallel with others) discovered the p53 targets PUMA and TIGAR, the latter of which spurred her interest in cancer metabolism.
  27. Kim J, Devalaraja Narashimha K, Padanilam B. TIGAR regulates glycolysis in ischemic kidney proximal tubules. Am J Physiol Renal Physiol. 2015;308:F298-308 pubmed publisher
    Tp53-induced glycolysis and apoptosis regulator (TIGAR) activation blocks glycolytic ATP synthesis by inhibiting phosphofructokinase-1 activity...
  28. Venkatanarayan A, Raulji P, Norton W, Flores E. Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73. Cell Cycle. 2016;15:164-71 pubmed publisher
    ..of both ΔNp63 and ΔNp73 in combination results in upregulation of 3 key metabolic regulators, IAPP, GLS2, and TIGAR resulting in an increase in apoptosis and tumor regression in ΔNp63/ΔNp73/p53 deficient thymic lymphomas...
  29. Wang H, Cheng Q, Li X, Hu F, Han L, Zhang H, et al. Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice. Mol Cell Proteomics. 2018;17:1354-1364 pubmed publisher
    ..In the present study, by conducting a comparative proteomic analysis, we identified a reduced expression of TIGAR (TP53-induced glycolysis and apoptosis regulator) protein in ovulated oocytes from high-fat diet (HFD)-fed mice...
  30. Feng J, Luo L, Liu Y, Fu S, Chen J, Duan X, et al. TP53-induced glycolysis and apoptosis regulator is indispensable for mitochondria quality control and degradation following damage. Oncol Lett. 2018;15:155-160 pubmed publisher
    ..TP53-induced glycolysis and apoptosis regulator (TIGAR) serves a role in suppressing ROS damage and may protect mitochondria integrity...
  31. Li B, Wang Z, Xie J, Wang G, Qian L, Guan X, et al. TIGAR knockdown enhanced the anticancer effect of aescin via regulating autophagy and apoptosis in colorectal cancer cells. Acta Pharmacol Sin. 2019;40:111-121 pubmed publisher
    Our previous study showed that TP53-induced glycolysis and apoptosis regulator (TIGAR) regulated ROS, autophagy, and apoptosis in response to hypoxia and chemotherapeutic drugs...
  32. Hutchison T, Malu A, Yapindi L, Bergeson R, Peck K, Romeo M, et al. The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30II and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma. Virology. 2018;520:39-58 pubmed publisher
    ..HTLV-1 latency-maintenance factor p30II induces the TP53-induced glycolysis and apoptosis regulator (TIGAR) and counters the oxidative stress, mitochondrial damage, and cytotoxicity caused by the viral oncoproteins Tax ..
  33. Zhang G, Gu D, Zhao Q, Chu H, Xu Z, Wang M, et al. Genetic variation in C12orf51 is associated with prognosis of intestinal-type gastric cancer in a Chinese population. Biomed Pharmacother. 2015;69:133-8 pubmed publisher
    ..No significant association was observed between rs2074356 and the survival of gastric cancer. C12orf5 rs11066280 could be useful marker of survival assessment and individualized clinical therapy for gastric cancer, ..
  34. Ahmad R, Alam M, Hasegawa M, Uchida Y, Al Obaid O, Kharbanda S, et al. Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer. Mol Cancer. 2017;16:33 pubmed publisher
    ..b>TIGAR mRNA level was determined using qRT-PCR...
  35. Miok V, Wilting S, van de Wiel M, Jaspers A, van Noort P, Brakenhoff R, et al. tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities. BMC Bioinformatics. 2014;15:327 pubmed publisher
    ..Finally, the proposed method is able to handle count (RNAseq) data from time course experiments as is shown on a real data set. ..
  36. Shi X, Xiong L, Xiao L, Meng C, Qi G, Li W. Downregulation of caveolin‑1 upregulates the expression of growth factors and regulators in co‑culture of fibroblasts with cancer cells. Mol Med Rep. 2016;13:744-52 pubmed publisher
    ..Tumor protein 53‑induced glycolysis and apoptosis regulator (TIGAR) was upregulated in the BT474 cells under the condition of co‑culture with Cav‑1 siRNA fibroblasts, ..
