Gene Symbol: TICAM1
Description: toll like receptor adaptor molecule 1
Alias: IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, TIR domain-containing adapter molecule 1, TIR domain containing adaptor inducing interferon-beta, TIR domain-containing adapter protein inducing IFN-beta, proline-rich, vinculin and TIR domain-containing protein B, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Species: human
Products:     TICAM1

Top Publications

  1. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003;301:640-3 pubmed
    ..Here we disrupted the gene encoding a Toll/IL-1 receptor (TIR) domain-containing adaptor, TRIF. TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-beta and activation of IRF-3...
  2. Bin L, Xu L, Shu H. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem. 2003;278:24526-32 pubmed
    ..Our findings suggest that TIRP is involved in IL-1-triggered NF-kappaB activation and functions upstream of IRAK, IRAK-2, TRAF6, and IKKbeta ..
  3. Fearns C, Pan Q, Mathison J, Chuang T. Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. J Biol Chem. 2006;281:34592-600 pubmed
    ..Triad3A promoted down-regulation of two TIR domain-containing adapter proteins, TIRAP and TRIF, as well as a RIP1 but had no effect on other adapter molecules in either the TLRs or TNF-alpha signaling pathways...
  4. Lei X, Sun Z, Liu X, Jin Q, He B, Wang J. Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol. 2011;85:8811-8 pubmed publisher
    ..Notably, EV71 specifically downregulates a TRIF, TIR domain-containing adaptor inducing beta interferon (IFN-?)...
  5. Jiang Z, Zamanian Daryoush M, Nie H, Silva A, Williams B, Li X. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR . J Biol Chem. 2003;278:16713-9 pubmed
    ..Kinase inactive mutants of TAK1 (TAK1DN) and PKR (PKRDN) inhibit poly(dI.dC)-induced TLR3-mediated NFkappaB activation, suggesting that both of these kinases play important roles in this pathway. ..
  6. Xu L, Wang Y, Han K, Li L, Zhai Z, Shu H. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell. 2005;19:727-40 pubmed
    ..Our data also indicate that VISA interacts with TRIF and TRAF6 and mediates bifurcation of the TLR3-triggered NF-kappaB and IRF-3 activation pathways...
  7. Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M. Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA. J Immunol. 2007;179:6867-72 pubmed
    ..TIR) domain-containing adaptor molecule-1 (TICAM-1, also named TIR domain-containing adaptor inducing IFN-beta or TRIF), which recruits downstream signaling molecules to activate the transcription factors IFN regulatory factor 3 (IRF-..
  8. Funami K, Sasai M, Oshiumi H, Seya T, Matsumoto M. Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation. J Biol Chem. 2008;283:18283-91 pubmed publisher
    ..adaptor molecule-1 (TICAM-1, also named TIR domain-containing adaptor-inducing interferon (IFN)-beta or TRIF)) is a signaling adaptor of Toll-like receptor (TLR) 3/4 that activates the transcription factors, interferon ..
  9. Rebsamen M, Meylan E, Curran J, Tschopp J. The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. Cell Death Differ. 2008;15:1804-11 pubmed publisher
    ..virally derived double-stranded (ds) RNA, transmits downstream antiviral signaling through the TIR adaptor Trif (TICAM-1), viral RNA-sensing RIG-like helicases (RLHs) use the mitochondrial-bound CARD protein Cardif (IPS-1/MAVS/..

More Information

Publications108 found, 100 shown here

  1. Sasai M, Oshiumi H, Matsumoto M, Inoue N, Fujita F, Nakanishi M, et al. Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. J Immunol. 2005;174:27-30 pubmed
    ..domain-containing adapter molecule (TICAM-1) (also called Toll/IL-1R domain-containing adapter inducing IFN-beta (TRIF)) mediates IFN regulatory factor 3 (IRF3) phosphorylation followed by IFN-beta production...
  2. Kaiser W, Offermann M. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol. 2005;174:4942-52 pubmed
    ..proteins MyD88, TIR-domain containing adapter protein (TIRAP), TIR-domain-containing adapter-inducing IFN-beta (TRIF), TRIF-related adapter molecule (TRAM), and sterile alpha motifs and beta-catenin/armadillo repeats (SARM)...
  3. Carty M, Goodbody R, Schröder M, Stack J, Moynagh P, Bowie A. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol. 2006;7:1074-81 pubmed
    ..Activating functions have been assigned to four TIR adaptors: MyD88, Mal, TRIF and TRAM...
  4. Sasai M, Tatematsu M, Oshiumi H, Funami K, Matsumoto M, Hatakeyama S, et al. Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway. Mol Immunol. 2010;47:1283-91 pubmed publisher
    ..screening, we found three TRAF proteins TRAF1, 2 and 6, bound the N-terminal region of the TLR3/4 adaptor TICAM-1 (TRIF)...
