thromboxane A2 receptor

Summary

Gene Symbol: thromboxane A2 receptor
Description: thromboxane A2 receptor
Alias: BDPLT13, TXA2-R, thromboxane A2 receptor, prostanoid TP receptor
Species: human

Top Publications

  1. ncbi Cloning and expression of cDNA for a human thromboxane A2 receptor
    M Hirata
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Nature 349:617-20. 1991
  2. ncbi Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor
    M K Raychowdhury
    Harvard Thorndike Laboratories, Department of Medicine Cardiovascular Division, Beth Israel Hospital, Boston, Massachusetts 02215
    J Biol Chem 269:19256-61. 1994
  3. pmc Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation
    T Hirata
    Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan
    J Clin Invest 97:949-56. 1996
  4. ncbi Thromboxane A2 receptor gene polymorphism is associated with the serum concentration of cat-specific immunoglobulin E as well as the development and severity of asthma in Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, SAR, China
    Pediatr Allergy Immunol 13:10-7. 2002
  5. ncbi The mechanism of oxidative stress stabilization of the thromboxane receptor in COS-7 cells
    François Valentin
    Department of Biological Sciences, Imperial College, Exhibition Road, London SW7 2AZ, United Kingdom
    J Biol Chem 279:8316-24. 2004
  6. ncbi Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma
    S H Kim
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    Clin Exp Allergy 35:585-90. 2005
  7. pmc The G12 family of G proteins as a reporter of thromboxane A2 receptor activity
    Li Zhang
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Mol Pharmacol 69:1433-40. 2006
  8. ncbi Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers
    Pierre Fontana
    INSERM Unité 765, Hôpital Européen Georges Pompidou AP HP, Paris, France
    Thromb Haemost 96:356-60. 2006
  9. ncbi Homologous desensitization of signalling by the beta (beta) isoform of the human thromboxane A2 receptor
    Leanne P Kelley-Hickie
    School of Biomolecular and Biomedical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochim Biophys Acta 1761:1114-31. 2006
  10. ncbi Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes
    Masako Sasaki
    Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba 6 3, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Prostaglandins Other Lipid Mediat 83:237-49. 2007

Research Grants

  1. Joshua A Boyce; Fiscal Year: 2016
  2. Thrombin signaling in Hemostatis and thrombosis
    Shaun R Coughlin; Fiscal Year: 2010
  3. STRUCTURE & FUNCTION RELATIONSHIP: PROSTANOID RECEPTORS
    Ke He Ruan; Fiscal Year: 2008
  4. Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthase
    Ke He Ruan; Fiscal Year: 2009
  5. Pregnane X Receptor as a Regulator of Multi-Drug Resistance in Prostate Cancer
    Daotai Nie; Fiscal Year: 2008
  6. CALCIUM AND ENDOCYTOTIC MEMBRANE RETRIEVAL
    Nevin Lambert; Fiscal Year: 2003
  7. Regulation of G-protein signaling in CNS neurons
    Nevin Lambert; Fiscal Year: 2006
  8. NEVIN ALAN LAMBERT; Fiscal Year: 2016

Scientific Experts

Detail Information

Publications150 found, 100 shown here

  1. ncbi Cloning and expression of cDNA for a human thromboxane A2 receptor
    M Hirata
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Nature 349:617-20. 1991
    ..Using a stable analogue of this compound we recently purified the human platelet thromboxane A2 receptor to apparent homogeneity...
  2. ncbi Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor
    M K Raychowdhury
    Harvard Thorndike Laboratories, Department of Medicine Cardiovascular Division, Beth Israel Hospital, Boston, Massachusetts 02215
    J Biol Chem 269:19256-61. 1994
    ..This finding of a new TxA2 receptor in endothelium suggests that a family of these receptors may result from alternative splicing of the cytoplasmic (carboxyl) tail...
  3. pmc Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation
    T Hirata
    Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan
    J Clin Invest 97:949-56. 1996
    ....
  4. ncbi Thromboxane A2 receptor gene polymorphism is associated with the serum concentration of cat-specific immunoglobulin E as well as the development and severity of asthma in Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, SAR, China
    Pediatr Allergy Immunol 13:10-7. 2002
    ..This marker is also associated with the extent of allergic sensitization to cat, as well as with reduced FEV1 and FVC values...
  5. ncbi The mechanism of oxidative stress stabilization of the thromboxane receptor in COS-7 cells
    François Valentin
    Department of Biological Sciences, Imperial College, Exhibition Road, London SW7 2AZ, United Kingdom
    J Biol Chem 279:8316-24. 2004
    ..Stabilization of the TXA(2)Rbeta by translocation from a degradative compartment, i.e. the ER, can account for the augmentation of receptor density observed in vivo...
  6. ncbi Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma
    S H Kim
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    Clin Exp Allergy 35:585-90. 2005
    The thromboxane A2 receptor (TBXA2R) is a receptor for a potent bronchoconstrictor, TBXA2 which is known to be related to bronchial asthma and myocardial infarction...
