thioredoxin related transmembrane protein

Summary

Gene Symbol: thioredoxin related transmembrane protein
Description: thioredoxin related transmembrane protein 1
Alias: PDIA11, TMX, TXNDC, TXNDC1, thioredoxin-related transmembrane protein 1, protein disulfide isomerase family A, member 11, thioredoxin domain containing 1, thioredoxin domain-containing protein 1, transmembrane Trx-related protein
Species: human

Top Publications

  1. Matsuo Y, Akiyama N, Nakamura H, Yodoi J, Noda M, Kizaka Kondoh S. Identification of a novel thioredoxin-related transmembrane protein. J Biol Chem. 2001;276:10032-8 pubmed
    ..Here we report the molecular cloning and characterization of one of these genes, designated TMX, that encodes a novel protein of 280 amino acid residues...
  2. Matsuo Y, Masutani H, Son A, Kizaka Kondoh S, Yodoi J. Physical and functional interaction of transmembrane thioredoxin-related protein with major histocompatibility complex class I heavy chain: redox-based protein quality control and its potential relevance to immune responses. Mol Biol Cell. 2009;20:4552-62 pubmed publisher
    ..Here, we characterize a transmembrane thioredoxin-related protein (TMX), a membrane-bound oxidoreductase in the ER...
  3. Müller G, Lüchmann K, Razzera G, Toledo Silva G, Bebianno M, Marques M, et al. Proteomic response of gill microsomes of Crassostrea brasiliana exposed to diesel fuel water-accommodated fraction. Aquat Toxicol. 2018;201:109-118 pubmed publisher
    ..The present work can be a basis for future ecotoxicological studies in oysters aiming to elucidate the molecular mechanisms behind diesel-WAF toxicity and for environmental monitoring programs. ..
  4. Wang F, Wang L, Jiang H, Chang X, Pan J. Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis. J Rheumatol. 2015;42:161-9 pubmed publisher
    ..PCSK6 is upregulated in the synovial tissues of patients with RA and has a genetic effect on the risk of RA. Inhibition of PCSK6 may play a protective role in the development of RA. ..
  5. Hedrick E, Lee S, Doddapaneni R, Singh M, Safe S. Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy. Endocr Relat Cancer. 2015;22:831-40 pubmed publisher
    ..They demonstrate the potential clinical applications of NR4A1 antagonists in patients with tumors that overexpress this receptor. ..
  6. Hyer M, Khantsis S, Venezia A, Madison F, Hallgarth L, Adekola E, et al. Estrogen-dependent modifications to hippocampal plasticity in paternal California mice (Peromyscus californicus). Horm Behav. 2017;96:147-155 pubmed publisher
    ..behavior by treating virgin and paternal males with saline or the selective estrogen receptor modulator, tamoxifen (TMX), during the time of axon extension (i.e., one week after bromodeoxyuridine injection)...
  7. Hedrick E, Lee S, Kim G, Abdelrahim M, Jin U, Safe S, et al. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS ONE. 2015;10:e0128308 pubmed publisher
    ..These results indicate that NR4A1 antagonists target multiple growth promoting and pro-survival pathways in RCC cells and in tumors (xenograft) and represent a novel chemotherapy for treating RCC. ..
  8. Price M, Sisson J. Redox regulation of motile cilia in airway disease. Redox Biol. 2019;:101146 pubmed publisher
    ..Finally, we review disease models such as smoking, asthma, alcohol drinking, and infections as well as the direct application of oxidants that implicate redox balance as a modulator of cilia motility. ..
  9. Mo R, Peng J, Xiao J, Ma J, Li W, Wang J, et al. High TXNDC5 expression predicts poor prognosis in renal cell carcinoma. Tumour Biol. 2016;37:9797-806 pubmed publisher
    ..In summary, our findings indicate that TXNDC5 performs an essential function in ccRCC pathogenesis and can serve as a novel prognostic marker of ccRCC. ..

More Information

Publications121 found, 100 shown here

  1. Wang H, Sit W, Tipoe G, Wan J. Differential protective effects of extra virgin olive oil and corn oil in liver injury: a proteomic study. Food Chem Toxicol. 2014;74:131-8 pubmed publisher
    ..Our findings confirmed the benefits of EVOO against chronic liver injury, which may be attributable to the antioxidant effects, hepatocellular function regulation and hepatic metabolism modification effects of EVOO. ..
  2. Conejo I, Pajares B, Alba E, Cuesta Vargas A. Effect of neuromuscular taping on musculoskeletal disorders secondary to the use of aromatase inhibitors in breast cancer survivors: a pragmatic randomised clinical trial. BMC Complement Altern Med. 2018;18:180 pubmed publisher
    ..This study included 40 BC survivors receiving endocrine therapy (either AIs or TMX) from Hospital Universitario Virgen de la Victoria (Málaga, Spain) suffered from AIA...
  3. Chiang Y, Wang R, Huang C, Chen S, Ho W, Lane H, et al. Reduced dosing and liability in methadone maintenance treatment by targeting oestrogen signal for morphine addiction. J Cell Mol Med. 2017;21:3552-3564 pubmed publisher
    ..At last, preclinical study via targeting estrogen signal that tamoxifen (TMX; selective estrogen receptor modulator, SERM) could facilitate the tolerance phase rewarding response of methadone...
