thrombomodulin

Summary

Gene Symbol: thrombomodulin
Description: thrombomodulin
Alias: AHUS6, BDCA3, CD141, THPH12, THRM, CD141 antigen, fetomodulin
Species: human

Top Publications

  1. doi FcεRI levels and frequencies of peripheral blood dendritic cell populations in allergic rhinitis
    Kristina Lundberg
    Department of Immunotechnology, Lund University, Lund, Sweden
    Hum Immunol 71:931-3. 2010
  2. pmc Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
    Sarah L Jongbloed
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 207:1247-60. 2010
  3. doi Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humans
    Patrick Autissier
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Cytometry A 77:410-9. 2010
  4. doi Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication
    Takeshi Nakajima
    Carcinogenesis Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Gastroenterol 45:37-44. 2010
  5. pmc An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform
    Jyh Chiang E Wang
    Human Immunology Center, David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol Methods 341:106-16. 2009
  6. pmc Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells
    Lionel Franz Poulin
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    J Exp Med 207:1261-71. 2010
  7. pmc Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism
    Linda Nocchi
    Department of Biochemistry, Biology, and Genetics, Polytechnic University of Marche, Ancona, Italy
    J Biol Chem 286:19478-88. 2011
  8. ncbi Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease
    K K Wu
    Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Circulation 103:1386-9. 2001
  9. ncbi Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM pro
    Hidemi Ishii
    Department of Public Health, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Blood 101:4765-74. 2003
  10. ncbi A common thrombomodulin amino acid dimorphism is associated with myocardial infarction
    L Norlund
    Department of Laboratory Medicine, University of Lund, University Hospital, Sweden
    Thromb Haemost 77:248-51. 1997

Detail Information

Publications153 found, 100 shown here

  1. doi FcεRI levels and frequencies of peripheral blood dendritic cell populations in allergic rhinitis
    Kristina Lundberg
    Department of Immunotechnology, Lund University, Lund, Sweden
    Hum Immunol 71:931-3. 2010
    ..In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses...
  2. pmc Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
    Sarah L Jongbloed
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 207:1247-60. 2010
    ..We report the first detailed functional analysis of the human CD141+ DC subset...
  3. doi Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humans
    Patrick Autissier
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Cytometry A 77:410-9. 2010
    ..cells, CD123+ plasmacytoid DC, and three subsets of CD11c+ myeloid DC expressing either CD16, CD1c (BDCA-1), or CD141 (BDCA-3)...
  4. doi Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication
    Takeshi Nakajima
    Carcinogenesis Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Gastroenterol 45:37-44. 2010
    ..We aimed to demonstrate the decrease in methylation levels...
  5. pmc An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform
    Jyh Chiang E Wang
    Human Immunology Center, David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol Methods 341:106-16. 2009
    ..with analysis of activation status and endocytic ability of three major PBDC subsets (CD1c(+)CD11c(+) "MDC1," CD141(+)CD11c(+) "MDC2," and CD303(+)CD11c(-) "PDC") within a single platform...
  6. pmc Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells
    Lionel Franz Poulin
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    J Exp Med 207:1261-71. 2010
    ..Here, we characterize a population of human DCs that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function...
  7. pmc Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism
    Linda Nocchi
    Department of Biochemistry, Biology, and Genetics, Polytechnic University of Marche, Ancona, Italy
    J Biol Chem 286:19478-88. 2011
    Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process...
  8. ncbi Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease
    K K Wu
    Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Circulation 103:1386-9. 2001
    b>Thrombomodulin (TM) is expressed on the endothelial surface and plays an important role in vasoprotection...
  9. ncbi Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM pro
    Hidemi Ishii
    Department of Public Health, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Blood 101:4765-74. 2003
    The present work investigated the mechanism for down-regulation of thrombomodulin (TM), an anticoagulant glycoprotein, on cultured umbilical vein endothelial cells (HUVECs) exposed to lipid extracts from oxidized low-density lipoprotein (..
  10. ncbi A common thrombomodulin amino acid dimorphism is associated with myocardial infarction
    L Norlund
    Department of Laboratory Medicine, University of Lund, University Hospital, Sweden
    Thromb Haemost 77:248-51. 1997
    ..b>Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C ..
  11. pmc Thrombomodulin is present in human plasma and urine
    H Ishii
    J Clin Invest 76:2178-81. 1985
    b>Thrombomodulin is an endothelial cell membrane protein that is a cofactor required for the rapid activation of plasma protein C...
  12. doi Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro
    Ling Yuh Shyu
    Institute of Medicine, Chung Shan Medical University, Taiwan, ROC
    Thromb Res 129:43-9. 2012
    ..In this study, we investigated the potential role of MIF in coagulation through its influence on two factors, thrombomodulin (TM) and intercellular adhesion molecule-1 (ICAM-1)...
  13. ncbi Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin
    Likui Yang
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 278:37465-70. 2003
    b>Thrombomodulin (TM), or its epidermal growth factor-like domains 456 (TM456), enhances the catalytic efficiency of thrombin toward both protein C and protein C inhibitor (PCI) by 2-3 orders of magnitude...
