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Genomes and Genes
| thrombomodulinSummaryGene Symbol: thrombomodulin Description: thrombomodulin Alias: AHUS6, BDCA3, CD141, THPH12, THRM, CD141 antigen, fetomodulin Species: human Top Publications
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Publications
Human thrombomodulin: complete cDNA sequence and chromosome localization of the geneD Z Wen
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110
Biochemistry 26:4350-7. 1987A human umbilical vein endothelial cell cDNA library in lambda gt11 was screened for expression of thrombomodulin antigens with affinity-purified rabbit polyclonal anti-thrombomodulin immunoglobulin G (IgG) and mouse monoclonal anti-human ..
FcεRI levels and frequencies of peripheral blood dendritic cell populations in allergic rhinitisKristina Lundberg
Department of Immunotechnology, Lund University, Lund, Sweden
Hum Immunol 71:931-3. 2010..In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses...
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigensSarah L Jongbloed
Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
J Exp Med 207:1247-60. 2010..We report the first detailed functional analysis of the human CD141+ DC subset...- Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humansPatrick Autissier
Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
Cytometry A 77:410-9. 2010..cells, CD123+ plasmacytoid DC, and three subsets of CD11c+ myeloid DC expressing either CD16, CD1c (BDCA-1), or CD141 (BDCA-3)... - Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradicationTakeshi Nakajima
Carcinogenesis Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
J Gastroenterol 45:37-44. 2010..We aimed to demonstrate the decrease in methylation levels... - Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cellsLionel Franz Poulin
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
J Exp Med 207:1261-71. 2010..Here, we characterize a population of human DCs that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function... - RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatmentChiu Hung Yeh
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Mol Biol Cell 19:3812-22. 2008..b>Thrombomodulin (TM) is a critical factor to activate protein C in mediating the anticoagulation and anti-inflammation effects... - Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammationMarlies Van de Wouwer
The Center for Transgene Technology and Gene Therapy, University of Leuven and the Flanders Interuniversity Institute for Biotechnology VIB, Belgium
Arterioscler Thromb Vasc Biol 24:1374-83. 2004..Most of these can be traced to the vasculature, where the systems most intimately interact. Thrombomodulin (TM), a cell surface-expressed glycoprotein, predominantly synthesized by vascular endothelial cells, is a .. - Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanismLinda Nocchi
Department of Biochemistry, Biology, and Genetics, Polytechnic University of Marche, Ancona, Italy
J Biol Chem 286:19478-88. 2011Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process... - Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effectMarie Christine Bouton
Unité INSERM U698, CHU Xavier Bichat, Paris, France
Circ Res 100:1174-81. 2007The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation... - Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombinLikui Yang
Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
J Biol Chem 278:37465-70. 2003b>Thrombomodulin (TM), or its epidermal growth factor-like domains 456 (TM456), enhances the catalytic efficiency of thrombin toward both protein C and protein C inhibitor (PCI) by 2-3 orders of magnitude... - Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up studyK Auro
Department of Molecular Medicine, KTL, Helsinki, Finland
Arterioscler Thromb Vasc Biol 26:942-7. 2006b>Thrombomodulin is an anticoagulant expressed during endothelial activation and damage... - Variations in the thrombomodulin and endothelial protein C receptor genes in couples with recurrent miscarriageM Kaare
Folkhalsan Institute of Genetics, University of Helsinki, Finland
Hum Reprod 22:864-8. 2007..Loss of function of two of these genes, thrombomodulin (TM) and endothelial protein C receptor (EPCR), causes embryonic lethality in mice... - Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surfaceC T Esmon
Oklahoma Medical Research Foundation, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
FASEB J 9:946-55. 1995..The pathway is initiated when thrombin binds to the endothelial cell thrombin binding protein, thrombomodulin. The complex exhibits dramatically altered macromolecular specificity... - C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cellsBicheng Nan
Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
