thrombomodulin

Summary

Gene Symbol: thrombomodulin
Description: thrombomodulin
Alias: AHUS6, BDCA3, CD141, THPH12, THRM, thrombomodulin, CD141 antigen, fetomodulin
Species: human
Products:     thrombomodulin

Top Publications

  1. Yerkovich S, Roponen M, Smith M, McKenna K, Bosco A, Subrata L, et al. Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response. J Allergy Clin Immunol. 2009;123:209-216.e4 pubmed publisher
    ..b>Thrombomodulin (CD141, blood dendritic cell antigen 3) expression by microarray was higher on HDM-stimulated DCs from atopic (..
  2. Auro K, Komulainen K, Alanne M, Silander K, Peltonen L, Perola M, et al. Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up study. Arterioscler Thromb Vasc Biol. 2006;26:942-7 pubmed
    b>Thrombomodulin is an anticoagulant expressed during endothelial activation and damage...
  3. Yin Y, Wang C, Zhai Z, Pang B, Yang Y, Huang X. Decreased plasma soluble thrombomodulin levels as a risk factor for pulmonary thromboembolism. J Thromb Thrombolysis. 2009;27:274-9 pubmed publisher
    To observe the changes of the plasma soluble thrombomodulin (sTM) concentrations in patients with pulmonary thromboembolism (PTE) and assess the association between plasma sTM concentration and the risk of PTE...
  4. Jongbloed S, Kassianos A, McDonald K, Clark G, Ju X, Angel C, et al. Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J Exp Med. 2010;207:1247-60 pubmed publisher
    ..We report the first detailed functional analysis of the human CD141+ DC subset...
  5. Lobato R, White W, Mathew J, Newman M, Smith P, McCants C, et al. Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses. Circulation. 2011;124:S143-8 pubmed publisher
    ..comparisons and clinical predictors of mortality, the homozygote minor allele of a common variant in the thrombomodulin (THBD) gene (rs1042579) was independently associated with significantly increased risk of all-cause mortality (..
  6. Ranjith N, Pegoraro R, Rom L. Haemostatic gene polymorphisms in young indian asian subjects with acute myocardial infarction. Med Sci Monit. 2003;9:CR417-21 pubmed
    ..We investigated the relationship between polymorphisms in the Factor V (Leiden), prothrombin (20210 GgA) and thrombomodulin (Ala455Val) genes in patients with a myocardial infarction (MI) <45 years of age (n=195) and in unaffected ..
  7. Park H, Nabika T, Jang Y, Kwon H, Cho S, Masuda J. Association of G-33A polymorphism in the thrombomodulin gene with myocardial infarction in Koreans. Hypertens Res. 2002;25:389-94 pubmed
    b>Thrombomodulin (TM), a thrombin receptor expressed on the endothelial surface, is known to play an important role in the anti-thrombogenic system in vivo...
  8. Dogra R, Das R, Ahluwalia J, Kumar R, Talwar K. Association of thrombomodulin gene polymorphisms and plasma thrombomodulin levels with acute myocardial infarction in north Indian patients. Clin Appl Thromb Hemost. 2013;19:637-43 pubmed publisher
    This is the first study from north India that investigated the association of thrombomodulin (TM) polymorphisms with acute myocardial infarction (AMI) in 350 patients (? 40 years, n = 184 and ? 60 years, n = 166) and 350 matched-controls...
  9. Kaare M, Ulander V, Painter J, Ahvenainen T, Kaaja R, Aittomaki K. Variations in the thrombomodulin and endothelial protein C receptor genes in couples with recurrent miscarriage. Hum Reprod. 2007;22:864-8 pubmed
    ..Loss of function of two of these genes, thrombomodulin (TM) and endothelial protein C receptor (EPCR), causes embryonic lethality in mice...

More Information

Publications83

  1. Zhao J, Zhou X, Huang J, Chen J, Gu D. Association study of the thrombomodulin -33G>A polymorphism with coronary artery disease and myocardial infarction in Chinese Han population. Int J Cardiol. 2005;100:383-8 pubmed
    b>Thrombomodulin (TM) is the anticoagulant endothelial cell membrane-bound protein cofactor in the thrombin-mediated activation of protein C...
  2. Ishii H, Majerus P. Thrombomodulin is present in human plasma and urine. J Clin Invest. 1985;76:2178-81 pubmed
    b>Thrombomodulin is an endothelial cell membrane protein that is a cofactor required for the rapid activation of plasma protein C...
