Gene Symbol: THRA
Description: thyroid hormone receptor alpha
Alias: AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor alpha, EAR-7, ERBA-related 7, V-erbA-related protein 7, c-erbA-alpha, nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), thyroid normone nuclear receptor alpha variant 1, triiodothyronine receptor
Species: human
Products:     THRA

Top Publications

  1. Chan I, Privalsky M. Isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1. Mol Endocrinol. 2009;23:1758-75 pubmed publisher
  2. Martinez L, Nascimento A, Nunes F, Phillips K, Aparicio R, Dias S, et al. Gaining ligand selectivity in thyroid hormone receptors via entropy. Proc Natl Acad Sci U S A. 2009;106:20717-22 pubmed publisher
    ..Similar effects could potentially be exploited in nuclear receptor drug design. ..
  3. Sap J, Munoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, et al. The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature. 1986;324:635-40 pubmed
    ..In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the nucleus. ..
  4. DeLong L, Bonamy G, Fink E, Allison L. Nuclear export of the oncoprotein v-ErbA is mediated by acquisition of a viral nuclear export sequence. J Biol Chem. 2004;279:15356-67 pubmed
    v-ErbA, an oncogenic derivative of the thyroid hormone receptor alpha (TRalpha) carried by the avian erythroblastosis virus, contains several alterations including fusion of a portion of avian erythroblastosis virus Gag to its N terminus, ..
  5. Meulenbelt I, Bos S, Chapman K, van der Breggen R, Houwing Duistermaat J, Kremer D, et al. Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility. Ann Rheum Dis. 2011;70:164-7 pubmed publisher
    ..To elucidate the molecular mechanisms focus should be on the local adaptation to T3 availability either during the endochondral ossification process or during ageing of the articular cartilage. ..
  6. van Mullem A, Chrysis D, Eythimiadou A, Chroni E, Tsatsoulis A, de Rijke Y, et al. Clinical phenotype of a new type of thyroid hormone resistance caused by a mutation of the TR?1 receptor: consequences of LT4 treatment. J Clin Endocrinol Metab. 2013;98:3029-38 pubmed publisher
    ..These patients have low free T?, low T?, high T?, low rT?, and normal TSH serum levels, in combination with growth retardation, delayed bone development, and constipation...
  7. Moran C, Schoenmakers N, Agostini M, Schoenmakers E, Offiah A, Kydd A, et al. An adult female with resistance to thyroid hormone mediated by defective thyroid hormone receptor α. J Clin Endocrinol Metab. 2013;98:4254-61 pubmed publisher
    ..Clinical, biochemical, and radiological assessment and THRA sequencing were undertaken...
  8. Weinberger C, Thompson C, Ong E, Lebo R, Gruol D, Evans R. The c-erb-A gene encodes a thyroid hormone receptor. Nature. 1986;324:641-6 pubmed
    ..Binding studies with the protein show it to be a receptor for thyroid hormones. ..
  9. Köhrle J. Thyroid Hormones and Derivatives: Endogenous Thyroid Hormones and Their Targets. Methods Mol Biol. 2018;1801:85-104 pubmed publisher
    ..of membrane-associated, mitochondrial or nuclear thyroid hormone receptors (TR), which are members of the c-erbA family of ligand-modulated transcription factors...

More Information

Publications239 found, 100 shown here

  1. Krude H, Kühnen P, Biebermann H. Treatment of congenital thyroid dysfunction: Achievements and challenges. Best Pract Res Clin Endocrinol Metab. 2015;29:399-413 pubmed publisher
    ..Abnormalities of these mechanisms include the MCT8-transport defect, deiodinase-insufficiency and thyroid hormone receptor alpha-and beta defects...
  2. Hernandez A. Thyroid Hormone Role and Economy in the Developing Testis. Vitam Horm. 2018;106:473-500 pubmed publisher
    ..These include the thyroid hormone receptor alpha (THRA), the MCT8 transporter, the TH-activating deiodinase DIO2, and the TH-inactivating deiodinase ..
  3. Iyer P, Bolla J, Kumar V, Gill M, Sobhia M. In silico identification of targets for a novel scaffold, 2-thiazolylimino-5-benzylidin-thiazolidin-4-one. Mol Divers. 2015;19:855-70 pubmed publisher
    ..affinity against diverse targets, particularly, towards COX-2, acetylcholinesterase, aldose reductase, and thyroid hormone receptor alpha. This study describes an initial probability that these proteins may be targeted by this scaffold.