  5. Piao W, Song C, Chen H, Diaz M, Wahl L, Fitzgerald K, et al. Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling. J Leukoc Biol. 2009;86:863-75 pubmed publisher
    ..study, we examined LPS-mediated activation of MyD88-dependent and Toll-IL-1R-containing adaptor inducing IFN-beta (TRIF)-dependent pathways emanating from TLR4 and expression of negative regulators of TLR signaling in control and ..
  6. Han C, Jin J, Xu S, Liu H, Li N, Cao X. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol. 2010;11:734-42 pubmed publisher
    ..Syk interacted with and induced tyrosine phosphorylation of MyD88 and TRIF, which led to degradation of these adaptor molecules by the E3 ubiquitin ligase Cbl-b...
  7. Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, et al. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol. 2002;169:6668-72 pubmed
    ..Here, we identified a novel TIR domain-containing molecule, named TIR domain-containing adapter inducing IFN-beta (TRIF). As is the case in MyD88 and TIRAP, overexpression of TRIF activated the NF-kappaB-dependent promoter...
  8. Fitzgerald K, McWhirter S, Faia K, Rowe D, Latz E, Golenbock D, et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol. 2003;4:491-6 pubmed
    ..Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. ..
  9. Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol. 2003;4:161-7 pubmed
    ..Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TICAM-1. This TICAM-1-dependent pathway may have a role in other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response. ..
  10. Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-li. J Immunol. 2003;171:4304-10 pubmed
    ..reported a new Toll/IL-1R (TIR)-containing molecule, named TIR domain-containing adaptor inducing IFN-beta (TRIF)...
  11. Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003;4:1144-50 pubmed
    ..pathways mediated by Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88, TIRAP and TRIF. MyD88 is a common adaptor that is essential for proinflammatory cytokine production, whereas TRIF mediates the ..
  12. Cusson Hermance N, Khurana S, Lee T, Fitzgerald K, Kelliher M. Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. J Biol Chem. 2005;280:36560-6 pubmed
    ..impaired when rip1-/- cells are treated with TNF-alpha, poly(I-C), or lipopolysaccharide, implicating Rip1 in the Trif-dependent TLR3 and TLR4 pathways...
  13. Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol. 2004;5:503-7 pubmed
    ..innate immune responses through Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88 and Trif. Analysis of Trif-deficient mice has shown that TLR3-dependent activation of the transcription factor NF-kappa B by ..
  14. Huang H, Zeng Z, Wang K, Zhang H, Wang S, Zhou W, et al. Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. World J Gastroenterol. 2015;21:2937-48 pubmed publisher
    ..lysates were subjected to immunoprecipitation with anti-Toll-IL-1R-containing adaptor inducing interferon-β (TRIF) and anti-myeloid differentiation factor 88 (MyD88), and then the immunoprecipitates were analyzed by SDS-PAGE and ..
  15. Coleman O, Lobner E, Bierwirth S, Sorbie A, Waldschmitt N, Rath E, et al. Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis. Gastroenterology. 2018;155:1539-1552.e12 pubmed publisher
    ..in the myeloid differentiation primary response gene 88 and toll-like receptor adaptor molecule 1 gene (Myd88/Trif-knockout mice)...
  16. Li M, Li H, Fang F, Deng X, Ma S. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2017;639:114-119 pubmed publisher
    ..primary response gene 88 (MyD88), toll/interleukin-1 receptor-domain containing adaptor-inducing interferon-? (TRIF) and tumour necrosis factor receptor associated factor-6 (TRAF6), and subsequently inhibited NF-?B phosphorylation...
  17. Montazeri M, Sanchez Lopez J, Caballero I, Maslehat Lay N, Elliott S, López Martín S, et al. Activation of Toll-like receptor 3 reduces actin polymerization and adhesion molecule expression in endometrial cells, a potential mechanism for viral-induced implantation failure. Hum Reprod. 2015;30:893-905 pubmed publisher
    ..occur, inhibitors were applied for Toll/interleukin-1 receptor domain-containing adaptor inducing interferon-beta (TRIF), myeloid differentiation primary response 88 (MYD88), mitogen-activated protein kinases (MAPK) and nuclear factor ..
  18. Pearson J, Giogha C, Mühlen S, Nachbur U, Pham C, Zhang Y, et al. EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation. Nat Microbiol. 2017;2:16258 pubmed publisher
    ..serine/threonine-protein kinase 3 (RIPK3), TIR-domain-containing adapter-inducing interferon-β (TRIF) and Z-DNA-binding protein 1 (ZBP1)/DNA-dependent activator of IFN-regulatory factors (DAI) that contain receptor-..
  19. Lee Y, Kim Y, Jung Y, Kim K, Kim D, Na S, et al. Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression. Exp Mol Med. 2017;49:e408 pubmed publisher
    ..in TLR4, myeloid differentiation factor 88 (MyD88) and TIR domain-containing adaptor inducing interferon-? (TRIF), we demonstrated that LPS-induced hepcidin expression by hepatocytes is regulated by its specific receptor, TLR4, ..