Surgery 138:212-22. 2005..The objective of the present study was to determine the effect of CRP on the expression of thrombomodulin (TM) and the endothelial protein C receptor (EPCR) in human endothelial cells. - Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and functionGabriella Kunz
Department of Haematology, Imperial College School of Medicine, London, United Kingdom
Blood 99:3646-53. 2002Sporadic mutations in the thrombomodulin (TM) gene occur in patients with both arterial and venous thrombosis, but the effects of these mutations on expression and function are largely unexplored... - Thrombomodulin Ala455Val polymorphism and risk of coronary heart diseaseK K Wu
Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
Circulation 103:1386-9. 2001b>Thrombomodulin (TM) is expressed on the endothelial surface and plays an important role in vasoprotection... - Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE StudyN Aleksic
Division of Hematology, University of Texas Medical School, Houston, TX 77030, USA
J Thromb Haemost 1:88-94. 2003Plasma thrombomodulin (soluble TM; sTM) is considered to be a marker of endothelial injury, but a recent report indicated that the relationship of sTM with thrombosis is complex... - A common thrombomodulin amino acid dimorphism is associated with myocardial infarctionL Norlund
Department of Laboratory Medicine, University of Lund, University Hospital, Sweden
Thromb Haemost 77:248-51. 1997..b>Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C .. - Expression of calretinin, thrombomodulin, keratin 5, and mesothelin in lung carcinomas of different types: an immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleuraMarkku Miettinen
Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Am J Surg Pathol 27:150-8. 2003Several immunohistochemical markers, among them calretinin, thrombomodulin (CD141), keratin 5, and mesothelin, have been documented or suggested as useful markers for positive identification of mesothelioma and to differentiate it from .. - Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulinRashmi Sood
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226, USA
Blood 112:585-91. 2008Absence of the blood coagulation inhibitor thrombomodulin (Thbd) from trophoblast cells of the mouse placenta causes a fatal arrest of placental morphogenesis... - The thrombomodulin-protein C system is essential for the maintenance of pregnancyBerend Isermann
Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA
Nat Med 9:331-7. 2003Disruption of the mouse gene encoding the blood coagulation inhibitor thrombomodulin (Thbd) leads to embryonic lethality caused by an unknown defect in the placenta... - Vascular density and phenotype around ductal carcinoma in situ (DCIS) of the breastN B Teo
Pathology Department, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
Br J Cancer 86:905-11. 2002..were determined using morphometry and a panel of anti-endothelial antibodies (von Willebrand factor, CD31, CD141 and CD34) and related to the presence of invasive carcinoma and other histological features... - Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndromeTara K Maga
Interdepartmental PhD Program in Genetics, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Hum Mutat 31:E1445-60. 2010..5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD). Since aHUS is rare, mutation rate data in large patient cohorts are scarce... - Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell sourceDorthe Schmidt
Clinic for Cardiovascular Surgery and Department of Surgical Research, University and University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
Circulation 116:I64-70. 2007..A novel concept providing prenatally tissue engineered human autologous heart valves based on routinely obtained fetal amniotic fluid progenitors as single cell source is introduced... - Peritubular capillary loss is ameliorated by ramipril or valsartan treatmentBin Zhang
Department of Nephrology, Guangdong Provincial People s Hospital, Nanfang Medical University, Guangzhou, China
Microcirculation 15:337-48. 2008..To identify the preservation of peritubular capillaries conferred by ramipril or valsartan treatment as an additional mechanism for their renoprotection... - Cryopreserved amniotic fluid-derived cells: a lifelong autologous fetal stem cell source for heart valve tissue engineeringDorthe Schmidt
Clinic for Cardiovascular Surgery, Department of Surgical Research, University, University Hospital, Zurich, Switzerland
J Heart Valve Dis 17:446-55; discussion 455. 2008..In order to expand the versatility of these cells also for adult application, cryopreserved AFDC were investigated as a potential life-long available cell source for heart valve tissue engineering... - Three DNA methylation epigenotypes in human colorectal cancerKoichi Yagi