  7. pmc The G12 family of G proteins as a reporter of thromboxane A2 receptor activity
    Li Zhang
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Mol Pharmacol 69:1433-40. 2006
    ..We explore here, using the thromboxane A2 receptor TPalpha, the ability of G12 and G13 to report differences in the potency and efficacy of receptor ligands...
  8. ncbi Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers
    Pierre Fontana
    INSERM Unité 765, Hôpital Européen Georges Pompidou AP HP, Paris, France
    Thromb Haemost 96:356-60. 2006
    b>Thromboxane A2 receptor (TP) is an important actor in vascular physiology and plays a crucial role in the platelet activation process...
  9. ncbi Homologous desensitization of signalling by the beta (beta) isoform of the human thromboxane A2 receptor
    Leanne P Kelley-Hickie
    School of Biomolecular and Biomedical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochim Biophys Acta 1761:1114-31. 2006
    ....
  10. ncbi Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes
    Masako Sasaki
    Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba 6 3, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Prostaglandins Other Lipid Mediat 83:237-49. 2007
    ..These results suggest that TP beta binds to alpha 7 and PA28 gamma, and the cell-surface expression of TP beta is lower than that of TP alpha through the negative regulation of its membrane traffic by proteasomes...
  11. doi Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells
    Xiuling Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Carcinogenesis 30:1606-13. 2009
    ..These results provide strong evidence that Nurr1 plays a significant role in cell proliferation and may mediate TP agonist-induced proliferation in lung cancer cells...
  12. doi Association of thromboxane A2 receptor (TBXA2R) gene polymorphism in patients with aspirin-intolerant acute urticaria
    N S Palikhe
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, South Korea
    Clin Exp Allergy 41:179-85. 2011
    The thromboxane A2 receptor (TBXA2R) is a potent broncho- and vaso-constrictor and is associated with leukotriene synthesis. Polymorphisms in the TBXA2R gene have been linked to atopy, asthma, and atopic dermatitis...
  13. ncbi Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor
    M K Raychowdhury
    J Biol Chem 270:7011. 1995
  14. pmc Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder
    T Hirata
    Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan
    J Clin Invest 94:1662-7. 1994
    ..These results suggest that the Arg60 to Leu mutation is responsible for the disorder. Moreover, dominant inheritance of the disorder suggests the possibility that the mutation produces a dominant negative TXA2 receptor...
  15. ncbi Characterization and chromosomal mapping of the human thromboxane A2 receptor gene
    R M Nüsing
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    J Biol Chem 268:25253-9. 1993
    ..No additional exon in intron 2 was detectable, indicating that a single type of thromboxane A2 receptor protein is encoded by this gene...
  16. ncbi Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites
    C D Funk
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232
    Mol Pharmacol 44:934-9. 1993
    ..An antibody directed toward the third intracellular loop of the thromboxane receptor was able to immunoprecipitate native thromboxane receptor in solubilized membranes from human erythroleukemia cells and transfected cells...
  17. ncbi The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha
    B T Kinsella
    Department of Biochemistry, University College Dublin, Ireland
    J Pharmacol Exp Ther 281:957-64. 1997
    ..These results demonstrate that the TP alpha isoform functionally couples with either Gq or G11 in vivo, whether activated by a PG/TXA2 analog or by the F2 isoprostane 8-epi PGF2 alpha...
  18. ncbi Genetic variants of the receptors for thromboxane A2 and IL-4 in atopic dermatitis
    Keiko Tanaka
    Experimental Medicine Unit, University of Wales Swansea, Swansea SA2 8PP, United Kingdom
    Biochem Biophys Res Commun 292:776-80. 2002
    ..These results suggest TXA2 receptor polymorphism strongly interacts with IL-4R alpha polymorphism as a major determinant of high serum immunoglobulin E levels in AD...
  19. ncbi Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation
    Jeanne M Manganello
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:124-30. 2003
    ..4). These results therefore suggest that PKA blocks Rho activation by phosphorylation of Galpha(13) Thr(203)...
  20. ncbi Identification of residues important for ligand binding of thromboxane A2 receptor in the second extracellular loop using the NMR experiment-guided mutagenesis approach
    Shui Ping So
    Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 278:10922-7. 2003
    ..This information facilitates the understanding of the molecular mechanism of thromboxane A(2) binding to the important receptor and its signal transduction...
  21. ncbi The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin
    Helen M Reid
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 278:51190-202. 2003
    In humans, thromboxane A2 signals through two thromboxane A2 receptor (TP) isoforms termed TP alpha and TP beta...
  22. ncbi Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3
    Anthony W Ashton
    Department of Medicine Cardiology and Molecular Pharmacology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Circ Res 94:735-42. 2004
    ....