  20. Kinsella S, Fichtner M, Watters O, König H, Prehn J. Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation. J Neuroinflammation. 2018;15:130 pubmed publisher
    ..We elucidated a positive role of Bid in both TIR-domain-containing adapter-inducing interferon-β (TRIF)- and myeloid differentiation primary response 88 (MyD88)-dependent pathways downstream of TLR4, concurrently ..
  21. Huang N, Shaik Dasthagirisaheb Y, Lavalley M, Gibson F. Liver X receptors contribute to periodontal pathogen-elicited inflammation and oral bone loss. Mol Oral Microbiol. 2015;30:438-50 pubmed publisher
    ..gene 88 (MyD88)-independent, Toll/interleukin-1 receptor-domain-containing adapter-inducing interferon-β (TRIF)-dependent signaling affected P...
  22. He Y, Xie Z, Dai J, Cao Y, Hou J, Zheng Y, et al. Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks. Virol Sin. 2016;31:57-68 pubmed publisher
    ..3 and TLR7 were upregulated at 3-8 dpi, and that of TIR-domain-containing adapter-inducing interferon (IFN) β (TRIF) was upregulated at 21 dpi in the trachea and kidney...
  23. Wang G, Zhang M, Li Y, Zhou J, Chen L. Studying the Effect of Downregulating Autophagy-Related Gene LC3 on TLR3 Apoptotic Pathway Mediated by dsRNA in Hepatocellular Carcinoma Cells. Cancer Res Treat. 2017;49:230-245 pubmed publisher
    ..RNA (dsRNA) activated Toll-interleukin-1 receptor domain-containing adaptor inducing interferon β (TRIF) signal pathway in triggering apoptosis in hepatocellular carcinoma (HCC) cells...
  24. Takeda Y, Azuma M, Matsumoto M, Seya T. Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8(+) T cells during vaccine immunotherapy. J Exp Clin Cancer Res. 2016;35:143 pubmed publisher
    ..CD11c expression in CD8(+) T cells reflects anti-tumor CTL activity and would be a marker for immunotherapeutic efficacy in mouse models and probably cancer patients as well. ..
  25. Tatematsu M, Ishii A, Oshiumi H, Horiuchi M, Inagaki F, Seya T, et al. A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation. J Biol Chem. 2010;285:20128-36 pubmed publisher
    The Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 (TICAM-1, also called TRIF) is a signaling adaptor for TLR3 and TLR4 that activates the transcription factors IRF-3, NF-kappaB, and AP-1, leading to induction of type I ..
  26. Sancho Shimizu V, Pérez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, et al. Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. J Clin Invest. 2011;121:4889-902 pubmed publisher
    ..We report here unrelated HSE children with AR or AD TRIF deficiency...
  27. Barcelos R, Bresciani G, Rodriguez Miguelez P, Cuevas M, Soares F, Barbosa N, et al. Diclofenac pretreatment effects on the toll-like receptor 4/nuclear factor kappa B-mediated inflammatory response to eccentric exercise in rat liver. Life Sci. 2016;148:247-53 pubmed publisher
    ..TLR4, myeloid differentiation primary response gene 88 (MyD88), TIR domain-containing adaptor inducing interferon (TRIF) and p65 NF-κB subunit protein levels...
  28. Emmerich C, Bakshi S, Kelsall I, Ortiz Guerrero J, Shpiro N, Cohen P. Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun. 2016;474:452-461 pubmed publisher
    ..Here we show that Lys63/Met1-Ub hybrids are also formed rapidly when the TNFR1/TRADD, TLR3/TRIF- and NOD1/RIP2-signaling networks are activated, some of which are attached covalently to Receptor-Interacting ..
  29. Shao Y, Xu X, Li Y, Qi X, Wang K, Wu Y, et al. Paeoniflorin inhibits high glucose-induced macrophage activation through TLR2-dependent signal pathways. J Ethnopharmacol. 2016;193:377-386 pubmed publisher
    ..the HG-induced activation of MyD88-dependent pathway, but not TIR domain containing adapter inducing interferon-? (Trif) signal pathway in BMDMs...
  30. Kusaka S, Nishida A, Takahashi K, Bamba S, Yasui H, Kawahara M, et al. Expression of human cathelicidin peptide LL-37 in inflammatory bowel disease. Clin Exp Immunol. 2018;191:96-106 pubmed publisher
    ..specific for intracellular signalling proteins [Toll/IL-1R domain-containing adaptor-inducing interferon (IFN) (TRIF), tumour necrosis factor receptor-associated factor (TRAF)6, transforming growth factor β-activated kinase (TAK)1] ..
  31. Nasiri M, Saadat M, Karimi M, Azarpira N, Saadat I. Evaluating mRNA Expression Levels of the TLR4/IRF5 Signaling Axis During Hepatic Ischemia-Reperfusion Injuries. Exp Clin Transplant. 2017;: pubmed publisher
    ..The effect of the TRIF-dependent signaling pathway downstream of TLR4 in hepatic ischemia-reperfusion injury has been well established...
  32. Nakai M, Oshiumi H, Funami K, Okamoto M, Matsumoto M, Seya T, et al. Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV). Sensors (Basel). 2015;15:27160-73 pubmed publisher
    ..Here we summarize our view on the mechanism by which DCs mature to induce NK and CTL in a status of HCV infection. ..
