thrombospondin 1

Summary

Gene Symbol: thrombospondin 1
Description: thrombospondin 1
Alias: THBS, THBS-1, TSP, TSP-1, TSP1, thrombospondin-1, thrombospondin-1p180, thrombospondin-p50
Species: human
Products:     thrombospondin 1

Top Publications

  1. Roberts D. Regulation of tumor growth and metastasis by thrombospondin-1. FASEB J. 1996;10:1183-91 pubmed
    Thrombospondin-1 (TSP1) is an extracellular matrix glycoprotein that influences cell adhesion, motility, and growth...
  2. Yamauchi Y, Kuroki M, Imakiire T, Abe H, Uchida H, Beppu R, et al. Thrombospondin-1 differentially regulates release of IL-6 and IL-10 by human monocytic cell line U937. Biochem Biophys Res Commun. 2002;290:1551-7 pubmed
    We investigated possible regulatory effects of thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, on cytokine release from macrophages...
  3. Oue N, Matsumura S, Nakayama H, Kitadai Y, Taniyama K, Matsusaki K, et al. Reduced expression of the TSP1 gene and its association with promoter hypermethylation in gastric carcinoma. Oncology. 2003;64:423-9 pubmed
    Thrombospondin-1 (TSP1) is a potent peptide shown in some tumor systems to be linked with angiogenesis. Epigenetic alteration of TSP1 has been reported in various primary tumors...
  4. Wahab N, Schaefer L, Weston B, Yiannikouris O, Wright A, Babelova A, et al. Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli. Diabetologia. 2005;48:2650-60 pubmed
    We quantified the glomerular expression of thrombospondin-1 (THBS1, also known as TSP-1), transforming growth factor beta 1 (TGFB1, also known as TGF-beta1) and connective tissue growth factor (CTGF) at each stage of diabetic nephropathy...
  5. Annis D, Gunderson K, Mosher D. Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations. J Biol Chem. 2007;282:27067-75 pubmed
    ..The eight C-type and five N-type calcium-binding repeats of TSP-2 form a circuitous wire that, in 2 mm calcium, interacts at its ends with more N-terminal epidermal growth factor (..
  6. Maloney S, Sullivan D, Suchting S, Herbert J, Rabai E, Nagy Z, et al. Induction of thrombospondin-1 partially mediates the anti-angiogenic activity of dexrazoxane. Br J Cancer. 2009;101:957-66 pubmed publisher
    ..of microvascular endothelial cells in vitro with subtoxic doses of dexrazoxane stimulated thrombospondin-1 (THBS-1) secretion...
  7. Rico M, Manns J, Driban J, Uknis A, Kunapuli S, DeLa Cadena R. Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis. Transl Res. 2008;152:95-8 pubmed publisher
    Thrombospondin-1 (TSP1/THBS1) plays a major role in the pathophysiology of rheumatoid arthritis (RA); however, its interface with the cytokine network involved in RA has not been delineated...
  8. Calzada M, Kuznetsova S, Sipes J, Rodrigues R, Cashel J, Annis D, et al. Calcium indirectly regulates immunochemical reactivity and functional activities of the N-domain of thrombospondin-1. Matrix Biol. 2008;27:339-51 pubmed publisher
    ..These results indicate connectivity between calcium binding sites in the C-terminal signature domain and the N-modules of thrombospondin-1 that regulates ligand binding and functional activities of the N-modules. ..
  9. Gao A, Lindberg F, Finn M, Blystone S, Brown E, Frazier W. Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J Biol Chem. 1996;271:21-4 pubmed
    ..These data establish IAP (CD47) as a receptor for the CBD of TS1 and suggest a mechanism for the well established effects of the CBD on cell motility. ..

More Information

Publications81

  1. Narizhneva N, Razorenova O, Podrez E, Chen J, Chandrasekharan U, DiCorleto P, et al. Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium. FASEB J. 2005;19:1158-60 pubmed
    ..not only promotes thrombosis but also early stages of atherogenesis, we considered the role of thrombospondin-1 (TSP-1), a matricellular protein released in abundance from activated platelets and accumulated in sites of vascular ..