  3. Shyu L, Yeh T, Chang H, Lin D, Teng Y, Chen L, et al. Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro. Thromb Res. 2012;129:43-9 pubmed publisher
    ..In this study, we investigated the potential role of MIF in coagulation through its influence on two factors, thrombomodulin (TM) and intercellular adhesion molecule-1 (ICAM-1)...
  4. Ishibazawa A, Nagaoka T, Takahashi T, Yamamoto K, Kamiya A, Ando J, et al. Effects of shear stress on the gene expressions of endothelial nitric oxide synthase, endothelin-1, and thrombomodulin in human retinal microvascular endothelial cells. Invest Ophthalmol Vis Sci. 2011;52:8496-504 pubmed publisher
    ..The mRNA expressions of endothelial nitric oxide synthase (eNOS), endothelin-1 (ET-1), and thrombomodulin (TM) in the HRMECs were evaluated using real-time reverse transcription polymerase chain reaction...
  5. Gupta M, Kolli D, Garofalo R. Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection. Respir Res. 2013;14:71 pubmed publisher
    ..Findings of differential expression of PD-L1 and IL-10 by infected mDCs, suggests possible mechanisms by which RSV is able to impair adaptive immune responses. ..
  6. Aleksic N, Folsom A, Cushman M, Heckbert S, Tsai M, Wu K. Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE Study. J Thromb Haemost. 2003;1:88-94 pubmed
    Plasma thrombomodulin (soluble TM; sTM) is considered to be a marker of endothelial injury, but a recent report indicated that the relationship of sTM with thrombosis is complex...
  7. Ishii H, Tezuka T, Ishikawa H, Takada K, Oida K, Horie S. Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the T. Blood. 2003;101:4765-74 pubmed
    The present work investigated the mechanism for down-regulation of thrombomodulin (TM), an anticoagulant glycoprotein, on cultured umbilical vein endothelial cells (HUVECs) exposed to lipid extracts from oxidized low-density lipoprotein (..
  8. Nakazawa F, Koyama T, Shibamiya A, Hirosawa S. Characterization of thrombomodulin gene mutations of the 5'-regulatory region. Atherosclerosis. 2002;164:385-7 pubmed
  9. Wu C, Chang Y, Lin P, Chen W, Chen M. Thrombomodulin expression regulates tumorigenesis in bladder cancer. BMC Cancer. 2014;14:375 pubmed publisher
    The identification of potential tumor markers will help improve therapeutic planning and patient management. Thrombomodulin (TM) is a sensitive urothelial marker...
  10. Norlund L, Holm J, Zoller B, Ohlin A. A common thrombomodulin amino acid dimorphism is associated with myocardial infarction. Thromb Haemost. 1997;77:248-51 pubmed
    ..b>Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C ..
  11. Kao Y, Wu L, Shi C, Chu C, Huang C, Kuo C, et al. Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition. Mol Cell Biol. 2010;30:4767-85 pubmed publisher
    The expression of thrombomodulin (TM), a calcium-dependent adhesion molecule, is frequently downregulated in various cancer types. However, the mechanism responsible for the low expression level of TM in tumorigenesis is unknown...
  12. Nocchi L, Tomasetti M, Amati M, Neuzil J, Santarelli L, Saccucci F. Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism. J Biol Chem. 2011;286:19478-88 pubmed publisher
    Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process...
  13. Sohn R, Deming C, Johns D, Champion H, Bian C, Gardner K, et al. Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B. Blood. 2005;105:3910-7 pubmed
    ..Endothelial cell expression of thrombomodulin (TM), a key component of the anticoagulant protein C pathway, is potently inhibited by inflammatory cytokines...
  14. Bachem A, Güttler S, Hartung E, Ebstein F, Schaefer M, Tannert A, et al. Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells. J Exp Med. 2010;207:1273-81 pubmed publisher
    ..into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets...
  15. Kunz G, Ohlin A, Adami A, Zöller B, Svensson P, Lane D. Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function. Blood. 2002;99:3646-53 pubmed
    Sporadic mutations in the thrombomodulin (TM) gene occur in patients with both arterial and venous thrombosis, but the effects of these mutations on expression and function are largely unexplored...