  33. Sirskyj D, Kumar A, Azizi A. Mechanisms Underlying the Immune Response Generated by an Oral Vibrio cholerae Vaccine. Int J Mol Sci. 2016;17: pubmed publisher
    ..immune responses following oral immunization with Dukoral, comparing wild type mice with TLR-2-, TLR-4-, MyD88- and Trif-deficient mice...
  34. Peterson L, Philip N, Dillon C, Bertin J, Gough P, Green D, et al. Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis. J Immunol. 2016;197:4110-4117 pubmed
    ..This cell death requires RIPK1 kinase activity and caspase-8, which are engaged by TLR4 and the adaptor protein TRIF. Nevertheless, TLR4- and TRIF-deficient cells undergo significant apoptosis, implicating TLR4/TRIF-independent ..
  35. Gentle I, McHenry K, Weber A, Metz A, Kretz O, Porter D, et al. TIR-domain-containing adapter-inducing interferon-β (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy. FEBS J. 2017;284:1987-2003 pubmed publisher
    ..the innate immunity protein/Toll-like receptor adaptor TIR-domain-containing adapter-inducing interferon-β (TRIF) as a novel platform of fibril formation and probe signal initiation through TRIF as well as its termination in ..
  36. Shalaby K, Al Heialy S, Tsuchiya K, Farahnak S, McGovern T, Risse P, et al. The TLR4-TRIF pathway can protect against the development of experimental allergic asthma. Immunology. 2017;152:138-149 pubmed publisher
    ..and Toll, interleukin-1 receptor and resistance protein (TIR) domain-containing adaptor inducing interferon-? (TRIF) comprise the two principal limbs of the TLR signalling network...
  37. Dos Santos J, Grund L, Seibert C, Marques E, Soares A, Quesniaux V, et al. Stingray venom activates IL-33 producing cardiomyocytes, but not mast cell, to promote acute neutrophil-mediated injury. Sci Rep. 2017;7:7912 pubmed publisher
    ..to peritoneal cavities was observed in ST2-/-, TLR2/TLR4-/-, MyD88-/-, TRIF-/- and IL-17A-/- mice, and a partial reduction was observed in IL-18R-/- mice...
  38. Wang J, He G, Wang Y, Zhu Q, Chen W, Guo T. TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury. World J Gastroenterol. 2015;21:8314-25 pubmed publisher
    ..anti-myeloid differentiation gene 88 (MyD88), and anti-translocating-chain-associating membrane protein (TRIF) antibody groups...
  39. Zhao G, Lv S, Wei G, Wei J, Lin X, Huang Q. [Protective effect of asiatic acid from Potentilla chinensis on alcohol hepatic injury in rats]. Zhongguo Zhong Yao Za Zhi. 2015;40:2866-70 pubmed
    ..The expressions of NF-κB, TLR4, CD14, MyD88, TRIF and protein expression in hepatic tissues were measured by western blot...
  40. Karpus O, Hsiao C, de Kort H, Tak P, Hamann J. Intracellular delivery of poly(I:C) induces apoptosis of fibroblast-like synoviocytes via an unknown dsRNA sensor. Biochem Biophys Res Commun. 2016;477:343-9 pubmed publisher
    ..Knockdown of the downstream adaptor proteins IPS, STING, and TRIF or inhibition of TBK1 did not affect the response to intracellular poly(I:C), while knockdown of IFNAR blocked ..
  41. Huang B, Park D, Baek S. TRIF is a regulator of TLR2-induced foam cell formation. Mol Med Rep. 2016;14:3329-35 pubmed publisher
    ..In the present study, the role of toll/interleukin-1 receptor-domain-containing adaptor-inducing interferon-? (TRIF) in TLR2-mediated foam cell formation was investigated, and the importance of monocyte chemoattractant protein?1 (..
  42. Takizawa H, Fritsch K, Kovtonyuk L, Saito Y, Yakkala C, Jacobs K, et al. Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness. Cell Stem Cell. 2017;21:225-240.e5 pubmed publisher
    ..This process is mediated via TLR4-TRIF-ROS-p38, but not MyD88 signaling, and can be inhibited pharmacologically without preventing emergency ..
  43. Zou H, Su R, Ruan J, Shao H, Qian K, Ye J, et al. Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB. Sci Rep. 2017;7:7547 pubmed publisher
    ..that an interferon-independent mechanism involving Toll-IL-1-receptor domain-containing adapter-inducing IFN-α (TRIF) and nuclear factor κB (NF-κB) causes the apoptosis of MDCC-MSB1 cells...
  44. Kato K, Lillehoj E, Kim K. MUC1 regulates epithelial inflammation and apoptosis by PolyI:C through inhibition of Toll/IL-1 receptor-domain-containing adapter-inducing IFN-? (TRIF) recruitment to Toll-like receptor 3. Am J Respir Cell Mol Biol. 2014;51:446-54 pubmed publisher
    ..TLR signaling mediated through the TLR3-Toll/IL-1 receptor-domain-containing adapter-inducing IFN-? (TRIF) pathway in response to poly(I:C)...