  4. Lacey A, Hedrick E, Li X, Patel K, Doddapaneni R, Singh M, et al. Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS). Oncotarget. 2016;7:31257-69 pubmed publisher
  5. Schubert K, Stacey D, Arentz G, Clark S, Air T, Hoffmann P, et al. Targeted proteomic analysis of cognitive dysfunction in remitted major depressive disorder: Opportunities of multi-omics approaches towards predictive, preventive, and personalized psychiatry. J Proteomics. 2018;188:63-70 pubmed publisher
  6. Harz C, Ludwig N, Lang S, Werner T, Galata V, Backes C, et al. Secretion and immunogenicity of the meningioma-associated antigen TXNDC16. J Immunol. 2014;193:3146-54 pubmed publisher
    ..2% using a set of only five immunogenic TXNDC16 epitopes. ..
  7. Ivanova A, Shandarin I, Ermakova G, Minin A, Tereshina M, Zaraisky A. The secreted factor Ag1 missing in higher vertebrates regulates fins regeneration in Danio rerio. Sci Rep. 2015;5:8123 pubmed publisher
    ..These data are in a good agreement with the assumption that the loss of Ag1 in higher vertebrates ancestors could lead to the reduction of the regenerative capacity in their modern descendants. ..
  8. Horna Terrón E, Pradilla Dieste A, Sánchez de Diego C, Osada J. TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology. Int J Mol Sci. 2014;15:23501-18 pubmed publisher
    ..Its implication in all these important diseases has made TXNDC5 a susceptible biomarker or even a potential pharmacological target. ..
  9. Xu B, Li J, Wu C, Liu C, Yan X, Chang X. CXCL10 and TRAIL Are Upregulated by TXNDC5 in Rheumatoid Arthritis Fibroblast-like Synoviocytes. J Rheumatol. 2018;45:335-340 pubmed publisher
    ..Downregulation of TXNDC5 could contribute to RASF antiangiogenic and proapoptotic features through the suppression of CXCL10 and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). ..
  10. Chen M, Zhang J, Pang S, Wang C, Wang L, Sun Y, et al. Evaluating estrogenic and anti-estrogenic effect of endocrine disrupting chemicals (EDCs) by zebrafish (Danio rerio) embryo-based vitellogenin 1 (vtg1) mRNA expression. Comp Biochem Physiol C Toxicol Pharmacol. 2018;204:45-50 pubmed publisher
    ..E3), synthetic hormones including diethylstilbestrol (DES), 4-octyl phenol (OP), bisphenol A (BPA), tamoxifen (TMX) and 3-(2,3-dibromopropyl) isocyanurate (TBC)...
  11. Zhao Z, Wu Y, Zhou J, Chen F, Yang A, Essex D. The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses. Blood. 2018;: pubmed publisher
    ..Thus, TMX1 is the first identified extracellular inhibitor of platelet function and the first disulfide isomerase that negatively regulates platelet function. ..
  12. Graham C, Kaza N, Klocke B, Gillespie G, Shevde L, Carroll S, et al. Tamoxifen Induces Cytotoxic Autophagy in Glioblastoma. J Neuropathol Exp Neurol. 2016;75:946-954 pubmed
    ..4-Hydroxy tamoxifen (OHT) is an active metabolite of the tamoxifen (TMX) prodrug and a well-established estrogen receptor (ER) and estrogen-related receptor antagonist...
  13. Kim B, Lee M, Kang H, Rhee J, Lee J. Genomic organization and transcriptional modulation in response to endocrine disrupting chemicals of three vitellogenin genes in the self-fertilizing fish Kryptolebias marmoratus. J Environ Sci (China). 2016;42:187-195 pubmed publisher
    ..Km-Vtg transcripts were significantly increased in response to 17?-estradiol (E2), tamoxifen (TMX), 4-n-nonylphenol (NP), bisphenol A (BPA), and octylphenol (OP) over 24hr exposure...
  14. Chen X, Wang J, Yue W, Liu J, Wang C. Hepatopancreas transcriptome analysis of Chinese mitten crab (Eriocheir sinensis) with white hepatopancreas syndrome. Fish Shellfish Immunol. 2017;70:302-307 pubmed publisher
    ..sinensis with white hepatopancreas syndrome. Our study provides novel insights into genetic causes of formation and novel gene markers for detection of white hepatopancreas syndrome in aquaculture of E. sinensis. ..
  15. Jie L, Li D, Yang C, Haiying Z. Tamoxifen versus clomiphene citrate for ovulation induction in infertile women. Eur J Obstet Gynecol Reprod Biol. 2018;228:57-64 pubmed publisher
    ..Our study showed that there might be some distinctions in the efficacy of TMX and CC for ovulation and pregnancy rates. However, the exact efficacy was needed to be confirmed further.
  16. Chen Y, Tsou B, Hu S, Ma H, Liu X, Yen Y, et al. Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells. Oncotarget. 2016;7:1984-99 pubmed publisher
    ..To test this hypothesis, we treated breast cancer MDA-MB-231 cells with tamoxifen (TMX), which induces autophagy through an estrogen receptor-independent pathway...
  17. Rivero Gutiérrez B, Haller A, Holland J, Yates E, Khrisna R, Habegger K, et al. Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Mol Metab. 2018;17:28-38 pubmed publisher
    ..streptozotocin (STZ) in mice with congenital or temporally-controlled Gcgr loss-of-function using tamoxifen (TMX)...
