TIAR

Summary

Gene Symbol: TIAR
Description: TIA1 cytotoxic granule associated RNA binding protein like 1
Alias: TCBP, TIAR, nucleolysin TIAR, T-cluster binding protein, TIA-1-related nucleolysin, aging-associated gene 7 protein
Species: human
Products:     TIAR

Top Publications

  1. Le Guiner C, Gesnel M, Breathnach R. TIA-1 or TIAR is required for DT40 cell viability. J Biol Chem. 2003;278:10465-76 pubmed
    TIA-1 and TIAR are a pair of related RNA-binding proteins which have been implicated in apoptosis. We show that chicken DT40 cells with both tia-1 alleles and one tiar allele disrupted (tia-1(-/-)tiar(-/+) cells) are viable...
  2. Liao B, Hu Y, Brewer G. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. Nat Struct Mol Biol. 2007;14:511-8 pubmed
    ..were proportional to AUF1 abundance but inversely proportional to the abundance of the ARE-binding protein TIAR, a MYC translational suppressor...
  3. Doi T, Minami T, Itoh M, Aburatani H, Kawabe Y, Kodama T, et al. An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. Biochem Biophys Res Commun. 1997;235:625-30 pubmed
    The cDNA of a T-cluster binding protein (TCBP) has been cloned using the Southwestern method...
  4. Kawakami A, Tian Q, Duan X, Streuli M, Schlossman S, Anderson P. Identification and functional characterization of a TIA-1-related nucleolysin. Proc Natl Acad Sci U S A. 1992;89:8681-5 pubmed
    ..Here we report the characterization of a cDNA encoding a TIA-1-related protein designated TIAR. The deduced amino acid sequence of TIAR reveals it to be a 42-kDa protein possessing three RNA-binding domains and ..
  5. Yu Q, Cok S, Zeng C, Morrison A. Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of T-cell-restricted intracellular antigen-related protein (TIAR). J Biol Chem. 2003;278:1579-84 pubmed
    ..MMP13) gene, the differential expression of an alternatively spliced transcript of the RNA-binding protein TIAR in human cell cultures is also critical for this post-transcriptional regulation...
  6. Iseni F, Garcin D, Nishio M, Kedersha N, Anderson P, Kolakofsky D. Sendai virus trailer RNA binds TIAR, a cellular protein involved in virus-induced apoptosis. EMBO J. 2002;21:5141-50 pubmed
    ..Here we report that tr RNA binds to a cellular protein with many links to apoptosis (TIAR) via the AU-rich sequence 5' UUUUAAAUUUU...
  7. Taupin J, Tian Q, Kedersha N, Robertson M, Anderson P. The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death. Proc Natl Acad Sci U S A. 1995;92:1629-33 pubmed
    We have determined the structure, intracellular localization, and tissue distribution of TIAR, a TIA-1-related RNA-binding protein. Two related isoforms of TIAR, migrating at 42 and 50 kDa, are expressed in primate cells...
  8. Shukla S, Dirksen W, Joyce K, Le Guiner Blanvillain C, Breathnach R, Fisher S. TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting subunit 1. J Biol Chem. 2004;279:13668-76 pubmed
    ..Here we show that T-cell inhibitor of apoptosis (TIA-1) and T-cell inhibitor of apoptosis-related (TIAR) proteins bind to the IE1...
  9. Li W, Li Y, Kedersha N, Anderson P, Emara M, Swiderek K, et al. Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication. J Virol. 2002;76:11989-2000 pubmed
    ..Virol. 70:6278-6287, 1996). In this study, p42 was purified using an RNA affinity column and identified as TIAR by peptide sequencing...

More Information

Publications74

  1. Le Guiner C, Lejeune F, Galiana D, Kister L, Breathnach R, Stevenin J, et al. TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs. J Biol Chem. 2001;276:40638-46 pubmed
    ..We show here that overexpression of TIA-1 or the related protein TIAR has little effect on splicing of several endogenous pre-mRNAs containing alternative exons, but markedly activates ..