Genome Science Division, Department of Gastrointestinal Surgery, Research Center for Advanced Science and Technology, Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Clin Cancer Res 16:21-33. 2010..Our aim is to clarify DNA methylation epigenotypes of colorectal cancer more comprehensively... - Surface antigens of human mesangial cells: impact of growth surface or IL-1alphaG Sengoelge
Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Wien, Austria
Tissue Antigens 60:383-95. 2002..58, 90, 106, 146, 147, 166; growth factor receptors: CD105, 140b; apoptosis related: CD95; hemostatis related: CD141, 142; miscellaneous: CD44, 109, 138, 151, 157, 165, and 11 nonclustered antigens) reacted with mesangial cells... - Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivoDawn K Coletta
Division of Diabetes, Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA
Am J Physiol Endocrinol Metab 294:E910-7. 2008..The results of the present study demonstrate that insulin acutely regulates the levels of mRNAs involved in inflammation and transcription and identifies several candidate genes, including HES1 and BHLHB2, for further investigation... - Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defenseY D Dean
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, GB
Eur J Immunol 31:1370-81. 2001Phagocytic complement C1q receptor (C1qRp) and thrombomodulin (TM, CD141), are two key members of a novel family of lectin receptors involved in cell-cell interactions and innate immune host defense... - Microarray analysis of the effect of diesel exhaust particles on in vitro cultured macrophagesGeert R Verheyen
Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, B 2400 Mol, Belgium
Toxicol In Vitro 18:377-91. 2004..Our data indicate the multitude of biological processes potentially influenced by DEP... - Twelve loci from HSA10, HSA11 and HSA20 were comparatively FISH-mapped on river buffalo and sheep chromosomesL Iannuzzi
National Research Council CNR, IABBAM, Laboratory of Animal Cytogenetics, Via Argine 1085, 80147 Naples Ponticelli, Italy
Cytogenet Cell Genet 93:124-6. 2001..Indirect comparisons between physical maps achieved on bovid chromosomes and those reported on HSA10, HSA11 and HSA20 were performed... - An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platformJyh Chiang E Wang
Human Immunology Center, David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol Methods 341:106-16. 2009..analysis of activation status and endocytic ability of three major PBDC subsets (CD1c(+)CD11c(+) "MDC1," CD141(+)CD11c(+) "MDC2," and CD303(+)CD11c(-) "PDC") within a single platform... - VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lungA M Healy
The Pulmonary Center, Boston University School of Medicine, Boston Massachusetts 02118, USA
Dev Dyn 219:341-52. 2000..Platelet endothelial cell adhesion molecule-1 (PECAM/CD31) and thrombomodulin (TM/CD141) immunolocalization demonstrate that vascular development occurs in lung cultures... - Phenotypic differences between red pulp capillary and sinusoidal endothelia help localizing the open splenic circulation in humansBirte Steiniger
Institute of Anatomy and Cell Biology, University of Marburg, Robert Koch Str 8, 35032, Marburg, Germany
Histochem Cell Biol 128:391-8. 2007..Double staining for CD34 and CD141 (thrombomodulin) revealed that capillary endothelia in the cords of the splenic red pulp and at the surface of follicles were .. - [Chiparray-based identification of gene expression in HUVECs treated with low frequency electric fields]D Ulrich
Klinik für Plastische Chirurgie, Hand und Verbrennungschirurgie, Universitatsklinikum Aachen, Germany
Handchir Mikrochir Plast Chir 38:149-55. 2006..In this study, we report on IN VITRO studies performed to characterize gene expression profiles using a DNA-microarray in HUVECs (human umbilical vein endothelial cells) exposed to low frequency electrical current... - Mouse models of thrombosis: thrombomodulinHartmut Weiler
Blood Research Institute, Blood Center of Southeastern Wisconsin, Medical College of Wisconsin, Department of Physiology, 8727 Watertown Plank Road, Milwaukee, WI 53226, USA
Thromb Haemost 92:467-77. 2004This review describes animal models of TM-deficiency that cause thrombosis in mice. Thrombomodulin (TM) is a key component of the protein C anticoagulant pathway by facilitating the activation of protein C by thrombin... - Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumorsJennifer Brady
Brain Inflammation and Immunity Group, Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
J Neuropathol Exp Neurol 63:1274-83. 2004..Its protein domain architecture is homologous to that of CD93 and thrombomodulin (CD141), suggesting a similar function in mediating cell-cell interactions... - Genetic aspects of ischemic stroke: coagulation, homocysteine, and lipoprotein metabolism as potential risk factorsSanja Stankovic
Institute for Medical Biochemistry, University School of Pharmacy and Clinical Center of Serbia, Belgrade, Serbia