  37. Hong M, Xia Y, Zhu Y, Zhao H, Zhu H, Xie Y, et al. TP53-induced glycolysis and apoptosis regulator protects from spontaneous apoptosis and predicts poor prognosis in chronic lymphocytic leukemia. Leuk Res. 2016;50:72-77 pubmed publisher
    ..TP53-induced glycolysis and apoptosis regulator (TIGAR) has been directly implicated in cellular metabolism in the control of glycolysis...
  38. Cao L, Chen J, Li M, Qin Y, Sun M, Sheng R, et al. Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury. Neurosci Bull. 2015;31:527-40 pubmed publisher
    In previous studies, we showed that TP53-induced glycolysis and apoptosis regulator (TIGAR) protects neurons against ischemic brain injury...
  39. Nariai N, Kojima K, Mimori T, Kawai Y, Nagasaki M. A Bayesian approach for estimating allele-specific expression from RNA-Seq data with diploid genomes. BMC Genomics. 2016;17 Suppl 1:2 pubmed publisher
    ..The proposed method, called ASE-TIGAR, enables accurate estimation of gene expression from RNA-Seq data in an allele-specific manner...
  40. Wu G, Liu X, Lu N, Liu Q, Tian Y, Ye W, et al. Endothelial ErbB4 deficit induces alterations in exploratory behavior and brain energy metabolism in mice. CNS Neurosci Ther. 2017;23:510-517 pubmed publisher
    ..Consistently, the immunoblot data demonstrate the downregulation of brain Glut1, phospho-ULK1 (Ser555), and TIGAR in the endothelial ErbB4 conditional knockout mice...
  41. Al Maghrebi M, Renno W. Altered expression profile of glycolytic enzymes during testicular ischemia reperfusion injury is associated with the p53/TIGAR pathway: effect of fructose 1,6-diphosphate. Peerj. 2016;4:e2195 pubmed publisher
    ..were used to evaluate the expression of p53 and TP53-induced glycolysis and apoptosis regulator (TIGAR). Results...
  42. Chen J, Zhang D, Feng X, Wang J, Qin Y, Zhang T, et al. TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes. Neuropharmacology. 2018;131:377-388 pubmed publisher
    ..We previously demonstrated a protective role of TP53-induced glycolysis and apoptosis regulator (TIGAR) in ischemic neuronal injury through increasing the flow of pentose phosphate pathway (PPP)...
  43. Wang S, Peng Z, Wang S, Yang L, Chen Y, Kong X, et al. KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration. Cell Res. 2018;28:572-592 pubmed publisher
    ..Here, we identified two KRAB-type zinc-finger proteins, PITA (p53 inhibitor of TIGAR activation) and PISA (p53 inhibitor of SCO2 activation), as selective regulators of p53 in metabolic control...
  44. Capurso G, Archibugi L, Pasquali P, Aceti A, Balducci P, Bianchi P, et al. Prevalence of chronic pancreatitis: Results of a primary care physician-based population study. Dig Liver Dis. 2017;49:535-539 pubmed publisher
    ..reviewed and chronic pancreatitis cases defined according to M-ANNHEIM criteria for diagnosis and severity and TIGAR-O classification for etiology. Twenty-three primary care physicians participated in the study...
  45. Fernandez M, Arvanitakis M, Musala C, Deviere J, Van Steenbergen W, Putzeys V, et al. The Belgian national registry on chronic pancreatitis: A prospective multi-centre study covering more than 800 patients in one year. Pancreatology. 2017;17:572-579 pubmed publisher
    ..The main etiological risk factors according to the TIGAR-O classification were alcohol and tobacco (67%). Current drinkers had lower body mass index (BMI) (21...
  46. Ghildiyal R, Sen E. CK2 induced RIG-I drives metabolic adaptations in IFNγ-treated glioma cells. Cytokine. 2017;89:219-228 pubmed publisher
    ..no effect on glioma cell survival, it increased expression of p53 and its downstream target TP53 induced glycolysis and apoptosis regulator (TIGAR)...