  2. Suswam E, Nabors L, Huang Y, Yang X, King P. IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR. Int J Cancer. 2005;113:911-9 pubmed
    ..Immunoprecipitation analysis indicated that HuR, KSRP and TIAR bound to one or more loci in the 3'UTR...
  3. Kim H, Kuwano Y, Zhan M, Pullmann R, Mazan Mamczarz K, Li H, et al. Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. Mol Cell Biol. 2007;27:6806-17 pubmed
    The RNA-binding protein TIAR (related to TIA-1 [T-cell-restricted intracellular antigen 1]) was shown to associate with subsets of mRNAs bearing U-rich sequences in their 3' untranslated regions...
  4. Gesnel M, Theoleyre S, Del Gatto Konczak F, Breathnach R. Cooperative binding of TIA-1 and U1 snRNP in K-SAM exon splicing activation. Biochem Biophys Res Commun. 2007;358:1065-70 pubmed
    ..Our in vivo data, taken together with previous in vitro results, show that K-SAM splicing activation involves cooperative binding of TIA-1 and U1 snRNP to the exon's 5' splice site region. ..
  5. Mazan Mamczarz K, Lal A, Martindale J, Kawai T, Gorospe M. Translational repression by RNA-binding protein TIAR. Mol Cell Biol. 2006;26:2716-27 pubmed
    The RNA-binding protein TIAR has been proposed to inhibit protein synthesis transiently by promoting the formation of translationally silent stress granules...
  6. Cok S, Acton S, Morrison A. The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. J Biol Chem. 2003;278:36157-62 pubmed
    ..We identified four members of the protein-RNA complex as HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U (hnRNP U)...
  7. Kumar A, Swenson M, Benning M, Kielkopf C. Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution. Biochem Biophys Res Commun. 2008;367:813-9 pubmed publisher
    ..In contrast with previous assumptions, the mutated residues are buried within the hydrophobic interior of the domain, where they would be likely to destabilize the RRM fold rather than directly inhibit RNA binding. ..
  8. Izquierdo J, Valcarcel J. Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein. J Biol Chem. 2007;282:19410-7 pubmed
    TIA-1 (T-cell Intracellular Antigen 1) and TIAR (TIA-1-related protein) are RNA-binding proteins involved in the regulation of alternative pre-mRNA splicing and other aspects of RNA metabolism...
  9. Wang Z, Kayikci M, Briese M, Zarnack K, Luscombe N, Rot G, et al. iCLIP predicts the dual splicing effects of TIA-RNA interactions. PLoS Biol. 2010;8:e1000530 pubmed publisher
    ..Thus, our findings indicate that changes in splicing kinetics could mediate the distal regulation of alternative splicing. ..
  10. Zhu H, Hasman R, Young K, Kedersha N, Lou H. U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. Mol Cell Biol. 2003;23:5959-71 pubmed
    ..Here, we report the identification of TIAR as a novel player in the regulation of human calcitonin/CGRP alternative RNA processing...
  11. Aznarez I, Barash Y, Shai O, He D, Zielenski J, Tsui L, et al. A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. Genome Res. 2008;18:1247-58 pubmed publisher
    ..Since cytotoxic granule-associated RNA binding protein (TIA1) and TIA1-like 1 (TIAL1; also known as TIAR) were previously shown in vitro to bind to U-rich motifs downstream of 5' splice sites, and to facilitate 5' splice ..
  12. Dember L, Kim N, Liu K, Anderson P. Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. J Biol Chem. 1996;271:2783-8 pubmed
    TIA-1 and TIAR are two closely related RNA recognition motif (RRM) proteins which possess three RRM-type RNA binding domains (RRMs 1, 2, and 3)...
  13. Suswam E, Li Y, Mahtani H, King P. Novel DNA-binding properties of the RNA-binding protein TIAR. Nucleic Acids Res. 2005;33:4507-18 pubmed
    ..Here, we observed selective and potent inhibition of TIAR-RNP complex formation with IL-8 and VEGF 3'-untranslated regions (3'-UTRs) using thymidine-rich ..
