Gene Symbol: TIA-1
Description: TIA1 cytotoxic granule associated RNA binding protein
Alias: TIA-1, WDM, nucleolysin TIA-1 isoform p40, nucleolysin TIA-1, T-cell-restricted intracellular antigen-1, p40-TIA-1 (containing p15-TIA-1)
Species: human
Products:     TIA-1

Top Publications

  1. Tian Q, Streuli M, Saito H, Schlossman S, Anderson P. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. Cell. 1991;67:629-39 pubmed
    ..Both natural and recombinant TIA-1 were found to induce DNA fragmentation in digitonin permeabilized thymocytes, suggesting that these molecules may be the granule components responsible for inducing apoptosis in CTL targets. ..
  2. Tian Q, Taupin J, Elledge S, Robertson M, Anderson P. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. J Exp Med. 1995;182:865-74 pubmed
    ..Our results introduce Fast and TIA-1 as components of a molecular cascade involved in signaling Fas-mediated apoptosis. ..
  3. Dember L, Kim N, Liu K, Anderson P. Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. J Biol Chem. 1996;271:2783-8 pubmed
    ..5 to 5 kilobases. In contrast, RRM 1 does not affinity-precipitate cellular RNA. The inability of RRM 1 to interact with RNA may be due to the presence of negatively charged amino acids within the RNP 1 octamer. ..
  4. Kawakami A, Tian Q, Streuli M, Poe M, Edelhoff S, Disteche C, et al. Intron-exon organization and chromosomal localization of the human TIA-1 gene. J Immunol. 1994;152:4937-45 pubmed
    ..Granule-associated serine proteases that have been implicated in cytolytic lymphocyte killing (granzyme A and granzyme B) were unable to cleave TIA-1, suggesting that processing may occur before TIA-1 enters the cytotoxic granule. ..
  5. Singh N, Seo J, Ottesen E, Shishimorova M, Bhattacharya D, Singh R. TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy. Mol Cell Biol. 2011;31:935-54 pubmed publisher
    ..Our findings expand the scope of TIA1/TIAR in genome-wide regulation of alternative splicing under normal and pathological conditions. ..
  6. Cruz Gallardo I, Aroca A, Persson C, Karlsson B, Díaz Moreno I. RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions. J Biol Chem. 2013;288:25986-94 pubmed publisher
    ..The auxiliary role of the C-terminal RRM3 domain in TIA-1 RNA recognition is poorly understood, and this work provides insight into its binding mechanisms. ..
  7. Izquierdo J, Valcarcel J. Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing. J Biol Chem. 2007;282:1539-43 pubmed
    ..Taken together, the results connect Fas signaling with the activity of splicing factors that modulate Fas alternative splicing, suggesting the existence of an autoregulatory loop that could serve to amplify Fas responses. ..
  8. Izquierdo J, Alcalde J, Carrascoso I, Reyes R, Ludeña M. Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growth. Biochem J. 2011;435:337-44 pubmed publisher
    ..Taken together, these results are consistent with a role for TIA proteins as growth/tumour-suppressor genes. ..
  9. Carrascoso I, Sánchez Jiménez C, Izquierdo J. Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression. Mol Cancer. 2014;13:90 pubmed publisher
    ..Once again steady-state levels of mouse ACTB mRNA remained unchanged. Collectively, these results suggest that TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells. ..

More Information

Publications127 found, 100 shown here

  1. Mocellin S, Provenzano M, Lise M, Nitti D, Rossi C. Increased TIA-1 gene expression in the tumor microenvironment after locoregional administration of tumor necrosis factor-alpha to patients with soft tissue limb sarcoma. Int J Cancer. 2003;107:317-22 pubmed
  2. Gottschald O, Malec V, Krasteva G, Hasan D, Kamlah F, Herold S, et al. TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1? pathway. J Mol Cell Biol. 2010;2:345-56 pubmed publisher
    ..In sum, rapid and severe hypoxia caused co-aggregation of TIAR/TIA-1 and these proteins suppressed HIF-1? expression. ..
  3. Aroca A, Díaz Quintana A, Díaz Moreno I. A structural insight into the C-terminal RNA recognition motifs of T-cell intracellular antigen-1 protein. FEBS Lett. 2011;585:2958-64 pubmed publisher
    ..The ?(1) hardly affects the thermal stability of RRM3. On the contrary, RRM2 destabilises RRM3, indicating that both modules are tumbling together, which may influence the RNA binding activity of TIA-1. ..