  45. Rodriguez Miguelez P, Fernandez Gonzalo R, Collado P, Almar M, Martínez Flórez S, de Paz J, et al. Whole-body vibration improves the anti-inflammatory status in elderly subjects through toll-like receptor 2 and 4 signaling pathways. Mech Ageing Dev. 2015;150:12-9 pubmed publisher
    ..myeloid differentiation primary response gen 88 (MyD88) and TIR domain-containing adaptor inducing interferon (TRIF)-dependent pathways were analyzed. Plasma TNFα and C-reactive protein levels were also assessed...
  46. Dauletbaev N, Cammisano M, Herscovitch K, Lands L. Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-β in Airway Epithelial Cells with Minimal Costimulation of IL-8. J Immunol. 2015;195:2829-41 pubmed publisher
    ..submerged and well-differentiated), we observed that pure poly(I:C) stimulated IFN-β mainly through the TLR3/TRIF pathway and IL-8 through an unidentified pathway...
  47. Ahn S, Kim J, Gu G, Shin H, Kim A, Shim H, et al. Suppression of Toll-Like Receptor 4 Dimerization by 1-[5-Methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine. Arch Pharm (Weinheim). 2016;349:785-790 pubmed publisher
    ..factor 88 (MyD88) and the Toll/interleukin-1 receptor domain-containing adapter, inducing interferon-? (TRIF)-dependent major downstream signaling pathways...
  48. Nosratababadi R, Bagheri V, Zare Bidaki M, Hakimi H, Zainodini N, Kazemi Arababadi M. Toll like receptor 4: an important molecule in recognition and induction of appropriate immune responses against Chlamydia infection. Comp Immunol Microbiol Infect Dis. 2017;51:27-33 pubmed publisher
    ..lipopolysacharide (LPS) and subsequently activates transcription from pro-inflammatory cytokines in both MYD88 and TRIF pathways dependent manner...
  49. Rahman F, Smith A, Hayee B, Marks D, Bloom S, Segal A. Delayed resolution of acute inflammation in ulcerative colitis is associated with elevated cytokine release downstream of TLR4. PLoS ONE. 2010;5:e9891 pubmed publisher
    ..molecules under transcriptional control of the adaptor TIR-domain containing adaptor inducing interferon-beta (TRIF)...
  50. Tamaki Y, Takakubo Y, Hirayama T, Konttinen Y, Goodman S, Yamakawa M, et al. Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis. J Rheumatol. 2011;38:810-20 pubmed publisher
    ..In RA, danger-associated molecular patterns to TLR interactions may particularly drive DC to autoinflammatory and autoimmune cascades/synovitis. ..
  51. Burrows M, Volchkov P, Kobayashi K, Chervonsky A. Microbiota regulates type 1 diabetes through Toll-like receptors. Proc Natl Acad Sci U S A. 2015;112:9973-7 pubmed publisher
    ..Only MyD88- and TIR-domain containing adapter inducing IFN β (TRIF) double deficient NOD mice developed the disease...
  52. Goritzka M, Pereira C, Makris S, Durant L, Johansson C. T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R. Sci Rep. 2015;5:18533 pubmed publisher
    ..To evaluate the collective contribution of PRRs and IL-1R signalling to RSV immunity, we generated Myd88/Trif/Mavs(-/-) mice that are deficient in signalling by all TLRs, RLRs and IL-1R, as well as other cytokine receptors ..
  53. Song J, Fan H, Li H, Ding H, Lv Q, Hou S. Zingerone ameliorates lipopolysaccharide-induced acute kidney injury by inhibiting Toll-like receptor 4 signaling pathway. Eur J Pharmacol. 2016;772:108-14 pubmed publisher
    ..The expressions of Toll-like receptor 4 (TLR4), MyD88, TRIF, Nuclear factor Kappa B (NF-κB) and IκB were measured by Western blotting...
  54. Popovic Z, Embgenbroich M, Chessa F, Nordström V, Bonrouhi M, Hielscher T, et al. Hyperosmolarity impedes the cross-priming competence of dendritic cells in a TRIF-dependent manner. Sci Rep. 2017;7:311 pubmed publisher
    ..We identified TRIF as key mediator of this phenomenon...
  55. Feng Y, Zou L, Yan D, Chen H, Xu G, Jian W, et al. Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms. J Immunol. 2017;199:2106-2117 pubmed publisher
    ..was abolished in cells deficient of TLR7 or MyD88, or by a TLR7 antagonist, but remained the same in TLR3- or Trif-deficient cells. In vivo, mice i.p...
  56. Lalwani P, Raftery M, Kobak L, Rang A, Giese T, Matthaei M, et al. Hantaviral mechanisms driving HLA class I antigen presentation require both RIG-I and TRIF. Eur J Immunol. 2013;43:2566-76 pubmed publisher
    ..Our results show that hantaviruses strongly boost the HLA-I antigen presentation machinery by mechanisms that are dependent on both retinoic acid inducible gene I and TIR domain containing adaptor inducing IFN-?...