  18. Wang L, Song G, Chang X, Tan W, Pan J, Zhu X, et al. The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway. Oncogene. 2015;34:4735-45 pubmed publisher
    ..Overall, we defined an important role of TXNDC5 in CRPC and further investigations are needed to screen TXNDC5 antagonists as a novel therapeutic approaches to treat PCa patients with CRPC. ..
  19. Crespin L, Legros C, List O, Tricoire Leignel H, Mattei C. Injection of insect membrane in Xenopus oocyte: An original method for the pharmacological characterization of neonicotinoid insecticides. J Pharmacol Toxicol Methods. 2016;77:10-6 pubmed publisher
    ..We compared the effect of nicotine (NIC) with clothianidin (CLO) and we assessed the effect of thiamethoxam (TMX)...
  20. Cao Z, van Lith M, Mitchell L, Pringle M, Inaba K, Bulleid N. The membrane topology of vitamin K epoxide reductase is conserved between human isoforms and the bacterial enzyme. Biochem J. 2016;473:851-8 pubmed publisher
    ..of glycosylation sites along with mixed disulfide formation with thioredoxin-like transmembrane protein (TMX) to demonstrate ER localization of the major loop...
  21. Ma F, Hou L, Yang L. Txndc9 Is Required for Meiotic Maturation of Mouse Oocytes. Biomed Res Int. 2017;2017:6265890 pubmed publisher
    ..In summary, our results demonstrated that Txndc9 is crucial for mouse oocyte maturation by regulating spindle assembly, polar body extrusion, and redox status. ..
  22. Soni S, Raaijmakers A, Raaijmakers L, Damen J, van Stuijvenberg L, Vos M, et al. A Proteomics Approach to Identify New Putative Cardiac Intercalated Disk Proteins. PLoS ONE. 2016;11:e0152231 pubmed publisher
    ..The presented proteomics dataset of putative new ID proteins is a valuable resource for future research into this important molecular intersection of the heart. ..
  23. Saal W, Wyttenbach N, Alsenz J, Kuentz M. Interactions of dimethylaminoethyl methacrylate copolymer with non-acidic drugs demonstrated high solubilization in vitro and pronounced sustained release in vivo. Eur J Pharm Biopharm. 2018;125:68-75 pubmed publisher
    ..The current work studied EPO-mediated solubilization effects first in vitro using felodipine (FLP) and tamoxifen (TMX) as model compounds...
  24. Huang P, Chang W, Huang S. Müllerian adenosarcoma: a review of cases and literature. Eur J Gynaecol Oncol. 2014;35:617-20 pubmed
    ..There was only one post-menopausal case. One case was of breast cancer with tamoxifen (TMX) therapy...
  25. Criado Gonzalez M, Fernández Gutiérrez M, San Roman J, Mijangos C, Hernandez R. Local and controlled release of tamoxifen from multi (layer-by-layer) alginate/chitosan complex systems. Carbohydr Polym. 2019;206:428-434 pubmed publisher
    ..A specific drug against breast cancer, tamoxifen (TMX), was incorporated in different intermediate positions of the multilayer Alg/Chi films...
  26. Araki K, Ushioda R, Kusano H, Tanaka R, Hatta T, Fukui K, et al. A crosslinker-based identification of redox relay targets. Anal Biochem. 2017;520:22-26 pubmed publisher
    ..Applying multiple methods, including classical substrate-trapping techniques, will increase understanding of redox regulatory mechanisms in cells. ..
  27. Hayat S, Walter P, Park Y, Helms V. Prediction of the exposure status of transmembrane beta barrel residues from protein sequence. J Bioinform Comput Biol. 2011;9:43-65 pubmed
    ..bioinformatik.uni-saarland.de/tmx-site/. Exposure status prediction of TMB residues may be useful in 3D structure prediction of TMBs.
  28. Solomon K, Stephenson G. Quantitative weight of evidence assessment of risk to honeybee colonies from use of imidacloprid, clothianidin, and thiamethoxam as seed treatments: a postscript. J Toxicol Environ Health B Crit Rev. 2017;:1-4 pubmed publisher
    ..the application of the QWoE process to studies on imidacloprid (IMI), clothianidin (CTD), and thiamethoxam (TMX)...
  29. Velmurugan B, Wang P, Weng C. 16-Hydroxycleroda-3,13-dien-15,16-olide and N-Methyl-Actinodaphine Potentiate Tamoxifen-Induced Cell Death in Breast Cancer. Molecules. 2018;23: pubmed publisher
    ..HCD) and N-methyl-actinodaphine (MA) could sensitize breast cancer cells to Tamoxifen (TMX) treatment...
  30. Tavares D, Roat T, Silva Zacarin E, Nocelli R, Malaspina O. Exposure to thiamethoxam during the larval phase affects synapsin levels in the brain of the honey bee. Ecotoxicol Environ Saf. 2019;169:523-528 pubmed publisher
    Thiamethoxam (TMX) is a neurotoxic insecticide widely used for insect pest control. TMX and other neonicotinoids are reported to be potential causes of honey bee decline...
  31. Cho S, Kim S, Son M, Rou W, Kim S, Eun H, et al. Clinical Significance of the Thioredoxin System and Thioredoxin-Domain-Containing Protein Family in Hepatocellular Carcinoma. Dig Dis Sci. 2019;64:123-136 pubmed publisher
    ..In accordance with the survival analyses, strong associations were found that patients with TXN, TXNRD1, and TXNDC1/7/9 alterations were proven to have poor prognosis in overall survival...