  4. Haldar R, Shaashua L, Lavon H, Lyons Y, Zmora O, Sharon E, et al. Perioperative inhibition of β-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome. Brain Behav Immun. 2018;73:294-309 pubmed publisher
    ..improvement at T2/T3 in several transcription factors that in primary tumors indicate poor prognosis (CUX1, THRa, EVI1, RORa, PBX1, and T3R), angiogenesis (YY1), EMT (GATA1 and deltaEF1/ZEB1), proliferation (GATA2), and ..
  5. Wood R, Seidel J, Martyniuk C. Transcripts involved in steroid biosynthesis and steroid receptor signaling are expressed early in development in the fathead minnow (Pimephales promelas). Comp Biochem Physiol B Biochem Mol Biol. 2015;182:64-72 pubmed publisher relative mRNA abundance over the first two weeks of development included ar, dax1, hsd11b2, hsd17b, cyp19a and thra. This study demonstrates that there is early expression of transcripts related to steroid biosynthesis, steroid ..
  6. Handkiewicz Junak D, Swierniak M, Rusinek D, Oczko Wojciechowska M, Dom G, Maenhaut C, et al. Gene signature of the post-Chernobyl papillary thyroid cancer. Eur J Nucl Med Mol Imaging. 2016;43:1267-77 pubmed publisher
    ..Ten genes (PPME1, HDAC11, SOCS7, CIC, THRA, ERBB2, PPP1R9A, HDGF, RAD51AP1, and CDK1) from the 19 investigated with quantitative RT-PCR were confirmed as ..
  7. Nishide S, Honma S, Honma K. Two coupled circadian oscillations regulate Bmal1-ELuc and Per2-SLR2 expression in the mouse suprachiasmatic nucleus. Sci Rep. 2018;8:14765 pubmed publisher
    ..Bmal1 is the component of a Bmal1/REV-ERBa/ROR loop and Per2 a Per/Cry/BMAL1/CLOCK loop...
  8. Butler A, Burris T. Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB. Cell Metab. 2015;22:197-8 pubmed publisher
    ..A report in Science by Zhang et al. (2015) redefines our understanding of how Rev-erba acts as an internal feedback inhibitor that modulates activity of the core clock while simultaneously regulating ..
  9. Gunel E, Polat Kilic G, Bulut E, Durul B, Acar S, Alpas H, et al. Salmonella surveillance on fresh produce in retail in Turkey. Int J Food Microbiol. 2015;199:72-7 pubmed publisher
    ..of isolates, serotyping, antimicrobial susceptibility testing, multi-locus sequence typing (MLST; aroC, thrA, purE, sucA, hisD, hemD and dnaN) and pulsed-field gel electrophoresis (PFGE) were performed...
  10. Juszczak G, Stankiewicz A. Glucocorticoids, genes and brain function. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:136-168 pubmed publisher junctions (Gjb6), immune response (Tiparp, Mertk, Lyve1 and Il6r), signaling mediated by thyroid hormones (Thra and Sult1a1), calcium (Calm2), adrenaline/noradrenaline (Adcy9 and Adra1d), neuropeptide Y (Npy1r) and histamine (..
  11. Lee S, Jung S, Kim Y, Na S, Lee Y, Lee J. Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2. Mol Endocrinol. 2001;15:241-54 pubmed
    ..From these results, we concluded that ASC-2 directly binds to nuclear receptors and recruits CBP to mediate the nuclear receptor transactivation in vivo. ..
  12. Liu Y, Kogai T, Schultz J, Mody K, Brent G. Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation. J Biol Chem. 2012;287:36499-508 pubmed publisher
    ..These findings demonstrate that conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression. ..
  13. Morte B, Gil Ibáñez P, Bernal J. Regulation of Gene Expression by Thyroid Hormone in Primary Astrocytes: Factors Influencing the Genomic Response. Endocrinology. 2018;159:2083-2092 pubmed publisher
    ..thyroid hormone metabolism and action encoding type 2 deiodinase (Dio2), Mct8 transporter (Slc16a2), T3 receptors (Thra1 and Thrb), and nuclear corepressor (Ncor1) and coactivator (Ncoa1). T3 changed the expression of 668 genes (4...
  14. Treuter E, Johansson L, Thomsen J, Wärnmark A, Leers J, Pelto Huikko M, et al. Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes. J Biol Chem. 1999;274:6667-77 pubmed
  15. Long W, Lu G, Zhou W, Yang Y, Zhang B, Zhou H, et al. Targeted next-generation sequencing of thirteen causative genes in Chinese patients with congenital hypothyroidism. Endocr J. 2018;65:1019-1028 pubmed publisher
    ..9.09% (12/132) mutations related to GNAS, which was associated with thyrotropin resistance. No mutation of THRA, TSHB, IYD or SLC5A5 was detected. Among 69 mutations detected patients, 41 (59...