  47. Zhou J, Zhang T, Song D, Xia Y, Qin Z, Sheng R. TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis. Sci Rep. 2016;6:27096 pubmed publisher
    Previous study showed that TIGAR (TP53-induced glycolysis and apoptosis regulator) protected ischemic brain injury via enhancing pentose phosphate pathway (PPP) flux and preserving mitochondria function...
  48. Rajeshkumar N, Dutta P, Yabuuchi S, de Wilde R, Martinez G, Le A, et al. Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function. Cancer Res. 2015;75:3355-64 pubmed publisher
    ..conversion only in mutant TP53 tumors, a feature associated with reduced expression of the TP53 target gene TIGAR, which is known to regulate glycolysis...
  49. Lee P, Hock A, Vousden K, Cheung E. p53- and p73-independent activation of TIGAR expression in vivo. Cell Death Dis. 2015;6:e1842 pubmed publisher
    b>TIGAR (TP53-induced glycolysis and apoptosis regulator) functions as a fructose-2,6-bisphosphatase and its expression results in a dampening of the glycolytic pathway, while increasing antioxidant capacity by increasing NADPH and GSH ..
  50. Romeo M, Hutchison T, Malu A, White A, Kim J, Gardner R, et al. The human T-cell leukemia virus type-1 p30II protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis. Virology. 2018;518:103-115 pubmed publisher
    ..Here we show that the Tp53-induced glycolysis and apoptosis regulator (TIGAR) promotes c-myc oncogene-activation by the human T-cell leukemia virus type-1 (HTLV-1) latency-maintenance factor ..
  51. Cheung E, Lee P, Ceteci F, Nixon C, Blyth K, Sansom O, et al. Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes Dev. 2016;30:52-63 pubmed publisher
    ..However, APC loss also increased the expression of TIGAR, which functions to limit ROS...
  52. Hamada H, Okae H, Toh H, Chiba H, Hiura H, Shirane K, et al. Allele-Specific Methylome and Transcriptome Analysis Reveals Widespread Imprinting in the Human Placenta. Am J Hum Genet. 2016;99:1045-1058 pubmed publisher
    ..g., TIGAR, SLC4A7, PROSER2-AS1, and KLHDC10), and three imprinted gene clusters were identified...
  53. Li M, Zhou Z, Sun M, Cao L, Chen J, Qin Y, et al. Reduced Nicotinamide Adenine Dinucleotide Phosphate, a Pentose Phosphate Pathway Product, Might Be a Novel Drug Candidate for Ischemic Stroke. Stroke. 2016;47:187-95 pubmed publisher
    ..Administration of exogenous NADPH significantly protected neurons against ischemia/reperfusion-induced injury in 2 rodent stroke models. Thus, NADPH might be a promising drug candidate for treatment of ischemic stroke. ..
  54. Ye L, Zhao X, Lu J, Qian G, Zheng J, Ge S. Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2013;437:300-6 pubmed publisher
    ..b>TIGAR (TP53-induced glycolysis and apoptosis regulator), which is a p53-inducible gene, functions in the suppression of ..
  55. Zhou X, Xie W, Li Q, Zhang Y, Zhang J, Zhao X, et al. TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer. PLoS ONE. 2013;8:e80576 pubmed publisher
    ..Tp53-induced glycolysis and apoptosis regulator (TIGAR) is an important P53-induced protein that can inhibit glycolysis; however, there have been few clinical studies on ..
  56. Ahmad F, Dixit D, Joshi S, Sen E. G9a inhibition induced PKM2 regulates autophagic responses. Int J Biochem Cell Biol. 2016;78:87-95 pubmed publisher
    ..Interestingly, BIX induced increase in metabolic modelers TIGAR (TP53-induced glycolysis and apoptosis regulator) and PKM2 (Pyruvate kinase M2) were crucial for BIX-mediated ..