  32. Cantley J, Davenport A, Vetterli L, Nemes N, Whitworth P, Boslem E, et al. Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass. Diabetologia. 2019;62:99-111 pubmed publisher
    ..Acaca floxed mice were crossed with Ins2cre mice (βACC1KO; life-long beta cell gene deletion) or Pdx1creER mice (tmx-βACC1KO; inducible gene deletion in adult beta cells)...
  33. Pelkmans L, Hendriksz T, Westenend P, Vermeer H, van Bommel E. Elevated serum IgG4 levels in diagnosis and treatment response in patients with idiopathic retroperitoneal fibrosis. Clin Rheumatol. 2017;36:903-912 pubmed publisher
    ..It is unknown if tamoxifen (TMX) affects sIgG4 levels...
  34. Hong N, Yoon H, Seo D, Park S, Kim S, Sohn J, et al. Different patterns in the risk of newly developed fatty liver and lipid changes with tamoxifen versus aromatase inhibitors in postmenopausal women with early breast cancer: A propensity score-matched cohort study. Eur J Cancer. 2017;82:103-114 pubmed publisher
    ..We aimed to compare the effects of tamoxifen (TMX) and aromatase inhibitors (AIs) on the risk of fatty liver in conjunction with longitudinal changes in the serum ..
  35. Nichols M, Pavlov E, Robertson G. Tamoxifen-induced knockdown of the mitochondrial calcium uniporter in Thy1-expressing neurons protects mice from hypoxic/ischemic brain injury. Cell Death Dis. 2018;9:606 pubmed publisher
    ..also involved in hypoxic/ischemic (HI) brain injury, we have generated conditional MCU knockout mice by tamoxifen (TMX) administration to adult MCU-floxed (MCUfl/fl) mice expressing a construct encoding Thy1-cre/ERT2-eYFP...
  36. Arends T, Lammers R, Falke J, van der Heijden A, Rustighini I, Pozzi R, et al. Pharmacokinetic, Pharmacodynamic, and Activity Evaluation of TMX-101 in a Multicenter Phase 1 Study in Patients With Papillary Non-Muscle-Invasive Bladder Cancer. Clin Genitourin Cancer. 2015;13:204-9.e2 pubmed publisher
    Non-muscle-invasive bladder cancer (NMIBC) has a strong tendency to recur despite adjuvant instillations. TMX-101 is a new liquid form of imiquimod for intravesical instillation and has activity in vitro against urothelial carcinoma...
  37. Pandey S, Ghosh S, Maiti P, Haldar C. Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer. Int J Biol Macromol. 2015;72:309-19 pubmed publisher
    This study was carried out to assess the therapeutic efficacy and toxicity of tamoxifen (Tmx) loaded poly(d,l-lactic acid) (PLA) nanoparticles (Tmx-NPs) for breast cancer...
  38. Smith T, Baker M, Connaughton H, Habenicht U, Aitken R. Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Free Radic Biol Med. 2013;65:872-881 pubmed publisher
    ..The combined inactivation of these Txndc isoforms did not have an overall impact on spermatogenesis, epididymal sperm maturation, or fertility...
  39. Shuda M, Guastafierro A, Geng X, Shuda Y, Ostrowski S, Lukianov S, et al. Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. PLoS ONE. 2015;10:e0142329 pubmed publisher
    ..Standard tamoxifen (TMX) administration to adult UbcCreERT2; ROSAsT mice, in which Cre is ubiquitously expressed, resulted in MCV sT ..
  40. Mörtl M, Darvas B, Vehovszky A, Gyori J, Székács A. Contamination of the guttation liquid of two common weeds with neonicotinoids from coated maize seeds planted in close proximity. Sci Total Environ. 2019;649:1137-1143 pubmed publisher
    ..Uptake of thiamethoxam (TMX) and clothianidin (CLO) have been characterized via guttation liquid measurements...
  41. Wang L, Dong H, Song G, Zhang R, Pan J, Han J. TXNDC5 synergizes with HSC70 to exacerbate the inflammatory phenotype of synovial fibroblasts in rheumatoid arthritis through NF-?B signaling. Cell Mol Immunol. 2018;15:685-696 pubmed publisher
    ..Taken together, by linking HSC70 and NF-?B signaling, TXNDC5 plays a pro-inflammatory role in RASFs, highlighting a potential approach to treat RA by blocking the TXNDC5/HSC70 interaction. ..
  42. Imberti R, Garavaglia M, Verduci I, Cannavale G, Balduzzi G, Papetti S, et al. Antiestrogen- and tamoxifen-induced effects on calcium-activated chloride currents in epithelial cells carrying the ∆F508-CFTR point mutation. Respir Res. 2018;19:198 pubmed publisher
    ..The aim of this study was to investigate the effects of 17β-estradiol and tamoxifen citrate (TMX) on calcium-activated chloride channel (CaCC) currents in human bronchial epithelial cells carrying the ΔPhe508-..
  43. García Hernández M, Rodenas M, Cabas I, García Alcázar A, Chaves Pozo E, García Ayala A. Tamoxifen disrupts the reproductive process in gilthead seabream males and modulates the effects promoted by 17α-ethynylestradiol. Comp Biochem Physiol C Toxicol Pharmacol. 2016;179:94-106 pubmed publisher
    ..were fed a diet containing tamoxifen (Tmx), an estrogen receptor ligand used in cancer therapy, alone or combined with EE2, for 25 days and then fed a ..