  4. Förch P, Puig O, Martínez C, Seraphin B, Valcarcel J. The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites. EMBO J. 2002;21:6882-92 pubmed
  5. Zuccato E, Buratti E, Stuani C, Baralle F, Pagani F. An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing. J Biol Chem. 2004;279:16980-8 pubmed
    ..The TIA-1-mediated alternative usage of the 3'-splice sites, which depends on the composition of the unusual TGmTn element, represents a new mechanism of splicing regulation by TIA-1. ..
  6. Izquierdo J, Valcarcel J. Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein. J Biol Chem. 2007;282:19410-7 pubmed
    ..Taken together, the results reveal distinct functional properties of TIA-1 isoforms and the existence of a regulatory network that controls isoform expression. ..
  7. McAlinden A, Liang L, Mukudai Y, Imamura T, Sandell L. Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA. J Biol Chem. 2007;282:24444-54 pubmed
    ..This suggests a potentially novel, dual role for TIA-1 in shuttling between DNA and RNA ligands to co-regulate COL2A1 expression at the level of transcription and pre-mRNA alternative splicing. ..
  8. Wang Z, Kayikci M, Briese M, Zarnack K, Luscombe N, Rot G, et al. iCLIP predicts the dual splicing effects of TIA-RNA interactions. PLoS Biol. 2010;8:e1000530 pubmed publisher
    ..Thus, our findings indicate that changes in splicing kinetics could mediate the distal regulation of alternative splicing. ..
  9. Kumar A, Swenson M, Benning M, Kielkopf C. Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution. Biochem Biophys Res Commun. 2008;367:813-9 pubmed publisher
    ..In contrast with previous assumptions, the mutated residues are buried within the hydrophobic interior of the domain, where they would be likely to destabilize the RRM fold rather than directly inhibit RNA binding. ..
  10. Bauer W, Heath J, Jenkins J, Kielkopf C. Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1. J Mol Biol. 2012;415:727-40 pubmed publisher
    ..Further implications for U1-C recruitment by the adjacent TIA-1 binding sites of the fas pre-mRNA and the bent TIA-1 shape, which organizes the N- and C-termini on the same side of the protein, are discussed. ..
  11. Carrascoso I, Sánchez Jiménez C, Izquierdo J. Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells. Biochem J. 2014;461:43-50 pubmed publisher
    ..Our data support the hypothesis that a concerted activation of both global and selective translational rates leads to the transition to a more proliferative status in TIA-knockdown HeLa cells. ..
  12. Förch P, Puig O, Kedersha N, Martinez C, Granneman S, Seraphin B, et al. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing. Mol Cell. 2000;6:1089-98 pubmed
  13. Cok S, Acton S, Morrison A. The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. J Biol Chem. 2003;278:36157-62 pubmed
    ..Therefore, we propose that HuR binds to the proximal region of the 3'-UTR of COX-2 following stimulation by IL-1beta and increases the expression of COX-2 mRNA by facilitating its transport out of the nucleus. ..
  14. Lopez de Silanes I, Galban S, Martindale J, Yang X, Mazan Mamczarz K, Indig F, et al. Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol. 2005;25:9520-31 pubmed
    ..In summary, we report a signature motif present in mRNAs that associate with TIA-1 and provide support to the notion that TIA-1 represses the translation of target transcripts. ..
  15. Aznarez I, Barash Y, Shai O, He D, Zielenski J, Tsui L, et al. A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. Genome Res. 2008;18:1247-58 pubmed publisher
    ..Based on our results, we estimate that approximately 15% of alternative cassette exons are regulated by TIA1/TIAL1 via U-rich intronic elements. ..
  16. Yamasaki S, Stoecklin G, Kedersha N, Simarro M, Anderson P. T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAs. J Biol Chem. 2007;282:30070-7 pubmed
    ..These results suggest that TIA-1-induced polysome disassembly is required for enhanced mRNA decay and that TIA-1-induced translational silencing promotes the decay of selected mRNAs. ..
  17. Samson M, Ly K, Tournier B, Janikashvili N, Trad M, Ciudad M, et al. Involvement and prognosis value of CD8(+) T cells in giant cell arteritis. J Autoimmun. 2016;72:73-83 pubmed publisher
    ..This study demonstrates the implication and the prognostic value of CD8(+) T-cells in GCA and suggests that CD8(+) T-cells are recruited within the vascular wall through an interaction between CXCR3 and its ligands. ..
