Gene Symbol: THAP11
Description: THAP domain containing 11
Alias: CTG-B43a, CTG-B45d, HRIHFB2206, RONIN, THAP domain-containing protein 11
Species: human
Products:     THAP11

Top Publications

  1. Dejosez M, Krumenacker J, Zitur L, Passeri M, Chu L, Songyang Z, et al. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell. 2008;133:1162-74 pubmed publisher
    ..Here we describe a candidate pluripotency factor, Ronin, that possesses a THAP domain, which is associated with sequence-specific DNA binding and epigenetic silencing of ..
  2. Zhu C, Li C, Li Y, Zhan Y, Li Y, Xu C, et al. Cell growth suppression by thanatos-associated protein 11(THAP11) is mediated by transcriptional downregulation of c-Myc. Cell Death Differ. 2009;16:395-405 pubmed publisher
    ..b>THAP11 is the most recently described member of this human protein family...
  3. Michaud J, Praz V, James Faresse N, Jnbaptiste C, Tyagi S, Schutz F, et al. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy. Genome Res. 2013;23:907-16 pubmed publisher
    ..underlying the HCFC1-binding sites revealed three sequence motifs associated with the binding of (1) ZNF143 and THAP11 (also known as Ronin), (2) GABP, and (3) YY1 sequence-specific transcription factors...
  4. Roussigne M, Kossida S, Lavigne A, Clouaire T, Ecochard V, Glories A, et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem Sci. 2003;28:66-9 pubmed
    ..Our results suggest that the THAP domain is a novel example of a DBD that is shared between cellular proteins and transposases from mobile genomic parasites. ..
  5. Nakamura S, Yokota D, Tan L, Nagata Y, Takemura T, Hirano I, et al. Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression. Int J Cancer. 2012;130:1046-59 pubmed publisher
    ..In our study, we investigated the role of Thanatos-associated protein 11 (THAP11), which inhibits c-Myc transcription, in CML cell lines and in hematopoietic progenitor cells derived from CML ..
  6. Parker J, Palchaudhuri S, Yin H, Wei J, Chakravarti D. A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell function. Mol Cell Biol. 2012;32:1654-70 pubmed publisher
    ..In this work, we identify THAP11 as a transcriptional regulator differentially expressed in human colon cancer...
  7. Sanghavi H, Mallajosyula S, Majumdar S. Classification of the human THAP protein family identifies an evolutionarily conserved coiled coil region. BMC Struct Biol. 2019;19:4 pubmed publisher
    ..A coiled coil region is known to help in protein oligomerization in THAP1 and THAP11. It is not known if other human THAP proteins oligomerize...
  8. Ottenhausen M, Anetsberger S, Kleffmann J, Schuss P, Konczalla J, Krawagna M, et al. Risk Factors for Dropping Out of Neurosurgical Residency Programs-A Survey Study. World Neurosurg. 2018;120:e100-e106 pubmed publisher
  9. Potting C, Crochemore C, Moretti F, Nigsch F, Schmidt I, Manneville C, et al. Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy. Proc Natl Acad Sci U S A. 2018;115:E180-E189 pubmed publisher
    ..A transcriptional repressor network including THAP11 was identified and negatively regulates endogenous PARKIN abundance...