  23. ncbi Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration
    Anthony W Ashton
    Department of Medicine Cardiology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Circ Res 95:372-9. 2004
    ..These data further support a role for antagonism of TP activation in enhancing the angiogenic response in tissues exposed to elevated TXA2 levels in which revascularization is important...
  24. ncbi IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma
    Soo Jong Hong
    Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea
    J Allergy Clin Immunol 115:758-63. 2005
    ..The relationship between IL-5 and TBXA2R gene polymorphisms and pulmonary function in children with asthma has rarely been examined...
  25. ncbi Oligomerization of the alpha and beta isoforms of the thromboxane A2 receptor: relevance to receptor signaling and endocytosis
    Geneviève Laroche
    Service de Rhumatologie, Faculté de Médecine and Centre de Recherche Clinique, Universite de Sherbrooke, Fleurimont, QC, Canada J1H 5N4
    Cell Signal 17:1373-83. 2005
    ....
  26. ncbi 15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells
    Adrian T Coyle
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    FEBS J 272:4754-73. 2005
    ..Moreover, these data highlight a further link between enhanced risk of cardiovascular disease in diabetes mellitus associated with increased synthesis and action of thromboxane A2 (TXA2)...
  27. ncbi Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein
    Fadi T Khasawneh
    Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois 60612
    J Biol Chem 281:26951-65. 2006
    ..In summary, these results identify key amino acids (in particular Asp(193)) involved in TPR ligand coordination. These findings also demonstrate that TPR-specific ligands interact with different residues in the ligand-binding pocket...
  28. pmc Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling
    Stephen J Wilson
    Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 352:397-403. 2007
    ..Augmented isoprostane signaling was similarly observed in HEK 293 cell transiently transfected with TPalpha and TPbeta. These results indicate that TPalpha/TPbeta dimerization enhances isoprostane-mediated signal transduction...
  29. ncbi Relationship between the thromboxane A2 receptor gene and susceptibility to cerebral infarction
    Yoshiyuki Kaneko
    Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 29:665-71. 2006
    ..0%) than in the non-CI group (17.7%). These results suggest that specific SNPs and haplotypes may have utility as genetic markers for the risk of CI and that TP or a neighboring gene is associated with the increased susceptibility to CI...
  30. pmc Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide
    Miao Zhang
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Circ Res 102:328-37. 2008
    b>Thromboxane A2 receptor (TPr) stimulation induces cellular hypertrophy in vascular smooth muscle cells (VSMCs); however, regulation of VSMC hypertrophy remains poorly understood...
  31. pmc A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis
    Andrew D Mumford
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Blood 115:363-9. 2010
    ..Our demonstration that the D304N substitution causes clinically significant platelet dysfunction by reducing ligand binding establishes the importance of the NPXXY motif for TxA(2)R function in vivo...
  32. doi Thromboxane receptor alpha mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells
    Jingyan Wei
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Lung Cancer 69:26-32. 2010
    ..However, PI 3-kinase and protein kinase C had minimal contribution. These results indicate that activation of the TPalpha induces the expression of VEGF through multiple signaling pathways...
  33. doi Light on the structure of thromboxane A₂receptor heterodimers
    Francesca Fanelli
    Department of Chemistry, Dulbecco Telethon Institute, University of Modena and Reggio Emilia, Via Campi 183, 41100 Modena, Italy
    Cell Mol Life Sci 68:3109-20. 2011
    ....
  34. pmc Identification of an interaction between the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1: implications for prostate cancer
    Elizebeth C Turner
    School of Biomolecular and Biomedical Sciences, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 286:15440-57. 2011
    ....
  35. doi WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex
    Andréane Cartier
    Service de Rhumatologie, Departement de Medecine, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Institut de Pharmacologie de Sherbrooke and Centre de Recherche Clinique Etienne Lebel, Sherbrooke, QC J1H 5N4, Canada
    J Cell Sci 124:3292-304. 2011
    ..We report that WDR36 acts as a new scaffold protein tethering a G-protein-coupled receptor, Gαq and PLCβ in a signalling complex...
  36. pmc Site-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4
    Raja Chakraborty
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 7:e29996. 2012
    The human thromboxane A2 receptor (TP), belongs to the prostanoid subfamily of Class A GPCRs and mediates vasoconstriction and promotes thrombosis on binding to thromboxane (TXA2)...
  37. ncbi Characterization of the 5' untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP). Differential promoter utilization by the TP isoforms
    Adrian T Coyle
    Department of Biochemistry, University College Dublin, Ireland
    Eur J Biochem 269:4058-73. 2002
    ....
  38. ncbi Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation
    Stephen J Wilson
    Center for Experimental Therapeutics, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    J Biol Chem 279:53036-47. 2004
    ..Thus, IP/TPalpha dimerization was coincident with TP-cAMP generation, promoting a "PGI(2)-like" cellular response to TP activation. This represents a previously unknown mechanism by which IP may limit the cellular effects of TP...