  14. pmc RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
    Chiu Hung Yeh
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:3812-22. 2008
    ..b>Thrombomodulin (TM) is a critical factor to activate protein C in mediating the anticoagulation and anti-inflammation effects...
  15. ncbi Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect
    Marie Christine Bouton
    Unité INSERM U698, CHU Xavier Bichat, Paris, France
    Circ Res 100:1174-81. 2007
    The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation...
  16. ncbi C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells
    Bicheng Nan
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Surgery 138:212-22. 2005
    ..The objective of the present study was to determine the effect of CRP on the expression of thrombomodulin (TM) and the endothelial protein C receptor (EPCR) in human endothelial cells.
  17. ncbi Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up study
    K Auro
    Department of Molecular Medicine, KTL, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 26:942-7. 2006
    b>Thrombomodulin is an anticoagulant expressed during endothelial activation and damage...
  18. ncbi Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface
    C T Esmon
    Oklahoma Medical Research Foundation, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    FASEB J 9:946-55. 1995
    ..The pathway is initiated when thrombin binds to the endothelial cell thrombin binding protein, thrombomodulin. The complex exhibits dramatically altered macromolecular specificity...
  19. ncbi Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function
    Gabriella Kunz
    Department of Haematology, Imperial College School of Medicine, London, United Kingdom
    Blood 99:3646-53. 2002
    Sporadic mutations in the thrombomodulin (TM) gene occur in patients with both arterial and venous thrombosis, but the effects of these mutations on expression and function are largely unexplored...
  20. ncbi Variations in the thrombomodulin and endothelial protein C receptor genes in couples with recurrent miscarriage
    M Kaare
    Folkhalsan Institute of Genetics, University of Helsinki, Finland
    Hum Reprod 22:864-8. 2007
    ..Loss of function of two of these genes, thrombomodulin (TM) and endothelial protein C receptor (EPCR), causes embryonic lethality in mice...
  21. ncbi Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation
    Marlies Van de Wouwer
    The Center for Transgene Technology and Gene Therapy, University of Leuven and the Flanders Interuniversity Institute for Biotechnology VIB, Belgium
    Arterioscler Thromb Vasc Biol 24:1374-83. 2004
    ..Most of these can be traced to the vasculature, where the systems most intimately interact. Thrombomodulin (TM), a cell surface-expressed glycoprotein, predominantly synthesized by vascular endothelial cells, is a ..
  22. ncbi Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE Study
    N Aleksic
    Division of Hematology, University of Texas Medical School, Houston, TX 77030, USA
    J Thromb Haemost 1:88-94. 2003
    Plasma thrombomodulin (soluble TM; sTM) is considered to be a marker of endothelial injury, but a recent report indicated that the relationship of sTM with thrombosis is complex...
  23. ncbi Expression of calretinin, thrombomodulin, keratin 5, and mesothelin in lung carcinomas of different types: an immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleura
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 27:150-8. 2003
    Several immunohistochemical markers, among them calretinin, thrombomodulin (CD141), keratin 5, and mesothelin, have been documented or suggested as useful markers for positive identification of mesothelioma and to differentiate it from ..
  24. pmc Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin
    Rashmi Sood
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Blood 112:585-91. 2008
    Absence of the blood coagulation inhibitor thrombomodulin (Thbd) from trophoblast cells of the mouse placenta causes a fatal arrest of placental morphogenesis...
  25. ncbi The thrombomodulin-protein C system is essential for the maintenance of pregnancy
    Berend Isermann
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA
    Nat Med 9:331-7. 2003
    Disruption of the mouse gene encoding the blood coagulation inhibitor thrombomodulin (Thbd) leads to embryonic lethality caused by an unknown defect in the placenta...
  26. pmc Vascular density and phenotype around ductal carcinoma in situ (DCIS) of the breast
    N B Teo
    Pathology Department, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Cancer 86:905-11. 2002
    ..were determined using morphometry and a panel of anti-endothelial antibodies (von Willebrand factor, CD31, CD141 and CD34) and related to the presence of invasive carcinoma and other histological features...
  27. doi Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome
    Tara K Maga
    Interdepartmental PhD Program in Genetics, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Mutat 31:E1445-60. 2010
    ..5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD). Since aHUS is rare, mutation rate data in large patient cohorts are scarce...
  28. ncbi Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source
    Dorthe Schmidt
    Clinic for Cardiovascular Surgery and Department of Surgical Research, University and University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Circulation 116:I64-70. 2007
    ..A novel concept providing prenatally tissue engineered human autologous heart valves based on routinely obtained fetal amniotic fluid progenitors as single cell source is introduced...
  29. doi Peritubular capillary loss is ameliorated by ramipril or valsartan treatment
    Bin Zhang
    Department of Nephrology, Guangdong Provincial People s Hospital, Nanfang Medical University, Guangzhou, China
    Microcirculation 15:337-48. 2008
    ..To identify the preservation of peritubular capillaries conferred by ramipril or valsartan treatment as an additional mechanism for their renoprotection...