  2. Bhattacharyya S, Marinic T, Krukovets I, Hoppe G, Stenina O. Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose. J Biol Chem. 2008;283:5699-707 pubmed
    ..Thrombospondin-1 (TSP-1), a potent antiangiogenic and proatherogenic protein, has been implicated in the development of several vascular ..
  3. Urquidi V, Sloan D, Kawai K, Agarwal D, Woodman A, Tarin D, et al. Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis. Clin Cancer Res. 2002;8:61-74 pubmed
    ..Manipulation of candidate genes in these cells will permit evaluation of their functional significance in the geometric progression of breast cancer. ..
  4. Liu Y, Annis D, Mosher D. Interactions among the epidermal growth factor-like modules of thrombospondin-1. J Biol Chem. 2009;284:22206-12 pubmed publisher
    ..Thrombospondin-1 (TSP-1) is a multimodular glycoprotein with three EGF-like modules, E1, E2, and E3, arranged in tandem...
  5. Harada H, Nakagawa K, Saito M, Kohno S, Nagato S, Furukawa K, et al. Introduction of wild-type p53 enhances thrombospondin-1 expression in human glioma cells. Cancer Lett. 2003;191:109-19 pubmed
    ..These studies may suggest that mutation of p53 gene endows gliomas with an angiogenic phenotype by reducing thrombospondin-1 production as well as enhancing the angiogenesis inducers in the early phase of malignant progression. ..
  6. Rodrigues R, Guo N, Zhou L, Sipes J, Williams S, Templeton N, et al. Conformational regulation of the fibronectin binding and alpha 3beta 1 integrin-mediated adhesive activities of thrombospondin-1. J Biol Chem. 2001;276:27913-22 pubmed
    ..We now demonstrate that conformational regulation of the matrix glycoprotein thrombospondin-1 (TSP1) can also modulate its binding to an integrin receptor...
  7. Presser L, Haskett A, Waris G. Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-?1: role of TGF-?1 in HCV replication. Virology. 2011;412:284-96 pubmed publisher
    ..Using siRNA approach we demonstrated that HCV-induced furin and thrombospondin-1 (TSP-1) are involved in the proteolytic activation of TGF-?1...
  8. Lawler J, Hynes R. The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol. 1986;103:1635-48 pubmed
    ..This sequence is probably the site for the association of thrombospondin with cells. In addition, localized homologies with procollagen, fibronectin, and von Willebrand factor are present in one region of the thrombospondin molecule. ..
  9. Veliceasa D, Ivanovic M, Hoepfner F, Thumbikat P, Volpert O, Smith N. Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma. FEBS J. 2007;274:6365-77 pubmed
    ..To evaluate the role of an angiogenesis inhibitor, thrombopsondin-1 (TSP1), we compared TSP1 production in human RCC and normal tissue and secretion by the normal renal epithelium (human ..
  10. Huwiler K, Vestling M, Annis D, Mosher D. Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1. Biochemistry. 2002;41:14329-39 pubmed
    Thrombospondin-1 (TSP1), a modular secreted glycoprotein, possesses anti-angiogenic activity both in vitro and in vivo. This activity has been localized to the thrombospondin type 1 repeats/domains (TSR)...
  11. Sarfati M, Fortin G, Raymond M, Susin S. CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling. Curr Drug Targets. 2008;9:842-50 pubmed
    ..CD47 and its two ligands, i.e. thrombospondin 1 (TSP-1) and SIRP-alpha, were identified as a previously unappreciated inhibitory axis of DC and T cell ..
  12. Rusnati M, Taraboletti G, Urbinati C, Tulipano G, Giuliani R, Molinari Tosatti M, et al. Thrombospondin-1/HIV-1 tat protein interaction: modulation of the biological activity of extracellular Tat. FASEB J. 2000;14:1917-30 pubmed
    ..Here we demonstrate that human thrombospondin-1 (TSP), a plasma glycoprotein and constituent of the extracellular matrix, binds to glutathione-S-transferase (GST)-Tat ..
  13. Adams J. Thrombospondin-1. Int J Biochem Cell Biol. 1997;29:861-5 pubmed
    ..The molecular mechanisms underlying these activities are beginning to be examined. Medical interest in thrombospondin-1 centres on its roles in haemostasis and its effects on angiogenesis. ..