  39. ncbi Involvement of actin in agonist-induced endocytosis of the G protein-coupled receptor for thromboxane A2: overcoming of actin disruption by arrestin-3 but not arrestin-2
    Geneviève Laroche
    Service de Rhumatologie, Departement de Medecine, Faculté de Médecine and Centre de Recherche Clinique, Universite de Sherbrooke, Quebec, Canada
    J Biol Chem 280:23215-24. 2005
    ..Our data provide new evidence that the actin cytoskeleton plays an essential role in TPbeta endocytosis. Furthermore, our work suggests the existence of actin-dependent and -independent arrestin-mediated pathways of endocytosis...
  40. ncbi The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11
    Emilie Hamelin
    Service de Rhumatologie, Faculté de Médecine and Centre de Recherche Clinique CHUS, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 280:36195-205. 2005
    ..is a determinant factor in controlling the recycling to the cell surface of the beta-isoform of the thromboxane A2 receptor (TPbeta) following its internalization...
  41. doi Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho
    Daotai Nie
    Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine and SimmonsCooper Cancer Institute, Springfield, Illinois 62794, USA
    Cancer Res 68:115-21. 2008
    ..Taken together, the data suggest that TPs are expressed in prostate cancer and activation of TPs regulates prostate cancer cell motility and cytoskeleton reorganization through activation of Rho...
  42. doi Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries
    Hardip Sandhu
    Department of Clinical Experimental Research, Glostrup Research Institute, Glostrup University Hospital, Denmark
    Eur J Pharmacol 644:128-37. 2010
    ..Contractile responses by activation of endothelin receptor type A and type B, serotonin receptor 5-HT(1B), prostanoid TP receptor, and angiotensin II receptor type 1 and type 2 were investigated...
  43. ncbi Nitric oxide regulation of TP receptor-mediated pulmonary vasoconstriction in the anesthetized, open-chest rat
    J P Valentin
    Centre de Recherche Pierre Fabre, Division of Cardiovascular Diseases, Castres, France
    Eur J Pharmacol 317:335-42. 1996
    ....
  44. ncbi Losartan prevents thromboxane A2/prostanoid (TP) receptor mediated increase in microvascular permeability in the rat
    J P Valentin
    Division of Cardiovascular Diseases, Centre de Recherche Pierre Fabre, Castres, France
    Am J Hypertens 10:1058-63. 1997
    ....
  45. doi Mechanism of the prostanoid TP receptor agonist U46619 for inducing emesis in the ferret
    Kelvin K W Kan
    Department of Pharmacology, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    Naunyn Schmiedebergs Arch Pharmacol 378:655-61. 2008
    ..Metoclopramide probably has a mechanism of action to prevent U46619-induced emesis via 5-HT(4) receptor activation and NK(1) tachykinin receptor antagonists could be useful to prevent emesis induced by TP receptor activation in man...
  46. ncbi Orchidectomy increases the formation of prostanoids and modulates their role in the acetylcholine-induced relaxation in the rat aorta
    Aina Martorell
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    Cardiovasc Res 77:590-9. 2008
    ..This study examines the effect of endogenous male sex hormones on thromboxane A2 (TXA2), prostaglandin (PG) I2, PGF(2 alpha), and PGE I2 release, as well as their role in acetylcholine (ACh)-mediated relaxation in the aorta...
  47. doi Presynaptic BK type Ca(2+)-activated K(+) channels are involved in prostanoid TP receptor-mediated inhibition of noradrenaline release from the rat gastric sympathetic nerves
    Kumiko Nakamura
    Department of Pharmacology, School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Eur J Pharmacol 629:111-7. 2010
    Previously, we reported that prostanoid TP receptor mediates the inhibition of electrically evoked noradrenaline release from gastric sympathetic nerves in rats...
  48. doi Glybenclamide: an antidiabetic with in vivo antithrombotic activity
    Harold J Ting
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, 309 E Second Street, Pomona, CA 91766, USA
    Eur J Pharmacol 649:249-54. 2010
    ..Although TXA₂ acts by binding to a seven-transmembrane receptor (i.e., the prostanoid TP receptor) that participates in the genesis of thrombosis, currently, there are no antagonists available for ..
  49. doi TNF-alpha induces thromboxane receptor signaling-dependent microcirculatory dysfunction in mouse liver
    Hiroyuki Katagiri
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Shock 30:463-7. 2008
    ..Blockade of TNF-alpha generation and TP receptor signaling may be a good strategy for managing endotoxin-induced hepatic injury...
  50. doi Prostaglandin D(2) induces contraction via thromboxane A(2) receptor in rat liver myofibroblasts
    Tomoharu Maruyama
    Department of Veterinary Pharmacology, Agriculture and Life Science, The University of Tokyo, Japan
    Eur J Pharmacol 591:237-42. 2008
    ..chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) and thromboxane A(2) receptor (prostanoid TP receptor), were expressed in liver MFs...