  30. doi Three DNA methylation epigenotypes in human colorectal cancer
    Koichi Yagi
    Genome Science Division, Department of Gastrointestinal Surgery, Research Center for Advanced Science and Technology, Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 16:21-33. 2010
    ..Our aim is to clarify DNA methylation epigenotypes of colorectal cancer more comprehensively...
  31. ncbi Cryopreserved amniotic fluid-derived cells: a lifelong autologous fetal stem cell source for heart valve tissue engineering
    Dorthe Schmidt
    Clinic for Cardiovascular Surgery, Department of Surgical Research, University, University Hospital, Zurich, Switzerland
    J Heart Valve Dis 17:446-55; discussion 455. 2008
    ..In order to expand the versatility of these cells also for adult application, cryopreserved AFDC were investigated as a potential life-long available cell source for heart valve tissue engineering...
  32. pmc Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo
    Dawn K Coletta
    Division of Diabetes, Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA
    Am J Physiol Endocrinol Metab 294:E910-7. 2008
    ..The results of the present study demonstrate that insulin acutely regulates the levels of mRNAs involved in inflammation and transcription and identifies several candidate genes, including HES1 and BHLHB2, for further investigation...
  33. ncbi Surface antigens of human mesangial cells: impact of growth surface or IL-1alpha
    G Sengoelge
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Wien, Austria
    Tissue Antigens 60:383-95. 2002
    ..58, 90, 106, 146, 147, 166; growth factor receptors: CD105, 140b; apoptosis related: CD95; hemostatis related: CD141, 142; miscellaneous: CD44, 109, 138, 151, 157, 165, and 11 nonclustered antigens) reacted with mesangial cells...
  34. ncbi Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense
    Y D Dean
    Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, GB
    Eur J Immunol 31:1370-81. 2001
    Phagocytic complement C1q receptor (C1qRp) and thrombomodulin (TM, CD141), are two key members of a novel family of lectin receptors involved in cell-cell interactions and innate immune host defense...
  35. ncbi Microarray analysis of the effect of diesel exhaust particles on in vitro cultured macrophages
    Geert R Verheyen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, B 2400 Mol, Belgium
    Toxicol In Vitro 18:377-91. 2004
    ..Our data indicate the multitude of biological processes potentially influenced by DEP...
  36. ncbi Phenotypic differences between red pulp capillary and sinusoidal endothelia help localizing the open splenic circulation in humans
    Birte Steiniger
    Institute of Anatomy and Cell Biology, University of Marburg, Robert Koch Str 8, 35032, Marburg, Germany
    Histochem Cell Biol 128:391-8. 2007
    ..Double staining for CD34 and CD141 (thrombomodulin) revealed that capillary endothelia in the cords of the splenic red pulp and at the surface of follicles were ..
  37. ncbi Twelve loci from HSA10, HSA11 and HSA20 were comparatively FISH-mapped on river buffalo and sheep chromosomes
    L Iannuzzi
    National Research Council CNR, IABBAM, Laboratory of Animal Cytogenetics, Via Argine 1085, 80147 Naples Ponticelli, Italy
    Cytogenet Cell Genet 93:124-6. 2001
    ..Indirect comparisons between physical maps achieved on bovid chromosomes and those reported on HSA10, HSA11 and HSA20 were performed...
  38. ncbi VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung
    A M Healy
    The Pulmonary Center, Boston University School of Medicine, Boston Massachusetts 02118, USA
    Dev Dyn 219:341-52. 2000
    ..Platelet endothelial cell adhesion molecule-1 (PECAM/CD31) and thrombomodulin (TM/CD141) immunolocalization demonstrate that vascular development occurs in lung cultures...
  39. doi Genetic aspects of ischemic stroke: coagulation, homocysteine, and lipoprotein metabolism as potential risk factors
    Sanja Stankovic
    Institute for Medical Biochemistry, University School of Pharmacy and Clinical Center of Serbia, Belgrade, Serbia
    Crit Rev Clin Lab Sci 47:72-123. 2010
    ..The data assembled could be very useful for further meta-analysis and for future clinical applications...
  40. ncbi [Chiparray-based identification of gene expression in HUVECs treated with low frequency electric fields]
    D Ulrich
    Klinik für Plastische Chirurgie, Hand und Verbrennungschirurgie, Universitatsklinikum Aachen, Germany
    Handchir Mikrochir Plast Chir 38:149-55. 2006
    ..In this study, we report on IN VITRO studies performed to characterize gene expression profiles using a DNA-microarray in HUVECs (human umbilical vein endothelial cells) exposed to low frequency electrical current...
  41. doi Isolation of human blood DC subtypes
    Andrew J Kassianos
    Mater Medical Research Institute, South Brisbane, QLD, Australia
    Methods Mol Biol 595:45-54. 2010
    ..CD11c(+) myeloid DC, which can be further subdivided into three subsets based on differential expression of CD1c, CD141 and CD16...