  14. Esemuede N, Lee T, Pierre Paul D, Sumpio B, Gahtan V. The role of thrombospondin-1 in human disease. J Surg Res. 2004;122:135-42 pubmed
    Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein secreted by many cell types. It is a component of the extracellular matrix during active and subacute processes...
  15. Dameron K, Volpert O, Tainsky M, Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science. 1994;265:1582-4 pubmed
    ..wild-type allele of the p53 tumor suppressor gene and to be the result of reduced expression of thrombospondin-1 (TSP-1), a potent inhibitor of angiogenesis...
  16. Ridnour L, Isenberg J, Espey M, Thomas D, Roberts D, Wink D. Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc Natl Acad Sci U S A. 2005;102:13147-52 pubmed
    ..An additional protein involved in the regulation of angiogenesis is thrombospondin-1 (TSP1), a matricellular glycoprotein known to influence adhesion, migration, and proliferation of endothelial cells...
  17. McGray A, Gingerich T, Petrik J, LaMarre J. Regulation of thrombospondin-1 expression through AU-rich elements in the 3'UTR of the mRNA. Cell Mol Biol Lett. 2011;16:55-68 pubmed publisher
    Thrombospondin-1 (TSP-1) is a matricellular protein that participates in numerous normal and pathological tissue processes and is rapidly modulated by different stimuli...
  18. Vallejo A, Yang H, Klimiuk P, Weyand C, Goronzy J. Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction. J Immunol. 2003;171:1732-40 pubmed
    ..T cell costimulation through CD47 is attributed to specific interaction with thrombospondin-1 (TSP1), a CD47 ligand displayed on FLS...
  19. Osada Oka M, Ikeda T, Akiba S, Sato T. Hypoxia stimulates the autocrine regulation of migration of vascular smooth muscle cells via HIF-1alpha-dependent expression of thrombospondin-1. J Cell Biochem. 2008;104:1918-26 pubmed publisher
    ..of human coronary artery smooth muscle cells (CASMCs) via HIF-1alpha-dependent expression of thrombospondin-1 (TSP-1)...
  20. Margosio B, Marchetti D, Vergani V, Giavazzi R, Rusnati M, Presta M, et al. Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2. Blood. 2003;102:4399-406 pubmed
    The antiangiogenic factor thrombospondin 1 (TSP-1) binds with high affinity to several heparin-binding angiogenic factors, including fibroblast growth factor 2 (FGF-2), vascular endothelial growth factor (VEGF), and hepatocyte growth ..
  21. Salajegheh M, Raju R, Schmidt J, Dalakas M. Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis. J Neuroimmunol. 2007;187:166-74 pubmed
    The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to beta-amyloid, both relevant to IBM...
  22. Margosio B, Rusnati M, Bonezzi K, Cordes B, Annis D, Urbinati C, et al. Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain. Int J Biochem Cell Biol. 2008;40:700-9 pubmed
    ..The finding that this domain is active in inhibiting angiogenesis indicates that the type III repeats represent a novel antiangiogenic domain of thrombospondin-1. ..
  23. Papadaki C, Mavroudis D, Trypaki M, Koutsopoulos A, Stathopoulos E, Hatzidaki D, et al. Tumoral expression of TXR1 and TSP1 predicts overall survival of patients with lung adenocarcinoma treated with first-line docetaxel-gemcitabine regimen. Clin Cancer Res. 2009;15:3827-33 pubmed publisher
    In vitro data suggest that down-regulation of thrombospondin 1 (TSP1) expression from TXR1 is associated with resistance to taxane-based chemotherapy...
  24. Kaur S, Martin Manso G, Pendrak M, Garfield S, Isenberg J, Roberts D. Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47. J Biol Chem. 2010;285:38923-32 pubmed publisher
    Thrombospondin-1 (TSP1) can inhibit angiogenic responses directly by interacting with VEGF and indirectly by engaging several endothelial cell TSP1 receptors...