  51. doi Centrally administered neuromedin U elevates plasma adrenaline by brain prostanoid TP receptor-mediated mechanisms in rats
    Tsuyoshi Sasaki
    Department of Pharmacology, School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Eur J Pharmacol 592:81-6. 2008
    ..These results suggest that centrally administered neuromedin U evokes the secretion of adrenaline from the adrenal medulla by brain prostanoid TP receptor-mediated mechanisms in rats.
  52. pmc Expression of thromboxane synthase and the thromboxane-prostanoid receptor in the mouse and rat retina
    William S Wright
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Exp Eye Res 89:532-7. 2009
    ....
  53. doi Chronic inhibition of nitric-oxide synthase potentiates endothelium-dependent contractions in the rat aorta by augmenting the expression of cyclooxygenase-2
    Chen Qu
    Department of Pharmacology and Pharmacy, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    J Pharmacol Exp Ther 334:373-80. 2010
    ..These experiments demonstrate that chronic NOS inhibition increases endothelium-dependent contractions of the rat aorta by inducing COX-2 expression and augmenting the production of EDCF...
  54. doi Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway
    Luzheng Xue
    Oxagen Ltd, Abingdon, United Kingdom
    J Immunol 182:7580-6. 2009
    ..These data suggest that in addition to promoting the recruitment and activation of Th2 cells, PGD(2) may also impede the resolution of allergic inflammation through inhibiting apoptosis of Th2 cells...
  55. ncbi Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites
    Susan Lorey
    Department of Biochemistry Biotechnology, Institute of Biochemistry, Martin Luther University Halle Wittenberg, Halle, Germany
    Eur J Biochem 270:2147-56. 2003
    ..Recently, we characterized the thromboxane A2 receptor peptide TXA2-R(1-9), bearing the N-terminal MWP sequence motif, as a potent DP IV inhibitor possibly ..
  56. pmc The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C
    S Hamid-Bloomfield
    Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent
    Br J Pharmacol 100:761-6. 1990
    ..8. These findings indicate that the bronchoconstrictor effect of inhaled PGD2 in guinea-pigs in vivo is mediated primarily through direct TP-receptor activation and not through actions on DP-receptors...
  57. ncbi Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3
    M Taketo
    Banyu Tsukuba Research Institute Merck, Tsukuba, Japan
    Genomics 19:585-8. 1994
    ..None of the three loci cosegregated with each other. Tbxa2r mapped to Chr 10, Ptgerep2 mapped to the distal end of Chr 3. Possible human loci for these receptors are predicted based on the homology between mouse and human chromosomes...
  58. ncbi [Cyclooxygenase 2 and carcinogenesis]
    Sylvie Rodrigues
    INSERM U482, Signalisation et fonctions cellulaires applications au diabète et aux cancers digestifs, Hopital Saint Antoine, 75571 Paris Cedex
    Bull Cancer 91:S61-76. 2004
    ..These mechanisms establish the rationale behind the therapeutic targeting of Cox2 in human solid tumors...
  59. ncbi Down-regulation of T cell activation following inhibition of dipeptidyl peptidase IV/CD26 by the N-terminal part of the thromboxane A2 receptor
    S Wrenger
    Institute of Experimental Internal Medicine, Department of Internal Medicine, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Biol Chem 275:22180-6. 2000
    ..Data base searches revealed the thromboxane A2 receptor (TXA2-R) as a membrane protein extracellularly exposing N-terminal MWP...
  60. doi Replication of genetic association studies in asthma and related phenotypes
    Siizkhuu Undarmaa
    Department of Public Health, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hum Genet 55:342-9. 2010
    ..Stratification of the subjects by environmental factors or other confounding factors may be necessary to improve the sensitivity and reliability of association results...
  61. ncbi Benextramine acts as an irreversible noncompetitive antagonist of U46619-mediated contraction of the rat small mesenteric artery
    P H van der Graaf
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Netherlands
    Eur J Pharmacol 300:211-4. 1996
    ..The selective prostanoid TP receptor antagonist, SQ 30,741 ([1S-[1 alpha,2 alpha(5Z),3 alpha,4 alpha]]-7- [[[[[(oxaheptyl)amino]acetyl]amino]-..
  62. ncbi G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Department of Medical Genetics and Microbiology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Diagn Ther 10:353-66. 2006
    ..cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2), and prostaglandin D2 receptors (PTGDR and CRTH2), thromboxane A2 receptor (TBXA2R), beta2-adrenergic receptor (ADRB2), chemokine receptor 5 (CCR5), and the G protein-coupled ..
  63. ncbi Potentiation of adrenaline vasoconstrictor response by sub-threshold concentrations of U-46619 in human umbilical vein: involvement of smooth muscle prostanoid TP(alpha) receptor isoform
    Andrea Emilse Errasti
    Departamento de Farmacologia, Universidad de Buenos Aires, Paraguay 2155, Piso 9, 1121, Ciudad Autonoma de Buenos Aires, Argentina
    Eur J Pharmacol 562:227-35. 2007
    ..of proteins with an electrophoretic mobility (47- and 55-kDa) indistinguishable from human platelet prostanoid TP receptor, a rich source of prostanoid TP(alpha) receptor isoform...