  42. doi Screening of the HLDA9 panel on peripheral blood dendritic cell populations
    Yitian Ding
    Mater Medical Research Institute, Aubigny Place, South Brisbane, Queensland, Australia
    Immunol Lett 134:161-6. 2011
    ..The CD11c(+) myeloid DC can be divided into populations by CD1c, CD16 and CD141 expression...
  43. doi Assessment of physiological amplitude, duration, and magnitude of ECG T-wave alternans
    Laura Burattini
    Department of Biomedical, Electronics, and Telecommunication Engineering, Polytechnic University of Marche, 60131 Ancona, Italy
    Ann Noninvasive Electrocardiol 14:366-74. 2009
    ....
  44. ncbi Cytogenetic alignment of the bovine chromosome 13 genome map by fluorescence in-situ hybridization of human chromosome 10 and 20 comparative markers
    D S Gallagher
    Department of Animal Science, Texas A and M University, College Station 77843, USA
    Chromosome Res 7:115-9. 1999
    ..These FISH results anchor the BTA13 genome map from bands 14-23, and confirm the presence of a conserved HSA10 homologous synteny group on BTA13 centromeric to a HSA20 homologous segment...
  45. ncbi Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors
    Jennifer Brady
    Brain Inflammation and Immunity Group, Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    J Neuropathol Exp Neurol 63:1274-83. 2004
    ..Its protein domain architecture is homologous to that of CD93 and thrombomodulin (CD141), suggesting a similar function in mediating cell-cell interactions...
  46. ncbi Mouse models of thrombosis: thrombomodulin
    Hartmut Weiler
    Blood Research Institute, Blood Center of Southeastern Wisconsin, Medical College of Wisconsin, Department of Physiology, 8727 Watertown Plank Road, Milwaukee, WI 53226, USA
    Thromb Haemost 92:467-77. 2004
    This review describes animal models of TM-deficiency that cause thrombosis in mice. Thrombomodulin (TM) is a key component of the protein C anticoagulant pathway by facilitating the activation of protein C by thrombin...
  47. doi Expression of blood dendritic cell antigens (BDCAs) by CD1a+ human pulmonary cells
    Maria Tsoumakidou
    Lung Pathology Unit, London SW3 6LY, UK
    Respir Med 103:935-8. 2009
    ..We investigated the expression of these antigens by isolated human pulmonary CD1a(+) DCs, namely Langerhan's cells...
  48. pmc IL-32-dependent effects of IL-1beta on endothelial cell functions
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 106:3883-8. 2009
    ..In contrast, the anti-inflammatory/anti-coagulant CD141/thrombomodulin increased markedly when IL-32 was silenced...
  49. doi Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease
    Andrew J Kassianos
    Conjoint Kidney Research Laboratory, Pathology Queensland, Queensland Institute of Medical Research, Level 9, Bancroft Centre, Herston 4006, Queensland, Australia
    Am J Physiol Renal Physiol 305:F1391-401. 2013
    ..We detected significantly greater numbers of total DCs as well as CD141(hi) and CD1c(+) myeloid DC (mDCs) subsets in diseased biopsies with interstitial fibrosis than diseased biopsies ..
  50. doi The association of idiopathic recurrent pregnancy loss with polymorphisms in hemostasis-related genes
    Yunlei Cao
    Fudan University, 130 Dong an Road, Shanghai 200032, China NPFPC Laboratory of Contraception and Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, China
    Gene 530:248-52. 2013
    ..study were to investigate the effects of polymorphisms in hemostasis-related genes antithrombin (SERPINC1), thrombomodulin (THBD), tissue factor pathway inhibitor (TFPI), factor V, factor II and annexin A5 (ANXA5), involved in ..
  51. doi Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis risk
    Silvia Navarro
    Unidad de Bioquimica, Centro de Investigacion, Hospital Universitario La Fe, Valencia, Spain
    Arterioscler Thromb Vasc Biol 33:1435-40. 2013
    ..1418C>T polymorphism, which encodes for the replacement of Ala455 by Val in thrombomodulin (TM), with venous thromboembolism (VTE), plasma soluble TM, and activated protein C levels...
  52. pmc Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation
    Carsten Carlberg
    School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 8:e71042. 2013
    ..The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for ..
  53. pmc Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C
    Likui Yang
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 103:879-84. 2006
    ..The binding of Ca(2+) to the 70-80 loop of protein C inhibits protein C activation by thrombin in the absence of thrombomodulin (TM), but the metal ion is required for activation in the presence of TM...
  54. doi Impaired binding of thrombin to thrombomodulin is associated with risk of deep vein thrombosis
    Etsuji Suehisa
    Laboratory for Clinical Investigation, Osaka University Hospital, Suita City, Osaka, Japan
    Thromb Res 123:85-92. 2008
    The complex of thrombin and thrombomodulin (TM) activates protein C, and impaired binding of thrombin to TM may be a risk factor for thrombosis...