  16. Elliott M, Jerzak K, Cockburn J, Safikhani Z, Gwynne W, Hassell J, et al. The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism. Sci Rep. 2018;8:16562 pubmed publisher
    Previous research has suggested that thyroid hormone receptor alpha 1 (THRα1), a hormone responsive splice variant, may play a role in breast cancer progression. Whether THRα1 can be exploited for anti-cancer therapy is unknown...
  17. Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K, et al. Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell. 1989;57:31-9 pubmed
    Two erbA homologs, termed ear-1 and ear-7, are present in the human genome on chromosome 17. The two genes reside in the same genetic locus with overlapping exons and are transcribed from opposite DNA strands...
  18. Polly P, Herdick M, Moehren U, Baniahmad A, Heinzel T, Carlberg C. VDR-Alien: a novel, DNA-selective vitamin D(3) receptor-corepressor partnership. FASEB J. 2000;14:1455-63 pubmed
    ..Taken together, association of the VDR with corepressor proteins provides a further level of transcriptional regulation, which is emerging as a complex network of protein-protein interaction-mediated control. ..
  19. Busson M, Carazo A, Seyer P, Grandemange S, Casas F, Pessemesse L, et al. Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. Oncogene. 2005;24:1698-710 pubmed
    ..It not only stimulates the activity of myogenic factors, but also of nuclear receptors already known as positive myogenic regulators. ..
  20. Sarkar D, Singh S. Effect of neonatal hypothyroidism on prepubertal mouse testis in relation to thyroid hormone receptor alpha 1 (THR?1). Gen Comp Endocrinol. 2017;251:109-120 pubmed publisher
    ..the effect of neonatal hypothyroidism on prepubertal Parkes (P) strain mice testis in relation to thyroid hormone receptor alpha 1 (THR?1)...
  21. Zhang G, Haroon M, Zhang R, Dong X, Wang D, Liu Y, et al. Ruegeria profundi sp. nov. and Ruegeria marisrubri sp. nov., isolated from the brine-seawater interface at Erba Deep in the Red Sea. Int J Syst Evol Microbiol. 2017;67:4624-4631 pubmed publisher
    ..designated ZGT108T and ZGT118T, were isolated from the brine-seawater interface at Erba Deep in the Red Sea (Saudi Arabia)...
  22. Eghlidi D, Luna S, Brown D, Garyfallou V, Kohama S, Urbanski H. Gene expression profiling of the SCN in young and old rhesus macaques. J Mol Endocrinol. 2018;61:57-67 pubmed publisher
    ..polypeptide, calbindin and nuclear receptor subfamily 1, group D, member 1 (NR1D1) (also known as reverse strand of ERBA (REV-ERBα), both at the mRNA and protein level...
  23. Bao L, Rodiger J, Park S, Fu L, Shi B, Cheng S, et al. TRα mutations lead to epithelial defects in the adult intestine in a mouse model of resistance to thyroid hormone. Thyroid. 2018;: pubmed publisher
    ..identification of the genetic mutations only in the THRB gene in these patients suggest that mutations in the THRA gene may have different pathological manifestations in humans...
  24. Lee J, Choi H, Gyuris J, Brent R, Moore D. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol Endocrinol. 1995;9:243-54 pubmed
  25. Ng L, Rusch A, Amma L, Nordstrom K, Erway L, Vennstrom B, et al. Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene. Hum Mol Genet. 2001;10:2701-8 pubmed
    ..Here, we have determined that a targeted mutation (Thra(tm2)) in the related Thra gene, encoding thyroid hormone receptor alpha suppresses these phenotypes in mice...
  26. Grespin M, Bonamy G, Roggero V, Cameron N, Adam L, Atchison A, et al. Thyroid hormone receptor alpha1 follows a cooperative CRM1/calreticulin-mediated nuclear export pathway. J Biol Chem. 2008;283:25576-88 pubmed publisher
  27. Laé M, Gardrat S, Rondeau S, Richardot C, Caly M, Chemlali W, et al. MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways. Oncotarget. 2016;7:84428-84438 pubmed publisher
    ..with altered expressions of the genes involved in the WNT (PAX3, WNT3A, AXIN2), TGFB (TAGLN, TGFBR2, CTGF) and THRA (RXRA, THRA) signaling pathways...
  28. Ma H, Yang F, Butler M, Belcher J, Redmond T, Placzek A, et al. Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration. FASEB J. 2017;31:3425-3438 pubmed publisher
    ..In this work, we investigated the effectiveness of inhibition of the TH receptor (TR). Two genes, THRA and THRB, encode TRs; THRB2 has been associated with cone viability...
  29. Williams G, Bassett J. Thyroid diseases and bone health. J Endocrinol Invest. 2018;41:99-109 pubmed publisher
    ..characteristic of hypothyroidism occurs in children with resistance to thyroid hormone due to mutations affecting THRA encoding thyroid hormone receptor ? (TR?)...
