Gene Symbol: THAP9
Description: THAP domain containing 9
Alias: hTh9, DNA transposase THAP9, THAP domain-containing protein 9
Species: human
Products:     THAP9

Top Publications

  1. Roussigne M, Kossida S, Lavigne A, Clouaire T, Ecochard V, Glories A, et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem Sci. 2003;28:66-9 pubmed
    ..Our results suggest that the THAP domain is a novel example of a DBD that is shared between cellular proteins and transposases from mobile genomic parasites. ..
  2. Hammer S, Strehl S, Hagemann S. Homologs of Drosophila P transposons were mobile in zebrafish but have been domesticated in a common ancestor of chicken and human. Mol Biol Evol. 2005;22:833-44 pubmed publisher
    ..Finally, the evolutionary history of P element-homologous vertebrate sequences is discussed in the context of the "molecular domestication" hypothesis versus the "source gene hypothesis."..
  3. Sabogal A, Lyubimov A, Corn J, Berger J, Rio D. THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. Nat Struct Mol Biol. 2010;17:117-23 pubmed publisher
    ..analysis of natural and in vitro-selected binding sites suggests that several THAPs (DmTHAP and human THAP1 and THAP9) recognize a bipartite TXXGGGX(A/T) consensus motif; homology suggests THAP proteins bind DNA through a bipartite ..
  4. Majumdar S, Singh A, Rio D. The human THAP9 gene encodes an active P-element DNA transposase. Science. 2013;339:446-8 pubmed publisher
    ..The human THAP9 gene is related to the Drosophila P-element transposase...