Tiam1

Summary

Gene Symbol: Tiam1
Description: T cell lymphoma invasion and metastasis 1
Alias: TIAM-1, T-lymphoma invasion and metastasis-inducing protein 1, human T-lymphoma invasion and metastasis inducing TIAM1 protein
Species: human
Products:     Tiam1

Top Publications

  1. Minard M, Ellis L, Gallick G. Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells. Clin Exp Metastasis. 2006;23:301-13 pubmed
    The guanine nucleotide exchange factor Tiam1 regulates numerous biologic properties including migration and invasion...
  2. Michiels F, Habets G, Stam J, van der Kammen R, Collard J. A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature. 1995;375:338-40 pubmed
    ..We have isolated the invasion-inducing Tiam1 gene, which also encodes a protein with a DH domain...
  3. Guo X, Wang M, Jiang J, Xie C, Peng F, Li X, et al. Balanced Tiam1-rac1 and RhoA drives proliferation and invasion of pancreatic cancer cells. Mol Cancer Res. 2013;11:230-9 pubmed publisher
    b>Tiam1 is a rac1-specific guanine nucleotide exchange factor, and Tiam1-rac1 is involved in a number of cellular processes...
  4. Liu H, Shi G, Liu X, Wu H, Fan Q, Wang X. Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma. Oncol Rep. 2011;25:841-8 pubmed publisher
    Accumulating evidence has demonstrated that T-cell lymphoma invasion and metastasis 1 (Tiam1) plays an important role in the occurrence and development of several different tumors; however, to date, little research has been done to ..
  5. Wennerberg K, Ellerbroek S, Liu R, Karnoub A, Burridge K, Der C. RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem. 2002;277:47810-7 pubmed
    ..Rac1(17N) dominant-negative fusion protein inhibited the induction of lamellipodia by the Rac-specific activator, Tiam1, but not by activated RhoG...
  6. Adams H, Chen R, Liu Z, Whitehead I. Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein. Breast Cancer Res. 2010;12:R69 pubmed publisher
    T-cell lymphoma invasion and metastasis-inducing protein (Tiam1) is a Ras-related C3 botulinum toxin substrate (Rac)-specific guanine nucleotide exchange factor that was isolated based on its ability to induce a metastatic phenotype...
  7. Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, et al. CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. J Biol Chem. 2010;285:15511-22 pubmed publisher
    ..Amino acid sequence alignment revealed that Tiam1 (T-lymphoma invasion and metastasis 1), a Rac-specific guanine nucleotide exchange factor, has a type II PDZ ..
  8. Ding Y, Chen B, Wang S, Zhao L, Chen J, Ding Y, et al. Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients. Int J Cancer. 2009;124:653-8 pubmed publisher
    Little research has been done to test the usefulness of T-lymphoma invasion and metastasis 1 (Tiam1) as a prognostic marker for hepatocellular carcinoma (HCC)...
  9. Hou M, Tan L, Wang X, Zhu Y. Antisense Tiam1 down-regulates the invasiveness of 95D cells in vitro. Acta Biochim Biophys Sin (Shanghai). 2004;36:537-40 pubmed
    As a specific guanine nucleotide exchange factor of Rac1, Tiam1 (T-lymphoma invasion and metastasis inducing protein 1) is involved in a number of cellular events, such as cytoskeleton reorganization, cell adhesion, and cell migration...

More Information

Publications79

  1. Yang W, Lv S, Liu X, Liu H, Yang W, Hu F. Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma. Jpn J Clin Oncol. 2010;40:1053-9 pubmed publisher
    T-cell lymphoma invasion and metastasis 1 (Tiam1) specifically activates Rho-like GTPases (e.g...
  2. Cajanek L, Ganji R, Henriques Oliveira C, Theofilopoulos S, Konik P, Bryja V, et al. Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol Cell Biol. 2013;33:59-70 pubmed publisher
    ..Next, we show that Tiam1, a Rac1 guanosine exchange factor (GEF), is expressed in the ventral midbrain, interacts with Dvl, facilitates Dvl-..