  44. Falke J, Hulsbergen van de Kaa C, Maj R, Oosterwijk E, Witjes J. A placebo-controlled efficacy study of the intravesical immunomodulators TMX-101 and TMX-202 in an orthotopic bladder cancer rat model. World J Urol. 2018;36:1719-1725 pubmed publisher
    b>TMX-101 and TMX-202 are formulations of toll-like receptor 7 (TLR-7) agonists, under investigation for the treatment of urothelial carcinoma...
  45. Mazumdar S, Italiya K, Sharma S, Chitkara D, Mittal A. Effective cellular internalization, cell cycle arrest and improved pharmacokinetics of Tamoxifen by cholesterol based lipopolymeric nanoparticles. Int J Pharm. 2018;543:96-106 pubmed publisher
    ..nanoparticles for improved entrapment, better cell penetration and improved pharmacokinetics of Tamoxifen (TMX)...
  46. Balça Silva J, Matias D, do Carmo A, Girão H, Moura Neto V, Sarmento Ribeiro A, et al. Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines. Biochim Biophys Acta. 2015;1850:722-32 pubmed publisher
    ..Here we describe the potential synergistic behavior of the therapeutic combination of tamoxifen (TMX), a known inhibitor of PKC, and TMZ in GBM...
  47. Kessler S, Tiedeken E, Simcock K, Derveau S, Mitchell J, Softley S, et al. Bees prefer foods containing neonicotinoid pesticides. Nature. 2015;521:74-76 pubmed publisher
    ..nectar-relevant concentrations of three of the most commonly used neonicotinoids, imidacloprid (IMD), thiamethoxam (TMX), and clothianidin (CLO), in food...
  48. Lim Y, Lin C, Lin Y, Ma W, Hung D, Kao C. Tamoxifen Treatment and the Reduced Risk of Hyperlipidemia in Asian Patients With Breast Cancer: A Population-Based Cohort Study. Clin Breast Cancer. 2015;15:294-300 pubmed publisher
    The association between tamoxifen (TMX) treatment and the risk of developing hyperlipidemia remains unclear...
  49. Pandey S, Patel D, Maurya A, Thakur R, Mishra D, Vinayak M, et al. Controlled release of drug and better bioavailability using poly(lactic acid-co-glycolic acid) nanoparticles. Int J Biol Macromol. 2016;89:99-110 pubmed publisher
    Tamoxifen (Tmx) embedded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGA-Tmx) is prepared to evaluate its better DNA cleavage potential, cytotoxicity using Dalton's lymphoma ascite (DLA) cells and MDA-MB231 breast cancer cells...
  50. Paladino N, Guerin C, Lowery A, Attard A, Essamet W, Slotema E, et al. Characterization of adrenocortical tumors by 18F-FDG PET/CT: Does steroid hormone hypersecretion status modify the uptake pattern?. Surg Oncol. 2018;27:231-235 pubmed publisher
    adrenal tumor-to-liver uptake value (Tmx:Lmx) on 18F-FDG PET/CT is an accurate and reproducible PET parameter in the distinction between benign and malignant adrenal masses...
  51. Johansen P, Zucker D, Parhamifar L, Pourhassan H, Madsen D, Henriksen J, et al. Monocyte targeting and activation by cationic liposomes formulated with a TLR7 agonist. Expert Opin Drug Deliv. 2015;12:1045-58 pubmed publisher
    ..Liposomes with and without the TLR7 agonist TMX-202 were incubated with fresh blood, and monocyte activation measured by cytokine secretion by ELISA and CD14 and ..
  52. Wright G, Softley S, Earnshaw H. Low doses of neonicotinoid pesticides in food rewards impair short-term olfactory memory in foraging-age honeybees. Sci Rep. 2015;5:15322 pubmed publisher
    ..solutions containing field-relevant doses of the neonicotinoid pesticides, imidacloprid (IMD) and thiamethoxam (TMX), to sucrose alone...
  53. Sandhu P, Beg S, Katare O, Singh B. QbD-Driven Development and Validation of a HPLC Method for Estimation of Tamoxifen Citrate with Improved Performance. J Chromatogr Sci. 2016;54:1373-84 pubmed publisher
    ..sensitive and cost-effective high-performance liquid chromatographic method for estimation of tamoxifen citrate (TMx). The factor screening studies were performed using a 7-factor 8-run Taguchi design...
  54. Thulasitha W, Kim Y, Umasuthan N, Jayasooriya R, Kim G, Nam B, et al. Thioredoxin domain-containing protein 12 from Oplegnathus fasciatus: Molecular characterization, expression against immune stimuli, and biological activities related to oxidative stress. Fish Shellfish Immunol. 2016;54:11-21 pubmed publisher
    ..Taken together, the results from our study suggest that OfTXNDC12 encodes for a potent antioxidant involved in redox regulation that shows significant responses to immune stimuli. ..
  55. Aguirre Martínez G, Okello C, Salamanca M, Garrido C, Del Valls T, Martín Díaz M. Is the step-wise tiered approach for ERA of pharmaceuticals useful for the assessment of cancer therapeutic drugs present in marine environment?. Environ Res. 2016;144:43-59 pubmed publisher
    Methotrexate (MTX) and tamoxifen (TMX) cancer therapeutic drugs have been detected within the aquatic environment...
  56. Kim H, Amirsadeghi S, McKenzie Gopsill A, Afifi M, Bozzo G, Lee E, et al. Changes in light quality alter physiological responses of soybean to thiamethoxam. Planta. 2016;244:639-50 pubmed publisher
    ..of this enhanced growth and yield is not clear, recent studies suggest that neonicotinoids such as thiamethoxam (TMX) may exert their effects at least in part via signals that involve salicylic acid (SA) and jasmonic acid (JA)...