  55. doi Thrombomodulin gene polymorphisms in brain infarction and mortality after stroke
    Jean Marc Olivot
    INSERM U698 and Denis Diderot University Paris VII, Dept of Neurology and Stroke Center, Bichat University Hospital, Paris, France
    J Neurol 255:514-9. 2008
    b>Thrombomodulin is expressed at the surface of endothelial cells and controls thrombin generation and thrombin-induced platelets and vascular cell activation...
  56. doi Ets-1 mediates platelet-derived growth factor-BB-induced thrombomodulin expression in human vascular smooth muscle cells
    I Chung Lo
    Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan, Republic of China
    Cardiovasc Res 81:771-9. 2009
    b>Thrombomodulin (TM), a potent anticoagulant, is not detected in quiescent vascular smooth muscle cells (VSMCs). In diseased vessels, VSMC expresses TM, but the mechanisms are unclear...
  57. doi The fate of renal allografts hinges on responses of the microvascular endothelium
    Venkat K R Mannam
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA
    Exp Mol Pathol 94:398-411. 2013
    ..were positive for HLA-ABC, HLA-DR/DQ, von Willebrand factor, endoglin, PECAM, ICAM, MCAM, integrin beta-3, thrombomodulin, E-selectin, VCAM-1, and tissue factor, and negative for alpha smooth muscle actin and P-selectin antibodies...
  58. ncbi [Effect of C5a on expression of thrombomodulin in endothelial cells in vitro]
    Wei Fang
    Guangzhou Medical College, Guangzhou 510010, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:168-71. 2009
    To investigate the effect of C5a on the expression of thrombomodulin (TM) in human umbilical vein endothelial cells (HUVECs).
  59. pmc Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity
    Hartmut Geiger
    Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Med 18:1123-9. 2012
    ..Here we identify the thrombomodulin (Thbd)-activated protein C (aPC) pathway as a new mechanism for the mitigation of total body irradiation (TBI)-..
  60. ncbi Genetic risk for restenosis after coronary balloon angioplasty
    Hideki Horibe
    Department of Cardiology, Kosei Hospital, Anjo, Japan
    Atherosclerosis 174:181-7. 2004
    ..two polymorphisms (242C --> T in the NADH/NADPH oxidase p22 phox (p22-PHOX) gene and 2136C --> T in the thrombomodulin (THBD) gene) in men and two polymorphisms (584G --> A in the paraoxonase 1 (PON1) gene and 2445G --> A ..
  61. pmc The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?
    B Steiniger
    Institute of Anatomy and Cell Biology, University of Marburg, Robert Koch Str 6, D 35033 Marburg, Germany
    Am J Pathol 159:501-12. 2001
    ..and VAP-1; the Thy-1 (CD90) molecule; smooth muscle alpha-actin and smooth muscle myosin; cytokeratin 18; and thrombomodulin (CD141)...
  62. ncbi Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p)
    D R Maglott
    American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852 1776, USA
    Mamm Genome 7:400-1. 1996
  63. pmc Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC
    Henning Lauterbach
    Department of Research Immunology, Bavarian Nordic GmbH, 82152 Martinsried, Germany
    J Exp Med 207:2703-17. 2010
    ..Human DCs expressing BDCA3 (CD141), which is considered to be the human counterpart of murine CD8α(+) DCs, also produced large amounts of IFN-λ ..
  64. pmc Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin
    Laurent O Mosnier
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:502-10. 2011
    b>Thrombomodulin (TM) is a cofactor for thrombin-mediated activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI) and thereby helps coordinate coagulation, anticoagulation, fibrinolysis, and inflammation...
  65. doi Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status
    Diana Mittag
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 186:6207-17. 2011
    ..We identify three conventional DC subsets characterized by surface expression of CD1b/c, CD141, and CD16, and one plasmacytoid DC subset characterized by CD304 expression...
  66. ncbi Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    Berend Isermann
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Nat Med 13:1349-58. 2007
    ..Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally linked to nephropathy...
  67. doi Thrombomodulin and its role in inflammation
    Edward M Conway
    Division of Hematology Oncology, Department of Medicine, Centre for Blood Research CBR, University of British Columbia, Vancouver, BC, Canada
    Semin Immunopathol 34:107-25. 2012
    The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data were collected from published research...
  68. doi Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells
    K M Silk
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Gene Ther 19:1035-40. 2012
    ..Unlike moDC, a subset of ipDC was found to coexpress CD141 and XCR1 that have been shown previously to define the human equivalent of mouse CD8α(+) DC, in which the ..
  69. ncbi Thrombomodulin links coagulation to inflammation and immunity
    John Morser
    Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, MC5156, Stanford, CA 9435 5156, USA
    Curr Drug Targets 13:421-31. 2012
    b>Thrombomodulin (TM) is a type 1 membrane bound glycoprotein that has a C-type lectin domain at its Nterminus, 6 copies of the epidermal growth factor-like (EGF) motif and serine/threonine rich domain carrying a glycosoaminoglycan external ..