  57. Jiang L, Xu F, He W, Chen L, Zhong H, Wu Y, et al. CD200Fc reduces TLR4-mediated inflammatory responses in LPS-induced rat primary microglial cells via inhibition of the NF-κB pathway. Inflamm Res. 2016;65:521-32 pubmed publisher
    ..iNOS, MCP-1, and COX-2) was monitored by ELISA or real-time PCR, while NF-κB-related signals (MyD88, p-TAK1, TRIF, p-TBK1, p-IRF3, p-IκB, and NF-κB-P65) were assessed by real-time PCR, western blot and/or Immunofluorescent ..
  58. Brunn A, Mihelcic M, Carstov M, Feind L, Wieser E, Schmidt J, et al. Toll-Like Receptor 2, Toll-Like Receptor 4, Myeloid Differentiation Response Gene 88, and Toll-IL-1 Receptor Domain-Containing Adaptor-Inducing Interferon-? (TRIF) Selectively Regulate Susceptibility of P0106-125-Induced Murine Experimental Autoimmun. Am J Pathol. 2017;187:42-54 pubmed publisher
    ..myeloid differentiation response gene 88, and Toll-IL-1 receptor domain-containing adaptor-inducing interferon-? (TRIF), factors critically involved in the TLR signaling pathway, was studied in experimental autoimmune neuritis...
  59. Granucci F. The Family of LPS Signal Transducers Increases: the Arrival of Chanzymes. Immunity. 2018;48:4-6 pubmed publisher
    After LPS recognition, the MyD88-dependent and the TRIF-dependent pathways are consecutively activated in macrophages. Schappe et al...
  60. Parera M, Martrus G, Franco S, Clotet B, Martinez M. Canine hepacivirus NS3 serine protease can cleave the human adaptor proteins MAVS and TRIF. PLoS ONE. 2012;7:e42481 pubmed publisher
    ..antiviral signaling protein (MAVS) and Toll-IL-1 receptor domain-containing adaptor inducing interferon-beta (TRIF). The proteolytic activity of CHV NS3/4A was evaluated using a bacteriophage lambda genetic screen...
  61. Zariri A, Beskers J, van de Waterbeemd B, Hamstra H, Bindels T, van Riet E, et al. Meningococcal Outer Membrane Vesicle Composition-Dependent Activation of the Innate Immune Response. Infect Immun. 2016;84:3024-33 pubmed publisher
    ..showed reduced induction of proinflammatory cytokines interleukin-6 (IL-6) and IL-1? but not of IP-10, a typical TRIF-dependent chemokine...
  62. Bozza S, Campo S, Arseni B, Inforzato A, Ragnar L, Bottazzi B, et al. PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis. J Immunol. 2014;193:2340-8 pubmed publisher
    ..fumigatus infection. ..
  63. Han K, Su X, Xu L, Bin L, Zhang J, Shu H. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. J Biol Chem. 2004;279:15652-61 pubmed
    ..Recent studies suggest that a Toll/interleukin-1 receptor domain-containing adapter protein (TRIF) and two protein kinases (TANK-binding kinase-1 (TBK1) and IkappaB kinase (IKK)-epsilon) are critically involved in ..
  64. Takeshita F, Ishii K, Kobiyama K, Kojima Y, Coban C, Sasaki S, et al. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. Eur J Immunol. 2005;35:2477-85 pubmed
    ..and functionally counteracts with TRAF6 and Toll-IL-1 receptor (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) molecules that critically regulate TLR-mediated signaling...
  65. Kimman T, Banus S, Reijmerink N, Reimerink J, Stelma F, Koppelman G, et al. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. PLoS ONE. 2008;3:e3665 pubmed publisher
    ..We found significant associations between the PT-IgG titer and SNPs in CD14, TLR4, TOLLIP, TIRAP, IRAK3, IRAK4, TICAM1, and TNFRSF4 in one or more of the analyses...
  66. Choi Y, Im E, Pothoulakis C, Rhee S. TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5. J Biol Chem. 2010;285:21382-90 pubmed publisher
    ..Here we show that the TIR domain containing adaptor-inducing interferon-beta (TRIF), an adaptor molecule mediating TLR3 signaling and MyD88-independent signaling of TLR4, plays an inhibitory role in ..
  67. Biswas N, Liu S, Ronni T, Aussenberg S, Liu W, Fujita T, et al. The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling. PLoS ONE. 2011;6:e21153 pubmed publisher
    ..TLR4-mediated signaling, but strongly suppressed the transcriptional activation of IFN-? promoter through the TLR3-Trif-dependent pathway...
  68. Bowen W, Minns L, Johnson D, Mitchell T, Hutton M, Evans J. Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist. Sci Signal. 2012;5:ra13 pubmed publisher
    ..responses, whereas the other depends on Toll-IL-1 receptor (TIR) domain-containing adaptor inducing interferon-? (TRIF), which elicits type I interferon production...
