Gene Symbol: THAP12
Description: THAP domain containing 12
Alias: DAP4, P52rIPK, PRKRIR, THAP0, 52 kDa repressor of the inhibitor of the protein kinase, 58 kDa interferon-induced protein kinase-interacting protein, P58IPK-regulatory protein, THAP domain-containing protein 0, THAP domain-containing protein 12, death-associated protein 4, inhibitor of protein kinase PKR, p58IPK-interacting protein, protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor), testicular tissue protein Li 133
Species: human
Products:     THAP12

Top Publications

  1. Hu N, Kadota M, Liu H, Abnet C, Su H, Wu H, et al. Genomic Landscape of Somatic Alterations in Esophageal Squamous Cell Carcinoma and Gastric Cancer. Cancer Res. 2016;76:1714-23 pubmed publisher
    ..MSH3, PTCH, NF1, ERBB2, and CHEK2, and potentially novel cancer-associated genes, KISS1R, AMH, MNX1, WNK2, and PRKRIR Finally, we identified recurrent chromosome alterations in at least 30% of tumors in genes, including MACROD2, ..
  2. Mellor H, Proud C. A synthetic peptide substrate for initiation factor-2 kinases. Biochem Biophys Res Commun. 1991;178:430-7 pubmed
    ..The phosphorylation of the peptide by dsI and the phosphorylation of eIF-2 alpha by dsI or HCR showed sigmoidal kinetics with respect to substrate concentration. ..
  3. Shi Y, Vattem K, Sood R, An J, Liang J, Stramm L, et al. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol. 1998;18:7499-509 pubmed
    ..We also identified PEK homologs from both Caenorhabditis elegans and the puffer fish Fugu rubripes, suggesting that this eIF-2alpha kinase plays an important role in translational control from nematodes to mammals. ..
  4. Lu J, O Hara E, Trieselmann B, Romano P, Dever T. The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha. J Biol Chem. 1999;274:32198-203 pubmed
    ..These results provide new insights into the substrate recognition properties of the eIF2alpha kinases, and they are intriguing considering the potential for alternate substrates for PKR in cellular signaling and growth control pathways. ..
  5. Saelens X, Kalai M, Vandenabeele P. Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. J Biol Chem. 2001;276:41620-8 pubmed
    ..Our results demonstrate a new and caspase-dependent activation mode for PKR, leading to eIF2-alpha phosphorylation and translation inhibition in apoptosis. ..
  6. Luig C, K├Âther K, Dudek S, Gaestel M, Hiscott J, Wixler V, et al. MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR. FASEB J. 2010;24:4068-77 pubmed publisher
    ..Accordingly, knockdown of MKs resulted in enhanced phosphorylation of PKR and its substrate eIF2?. ..
  7. Now H, Yoo J. A protein-kinase, IFN-inducible double-stranded RNA dependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated antiviral response through the stability control of RIG-I protein. Biochem Biophys Res Commun. 2011;413:487-93 pubmed publisher
    ..In the present study, we report PRKRIR, a negative regulator of PKR inhibitor, as a novel RIG-I interacting protein...
  8. Polyak S, Tang N, Wambach M, Barber G, Katze M. The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. J Biol Chem. 1996;271:1702-7 pubmed
    ..These data, taken together, demonstrate that P58 inhibits PKR through a direct interaction, which is likely independent of the binding of double-stranded RNA to the protein kinase. ..
  9. Gale M, Blakely C, Hopkins D, Melville M, Wambach M, Romano P, et al. Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. Mol Cell Biol. 1998;18:859-71 pubmed
    ..This protein, designated P52rIPK, possesses limited homology to the charged domain of Hsp90 and is expressed in a wide range of cell lines...

More Information


  1. Gale M, Blakely C, Darveau A, Romano P, Korth M, Katze M. P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress. Biochemistry. 2002;41:11878-87 pubmed
  2. Lin Y, Khokhlatchev A, Figeys D, Avruch J. Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem. 2002;277:47991-8001 pubmed COS-7 cells with an endogenous 761-amino acid polypeptide known as "death-associated protein 4" (DAP4)...
  3. Lee J, Choi S, Hwang T, Kim M, Jung G, Roh M, et al. A gene expression in study human gastric adenocarcinoma using a cDNA microarray. Korean J Gastroenterol. 2003;42:484-95 pubmed
  4. Clouaire T, Roussigne M, Ecochard V, Mathe C, Amalric F, Girard J. The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity. Proc Natl Acad Sci U S A. 2005;102:6907-12 pubmed
    ..100 distinct THAP proteins in model animal organisms, including human nuclear proapoptotic factors THAP1 and DAP4/THAP0, transcriptional repressor THAP7, zebrafish orthologue of cell cycle regulator E2F6, and Caenorhabditis elegans ..