  3. Woodcock S, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton A, et al. SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell. 2009;33:639-53 pubmed publisher
    The Rac activator Tiam1 is required for adherens junction (AJ) maintenance, and its depletion results in AJ disassembly. Conversely, the oncoprotein Src potently induces AJ disassembly and epithelial-mesenchymal transition (EMT)...
  4. Liu L, Zhang Q, Zhang Y, Wang S, Ding Y. Lentivirus-mediated silencing of Tiam1 gene influences multiple functions of a human colorectal cancer cell line. Neoplasia. 2006;8:917-24 pubmed
    T lymphoma invasion and metastasis 1 (Tiam1) is a metastasis-related gene of T lymphoma that is also involved in the metastasis of a variety of other cancers...
  5. Engers R, Mueller M, Walter A, Collard J, Willers R, Gabbert H. Prognostic relevance of Tiam1 protein expression in prostate carcinomas. Br J Cancer. 2006;95:1081-6 pubmed
    The Rac-specific guanine nucleotide exchange factor, Tiam1, plays a major role in oncogenicity, tumour invasion and metastasis but its usefulness as a prognostic marker in human cancer has not been tested yet...
  6. Crompton A, Foley L, Wood A, Roscoe W, Stokoe D, McCormick F, et al. Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands. J Biol Chem. 2000;275:25751-9 pubmed
    Rho family GTPases play roles in cytoskeletal organization and cellular transformation. Tiam1 is a member of the Dbl family of guanine nucleotide exchange factors that activate Rho family GTPases...
  7. Connolly B, Rice J, Feig L, Buchsbaum R. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. Mol Cell Biol. 2005;25:4602-14 pubmed
    The exchange factor Tiam1 regulates multiple cellular functions by activating the Rac GTPase...
  8. Du X, Wang S, Lu J, Wang Q, Song N, Yang T, et al. Clinical value of Tiam1-Rac1 signaling in primary gallbladder carcinoma. Med Oncol. 2012;29:1873-8 pubmed publisher
    b>Tiam1-Rac1 signaling plays an important role in the migration, invasion and metastasis of tumor cells. The aim of the present study was to clarify the clinical value of Tiam1 and Rac1 expression in primary gallbladder carcinoma (PGC)...
  9. Zhong D, Li Y, Peng Q, Zhou J, Zhou Q, Zhang R, et al. Expression of Tiam1 and VEGF-C correlates with lymphangiogenesis in human colorectal carcinoma. Cancer Biol Ther. 2009;8:689-95 pubmed
    To investigate the relationship between Tiam1 and lymphangiogenesis in human colorectal carcinoma (CRC) tissues, as well as the expression of VEGF-C in a CRC cell line (HCT116) after knockdown of the Tiam1 gene with RNA interference (..
  10. Stebel A, Brachetti C, Kunkel M, Schmidt M, Fritz G. Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1. Oncol Rep. 2009;21:217-22 pubmed
    ..Ras-homologous (Rho) GTPases and the Rho guanine exchange factor (GEF) T-cell lymphoma invasion and metastasis 1 (Tiam1) in breast tumor specimens (n=106) by immunohistochemistry...
  11. Liu S, Li Y, Qi W, Zhao Y, Huang A, Sheng W, et al. Expression of Tiam1 predicts lymph node metastasis and poor survival of lung adenocarcinoma patients. Diagn Pathol. 2014;9:69 pubmed publisher
    To assess the value of Tiam1 in predicting lymph node metastasis and survival after curative resection in patients with lung adenocarcinoma...
  12. Qi Y, Huang B, Yu L, Wang Q, Lan G, Zhang Q. Prognostic value of Tiam1 and Rac1 overexpression in nasopharyngeal carcinoma. ORL J Otorhinolaryngol Relat Spec. 2009;71:163-71 pubmed publisher
    This study is designed to investigate the roles of Tiam1 and Rac1 in nasopharyngeal carcinoma (NPC)...
  13. Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, et al. Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J. 2004;23:1075-88 pubmed
    ..We report here that the interaction of a Rac1-specific guanine nucleotide-exchanging factor, Tiam1, with ephrin-B1 and EphA2 mediates neurite outgrowth...