Crit Rev Clin Lab Sci 47:72-123. 2010..The data assembled could be very useful for further meta-analysis and for future clinical applications... - Screening of the HLDA9 panel on peripheral blood dendritic cell populationsYitian Ding
Mater Medical Research Institute, Aubigny Place, South Brisbane, Queensland, Australia
Immunol Lett 134:161-6. 2011..The CD11c(+) myeloid DC can be divided into populations by CD1c, CD16 and CD141 expression... - Cytogenetic alignment of the bovine chromosome 13 genome map by fluorescence in-situ hybridization of human chromosome 10 and 20 comparative markersD S Gallagher
Department of Animal Science, Texas A and M University, College Station 77843, USA
Chromosome Res 7:115-9. 1999..These FISH results anchor the BTA13 genome map from bands 14-23, and confirm the presence of a conserved HSA10 homologous synteny group on BTA13 centromeric to a HSA20 homologous segment... - Assessment of physiological amplitude, duration, and magnitude of ECG T-wave alternansLaura Burattini
Department of Biomedical, Electronics, and Telecommunication Engineering, Polytechnic University of Marche, 60131 Ancona, Italy
Ann Noninvasive Electrocardiol 14:366-74. 2009.... - Expression of blood dendritic cell antigens (BDCAs) by CD1a+ human pulmonary cellsMaria Tsoumakidou
Lung Pathology Unit, London SW3 6LY, UK
Respir Med 103:935-8. 2009..We investigated the expression of these antigens by isolated human pulmonary CD1a(+) DCs, namely Langerhan's cells... - Isolation of human blood DC subtypesAndrew J Kassianos
Mater Medical Research Institute, South Brisbane, QLD, Australia
Methods Mol Biol 595:45-54. 2010..CD11c(+) myeloid DC, which can be further subdivided into three subsets based on differential expression of CD1c, CD141 and CD16... - IL-32-dependent effects of IL-1beta on endothelial cell functionsClaudia A Nold-Petry
Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 106:3883-8. 2009..In contrast, the anti-inflammatory/anti-coagulant CD141/thrombomodulin increased markedly when IL-32 was silenced... - Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein CLikui Yang
Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Proc Natl Acad Sci U S A 103:879-84. 2006..The binding of Ca(2+) to the 70-80 loop of protein C inhibits protein C activation by thrombin in the absence of thrombomodulin (TM), but the metal ion is required for activation in the presence of TM... - Thrombomodulin and its role in inflammationEdward M Conway
Division of Hematology Oncology, Department of Medicine, Centre for Blood Research CBR, University of British Columbia, Vancouver, BC, Canada
Semin Immunopathol 34:107-25. 2012The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data were collected from published research... - The fate of renal allografts hinges on responses of the microvascular endotheliumVenkat K R Mannam
Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA
Exp Mol Pathol 94:398-411. 2013..were positive for HLA-ABC, HLA-DR/DQ, von Willebrand factor, endoglin, PECAM, ICAM, MCAM, integrin beta-3, thrombomodulin, E-selectin, VCAM-1, and tissue factor, and negative for alpha smooth muscle actin and P-selectin antibodies... - Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health statusDiana Mittag
Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
J Immunol 186:6207-17. 2011..We identify three conventional DC subsets characterized by surface expression of CD1b/c, CD141, and CD16, and one plasmacytoid DC subset characterized by CD304 expression... - Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombinLaurent O Mosnier
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 286:502-10. 2011b>Thrombomodulin (TM) is a cofactor for thrombin-mediated activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI) and thereby helps coordinate coagulation, anticoagulation, fibrinolysis, and inflammation... - Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly ICHenning Lauterbach
Department of Research Immunology, Bavarian Nordic GmbH, 82152 Martinsried, Germany
J Exp Med 207:2703-17. 2010..Human DCs expressing BDCA3 (CD141), which is considered to be the human counterpart of murine CD8α(+) DCs, also produced large amounts of .. - Impaired binding of thrombin to thrombomodulin is associated with risk of deep vein thrombosisEtsuji Suehisa
Laboratory for Clinical Investigation, Osaka University Hospital, Suita City, Osaka, Japan
Thromb Res 123:85-92. 2008The complex of thrombin and thrombomodulin (TM) activates protein C, and impaired binding of thrombin to TM may be a risk factor for thrombosis... - Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p)D R Maglott
American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852-1776, USA
Mamm Genome 7:400-1. 1996 - Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicityHartmut Geiger
Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Nat Med 18:1123-9. 2012..Here we identify the thrombomodulin (Thbd)-activated protein C (aPC) pathway as a new mechanism for the mitigation of total body irradiation (TBI)-.. - Ets-1 mediates platelet-derived growth factor-BB-induced thrombomodulin expression in human vascular smooth muscle cellsI Chung Lo
Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan, Republic of China
Cardiovasc Res 81:771-9. 2009b>Thrombomodulin (TM), a potent anticoagulant, is not detected in quiescent vascular smooth muscle cells (VSMCs). In diseased vessels, VSMC expresses TM, but the mechanisms are unclear... - [Effect of C5a on expression of thrombomodulin in endothelial cells in vitro]Wei Fang
Guangzhou Medical College, Guangzhou 510010, Guangdong, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:168-71. 2009To investigate the effect of C5a on the expression of thrombomodulin (TM) in human umbilical vein endothelial cells (HUVECs). - Thrombomodulin gene polymorphisms in brain infarction and mortality after strokeJean Marc Olivot
INSERM U698 and Denis Diderot University Paris VII, Dept of Neurology and Stroke Center, Bichat University Hospital, Paris, France
J Neurol 255:514-9. 2008b>Thrombomodulin is expressed at the surface of endothelial cells and controls thrombin generation and thrombin-induced platelets and vascular cell activation... - The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?B Steiniger
Institute of Anatomy and Cell Biology, University of Marburg, Robert Koch Str 6, D 35033 Marburg, Germany
Am J Pathol 159:501-12. 2001..and VAP-1; the Thy-1 (CD90) molecule; smooth muscle alpha-actin and smooth muscle myosin; cytokeratin 18; and thrombomodulin (CD141)... - Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosisBerend Isermann
Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
Nat Med 13:1349-58. 2007..Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally linked to nephropathy... - Genetic risk for restenosis after coronary balloon angioplastyHideki Horibe
Department of Cardiology, Kosei Hospital, Anjo, Japan
Atherosclerosis 174:181-7. 2004..that two polymorphisms (242C --> T in the NADH/NADPH oxidase p22 phox (p22-PHOX) gene and 2136C --> T in the thrombomodulin (THBD) gene) in men and two polymorphisms (584G --> A in the paraoxonase 1 (PON1) gene and 2445G --> A in the .. - Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cellsK M Silk
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
Gene Ther 19:1035-40. 2012..Unlike moDC, a subset of ipDC was found to coexpress CD141 and XCR1 that have been shown previously to define the human equivalent of mouse CD8α(+) DC, in which the .. - Thrombomodulin links coagulation to inflammation and immunityJohn Morser
Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, MC5156, Stanford, CA 9435 5156, USA
Curr Drug Targets 13:421-31. 2012b>Thrombomodulin (TM) is a type 1 membrane bound glycoprotein that has a C-type lectin domain at its Nterminus, 6 copies of the epidermal growth factor-like (EGF) motif and serine/threonine rich domain carrying a glycosoaminoglycan external .. - Best immunohistochemical panel in distinguishing adenocarcinoma from squamous cell carcinoma of lung: tissue microarray assay in resected lung cancer specimensMi Jin Kim
Department of Pathology, Yeungnam University College of Medicine, Nam Gu, Daegu, South Korea
Ann Diagn Pathol 17:85-90. 2013..using tissue microarray for napsin-A, Thyroid transcription factor 1 (TTF-1), p63, cytokeratin (CK) 5/6, thrombomodulin (CD141), Epithelial-related antigen (MOC-31), carcinoembryonic antigen (CEA), Cyclooxygenase 2 (COX-2), high-.. - Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signalingTakayuki Ikezoe
Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
Arterioscler Thromb Vasc Biol 32:2259-70. 2012We have recently reported that recombinant human soluble thrombomodulin (rTM) counteracted capillary leakage associated with engraftment, as well as sinusoidal obstructive syndrome after hematopoietic stem cell transplantation... - Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitroLing Yuh Shyu
Institute of Medicine, Chung Shan Medical University, Taiwan, ROC
Thromb Res 129:43-9. 2012..In this study, we investigated the potential role of MIF in coagulation through its influence on two factors, thrombomodulin (TM) and intercellular adhesion molecule-1 (ICAM-1)... - Atypical hemolytic uremic syndrome in children: complement mutations and clinical characteristicsLianne M Geerdink
Department of Pediatric Nephrology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Pediatr Nephrol 27:1283-91. 2012Mutations in complement factor H (CFH), factor I (CFI), factor B (CFB), thrombomodulin (THBD), C3 and membrane cofactor protein (MCP), and autoantibodies against factor H (αFH) with or without a homozygous deletion in CFH-related protein .. - Naturally occurring CD1c+ human regulatory dendritic cells: immunoregulators that are expanded in response to E. coli infectionCheng Qian