  57. Kim S, Choi S, Won K, Lim S. Distinctive interrelation of p53 with SCO2, COX, and TIGAR in human gastric cancer. Pathol Res Pract. 2016;212:904-910 pubmed publisher
    ..c oxidase 2 (SCO2), cytochrome c oxidase complex (COX), and TP53-induced glycolysis and apoptosis regulator (TIGAR)...
  58. Yin L, Kufe T, Avigan D, Kufe D. Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death. Blood. 2014;123:2997-3006 pubmed publisher
    ..GO-203 and BTZ synergistically downregulate expression of the p53-inducible regulator of glycolysis and apoptosis (TIGAR), which promotes shunting of glucose-6-phosphate into the pentose phosphate pathway to generate reduced ..
  59. Tai G, Zhang H, Du J, Chen G, Huang J, Yu J, et al. TIGAR overexpression diminishes radiosensitivity of parotid gland fibroblast cells and inhibits IR-induced cell autophagy. Int J Clin Exp Pathol. 2015;8:4823-9 pubmed
    Our previous study proved that TP53-induced glycolysis and apoptosis regulator (TIGAR) abrogation is able to radiosensitize glioma cells...
  60. Al Khayal K, Abdulla M, Al Obeed O, Al Kattan W, Zubaidi A, Vaali Mohammed M, et al. Identification of the TP53-induced glycolysis and apoptosis regulator in various stages of colorectal cancer patients. Oncol Rep. 2016;35:1281-6 pubmed publisher
    The TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target gene known to regulate glycolysis by acting as fructose bis-phosphatase (FBPase) and modulate reactive oxygen species...
  61. Simon Molas H, Calvo Vidal M, Castaño E, Rodríguez García A, Navarro Sabate A, Bartrons R, et al. Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition. FEBS Lett. 2016;590:2915-26 pubmed publisher
    ..In this work, we investigate the crosstalk between PFKFB3 and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress...
  62. Green D, Chipuk J. p53 and metabolism: Inside the TIGAR. Cell. 2006;126:30-2 pubmed
    ..The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy. ..
  63. Ko Y, Domingo Vidal M, Roche M, Lin Z, Whitaker Menezes D, Seifert E, et al. TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. J Biol Chem. 2016;291:26291-26303 pubmed
    ..TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces glycolysis and is highly expressed in carcinoma cells in the majority of human ..
  64. Cheung E, Athineos D, Lee P, Ridgway R, Lambie W, Nixon C, et al. TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev Cell. 2013;25:463-77 pubmed publisher
    Regulation of metabolic pathways plays an important role in controlling cell growth, proliferation, and survival. TIGAR acts as a fructose-2,6-bisphosphatase, potentially promoting the pentose phosphate pathway to produce NADPH for ..
  65. Jia W, Zhang B, Matsuo K, Shin A, Xiang Y, Jee S, et al. Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Nat Genet. 2013;45:191-6 pubmed publisher
    ..This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC. ..
  66. Zou S, Wang X, Deng L, Wang Y, Huang B, Zhang N, et al. CREB, another culprit for TIGAR promoter activity and expression. Biochem Biophys Res Commun. 2013;439:481-6 pubmed publisher
    Cellular expression of the TP53-induced glycolysis and apoptosis regulator (TIGAR) protein results in the down-regulation of glycolysis, reduction of intracellular levels of reactive oxygen species, and protection from apoptosis...
  67. Huang S, Yang Z, Ma Y, Yang Y, Wang S. miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells. DNA Cell Biol. 2017;36:303-310 pubmed publisher
    Tp53-induced glycolysis and apoptosis regulator (TIGAR) enhances the pentose phosphate pathway, thereby contributing directly to DNA repair due to generation of nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate, ..
  68. Xu X, Liu C, Bao J. Hypoxia-induced hsa-miR-101 promotes glycolysis by targeting TIGAR mRNA in clear cell renal cell carcinoma. Mol Med Rep. 2017;15:1373-1378 pubmed publisher
    ..As a predicted target, the mRNA and protein levels of TP53?induced glycolysis and apoptosis regulator (TIGAR) were then assessed...