  14. Jin H, Li T, Ding Y, Deng Y, Zhang W, Yang H, et al. Methylation status of T-lymphoma invasion and metastasis 1 promoter and its overexpression in colorectal cancer. Hum Pathol. 2011;42:541-51 pubmed publisher
    ..Pharmacologic reversal of T-lymphoma invasion and metastasis 1 promoter hypomethylation may inhibit cell proliferation and migration. ..
  15. Otsuki Y, Tanaka M, Kamo T, Kitanaka C, Kuchino Y, Sugimura H. Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts. J Biol Chem. 2003;278:5132-40 pubmed
    ..We report in the present study on another protein, Tiam1, which is a specific guanine nucleotide exchange factor of Rac1 and which binds to c-Myc and modulates several of ..
  16. Buchsbaum R, Connolly B, Feig L. Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin. J Biol Chem. 2003;278:18833-41 pubmed
    b>Tiam1 is a ubiquitous guanine nucleotide exchange factor (GEF) that activates the Rac GTPase...
  17. Xu K, Rajagopal S, Klebba I, Dong S, Ji Y, Liu J, et al. The role of fibroblast Tiam1 in tumor cell invasion and metastasis. Oncogene. 2010;29:6533-42 pubmed publisher
    ..The Rac exchange factor Tiam1 is implicated in multiple signaling pathways in epithelial tumor cells and lack of Tiam1 in tumor cells retards ..
  18. Wang H, Wang J. Expression of Tiam1 in lung cancer and its clinical significance. Asian Pac J Cancer Prev. 2012;13:613-5 pubmed
    The aim of this study was to analyze T-cell lymphoma invasion and metastasis-inducing factor 1 (Tiam1) expression in lung cancer patients...
  19. Michiels F, Stam J, Hordijk P, van der Kammen R, Ruuls Van Stalle L, Feltkamp C, et al. Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation. J Cell Biol. 1997;137:387-98 pubmed
    ..The Tiam1 gene encodes an activator of Rac1, and similarly to constitutively activated (V12)Rac1, overexpression of Tiam1 in ..
  20. Shi Y, Miao R, Cheng L, Guo X, Yang B, Jing C, et al. Up-regulation of T-lymphoma and metastasis gene 1 in gastric cancer and its involvement in cell invasion and migration. Chin Med J (Engl). 2013;126:640-5 pubmed
    T-lymphoma and metastasis gene 1 (Tiam1) produces a guanine nucleotide exchange factor (GNEF) that regulates guanosine triphosphatase, which transforms guanosine diphosphate to guanosine triphosphate...
  21. Rajagopal S, Ji Y, Xu K, Li Y, Wicks K, Liu J, et al. Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). J Biol Chem. 2010;285:18060-71 pubmed publisher
    The Rac exchange factor Tiam1 is involved in diverse cell functions and signaling pathways through multiple protein interactions, raising the question of how signaling and functional specificity are achieved...
  22. Tolias K, Bikoff J, Kane C, Tolias C, Hu L, Greenberg M. The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci U S A. 2007;104:7265-70 pubmed
    ..Here, we report that the Rac1 guanine nucleotide exchange factor Tiam1 interacts with the EphB2 receptor in a kinase-dependent manner...
  23. Huang J, Ye X, Guan J, Chen B, Li Q, Zheng X, et al. Tiam1 is associated with hepatocellular carcinoma metastasis. Int J Cancer. 2013;132:90-100 pubmed publisher
    We have previously demonstrated that overexpression of T lymphoma invasion and metastasis 1 (Tiam1) is correlated with poor prognosis in patients with hepatocellular carcinoma (HCC)...
  24. Bourguignon L, Zhu H, Shao L, Chen Y. CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. J Biol Chem. 2000;275:1829-38 pubmed
    In this study we have explored the interaction between CD44 (the hyaluronic acid (HA)-binding receptor) and Tiam1 (a guanine nucleotide exchange factor) in metastatic breast tumor cells (SP1 cell line)...