  30. Baida A, Farrington S, Galofré P, Marcos R, Velázquez A. Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. Cancer Epidemiol Biomarkers Prev. 2005;14:638-42 pubmed
    ..Here, we have carried out a case-control study to investigate whether there is an association between THRA1 CA repeat or BAT-40 A repeat polymorphisms and thyroid cancer risk...
  31. Blanchet E, Bertrand C, Annicotte J, Schlernitzauer A, Pessemesse L, Levin J, et al. Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis. FASEB J. 2012;26:40-50 pubmed publisher
    ..We have previously identified a mitochondrial triiodothyronine receptor (p43) that acts as a mitochondrial transcription factor of the organelle genome, which leads, in vitro ..
  32. Alyusuf R, Matouq J, Taha S, Wazir J. The pattern of expression and role of triiodothyronine (T3) receptors and type I 5'-deiodinase in breast carcinomas, benign breast diseases, lactational change, and normal breast epithelium. Appl Immunohistochem Mol Morphol. 2014;22:518-23 pubmed publisher
    ..The presence of THRs in mammary epithelium seems to be protective against the development of breast cancer. This could serve as a potential prognostic and therapeutic target for breast cancer. ..
  33. Chen C, Ma Q, Chen X, Zhong M, Deng P, Zhu G, et al. Thyroid Hormone-Otx2 Signaling Is Required for Embryonic Ventral Midbrain Neural Stem Cells Differentiated into Dopamine Neurons. Stem Cells Dev. 2015;24:1751-65 pubmed publisher
    ..Finally, we revealed both in vivo and in vitro that the thyroid hormone receptor alpha 1 is expressed in embryonic VM NSCs...
  34. Khan S, Wall D, Curran C, Newell J, Kerin M, Dwyer R. MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid. BMC Cancer. 2015;15:345 pubmed publisher
    ..Gene expression of Retinoic Acid Receptor beta (RARβ) and Thyroid Hormone receptor alpha (THRα) was also quantified in the same patient samples (n = 168)...
  35. Ma Z, Yu Y, Tang S, Liu H, Su G, Xie Y, et al. Differential modulation of expression of nuclear receptor mediated genes by tris(2-butoxyethyl) phosphate (TBOEP) on early life stages of zebrafish (Danio rerio). Aquat Toxicol. 2015;169:196-203 pubmed publisher
    ..under control of several nuclear hormone receptors (estrogen receptors (ERs), androgen receptor (AR), thyroid hormone receptor alpha (TRα), mineralocorticoid receptor (MR), glucocorticoid receptor (GR), aryl hydrocarbon (AhR), ..
  36. Muscat G, Mynett Johnson L, Dowhan D, Downes M, Griggs R. Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors. Nucleic Acids Res. 1994;22:583-91 pubmed
    ..In vitro binding studies showed that the thyroid hormone receptor alpha (TR alpha) formed a heterodimeric complex, with either the retinoid X receptor alpha or gamma 1 ..
  37. Lin H, Zhao L, Cheng S. Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. J Biol Chem. 2002;277:28733-41 pubmed
    ..Thus, cyclin D1 is a novel ligand-independent co-repressor that opens a new paradigm to understand the molecular basis of the silencing action of TR. ..
  38. Lado Abeal J, Romero A, Castro Piedras I, Rodriguez Perez A, Alvarez Escudero J. Thyroid hormone receptors are down-regulated in skeletal muscle of patients with non-thyroidal illness syndrome secondary to non-septic shock. Eur J Endocrinol. 2010;163:765-73 pubmed publisher
    ..We also investigated whether the patient's serum can induce in vitro the effects observed in vivo...
  39. Zhu X, Kim D, Goodson M, Privalsky M, Cheng S. NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis. J Mol Endocrinol. 2011;46:233-44 pubmed publisher
  40. Rajatapiti P, Keijzer R, Blommaart P, Lamers W, de Krijger R, Visser T, et al. Spatial and temporal expression of glucocorticoid, retinoid, and thyroid hormone receptors is not altered in lungs of congenital diaphragmatic hernia. Pediatr Res. 2006;60:693-8 pubmed
    ..Our results suggest that, as far as receptors are concerned, hypoplastic lungs of fetuses and newborns with CDH are potentially as responsive to glucocorticoids, thyroid hormone, and retinoic acid as the lungs of normal children. ..
  41. Jolley C, Ukai Tadenuma M, Perrin D, Ueda H. A mammalian circadian clock model incorporating daytime expression elements. Biophys J. 2014;107:1462-73 pubmed publisher
    ..Our model reproduces predictions concerning the dual regulation of Cry1 by the D-box and Rev-ErbA/ROR response element (RRE) promoter elements and allows for ensemble-based predictions of phase response curves (..