  16. Furuta J, Kaneda A, Umebayashi Y, Otsuka F, Sugimura T, Ushijima T. Silencing of the thrombomodulin gene in human malignant melanoma. Melanoma Res. 2005;15:15-20 pubmed
    The loss of thrombomodulin (TM) expression is associated with tumour growth, infiltration and lymph node metastasis in human tumours...
  17. Conway E. Thrombomodulin and its role in inflammation. Semin Immunopathol. 2012;34:107-25 pubmed publisher
    The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data were collected from published research...
  18. Doggen C, Kunz G, Rosendaal F, Lane D, Vos H, Stubbs P, et al. A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men. Thromb Haemost. 1998;80:743-8 pubmed
    b>Thrombomodulin is an endothelial cell surface receptor that transforms the procoagulant thrombin into an anticoagulant. A mutation in the thrombomodulin gene is a potential risk factor for venous and arterial thrombosis...
  19. Li Y, Chen J, Tsai W, Chao T, Guo H, Tsai L, et al. Synergistic effect of thrombomodulin promoter -33G/A polymorphism and smoking on the onset of acute myocardial infarction. Thromb Haemost. 2002;87:86-91 pubmed
    b>Thrombomodulin is an endothelial cell surface receptor for thrombin. It plays an important role in the regulation of blood coagulation by decreasing thrombin activity and activating protein C...
  20. Yang L, Manithody C, Walston T, Cooper S, Rezaie A. Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin. J Biol Chem. 2003;278:37465-70 pubmed
    b>Thrombomodulin (TM), or its epidermal growth factor-like domains 456 (TM456), enhances the catalytic efficiency of thrombin toward both protein C and protein C inhibitor (PCI) by 2-3 orders of magnitude...
  21. Van de Wouwer M, Collen D, Conway E. Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. Arterioscler Thromb Vasc Biol. 2004;24:1374-83 pubmed
    ..Most of these can be traced to the vasculature, where the systems most intimately interact. Thrombomodulin (TM), a cell surface-expressed glycoprotein, predominantly synthesized by vascular endothelial cells, is a ..
  22. Konstantoulas C, Cooper J, Warnock G, Miller G, Humphries S, Ireland H. A combination of two common thrombomodulin gene variants (-1208-1209TTdelTT and A455V) influence risk of coronary heart disease: a prospective study in men. Atherosclerosis. 2004;177:97-104 pubmed
    ..study of myocardial infarction (MI), we identified risk associated with the combination of two variants in the thrombomodulin (TM) gene (-1208-1209TTdelTT and A455V) and an interaction with increased body mass index (BMI)...
  23. Esmon C. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J. 1995;9:946-55 pubmed
    ..The pathway is initiated when thrombin binds to the endothelial cell thrombin binding protein, thrombomodulin. The complex exhibits dramatically altered macromolecular specificity...
  24. Nan B, Yang H, Yan S, Lin P, Lumsden A, Yao Q, et al. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery. 2005;138:212-22 pubmed
    ..The objective of the present study was to determine the effect of CRP on the expression of thrombomodulin (TM) and the endothelial protein C receptor (EPCR) in human endothelial cells...
  25. Wu K, Aleksic N, Ahn C, Boerwinkle E, Folsom A, Juneja H. Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease. Circulation. 2001;103:1386-9 pubmed
    b>Thrombomodulin (TM) is expressed on the endothelial surface and plays an important role in vasoprotection...
  26. David Dufilho M, Millanvoye Van Brussel E, Topal G, Walch L, Brunet A, Rendu F. Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II. J Biol Chem. 2005;280:35999-6006 pubmed
    Endothelial membrane-bound thrombomodulin is a high affinity receptor for thrombin to inhibit coagulation...
  27. Sugiyama S, Hirota H, Kimura R, Kokubo Y, Kawasaki T, Suehisa E, et al. Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese population. Thromb Res. 2007;119:35-43 pubmed
    b>Thrombomodulin (TM) is an essential cofactor in protein C activation by thrombin. Here, we evaluated the contribution of genetic variations in the TM gene to soluble TM (sTM) level and deep vein thrombosis (DVT) in Japanese...
  28. Shah S, Ashavaid T, Mankeshwar R, Ponde C, Rajani R. Role of thrombomodulin gene in Indian population with coronary artery disease. Biomarkers. 2012;17:610-7 pubmed publisher
    b>Thrombomodulin (TM), a natural anticoagulant have been implicated in the pathogenesis of coronary artery disease (CAD) thus emphasizing its potential role as a biomarker...