  25. Bourguignon L, Zhu H, Shao L, Chen Y. Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration. J Cell Biol. 2000;150:177-91 pubmed
    b>Tiam1 (T-lymphoma invasion and metastasis 1) is one of the known guanine nucleotide (GDP/GTP) exchange factors (GEFs) for Rho GTPases (e.g., Rac1) and is expressed in breast tumor cells (e.g., SP-1 cell line)...
  26. Moriarty C, Pursell B, Mercurio A. miR-10b targets Tiam1: implications for Rac activation and carcinoma migration. J Biol Chem. 2010;285:20541-6 pubmed publisher
    ..Our analysis of potential miR-10b targets identified Tiam1 (T lymphoma invasion and metastasis 1), a guanidine exchange factor for Rac...
  27. Fleming I, Batty I, Prescott A, Gray A, Kular G, Stewart H, et al. Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1. Biochem J. 2004;382:857-65 pubmed
    Binding of the Rac1-specific guanine-nucleotide-exchange factor, Tiam1, to the plasma membrane requires the N-terminal pleckstrin homology domain...
  28. Lambert J, Lambert Q, Reuther G, Malliri A, Siderovski D, Sondek J, et al. Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol. 2002;4:621-5 pubmed
    ..Formation of active Rac-GTP is stimulated by Dbl family guanine nucleotide exchange factors (GEFs), such as Tiam1 (ref. 2)...
  29. Habets G, van der Kammen R, Stam J, Michiels F, Collard J. Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. Oncogene. 1995;10:1371-6 pubmed
    ..for invasive T-lymphoma variants, we have previously identified the murine invasion- and metastasis-inducing Tiam1 gene...
  30. Cottonham C, Kaneko S, Xu L. miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. J Biol Chem. 2010;285:35293-302 pubmed publisher
    ..We present compelling evidence that TIAM1, a guanidine exchange factor of the Rac GTPase, is a direct target of both miR-21 and miR-31...
  31. Li Y, Qi W, Shen H. [Quantitative analysis of Tiam1 expression in lung cancer and its clinical significance]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:1774-7 pubmed
    To investigate the relationship between the expression of T lymphoma invasion and metastasis inducing factor 1 (Tiam1) and the progression, metastasis, TNM stage, and histological types of lung carcinoma...
  32. Buongiorno P, Pethe V, Charames G, Esufali S, Bapat B. Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. Mol Cancer. 2008;7:73 pubmed publisher
    ..In addition, the Rac1-specific exchange factor, Tiam1, potentiated the stimulatory effects of Rac1 on the canonical Wnt pathway...
  33. Liu L, Wu D, Ding Y. Tiam1 gene expression and its significance in colorectal carcinoma. World J Gastroenterol. 2005;11:705-7 pubmed
    To explore the expression of Tiam1 gene in colorectal carcinoma and its correlation with tumor metastasis. Expressions of Tiam1 gene in 8 colorectal carcinoma cell lines were detected by reverse transcriptase-polymerase chain reaction...
  34. Panel N, Villa F, Fuentes E, Simonson T. Accurate PDZ/Peptide Binding Specificity with Additive and Polarizable Free Energy Simulations. Biophys J. 2018;114:1091-1102 pubmed publisher
    ..Their specificity is essential for cellular signaling pathways. We studied the binding of the Tiam1 PDZ domain to peptides derived from the C-termini of its Syndecan-1 and Caspr4 targets...
  35. Kowluru A. Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction. Biochem Pharmacol. 2017;132:9-17 pubmed publisher
    ..Recent pharmacological and molecular biological evidence identified Tiam1 and Vav2 as GEFs for Rac1 in promoting physiological insulin secretion...
  36. Li J, Liang S, Jin H, Xu C, Ma D, Lu X. Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells. Oncol Rep. 2012;27:1835-42 pubmed publisher
    b>Tiam1 has been implicated in the invasive phenotype of various carcinomas. However, its role in ovarian cancer remains to be elucidated, including its upstream regulatory mechanisms...
  37. Veluthakal R, Sidarala V, Kowluru A. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39:760-7 pubmed publisher
    ..Our findings provide the first evidence implicating the role of Tiam1-Rac1-Nox2 signaling pathway in the onset of spontaneous diabetes in the NOD mouse model.