  42. Takada H, Miwa Y, Sato I. Expression of myostatin in early postnatal mouse masseter and rectus femoris muscles. Histol Histopathol. 2015;30:1353-65 pubmed publisher
    ..In this study, we aimed to identify the relationships between Mstn, thyroid hormone receptor alpha (TRα), and myosin heavy chain (MyHC) isoform expression during early postnatal development...
  43. Kallalli B, Rawson K, Muzammil -, Singh A, Awati M, Shivhare P. Lactate dehydrogenase as a biomarker in oral cancer and oral submucous fibrosis. J Oral Pathol Med. 2016;45:687-690 pubmed publisher
    ..Following which, the collected saliva was centrifuged and then analyzed by ERBA-CHEM 5 semi auto-analyzer...
  44. Carpagnano G, Lacedonia D, Soccio P, Caccavo I, Patricelli G, Foschino Barbaro M. How strong is the association between IPF and lung cancer? An answer from airway's DNA. Med Oncol. 2016;33:119 pubmed publisher
    ..The EBC was collected using a condenser. Four microsatellite markers (THRA1, D17S579, D17S250 and D8S137) were used for the analysis of MAs...
  45. Samarut J, Plateroti M. Thyroid Hormone Receptors: Several Players for One Hormone and Multiple Functions. Methods Mol Biol. 2018;1801:1-8 pubmed publisher
    Thyroid hormone receptors (TRs) were cloned based on their homology with the retroviral oncogene v-ERBA. In Vertebrates two genes, THRA and THRB, encode respectively many isotypes and isoforms of receptors TRα and TRβ, resulting from ..
  46. Mavroudis P, Dubois D, Almon R, Jusko W. Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat. PLoS ONE. 2018;13:e0197534 pubmed publisher
    ..genes and further predicted that their phases are mainly regulated by Per2 and Cry1 transcriptional delays and Rev-Erba and Cry1 degradation rates...
  47. Ji Z, Liu T, Zhang J, Yan H, Wang E, Cui Q, et al. Genetic divergence among Bradyrhizobium strains nodulating wild and cultivated Kummerowia spp. in China. Syst Appl Microbiol. 2019;42:223-231 pubmed publisher groups, were identified based on a concatenated sequence analysis of taxonomic markers (SMc00019, truA and thrA) for 94 representative strains...
  48. Yanagisawa R, Koike E, Win Shwe T, Takano H. Decabromodiphenyl ether exacerbates hyperglycemia in diet-induced obese mice. Toxicology. 2018;412:12-18 pubmed publisher
    ..DecaBDE exposure significantly reduced mRNA levels of glucose transporter 4 and thyroid hormone receptor alpha in skeletal muscle and mechanistic target of rapamycin complex 2 in brown adipose tissue compared with ..
  49. Georgescu S, Li J, Lu Q, Karas R, Brown M, Mendelsohn M. Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha. Mol Endocrinol. 2005;19:2491-501 pubmed
    ..These data identify MRF1 as a repressor of ERalpha-mediated transcriptional activation and support a role for MRF1 in regulating ER-dependent gene expression in cardiovascular and other cells. ..
  50. Aghajanova L, Stavreus Evers A, Lindeberg M, Landgren B, Sparre L, Hovatta O. Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology. Fertil Steril. 2011;95:230-7, 237.e1-2 pubmed publisher
    ..Thyroid hormones are directly involved in endometrial physiology. ..
  51. Bassett J, Boyde A, Zikmund T, Evans H, Croucher P, Zhu X, et al. Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice. Endocrinology. 2014;155:3699-712 pubmed publisher
    ..b>Thra1(PV/+) mice express a similar potent dominant-negative mutant TRα1 to affected individuals, and thus represent an ..
  52. Chatonnet F, Livera G, Fumel B, FouchÉCourt S, Flamant F. Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells. Mol Reprod Dev. 2014;81:1159-66 pubmed publisher
    ..This differential analysis provides genetic clues to the initial testicular defects resulting from disrupted thyroid hormone signaling, and suggests that Sertoli cells influence germ cells soon after their birth. ..
  53. Wang Y, Fisahn A, Sinha I, Nguyen D, Sterzenbach U, Lallemend F, et al. Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone. Sci Rep. 2016;6:18617 pubmed publisher
    Hypothyroidism due to THRA1 (gene coding for thyroid hormone receptor α1) mutation-mediated Resistance to Thyroid Hormone (RTH) has been recently reported in human and is associated with memory deficits similar to those found in a ..