  18. Gu X, Chen Y, Wei Q, Cao B, Ou R, Yuan X, et al. Mutation screening of the TIA1 gene in Chinese patients with amyotrophic lateral sclerosis/frontotemporal dementia. Neurobiol Aging. 2018;68:161.e1-161.e3 pubmed publisher
    ..The mutation frequency of TIA1 was 0.14% (1/721) in Chinese sALS patients, which suggests that TIA1 mutation is an uncommon genetic cause for ALS in the Chinese population. ..
  19. Carrascoso I, Sánchez Jiménez C, Silion E, Alcalde J, Izquierdo J. A Heterologous Cell Model for Studying the Role of T-Cell Intracellular Antigen 1 in Welander Distal Myopathy. Mol Cell Biol. 2019;39: pubmed publisher
    Welander distal myopathy (WDM) is a muscle dystrophy characterized by adult-onset distal muscle weakness, prevalently impacting the distal long extensors of the hands and feet...
  20. Meng X, Xiang Y. RNA granules associated with SAMD9-mediated poxvirus restriction are similar to antiviral granules in composition but do not require TIA1 for poxvirus restriction. Virology. 2019;529:16-22 pubmed publisher
    ..Our data show that TIA1 is not universally antiviral against poxviruses and support a model that the RNA granules are formed as the result of untranslated mRNA accumulation in viral DNA factories. ..
  21. Koelzer V, Dawson H, Andersson E, Karamitopoulou E, Masucci G, Lugli A, et al. Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome. Transl Res. 2015;166:207-17 pubmed publisher
    ..A combined profile of MHC-I/CD8/TIA1 improves the prognostic value of antitumoral effector cells and should be preferred to a single marker approach. ..
  22. Cruz A, Valera F, Carenzi L, Chahud F, Barros G, Elias J. Orbital and central nervous system extension of nasal natural killer/T-cell lymphoma. Ophthalmic Plast Reconstr Surg. 2014;30:20-3 pubmed publisher
    ..NKTL is a polymorphous disease. Extraocular muscle involvement and perineural spread are overlooked features that explain dissemination of the tumor to both the orbit and the central nervous system. ..
  23. Canioni D, Deau Fischer B, Taupin P, Ribrag V, Delarue R, Bosq J, et al. Prognostic significance of new immunohistochemical markers in refractory classical Hodgkin lymphoma: a study of 59 cases. PLoS ONE. 2009;4:e6341 pubmed publisher
    ..These novel cHL markers could be used in association with clinical parameters to identify newly diagnosed patients with favorable or unfavorable prognosis and to better tailor treatment for different risk groups. ..
  24. Xu D, Song L, Wang H, Xu X, Wang T, Lu L. Proteomic analysis of cellular protein expression profiles in response to grass carp reovirus infection. Fish Shellfish Immunol. 2015;44:515-24 pubmed publisher
    ..This study provides useful information on the proteomic and cellular stress granule pathway's responses to GCRV infection, which adds to our understanding of viral pathogenesis. ..
  25. Mackenzie I, Nicholson A, Sarkar M, Messing J, Purice M, Pottier C, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 2017;95:808-816.e9 pubmed publisher
    ..Moreover, TDP-43 in SGs became less mobile and insoluble. The identification of TIA1 mutations in ALS/FTD reinforces the importance of RNA metabolism and SG dynamics in ALS/FTD pathogenesis. ..
  26. An L, Harrison P. The evolutionary scope and neurological disease linkage of yeast-prion-like proteins in humans. Biol Direct. 2016;11:32 pubmed publisher
    ..Reviewed by Istvan Simon and Alexander Schleiffer. For the full reviews, please go to the Reviewers' comments section. ..
  27. Motohashi H, Mukudai Y, Ito C, Kato K, Shimane T, Kondo S, et al. Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability. Biochem J. 2017;474:1669-1687 pubmed publisher
    ..Thus, we here report the specific interactions between these elements in the post-transcriptional regulation of the TPD52 gene. ..
  28. Suzuki E, Tsutsumi A, Sugihara M, Mamura M, Goto D, Matsumoto I, et al. Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis. Int J Mol Med. 2006;18:273-8 pubmed
  29. Uluer E, Inan S, Ozbilgin K, Karaca F, Dicle N, Sancı M. The role of hypoxia related angiogenesis in uterine smooth muscle tumors. Biotech Histochem. 2015;90:102-10 pubmed publisher
    ..Angiogenesis could trigger and accelerate tumor development; therefore, anti-angiogenic therapy could be useful for treatment of tumors. ..