National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, China
Eur J Immunol 42:1388-92. 2012..Initial studies of DCs in human blood revealed that steady-state myeloid DCs are comprised of the CD141(+) and CD1c(+) DC subsets as the equivalents to the mouse lymphoid resident CD8(+) and CD8(-) DC subsets, .. - Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coliAndrew J Kassianos
Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland, Australia
Eur J Immunol 42:1512-22. 2012Human blood myeloid DCs can be subdivided into CD1c (BDCA-1)(+) and CD141 (BDCA-3)(+) subsets that display unique gene expression profiles, suggesting specialized functions... - Professional Cross-Presenting CD8α-Type CD141(hi) Dendritic Cells: We Have Got You in Our Skin!Marc Dalod
Centre d immunologie de Marseille Luminy, Aix Marseille Université UM2, Campus de Luminy case 906, 13288 Marseille, France INSERM, UMR1104, 13288 Marseille, France CNRS, UMR7280, 13288 Marseille, France
Immunity 37:3-5. 2012..2012) identify the presence of professional cross-presenting human dendritic cells in the skin, the liver, and the lung and also presented comparative genomics to align human and mouse dendritic cell types across tissues... - Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesisCheol Min Shin
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Cancer Sci 101:1337-46. 2010..pylori. Aberrant methylation of THBD might provide a link between H. pylori infection and development of GC... - Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cellsAnnabell Bachem
Molecular Immunology, Robert Koch Institute, 13353 Berlin, Germany
J Exp Med 207:1273-81. 2010..into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets... - JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoterYuanyuan Rong
The Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong, China
FEBS Lett 584:852-8. 2010b>Thrombomodulin (TM) is an important vascular protective molecule that has anticoagulant, anti-inflammatory and anti-apoptotic properties. TM is downregulated in many thrombotic and vascular diseases... - Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthmaM Spears
Department of Respiratory Medicine, Institute of Infection, Immunity and Inflammation, Gartnavel General Hospital, University of Glasgow, Glasgow, UK
Clin Exp Allergy 41:665-72. 2011..Smokers with asthma display altered therapeutic behaviour and a reduction in endobronchial DC CD83 expression compared with non-smokers with asthma. No information is available on the impact of smoking on peripheral blood DC profiles... - Mutations in the thrombomodulin and endothelial protein C receptor genes in women with late fetal lossF Franchi
The Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, I R C C S Maggiore Hospital and Department of Internal Medicine, University of Milan, Italy
Br J Haematol 114:641-6. 2001Late fetal loss can be associated with placental insufficiency and coagulation defects. Thrombomodulin (TM) and the endothelial protein C receptor (EPCR) are glycoprotein receptors expressed mainly on the endothelial surface of blood .. - Increased P-selectin expression on platelets and decreased plasma thrombomodulin in Fontan patientsHidemi Kajimoto
Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
Circ J 73:1705-10. 2009..P-selectin on platelets indicates platelet activation. Thrombomodulin (TM), a receptor for thrombin and a major anticoagulant proteoglycan on the endothelial membrane, reflects the .. - Thrombomodulin mutations in atypical hemolytic-uremic syndromeMieke Delvaeye
VIB K U Leuven Vesalius Research Center, Leuven, Belgium
N Engl J Med 361:345-57. 2009..Genetic factors in the remaining cases are unknown. We studied the role of thrombomodulin, an endothelial glycoprotein with anticoagulant, antiinflammatory, and cytoprotective properties, in atypical .. - Valves of the deep venous system: an overlooked risk factorErin G Brooks
Department of Pathology, University of Vermont, Burlington, VT 05482, USA
Blood 114:1276-9. 2009..In pursuit of this hypothesis, we quantified endothelial protein C receptor (EPCR), thrombomodulin (TM), and von Willebrand factor (VWF) by immunofluorescence in great saphenous veins harvested at cardiac .. - Thrombomodulin, calretinin and c-kit (CD117) expression in cardiac myxomaE Acebo
Department of Anatomical Pathology, Marques de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Santander, Spain
Histol Histopathol 16:1031-6. 2001..This study comprised the immunoreactivity of the tumors for thrombomodulin, calretinin and and c-kit (CD117)... - Increased levels of endothelial haemostatic markers in patients with coronary heart diseaseAnita Schumacher
Department of Microbiology, Vestfold Central Hospital, Tønsberg, Norway