  14. Catanzaro N, Meng X. Porcine reproductive and respiratory syndrome virus (PRRSV)-induced stress granules are associated with viral replication complexes and suppression of host translation. Virus Res. 2019;265:47-56 pubmed publisher
    ..first demonstrated that infection with PRRSV strain VR2385 induces an accumulation of the SG markers G3BP1, G3BP2, TIAR, eIF3b, and USP10 as well as mRNAs into punctate structures in the cytoplasm of infected host cells...
  15. Moujalled D, James J, Parker S, Lidgerwood G, Duncan C, Meyerowitz J, et al. Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. PLoS ONE. 2013;8:e67433 pubmed publisher
    ..Close correlation was observed between effects of these inhibitors on TDP-43, hnRNP K and TIAR, but often with different effects on HuR accumulation...
  16. Xu H, Sun H, Zhang H, Liu J, Fan F, Li Y, et al. An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling. PLoS ONE. 2015;10:e0124033 pubmed publisher
    ..A total of 6 candidate transformation suppressors including INPP4B, Sesn2, TIAR, ACRC, Nup210, LMTK3 were identified. We validated Sesn2 as the candidate of lung cancer tumor suppressor...
  17. Morozova O, Sherin P, Yurkovskaya A. Competition of singlet and triplet recombination of radical pairs in photoreactions of carboxy benzophenones and aromatic amino acids. Phys Chem Chem Phys. 2019;: pubmed publisher
    ..of radicals of 4,4'-dicarboxy benzophenone (DCBP) and ∼27% of radicals of 3,3',4,4'-tetracarboxy benzophenone (TCBP) react with histidine radicals from the triplet state of radical pairs...
  18. Kim H, Wilce M, Yoga Y, Pendini N, Gunzburg M, Cowieson N, et al. Different modes of interaction by TIAR and HuR with target RNA and DNA. Nucleic Acids Res. 2011;39:1117-30 pubmed publisher
    b>TIAR and HuR are mRNA-binding proteins that play important roles in the regulation of translation. They both possess three RNA recognition motifs (RRMs) and bind to AU-rich elements (AREs), with seemingly overlapping specificity...
  19. Geng Z, Li P, Tan L, Song H. Targeted Knockdown of RNA-Binding Protein TIAR for Promoting Self-Renewal and Attenuating Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int. 2015;2015:657325 pubmed publisher
    RNA-binding protein TIAR has been suggested to mediate the translational silencing of ARE-containing mRNAs. To analyze the functions of TIAR, we established RNAi and genetic rescue assays...
  20. Naz S, Khan R, Giddaluru J, Battu S, Vishwakarma S, Subahan M, et al. Transcriptome meta-analysis identifies immune signature comprising of RNA binding proteins in ulcerative colitis patients. Cell Immunol. 2018;334:42-48 pubmed publisher
    ..In addition, we report a novel gene signature comprising of TIA1 (T cell restricted intracellular antigen) and TIAR (TIA1 related protein; also known as TIAL1), which were found to be significantly downregulated in UC patients...
  21. Morozova O, Panov M, Fishman N, Yurkovskaya A. Electron transfer vs. proton-coupled electron transfer as the mechanism of reaction between amino acids and triplet-excited benzophenones revealed by time-resolved CIDNP. Phys Chem Chem Phys. 2018;: pubmed publisher
    ..the short-lived radicals of 4-carboxy, 4,4'-dicarboxy, and 3,3',4,4'-tetracarboxy benzophenones (4-CBP, DCBP, and TCBP, respectively) formed in their photoreaction with tyrosine were obtained from analysis of geminate CIDNP spectra...
  22. Waris S, Wilce M, Wilce J. RNA recognition and stress granule formation by TIA proteins. Int J Mol Sci. 2014;15:23377-88 pubmed publisher
    ..to SG formation are the T cell restricted intracellular antigen (TIA) proteins (TIA-1 and TIA-1 related protein (TIAR)), that both directly bind to target RNA and self-associate to seed the formation of SGs...
  23. Bley N, Lederer M, Pfalz B, Reinke C, Fuchs T, Glaß M, et al. Stress granules are dispensable for mRNA stabilization during cellular stress. Nucleic Acids Res. 2015;43:e26 pubmed publisher
    ..Here, we demonstrate that the sustained inhibition of visible SGs requires the concomitant knockdown of TIA1, TIAR and G3BP1...