  30. Song L, Wang H, Wang T, Lu L. Sequestration of RNA by grass carp Ctenopharyngodon idella TIA1 is associated with its positive role in facilitating grass carp reovirus infection. Fish Shellfish Immunol. 2015;46:442-8 pubmed publisher
    ..Taken together, our results suggested that cellular CiTIA1 might facilitate GCRV replication through sequestrating and protecting viral RNA from degradation. ..
  31. Tak H, Eun J, Kim J, Park S, Kim C, Ji E, et al. T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor. Cell Death Differ. 2017;24:49-58 pubmed publisher
    ..Taken together, our results indicate that TIA-1 is a novel factor that facilitates mitochondrial dynamics by enhancing MFF expression and contributes to mitochondrial dysfunction. ..
  32. Naz S, Khan R, Giddaluru J, Battu S, Vishwakarma S, Subahan M, et al. Transcriptome meta-analysis identifies immune signature comprising of RNA binding proteins in ulcerative colitis patients. Cell Immunol. 2018;334:42-48 pubmed publisher
  33. Wigington C, Jung J, Rye E, Belauret S, Philpot A, Feng Y, et al. Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1). J Biol Chem. 2015;290:3468-87 pubmed publisher
  34. Waris S, García Mauriño S, Sivakumaran A, Beckham S, Loughlin F, Gorospe M, et al. TIA-1 RRM23 binding and recognition of target oligonucleotides. Nucleic Acids Res. 2017;45:4944-4957 pubmed publisher
    ..Together our data support a specific mode of TIA-1 RRM23 interaction with target oligonucleotides consistent with the role of TIA-1 in binding RNA to regulate gene expression. ..
  35. Yang X, Wang M, Lin B, Yao D, Li J, Tang X, et al. miR-487a promotes progression of gastric cancer by targeting TIA1. Biochimie. 2018;154:119-126 pubmed publisher
    ..Overall, our results reveal that TIA1 is a tumor suppressor gene and is directly regulated by miR-487a in GC, which may offer new therapeutic targets for GC treatment. ..
  36. Sugihara M, Tsutsumi A, Suzuki E, Wakamatsu E, Suzuki T, Ogishima H, et al. Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis. Arthritis Rheum. 2007;56:2160-9 pubmed
    ..Differences in ABP gene expression may affect TNFalpha gene expression. A higher TIA-1:HuR expression ratio might correlate with the response to infliximab therapy. ..
  37. Huang S, Liu N, Li H, Zhao J, Su L, Zhang Y, et al. TIA1 interacts with annexin A7 in regulating vascular endothelial cell autophagy. Int J Biochem Cell Biol. 2014;57:115-22 pubmed publisher
    ..Moreover, we found that ABO increased TIA1 protein level, co-localization of ANXA7 and TIA1, and ATG13 expression in the aortic endothelium of apoE(-/-) mice. These data highlighted the new role of TIA1 phosphorylation in autophagy. ..
  38. Gong Y, Hewett J. Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1. Neuroscience. 2018;373:37-51 pubmed publisher
  39. Ishibashi Y, Matsuzono E, Yokoyama F, Ohara Y, Sugai N, Seki H, et al. A case of lymphomatoid gastropathy: a self-limited pseudomalignant natural killer (NK)-cell proliferative disease mimicking NK/T-cell lymphomas. Clin J Gastroenterol. 2013;6:287-90 pubmed publisher
    ..It is important that endoscopists consider this rare entity in the differential diagnosis, and excessive treatment should be avoided. ..
  40. Ravanidis S, Kattan F, Doxakis E. Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated Factors. Int J Mol Sci. 2018;19: pubmed publisher
  41. Ma X, Wang H, Ji J, Xu W, Sun Y, Li W, et al. Hippo signaling promotes JNK-dependent cell migration. Proc Natl Acad Sci U S A. 2017;114:1934-1939 pubmed publisher
  42. Acquaah Mensah G, Taylor R. Brain in situ hybridization maps as a source for reverse-engineering transcriptional regulatory networks: Alzheimer's disease insights. Gene. 2016;586:77-86 pubmed publisher
    ..Thus, this approach of harnessing brain region-specific ISH data represents a rare opportunity for gleaning unique etiological insights for diseases such as AD. ..