  70. doi Best immunohistochemical panel in distinguishing adenocarcinoma from squamous cell carcinoma of lung: tissue microarray assay in resected lung cancer specimens
    Mi Jin Kim
    Department of Pathology, Yeungnam University College of Medicine, Nam Gu, Daegu, South Korea
    Ann Diagn Pathol 17:85-90. 2013
    ..using tissue microarray for napsin-A, Thyroid transcription factor 1 (TTF-1), p63, cytokeratin (CK) 5/6, thrombomodulin (CD141), Epithelial-related antigen (MOC-31), carcinoembryonic antigen (CEA), Cyclooxygenase 2 (COX-2), high-..
  71. doi Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Arterioscler Thromb Vasc Biol 32:2259-70. 2012
    We have recently reported that recombinant human soluble thrombomodulin (rTM) counteracted capillary leakage associated with engraftment, as well as sinusoidal obstructive syndrome after hematopoietic stem cell transplantation...
  72. doi Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli
    Andrew J Kassianos
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Eur J Immunol 42:1512-22. 2012
    Human blood myeloid DCs can be subdivided into CD1c (BDCA-1)(+) and CD141 (BDCA-3)(+) subsets that display unique gene expression profiles, suggesting specialized functions...
  73. ncbi Professional Cross-Presenting CD8α-Type CD141(hi) Dendritic Cells: We Have Got You in Our Skin!
    Marc Dalod
    Centre d immunologie de Marseille Luminy, Aix Marseille Université UM2, Campus de Luminy case 906, 13288 Marseille, France INSERM, UMR1104, 13288 Marseille, France CNRS, UMR7280, 13288 Marseille, France
    Immunity 37:3-5. 2012
    ..2012) identify the presence of professional cross-presenting human dendritic cells in the skin, the liver, and the lung and also presented comparative genomics to align human and mouse dendritic cell types across tissues...
  74. doi Naturally occurring CD1c+ human regulatory dendritic cells: immunoregulators that are expanded in response to E. coli infection
    Cheng Qian
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, China
    Eur J Immunol 42:1388-92. 2012
    ..Initial studies of DCs in human blood revealed that steady-state myeloid DCs are comprised of the CD141(+) and CD1c(+) DC subsets as the equivalents to the mouse lymphoid resident CD8(+) and CD8(-) DC subsets, ..
  75. pmc Atypical hemolytic uremic syndrome in children: complement mutations and clinical characteristics
    Lianne M Geerdink
    Department of Pediatric Nephrology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Pediatr Nephrol 27:1283-91. 2012
    Mutations in complement factor H (CFH), factor I (CFI), factor B (CFB), thrombomodulin (THBD), C3 and membrane cofactor protein (MCP), and autoantibodies against factor H (αFH) with or without a homozygous deletion in CFH-related protein ..
  76. doi Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma
    M Spears
    Department of Respiratory Medicine, Institute of Infection, Immunity and Inflammation, Gartnavel General Hospital, University of Glasgow, Glasgow, UK
    Clin Exp Allergy 41:665-72. 2011
    ..Smokers with asthma display altered therapeutic behaviour and a reduction in endobronchial DC CD83 expression compared with non-smokers with asthma. No information is available on the impact of smoking on peripheral blood DC profiles...
  77. doi Thrombomodulin and von Willebrand factor: relation to endothelial dysfunction and disease outcome in children with acute lymphoblastic leukemia
    Emmanouel S Hatzipantelis
    Department of Paediatrics, AHEPA Hospital, Thessaloniki, Greece
    Acta Haematol 125:130-5. 2011
    ..In children with ALL, there was a significant increase in thrombomodulin (TM) and von Willebrand factor (vWF) levels during the acute phase of the disease and during treatment...
  78. doi Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis
    Cheol Min Shin
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Cancer Sci 101:1337-46. 2010
    ..pylori. Aberrant methylation of THBD might provide a link between H. pylori infection and development of GC...
  79. doi Sources of thrombomodulin in pre-eclampsia: renal dysfunction or endothelial damage?
    Luci Dusse
    Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Brazil
    Semin Thromb Hemost 37:153-7. 2011
    ..Among others, plasma thrombomodulin (TM) level rises significantly...
  80. pmc Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses
    Robert L Lobato
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Circulation 124:S143-8. 2011
    ..We tested the hypothesis that genetic variation in thrombotic and inflammatory pathways is independently associated with long-term mortality after coronary artery bypass graft (CABG) surgery...
  81. doi Transdifferentiation potentiality of human Wharton's jelly stem cells towards vascular endothelial cells
    Miguel Alaminos
    Department of Histology, University of Granada, Granada, Spain
    J Cell Physiol 223:640-7. 2010
    ..All this implies that HWJSC are able to efficiently transdifferentiate towards Tr-ELC at the phenotypical level following a hierarchical pattern of gene activation, with an earlier induction of morphological and phenotypical genes...
  82. doi JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter
    Yuanyuan Rong
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong, China
    FEBS Lett 584:852-8. 2010
    b>Thrombomodulin (TM) is an important vascular protective molecule that has anticoagulant, anti-inflammatory and anti-apoptotic properties. TM is downregulated in many thrombotic and vascular diseases...