  38. Birukova A, Malyukova I, Mikaelyan A, Fu P, Birukov K. Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids. J Cell Physiol. 2007;211:608-17 pubmed
    ..We studied involvement of Rac/Cdc42-specific guanine nucleotide exchange factors (GEFs) Tiam1 and betaPIX in OxPAPC-induced Rac activation, cytoskeletal remodeling, and barrier protective responses in the ..
  39. Mignon D, Panel N, Chen X, Fuentes E, Simonson T. Computational Design of the Tiam1 PDZ Domain and Its Ligand Binding. J Chem Theory Comput. 2017;13:2271-2289 pubmed publisher
    ..Here, we optimized a protein design energy function for the Tiam1 and Cask PDZ domains that combines a molecular mechanics energy, Generalized Born solvent, and an empirical ..
  40. O Toole T, Bialkowska K, Li X, Fox J. Tiam1 is recruited to β1-integrin complexes by 14-3-3ζ where it mediates integrin-induced Rac1 activation and motility. J Cell Physiol. 2011;226:2965-78 pubmed publisher
    ..We showed that GST-14-3-3ζ recruited the Rac1-GEF, Tiam1, from cell lysates through Tiam1 residues 1-182 (N(1-182) Tiam1)...
  41. Lin L, You J, Qian Y, Han Y, Xiong H, Zhu T, et al. The prognostic value of T Lymphoma Invasion and Metastasis 1 (TIAM1) expression in oral squamous cell carcinoma. J Biochem Mol Toxicol. 2017;31: pubmed publisher
    ..The aim of this study is to evaluate the expression profile of T Lymphoma Invasion and Metastasis 1 (TIAM1) in OSCC and its correlation with clinical outcomes including lymph node metastasis and recurrence...
  42. Xu K, Tian X, Oh S, Movassaghi M, Naber S, Kuperwasser C, et al. The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis. Breast Cancer Res. 2016;18:14 pubmed publisher
    ..Altering fibroblast Tiam1 expression induces changes in invasion, migration, epithelial-mesenchymal transition, and cancer stem cell ..
  43. Wang X, Zhu T, Zhou X, Wan Z. [Association of TIAM1 gene polymorphisms with Kawasaki disease and its clinical characteristics]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:1217-20 pubmed
    To investigate the association of single nucleotide polymorphisms (SNP) rs22833188 and rs2833195 in TIAM1 gene with the susceptibility to Kawasaki disease (KD) and its clinical characteristic in children...
  44. Whalley H, Porter A, Diamantopoulou Z, White G, Castañeda Saucedo E, Malliri A. Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation. Nat Commun. 2015;6:7437 pubmed publisher
    ..Kinesin-5 (Eg5) is a microtubule motor essential for centrosome separation, and Tiam1 and its substrate Rac antagonize Eg5-dependent centrosome separation in early mitosis promoting efficient ..
  45. Hu J, Wang Y, Li Y, Wang Y, Han H. [Correlation between T lymphoma invasion and metastasis 1 expression and epithelial-mesenchymal transition in human colorectal carcinomas]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:232-5 pubmed
    To investigate the relationship between T lymphoma invasion and metastasis 1 (Tiam1) and epithelial-mesenchymal transition (EMT) in human colorectal carcinomas...
  46. Zhu G, Fan Z, Ding M, Zhang H, Mu L, Ding Y, et al. An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. Oncogene. 2015;34:5971-82 pubmed publisher
    ..the accumulation of its specific guanine nucleotide exchange factor, T-cell lymphoma invasion and metastasis 1 (Tiam1) in non-small-cell lung cancer and colon cancer cells...
  47. Knezevic I, Predescu S, Neamu R, Gorovoy M, Knezevic N, Easington C, et al. Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability. J Biol Chem. 2009;284:5381-94 pubmed publisher
    ..Following PAF exposure, both Rac1 and its guanine nucleotide exchange factor Tiam1 were found associated with a membrane fraction from which they co-immunoprecipitated with PAF receptor...
  48. Gao Y, Xing J, Streuli M, Leto T, Zheng Y. Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors. J Biol Chem. 2001;276:47530-41 pubmed
    ..For example, Trio, GEF-H1, and Tiam1 are a subset of GEFs that specifically activate Rac1 but not the closely related Cdc42...