  24. Sánchez Jiménez C, Ludeña M, Izquierdo J. T-cell intracellular antigens function as tumor suppressor genes. Cell Death Dis. 2015;6:e1669 pubmed publisher
    Knockdown of T-cell intracellular antigens TIA1 and TIAR in transformed cells triggers cell proliferation and tumor growth...
  25. Núñez M, Sánchez Jiménez C, Alcalde J, Izquierdo J. Long-term reduction of T-cell intracellular antigens reveals a transcriptome associated with extracellular matrix and cell adhesion components. PLoS ONE. 2014;9:e113141 pubmed publisher
    Knockdown of T-cell intracellular antigens TIA1 and TIAR contributes to a cellular phenotype characterised by uncontrolled proliferation and tumorigenesis...
  26. Soto Rifo R, Valiente Echeverría F, Rubilar P, García de Gracia F, Ricci E, Limousin T, et al. HIV-2 genomic RNA accumulates in stress granules in the absence of active translation. Nucleic Acids Res. 2014;42:12861-75 pubmed publisher
    ..Moreover, we observed that the RNA-binding protein and stress granules assembly factor TIAR associates with the gRNA to form a TIAR-HIV-2 ribonucleoprotein (TH2RNP) complex localizing diffuse in the ..
  27. Ravanidis S, Kattan F, Doxakis E. Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated Factors. Int J Mol Sci. 2018;19: pubmed publisher
    ..discusses the roles of Pumilio, Staufen, IGF2BP, FMRP, Sam68, CPEB, NOVA, ELAVL, SMN, TDP43, FUS, TAF15, and TIA1/TIAR in RNA metabolism by analyzing their specific molecular and cellular function, the neurological symptoms associated ..
  28. Thomas M, Martinez Tosar L, Loschi M, Pasquini J, Correale J, Kindler S, et al. Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes. Mol Biol Cell. 2005;16:405-20 pubmed
    ..Staufen SGs contain the poly(A)-binding protein (PABP), the RNA-binding proteins HuR and TIAR, and small but not large ribosomal subunits...
  29. Podszywalow Bartnicka P, Wolczyk M, Kusio Kobialka M, Wolanin K, Skowronek K, Nieborowska Skorska M, et al. Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation. Cell Cycle. 2014;13:3727-41 pubmed publisher
    ..We investigated 2 mRNA-binding proteins - HuR and TIAR showing specificity to AU-Rich Element (ARE) sites in 3'UTR of mRNA...
  30. Weeks A, Agnihotri S, Lymer J, Chalil A, Diaz R, Isik S, et al. Epithelial Cell Transforming 2 and Aurora Kinase B Modulate Formation of Stress Granule-Containing Transcripts from Diverse Cellular Pathways in Astrocytoma Cells. Am J Pathol. 2016;186:1674-87 pubmed publisher
    ..RNA immunoprecipitation with the known stress granule aggregates TIAR and G3BP1 was performed on astrocytoma cells, and subsequent analysis revealed that astrocytoma stress granules ..
  31. Tang S, Luo S, Ho J, Ly P, Goh E, Roca X. Characterization of the Regulation of CD46 RNA Alternative Splicing. J Biol Chem. 2016;291:14311-23 pubmed publisher
    ..This study provides insight into CD46 alternative splicing regulation with implications for its function in the immune system and for genetic disease. ..
  32. Carrascoso I, Alcalde J, Sánchez Jiménez C, González Sánchez P, Izquierdo J. T-Cell Intracellular Antigens and Hu Antigen R Antagonistically Modulate Mitochondrial Activity and Dynamics by Regulating Optic Atrophy 1 Gene Expression. Mol Cell Biol. 2017;37: pubmed publisher
    ..Knockdown of TIA1/TIAR or HuR partially reversed the expression profile of OPA1, whereas knockdown of OPA1 or overexpression of OPA1v5 ..