  29. Iwata M, Kawahara K, Kawabata H, Ito T, Mera K, Biswas K, et al. Thrombomodulin exerts cytoprotective effect on low-dose UVB-irradiated HaCaT cells. Biochem Biophys Res Commun. 2008;377:642-647 pubmed publisher
    b>Thrombomodulin (TM) is an endothelial cell surface anticoagulant glycoprotein that performs antimetastatic, angiogenic, adhesive, and anti-inflammatory functions in various tissues. It is also expressed in epidermal keratinocytes...
  30. Rong Y, Zhang M, Zhang L, Wang X, Shen Y. JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter. FEBS Lett. 2010;584:852-8 pubmed publisher
    b>Thrombomodulin (TM) is an important vascular protective molecule that has anticoagulant, anti-inflammatory and anti-apoptotic properties. TM is downregulated in many thrombotic and vascular diseases...
  31. Chao T, Li Y, Chen J, Wu H, Shi G, Tsai W, et al. Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients <or =50 years of age. Am J Cardiol. 2004;93:204-7 pubmed
    Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI)...
  32. Cao Y, Zhang Z, Xu J, Yuan W, Wang J, Huang X, et al. The association of idiopathic recurrent pregnancy loss with polymorphisms in hemostasis-related genes. Gene. 2013;530:248-52 pubmed publisher
    ..study were to investigate the effects of polymorphisms in hemostasis-related genes antithrombin (SERPINC1), thrombomodulin (THBD), tissue factor pathway inhibitor (TFPI), factor V, factor II and annexin A5 (ANXA5), involved in ..
  33. Johansson L, Jansson J, Boman K, Nilsson T, Stegmayr B, Hallmans G. Prospective study on soluble thrombomodulin and von Willebrand factor and the risk of ischemic and hemorrhagic stroke. Thromb Haemost. 2002;87:211-7 pubmed
    The aim of the present study was to examine if soluble thrombomodulin (sTM) and von Willebrand factor (VWF) could predict a first-ever ischemic or hemorrhagic stroke...
  34. Breton G, Zheng S, Valieris R, Tojal da Silva I, Satija R, Nussenzweig M. Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs. J Exp Med. 2016;213:2861-2870 pubmed
    ..conventional dendritic cells (cDCs) exist as two unique populations characterized by expression of CD1c and CD141. cDCs arise from increasingly restricted but well-defined bone marrow progenitors that include the common DC ..
  35. Hu B, Wang Q, Tang L, Hu Y. Association of thrombomodulin c.1418C>T polymorphism and venous thromboembolism. Gene. 2017;628:56-62 pubmed publisher
    To investigate the association between thrombomodulin c.1418C>T polymorphism and venous thrombosis...
  36. Friedrich V, Bi W, Sehba F. Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage. Neurol Res. 2015;37:1054-9 pubmed publisher
    ..Cerebral RNA was extracted at sacrifice 3 h after surgery and assayed for expression of thrombomodulin (Thbd), endothelial nitric oxide synthase (eNos;Nos3), intracellular adhesion molecule-1 (Icam1), vascular ..
  37. Hira B, Pegoraro R, Rom L, Govender T, Moodley J. Polymorphisms in various coagulation genes in black South African women with placental abruption. BJOG. 2002;109:574-5 pubmed
    This pilot study examined Factor V Leiden (R506Q), prothrombin (20210G-->A), thrombomodulin (A455V) and MTHFR (677C-->T) in 100 Zulu-speaking black South African women with placental abruption and 217 controls...
  38. Thergaonkar R, Narang A, Gurjar B, Tiwari P, Puraswani M, Saini H, et al. Targeted exome sequencing in anti-factor H antibody negative HUS reveals multiple variations. Clin Exp Nephrol. 2018;22:653-660 pubmed publisher
    ..Population data on variation frequency of the Indian population and supportive functional studies are likely to improve diagnostic yield. ..
  39. Ikezoe T, Yang J, Nishioka C, Pan B, Xu K, Furihata M, et al. The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model. Bone Marrow Transplant. 2017;52:73-79 pubmed publisher
    The present study found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an ..
