Gene Symbol: THAP7
Description: THAP domain containing 7
Alias: THAP domain-containing protein 7
Macfarlan T, Kutney S, Altman B, Montross R, Yu J, Chakravarti D. Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor. J Biol Chem. 2005;280:7346-58 pubmed
..Here we demonstrate that THAP7, an uncharacterized member of the recently identified THAP (Thanatos-associated protein) family of proteins, is ..
Macfarlan T, Parker J, Nagata K, Chakravarti D. Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription. Mol Endocrinol. 2006;20:335-47 pubmed
..two-hybrid screen and identified a previously uncharacterized human protein called thanatos-associated protein-7 (THAP7), a member of a large family of THAP domain-containing putative DNA-binding proteins...
Dejosez M, Krumenacker J, Zitur L, Passeri M, Chu L, Songyang Z, et al
. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell. 2008;133:1162-74 pubmed publisher
..Our findings identify Ronin as an essential factor underlying embryogenesis and ES cell pluripotency. Its association with HCF-1 suggests an epigenetic mechanism of gene repression in pluripotent cells. ..
Michel A, Choudhury K, Firth A, Ingolia N, Atkins J, Baranov P. Observation of dually decoded regions of the human genome using ribosome profiling data. Genome Res. 2012;22:2219-29 pubmed publisher
Luykx J, Olde Loohuis L, Neeleman M, Strengman E, Bakker S, Lentjes E, et al
. Peripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid. Transl Psychiatry. 2016;6:e983 pubmed publisher
..significantly associated with CSF serotonin metabolite levels after Bonferroni correction for multiple testing: THAP7 (P=2.8 × 10-8, ?=0.08) and DDX6 (P=2.9 × 10-7, ?=0.07)...
Roussigne M, Kossida S, Lavigne A, Clouaire T, Ecochard V, Glories A, et al
. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem Sci. 2003;28:66-9 pubmed
..Our results suggest that the THAP domain is a novel example of a DBD that is shared between cellular proteins and transposases from mobile genomic parasites. ..