  43. Gal J, Kuang L, Barnett K, Zhu B, Shissler S, Korotkov K, et al. ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics. Acta Neuropathol. 2016;132:563-76 pubmed publisher
    ..In summary, the aberrant mutant SOD1-G3BP1 interaction affects stress granule dynamics, suggesting a potential link between pathogenic SOD1 mutations and RNA metabolism alterations in ALS. ..
  44. Schimmer B, Cordova M. Corticotropin (ACTH) regulates alternative RNA splicing in Y1 mouse adrenocortical tumor cells. Mol Cell Endocrinol. 2015;408:5-11 pubmed publisher
  45. Burgess H, Mohr I. Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS. J Virol. 2018;92: pubmed publisher
    ..We show that dsRNA is localized to SGs and that SGs can function to promote PKR activation in the context of a DNA virus infection, but we find no evidence to support their importance for interferon induction during HSV-1 infection. ..
  46. Dixon D, Balch G, Kedersha N, Anderson P, Zimmerman G, Beauchamp R, et al. Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J Exp Med. 2003;198:475-81 pubmed
    ..These findings implicate that TIA-1 functions as a translational silencer of COX-2 expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia. ..
  47. Sánchez Jiménez C, Ludeña M, Izquierdo J. T-cell intracellular antigens function as tumor suppressor genes. Cell Death Dis. 2015;6:e1669 pubmed publisher
    ..Remarkably, low expressions of TIA1 and TIAR correlate with poor prognosis in patients with lung squamous cell carcinoma. These findings strongly support the concept that TIA proteins act as tumor suppressor genes. ..
  48. Mensch A, Meinhardt B, Bley N, Huttelmaier S, Schneider I, Stoltenburg Didinger G, et al. The p.S85C-mutation in MATR3 impairs stress granule formation in Matrin-3 myopathy. Exp Neurol. 2018;: pubmed publisher
    ..In summary, p.S85C mutation in matrin-3 affects the response to cellular stress by impairing stress granule formation and dynamics. This might contribute to cellular damage and progression of dystrophy in muscle of Matrin-3 myopathy. ..
  49. Fujita K, Ito H, Nakano S, Kinoshita Y, Wate R, Kusaka H. Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease. Acta Neuropathol. 2008;116:439-45 pubmed publisher
    ..Moreover, the BIs were not immunopositive for TDP-43. Our results imply that translation attenuation could be involved in the processes of BI formation in this disorder. ..
  50. Zheng D, Wang R, Ding Q, Wang T, Xie B, Wei L, et al. Cellular stress alters 3'UTR landscape through alternative polyadenylation and isoform-specific degradation. Nat Commun. 2018;9:2268 pubmed publisher
    ..Together, our data reveal a global, 3'UTR-based mRNA stability control in stressed cells and indicate that APA can function as an adaptive mechanism to preserve mRNAs in response to stress. ..
  51. López Lerma I, Peñate Y, Gallardo F, Marti R, Mitxelena J, Bielsa I, et al. Subcutaneous panniculitis-like T-cell lymphoma: Clinical features, therapeutic approach, and outcome in a case series of 16 patients. J Am Acad Dermatol. 2018;79:892-898 pubmed publisher
    ..The median follow-up time was 14 months. The 5-year disease-specific survival rate was 85.7%. This was a retrospective study. SPTCL has an excellent prognosis. Immunosuppressive agents can be considered for first-line treatment. ..
  52. Yu G, Gao Z, Huang X. ALK-positive anaplastic large cell lymphoma with an unusual alveolar growth pattern. Int J Clin Exp Pathol. 2014;7:9086-9 pubmed
    ..She is alive in good condition up to the present. Our case is biologically similar to the conventional ALK-positive ALCLs and may just represent an unusual morphological appearance. ..
  53. Bai Y, Dong Z, Shang Q, Zhao H, Wang L, Guo C, et al. Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density Lipoprotein or High-Fat Diet. PLoS ONE. 2016;11:e0159568 pubmed publisher
    ..Collectively, our data suggest that Pdcd4 as a crucial regulator in SGs induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases. ..
  54. Micheletti R, Plaisance I, Abraham B, Sarre A, Ting C, Alexanian M, et al. The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. Sci Transl Med. 2017;9: pubmed publisher
  55. Acquaah Mensah G, Agu N, Khan T, Gardner A. A regulatory role for the insulin- and BDNF-linked RORA in the hippocampus: implications for Alzheimer's disease. J Alzheimers Dis. 2015;44:827-38 pubmed publisher
    ..In addition, a functional mapping scheme using activity and interaction data affirmed the same network links to RORA. Thus, RORA emerges as a gene with a probable central role in the AD pathology/etiology. ..