  54. Sarkar D, Singh V, Singh S. Maternal BDE-209 exposure during lactation perturbs steroidogenesis, germ cell kinetics and THRα1 expression in testes of prepubertal mice offspring. Food Chem Toxicol. 2018;122:104-119 pubmed publisher
    ..BDE-209 exposure during lactation on testicular steroidogenesis and spermatogenesis in relation to thyroid hormone receptor alpha 1 (THRα1) and possible mechanism(s) of its action in prepubertal Parkes mice offspring...
  55. Bondzi C, Brunner A, Munyikwa M, Connor C, Simmons A, Stephens S, et al. Recruitment of the oncoprotein v-ErbA to aggresomes. Mol Cell Endocrinol. 2011;332:196-212 pubmed publisher
    ..Previously we showed that Gag-v-ErbA (v-ErbA), a retroviral variant of the thyroid hormone receptor (TR?1), accumulates in and sequesters TR?1 into ..
  56. Kurylowicz A, Jonas M, Lisik W, Jonas M, Wicik Z, Wierzbicki Z, et al. Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues. J Transl Med. 2015;13:31 pubmed publisher
    ..The expression of ADRB2, ADRB3, THRA, THRB, DIO2, UCP2 was significantly lower in the adipose tissues of obese patients than in tissues of normal-weight ..
  57. Zhang G, Fauzi Haroon M, Zhang R, Hikmawan T, Stingl U. Draft Genome Sequence of Pseudoalteromonas sp. Strain XI10 Isolated from the Brine-Seawater Interface of Erba Deep in the Red Sea. Genome Announc. 2016;4: pubmed publisher
    Pseudoalteromonas sp. strain XI10 was isolated from the brine-seawater interface of Erba Deep in the Red Sea, Saudi Arabia...
  58. Gauthier K. Protocols for Studying How Thyroid Hormone Receptors Trigger Adaptive Thermogenesis in Mice. Methods Mol Biol. 2018;1801:105-110 pubmed publisher
    ..Knock-in mutation of TR in specific metabolic tissues are currently generated using conditional mutant alleles of THRA (Quignodon et al., Mol Endocrinol 21:2350-2360, 2007) and THRB (Billon et al., Endocrinology 155:2735-2745, 2014)...
  59. Caira F, Antonson P, Pelto Huikko M, Treuter E, Gustafsson J. Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J Biol Chem. 2000;275:5308-17 pubmed
    ..Together, our data suggest that RAP250 may play an important role in mammalian gene expression mediated by nuclear receptor. ..
  60. Li J, Lin Q, Yoon H, Huang Z, Strahl B, Allis C, et al. Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Mol Cell Biol. 2002;22:5688-97 pubmed
  61. Méndez Pertuz M, Sánchez Pacheco A, Aranda A. The thyroid hormone receptor antagonizes CREB-mediated transcription. EMBO J. 2003;22:3102-12 pubmed
    ..These results indicate the existence of a transcriptional cross-talk between CREB and TR signalling pathways, which can have important functional consequences. ..
  62. Chen P, Syu G, Chung K, Ho Y, Chung F, Chen P, et al. Antibody profiling of bipolar disorder using Escherichia coli proteome microarrays. Mol Cell Proteomics. 2015;14:510-8 pubmed publisher
    ..The trained diagnosis committee in BD-A versus HC combined top six proteins, including rpoA, thrA, flhB, yfcI, ycdU, and ydjL...
  63. Persaud S, Huang W, Park S, Wei L. Gene repressive activity of RIP140 through direct interaction with CDK8. Mol Endocrinol. 2011;25:1689-98 pubmed publisher
    ..This underlies the T(3)-triggered repression of CrabpI gene. This study illustrates a new gene-repressive mechanism of RIP140 that can affect the transcription machinery by directly interacting with CDK8. ..
  64. Hahm J, Schroeder A, Privalsky M. The two major isoforms of thyroid hormone receptor, TR?1 and TR?1, preferentially partner with distinct panels of auxiliary proteins. Mol Cell Endocrinol. 2014;383:80-95 pubmed publisher
  65. Mundhada H, Seoane J, Schneider K, Koza A, Christensen H, Klein T, et al. Increased production of L-serine in Escherichia coli through Adaptive Laboratory Evolution. Metab Eng. 2017;39:141-150 pubmed publisher
    ..Genome sequencing of isolated clones revealed multiplication of genetic regions, as well as mutations in thrA, thereby showing a potential mechanism of serine inhibition...
  66. Préfontaine G, Walther R, Giffin W, Lemieux M, Pope L, Hache R. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. J Biol Chem. 1999;274:26713-9 pubmed
  67. Lee S, Anzick S, Choi J, Bubendorf L, Guan X, Jung Y, et al. A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. J Biol Chem. 1999;274:34283-93 pubmed
    ..From these results, we concluded that ASC-2 is a bona fide transcription coactivator molecule of nuclear receptors, and its altered expression may contribute to the development of cancers. ..