  69. Zhang H, Rodriguez S, Wang L, Wang S, Serezani H, Kapur R, et al. Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88. Stem Cell Reports. 2016;6:940-956 pubmed publisher
    ..Using mice deficient in TLR4 downstream adapters MYD88 or TRIF, we demonstrate that both cell-autonomous and non-cell-autonomous MYD88 activation are major causes of ..
  70. Ye W, Hu M, Lei C, Zhou Q, Lin H, Sun M, et al. TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction. J Immunol. 2017;199:1856-1864 pubmed publisher
    ..Our findings uncover an additional mechanism on the termination of TLR3/4-mediated inflammatory and innate immune responses. ..
  71. Gais P, Tiedje C, Altmayr F, Gaestel M, Weighardt H, Holzmann B. TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. J Immunol. 2010;184:5842-8 pubmed publisher
    The adapter protein TRIF mediates signal transduction through TLR3 and TLR4, inducing production of type I IFNs and inflammatory cytokines...
  72. Meyer F, Ehlers E, Steadman A, Waterbury T, Cao M, Zhang L. TLR-TRIF pathway enhances the expression of KSHV replication and transcription activator. J Biol Chem. 2013;288:20435-42 pubmed publisher
    ..Toll/interleukin-1-receptor domain containing adaptor protein inducing interferon-? (TRIF) is an adaptor associated with TLR3 and TLR4 signaling, and is closely related to antiviral signaling to activate ..
  73. Jayaraman P, Devlin A, Miller J, Scholle F. The adaptor molecule Trif contributes to murine host defense during Leptospiral infection. Immunobiology. 2016;221:964-74 pubmed publisher
    ..interrogans; however, the role of the TLR adaptor molecule TIR-domain-containing adaptor-inducing interferon ? (TRIF) in the response to L. interrogans has not been previously determined...
  74. Ye Y, Yang Y, Chen C, Li Z, Jia Y, Su X, et al. Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway. Stem Cells Int. 2017;2017:5841814 pubmed publisher
    ..In addition, EA exerted an inhibitory effect on both TLR4/Myd88/NF-?B and TLR4/TRIF/NF-?B pathways, as well as the inflammatory cytokine expression in the hippocampus following TBI...
  75. Wang X, Wang Y, Liu D, Wang P, Fan D, Guan Y, et al. Elevated expression of EBV and TLRs in the brain is associated with Rasmussen's encephalitis. Virol Sin. 2017;32:423-430 pubmed publisher
    ..of Toll-like receptor 3 (TLR3), TLR9, and downstream adapter TIRdomain-containing adapter-inducing interferon-β (TRIF) in the brain tissues of 26 patients with RE and 16 control individuals using immunohistochemistry (IHC)...
  76. Zenke K, Muroi M, Tanamoto K. AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner. Cell Signal. 2018;43:32-39 pubmed publisher
    ..Toll-like receptor (TLR)-mediated MyD88-dependent and Toll/IL-1R domain-containing adaptor inducing IFN-β (TRIF)-dependent signaling by inhibiting NF-κB activation and IRF3 activity independently of its kinase activity...
  77. Kim J, Liu Y, Kulkarni R, Lee K, Dai B, Lovely G, et al. Dendritic cell-targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation. Sci Immunol. 2017;2: pubmed publisher
    ..Activation of DCs by LVs was independent of MyD88, TRIF, and MAVS, ruling out an involvement of Toll-like receptor or RIG-I-like receptor signaling...
  78. Xu H, An H, Hou J, Han C, Wang P, Yu Y, et al. Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages. Mol Immunol. 2008;45:3545-52 pubmed publisher
    ..activation of MAPKs, NF-kappaB, and IRF3, furthermore, co-transfection of PTP1B inhibits both MyD88- and TRIF-induced transcription of TNF-alpha and IFN-beta reporter genes in a dose-dependent manner...
  79. Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, et al. TRIM38 negatively regulates TLR3-mediated IFN-? signaling by targeting TRIF for degradation. PLoS ONE. 2012;7:e46825 pubmed publisher
    ..receptor 3 (TLR3)-mediated type I interferon signaling by targeting TIR domain-containing adaptor inducing IFN-? (TRIF)...
  80. Nguyen V, Chen J, Petrus M, Goldman C, Kruhlak M, Bamford R, et al. A new domain in the Toll/IL-1R domain-containing adaptor inducing interferon-β factor protein amino terminus is important for tumor necrosis factor-α receptor-associated factor 3 association, protein stabilization and interferon signaling. J Innate Immun. 2014;6:377-93 pubmed publisher
    Toll/IL-1R domain-containing adaptor inducing interferon-β (IFN-β) factor (TRIF) is a key adaptor for Toll-like receptor (TLR) 3 and TLR4 signaling...
  81. Planès R, Ben Haij N, Leghmari K, Serrero M, BenMohamed L, Bahraoui E. HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes. J Virol. 2016;90:5886-5898 pubmed publisher
    ..Using three complementary approaches, including mice deficient in the MyD88, TIRAP/MAL, or TRIF adaptor, biochemical analysis, and the use of specific small interfering RNAs (siRNAs), we demonstrated (i) that ..