  40. Yang P, Wei X, Zhang J, Yi B, Zhang G, Yin L, et al. Antithrombotic Effects of Nur77 and Nor1 Are Mediated Through Upregulating Thrombomodulin Expression in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2016;36:361-9 pubmed publisher
    b>Thrombomodulin is highly expressed on the lumenal surface of vascular endothelial cells (ECs) and possesses potent anticoagulant, antifibrinolytic, and anti-inflammatory activities in the vessel wall...
  41. Saigo K, Mori C, Iwamoto S, Shirai K, Uematsu T, Takenokuchi M, et al. Recombinant thrombomodulin does not impair neutrophil functions. J Thromb Thrombolysis. 2015;39:536-8 pubmed publisher
  42. Dai L, Mitchell M, Savidge G, Alhaq A. The profibrinolytic effect of plasma thrombomodulin in factor XI deficiency and its implications in hemostasis. J Thromb Haemost. 2004;2:2200-4 pubmed
    ..b>Thrombomodulin (TM), upon binding to thrombin, is capable of modulating TAFI activation...
  43. Chang Y, Cheng Y, Lin R, Huang C, Chen W, Ke T, et al. Thrombomodulin Influences the Survival of Patients with Non-Metastatic Colorectal Cancer through Epithelial-To-Mesenchymal Transition (EMT). PLoS ONE. 2016;11:e0160550 pubmed publisher
    ..Therefore, the identification of new markers for CRC remains important. Thrombomodulin (TM), a glycoprotein, is involved in angiogenesis and has been linked to many malignant diseases...
  44. Andrulis M, Dietrich S, Longerich T, Koschny R, Burian M, Schmitt Gräf A, et al. Loss of endothelial thrombomodulin predicts response to steroid therapy and survival in acute intestinal graft-versus-host disease. Haematologica. 2012;97:1674-7 pubmed publisher
    ..Endothelial thrombomodulin was quantified along with histological markers of epithelial damage and cytotoxic T cells in colon biopsies ..
  45. Kim H, Kim J, Chung J, Kim Y, Kang S, Han K, et al. Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line. Blood Coagul Fibrinolysis. 2007;18:157-64 pubmed
    b>Thrombomodulin has a central role in the regulation of coagulation through its abilities to promote generation of the potent anticoagulant activated protein C...
  46. Jackman R, Beeler D, Fritze L, Soff G, Rosenberg R. Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control. Proc Natl Acad Sci U S A. 1987;84:6425-9 pubmed
    We have isolated a human thrombomodulin cDNA, and a human genomic clone containing the putative promoter domain, as well as the translated and untranslated regions of the endothelial cell receptor...
  47. Jiménez J, Prasad V, Yu M, Kampmeyer C, Kaakour A, Wang P, et al. Macro- and microscale variables regulate stent haemodynamics, fibrin deposition and thrombomodulin expression. J R Soc Interface. 2014;11:20131079 pubmed publisher
    ..When endothelium was present, peristrut expression of anticoagulant thrombomodulin (TM) was dependent on strut height and geometry...
  48. Lee C, Kong M. An interactive association of common sequence variants in the neuropeptide Y gene with susceptibility to ischemic stroke. Stroke. 2007;38:2663-9 pubmed
    ..This remarkable haplotypic association suggested that the interaction between the 2 common sequence polymorphisms in NPY contributed to a great amount of phenotypic variability of ischemic stroke. ..
  49. Ikezoe T, Yang J, Nishioka C, Honda G, Furihata M, Yokoyama A. Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling. Arterioscler Thromb Vasc Biol. 2012;32:2259-70 pubmed publisher
    We have recently reported that recombinant human soluble thrombomodulin (rTM) counteracted capillary leakage associated with engraftment, as well as sinusoidal obstructive syndrome after hematopoietic stem cell transplantation...
  50. de Wit N, Rijntjes J, Diepstra J, van Kuppevelt T, Weidle U, Ruiter D, et al. Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays. Br J Cancer. 2005;92:2249-61 pubmed
    ..The genes that we identified to be differentially expressed during melanoma progression could be potent targets for diagnostic, prognostic and/or therapeutic interventions. ..
  51. Hagag A, Abdel Lateef A, Aly R. Prognostic value of plasma levels of thrombomodulin and von Willebrand factor in Egyptian children with acute lymphoblastic leukemia. J Oncol Pharm Pract. 2014;20:356-61 pubmed publisher
    ..b>Thrombomodulin is a membrane glycoprotein in the vascular endothelium...