Thromb Res 105:25-31. 2002von Willebrand factor (vWF), thrombomodulin and tissue plasminogen activator antigen (tPAag) are regarded as markers of endothelial activation and/or damage. Elevated levels have been associated with atherosclerotic disease states... - Thrombomodulin gene variations and thromboembolic diseaseA K Ohlin
Department of Laboratory Medicine, University Hospital, Lund, Sweden
Thromb Haemost 78:396-400. 1997b>Thrombomodulin (TM) is the endothelial cell cofactor for protein C activation... - aHUS caused by complement dysregulation: new therapies on the horizonAoife M Waters
Department of Nephrology, Great Ormond Street Hospital, London, WC1N 3JH, UK
Pediatr Nephrol 26:41-57. 2011..More recently, mutations have also been identified in thrombomodulin (THBD), an anticoagulant glycoprotein that plays a role in the inactivation of C3a and C5a... - Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transitionYuan Chung Kao
Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Mol Cell Biol 30:4767-85. 2010The expression of thrombomodulin (TM), a calcium-dependent adhesion molecule, is frequently downregulated in various cancer types. However, the mechanism responsible for the low expression level of TM in tumorigenesis is unknown... - Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assaysS Imada
Division of Cell Biology, Meiji Institute of Health Science, Meiji Milk Products Co Ltd, Odawara, Japan
Dev Biol 140:113-22. 1990..We now show by protein and DNA sequencing and by functional assays that FM is identical to thrombomodulin, an anticoagulant endothelial thrombin receptor... - The roles of protein C and thrombomodulin in the regulation of blood coagulationC T Esmon
Howard Hughes Medical Institute, Oklahoma Medical Research Foundation, Oklahoma City 73104
J Biol Chem 264:4743-6. 1989 - Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activationK Suzuki
Department of Laboratory Medicine, Mie University School of Medicine, Japan
EMBO J 6:1891-7. 1987We have deduced the entire 575-amino acid sequence of the human thrombomodulin precursor from cDNA clones... - Loss of Arnt (Hif1β) in mouse epidermis triggers dermal angiogenesis, blood vessel dilation and clotting defectsAssefa Wondimu
Department of Dermatology, Columbia University, New York, NY, USA
Lab Invest 92:110-24. 2012.... - Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analysesRobert L Lobato
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
Circulation 124:S143-8. 2011..We tested the hypothesis that genetic variation in thrombotic and inflammatory pathways is independently associated with long-term mortality after coronary artery bypass graft (CABG) surgery... - Common variants in the haemostatic gene pathway contribute to risk of early-onset myocardial infarction in the Italian populationIlaria Guella
Department of Biology and Genetics for Medical Sciences, University of Milan, Milano, Italy
Thromb Haemost 106:655-64. 2011..69-fold increased risk for MI compared with those in the lowest quintile. Our results suggest that a GRS, based on the combined effect of several risk alleles in different haemostatic genes, is associated with an increased risk of MI... - Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein CT Shirai
Bio Science Laboratory, Asahi Chemical Industry, Shizuoka
J Biochem 103:281-5. 1988The gene coding for human thrombomodulin, a thrombin receptor on endothelial cells and a cofactor for the activation of anticoagulant protein C zymogen, was isolated from a human genomic library by employing human thrombomodulin cDNA as a .. - Immunohistochemical localization of thrombomodulin in chorionic diseases of the uterus and choriocarcinoma of the stomach. A comparative study with the distribution of human chorionic gonadotropinS Yonezawa
Department of Pathology, Kagoshima University School of Medicine, Japan
Cancer 62:569-76. 1988b>Thrombomodulin (TM) is a newly described protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant... - Sources of thrombomodulin in pre-eclampsia: renal dysfunction or endothelial damage?Luci Dusse
Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Brazil
Semin Thromb Hemost 37:153-7. 2011..Among others, plasma thrombomodulin (TM) level rises significantly... - Structure of the fifth EGF-like domain of thrombomodulin: An EGF-like domain with a novel disulfide-bonding patternB A Sampoli Benitez
Department of Chemistry and Biochemistry, University of California, San Diego, CA 92093 0601, USA
J Mol Biol 273:913-26. 1997The structure of the fifth EGF-like domain (residues Q387 to E426) of thrombomodulin (TMEGF5) has been determined by two-dimensional NMR. TMEGF5 binds to thrombin with a Ki of 1... - Thrombomodulin and von Willebrand factor: relation to endothelial dysfunction and disease outcome in children with acute lymphoblastic leukemiaEmmanouel S Hatzipantelis
Department of Paediatrics, AHEPA Hospital, Thessaloniki, Greece