  56. Zhang K, Liu Q, Shen D, Tai H, Fu H, Liu S, et al. Genetic analysis of TIA1 gene in Chinese patients with amyotrophic lateral sclerosis. Neurobiol Aging. 2018;67:201.e9-201.e10 pubmed publisher
    ..We found a novel heterozygous missense mutation (c.973A>G, p.N325D) in a sporadic ALS patient, which suggests that TIA1 LCD mutations are not common in Chinese ALS/ALS-FTD. ..
  57. Peng Q, Schork N, Wilhelmsen K, Ehlers C. Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population. Am J Med Genet B Neuropsychiatr Genet. 2017;174:435-450 pubmed publisher
  58. Nguyen H, Van Broeckhoven C, van der Zee J. ALS Genes in the Genomic Era and their Implications for FTD. Trends Genet. 2018;34:404-423 pubmed publisher
    ..In light of this observation, we discuss the oligogenic architecture of ALS. To end, we highlight emerging key molecular processes and opportunities for therapy. ..
  59. Blaker Y, Spetalen S, Brodtkorb M, Lingjaerde O, Beiske K, Østenstad B, et al. The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era. Br J Haematol. 2016;175:102-14 pubmed publisher
    ..Scores of several T-cell subset markers from the combined patient cohorts were predictive for transformation, especially CD4 and CD57. ..
  60. Zhou Y, Fang L, Wang D, Cai K, Chen H, Xiao S. Porcine Reproductive and Respiratory Syndrome Virus Infection Induces Stress Granule Formation Depending on Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK) in MARC-145 Cells. Front Cell Infect Microbiol. 2017;7:111 pubmed publisher
    ..Taken together, our results demonstrate that PRRSV induces SG formation via a PERK-dependent pathway and that SGs are involved in the signaling pathway of the PRRSV-induced inflammatory response in MARC-145 cells. ..
  61. Nguyen T, Frater J, Klein J, Chen L, Bartlett N, Foyil K, et al. Expression of TIA1 and PAX5 in Classical Hodgkin Lymphoma at Initial Diagnosis May Predict Clinical Outcome. Appl Immunohistochem Mol Morphol. 2016;24:383-91 pubmed publisher
    ..024), although only 2/74 cases were shown to be negative for this marker, suggesting that the tumor microenvironment and a transcription factor crucial for B-cell development are critical biological determinants of the disease course. ..
  62. Niu Z, Pontifex C, Berini S, Hamilton L, Naddaf E, Wieben E, et al. Myopathy With SQSTM1 and TIA1 Variants: Clinical and Pathological Features. Front Neurol. 2018;9:147 pubmed publisher
  63. McDonald K, Aulas A, Destroismaisons L, Pickles S, Beleac E, Camu W, et al. TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Hum Mol Genet. 2011;20:1400-10 pubmed publisher
    ..Thus, mutations in TDP-43 are mechanistically divergent. Finally, the cellular function of TDP-43 extends beyond splicing and places TDP-43 as a participant of the central cellular response to stress and an active player in RNA storage. ..
  64. Brand P, Dyck P, Liu J, Berini S, Selcen D, Milone M. Distal myopathy with coexisting heterozygous TIA1 and MYH7 Variants. Neuromuscul Disord. 2016;26:511-5 pubmed publisher
    ..Furthermore, the proband's childhood-onset distal leg weakness and sister's cardiomyopathy suggest that MYH7 p.Arg1820Gln likely affects function, favoring a digenic etiology of the myopathy. ..
  65. Apicco D, Ash P, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, et al. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018;21:72-80 pubmed publisher
    ..We propose a model in which dysfunction of the translational stress response leads to tau-mediated pathology. ..
  66. Vanderweyde T, Apicco D, Youmans Kidder K, Ash P, Cook C, Lummertz da Rocha E, et al. Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell Rep. 2016;15:1455-1466 pubmed publisher
    ..Pharmacological interventions that prevent SG formation also inhibit tau pathophysiology. These studies suggest that the pathophysiology of tauopathy requires an intimate interaction with RNA-binding proteins. ..