  25. Ioachim E, Michael M, Salmas M, Damala K, Tsanou E, Michael M, et al. Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components. BMC Cancer. 2006;6:140 pubmed
    Thrombospondin-1 (TSP-1) is an extracellular matrix component glycoprotein, which is known to be a potent inhibitor of angiogenesis and may be important in cancer invasiveness...
  26. Narizhneva N, Byers Ward V, Quinn M, Zidar F, Plow E, Topol E, et al. Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction. J Biol Chem. 2004;279:21651-7 pubmed
    ..These data suggest a potential molecular and cellular basis for a genetic risk factor associated with early onset myocardial infarction. ..
  27. Lindner D, Wu Y, Haney R, Jacobs B, Fruehauf J, Tuthill R, et al. Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis. Matrix Biol. 2013;32:123-32 pubmed publisher
    ..result in functional inhibition of angiogenesis, we undertook in vitro and in vivo studies of thrombospondin-1 (TSP1), a known inhibitor of angiogenesis...
  28. Kukreja A, Radfar S, Sun B, Insogna K, Dhodapkar M. Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease. Blood. 2009;114:3413-21 pubmed publisher
    ..Osteoclastogenesis is cell contact dependent, leading to up-regulation of thrombospondin-1 (TSP-1) in DCs...
  29. Kang J, Kim M, Chang S, Sim S, Kim M, Jo Y. CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A. J Cell Biochem. 2008;104:1192-203 pubmed publisher
    ..Thrombospondin-1 (TSP1) has been recognized as a potent inhibitor of angiogenesis...
  30. Hannah B, Misenheimer T, Pranghofer M, Mosher D. A polymorphism in thrombospondin-1 associated with familial premature coronary artery disease alters Ca2+ binding. J Biol Chem. 2004;279:51915-22 pubmed
    ..Thus, the Ser-700 polymorphism alters a rapidly filled, high affinity Ca2+ -binding site in the first Ca2+ -binding motif. Slower Ca2+ binding to adjoining motifs partly compensates for the change. ..
  31. Rodriguez Manzaneque J, Lane T, Ortega M, Hynes R, Lawler J, Iruela Arispe M. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci U S A. 2001;98:12485-90 pubmed
    ..To ascertain the participation of the endogenous angiogenic inhibitor thrombospondin-1 (TSP1) in tumor progression, we generated mammary tumor-prone mice that either lack, or specifically overexpress, TSP1 in ..
  32. Guerrero D, Guarch R, Ojer A, Casas J, Ropero S, Mancha A, et al. Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma. BJU Int. 2008;102:747-55 pubmed publisher
    ..of human papillomavirus (HPV) infection, the methylation status in the promoter region of thrombospondin-1 (TSP-1), RAS association domain family 1A (RASSF1-A) and p16 genes, and the expression of TSP-1, CD31, p16 and p53 ..
  33. Li S, Liu Z, Uzunel M, Sundqvist K. Endogenous thrombospondin-1 is a cell-surface ligand for regulation of integrin-dependent T-lymphocyte adhesion. Blood. 2006;108:3112-20 pubmed
    ..We show here that endogenous thrombospondin-1 (TSP-1) is a cell-surface ligand for cis interaction of surface receptors in T lymphocytes controlled by integrins and ..
  34. Primo L, Ferrandi C, Roca C, Marchio S, di Blasio L, Alessio M, et al. Identification of CD36 molecular features required for its in vitro angiostatic activity. FASEB J. 2005;19:1713-5 pubmed
    Thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, acts directly on endothelial cells (EC) via CD36 to inhibit their migration and morphogenesis induced by basic fibroblast growth factor...
  35. Colombel M, Filleur S, Fournier P, Merle C, Guglielmi J, Courtin A, et al. Androgens repress the expression of the angiogenesis inhibitor thrombospondin-1 in normal and neoplastic prostate. Cancer Res. 2005;65:300-8 pubmed
    In order to understand why the angiogenesis inhibitor thrombospondin-1 (TSP1) is often, although not always, associated with prostatic tumors, we have investigated its relationship with the testosterone and the vasculature on which both ..
  36. Young G, Murphy Ullrich J. The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-beta complex. J Biol Chem. 2004;279:47633-42 pubmed
    ..We previously identified thrombospondin 1 (TSP1) as a physiologic activator of TGF-beta in vitro and in vivo...