  49. Bravo Cordero J, Cordani M, Soriano S, Díez B, Muñoz Agudo C, Casanova Acebes M, et al. A novel high-content analysis tool reveals Rab8-driven cytoskeletal reorganization through Rho GTPases, calpain and MT1-MMP. J Cell Sci. 2016;129:1734-49 pubmed publisher
    ..actin and focal adhesion reorganization that revealed that Rab8 activation significantly induced Rac1 and Tiam1 to mediate cortical actin polymerization and RhoA-dependent stress fibre disassembly...
  50. Kou W, Xu X, Ji S, Chen M, Liu D, Wang K, et al. The inhibition of the effect and mechanism of vascular intimal hyperplasia in Tiam1 knockout mice. Biochem Biophys Res Commun. 2018;497:248-255 pubmed publisher
    T-Cell Lymphoma Invasion and Metastasis 1 (Tiam1) is a specific nucleotide exchange factor (GEF) that can activate Rho-like GTPase and Rac1 and regulate various cellular processes, including cell cycle progression and cell migration...
  51. Toyokawa G, Cho H, Masuda K, Yamane Y, Yoshimatsu M, Hayami S, et al. Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. Neoplasia. 2011;13:887-98 pubmed
  52. Higginbotham K, Tian Y, Gawlak G, Moldobaeva N, Shah A, Birukova A. Hepatocyte growth factor triggers distinct mechanisms of Asef and Tiam1 activation to induce endothelial barrier enhancement. Cell Signal. 2014;26:2306-16 pubmed publisher
    ..been associated with Rac-GTPase signaling pathway activated by Rac-specific guanine nucleotide exchange factor Tiam1 and leading to enhancement of intercellular adherens junctions...
  53. Liu Y, Ding Y, Huang J, Wang S, Ni W, Guan J, et al. MiR-141 suppresses the migration and invasion of HCC cells by targeting Tiam1. PLoS ONE. 2014;9:e88393 pubmed publisher
    We have demonstrated that T lymphoma invasion and metastasis 1 (Tiam1) gene is associated with the poor prognosis of patients with hepatocellular carcinoma (HCC), and we used a computational approach to identify miR-141 as a Tiam1-..
  54. Vaughan L, Tan C, Chapman A, Nonaka D, Mack N, Smith D, et al. HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion. Cell Rep. 2015;10:88-102 pubmed publisher
    ..Here, we uncover a role for HUWE1 in cell migration and invasion through degrading the RAC activator TIAM1, implying an additional function in malignant progression...
  55. Buchsbaum R, Connolly B, Feig L. Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. Mol Cell Biol. 2002;22:4073-85 pubmed
    b>Tiam1 and Ras-GRF1 are guanine nucleotide exchange factors (GEFs) that activate the Rac GTPase...
  56. Desai L, White S, Waters C. Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation. J Biol Chem. 2010;285:4511-9 pubmed publisher
    ..Expression of constitutively active PI3K stimulated translocation of Tiam1 to the membrane, increased Rac1 activity, and increased wound healing of airway epithelial cells...
  57. Yoo S, Shin J, Park S. EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor. Mol Cells. 2010;29:603-9 pubmed publisher
    ..More importantly, down-regulation of Tiam-1 resulted in inefficient endocytosis of EphA8-ephrinA5 complexes. These results suggest that Tiam-1 plays a role in clathrin-dependent endocytosis of EphA8-ephrinA5 complexes. ..
  58. Diamantopoulou Z, White G, Fadlullah M, Dreger M, Pickering K, Maltas J, et al. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell. 2017;31:621-634.e6 pubmed publisher
    Aberrant WNT signaling drives colorectal cancer (CRC). Here, we identify TIAM1 as a critical antagonist of CRC progression through inhibiting TAZ and YAP, effectors of WNT signaling...
  59. Mo L, Wang H, Huang G, Zhao H, Kuang G. [Correlation between expression of the Tiam1 gene and the invasion and metastasis in nasopharyngeal carcinoma]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005;19:785-7 pubmed
    To study the relation between T lymphoma invasion/metastasis1 (Tiam1) gene and nasopharyngeal carcinoma progression...