  33. Moujaber O, Mahboubi H, Kodiha M, Bouttier M, Bednarz K, Bakshi R, et al. Dissecting the molecular mechanisms that impair stress granule formation in aging cells. Biochim Biophys Acta Mol Cell Res. 2017;1864:475-486 pubmed publisher
    ..It requires the SG-nucleating proteins G3BP1 and TIA-1/TIAR and stress-related signaling events. To analyze SG formation, we used two independent models of somatic cell aging...
  34. Zhou Y, Fang L, Wang D, Cai K, Chen H, Xiao S. Porcine Reproductive and Respiratory Syndrome Virus Infection Induces Stress Granule Formation Depending on Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK) in MARC-145 Cells. Front Cell Infect Microbiol. 2017;7:111 pubmed publisher
    ..Impairment of SG assembly by concomitant knockdown of the SG marker proteins (TIA1, G3BP1, and TIAR) did not affect PRRSV growth, while significantly enhanced PRRSV-induced NF-κB subunit p65 phosphorylation and ..
  35. Sun Y, Dong L, Yu S, Wang X, Zheng H, Zhang P, et al. Newcastle disease virus induces stable formation of bona fide stress granules to facilitate viral replication through manipulating host protein translation. FASEB J. 2017;31:1337-1353 pubmed publisher
    ..Furthermore, the role of SGs on NDV replication was investigated by knockdown of TIA-1 and TIA-1-related (TIAR) protein, the 2 critical components involved in SG formation from the HeLa cells, followed by NDV infection...
  36. Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T. The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression. Mol Cell. 2018;69:622-635.e6 pubmed publisher
    ..Our study reveals the essential contributions of the TIA1 protein family to the fidelity of mRNA maturation, translation, and RNA-stress-sensing pathways in human cells. ..
  37. Sampuda K, Riley M, Boyd L. Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans. BMC Cell Biol. 2017;18:18 pubmed publisher
    ..oxidative stress, and starvation, but not heat shock, induce the relocalization of ubiquitin, proteasome, and the TIAR-2 protein into distinct subnuclear regions referred to as stress induced nuclear granules (SINGs)...
  38. Navratilova Z, Novosadova E, Hagemann Jensen M, Kullberg S, Kolek V, Grunewald J, et al. Expression Profile of Six RNA-Binding Proteins in Pulmonary Sarcoidosis. PLoS ONE. 2016;11:e0161669 pubmed publisher
    ..We investigated in vivo expression of six RBPs (AUF1, HuR, NCL, TIA, TIAR, PCBP2) and two inhibitors of proteolytic enzymes (RECK, PTEN) in pulmonary sarcoidosis and compared it to the ..
  39. Hou S, Kumar A, Xu Z, Airo A, Stryapunina I, Wong C, et al. Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response. J Virol. 2017;91: pubmed publisher
    ..Depletion of the SG components G3BP1, TIAR, and Caprin-1, but not TIA-1, reduced ZIKV replication...
  40. Liu L, Yue H, Liu Q, Yuan J, Li J, Wei G, et al. LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway. Oncotarget. 2016;7:15787-800 pubmed publisher
    ..By associating with the RNA-binding protein TIAR, MT1JP enhanced the translation of the master transcription factor p53, thereby regulating a series of pathways ..
  41. Fechir M, Linker K, Pautz A, Hubrich T, Kleinert H. The RNA binding protein TIAR is involved in the regulation of human iNOS expression. Cell Mol Biol (Noisy-le-grand). 2005;51:299-305 pubmed
    ..known to interact with AREs and to regulate mRNA stability is the T cell intracellular antigen-1-related protein (TIAR). In RNA binding studies TIAR displayed high affinity binding to the human iNOS 3'-UTR sequence...
  42. Singh N, Seo J, Ottesen E, Shishimorova M, Bhattacharya D, Singh R. TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy. Mol Cell Biol. 2011;31:935-54 pubmed publisher
    ..Here, we report T-cell-restricted intracellular antigen 1 (TIA1) and TIA1-related (TIAR) proteins as intron-associated positive regulators of SMN2 exon 7 splicing...