  37. Rojas A, Meherem S, Kim Y, Washington M, Willis J, Markowitz S, et al. The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer. 2008;123:14-21 pubmed publisher
    ..Consequently, we assessed whether the aberrant methylation of TSP1, the gene for thrombospondin 1, a regulator of TGF-beta ligand activation, is an epigenetic mechanism for inhibiting the TGF-beta signaling ..
  38. Tan K, Duquette M, Liu J, Dong Y, Zhang R, Joachimiak A, et al. Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. J Cell Biol. 2002;159:373-82 pubmed
    Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which mediate cell attachment, glycosaminoglycan binding, inhibition of angiogenesis, activation of TGFbeta, and inhibition of matrix metalloproteinases...
  39. Potikyan G, Savene R, Gaulden J, France K, Zhou Z, Kleinerman E, et al. EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins. Cancer Res. 2007;67:6675-84 pubmed
    ..These findings suggest that thrombospondins play a biologically significant role in tumor vascularization in Ewing's sarcoma and suggest potential therapeutic strategies for future therapeutic intervention. ..
  40. Yang Q, Liu S, Tian Y, Salwen H, Chlenski A, Weinstein J, et al. Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma. Cancer Res. 2003;63:6299-310 pubmed
    ..Methylation-associated inactivation of the angiogenesis inhibitor thrombospondin-1 (TSP-1) has been observed recently in some adult tumors...
  41. Colombo G, Margosio B, Ragona L, Neves M, Bonifacio S, Annis D, et al. Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds. J Biol Chem. 2010;285:8733-42 pubmed publisher
    Endogenous inhibitors of angiogenesis, such as thrombospondin-1 (TSP-1), are promising sources of therapeutic agents to treat angiogenesis-driven diseases, including cancer...
  42. Isenberg J, Jia Y, Fukuyama J, Switzer C, Wink D, Roberts D. Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. J Biol Chem. 2007;282:15404-15 pubmed
    Although CD36 is generally recognized to be an inhibitory signaling receptor for thrombospondin-1 (TSP1), the molecular mechanism for transduction of this signal remains unclear...
  43. Roberts D, Isenberg J, Ridnour L, Wink D. Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis. Clin Cancer Res. 2007;13:795-8 pubmed
    ..We discuss the implications of the balance between these pathways for applying thrombospondin-1 mimetics and redox modifiers as cancer therapeutics. ..
  44. Dias J, Benslimane Ahmim Z, Egot M, Lokajczyk A, Grelac F, Galy Fauroux I, et al. A motif within the N-terminal domain of TSP-1 specifically promotes the proangiogenic activity of endothelial colony-forming cells. Biochem Pharmacol. 2012;84:1014-23 pubmed publisher
    Thrombospondin-1 (TSP-1) gives rise to fragments that have both pro- and anti-angiogenic effects in vitro and in vivo. The TSP-HepI peptide (2...
  45. Crawford S, Stellmach V, Murphy Ullrich J, Ribeiro S, Lawler J, Hynes R, et al. Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell. 1998;93:1159-70 pubmed
  46. Liu Y, Mosher D. Interactions among stalk modules of thrombospondin-1. J Biol Chem. 2009;284:28563-70 pubmed publisher
    ..These results indicate that the TSR and thrombospondin-type EGF-like stalk modules act as a unit that may relay conformational information between the N-terminal and C-terminal parts of the protein. ..
  47. Calzada M, Annis D, Zeng B, Marcinkiewicz C, Banas B, Lawler J, et al. Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1. J Biol Chem. 2004;279:41734-43 pubmed
    In addition to the three known beta(1) integrin recognition sites in the N-module of thrombospondin-1 (TSP1), we found that beta(1) integrins mediate cell adhesion to the type 1 and type 2 repeats...
  48. Carlson C, Liu Y, Keck J, Mosher D. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem. 2008;283:20069-76 pubmed publisher
    ..A polymorphism that changes a conserved Asn to Ser at residue 700 in the most N-terminal calcium-binding repeat of THBS-1 (repeat 1C) is found in 8-10% of European populations and has been linked to increased risk of premature coronary ..