  67. Anderson P, Nagler Anderson C, O BRIEN C, Levine H, Watkins S, Slayter H, et al. A monoclonal antibody reactive with a 15-kDa cytoplasmic granule-associated protein defines a subpopulation of CD8+ T lymphocytes. J Immunol. 1990;144:574-82 pubmed
    ..Taken together, our data suggest that TIA-1 is a cytolytic granule associated protein that may define a subpopulation of resting CD8+ T lymphocytes possessing cytolytic potential. ..
  68. Furukawa Y, Kaneko K, Matsumoto G, Kurosawa M, Nukina N. Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases. J Neurosci. 2009;29:5153-62 pubmed publisher
    ..We thus propose that Htt aggregates act as an intracellular hub for the cross-seeded fibrillation of Q/N-rich AIPs and that a cross-seeding reaction is a molecular origin to cause diverse pathologies in a polyglutamine disease. ..
  69. Carrascoso I, Alcalde J, Sánchez Jiménez C, González Sánchez P, Izquierdo J. T-Cell Intracellular Antigens and Hu Antigen R Antagonistically Modulate Mitochondrial Activity and Dynamics by Regulating Optic Atrophy 1 Gene Expression. Mol Cell Biol. 2017;37: pubmed publisher
    ..Collectively, these results provide molecular insights into the antagonistic functions of TIA1b/TIARb and HuR in mitochondrial activity dynamics and suggest that their balance might contribute to mitochondrial physiopathology. ..
  70. Budak G, Dash S, Srivastava R, Lachke S, Janga S. Express: A database of transcriptome profiles encompassing known and novel transcripts across multiple development stages in eye tissues. Exp Eye Res. 2018;168:57-68 pubmed publisher
    ..It will allow a wild-type context for the detailed analysis of targeted gene-knockout mouse ocular defect models and facilitate the prioritization of candidate genes from Exome-seq data of eye disease patients. ..
  71. Hamdollah Zadeh M, Amin E, Hoareau Aveilla C, Domingo E, Symonds K, Ye X, et al. Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance. Mol Oncol. 2015;9:167-78 pubmed publisher
  72. Díaz Muñoz M, Kiselev V, Le Novère N, Curk T, Ule J, Turner M. Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells. Nat Commun. 2017;8:530 pubmed publisher
    ..Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent manner. ..
  73. González Almela E, Williams H, Sanz M, Carrasco L. The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells. Front Microbiol. 2018;9:207 pubmed publisher
    ..We conclude that eIF2, eIF4A, eIF2A, and eIF2D do not participate in the initiation of translation of HCV mRNA. ..
  74. Parekh V, Shim E, Knapp C, Hughey L, Elmets C, McKay K. Primary Cutaneous T-cell Lymphoma With Coexpression of T-Cell Receptors αβ and γδ. Am J Dermatopathol. 2016;38:66-72 pubmed publisher
    ..The disease showed partial response to systemic chemotherapy with development of new plaques, but these new lesions have regressed with radiation therapy. ..
  75. Yuan Z, Jiao B, Hou L, Xiao T, Liu X, Wang J, et al. Mutation analysis of the TIA1 gene in Chinese patients with amyotrophic lateral sclerosis and frontotemporal dementia. Neurobiol Aging. 2018;64:160.e9-160.e12 pubmed publisher
    ..Our findings broaden the known mutational spectrum in patients with ALS and further confirm TIA1 as a novel causative gene of ALS. ..
  76. Huang S, Lu W, Ge D, Meng N, Li Y, Su L, et al. A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells. Autophagy. 2015;11:2172-83 pubmed publisher
    ..Thus, NUPR1 and TIA1 may control the level of TGFB2-OT1, and TGFB2-OT1 bound to MIR3960, MIR4488 and MIR4459, which targeted CERS1, NAT8L, and LARP1, respectively, the key proteins involved in autophagy and inflammation. ..
  77. Zlobec I, Karamitopoulou E, Terracciano L, Piscuoglio S, Iezzi G, Muraro M, et al. TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer. PLoS ONE. 2010;5:e14282 pubmed publisher
    ..The prognostic effect of CD8+ TILs is confounded by the presence of TIA-1+ which translates into improved risk stratification for approximately 35% of all patients with MMR-proficient colorectal cancers. ..
  78. Hu S, Li J, Xu F, Mei S, Le Duff Y, Yin L, et al. SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation. PLoS Genet. 2015;11:e1005367 pubmed publisher
    ..Together, these data reveal a new mechanism for SAMHD1 to control LINE-1 by activating cellular stress granule pathway. ..