  68. Mengus G, Gangloff Y, Carre L, Lavigne A, Davidson I. The human transcription factor IID subunit human TATA-binding protein-associated factor 28 interacts in a ligand-reversible manner with the vitamin D(3) and thyroid hormone receptors. J Biol Chem. 2000;275:10064-71 pubmed
    ..We also describe a mutation in the H3-H5 region of the VDR LBD, which abolishes transactivation, and we show that interaction of hTAF(II)28 with this mutant is no longer ligand-reversible. ..
  69. Lamy P, Fina F, Bascoul Mollevi C, Laberenne A, Martin P, Ouafik L, et al. Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers. Breast Cancer Res. 2011;13:R15 pubmed publisher
    ..polymerase chain reaction method and DNA extracted from frozen tumor specimens, 11 genes (MED1, STARD3, HER2, GRB7, THRA, RARA, TOP2A, IGFBP4, CCR7, KRT20, KRT19 and GAS), which are localized within Chr17q12-q21 and have a putative role ..
  70. Cunha Lima S, Rodrigues E. The oligomeric state of thyroid receptor regulates hormone binding kinetics. J Endocrinol. 2011;210:125-34 pubmed publisher
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    ..of Sertoli cells, which continue to express the immaturity markers anti-Mullerian hormone and thyroid hormone receptor alpha in adults and fail to express the maturation marker p27(Kip1)...
  72. Moran C, Agostini M, Visser W, Schoenmakers E, Schoenmakers N, Offiah A, et al. Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor (TR)?1 and TR?2: clinical, biochemical, and genetic analyses of three related patients. Lancet Diabetes Endocrinol. 2014;2:619-26 pubmed publisher
    The thyroid hormone receptor ? gene (THRA) transcript is alternatively spliced to generate either thyroid hormone receptor (TR)?1 or a non-hormone-binding variant protein, TR?2, the function of which is unknown...
  73. Bertrand Gaday C, Pessemesse L, Cabello G, Wrutniak Cabello C, Casas F. Temperature homeostasis in mice lacking the p43 mitochondrial T3 receptor. FEBS Lett. 2016;590:982-91 pubmed publisher
    Thyroid hormones and Thra gene play a key role in energy expenditure regulation, temperature homeostasis, and mitochondrial function...
  74. Bloise F, Cordeiro A, Ortiga Carvalho T. Role of thyroid hormone in skeletal muscle physiology. J Endocrinol. 2018;236:R57-R68 pubmed publisher
    ..on the presence of the TH transporters MCT8 and MCT10 in the plasma membrane, the expression of TH receptors (THRA or THRB) and hormone availability, which is determined either by the activation of thyroxine (T4) into ..
  75. Aguayo Mazzucato C, Lee T, Matzko M, DiIenno A, Rezanejad H, Ramadoss P, et al. T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells. Diabetes. 2018;67:1322-1331 pubmed publisher
    ..Using specific agonists CO23 and GC1, we showed that p16Ink4a expression was controlled by THRA and Mafa by THRB...
  76. Sakurai A, Nakai A, DeGroot L. Expression of three forms of thyroid hormone receptor in human tissues. Mol Endocrinol. 1989;3:392-9 pubmed
    ..The relative amounts of the three hTR mRNAs were roughly parallel in each tissue. It is of interest that none of these hTRs was abundant in liver, which is the major thyroid hormone-responsive organ. Another hTR may be present in liver. ..
  77. Desai Yajnik V, Samuels H. Regulation of the human immunodeficiency virus type 1 long terminal repeat: interactions of thyroid hormone receptor with retinoid-X receptor, nuclear factor kappa B, Sp1, and Tat. Trans Assoc Am Physicians. 1993;106:13-32 pubmed
  78. Zhang G, Haroon M, Zhang R, Dong X, Liu D, Xiong Q, et al. Ponticoccus marisrubri sp. nov., a moderately halophilic marine bacterium of the family Rhodobacteraceae. Int J Syst Evol Microbiol. 2017;67:4358-4364 pubmed publisher
    ..coccus-shaped, non-motile, aerobic bacterium, was isolated from the brine-seawater interface of the Erba Deep in the Red Sea, Saudi Arabia...
  79. Buchholz D, Shi Y. Dual function model revised by thyroid hormone receptor alpha knockout frogs. Gen Comp Endocrinol. 2018;265:214-218 pubmed publisher
    ..Full evaluation of the dual function model for all organs awaits the production of TR? and TR? double knockout frogs. ..