More Information


  1. Seifert B, Dejosez M, Zwaka T. Ronin influences the DNA damage response in pluripotent stem cells. Stem Cell Res. 2017;23:98-104 pubmed publisher
    ..Ronin (Thap11) is a transcriptional regulator responsible for vital programs in pluripotent cells...
  2. Scalais E, Osterheld E, Weitzel C, De Meirleir L, Mataigne F, Martens G, et al. X-Linked Cobalamin Disorder (HCFC1) Mimicking Nonketotic Hyperglycinemia With Increased Both Cerebrospinal Fluid Glycine and Methylmalonic Acid. Pediatr Neurol. 2017;71:65-69 pubmed publisher
    ..Putative binding sites for HCFC1 and its binding partner THAP11 were identified near genes of the glycine cleavage enzyme, providing a potential mechanistic link between HCFC1 ..
  3. Vinckevicius A, Parker J, Chakravarti D. Genomic Determinants of THAP11/ZNF143/HCFC1 Complex Recruitment to Chromatin. Mol Cell Biol. 2015;35:4135-46 pubmed publisher
    The THAP11 and ZNF143 transcription factors recognize overlapping DNA sequences and are reported to exhibit signs of both competitive and cooperative binding...
  4. Poché R, Zhang M, Rueda E, Tong X, McElwee M, Wong L, et al. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Cell Rep. 2016;14:1684-1697 pubmed publisher
    ..Here, we identify RONIN (THAP11) as a key transcriptional regulator of retinal progenitor cell (RPC) proliferation...
  5. Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M. Selection system for genes encoding nuclear-targeted proteins. Nat Biotechnol. 1998;16:1338-42 pubmed
    ..We propose that NTT is an efficient method for isolating cDNAs that encode nuclear targeted proteins that can be applied to the retrieval of novel nuclear proteins and to annotate gene function. ..
  6. Fujita J, Freire P, Coarfa C, Benham A, Gunaratne P, Schneider M, et al. Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs. Cell Rep. 2017;21:1562-1573 pubmed publisher
    Ronin (THAP11), a DNA-binding protein that evolved from a primordial DNA transposon by molecular domestication, recognizes a hyperconserved promoter sequence to control developmentally and metabolically essential genes in pluripotent stem ..
  7. Trung N, Kremmer E, Mittler G. Biochemical and cellular characterization of transcription factors binding to the hyperconserved core promoter-associated M4 motif. BMC Genomics. 2016;17:693 pubmed publisher
    ..Recent genome-wide studies have described M4 as a transcription factor (TF) binding site for THAP11 that does often overlap with SBS (STAF Binding Site) a second core-promoter associated TF binding module, which ..
  8. Zheng W, Dong X, Yin R, Xu F, Ning H, Zhang M, et al. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cells. 2014;32:2278-89 pubmed publisher
    ..Microarray analysis suggested that EDAG knockdown selectively inhibits GATA1-activated target genes. These data provide novel insights into EDAG in regulation of erythroid differentiation. ..
  9. Durruthy Durruthy J, Wossidlo M, Pai S, Takahashi Y, Kang G, Omberg L, et al. Spatiotemporal Reconstruction of the Human Blastocyst by Single-Cell Gene-Expression Analysis Informs Induction of Naive Pluripotency. Dev Cell. 2016;38:100-15 pubmed publisher silico precursors of the epiblast and primitive endoderm lineages and revealed a role for MCRS1, TET1, and THAP11 in epiblast formation and their ability to induce naive pluripotency in vitro...
  10. Cukier C, Maveyraud L, Saurel O, Guillet V, Milon A, Gervais V. The C-terminal region of the transcriptional regulator THAP11 forms a parallel coiled-coil domain involved in protein dimerization. J Struct Biol. 2016;194:337-46 pubmed publisher
    Thanatos associated protein 11 (THAP11) is a cell cycle and cell growth regulator differentially expressed in cancer cells...
  11. Parker J, Yin H, Vinckevicius A, Chakravarti D. Host cell factor-1 recruitment to E2F-bound and cell-cycle-control genes is mediated by THAP11 and ZNF143. Cell Rep. 2014;9:967-82 pubmed publisher numerous E2F-bound promoters is mediated by the concerted action of zinc finger transcription factors THAP11 and ZNF143, rather than E2F proteins directly...
  12. Kong X, Yin R, Ning H, Zheng W, Dong X, Yang Y, et al. Effects of THAP11 on erythroid differentiation and megakaryocytic differentiation of K562 cells. PLoS ONE. 2014;9:e91557 pubmed publisher
    ..b>THAP11 is a transcription factor involved in cell growth, ES cell pluripotency, and embryogenesis...
  13. Lian W, Yin R, Kong X, Zhang T, Huang X, Zheng W, et al. THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line. FEBS Lett. 2012;586:1431-8 pubmed publisher
    b>THAP11 is an essential factor involved in ES cell pluripotency and cell growth. Here, we identified THAP11 as a novel physiological binding partner of PCBP1...
  14. Li S, McInnis M, Margolis R, Antonarakis S, Ross C. Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. Genomics. 1993;16:572-9 pubmed
  15. Quintana A, Yu H, Brebner A, Pupavac M, Geiger E, Watson A, et al. Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities. Hum Mol Genet. 2017;26:2838-2849 pubmed publisher
    ..HCFC1 regulates cobalamin metabolism via the regulation of MMACHC expression through its interaction with THAP11, a THAP domain-containing transcription factor...
  16. Gervais V, Campagne S, Durand J, Muller I, Milon A. NMR studies of a new family of DNA binding proteins: the THAP proteins. J Biomol NMR. 2013;56:3-15 pubmed publisher
    ..It provides the solution structure of the THAP domain of THAP11, a recently characterized human THAP protein with important functions in transcription and cell growth in colon ..