  79. Hashimoto S, Yamamoto S, Ogasawara N, Sato T, Yamamoto K, Katoh H, et al. Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production. PLoS ONE. 2016;11:e0161793 pubmed publisher
    ..Our results provide insight into the relationship between SGs and IFN production induced by MuV infection. ..
  80. Dinh P, Das A, Franco R, Pattnaik A. Heterogeneous nuclear ribonucleoprotein K supports vesicular stomatitis virus replication by regulating cell survival and cellular gene expression. J Virol. 2013;87:10059-69 pubmed publisher
  81. Howell M, Ottesen E, Singh N, Anderson R, Seo J, Sivanesan S, et al. TIA1 is a gender-specific disease modifier of a mild mouse model of spinal muscular atrophy. Sci Rep. 2017;7:7183 pubmed publisher
    ..Our findings implicate a protein factor as a gender-specific modifier of a mild mouse model of SMA. ..
  82. Klar J, Sobol M, Melberg A, Mäbert K, Ameur A, Johansson A, et al. Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing. Hum Mutat. 2013;34:572-7 pubmed publisher
    Welander distal myopathy (WDM) is an adult onset autosomal dominant disorder characterized by distal limb weakness, which progresses slowly from the fifth decade...
  83. Eisinger Mathason T, Andrade J, Groehler A, Clark D, Muratore Schroeder T, Pasic L, et al. Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival. Mol Cell. 2008;31:722-36 pubmed publisher
    ..Hence, RSK2 is a pivotal factor linking the stress response to survival and proliferation. ..
  84. Subramaniam K, Ooi L, Hui K. Transcriptional down-regulation of IGFBP-3 in human hepatocellular carcinoma cells is mediated by the binding of TIA-1 to its AT-rich element in the 3'-untranslated region. Cancer Lett. 2010;297:259-68 pubmed publisher
  85. Pedrotti S, Busà R, Compagnucci C, Sette C. The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res. 2012;40:1021-32 pubmed publisher
    ..Thus, our findings identify RBM11 as a novel tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. ..
  86. Tak H, Kang H, Ji E, Hong Y, Kim W, Lee E. Potential use of TIA-1, MFF, microRNA-200a-3p, and microRNA-27 as a novel marker for hepatocellular carcinoma. Biochem Biophys Res Commun. 2018;497:1117-1122 pubmed publisher
  87. Pearce L, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, et al. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J. 2007;405:513-22 pubmed
    ..Protor-1 is a novel Rictor-binding subunit of mTORC2, but further work is required to establish its role. ..
  88. Wang X, Wang H, Li Y, Jin Y, Chu Y, Su A, et al. TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication. Biochem Biophys Res Commun. 2015;466:254-9 pubmed publisher
    ..Our results suggest that TIA-1 and TIAR are two new host factors that interact with 5-UTR of EV71 genome and positively regulate viral replication. ..
  89. Hirsch Reinshagen V, Pottier C, Nicholson A, Baker M, Hsiung G, Krieger C, et al. Clinical and neuropathological features of ALS/FTD with TIA1 mutations. Acta Neuropathol Commun. 2017;5:96 pubmed publisher
    ..Increased numbers of round eosinophilic and Lewy-body like inclusions in lower motor neurons may be a distinctive feature of ALS caused by TIA1 mutations. ..
  90. Esclatine A, Taddeo B, Roizman B. Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs. J Virol. 2004;78:8582-92 pubmed
    ..The results indicate that the Vhs-dependent degradation of ARE-containing RNAs correlates with the transactivation, cytoplasmic accumulation, and persistence of tristetraprolin in infected cells. ..
  91. Tang H, Huang Y, Chen J, Yu C, Huang A. Cellular protein TIA-1 regulates the expression of HBV surface antigen by binding the HBV posttranscriptional regulatory element. Intervirology. 2008;51:203-9 pubmed publisher
    ..Down-expression of HBs antigen induced by TIA-1 was detected both in the HepG2.2.15 cell line and in HBs-PRE transient expression cells. These data demonstrated that TIA-1 inhibits HBs expression by interacting with PRE. ..
  92. Milne K, Köbel M, Kalloger S, Barnes R, Gao D, Gilks C, et al. Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. PLoS ONE. 2009;4:e6412 pubmed publisher
    ..Host immune responses to EOC vary widely according to histological subtype and the extent of residual disease. TIA-1, FoxP3 and CD20 emerge as new positive prognostic factors in high-grade serous EOC from optimally debulked patients. ..