  57. Hofman J, Skarka A, Havrankova J, Wsol V. Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases. Biochem Pharmacol. 2015;96:168-78 pubmed publisher
    Paclitaxel (PTX), docetaxel (DTX), 5-fluorouracil (5-FU), cyclophosphamide (CYC) or tamoxifen (TMX) are combined with doxorubicin (DOX) in first-line chemotherapy regimens that are indicated for breast cancer patients...
  58. Altmeyer C, Karam T, Khalil N, Mainardes R. Tamoxifen-loaded poly(L-lactide) nanoparticles: Development, characterization and in vitro evaluation of cytotoxicity. Mater Sci Eng C Mater Biol Appl. 2016;60:135-142 pubmed publisher
    In this study, poly(L-lactide) (PLA) nanoparticles containing Tamoxifen (Tmx) were developed using an emulsion/solvent evaporation method, observing the influence of surfactants and their concentrations on mean particle size and drug ..
  59. Winquist A, Grundstein A, Chang H, Hess J, Sarnat S. Warm season temperatures and emergency department visits in Atlanta, Georgia. Environ Res. 2016;147:314-23 pubmed publisher
    ..and intestinal infections by age group (0-4, 5-18, 19-64, 65+years) in relation to daily maximum temperature (TMX) using Poisson time series models that included cubic terms for TMX at single-day lags of 0-6 days, controlling for ..
  60. Yazğan B, Yazğan Y, Ovey I, Naziroglu M. Raloxifene and Tamoxifen Reduce PARP Activity, Cytokine and Oxidative Stress Levels in the Brain and Blood of Ovariectomized Rats. J Mol Neurosci. 2016;60:214-22 pubmed publisher
    ..Raloxifene (RLX) and tamoxifen (TMX) are selective estrogen receptor modulators...
  61. Jena S, Sangamwar A. Polymeric micelles of amphiphilic graft copolymer of α-tocopherol succinate-g-carboxymethyl chitosan for tamoxifen delivery: Synthesis, characterization and in vivo pharmacokinetic study. Carbohydr Polym. 2016;151:1162-1174 pubmed publisher
    ..Cmc-TS4.5 (Cmc-TS with a charged molar ratio of TS to glucosamine units of Cmc∼4.5) was shown maximum TMX loading up to 8.08±0.98%. Both blank and TMX-loaded PM's of Cmc-TS4...
  62. Leśniak Walentyn A, Hrabia A. Expression and localization of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct during pause in laying induced by tamoxifen. Theriogenology. 2017;88:50-60 pubmed publisher
    ..hen oviduct (infundibulum, magnum, isthmus, shell gland, vagina) during a pause in egg laying induced by tamoxifen (TMX)-an estrogen receptor modulator...
  63. Klauber T, Laursen J, Zucker D, Brix S, Jensen S, Andresen T. Delivery of TLR7 agonist to monocytes and dendritic cells by DCIR targeted liposomes induces robust production of anti-cancer cytokines. Acta Biomater. 2017;53:367-377 pubmed publisher
    ..We formulated the immune stimulating TLR7 agonist TMX-202 in the liposomes and examined the targeting of the liposomes as well as their immune activating potential in ..
  64. Donin N, Chamie K, Lenis A, Pantuck A, Reddy M, Kivlin D, et al. A phase 2 study of TMX-101, intravesical imiquimod, for the treatment of carcinoma in situ bladder cancer. Urol Oncol. 2017;35:39.e1-39.e7 pubmed publisher
    Imiquimod is a toll-like receptor agonist with proven antitumor activity as a topical treatment for skin cancer. TMX-101 (Vesimune) is a novel liquid formulation of imiquimod optimized for intravesical delivery...
  65. Lim S, Nyam Tt E, Hu C, Chio C, Wang C, Kuo J. Estrogen Receptor-? is Involved in Tamoxifen Neuroprotective Effects in a Traumatic Brain Injury Male Rat Model. World Neurosurg. 2018;112:e278-e287 pubmed publisher
    To determine the neuroprotective mechanisms of tamoxifen (TMX) during traumatic brain injury (TBI), especially the effects on estrogen receptor-? (ER?) expression, as well as neuroinflammatory associations...
  66. Barratt H, Budnick H, Parra R, Lolley R, Perry C, Nesic O. Tamoxifen promotes differentiation of oligodendrocyte progenitors in vitro. Neuroscience. 2016;319:146-54 pubmed publisher
    ..Here we show that the breast cancer medication tamoxifen (TMX), with well-documented clinical safety and confirmed beneficial effects in various models of demyelinating ..
  67. Thulasitha W, Umasuthan N, Jayasooriya R, Noh J, Park H, Lee J. A thioredoxin domain-containing protein 12 from black rockfish Sebastes schlegelii: Responses to immune challenges and protection from apoptosis against oxidative stress. Comp Biochem Physiol C Toxicol Pharmacol. 2016;185-186:29-37 pubmed publisher
    ..Collectively, the present data indicate that RfTXNDC12 is a TXN superfamily member, which could function as a potential antioxidant enzyme and be involved in a defense mechanism against immune challenges. ..