  83. pmc Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells
    Annabell Bachem
    Molecular Immunology, Robert Koch Institute, 13353 Berlin, Germany
    J Exp Med 207:1273-81. 2010
    ..into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets...
  84. doi Thrombomodulin and GFC levels in Legg-Calve-Perthes disease
    M Cemalettin Aksoy
    Department of Orthopedics and Traumatology, Hacettepe University Medical School, 06100 Sihhiye, Ankara, Turkey
    Hematology 13:324-8. 2008
    ..Circulating soluble thrombomodulin (TM) reflects endothelial activation and/or injury...
  85. ncbi Increased P-selectin expression on platelets and decreased plasma thrombomodulin in Fontan patients
    Hidemi Kajimoto
    Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
    Circ J 73:1705-10. 2009
    ..P-selectin on platelets indicates platelet activation. Thrombomodulin (TM), a receptor for thrombin and a major anticoagulant proteoglycan on the endothelial membrane, reflects the ..
  86. pmc Thrombomodulin mutations in atypical hemolytic-uremic syndrome
    Mieke Delvaeye
    VIB K U Leuven Vesalius Research Center, Leuven, Belgium
    N Engl J Med 361:345-57. 2009
    ..Genetic factors in the remaining cases are unknown. We studied the role of thrombomodulin, an endothelial glycoprotein with anticoagulant, antiinflammatory, and cytoprotective properties, in atypical ..
  87. pmc Valves of the deep venous system: an overlooked risk factor
    Erin G Brooks
    Department of Pathology, University of Vermont, Burlington, VT 05482, USA
    Blood 114:1276-9. 2009
    ..In pursuit of this hypothesis, we quantified endothelial protein C receptor (EPCR), thrombomodulin (TM), and von Willebrand factor (VWF) by immunofluorescence in great saphenous veins harvested at cardiac ..
  88. doi Loss of Arnt (Hif1β) in mouse epidermis triggers dermal angiogenesis, blood vessel dilation and clotting defects
    Assefa Wondimu
    Department of Dermatology, Columbia University, New York, NY, USA
    Lab Invest 92:110-24. 2012
    ....
  89. pmc aHUS caused by complement dysregulation: new therapies on the horizon
    Aoife M Waters
    Department of Nephrology, Great Ormond Street Hospital, London, WC1N 3JH, UK
    Pediatr Nephrol 26:41-57. 2011
    ..More recently, mutations have also been identified in thrombomodulin (THBD), an anticoagulant glycoprotein that plays a role in the inactivation of C3a and C5a...
  90. doi Common variants in the haemostatic gene pathway contribute to risk of early-onset myocardial infarction in the Italian population
    Ilaria Guella
    Department of Biology and Genetics for Medical Sciences, University of Milan, Milano, Italy
    Thromb Haemost 106:655-64. 2011
    ..69-fold increased risk for MI compared with those in the lowest quintile. Our results suggest that a GRS, based on the combined effect of several risk alleles in different haemostatic genes, is associated with an increased risk of MI...
  91. pmc Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition
    Yuan Chung Kao
    Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Mol Cell Biol 30:4767-85. 2010
    The expression of thrombomodulin (TM), a calcium-dependent adhesion molecule, is frequently downregulated in various cancer types. However, the mechanism responsible for the low expression level of TM in tumorigenesis is unknown...
  92. ncbi Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assays
    S Imada
    Division of Cell Biology, Meiji Institute of Health Science, Meiji Milk Products Co Ltd, Odawara, Japan
    Dev Biol 140:113-22. 1990
    ..We now show by protein and DNA sequencing and by functional assays that FM is identical to thrombomodulin, an anticoagulant endothelial thrombin receptor...
  93. ncbi A combination of two common thrombomodulin gene variants (-1208-1209TTdelTT and A455V) influence risk of coronary heart disease: a prospective study in men
    C J Konstantoulas
    British Heart Foundation Laboratories, Department of Medicine, Center for Cardiovascular Genetics, Royal Free and University College London Medical School, Rayne Building, London WC1E 6JF, UK
    Atherosclerosis 177:97-104. 2004
    ..study of myocardial infarction (MI), we identified risk associated with the combination of two variants in the thrombomodulin (TM) gene (-1208-1209TTdelTT and A455V) and an interaction with increased body mass index (BMI)...
  94. ncbi Increased levels of endothelial haemostatic markers in patients with coronary heart disease
    Anita Schumacher
    Department of Microbiology, Vestfold Central Hospital, Tønsberg, Norway
    Thromb Res 105:25-31. 2002
    von Willebrand factor (vWF), thrombomodulin and tissue plasminogen activator antigen (tPAag) are regarded as markers of endothelial activation and/or damage. Elevated levels have been associated with atherosclerotic disease states...