  52. Arellano A, Bezemer I, Tong C, Catanese J, Devlin J, Reitsma P, et al. Gene variants associated with venous thrombosis: confirmation in the MEGA study. J Thromb Haemost. 2010;8:1132-4 pubmed publisher
  53. Gong J, Xie Y, Dou F, Kang L, Cheng Z. Correlation of thrombomodulin expression and occlusion of the uterine artery for the treatment of leiomyoma. Eur J Obstet Gynecol Reprod Biol. 2011;154:192-5 pubmed publisher
    To determine the difference in thrombomodulin expression in the myometrium and in myoma; and to understand the correlation of anticoagulation/fibrinolytic function and the mechanism of uterine artery occlusion in the treatment of ..
  54. Pathak R, Shao L, Chafekar S, Feng W, Ponnappan U, Fink L, et al. IKK? regulates endothelial thrombomodulin in a Klf2-dependent manner. J Thromb Haemost. 2014;12:1533-1544 pubmed publisher
    Endothelial thrombomodulin (TM) is critically involved in anticoagulation, anti-inflammation, cytoprotection and normal fetal development. Tumor necrosis factor alpha (TNF?) suppresses TM expression...
  55. Budzyń M, Gryszczyńska B, Majewski W, Krasiński Z, Kasprzak M, Formanowicz D, et al. The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm. Biomed Res Int. 2017;2017:2791082 pubmed publisher
    i>Background. The aim of the present study was to evaluate the concentration of serum thrombomodulin (sTM) in the AAA patients and to examine its correlation with various factors which may potentially participate in the endothelial ..
  56. Dudek A, Pennell C, Decker T, Young T, Key N, Slungaard A. Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C. J Biol Chem. 1997;272:31785-92 pubmed
    ..b>thrombomodulin complex by increasing its affinity for protein C 30-fold...
  57. Dargaud Y, Simpson H, Chevalier Y, Scoazec J, Hot A, Guyen O, et al. The potential role of synovial thrombomodulin in the pathophysiology of joint bleeds in haemophilia. Haemophilia. 2012;18:818-23 pubmed publisher
    ..The objective of this project was to study the potential effect of synovium-derived thrombomodulin (TM) on the pathophysiology of haemarthroses...
  58. Ikezoe T, Ikenoue N, Uchikawa N, Kojima S, Fukaya T, Yokoyama A. Use of recombinant human soluble thrombomodulin in the management of HELLP syndrome complicated by DIC. Thromb Res. 2010;126:e238-40 pubmed publisher
  59. Jourdy Y, Enjolras N, Le Quellec S, Bordet J, Negrier C, Vinciguerra C, et al. Why patients with THBD c.1611C>A (p.Cys537X) nonsense mutation have high levels of soluble thrombomodulin?. PLoS ONE. 2017;12:e0188213 pubmed publisher
    ..has described a new autosomal dominant bleeding disorder characterized by very high plasma levels of soluble thrombomodulin (TM). The THBD c.1611C>A (p.Cys537X) mutation in heterozygous state was found in the propositus...
  60. Silvin A, Yu C, Lahaye X, Imperatore F, Brault J, Cardinaud S, et al. Constitutive resistance to viral infection in human CD141+ dendritic cells. Sci Immunol. 2017;2: pubmed publisher
    ..By analyzing the susceptibility of primary human DC subsets to viral infections, we report that CD141+ DCs have an innate resistance to infection by a broad range of enveloped viruses, including HIV and ..
  61. Gerlitz B, Hassell T, Vlahos C, Parkinson J, Bang N, Grinnell B. Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474. Biochem J. 1993;295 ( Pt 1):131-40 pubmed
    b>Thrombomodulin (TM) is an endothelial cell thrombin receptor that converts thrombin from a procoagulant to an anticoagulant enzyme...
  62. Granot T, Senda T, Carpenter D, Matsuoka N, Weiner J, Gordon C, et al. Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life. Immunity. 2017;46:504-515 pubmed publisher
    ..The distribution of cDC1 (CD141hiCD13hi) and cDC2 (Sirp-α+CD1c+) subsets was a function of tissue ..
  63. Stroncek J, Xue Y, Haque N, Lawson J, Reichert W. In vitro functional testing of endothelial progenitor cells that overexpress thrombomodulin. Tissue Eng Part A. 2011;17:2091-100 pubmed publisher
    ..the augmentation of endothelial progenitor cell (EPC) thromboresistance by using gene therapy to overexpress thrombomodulin (TM), an endothelial cell membrane glycoprotein that has potent anti-coagulant properties...