  43. Yeowell H, Walker L, Mauger D, Seth P, Garcia Blanco M. TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2. J Invest Dermatol. 2009;129:1402-11 pubmed publisher
    ..Identification of these TIA regulatory factors therefore suggests a tool to manipulate cellular LH2 levels in scleroderma so that potential intervention therapies may be identified. ..
  44. Carrascoso I, Sánchez Jiménez C, Izquierdo J. Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells. Biochem J. 2014;461:43-50 pubmed publisher
    ..Our data support the hypothesis that a concerted activation of both global and selective translational rates leads to the transition to a more proliferative status in TIA-knockdown HeLa cells. ..
  45. Lu L, Wang S, Zheng L, Li X, Suswam E, Zhang X, et al. Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. J Biol Chem. 2009;284:33989-98 pubmed publisher
    ..Here, we show that the major RNA stabilizer, Hu Antigen R (HuR), and TIA-1-related protein (TIAR) colocalize with mutant SOD1 in mouse spinal cord extracts and cultured glioma cells...
  46. Ogawa F, Kasai M, Akiyama T. A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3. Biochem Biophys Res Commun. 2005;338:771-6 pubmed
    ..Our findings suggest that DISC1 may function as a translational regulator and may be involved in stress response. ..
  47. Bossowski A, Czarnocka B, Bardadin K, Moniuszko A, Łyczkowska A, Czerwinska J, et al. Identification of chosen apoptotic (TIAR and TIA-1) markers expression in thyroid tissues from adolescents with immune and non-immune thyroid diseases. Folia Histochem Cytobiol. 2010;48:178-84 pubmed publisher
    ..in thyrocytes from patients with GD and no-toxic multinodular goitre (NTMG) in relationship with apoptotic (TIAR and TIA-1) markers...
  48. Motohashi H, Mukudai Y, Ito C, Kato K, Shimane T, Kondo S, et al. Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability. Biochem J. 2017;474:1669-1687 pubmed publisher
    ..assays revealed specific binding of the region to T-cell intracellular antigen 1 (TIA-1) and TIA-1-related protein (TIAR)...
  49. Huelgas Morales G, Silva García C, Salinas L, Greenstein D, Navarro R. The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans. G3 (Bethesda). 2016;6:1031-47 pubmed publisher
    ..of stress granules, cytoplasmic ribonucleoprotein complexes containing the conserved RNA-binding proteins TIA-1 and TIAR. The stress granule response is thought to preserve mRNA for translation when conditions improve...
  50. Wiesner D, Tar L, Linkus B, Chandrasekar A, Olde Heuvel F, Dupuis L, et al. Reversible induction of TDP-43 granules in cortical neurons after traumatic injury. Exp Neurol. 2018;299:15-25 pubmed publisher
    ..The pTDP-43 granules did not colocalize with the stress markers TIAR-1 and FUS but colocalized with FMRP (35%) and with p62 (65%), suggesting their involvement in transport granules ..
  51. Kim H, Headey S, Yoga Y, Scanlon M, Gorospe M, Wilce M, et al. Distinct binding properties of TIAR RRMs and linker region. RNA Biol. 2013;10:579-89 pubmed publisher
    The RNA-binding protein TIAR is an mRNA-binding protein that acts as a translational repressor, particularly important under conditions of cellular stress...
  52. Jin K, Li W, Nagayama T, He X, Sinor A, Chang J, et al. Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury. J Neurosci Res. 2000;59:767-74 pubmed
    T-cell restricted intracellular antigen-related protein (TIAR) is an RNA recognition motif-type RNA-binding protein that has been implicated in the apoptotic death of T-lymphocytes and retinal pigment epithelial cells...
  53. Marchese D, Botta Orfila T, Cirillo D, Rodríguez J, Livi C, Fernández Santiago R, et al. Discovering the 3' UTR-mediated regulation of alpha-synuclein. Nucleic Acids Res. 2017;45:12888-12903 pubmed publisher
    ..We identified two RBPs, ELAVL1 and TIAR, that bind with high affinity to the most abundant and translationally active 3' UTR isoform (575 nt)...