  49. Krishna S, Golledge J. The role of thrombospondin-1 in cardiovascular health and pathology. Int J Cardiol. 2013;168:692-706 pubmed publisher
    ..Thrombospondin (TSP)-1 is an important extracellular matrix component that influences the function of vascular smooth muscle cells, ..
  50. Li Z, Calzada M, Sipes J, Cashel J, Krutzsch H, Annis D, et al. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. J Cell Biol. 2002;157:509-19 pubmed
    ..We found that these opposing responses arise from interactions of TSP1 with two different T cell receptors...
  51. Krispin A, Bledi Y, Atallah M, Trahtemberg U, Verbovetski I, Nahari E, et al. Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states. Blood. 2006;108:3580-9 pubmed
    ..Thrombospondin-1 (TSP-1) and its cleaved 26-kDa heparin-binding domain (HBD) were identified...
  52. Taraboletti G, Rusnati M, Ragona L, Colombo G. Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors. Oncotarget. 2010;1:662-73 pubmed
    ..is affected by several natural ligands, including the endogenous inhibitor of angiogenesis thrombospondin-1 (TSP-1)...
  53. Miyamoto N, Yamamoto H, Taniguchi H, Miyamoto C, Oki M, Adachi Y, et al. Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability. Cancer Lett. 2007;254:42-53 pubmed
    ..analyzed the expression of vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2), thrombospondin 1 (THBS1), and brain-specific angiogenesis inhibitor 1 (BAI1), and we correlated the results with microvessel ..
  54. Smadja D, d Audigier C, Bieche I, Evrard S, Mauge L, Dias J, et al. Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic properties. Arterioscler Thromb Vasc Biol. 2011;31:551-9 pubmed publisher
    ..did not differ between the groups, whereas we found a linear correlation between PAD disease and thrombospondin (TSP)-1 plasma level...
  55. Martin Manso G, Galli S, Ridnour L, Tsokos M, Wink D, Roberts D. Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Res. 2008;68:7090-9 pubmed publisher
    ..We show that overexpression of TSP1 in melanoma cells increases macrophage recruitment into xenograft tumors grown in nude or beige/nude mice...
  56. Yamauchi M, Imajoh Ohmi S, Shibuya M. Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle. Cancer Sci. 2007;98:1491-7 pubmed
    ..By screening keratinocyte-conditioned medium, we found that thrombospondin-1 (TSP-1) is produced from keratinocytes and suppresses human umbilical vein endothelial cells (HUVEC) growth as well as ..
  57. Floquet N, Dedieu S, Martiny L, Dauchez M, Perahia D. Human thrombospondin's (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: a molecular modeling study. Arch Biochem Biophys. 2008;478:103-9 pubmed publisher
    Thrombospondin-1 (TSP-1) interaction with the membranous receptor CD-47 involves the peptide RFYVVMWK (4N-1) located in its C-terminal domain...
  58. Firlej V, Mathieu J, Gilbert C, Lemonnier L, Nakhlé J, Gallou Kabani C, et al. Thrombospondin-1 triggers cell migration and development of advanced prostate tumors. Cancer Res. 2011;71:7649-58 pubmed publisher
    ..Here, we reevaluated the role of the endogenous antiangiogenic thrombospondin 1 (TSP1) in prostate carcinomas in which angiogenesis is an active process...
  59. Bocci G, Francia G, Man S, Lawler J, Kerbel R. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci U S A. 2003;100:12917-22 pubmed
    ..including microtubule inhibitors and an alkylating agent, caused marked induction of gene and protein expression of TSP-1, a potent and endothelial-specific inhibitor of angiogenesis...
  60. Roszmusz E, Patthy A, Trexler M, Patthy L. Structural characterization of the second TSP1-module of human thrombospondin. Biochem Biophys Res Commun. 2002;296:156-60 pubmed
    ..the structural features of this important module-family, we have expressed the second TSP1-domain of human thrombospondin 1 in Escherichia coli...
  61. Lin X, Chen S, Qi Y, Zhu J, Tang Y, Lin J. Overexpression of thrombospondin-1 in stromal myofibroblasts is associated with tumor growth and nodal metastasis in gastric carcinoma. J Surg Oncol. 2012;106:94-100 pubmed publisher
    The roles of thrombospondin-1 (THBS-1) in tumor growth and metastasis are complicated and its function as a cancer inhibitor or promoter remains controversial...