  68. Jena S, Samal S, Kaur S, Chand M, Sangamwar A. Potential of amphiphilic graft copolymer ?-tocopherol succinate-g-carboxymethyl chitosan in modulating the permeability and anticancer efficacy of tamoxifen. Eur J Pharm Sci. 2017;101:149-159 pubmed publisher
    Recent studies showed an enhanced oral bioavailability of tamoxifen (TMX) by hydrophobically modified ?-tocopherol succinate-g-carboxymethyl chitosan (Cmc-TS) micelles...
  69. Rodenas M, Cabas I, Abellan E, Meseguer J, Mulero V, Garcia Ayala A. Tamoxifen persistently disrupts the humoral adaptive immune response of gilthead seabream (Sparus aurata L.). Dev Comp Immunol. 2015;53:283-92 pubmed publisher
    ..a marine hermaphrodite teleost. Tamoxifen (Tmx) is a selective estrogen-receptor modulator used in hormone replacement therapy, the effects of which are unknown ..
  70. Pandey D, Banerjee S, Basu M, Mishra N. Memory enhancement by Tamoxifen on amyloidosis mouse model. Horm Behav. 2016;79:70-3 pubmed publisher
    Tamoxifen (TMX) is a selective estrogen receptor modulator (SERM) used in the treatment of breast cancer. Earlier studies show its neuroprotection via regulating apoptosis, microglial functions, and synaptic plasticity...
  71. Aguirre Martínez G, Reinardy H, Martín Díaz M, Henry T. Response of gene expression in zebrafish exposed to pharmaceutical mixtures: Implications for environmental risk. Ecotoxicol Environ Saf. 2017;142:471-479 pubmed publisher
    ..05 and 5µM), tamoxifen-Tmx (0.003 and 0.3µM), and after exposure to pharmaceutical mixtures (low mix: 0.05µM of Caf, Ibu, Cbz and 0...
  72. Franco M, Sutherland G, Lavado R. Xenobiotic metabolism in the fish hepatic cell lines Hepa-E1 and RTH-149, and the gill cell lines RTgill-W1 and G1B: Biomarkers of CYP450 activity and oxidative stress. Comp Biochem Physiol C Toxicol Pharmacol. 2018;206-207:32-40 pubmed publisher
    ..These cell lines were exposed to ?-naphthoflavone (BNF) and benzo[a]pyrene (BaP), the pharmaceutical tamoxifen (TMX), and the organic peroxide tert-butylhydroperoxide (tBHP)...
  73. Shih Y, Chen C, Zhang Y, Mellor R, Kanter E, Fang Y, et al. Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation. Circ Res. 2018;122:1052-1068 pubmed publisher
    ..Targeting TXNDC5, therefore, could be a powerful new therapeutic approach to mitigate excessive cardiac fibrosis, thereby improving cardiac function and outcomes in patients with heart failure. ..
  74. Yuan K, Yong S, Xu F, Zhou T, McDonald J, Chen Y. Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer. Oncotarget. 2015;6:25308-19 pubmed publisher
    ..We investigated the effects of calmodulin(CaM) antagonists, trifluoperazine(TFP) and tamoxifen(TMX), on TRA-8-induced apoptosis and tumorigenesis of TRA-8-resistant pancreatic cancer cells, and underlying ..
  75. Zhang Z, Wang A, Li H, Zhi H, Lu F. STAT3-dependent TXNDC17 expression mediates Taxol resistance through inducing autophagy in human colorectal cancer cells. Gene. 2016;584:75-82 pubmed publisher
    ..These results suggest the possibility that TXNDC17 could play an important role in Taxol resistance via enhancing autophagy in human colorectal cancer cells. TXNDC17 may become a potential target of colorectal cancer therapeutics. ..
  76. Rodenas M, Cabas I, García Alcázar A, Meseguer J, Mulero V, García Ayala A. Selective estrogen receptor modulators differentially alter the immune response of gilthead seabream juveniles. Fish Shellfish Immunol. 2016;52:189-97 pubmed publisher
    ..EE2), a synthetic estrogen used in oral contraceptives and hormone replacement therapy, tamoxifen (Tmx), a selective estrogen-receptor modulator used in hormone replacement therapy, and G1, a G protein-coupled estrogen ..
  77. Jiménez López J, Ortega Barrales P, Ruiz Medina A. Development of an semi-automatic and sensitive photochemically induced fluorescence sensor for the determination of thiamethoxam in vegetables. Talanta. 2016;149:149-155 pubmed publisher
    The determination of thiamethoxam (TMX), a widely known neonicotinoid pesticide, by a multicommutated optosensing device implemented with photochemically induced fluorescence (PIF) has been developed...
  78. Sandhu P, Kumar R, Beg S, Jain S, Kushwah V, Katare O, et al. Natural lipids enriched self-nano-emulsifying systems for effective co-delivery of tamoxifen and naringenin: Systematic approach for improved breast cancer therapeutics. Nanomedicine. 2017;13:1703-1713 pubmed publisher
    The nano-miceller drug delivery carriers of tamoxifen (TMX) having natural ingredients like polyunsaturated fatty acid (PUFA) with self-nano-emulsifying properties was developed with naringenin (NG) in a synergistic manner i.e...
  79. Tian B, Yang J, Zhao Y, Ivanciuc T, Sun H, Wakamiya M, et al. Central Role of the NF-κB Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-Induced Airway Inflammation. J Virol. 2018;92: pubmed publisher
    ..Mice expressing a tamoxifen (TMX)-inducible Cre recombinase-estrogen receptor fusion protein (CreERTM) knocked into the Scgb1a1 locus were ..