  82. Ma Z, Liu J, Wu W, Zhang E, Zhang X, Li Q, et al. The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model. Cell Mol Immunol. 2017;14:997-1008 pubmed publisher
    ..HBV protein production and replication in Tlr2-/-, Tlr23479-/-, 3d/Tlr24-/-, Myd88/Trif-/- and Irak4-/- mice, which was associated with reduced HBV-specific CD8+ T-cell ..
  83. Li J, Sasaki G, Dey P, Chitchumroonchokchai C, Labyk A, McDonald J, et al. Green tea extract protects against hepatic NFκB activation along the gut-liver axis in diet-induced obese mice with nonalcoholic steatohepatitis by reducing endotoxin and TLR4/MyD88 signaling. J Nutr Biochem. 2018;53:58-65 pubmed publisher
    ..0 or 2% for 8 weeks before assessing NASH, NFκB-mediated inflammation, TLR4 and its adaptor proteins MyD88 and TRIF, circulating endotoxin, and intestinal tight junction protein mRNA expression. TLR4m mice had lower (P<...
  84. Kasumba D, Hajake T, Oh S, Kotenko S, Kato H, Fujita T. A Plant-Derived Nucleic Acid Reconciles Type I IFN and a Pyroptotic-like Event in Immunity against Respiratory Viruses. J Immunol. 2017;199:2460-2474 pubmed publisher
    ..This protection was completely absent in mice lacking both TRIF and MDA5, indicating the essential role of TLR3- and MDA5-dependent pathways...
  85. Ono J, Shime H, Takaki H, Takashima K, Funami K, Yoshida S, et al. The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice. J Biomed Sci. 2017;24:79 pubmed publisher
    ..We established Apc Min/+ Ticam1 -/- mice and their survival was compared to survival of Apc Min/+ Myd88 -/- and ..
  86. Tsai F, Homan P, Agrawal H, Misharin A, Abdala Valencia H, Haines G, et al. Bim suppresses the development of SLE by limiting myeloid inflammatory responses. J Exp Med. 2017;214:3753-3773 pubmed publisher
    ..Moreover, the toll-like receptor signaling adaptor protein TRIF (TIR-domain-containing adapter-inducing interferon-?) is essential for GN, but not systemic autoimmunity in LysM<..
  87. Shen Y, Li N, Wang J, Liu B, Lester S, Li K. TRIM56 is an essential component of the TLR3 antiviral signaling pathway. J Biol Chem. 2012;287:36404-13 pubmed publisher
    ..Rather, it correlated with a physical interaction between TRIM56 and TRIF. Deletion of the C-terminal portion of TRIM56 abrogated the TRIM56-TRIF interaction as well as the augmentation of ..
  88. Totura A, Whitmore A, Agnihothram S, Schäfer A, Katze M, Heise M, et al. Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. MBio. 2015;6:e00638-15 pubmed publisher
    ..In contrast, mice deficient in the TLR3/TLR4 adaptor TRIF are highly susceptible to SARS-CoV infection, showing increased weight loss, mortality, reduced lung function, ..
  89. Hawn T, Scholes D, Li S, Wang H, Yang Y, Roberts P, et al. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS ONE. 2009;4:e5990 pubmed publisher
    ..Although these data suggest that TLR polymorphisms are associated with adult susceptibility to UTIs, the statistical significance was modest and will require further study including validation with independent cohorts. ..
  90. Liu W, Ge M, Hu X, Lv A, Ma D, Huang X, et al. The Effects of Agaricus blazei Murill Polysaccharides on Cadmium-Induced Apoptosis and the TLR4 Signaling Pathway of Peripheral Blood Lymphocytes in Chicken. Biol Trace Elem Res. 2017;180:153-163 pubmed publisher
    ..genes (caspase-3, Bax, and Bcl-2), the mRNA levels of TLR4 and TLR4 signaling pathway-related factors (MyD88, TRIF, NF-?B, and IRF3), the TLR4 protein expression, and the concentrations of inflammatory cytokines (IL-1?, IL-6, and ..
  91. Liu T, Hu X, Wang Y, Meng L, Zhou Y, Zhang J, et al. Triazine-based covalent organic frameworks for photodynamic inactivation of bacteria as type-II photosensitizers. J Photochem Photobiol B. 2017;175:156-162 pubmed publisher
    ..Herein, we reported two covalent organic frameworks (COFs) materials, namely COFs-Trif-Benz and COF-SDU1, as effective type-II photosensitizers for photodynamic inactivation of bacteria...
  92. Zettel K, Korff S, Zamora R, Morelli A, Darwiche S, Loughran P, et al. Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice. Front Immunol. 2017;8:1672 pubmed publisher
    ..The role of TLR4 was determined using TLR4-/-, MyD88-/-, and Trif-/- C57BL/6 (B6) mice, and by in vivo administration of a TLR4-specific neutralizing monoclonal ..