  62. Godyna S, Liau G, Popa I, Stefansson S, Argraves W. Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1. J Cell Biol. 1995;129:1403-10 pubmed
    Thrombospondin-1 (TSP1) has potent biological effects on vasculature smooth muscle cells (SMCs) and endothelial cells...
  63. Nelius T, Filleur S, Yemelyanov A, Budunova I, Shroff E, Mirochnik Y, et al. Androgen receptor targets NFkappaB and TSP1 to suppress prostate tumor growth in vivo. Int J Cancer. 2007;121:999-1008 pubmed
    ..Thus we for the first time identified combined decrease of NFkappaB and increased TSP1 as molecular events underlying the AR anti-tumor activity in vivo...
  64. Doyen V, Rubio M, Braun D, Nakajima T, Abe J, Saito H, et al. Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation. J Exp Med. 2003;198:1277-83 pubmed
    b>Thrombospondin 1 (TSP) elicits potent antiinflammatory activities in vivo, as evidenced by persistent, multiorgan inflammation in TSP null mice...
  65. Chung J, Gao A, Frazier W. Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. J Biol Chem. 1997;272:14740-6 pubmed
    ..Thus an important function of TS1 in platelets is that of a secreted costimulator of alphaIIbbeta3 whose unique properties result in its localization to the platelet surface and the fibrin clot. ..
  66. Wang Rodriguez J, Urquidi V, Rivard A, Goodison S. Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status. Breast Cancer Res. 2003;5:R136-43 pubmed
    ..The expression of osteopontin (OPN) correlated with the metastatic phenotype, whereas thrombospondin-1 (TSP-1) and tyrosinase-related protein-1 (TYRP-1) correlated with the nonmetastatic phenotype of independent MDA-MB-435 ..
  67. Panetti T, Kudryk B, Mosher D. Interaction of recombinant procollagen and properdin modules of thrombospondin-1 with heparin and fibrinogen/fibrin. J Biol Chem. 1999;274:430-7 pubmed
    Many properties have been assigned to the procollagen and properdin (Type I) modules of thrombospondin-1 (TSP1) based on activities of large proteolytic fragments of TSP1 or peptides containing TSP1-derived sequences...
  68. Calzada M, Sipes J, Krutzsch H, Yurchenco P, Annis D, Mosher D, et al. Recognition of the N-terminal modules of thrombospondin-1 and thrombospondin-2 by alpha6beta1 integrin. J Biol Chem. 2003;278:40679-87 pubmed
  69. Guo W, Dong Z, He M, Guo Y, Guo J, Chen Z, et al. Aberrant methylation of thrombospondin-1 and its association with reduced expression in gastric cardia adenocarcinoma. J Biomed Biotechnol. 2010;2010:721485 pubmed publisher
    Investigate the promoter methylation of the Thrombospondin-1 (TSP1) gene in gastric cardia adenocarcinoma (GCA)...
  70. Kvansakul M, Adams J, Hohenester E. Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats. EMBO J. 2004;23:1223-33 pubmed
    ..The crystal structure of a cell-binding TSP-1 fragment, spanning three T3 repeats and the CTD, reveals a compact assembly...
  71. Taraboletti G, Benelli R, Borsotti P, Rusnati M, Presta M, Giavazzi R, et al. Thrombospondin-1 inhibits Kaposi's sarcoma (KS) cell and HIV-1 Tat-induced angiogenesis and is poorly expressed in KS lesions. J Pathol. 1999;188:76-81 pubmed
    ..The aim of this study was to investigate the expression and mechanism of KS control of thrombospondin-1 (TSP), a physiological inhibitor of angiogenesis...
  72. Hofsteenge J, Huwiler K, Macek B, Hess D, Lawler J, Mosher D, et al. C-mannosylation and O-fucosylation of the thrombospondin type 1 module. J Biol Chem. 2001;276:6485-98 pubmed
    Thrombospondin-1 (TSP-1) is a multidomain protein that has been implicated in cell adhesion, motility, and growth...