  64. doi What do we know about the genetics of aspirin intolerance?
    N S Palikhe
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    J Clin Pharm Ther 33:465-72. 2008
    ..Analyses of the genetic backgrounds of patients with AIA and AIU will promote the development of early diagnostic and therapeutic interventions, which may reduce the incidence of AIA and AIU...
  65. pmc Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle
    Rob D Catalano
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 17:182-92. 2011
    ..The expression profiles described have the potential to identify specific prostanoid components that may be dysregulated in inflammatory-associated disorders of the endometrium...
  66. ncbi Evidence for the involvement of the cyclooxygenase-metabolic pathway in diclofenac-induced inhibition of spontaneous contraction of rat portal vein smooth muscle cells
    Keiichi Shimamura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
    J Smooth Muscle Res 41:195-206. 2005
    ..On the other hand, neither ozagrel, a thromboxane synthase inhibitor, nor SQ29548, a prostanoid TP receptor antagonist, significantly affected spontaneous contractions...
  67. doi Thromboxane-prostanoid receptor expression and antagonism in dextran-sodium sulfate-induced colitis
    Patsy R Carter
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Inflamm Res 60:87-92. 2011
    ..In the current study of murine colitis, the potential roles of thromboxane and the thromboxane-prostanoid (TP) receptor were investigated, in as much as thromboxane signaling has been implicated in human inflammatory bowel disease...
  68. ncbi GIPC gene family (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 9:585-9. 2002
    ..1-p22.3 region; GIPC3 gene to thromboxane A2 receptor (TBXA2R) gene in human chromosome 19p13.3 region...
  69. doi Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in the thromboxane A2 receptor
    T Kamae
    Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Thromb Haemost 9:1040-8. 2011
    ..Thromboxane A(2) receptor (TXA(2)R) abnormality appears to dominantly disturb platelet function...
  70. doi 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins
    Susana Jerez
    Laboratorio de Fisiología y Farmacología Vascular, Departamento de Bioingeniería, Instituto Superior de Investigaciones Biológicas UNT CONICET, Universidad Nacional de Tucuman, Tucuman, Argentina
    Prostaglandins Other Lipid Mediat 97:36-42. 2012
    ..The endothelium-independent mechanism of 17-ODYA-effect may involve increase of vasoconstrictor cyclooxygenase-metabolites induced by prostaglandin-ω-hydroxylase-inhibition...
  71. pmc Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease
    James H Soper
    Center for Neurodegenerative Disease Research, Institute on Aging, Perlman School of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, Pennsylvania, 19104 6323
    ACS Chem Neurosci 3:928-40. 2012
    ..Compounds of this type hold promise as potential lead structures to develop drug candidates for the treatment of AD...
  72. pmc Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation
    Valerie Capra
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 8:e60475. 2013
    ..Evolutionary forces may have favored regulation mechanisms leading to low basal activity and selected against more highly active phenotypes...
  73. pmc Thromboxane receptor hyper-responsiveness in hypoxic pulmonary hypertension requires serine 324
    K T Santhosh
    Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, MB, Canada
    Br J Pharmacol 171:676-87. 2014
    ..Hence, we examined the role of PKA-accessible serine residues in determining TP receptor affinity, using site-directed mutational analysis...
  74. ncbi Prenatal exposure to hyperoxia modifies the thromboxane prostanoid receptor-mediated response to H2O2 in the ductus arteriosus of the chicken embryo
    S van der Sterren
    Department of Pediatrics, Maastricht University Medical Center MUMC, School for Oncology and Developmental Biology GROW, Maastricht, The Netherlands
    J Physiol Pharmacol 65:283-93. 2014
    ..Under normal conditions H2O2-induced contraction prevails and relaxation is unmasked after pharmacological or functional (i.e.hyperoxia) TP receptor impairment. ..
  75. doi Des-Arg9-bradykinin causes kinin B1 receptor mediated endothelium-independent contractions in endotoxin-treated porcine coronary arteries
    Amar S More
    WCU Program, Department of BIN Fusion technology, Chonbuk National University, Chonju, Republic of Korea
    Pharmacol Res 90:18-24. 2014
    ..Accordingly, kinin B1 receptor induction during inflammation may have a pathological significance in the vasculature, particular in coronary arteries with dysfunctional endothelial cells. ..
  76. ncbi Thromboxane A2 receptor polymorphism in association with cerebral infarction and its regulation on platelet function
    Jiaxiang Shao
    Room 211, Med X Building, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, China
    Curr Neurovasc Res 12:15-24. 2015
    ..Together these data show that TXA2R polymorphisms may affect platelet function and the risk of developing cerebral ischemia...