  69. Zou S, Gu Z, Ni P, Liu X, Wang J, Fan Q. SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines. Mol Cell Biochem. 2012;359:17-23 pubmed publisher
    b>TIGAR expression resulted in down-regulation of glycolysis, reduction of intracellular levels of reactive oxygen species, and protection from apoptosis. Despite biological importance, its promoter has not yet been characterized...
  70. Yu H, Xie J, Li B, Sun Y, Gao Q, Ding Z, et al. TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway. Sci Rep. 2015;5:9853 pubmed publisher
    Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux...
  71. Iwao C, Shidoji Y. Upregulation of energy metabolism-related, p53-target TIGAR and SCO2 in HuH-7 cells with p53 mutation by geranylgeranoic acid treatment. Biomed Res. 2015;36:371-81 pubmed publisher
    ..GGA), induces upregulation of the cellular protein levels of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2) in human hepatoma-derived HuH-7cells harboring the mutant TP53 ..
  72. Wang S, Li D, Ou Y, Jiang L, Chen Y, Zhao Y, et al. Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression. Cell Rep. 2016;17:366-373 pubmed publisher
    ..K98R+ 3KR[K117R+K161R+K162R]) completely abolish its ability to regulate metabolic targets, such as TIGAR and SLC7A11...
  73. Qian S, Li J, Hong M, Zhu Y, Zhao H, Xie Y, et al. TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia. J Hematol Oncol. 2016;9:128 pubmed
    ..The TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits aerobic glycolysis and protects tumor cells from intracellular reactive oxygen species (ROS)-associated ..
  74. Jiang L, Cao L, Ma Y, Chen Q, Liang Y, Yuan F, et al. TIGAR mediates the inhibitory role of hypoxia on ROS production and apoptosis in rat nucleus pulposus cells. Osteoarthritis Cartilage. 2018;26:138-148 pubmed publisher
    ..The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been reported to suppress oxidative stress...
  75. Lui V, Wong E, Ho K, Ng P, Lau C, Tsui S, et al. Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death. Oncogene. 2011;30:1127-34 pubmed publisher
    ..inhibition of c-Met resulted in significant downregulation of TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) and subsequent depletion of intracellular NADPH...
  76. Dai Q, Yin Y, Liu W, Wei L, Zhou Y, Li Z, et al. Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells. Int J Biochem Cell Biol. 2013;45:1468-78 pubmed publisher
    ..oroxylin A could increase protein and mRNA expression of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2), which are the key metabolic modulators regulated by p53...
  77. Chen S, Li P, Li J, Wang Y, Du Y, Chen X, et al. MiR-144 inhibits proliferation and induces apoptosis and autophagy in lung cancer cells by targeting TIGAR. Cell Physiol Biochem. 2015;35:997-1007 pubmed publisher
    ..The p53-induced glycolysis and apoptosis regulator (TIGAR) was discovered through microarray analysis of gene expression following activation of p53...
  78. Jain S, Washington A, Leaf R, Bhargava P, Clark R, Kupper T, et al. Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma. Mol Cancer Ther. 2017;16:2304-2314 pubmed publisher
    ..of reactive oxygen species (ROS) levels and decreased levels of scavenger molecules, NADP, NADPH, glutathione, and TIGAR, critical to intracellular redox homeostasis...
  79. Loehrer P, Birch R, Williams S, Greco F, Einhorn L. Chemotherapy of metastatic seminoma: the Southeastern Cancer Study Group experience. J Clin Oncol. 1987;5:1212-20 pubmed
    ..This study confirms the chemosensitivity of metastatic seminoma in a cooperative group setting and defines prognostic factors useful for comparison of other chemotherapeutic trials in seminoma. ..
  80. Jen K, Cheung V. Identification of novel p53 target genes in ionizing radiation response. Cancer Res. 2005;65:7666-73 pubmed
    ..Identification and characterization of ionizing radiation-responsive p53 target genes extend our knowledge of the diverse role that p53 plays in the DNA damage response. ..
  81. Treviño L, Yang W, French D, Hunger S, Carroll W, Devidas M, et al. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet. 2009;41:1001-5 pubmed publisher
    ..86, respectively) and were associated with methotrexate accumulation and gene expression pattern in leukemic lymphoblasts. We conclude that germline variants affect susceptibility to, and characteristics of, specific ALL subtypes. ..