  54. Izquierdo J. Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR. Biochem Biophys Res Commun. 2006;348:703-11 pubmed
    ..revealed that the adenosine/uridine (AU)-rich element-binding proteins TIA-1 (T-cell intracellular antigen-1), TIAR (TIA-1-related protein), and HuR (Hu antigen R) interact with the beta-F1-ATPase mRNA through an AU-rich sequence ..
  55. Valiente Echeverría F, Melnychuk L, Vyboh K, Ajamian L, Gallouzi I, Bernard N, et al. eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection. Nat Commun. 2014;5:4819 pubmed publisher
    ..and even when SG assembly is forced by overexpression of Ras-GAP SH3 domain-binding protein (G3BP1) or TIAR. The overexposed loops in the amino-terminal capsid domain of Gag and host eukaryotic elongation factor 2 (eEF2) ..
  56. Carrascoso I, Sánchez Jiménez C, Izquierdo J. Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression. Mol Cancer. 2014;13:90 pubmed publisher
    ..and mouse cells with knocked down/out expression of T-cell intracellular antigen 1 (TIA1) and/or TIA1 related/like (TIAR/TIAL1) proteins and classical RNA (e.g...
  57. Reinhardt H, Hasskamp P, Schmedding I, Morandell S, van Vugt M, Wang X, et al. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell. 2010;40:34-49 pubmed publisher
    ..hnRNPA0, to stabilize Gadd45? mRNA, while p38 phosphorylates and releases the translational inhibitor TIAR. In addition, MK2 phosphorylates PARN, blocking Gadd45? mRNA degradation...
  58. Mitomi H, Ohkura Y, Yokoyama K, Sada M, Kobayashi K, Tanabe S, et al. Contribution of TIA-1+ and granzyme B+ cytotoxic T lymphocytes to cryptal apoptosis and ulceration in active inflammatory bowel disease. Pathol Res Pract. 2007;203:717-23 pubmed
    ..In conclusion, cytotoxic T lymphocytes are present in increased numbers in the mucosa of patients with active CD and UC, and local activation of IELs may contribute to mucosal damage with these diseases. ..
  59. Zhao W, Zhao J, Hou M, Wang Y, Zhang Y, Zhao X, et al. HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA. Int J Mol Sci. 2014;15:2946-58 pubmed publisher
    ..This study provides novel insight into how the alternative splicing of SIRT1 pre-mRNA is regulated, which has fundamental implications for understanding the critical and multifunctional roles of SIRT1. ..
  60. Kawai T, Lal A, Yang X, Galban S, Mazan Mamczarz K, Gorospe M. Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol. 2006;26:3295-307 pubmed
  61. Esclatine A, Taddeo B, Roizman B. Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs. J Virol. 2004;78:8582-92 pubmed
    ..Prompted by this observation, we examined the status of the ARE binding proteins tristetraprolin and TIA-1/TIAR in infected cells...
  62. Hua Y, Zhou J. Survival motor neuron protein facilitates assembly of stress granules. FEBS Lett. 2004;572:69-74 pubmed
    ..Our findings reveal a novel SMN function and possible SG involvement in the pathogenesis of spinal muscular atrophy. ..
  63. Wang X, Wang H, Li Y, Jin Y, Chu Y, Su A, et al. TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication. Biochem Biophys Res Commun. 2015;466:254-9 pubmed publisher
    ..Here, we found that T-cell-restricted intracellular antigen 1 (TIA-1), and TIA-1 related protein (TIAR) were translocated from nucleus to cytoplasm after EV71 infection and localized to the sites of viral replication...
  64. García Mauriño S, Rivero Rodríguez F, Velázquez Cruz A, Hernández Vellisca M, Díaz Quintana A, De la Rosa M, et al. RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate. Front Mol Biosci. 2017;4:71 pubmed publisher
    ..Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3' untranslated regions of mRNAs, namely ARE-RBPs...
  65. Gottschald O, Malec V, Krasteva G, Hasan D, Kamlah F, Herold S, et al. TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1? pathway. J Mol Cell Biol. 2010;2:345-56 pubmed publisher
    T-cell intracellular antigen (TIA)-1 and TIA-1-related protein (TIAR) are mRNA-binding proteins that can aggregate within granules under specific stress conditions...