  77. doi Maternal fructose-intake-induced renal programming in adult male offspring
    You Lin Tain
    Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taiwan Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan
    J Nutr Biochem 26:642-50. 2015
    ..Moreover, our results highlight genes and pathways involved in renal programming as potential targets for therapeutic approaches to prevent metabolic-syndrome-related comorbidities in children with HF exposure in early life. ..
  78. doi Association between thromboxane A2 receptor polymorphisms and asthma risk: A meta-analysis
    Yilin Pan
    a Department of Respiratory Medicine, The First Affiliated Hospital of Xi an Jiaotong University, Xi an, Shaanxi, China
    J Asthma 53:576-82. 2016
    To determine whether there is an association between thromboxane A2 receptor (TBXA2R) gene polymorphisms (+924C/T and +795C/T) and asthma risk by conducting a meta-analysis.
  79. ncbi Association of thromboxane A2 receptor (TBXA2R) with atopy and asthma
    Hyoung Doo Shin
    J Allergy Clin Immunol 112:454-7. 2003
  80. ncbi Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew)
    Kelvin K W Kan
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    Eur J Pharmacol 482:297-304. 2003
    The emetic action of the prostanoid TP receptor agonist, 11alpha,9alpha-epoxymethano-15S-hydroxyprosta-5Z,13E-dienoic acid (U46619; 300 microg/kg, i.p.), was investigated in Suncus murinus...
  81. ncbi Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) on human umbilical vein
    Federico M Daray
    Departamento de Farmacologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 9, 1121, Buenos Aires, Argentina
    Eur J Pharmacol 499:189-95. 2004
    ..10+/-0.04). However, both isoprostanes were equieffective. The prostanoid TP receptor antagonists, ICI-192,605 (4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid) ..
  82. doi Effects of the dual TP receptor antagonist and thromboxane synthase inhibitor EV-077 on human endothelial and vascular smooth muscle cells
    Marcelo H Petri
    Department of Medicine, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Biochem Biophys Res Commun 441:393-8. 2013
    ....
  83. doi Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi
    Yacine Tabet
    Le Bilarium, Department of Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 304:L562-9. 2013
    ..Because of its potent anti-inflammatory and relaxing properties, epoxyeicosanoid signaling may represent a promising target in asthma and chronic obstructive pulmonary disease...
  84. pmc Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction
    Matthias R Meyer
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Hypertension 59:507-12. 2012
    ..These findings may be important for understanding and treating diseases associated with increased endothelial vasoconstrictor prostanoid activity such as hypertension and obesity...
  85. ncbi Chromosomal localization of the human prostanoid receptor gene family
    A M Duncan
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Genomics 25:740-2. 1995
    ..1, 19p13.3, and 19q13.3, respectively. The PTGFR and PTGER3 genes mapped to chromosome 1 at positions 1p31.1 and 1p31.2, respectively, and PTGER2 gene mapped to chromosome band 5p13.1...
  86. ncbi Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells
    D D D'Angelo
    Department of Internal Medicine, University of Cincinnati, Ohio
    J Pharmacol Exp Ther 271:1034-41. 1994
    ..63 +/- 0.18 nM and KdL of 12.5 +/- 5.0 nM, with Bmaxs of 29 +/- 9 and 212 +/- 41 fmol/mg of protein, respectively (n = 7)].(ABSTRACT TRUNCATED AT 250 WORDS)..
  87. ncbi Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414
    T Kurokawa
    DDS Research Laboratories, Takeda Chemical Industries, Ltd, Osaka, Japan
    Biol Pharm Bull 17:383-5. 1994
    The human thromboxane A2 receptor (TXA2-R)-coding gene was introduced into Chinese hamster ovary cells and a cell line (TCHO-25) stably expressing TXA2-R, at a level of 3 x 10(5)/cell, was obtained...
  88. ncbi Characterization of the prostanoid TP receptor population in human nonpregnant myometrium
    M Senchyna
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Pharmacol Exp Ther 279:262-70. 1996
    We have used both functional and binding studies to fully characterize the prostanoid TP receptor in the myometrium from nonpregnant human donors...
  89. ncbi Excitatory and inhibitory actions of isoprostanes in human and canine airway smooth muscle
    L J Janssen
    Asthma Research Group, Father Sean O Sullivan Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Pharmacol Exp Ther 295:506-11. 2000
    ..0, 5.9, and 6.2 microM, respectively). These contractions were sensitive to the prostanoid TP receptor antagonist ICI 192,605 (0...
  90. ncbi Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50)
    Moulay Driss Rochdi
    Service de Rhumatologie, Faculté de Médecine and Centre de Recherche Clinique CHUS, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 277:40751-9. 2002
    ..This study constitutes the first demonstration of an interaction between a G protein alpha subunit and another protein through a PDZ domain, with broad implications in the regulation of diverse physiological systems...
  91. ncbi The central role of thromboxane and platelet activating factor receptors in ex vivo regulation of endotoxin-induced monocyte tissue factor activity in human whole blood
    Karl Erik Eilertsen
    Department of Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    J Endotoxin Res 8:285-93. 2002
    ....