  95. ncbi Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain
    Huey Chun Huang
    Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan 701, Republic of China
    J Biol Chem 278:46750-9. 2003
    b>Thrombomodulin (TM) is an integral membrane glycoprotein that is a potent anticoagulant factor. TM may also possess functions distinct from its anticoagulant activity...
  96. ncbi Decrease of thrombomodulin contributes to the procoagulant state of endothelium in hemolytic uremic syndrome
    Gabriela C Fernandez
    Division Inmunologia, IIHEMA, Academia Nacional de Medicina, Buenos Aires, Argentina
    Pediatr Nephrol 18:1066-8. 2003
    ..Vascular endothelial cell (EC) injury appears to be central in the pathogenesis of D+HUS. Thrombomodulin (TM) is a glycoprotein present in EC with anti-thrombogenic properties...
  97. ncbi Circulating thrombomodulin levels are related to latent progression of atherosclerosis in hypertensive patients
    Yasuaki Dohi
    Internal Medicine and Molecular Science, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Hypertens Res 26:479-83. 2003
    The present study was designed to test the hypothesis that circulating levels of thrombomodulin are elevated in patients with hypertension in proportion to the severity of the vascular damage...
  98. ncbi Reduced thrombomodulin in human peripheral nerve microvasculature
    Charlene E Hafer-Macko
    Department of Neurology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, Maryland 21201 1595, USA
    Muscle Nerve 26:218-24. 2002
    b>Thrombomodulin (TM), a vascular endothelial receptor, terminates the actions of thrombin and accelerates activated protein C formation...
  99. ncbi Polymorphisms in various coagulation genes in black South African women with placental abruption
    B Hira
    Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    BJOG 109:574-5. 2002
    This pilot study examined Factor V Leiden (R506Q), prothrombin (20210G-->A), thrombomodulin (A455V) and MTHFR (677C-->T) in 100 Zulu-speaking black South African women with placental abruption and 217 controls...

Research Grants39

  1. INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLS
    Lloyd Mayer; Fiscal Year: 2007
    In this R-01 granting period we have identified an apoptotic protein isolated from the CD141/low CD16/high 43/HIV human macrophage hybridoma cell line...
  2. INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLS
    Kirk Sperber; Fiscal Year: 2005
    In this R-01 granting period we have identified an apoptotic protein isolated from the CD141/low CD16/high 43/HIV human macrophage hybridoma cell line...
  3. ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHY
    CHARLENE HAFER MACKO; Fiscal Year: 2002
    ..We also found that thrombomodulin (TM), an endothelial membrane receptor that deactivates thrombin and accelerates activated protein C formation ..
  4. NUTRITION ACADEMIC AWARD
    Michael Miller; Fiscal Year: 2004
    ..Compliance with ATP II and JNC VI recommendations will also be assessed. In addition, medical students' diets and blood lipid levels will be assessed and tracked. ..
  5. MOLECULAR & CLINICAL EVALUATION OF LOW HDL SYNDROMES
    Michael Miller; Fiscal Year: 2003
    ..Further understanding of the molecular basis of isolated low HDL-C and its potential clinical sequelae (e.g., CAD), may therefore aid in the development of therapeutic strategies to effectively treat this disorder. ..
  6. Genetic Reg. of Hematopoietic Stem Cell Mobilization
    Hartmut Geiger; Fiscal Year: 2007
    ..g. to muscle tissue, or to other hematopoietic niches. ..
  7. Mayo Clinic Vascular Medicine Clinical Research Training Program
    John Heit; Fiscal Year: 2007
    ..In addition, this research will teach doctors how to discover new causes of diseases of arteries, veins and lymph vessels, as well as new ways to prevent and treat these diseases. ..
  8. Direct Cellular Effects of Blood Coagulation Proteases
    LAURENT MOSNIER; Fiscal Year: 2007
    ..I propose: 1) To characterize the formation of endothelial cell membrane receptor complexes between thrombomodulin, endothelial protein C receptor and protease activated receptor-1 required for APC generation and APC's direct ..
  9. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009
    ..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..
  10. RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN THE COMMUNITY
    John A Heit; Fiscal Year: 2010
    ..This study aims to prevent these deaths by identifying the individual person at high risk and preventing venous thromboembolism. ..
  11. RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN THE COMMUNITY
    John Heit; Fiscal Year: 2007
    ..This data will provide insights regarding the effect of new prophylaxis drugs on VTE incidence and why some but not most high-risk patients develop VTE, and test the effect of outpatient LMWH therapy on VTE recurrence. ..
  12. RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN THE COMMUNITY
    John Heit; Fiscal Year: 2004
    ..Finally, the investigators will plan to extend their analysis of current VTE in relationship to use of standard heparin and low molecular weight heparin. ..
  13. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2007
    ..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..
  14. Structure-function of cytoprotective coagulation proteases and their receptors
    LAURENT OLIVIER MOSNIER; Fiscal Year: 2011
    ..associated with "off-target" Heparin-Induced Thrombocytopenia (HIT) antibodies against PF4-EPCR and PF4-thrombomodulin (TM) complexes...