  64. Minoda Y, Virshup I, Leal Rojas I, Haigh O, Wong Y, Miles J, et al. Human CD141+ Dendritic Cell and CD1c+ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo. Front Immunol. 2017;8:1419 pubmed publisher
    ..The likely human equivalents are CD141+ DC and CD1c+ DC subsets for mouse cDC1 and cDC2, respectively, but the extent of any ..
  65. Alioglu B, Kilic N, Simsek E, Dallar Y. Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor and thrombomodulin levels in children with hypothyroidism. J Clin Res Pediatr Endocrinol. 2012;4:146-50 pubmed publisher
    ..PAI) and thrombin-activatable fibrinolysis inhibitor (TAFI), tissue factor pathway inhibitor (TFPI), thrombomodulin (TM), and tissue plasminogen activator (tPA) levels in children with hypothyroidism...
  66. Rochfort K, Cummins P. Thrombomodulin regulation in human brain microvascular endothelial cells in vitro: role of cytokines and shear stress. Microvasc Res. 2015;97:1-5 pubmed publisher
    b>Thrombomodulin (TM), an important determinant of blood vessel homeostasis, is expressed on the luminal vascular endothelial cell surface and is released into serum in response to circulatory signals...
  67. Tanaka J, Seki Y, Ishikura H, Tsubota M, Sekiguchi F, Yamaguchi K, et al. Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats. Br J Pharmacol. 2013;170:1233-41 pubmed publisher
    ..Recombinant human soluble thrombomodulin (rhsTM), a medicine for treatment of disseminated intravascular coagulation (DIC), sequesters HMGB1 and ..
  68. Ahmad A, Sundquist K, Zöller B, Svensson P, Sundquist J, Memon A. Thrombomodulin gene c.1418C>T polymorphism and risk of recurrent venous thromboembolism. J Thromb Thrombolysis. 2016;42:135-41 pubmed publisher
    b>Thrombomodulin gene (THBD) is a critical cofactor in protein C anticoagulant system. THBD c...
  69. Hrabal R, Komives E, Ni F. Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin. Protein Sci. 1996;5:195-203 pubmed
    The thrombin-bound structures of native peptide fragments from the fifth EGF-like domain of thrombomodulin were determined by use of NMR and transferred NOE spectroscopy...
  70. Kuryliszyn Moskal A, Klimiuk P, Ciolkiewicz M, Sierakowski S. Clinical significance of selected endothelial activation markers in patients with systemic lupus erythematosus. J Rheumatol. 2008;35:1307-13 pubmed
    ..Serum levels of endothelin-1 (ET-1), soluble E-selectin, and thrombomodulin (sTM) were determined by ELISA in 76 SLE patients and in 34 healthy controls...
  71. Kashiwadate T, Miyagi S, Hara Y, Akamatsu Y, Kawagishi N, Sekiguchi S, et al. Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors. Transplant Proc. 2012;44:369-72 pubmed publisher
    ..were subjected to warm ischemia for 30 minutes after cardiac arrest); and (3) the recombinant human soluble thrombomodulin (ART-123) group, whose livers were retrieved in the same manner as the NHB group but pretreated with ART-123 (..
  72. Sayed S, Cockerill G, Torsney E, Poston R, Thompson M, Loftus I. Elevated tissue expression of thrombomodulatory factors correlates with acute symptomatic carotid plaque phenotype. Eur J Vasc Endovasc Surg. 2009;38:20-5 pubmed publisher
    ..u-PA), plasminogen activator inhibitor-1 (PAI-1), tissue factor (TF), tissue factor pathway inhibitor (TFPI), thrombomodulin (TM), CD68 and vascular endothelial-cadherin (VE-Cadherin)...
  73. Nakamura K, Hatano E, Miyagawa Hayashino A, Okuno M, Koyama Y, Narita M, et al. Soluble thrombomodulin attenuates sinusoidal obstruction syndrome in rat through suppression of high mobility group box 1. Liver Int. 2014;34:1473-87 pubmed publisher
    ..The aim of this study was to investigate the effects of recombinant human soluble thrombomodulin (rTM) in a monocrotaline (MCT)-induced SOS model in rats...