  92. ncbi Solution structure of the third extracellular loop of human thromboxane A2 receptor
    Jiaxin Wu
    Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas Health Science Center, 6431 Fannin St, Houston, TX 77030, USA
    Arch Biochem Biophys 414:287-93. 2003
    The extracellular domains of the thromboxane A2 receptor (TP receptor) were found to be involved in the specific ligand recognition...
  93. ncbi Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:30725-31. 2003
    ..Thus, our data indicate that PI3K, together with the integrin outside-in signaling, play a central role in inducing the second wave of platelet secretion, which leads to the second wave of irreversible platelet aggregation...
  94. ncbi Proinflammatory actions of thromboxane receptors to enhance cellular immune responses
    Dennis W Thomas
    Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Immunol 171:6389-95. 2003
    ..Specific inhibition of the TP receptor may provide a more precise approach to limit inflammation without some of the untoward effects associated with NSAIDs...
  95. ncbi TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death
    I Shing Yu
    Graduate Institute of Medical Technology, Department of Pathology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
    Blood 104:135-42. 2004
    ..The TXAS-deleted mice will be valuable for investigating the roles of arachidonate metabolic shunt in various pathophysiologic processes...
  96. ncbi Platelet receptors for adenine nucleotides and thromboxane A2
    Swaminathan Murugappan
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Semin Thromb Hemost 30:411-8. 2004
    ..This review focuses on the contribution of different nucleotide receptors and TP receptors to platelet function and their potential as antithrombotic agents...
  97. ncbi Molecular profiling of inflammatory breast cancer: identification of a poor-prognosis gene expression signature
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Clin Cancer Res 10:6789-95. 2004
    ..Inflammatory breast cancer (IBC) is a rare but particularly aggressive form of primary breast cancer. The molecular mechanisms responsible for IBC are largely unknown...
  98. ncbi Real-time monitoring of receptor and G-protein interactions in living cells
    Céline Gales
    Department of Biochemistry, Universite de Montreal, P O Box 6128 Down town station, Montreal, H3C 3J7, Canada
    Nat Methods 2:177-84. 2005
    ....
  99. ncbi Brain prostanoid TP receptor-mediated adrenal noradrenaline secretion and EP3 receptor-mediated sympathetic noradrenaline release in rats
    Keiko Yokotani
    Department of Neuropharmacology, Program of Neural Integration, Graduate School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Eur J Pharmacol 512:29-35. 2005
    ..Brain prostanoid TP receptors activated by bombesin are also involved in the adrenal adrenaline secretion...
  100. ncbi Coupling interaction between thromboxane A2 receptor and alpha-13 subunit of guanine nucleotide-binding protein
    Kuo Chen Chou
    Gordon Life Science Institute, 13784 Torrey Del Mar, San Diego, CA 92130, USA
    J Proteome Res 4:1681-6. 2005
    ..The findings may also provide useful insights for stimulating new therapeutic approaches by manipulating the interaction of the receptor with the relevant G proteins...
  101. pmc Palmitoylation of the TPbeta isoform of the human thromboxane A2 receptor. Modulation of G protein: effector coupling and modes of receptor internalization
    Helen M Reid
    School of Biomolecular and Biomedical Sciences, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Cell Signal 19:1056-70. 2007
    ....

Research Grants8

  1. Joshua A Boyce; Fiscal Year: 2016
    ..The studies proposed will reveal potential causative mechanisms in AERD and identify therapeutic targets that could restore normal homeostasis. ..
  2. Thrombin signaling in Hemostatis and thrombosis
    Shaun R Coughlin; Fiscal Year: 2010
    ..These studies will illuminate how key effectors of hemostasis and thrombosis interact. ..
  3. STRUCTURE & FUNCTION RELATIONSHIP: PROSTANOID RECEPTORS
    Ke He Ruan; Fiscal Year: 2008
    ..Determine the solution conformation of segments comprising the intracellular domains. ..
  4. Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthase
    Ke He Ruan; Fiscal Year: 2009
    ....
  5. Pregnane X Receptor as a Regulator of Multi-Drug Resistance in Prostate Cancer
    Daotai Nie; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. CALCIUM AND ENDOCYTOTIC MEMBRANE RETRIEVAL
    Nevin Lambert; Fiscal Year: 2003
    ..Specifically we will determine how exocytotic activity influences membrane depolarization and the cellular distribution of P-type calcium channels. ..
  7. Regulation of G-protein signaling in CNS neurons
    Nevin Lambert; Fiscal Year: 2006
    ..If our hypothesis is correct, we will identify presynaptic terminals as key sites for the adaptive changes responsible for the development of drug effects, drug tolerance and drug dependence. ..
  8. NEVIN ALAN LAMBERT; Fiscal Year: 2016
    ..g. when and where receptors, G-proteins and effector molecules interact with each other to transmit signals. The goal of this project is to provide this information. ..