  60. Liu X, Speckhard D, Shepherd T, Sun Y, Hengel S, Yu L, et al. Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure. 2016;24:2053-2066 pubmed publisher
    ..Here we used the Tiam1 PDZ domain and an engineered variant (QM PDZ) with broadened specificity to investigate the role of structure and ..
  61. Chen J, Deng Y, Xie S, Ding Y. [Effect of Tiam-l gene silencing on human colorectal carcinoma cell line SW480 metastasis in nude mice observed by real-time whole-body fluorescence imaging]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:756-9 pubmed
    ..Both SW480/EGFP(+) and SW480/ EGFP(+)/Tiam-1(-) cells stably expressed EGFP, and Tiam1 gene expression was reduced in SW480/EGFP(+)Tiam-1(-) to 30% of the expression level in SW480/EGFP(+) cells...
  62. Li Z, Yu X, Wang Y, Shen J, Wu W, Liang J, et al. By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth. Oncotarget. 2015;6:17559-69 pubmed
    ..We identified T lymphoma invasion and metastasis 1 (TIAM1) gene as potential target of miR-329. MiR-329 levels inversely correlated with TIAM1 expression in GC...
  63. Sanmartín E, Yáñez Y, Fornés Ferrer V, Zugaza J, Cañete A, Castel V, et al. TIAM1 variants improve clinical outcome in neuroblastoma. Oncotarget. 2017;8:45286-45297 pubmed publisher
    ..Our results reveal that genetic variants in TIAM1 gene associate with better clinical outcome, suggesting a role for these TIAM1 variants in preventing progression ..
  64. Perrin F, Boisset G, Docquier M, Schaad O, Descombes P, Kato A. No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model. Hum Mol Genet. 2005;14:3309-20 pubmed
    ..This is the first description of the gene profile of SOD1(G93A) motoneurons during disease progression and unexpectedly, no widespread induction of cell death-associated genes was detected in motoneurons of SOD1(G93A) mice. ..
  65. Zhou H, Kann M, Mallory E, Yang Y, Bugshan A, Binmadi N, et al. Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma. Neoplasia. 2017;19:65-74 pubmed publisher
  66. Kowluru R, Kowluru A, Veluthakal R, Mohammad G, Syed I, Santos J, et al. TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Diabetologia. 2014;57:1047-56 pubmed publisher
    ..In this study we assessed the role of T cell lymphoma invasion and metastasis (TIAM1), a guanine nucleotide exchange factor for RAC1, in RAC1 and NOX2 activation and the onset of mitochondrial ..
  67. Subramanian N, Navaneethakrishnan S, Biswas J, Kanwar R, Kanwar J, Krishnakumar S. RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastoma. PLoS ONE. 2013;8:e70422 pubmed publisher
    T lymphoma invasion and metastasis protein (Tiam1) is up-regulated in variety of cancers and its expression level is related to metastatic potential of the type of cancer...
  68. Otsuki Y, Tanaka M, Yoshii S, Kawazoe N, Nakaya K, Sugimura H. Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1. Proc Natl Acad Sci U S A. 2001;98:4385-90 pubmed
    ..nm23H1 and Rho-family GTPases, nm23H1 was shown to be associated with a Rac1-specific nucleotide exchange factor, Tiam1, by interaction with its amino-terminal region in extracts from the cells expressing exogenous Tiam1 and from ..
  69. Xu Z, Gakhar L, Bain F, Spies M, Fuentes E. The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain. J Biol Chem. 2017;292:17777-17793 pubmed publisher
    T-cell lymphoma invasion and metastasis 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifically activates the Rho-family GTPase Rac1 in response to upstream signals, thereby regulating cellular processes ..
  70. Li B, Song Y, Liu T, Cui Y, Jiang Y, Xie Z, et al. miRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and 9. Oncol Rep. 2013;29:1932-8 pubmed publisher
    ..Computational in silico analysis predicted that T-cell lymphoma invasion and metastasis 1 (TIAM1) is a target gene of miR-22...