  82. Kim S, Jung H, Lim C. Reactive oxygen species-dependent down-regulation of tumor suppressor genes PTEN, USP28, DRAM, TIGAR, and CYLD under oxidative stress. Biochem Genet. 2013;51:901-15 pubmed publisher
    ..28 (USP28), damage-regulated autophagy modulator (DRAM), TP53-induced glycolysis and apoptosis regulator (TIGAR), and cylindromatosis (CYLD)...
  83. Zhao M, Fan J, Liu Y, Yu Y, Xu J, Wen Q, et al. Oncogenic role of the TP53-induced glycolysis and apoptosis regulator in nasopharyngeal carcinoma through NF-κB pathway modulation. Int J Oncol. 2016;48:756-64 pubmed publisher
    The TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target gene, which functions to suppress reactive oxygen species (ROS) damage and protect cells from apoptosis...
  84. Schneider L, Ulrich M, Lehr T, Menche D, Muller R, von Schwarzenberg K. MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition. Mol Oncol. 2016;10:1054-62 pubmed publisher
    ..Mechanistically, this effect could presumably be attributed to reduction of glycolysis as TIGAR mRNA levels were increased and glucose uptake and Glut1 protein levels were reduced...
  85. Singh A, Sen E. Reciprocal role of SIRT6 and Hexokinase 2 in the regulation of autophagy driven monocyte differentiation. Exp Cell Res. 2017;360:365-374 pubmed publisher
    ..While inhibition of HK2 either by Lonidamine or siRNA further elevated PMA induced Chibby, mitochondrial ROS, TIGAR and LC3II levels; siRNA mediated knock-down of SIRT6 exhibited contradictory effects as compared to HK2...
  86. Sinha S, Ghildiyal R, Mehta V, Sen E. ATM-NF?B axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNF?. Cell Death Dis. 2013;4:e615 pubmed publisher
    ..NCS-induced p53 expression was accompanied by increase in TP53-induced glycolysis and apoptosis regulator (TIGAR) levels and ATM phosphorylation. siRNA-mediated knockdown of TIGAR abrogated NCS-induced apoptosis...
  87. Gerin I, Noel G, Bolsée J, Haumont O, van Schaftingen E, Bommer G. Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase. Biochem J. 2014;458:439-48 pubmed publisher
    The p53-induced protein TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] is considered to be a F26BPase (fructose-2,6-bisphosphatase) with an important role in cancer cell metabolism...
  88. Wilde L, Roche M, Domingo Vidal M, Tanson K, Philp N, Curry J, et al. Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development. Semin Oncol. 2017;44:198-203 pubmed publisher
    ..MYC and TIGAR, which are genes involved in cellular proliferation and anabolism, are inducers of MCT1...
  89. Xie J, Li B, Yu H, Gao Q, Li W, Wu H, et al. TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy. Cancer Res. 2014;74:5127-38 pubmed publisher
    The p53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis, resulting in higher intracellular NADPH, lower reactive oxygen species (ROS) and autophagy activity...
  90. Ma T, Zhang Y, Zhang C, Luo J, Kong L. Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells. Biochem Pharmacol. 2017;143:90-106 pubmed publisher
    ..In this study, we investigated the role of TIGAR and ROS in PB-induced apoptosis and autophagosome formation in human breast carcinoma MDA-MB-231 and MCF-7 cells...
  91. . Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000;26:345-8 pubmed
    ..We identified missense mutations in a gene encoding a new member of the fibroblast growth factor (FGF) family, FGF23. These mutations in patients with ADHR represent the first mutations found in a human FGF gene. ..
  92. Cao L, Zhang D, Chen J, Qin Y, Sheng R, Feng X, et al. G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway. Free Radic Biol Med. 2017;112:433-444 pubmed publisher
    b>TIGAR-regulated pentose phosphate pathway (PPP) plays a critical role in the neuronal survival during cerebral ischemia/reperfusion...