  80. Wang L, Song G, Zheng Y, Wang D, Dong H, Pan J, et al. miR-573 is a negative regulator in the pathogenesis of rheumatoid arthritis. Cell Mol Immunol. 2016;13:839-849 pubmed publisher
    ..Indeed, MAPK signaling was essential to ensure the function of miR-573. Taken together, our study points toward the protective roles of miR-573 in the pathological process of RA and suggests a potential target in the treatment of RA. ..
  81. Lei L, Spradling A. Single-Cell Lineage Analysis of Oogenesis in Mice. Methods Mol Biol. 2017;1463:125-138 pubmed
    ..As in traditional lineage analysis, the method employs a Tamoxifen (Tmx)-inducible CAGCreER mouse line, which is crossed to an R26R reporter line that can be activated by Cre-mediated DNA ..
  82. Kassem M, Megahed M, Abu Elyazid S, Abd Allah F, Abdelghany T, Al Abd A, et al. Enhancing the Therapeutic Efficacy of Tamoxifen Citrate Loaded Span-Based Nano-Vesicles on Human Breast Adenocarcinoma Cells. AAPS PharmSciTech. 2018;19:1529-1543 pubmed publisher
    ..adverse effects and low selectivity to cancer cells are the main obstacles of long term therapy with Tamoxifen (Tmx)...
  83. Raturi A, Gutiérrez T, Ortiz Sandoval C, Ruangkittisakul A, Herrera Cruz M, Rockley J, et al. TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. J Cell Biol. 2016;214:433-44 pubmed publisher
    ..As a thiol-based tumor suppressor, TMX1 increases mitochondrial ATP production and apoptosis progression. ..
  84. Zhu Z, Li Y, Yang X, Pan W, Pan H. The reversion of anti-cancer drug antagonism of tamoxifen and docetaxel by the hyaluronic acid-decorated polymeric nanoparticles. Pharmacol Res. 2017;126:84-96 pubmed publisher
    Docetaxel (DTX) and tamoxifen (TMX) are first-line drugs used to treat breast cancer. However when used in combination, they produce antagonism because of their differential metabolic pathways...
  85. de Morais C, Carvalho S, Carvalho Naves M, Araujo G, de Rezende A, Bonetti A, et al. Mutagenic, recombinogenic and carcinogenic potential of thiamethoxam insecticide and formulated product in somatic cells of Drosophila melanogaster. Chemosphere. 2017;187:163-172 pubmed publisher
    Thiamethoxam (TMX) belongs to a class of neuro-active insecticides referred as neonicotinoids, while actara® (AC) is one of the most popular TMX-based products in Brazil...
  86. Aguirre Martínez G, Andre C, Gagne F, Martín Díaz L. The effects of human drugs in Corbicula fluminea. Assessment of neurotoxicity, inflammation, gametogenic activity, and energy status. Ecotoxicol Environ Saf. 2018;148:652-663 pubmed publisher
    ..different concentrations of caffeine (CAF), ibuprofen (IBU), carbamazepine (CBZ), novobiocin (NOV) and tamoxifen (TMX) for 21 days under laboratory conditions. During the assay, water was spiked every two days with CAF (0; 0...
  87. Socha J, Hrabia A. Alterations in apoptotic markers and egg-specific protein gene expression in the chicken oviduct during pause in laying induced by tamoxifen. Theriogenology. 2018;105:126-134 pubmed publisher
    ..of selected egg-specific proteins in the chicken oviduct during pause in egg laying induced by tamoxifen (TMX) treatment. The experiment was carried out on Hy-Line Brown laying hens...
  88. Valvassori S, Borges C, Varela R, Bavaresco D, Bianchini G, Mariot E, et al. The different effects of lithium and tamoxifen on memory formation and the levels of neurotrophic factors in the brain of male and female rats. Brain Res Bull. 2017;134:228-235 pubmed publisher
    ..Recently, preclinical studies have demonstrated the potential of tamoxifen (TMX) in the treatment of acute episodes of BD...
  89. Stephenson G, Solomon K. Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoids in honeybees. 4. Thiamethoxam. J Toxicol Environ Health B Crit Rev. 2017;:1-18 pubmed publisher
    ..of evidence (QWoE) methodology was used to assess several higher-tier studies on the effects of thiamethoxam (TMX) on honeybees...
  90. Galligan J, Petersen D. The human protein disulfide isomerase gene family. Hum Genomics. 2012;6:6 pubmed publisher
    ..Understanding the mechanisms of protein-folding, specifically thiol-disulfide exchange, may lead to development of a novel class of therapeutics that would help alleviate a wide range of diseases by targeting the UPR. ..
  91. Radolinski J, Wu J, Xia K, Stewart R. Transport of a neonicotinoid pesticide, thiamethoxam, from artificial seed coatings. Sci Total Environ. 2018;618:561-568 pubmed publisher
    ..Transport and distribution of a neonicotinoid (thiamethoxam, TMX) were investigated by growing TMX-coated corn seeds in coarse-textured and fine-textured soil columns (20 and 60cm ..
  92. Pickford D, Finnegan M, Baxter L, Böhmer W, Hanson M, Stegger P, et al. Response of the mayfly (Cloeon dipterum) to chronic exposure to thiamethoxam in outdoor mesocosms. Environ Toxicol Chem. 2018;37:1040-1050 pubmed publisher
    ..Environ Toxicol Chem 2018;37:1040-1050. © 2017 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC. ..