  80. Vancamp P, Houbrechts A, Darras V. Insights from zebrafish deficiency models to understand the impact of local thyroid hormone regulator action on early development. Gen Comp Endocrinol. 2018;: pubmed publisher to overall hypo-/hyperthyroidism, inactivating mutations in the genes encoding TH regulators such as MCT8 and THRA/B have irreversible adverse effects on human development...
  81. Nakai A, Sakurai A, Bell G, DeGroot L. Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues. Mol Endocrinol. 1988;2:1087-92 pubmed
    ..At least three types of thyroid hormone receptors (hTR alpha 1, alpha 2, beta), which possess similar affinities for hormone ligands, can be expressed in the same tissue. ..
  82. Berghagen H, Ragnhildstveit E, Krogsrud K, Thuestad G, Apriletti J, Saatcioglu F. Corepressor SMRT functions as a coactivator for thyroid hormone receptor T3Ralpha from a negative hormone response element. J Biol Chem. 2002;277:49517-22 pubmed
    ..This, in turn, greatly expands the repertoire of mechanisms used in modulating transcription without the need for expression of new regulatory molecules. ..
  83. Rebai M, Kallel I, Rebai A. Genetic features of thyroid hormone receptors. J Genet. 2012;91:367-74 pubmed
    ..Therefore, further investigations are needed in order to use these receptors as therapeutic targets or as biological markers to decide on appropriate forms of treatment. ..
  84. Pérez Yépez J, Armas Capote N, Velázquez E, Pérez Galdona R, Rivas R, León Barrios M. Evaluation of seven housekeeping genes for multilocus sequence analysis of the genus Mesorhizobium: Resolving the taxonomic affiliation of the Cicer canariense rhizobia. Syst Appl Microbiol. 2014;37:553-9 pubmed, multilocus sequence analysis (MLSA) of seven protein-coding genes, recA, glnII, dnaK, rpoB, gyrB, truA and thrA, was used to resolve the phylogenetic relationships and taxonomic affiliation of 27 representative strains from all ..
  85. Wan W, Farboud B, Privalsky M. Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function. Mol Endocrinol. 2005;19:1529-42 pubmed
    ..In contrast, the TRbeta mutations associated with pituitary RTH disproportionately disrupt the pituitary's ability to sense and suppress elevated T3 levels in advance of the periphery, producing symptoms of thyrotoxicity. ..
  86. Tan X, Fan X, Kim H, Butler R, Webb P, Warner M, et al. Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering. Proc Natl Acad Sci U S A. 2010;107:12305-10 pubmed publisher
    In the past year, two members of the nuclear receptor family, liver X receptor beta (LXRbeta) and thyroid hormone receptor alpha (TRalpha), have been found to be essential for correct migration of neurons in the developing cortex in mouse ..
  87. Joseph B, Ji M, Liu D, Hou P, Xing M. Lack of mutations in the thyroid hormone receptor (TR) alpha and beta genes but frequent hypermethylation of the TRbeta gene in differentiated thyroid tumors. J Clin Endocrinol Metab. 2007;92:4766-70 pubmed
  88. Vattai A, Ziegelmüller B, Kost B, Kuhn C, Hofmann S, Bayer B, et al. The expression of thyroid hormone receptors (THR) is regulated by the progesterone receptor system in first trimester placental tissue and in BeWo cells in vitro. Eur J Obstet Gynecol Reprod Biol. 2015;195:31-9 pubmed publisher
    ..On mRNA level, we also found a significantly reduced expression of THRA but no significant downregulation for THRB in placental tissue...
  89. Zhao H, Fang Y, Wang X, Zhao L, Wang J, Li Y. Increasing L-threonine production in Escherichia coli by engineering the glyoxylate shunt and the L-threonine biosynthesis pathway. Appl Microbiol Biotechnol. 2018;102:5505-5518 pubmed publisher
    ..Three key genes in the biosynthetic pathway of L-threonine, thrA * (a mutated thrA), thrB, and thrC were overexpressed in TWF006, resulting the strain TWF006/pFW01-thrA <..
  90. Yen P, Sunday M, Darling D, Chin W. Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries. Endocrinology. 1992;130:1539-46 pubmed
    ..we have raised isoform-specific polyclonal antibodies in female New Zealand White rabbits against the rat TRs and c-erbA alpha-2, a carboxy-terminal variant of TR alpha-1 that does not bind thyroid hormone...
  91. Fondell J, Brunel F, Hisatake K, Roeder R. Unliganded thyroid hormone receptor alpha can target TATA-binding protein for transcriptional repression. Mol Cell Biol. 1996;16:281-7 pubmed
    Unliganded human thyroid hormone receptor alpha (hTR alpha) can repress transcription by inhibiting the formation of a functional preinitiation complex (PIC) on promoters bearing thyroid hormone receptor (TR)-binding elements...