Acta Haematol 125:130-5. 2011..In children with ALL, there was a significant increase in thrombomodulin (TM) and von Willebrand factor (vWF) levels during the acute phase of the disease and during treatment... - The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulinM Adler
Berlex Bioscience, Inc, Richmond, California 94804 0099, USA
J Biol Chem 270:23366-72. 1995..of this peptide is based on the C-loop, residues 371-389, of the fourth epidermal growth factor-like domain of thrombomodulin, a protein that acts as a cofactor for the thrombin activation of protein C... - Thrombomodulin and GFC levels in Legg-Calve-Perthes diseaseM Cemalettin Aksoy
Department of Orthopedics and Traumatology, Hacettepe University Medical School, 06100 Sihhiye, Ankara, Turkey
Hematology 13:324-8. 2008..Circulating soluble thrombomodulin (TM) reflects endothelial activation and/or injury... - Silencing of the thrombomodulin gene in human malignant melanomaJunichi Furuta
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
Melanoma Res 15:15-20. 2005The loss of thrombomodulin (TM) expression is associated with tumour growth, infiltration and lymph node metastasis in human tumours... - Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese populationShoko Sugiyama
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
Thromb Res 119:35-43. 2007b>Thrombomodulin (TM) is an essential cofactor in protein C activation by thrombin. Here, we evaluated the contribution of genetic variations in the TM gene to soluble TM (sTM) level and deep vein thrombosis (DVT) in Japanese. - Decreased plasma soluble thrombomodulin levels as a risk factor for pulmonary thromboembolismYu Dong Yin
Beijing Institute of Respiratory Medicine, Beijing Chao Yang Hospital, Capital Medical University, Beijing, People s Republic of China
J Thromb Thrombolysis 27:274-9. 2009To observe the changes of the plasma soluble thrombomodulin (sTM) concentrations in patients with pulmonary thromboembolism (PTE) and assess the association between plasma sTM concentration and the risk of PTE.
Research Grants
- INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLSLloyd Mayer; Fiscal Year: 2007In this R-01 granting period we have identified an apoptotic protein isolated from the CD141/low CD16/high 43/HIV human macrophage hybridoma cell line...
- INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLSKirk Sperber; Fiscal Year: 2005In this R-01 granting period we have identified an apoptotic protein isolated from the CD141/low CD16/high 43/HIV human macrophage hybridoma cell line...
- ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHYCHARLENE HAFER MACKO; Fiscal Year: 2002..We also found that thrombomodulin (TM), an endothelial membrane receptor that deactivates thrombin and accelerates activated protein C formation ..
- Genetic Reg. of Hematopoietic Stem Cell MobilizationHartmut Geiger; Fiscal Year: 2007..g. to muscle tissue, or to other hematopoietic niches. ..
- RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN THE COMMUNITYJohn A Heit; Fiscal Year: 2010..This study aims to prevent these deaths by identifying the individual person at high risk and preventing venous thromboembolism. ..
- Direct Cellular Effects of Blood Coagulation ProteasesLAURENT MOSNIER; Fiscal Year: 2007..I propose: 1) To characterize the formation of endothelial cell membrane receptor complexes between thrombomodulin, endothelial protein C receptor and protease activated receptor-1 required for APC generation and APC's direct ..
- Mayo Clinic Vascular Medicine Clinical Research Training ProgramJohn Heit; Fiscal Year: 2007..In addition, this research will teach doctors how to discover new causes of diseases of arteries, veins and lymph vessels, as well as new ways to prevent and treat these diseases. ..
- Individual Propensity to Venous ThrombosisJohn Heit; Fiscal Year: 2009..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..
- RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN THE COMMUNITYJohn Heit; Fiscal Year: 2007..This data will provide insights regarding the effect of new prophylaxis drugs on VTE incidence and why some but not most high-risk patients develop VTE, and test the effect of outpatient LMWH therapy on VTE recurrence. ..
- RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN THE COMMUNITYJohn Heit; Fiscal Year: 2004..Finally, the investigators will plan to extend their analysis of current VTE in relationship to use of standard heparin and low molecular weight heparin. ..
- Individual Propensity to Venous ThrombosisJohn Heit; Fiscal Year: 2007..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..
- Structure-function of cytoprotective coagulation proteases and their receptorsLAURENT OLIVIER MOSNIER; Fiscal Year: 2011..associated with "off-target" Heparin-Induced Thrombocytopenia (HIT) antibodies against PF4-EPCR and PF4-thrombomodulin (TM) complexes...